| molecular epidemiological analysis of bat rabies viruses in brazil. | a molecular epidemiological analysis was performed in 19 rabies viruses (rvs) isolated from haematophagous, frugivorous and insectivorous bats, in sao paulo, brazil. the authors carried out rt-pcr for amplification of the rv nucleoprotein (n) gene, and determined 1,335 nucleotide sequences of n gene by direct sequencing method. phylogenetic analysis, which was based on the n gene of brazilian rv isolates identified presently and previously, revealed that rvs isolated from bats were genetically d ... | 2005 | 16082111 |
| pathogenicity of different rabies virus isolates and protection test in vaccinated mice. | this study was aimed to evaluate and compare the pathogenicity of rabies virus isolated from bats and dogs, and to verify the efficacy of a commercial rabies vaccine against these isolates. for evaluation of pathogenicity, mice were inoculated by the intramuscular route (im) with 500micld₅₀/0.03 ml of the viruses. the cross-protection test was performed by vaccinating groups of mice by the subcutaneous route and challenged through the intracerebral (ic) route. isolates were fully pathogenic when ... | 2010 | 21049225 |
| characterization of rabies virus isolated from a colony of eptesicus furinalis bats in brazil. | some bat species have adapted to the expanding human population by acquiring the ability to roost in urban buildings, increasing the exposure risk for people and domestic animals, and consequently, the likelihood of transmitting rabies. three dead bats were found in the yard of a house in an urban area of jundiaí city in the state of são paulo in southeast brazil. two of the three bats tested positive for rabies, using fluorescent antibody and mouse inoculation techniques. a large colony of epte ... | 2011 | 21412617 |
| monoclonal antibodies for characterization of rabies virus isolated from non-hematophagous bats in brazil. | in brazil, various isolates of rabies virus (rabv) show antigenic profiles distinct from those established by the reduced panel of eight monoclonal antibodies (mabs) determined by the centers for disease control and prevention (cdc), utilized for the antigenic characterization of rabv in the americas. the objective of this study was to produce mabs from rabv isolates from insectivorous bats with an antigenic profile incompatible with the pre-established one. | 2015 | 26623633 |
| host and viral traits predict zoonotic spillover from mammals. | the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ... | 2017 | 28636590 |