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the pathology of human cardiac transplantation: an assessment after 11 years' experience at groote schuur hospital.over a period of 11 years, commencing in december 1967, 31 cardiac transplants, 10 orthotopic and 21 heterotopic, were performed at groote schuur hospital. two patients with orthotopic transplants have a long survival, 1 for 7 1/2 and 1 for 9 1/2 years, and 1 with a heterotopic transplant for 4 years. eighteen patients have died, and autopsy was performed from 13 to 623 days postoperatively. rejection of the donor heart was found in 61,1% and was the cause of death in 44,4% of cases. infection, ...1979390737
characterization of the helicobacter pylori urease and purification of its subunits.helicobacter pylori (formerly campylobacter pylori) is the causative agent of gastritis in man. helicobacter pylori cells contain a large amount of an extremely active urease (e.c.3.5.1.5). this enzyme is suspected to be a virulence factor since the ammonium ion produced from urea may be responsible for tissue injury and/or survival of h. pylori in the gastric environment. helicobacter pylori urease, native relative molecular mass approximately 600,000, was purified by agarose gel filtration and ...19911857197
isolation and identification of 6-desmethylnaproxen sulfate as a new metabolite of naproxen in human plasma.a new metabolite of naproxen, 6-desmethylnaproxen sulfate (6-dmns), has been identified in plasma from normal and uremic subjects after oral administration of a single 500 mg dose of naproxen. tentative identification was achieved by the finding of an increase in the concentration of 6-dmn upon incubation of the plasma with arylsulfatase from helix pomatia or from aerobacter aerogenes. more definitive identification was established through demonstration that the hplc retention time of the conjug ...19892566468
bactericidal killing activities of cefepime, ceftazidime, cefotaxime, and ceftriaxone against staphylococcus aureus and beta-lactamase-producing strains of enterobacter aerogenes and klebsiella pneumoniae in an in vitro infection model.cefepime (cp) is a new injectable cephalosporin with a broad spectrum of activity and stability against common chromosomally and plasmid-mediated beta-lactamases. the bactericidal activities of cp, ceftazidime (cz), cefotaxime (ctx), and ceftriaxone (cax) against reference and clinical strains of staphylococcus aureus, an isogenic pair of enterobacter aerogenes strains (wild type and a cz-resistant derepressed mutant), and a klebsiella pneumoniae isolate possessing a tem-10 beta-lactamase were i ...19957486916
aerosolized antibiotics in mechanically ventilated patients: delivery and response.to determine whether aerosolized antibiotics can be delivered efficiently to the lower respiratory tract in mechanically ventilated patients and to define possible clinical responses to these agents.19989428540
the effects of plant phenolics, caffeic acid, chlorogenic acid and ferulic acid on arylamine n-acetyltransferase activities in human gastrointestinal microflora.the possible effects of naturally occurring plant phenolics, caffeic acid (ca), chlorogenic acid (cga) and ferulic acid (fa) on arylamine n-acetyltransferase (nat) activities on human gastrointestinal microflora, escherichia coli, klebsiella pneumoniae, enterobacter aerogenes, citrobacter koseri and pseudomonas aeruginosa, were examined. the bacterial nat activities were determined by hplc measuring the acetylation of 2-aminofluorene (2-af). among all examined bacteria, p. aeruginosa exerted the ...199910226534
the antimicrobial efficiency of piper betle linn leaf (stalk) against human pathogenic bacteria and phytopathogenic fungi.the in vitro antimicrobial activity of different varieties of piper betle linn, leaf stalk extracts were studied against human pathogenic bacteria and phytopathogenic fungi by comparing the results with standard microbial susceptibility testing biodiscs. the ethyl acetate and ethanol extracts of all the four varieties have shown significant activity against bacteria vibrio cholerae ogawa, staphylococcus aureus, diplococcus pneumoniae and klebsiella aerogenes. the hexane and benzene extracts have ...199910499145
antimicrobial and antioxidant activities of feijoa sellowiana fruit.the present study was designed to evaluate the antibacterial and antioxidant activities of an aqueous extract from the tropical feijoa sellowiana berg. fruit which is widely used for human food. the extract was tested against gram-positive and gram-negative bacteria by a broth dilution test and on human whole blood leukocytes, as well as isolated neutrophils using a chemiluminescence (cl) assay. the extract inhibited bacterial growth; pseudomonas aeruginosa, enterobacter aerogenes and enterobact ...200010724024
