| the filamentous phages fd and if1 use different mechanisms to infect escherichia coli. | the filamentous phage fd uses its gene 3 protein (g3p) to target escherichia coli cells in a two-step process. first, the n2 domain of g3p attaches to an f pilus, and then the n1 domain binds to tola-c. n1 and n2 are tightly associated, rendering the phage robust but noninfectious because the binding site for tola-c is buried at the domain interface. binding of n2 to the f pilus initiates partial unfolding, domain disassembly, and prolyl cis-to-trans isomerization in the hinge between n1 and n2. ... | 2010 | 21110981 |