community-acquired acinetobacter pneumonia in the northern territory of australia.eleven cases of blood culture-positive, community-acquired pneumonia due to the human commensal acinetobacter baumannii were studied in darwin in the northern territory of australia during the 10-year period from march 1981 through february 1991. demographic risk factors included male gender, age of greater than 45 years, and aboriginal ethnic background. multiple clinical risk factors, including cigarette smoking, alcoholism, chronic obstructive airway disease, and diabetes mellitus, were noted ...19921571467
nucleotide sequence of acinetobacter baumannii apha-6 gene: evolutionary and functional implications of sequence homologies with nucleotide-binding proteins, kinases and other aminoglycoside-modifying enzymes.a new kanamycin-resistance gene, detected in acinetobacter baumannii and designated apha-6, was sequenced. it specifies a 30319 dalton 3'-aminoglycoside phosphotransferase (aph(3'] that mediates resistance to kanamycin and structurally related aminoglycosides, including amikacin. pairwise comparisons of the six types of aph(3') so far detected in human pathogens (types i, ii, iii and vi) and in amino-glycoside-producing microorganisms (types iv and v), confirm that aph(3') enzymes have diverged ...19882846986
exposure of clinical isolates of acinetobacter baumannii and genospecies 3 to defibrinated human blood with and without added human 'natural' or (patient) immune antibodies.fresh defibrinated blood (65% v/v) from 2 human donors failed to completely kill strains of acinetobacter baumannii and genospecies 3, representing four serovars each. although colony counts were reduced > or = 90%, there invariably occurred rebound growth following extended incubation. neither selected serovar-specific or isolate-homologous (following experimental bacteremia) rabbit immune sera nor three intravenously applicable igg preparations augmented the bactericidal activity of human bloo ...19957758361
use of a new mouse model of acinetobacter baumannii pneumonia to evaluate the postantibiotic effect of imipenem.acinetobacter baumannii is responsible for severe nosocomial pneumonia. to evaluate new therapeutic regimens for infections due to multiresistant strains and to study the pharmacodynamic properties of various antibiotics, we developed an experimental mouse model of acute a. baumannii pneumonia. c3h/hen mice rendered transiently neutropenic were infected intratracheally with 5 x 10(6) cfu of a. baumannii. the mean log10 cfu/g of lung homogenate (+/- the standard deviation) were 9 +/- 0.9, 9.4 +/- ...19979021190
[sensitivity to blood bactericidal activity and hydrophobicity of acinetobacter baumannii after treatment with imipenem].sensitivity to the serum bactericidal activity and surface hydrophobicity of acinetobacter baumannii strains isolated from the urinary (ut) or respiratory tract (rt) of patients after exposure to imipenem at subinhibitory concentrations (sub-mics) (1/4, 1/8 or 1/16 of their mics) were tested. the antibiotic at the mentioned concentrations decreased significantly the sensitivity of strain ut to the bactericidal activity of human serum. sensitivity to the bactericidal activity of serum of strain r ...199910349782
distribution of acinetobacter species on skin of healthy humans.the distribution of the 19 currently known genospecies of acinetobacter on human skin, i.e. forehead, forearm and toe webs, was determined. three selective media were compared for their specificity for all genospecies of acinetobacter. a minimal-salts agar supplemented with 1% acetate proved to be more efficient than the leeds medium for the isolation of most genospecies in mixed culture with other bacterial species. acinetobacter isolates were provisionally identified using biochemical tests an ...199910357050
nontraditional dosing of ampicillin-sulbactam for multidrug-resistant acinetobacter baumannii meningitis.a 52-year-old man was admitted to a local hospital with headache, nausea, vomiting, dizziness, photophobia, and confusion after a sudden fall. progressive changes in neurologic function were noted despite neurosurgical intervention and broad-spectrum antimicrobial coverage. cerebral spinal fluid (csf) culture identified acinetobacter baumannii that was resistant to traditionally recommended therapies of amikacin and imipenem-cilastatin. the organism demonstrated minimum inhibitory concentrations ...200211939689
mima polymorpha infection.two cases of human infection by mima polymorpha are described. from these cases, and from the literature, it is concluded that this species is heterogeneous with respect to its biochemical properties. from comparative studies it is concluded that the genus mima is unrelated to the genus moraxella or to bacterium anitratum.196314015674
management of purulent pericarditis.a 50 year old man was admitted to icu due to purulent pericarditis, purulent inflammation of the soft tissue of the neck, purulent mediastinitis and pneumonia. subxyphoid periocardiotomy followed by the insertion of a drain into the pericardial space was performed. four other drains were also inserted to drain purulent fluid from the neck (two drains) and mediastinum (two drains). during the surgical procedure, 700 ml of purulent pericardial fluid from the pericardial sac and 200 ml of purulent ...200315148842
acinetobacter baumannii in human body louse.while we were isolating bartonella quintana from body lice, 40 acinetobacter baumannii strains were also isolated and genotyped. one clone was unique and the other was ampicillin susceptible. a. baumannii dna was later detected in 21% of 622 lice collected worldwide. these findings show an a. baumannii epidemic in human body lice.200415498175