helicobacter pylori may survive ampicillin treatment in the remnant stomach.helicobacter pylori (h. pylori) is a gram-negative curved rod-like or spiral bacterium that chronically infects the human gastric mucosa, and is a major risk factor for gastritis, gastric and duodenal ulcer and adenocarcinoma of the stomach. after partial gastrectomy, some patients may have persistent h. pylori infection for five years or more. in this study, we detected three bacteria, i.e., klebsiella pneumoniae, enterobacter aerogenes, and escherichia coli, in the gastric juice of patients wi ...200212139018
[study on the antibacterial activity in vitro and on the absorption, diffusion and elimination in man of 6(d(-)-alpha-aminophenylacetamido)penicillanic acid]. 196314097440
presence of polysaccharide-forming coliforms in human saliva. 196514304302
metabolic activation of bladder procarcinogens, 2-aminofluorene, 4-aminobiphenyl, and benzidine by pseudomonas aeruginosa and other human endogenous bacteria.pseudomonas aeruginosa, an opportunistic pathogen of the human urinary tract, and other selected human endogenous bacteria were investigated for metabolic activation of the bladder procarcinogens, 2-aminofluorene (2-af), 4-aminobiphenyl (4-ab), and benzidine (bz). the cell-free extracts of pseudomonas aeruginosa, escherichia coli, enterobacter aerogenes, proteus mirabilis, proteus vulgaris, staphylococcus epidermidis, staphylococcus saprophyticus, klebsiella pneumoniae, and intestinal anaerobes, ...200616203120
differential activity of a lectin from solieria filiformis against human pathogenic bacteria.a lectin isolated from the red alga solieria filiformis was evaluated for its effect on the growth of 8 gram-negative and 3 gram-positive bacteria cultivated in liquid medium (three independent experiments/bacterium). the lectin (500 microg/ml) stimulated the growth of the gram-positive species bacillus cereus and inhibited the growth of the gram-negative species serratia marcescens, salmonella typhi, klebsiella pneumoniae, enterobacter aerogenes, proteus sp, and pseudomonas aeruginosa at 1000 m ...200516302091
antimicrobial disinfection effect of a laundering procedure for hospital textiles against various indicator bacteria and fungi using different substrates for simulating human excrements.recent studies confirm the increase of nosocomial infections and microbial resistance. one of the possible causes is infected textiles due to inappropriate laundering procedures. most slovenian laundries use thermal laundering procedures with high energy and water consumption to disinfect hospital textiles. in addition to this fact, there is an increasing number of hospital textiles composed of cotton/polyester blends that cannot endure high temperatures of thermal disinfection. on the other han ...200717046191
synthesis of pseudopeptides based l-tryptophan as a potential antimicrobial agent.four compounds named l-btrppa, l-trp-o-pa, l-trp-m-pa and l-trp-p-pa, pseudopeptides constructed from pyridine and tryptophan units, were synthesized and tested against the gram-positive, gram-negative strains of bacteria and human pathogenic fungi. l-trp-o-pa proved to be a broad-spectrum antimicrobial agent, showing a significant inhibition of the growth of gram-positive bacteria (staphylococcus aureus, methicillin-resistant s. aureus, bacillus subtilis, micrococcus luteus), and pathogenic fun ...200717257839
viper metalloproteinase (agkistrodon halys pallas) with antimicrobial activity against multi-drug resistant human pathogens.metalloproteinases are abundant enzymes in crotalidae and viperidae snake venoms. snake venom metalloproteinases (svmps) comprise a family of zinc-dependent enzymes, which display many different biological activities. a 23.1 kda protein was isolated from agkistrodon halys (pallas, chinese viper) snake venom. the toxin is a single chain polypeptide with a molecular weight of 23146.61 and an n-terminal sequence (miqvllvticlavfpyqgssiiles) relatively similar to that of other metalloprotein-like pro ...200818297685
