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bacterial infections in infants 60 days and younger: epidemiology, resistance, and implications for treatment.to establish what might be more optimal initial antibiotic therapy for suspected invasive bacterial infections in infants 60 days or younger who are evaluated in the emergency department (ed).199910357302
[evaluation of the phoenix system for identifying and determining the susceptibility of clinical isolates. comparative study with the microscan system].the phoenix system (bd diagnostic systems), a rapid id/ast system, was compared with the microscan walkaway-40 system for accuracy of identification and antimicrobial susceptibility test results. the 327 bacterial isolates, were comprised of 191 gram-negative bacilli (187 enterobacteriaceae and 4 aeromonas spp.) and 136 gram-positive cocci (27 staphylococcus aureus, 53 coagulase-negative staphylococci, 45 enterococci and 11 beta haemolytic streptococci). the overall rate of agreement between the ...200415470511
the culture site of the gallbladder affects recovery of bacteria in symptomatic cholelithiasis.traditional methods for bile culturing may miss a large number of underlying bacterial infections that could lead to acute or chronic cholecystitis.200818568139
relative rates of lysis of staphylococcal cell walls by lytic enzymes from various bacteriophage types.lytic enzymes were isolated from 14 strains of phage-infected staphylococcus aureus. cell walls were prepared from the same uninfected strains of bacteria. comparison of the lytic rates was made for each enzyme, with each of the cell walls as substrate. differences in the rate of substrate utilization of the various cell wall types exceeded 10-fold. cell walls from strains 42e, 29, and 77 were the best substrates, whereas cell walls from strains 3c, 80, and 187 were the poorest substrates. the c ...19694239703
[effect of peptidoglycan preparations on phage inactivation: decrease in phage 187 binding using monosaccharides].monosaccharides were found to be capable to decreasing the binding of phage 187 with peptidoglycan. galactosamine hydrochloride and glucosamine hydrochloride proved to be the most effective, followed in order of decreasing activity by n-acetylgalactosamine, n-acetylglucosamine, glucose and galactose; mannose produced a weak effect. ca2+ ions increased the reduction of phage peptiglycan binding with n-acetylgalactosamine and n-acetylglucosamine. both of these monosaccharides also reduced the adso ...1977143171
identification of spya, a novel adp-ribosyltransferase of streptococcus pyogenes.streptococcus pyogenes, the aetiological agent of both respiratory and skin infections, produces numerous exotoxins to establish infection. this report identifies a new exotoxin produced by this organism, termed spya, for s. pyogenesadp-ribosylating toxin. spya, mw 24.9, has amino acid identity with the adp-riboslytransferases (adprts) staphylococcus aureus edin and clostridium botulinum c3. recombinant spya was able to hydrolyse beta-nad(+), and this activity was dependent on a glutamate at pos ...200415458407
somatic cell counts and bacteriological status in quarter foremilk samples of cows in hesse, germany--a longitudinal study.somatic cell counts (scc) are generally used as an indicator of udder health. currently in germany, 100,000 cells/ml is the threshold differentiating infected and noninfected mammary glands. the aim of our study was the detailed analysis of udder health in a representative part of the dairy cow population in hesse, germany. between 2000 and 2008, 615,187 quarter foremilk samples were analyzed. in addition to evaluation of distribution of scc and prevalence of mastitis pathogens, pathogen prevale ...201021094743
[a routine prospective survey process to detect nosocomial bacterial colonization in a neonatal unit: risk factors for acquisition].a systematic analysis of weekly nasal and rectal swabs was carried out in a neonatal unit in order to detect colonization with multiresistant bacteria (mrb).200415519828
wound healing: captopril, an angiogenesis inhibitor, and staphylococcus aureus peptidoglycan.captopril, an angiotensin-converting enzyme inhibitor, used for treating hypertension and heart failure, inhibits angiogenesis in the corneas of rats in response to basic fibroblast growth factor, slows the growth of experimental tumors in rats, and leads to the regression of kaposi's sarcoma. because angiogenesis is key to wound healing, we hypothesized that captopril would impair wound healing. we hypothesized also that because local application at operation of staphylococcus aureus peptidogly ...200010896819
microbial profile of neonatal infection in coimbatore.in this study, 187 consecutive neonates suspected of having septicaemia were investigated for isolation of micro organisms. two samples of blood were collected for isolation of aerobes and anaerobes. cultures were positive in 75 (40%) cases. aerobic bacteria were the major etiological agent, accounting for 93% of positives including the 8% cases showing polymicrobial etiology. anaerobic bacteria and candida species were isolated in 6.6% and 8% of positive cases respectively. bacteroides fragilis ...199910798030
matrix-binding proteins of staphylococcus aureus: functional analysis of mutant and hybrid molecules.the fibrinogen-binding protein clfa and the collagen-binding protein cna are surface-associated adhesins of staphylococcus aureus. clfa has a dipeptide repeat region r composed mainly of serine and aspartate residues, more than 40 of which are required along with the 28-residue region w, the lpxtg motif and region m to display the ligand-binding region a on the cell surface in a functional form. cna has a 61-residue region w and at least one 187-residue region b linking the collagen-binding regi ...199910517602