the synthetic n-terminal peptide of human lactoferrin, hlf(1-11), is highly effective against experimental infection caused by multidrug-resistant acinetobacter baumannii.the lactoferrin-derived peptide hlf(1-11), but not its control peptide, was highly effective against five multidrug-resistant acinetobacter baumannii strains in vitro (3 to 4 log reduction) and against four of these strains in an experimental infection in mice (2 to 3 log reduction). therefore, this peptide is a promising candidate as a novel agent against infections with multidrug-resistant a. baumannii.200415561882
[splenic abscess in the course of infective endocarditis--report of a case].infective endocarditis is the most common condition predisposing a patient to splenic abscess. we report the case of man aged 65 who was admitted to the internal medicine department to diagnose the fever of unknown origin. the fever lasted longer than one year. clinical status and executed diagnostics, among others: echocardiography, blood cultures, abdominal ultrasonography, abdominal computed tomography allowed to give the diagnosis splenic abscess caused by acinetobacter baumanii in the cours ...200415773518
respiratory tract infection caused by bacteria (non-mycobacterium) and their antibiogram in hiv-positive patients.abstract. this study was undertaken from 1995-2000 to investigate the cause of respiratory tract infection among 481 patients with human immunodeficiency virus (hiv) at siriraj hospital, bangkok, thailand. the positive rate of bacterial pathogens was 38.46%. pseudomonas aeruginosa appeared to be the most common pathogen (32.97%), followed by staphylococcus aureus (18.92%), klebsiella pneumoniae (10.81 %), haemophilus influenzae (7.57%), and acinetobacter baumannii (5.95%). p. aeruginosa was sens ...200516124443
n-butanoyl-l-homoserine lactone (bhl) deficient pseudomonas aeruginosa isolates from an intensive care unit.acylated homoserine lactones (ahls) are self-generated diffusible signal molecules that mediate population density dependent gene expression (quorum sensing) in a variety of gram-negative bacteria, and several virulence genes of human pathogens are known to be controlled by ahls. in this study, strains of pseudomonas aeruginosa, acinetobacter baumannii, escherichia coli and klebsiella pneumoniae, isolated from intensive care patients, were screened for ahl production by using ahl responsive indi ...200516255145
adherence of acinetobacter baumannii strains to human bronchial epithelial cells.acinetobacter baumannii is an important nosocomial pathogen, but the mechanisms contributing to its epidemicity and virulence are largely unknown. the organism is able to colonize skin and mucosal surfaces of the human host. adherence of microorganisms to host cells is an important virulence factor as it is the initial step of the colonization process. in the present study, adherence of a. baumannii to human bronchial epithelial nci-h(292) cells was examined by light and scanning electron micros ...200616326077
experimental infection of human body lice with acinetobacter baumannii.the human body louse is currently recognized as a vector of rickettsia prowazekii, borrelia recurrentis, and bartonella quintana. previous studies have reported the isolation of acinetobacter baumannii from the body lice of homeless patients. to study how the body louse acquires a. baumannii, we infected a rabbit by infusing 2 x 10(6) colony-forming units of the louse strain of a. baumannii. two hundred body lice were infected by feeding on the bacteremic rabbit and compared with 200 uninfected ...200616606978
post-neurosurgical meningitis due to multidrug-resistant acinetobacter baumanii treated with intrathecal colistin: case report and review of the literature.intrathecal colistin (polymxin e) is becoming an important option for the treatment of post-neurosurgical meningitis caused by multidrug resistant (mdr) acinetobacter baumannii. we report a case of 28-year-old man who developed meningitis due to mdr a. baumannii associated with an external ventricular drain. the patient was cured using a 4-week course of intrathecal colistin 3.2 mg via external ventricular drain (evd) daily without any serious side effects.200617127235
acinetobacter baumannii lipopolysaccharides are potent stimulators of human monocyte activation via toll-like receptor 4 signalling.acinetobacter baumannii is a major nosocomial pathogen and frequent cause of hospital-acquired pneumonia, surgical wound infections and sepsis. as very little is known of the endotoxic potential of a. baumannii lipopolysaccharide (lps) with respect to human cells or of its ability to stimulate inflammatory signalling via human toll-like receptors (tlrs), the biological activity of these endotoxins was investigated in human monocytic thp-1 cells and in tlr-deficient hek-293 cells transfected with ...200717244795
comparative analysis of the bactericidal activities of amphibian peptide analogues against multidrug-resistant nosocomial bacterial strains.due to the widespread resistance of bacteria to the available drugs, the discovery of new classes of antibiotics is urgently needed, and naturally occurring antimicrobial peptides (amps) are considered promising candidates for future therapeutic use. amphibian skin is one of the richest sources of such amps. in the present study we compared the in vitro bactericidal activities of five amps from three different species of anurans against multidrug-resistant clinical isolates belonging to species ...200817954700