efficacy of contact lens systems against recent clinical and tap water acanthamoeba isolates.a recent increase in acanthamoeba keratitis (ak) cases has been associated with complete moistureplus, although many cases used other solutions. complete moistureplus contains taurine and hydroxypropyl methylcellulose, unlike other multipurpose solutions (mpss). the purpose of this study is to (1) determine contact lens solution efficacy against recent clinical and tap water acanthamoeba isolates and (2) determine whether taurine inclusion increases acanthamoeba survival against contact lens sol ...200818580265
role of tolc in klebsiella oxytoca resistance to antibiotics.the gram-negative human pathogen klebsiella oxytoca is often resistant to several antibiotics such as fluoroquinolones, erythromycin, tetracycline, chloramphenicol and others. the aim of this study was to look at the mechanisms leading to this resistance and particularly the role of tolc and efflux mechanisms in determining resistance.200919240073
biogenic silver for disinfection of water contaminated with viruses.the presence of enteric viruses in drinking water is a potential health risk. growing interest has arisen in nanometals for water disinfection, in particular the use of silver-based nanotechnology. in this study, lactobacillus fermentum served as a reducing agent and bacterial carrier matrix for zerovalent silver nanoparticles, referred to as biogenic ag(0). the antiviral action of biogenic ag(0) was examined in water spiked with an enterobacter aerogenes-infecting bacteriophage (uz1). addition ...201020038697
antibacterial activity of artemisia nilagirica leaf extracts against clinical and phytopathogenic bacteria.the six organic solvent extracts of artemisia nilagirica were screened for the potential antimicrobial activity against phytopathogens and clinically important standard reference bacterial strains.201020109237
antimicrobial screening of ethnobotanically important stem bark of medicinal plants.the stem barks are the rich sources of tannins and other phenolic compounds. tannins inhibited the growth of various fungi, yeast, bacteria and virus. hence, ten stem barks of ethnomedicinally important plants were screened for antibacterial and antifungal activities against human pathogenic strains.201021808577
human placental 17 beta-hydroxysteroid dehydrogenase is homologous to nodg protein of rhizobium meliloti.the amino acid sequence of human placental 17 beta-hydroxysteroid dehydrogenase (17 beta-oh-steroid dehydrogenase) was found to be similar to that of the nodg protein of rhizobium meliloti. the computer-based comparison score is 11.5 sd higher than that obtained with 2500 comparisons of randomized sequences of these proteins. the probability of getting such a score by chance is 6 x 10(-31). 17 beta-oh-steroid dehydrogenase is also similar to klebsiella aerogenes ribitol dehydrogenase and escheri ...19892547159
pathological fracture of the right distal radius caused by enterobacter aerogenes osteomyelitis in an adult.a pathological fracture is a break in a diseased bone caused by weakening of the bone structure by a pathological process with no identifiable trauma. acute bacterial osteomyelitis that results in pathological fractures in the extremities is rare in adults. to our knowledge, we report the first case of enterobacter aerogenes osteomyelitis of the right distal radius, complicated with a pathological fracture, in a 79-year-old man with diabetes, which was diagnosed by radiological, microbiological, ...201020335785
stability and activity of an enterobacter aerogenes-specific bacteriophage under simulated gastro-intestinal conditions.a bacteriophage, designated uz1 and showing lytic activity against a clinically important strain (be1) of enterobacter aerogenes was isolated from hospital sewage. the stability and lytic activity against this strain under simulated gastro-intestinal conditions was evaluated. after addition of bacteriophage uz1 to a liquid feed at gastric ph 2, the phage was immediately inactivated and could not be recovered. however, by use of an antacid to neutralize stomach acidity, no significant changes in ...200414991251
antibiotic penetration in liver infection: a case of tobramycin failure responsive to moxalactam.a 23-year-old man sustained a severe liver laceration which subsequently became infected with enterobacter aerogenes. blood cultures were positive for this organism and the patient experienced sepsis. over the course of 18 days, his bilirubin and serum creatinine increased from normal to 40 and 2.7 mg/dl, respectively. tobramycin, clindamycin, and penicillin failed to control the infection despite in vitro sensitivity of the organism to tobramycin. moxalactam was started as a last resort, and th ...19836624739
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