| analysis of human cancer dna for dna sequences of human adenovirus type 4. | we investigated whether human adenovirus type 4 (ad4) might cause cancer in humans. cell culture and animal model studies indicated that ad4-induced human tumors should contain ad4 dna sequences. thus ad4 dna was labeled in vitro (sp act, approximately 10(7) 3h counts/min/microgram) and hybridized in liquid phase with dna extracted from human tumors. no viral sequences were detected in 31 squamous cell carcinomas of the lung, 5 adenocarcinomas of the lung, 4 oat cell carcinomas of the lung, 4 ca ... | 1979 | 281575 |
| immunogenicity of recombinant adenovirus-respiratory syncytial virus vaccines with adenovirus types 4, 5, and 7 vectors in dogs and a chimpanzee. | recombinant adenovirus type 4, 5, and 7 expressing the fusion glycoprotein (f) gene, the attachment glycoprotein (g) gene, or both f and g genes of respiratory syncytial virus (rsv) was constructed. intratracheal immunization of dogs with ad7f induced moderate titers of rsv-neutralizing antibodies. after booster immunization with ad4f, the dogs developed high titers of rsv-specific antibody. subsequently, three two-dose vaccination regimens, ad4f/ad5f, ad7g/ad4g, and ad7fg/ad4fg, were compared w ... | 1992 | 1527411 |
| replication of adenovirus type 4 dna by a purified fraction from infected cells. | an extract from adenovirus type 4 infected hela cells was fractionated by ion-exchange and dna affinity chromatography. one fraction, which bound tightly to single stranded dna, contained predominantly a protein of apparent molecular weight 65,000 and three less abundant proteins. immunological cross-reactivity with adenovirus type 2 proteins confirmed the presence of preterminal protein and indicated that the abundant species was the virus coded dna binding protein. this fraction contained an a ... | 1991 | 1829516 |
| outbreak of adenovirus type 4 conjunctivitis in south australia. | an outbreak of adenovirus type 4 conjunctivitis occurred in south australia between april and november 1992. eye swabs were submitted by general practitioners and ophthalmologists who had seen patients with clinical conjunctivitis or keratitis. apart from interfamilial spread, there were no other common epidemiological factors. adenovirus was isolated from the eye swabs of 38 patients. isolates were typed by neutralisation tests and restriction endonuclease cleavage patterns and found to be aden ... | 1993 | 8106866 |
| genome analysis of adenovirus type 4 strains isolated from acute conjunctivitis in japan. | strains of adenovirus type 4 (ad4) isolated from patients with acute conjunctivitis were studied by dna restriction analysis. the strains were isolated between july and december 1990 in japan. all 63 isolates of ad4 were identified as the genome type ad4a. this study showed that the same ad4 genome type, ad4a, caused acute viral conjunctivitis, even in different areas of japan. | 1997 | 9363559 |
| [construction of adenovirus 4 vector with deletion of 78.9-86 mu fragment and express of beta-galactosidase gene]. | to construct a human adenovirus type 4(ad4) vector with partial deletion at e3 region (78.9-86 mu). | 1999 | 12759945 |
| replication-attenuated human adenoviral type 4 vectors elicit capsid dependent enhanced innate immune responses that are partially dependent upon interactions with the complement system. | human adenovirus type 4 (hadv-4) is responsible for epidemic outbreaks of acute respiratory disease (especially in military recruits), and is known to cause significant morbidity with several reported cases of mortality. however, we do not understand why this serotype causes such high morbidity, and have little insight into the immunobiology of hadv-4 infections. we have now developed a replication attenuated hadv-4 vector system, and through it, demonstrate that hadv-4 virions have enhanced inf ... | 2008 | 18280530 |