evidence for a holin-like protein gene fully embedded out of frame in the endolysin gene of staphylococcus aureus bacteriophage 187.we have cloned, sequenced, and characterized the genes encoding the lytic system of the unique staphylococcus aureus phage 187. the endolysin gene ply187 encodes a large cell wall-lytic enzyme (71.6 kda). the catalytic site, responsible for the hydrolysis of staphylococcal peptidoglycan, was mapped to the n-terminal domain of the protein by the expression of defined ply187 domains. this enzymatically active n terminus showed convincing amino acid sequence homology to an n-acetylmuramoyl-l-alanin ...199910419939
epidemiosurveillance of antimicrobial compound resistance of staphylococcus intermedium clinical isolates from canine pyodermas.in a retrospective study, 131 staphylococcus intermedius strains isolated from apparently healthy dogs, and 187 staphylococcus intermedius strains isolated from dog pyodermas in the clinical microbiology laboratory at the national veterinary school in nantes, during three successive periods: 1986-87, 1992-93 and 1995-96, were investigated and compared for their antimicrobial susceptibility. results indicated that 60% to 65% of the strains were susceptible to chloramphenicol and doxycyclin, 65% t ...19989611682
in vitro evaluation of sparfloxacin activity and spectrum against 24,940 pathogens isolated in the united states and canada, the final analysis.sparfloxacin, a recently marketed oral fluoroquinolone, was tested against 24,940 recent clinical strains isolated from blood stream and respiratory tract cultures at 187 hospitals in the usa and canada. sparfloxacin activity was compared with 5 to 13 antimicrobial agents using either etest (ab biodisk, solna, sweden) and a reference broth microdilution or a standardized disk diffusion method. when applying recommended mic breakpoint criteria of sparfloxacin susceptibility (< or = 0.5 microgram/ ...19989597392
[bacteriologic evaluation of otitis externa and chronic otitis media].the authors present results of bacteriological examinations in 187 patients with chronic otitis media (omc) and otitis externa treated in ent department, medical university of gdaƄsk in the years 1997-1998. ear swabs and aspirates were investigated for aerobes and anaerobes 254 bacterial isolates were obtained. among 150 patients with omc aerobes were isolated in 130 (86.7%) in 13 (8.5%) mixed aero-anaerobes flore and in 20 (19.3%) no bacterial growth was observed. from patients with com there w ...200011202342
identifying exposure targets for treatment of staphylococcal pneumonia with ceftobiprole.ceftobiprole is a cephalosporin with potent activity against methicillin (meticillin)-resistant staphylococcus aureus (mrsa). in order to treat patients with severe staphylococcal pneumonia, it is important to understand the drug exposure required to mediate the killing of multiple log(10) cells in a preclinical-infection model. we measured drug exposure in terms of the percentage of penetration of the drug into epithelial lining fluid (elf) and in terms of the time for which the drug concentrat ...200919451287
[occurrence of methicillin-resistant strains in poland and their characteristics].the investigation was performed on 923 strains of s. aureus isolated from clinical material obtained from several regions of poland. resistance to methicillin was tested by a dilution method on a solid mueller-hinton medium supplemented with 2% of nacl. strains exhibiting mic higher than 4 micrograms/ml were determined as resistant. resistance to other antibiotics (p, am, cb, cf, ch, ma, ge, bs, e, l, dx) was tested by a disc method. bacteriophage typing of s. aureus was performed by a method de ...19938189796
inducible resistance to a 16-membered macrolide, mycinamicin, in staphylococcus aureus resistant to 14-membered macrolides and streptogramin b antibiotics.staphylococcus aureus 8325(pep2104), a transductant derived from s. aureus pm2104 isolated clinically in hungary (l. janosi, and e. ban, acta microbiol. acad. sci. hung., 29: 187-200, 1982), exhibited an inducible resistance to the 14-membered macrolides [erythromycin (em) and oleandomycin (ol)] and streptogramin b (mkm-b) antibiotics, but not to the 16-membered macrolides and lincosamides. this resistance was referred to as pms-resistance phenotype (l. jánosi, y. nakajima, and h. hashimoto, mic ...19921432570
an increase of 63 kda-protein present in the cell membranes of staphylococcus aureus that bears a plasmid mediating inducible resistance to partial macrolide and streptogramin b antibiotics.a plasmid, pep2104 (23.9 kilobase pairs), from staphylococcus aureus carries a gene that specifies inducible resistance to 14-membered (erythromycin, em, and oleandomycin, ol) and 16-membered macrolide (mycinamicin i and ii), but not to all of the latter, and to streptogramin type b antibiotics (partial macrolide- and streptogramin-b-antibiotic resistance: pms-resistance) (l. jánosi, e. bán, acta microbiol. acad. sci. hung., 29, 187 (1982) and y. nakajima et al., j. pharmacobio-dyn., 15, 319 (19 ...19938130780
[effectivity of murein preparations in the phage inhibition test--effect of ca++ions and edta].the inactivating efficacy for the typing phages 54, 83a, and 187 of the peptidoglycan of staphylococcus aureus is decreased by increasing the ca++-content of the medium; the irreversible inhibition of phage 187 becomes reversible. the percentage of its inhibition is proportional to the ca++-content of the medium. minute amounts of phage 187 bound irreversibly under ca++-deprivation can be loosened by addition of ca++-ions. addition of edta up to the equivalence concentration of ca++ present in t ...1978148168
vancomycin mic plus heteroresistance and outcome of methicillin-resistant staphylococcus aureus bacteremia: trends over 11 years.vancomycin mics (v-mic) and the frequency of heteroresistant vancomycin-intermediate staphylococcus aureus (hvisa) isolates are increasing among methicillin (meticillin)-resistant staphylococcus aureus (mrsa) isolates, but their relevance remains uncertain. we compared the v-mic (etest) and the frequency of hvisa (etest macromethod) for all mrsa blood isolates saved over an 11-year span and correlated the results with the clinical outcome. we tested 489 isolates: 61, 55, 187, and 186 isolates re ...200919369444
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