what is in the pipeline for gram-negative pathogens?the emergence of new human pathogens and increasing antimicrobial resistance in well-established pathogens are critical public health concerns. unfortunately, the pipeline of new antimicrobial candidates remains remarkably lean for molecules active against increasingly problematic gram-negative bacterial pathogens, such as acinetobacter baumannii and pseudomonas aeruginosa. although a number of new anti-gram-negative antibacterial agents are likely to be introduced soon for clinical use, they wi ...200818251663
global gene expression patterns and induction of innate immune response in human laryngeal epithelial cells in response to acinetobacter baumannii outer membrane protein a.the outer membrane protein a of acinetobacter baumannii (abompa) is an important pathogen-associated molecular pattern that induces host cell death. we determined the gene expression profiles of human laryngeal epithelial hep-2 cells in response to the sublethal concentration of recombinant abompa (rabompa) and investigated the molecular mechanisms by which rabompa induces an innate immune response. the microarray analysis showed that rabompa sequentially regulated a relatively small set of gene ...200818625015
gram-negative non-fermenting bacteria from food-producing animals are low risk for hospital-acquired infections.the aim of this study was to investigate possible indications of epidemiological relationships between pseudomonas aeruginosa and acinetobacter baumannii isolated from food-producing animals and those of clinical origin. screening for p. aeruginosa and a. baumannii isolates from food-producing animals was carried out on 1381 samples. susceptibility testing and pcr amplification of resistance genes were determined. isolate clonal relatedness was established by pfge. forty-one p. aeruginosa and 16 ...200819129067
tigecycline in combination with other antimicrobials: a review of in vitro, animal and case report studies.tigecycline has been investigated in combination with other antibacterials against a wide range of susceptible and multiresistant gram-positive and gram-negative bacteria. combinations have been analysed in vitro, in animal models and in human case reports. in vitro, tigecycline combined with other antimicrobials produces primarily an indifferent response (neither synergy nor antagonism). nevertheless, synergy occurred when tigecycline was combined with rifampicin against 64-100% of enterococcus ...200919162449
inhibition of multidrug-resistant acinetobacter baumannii by nonviral expression of hcap-18 in a bioengineered human skin tissue.when skin is compromised, a cascade of signals initiates the rapid repair of the epidermis to prevent fluid loss and provide defense against invading microbes. during this response, keratinocytes produce host defense peptides (hdps) that have antimicrobial activity against a diverse set of pathogens. using nonviral vectors we have genetically modified the novel, nontumorigenic, pathogen-free human keratinocyte progenitor cell line (niks) to express the human cathelicidin hdp in a tissue-specific ...200919190595
novel use of antimicrobial hand sanitizer in treatment of nosocomial acinetobacter infection.colonization of wounds with multidrug-resistant organisms is a difficult orthopedic problem. acinetobacter infections are especially difficult because they are resistant to all currently available antibiotics. we present the use of a novel skin sanitizer, stay byotrol clean (byotrol inc, spartanburg, south carolina), to treat a multidrug-resistant wound infection. a 31-year-old t10 paraplegic man presented with chronic bilateral stage iv decubitus trochanteric ulcers. cultures grew methicillin-r ...200919226024
evaluation of biofilm production, gelatinase activity, and mannose-resistant hemagglutination in acinetobacter baumannii strains.acinetobacter baumannii is an important nosocomial pathogen, but its pathogenic characteristics are not well defined. the purpose of this study was to evaluate biofilm production, mannose-resistant hemagglutination, and gelatinase production in a. baumannii strains isolated from various clinical specimens.200819255696
csua/babcde-dependent pili are not involved in the adherence of acinetobacter baumannii atcc19606(t) to human airway epithelial cells and their inflammatory response.acinetobacter baumannii is a nosocomial pathogen responsible for outbreaks of infection worldwide. the factors associated with its ability to colonize/infect human hosts are largely unknown. adherence to host cells is the first step in colonization/infection, which can be followed by biofilm formation. a. baumannii atcc19606(t) biofilm formation on abiotic surfaces depends on expression of the csua/babcde chaperonee-usher pili assembly system. the present study focused on the involvement of csua ...200919530313
continuous-infusion beta-lactam antibiotics during continuous venovenous hemofiltration for the treatment of resistant gram-negative describe the rationale, principles, and dosage calculations for continuous-infusion beta-lactam antibiotics to treat multidrug-resistant bacteria in patients undergoing continuous venovenous hemofiltration (cvvh).200919584386
acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations.acinetobacter baumannii is well adapted to the hospital environment, where infections caused by this organism are associated with significant morbidity and mortality. genetic determinants of antimicrobial resistance have been described extensively, yet the mechanisms by which a. baumannii regulates antibiotic resistance have not been defined. we sought to identify signals encountered within the hospital setting or human host that alter the resistance phenotype of a. baumannii. in this regard, we ...201020028819
streptococcus pneumoniae coinfection is correlated with the severity of h1n1 pandemic influenza.initial reports in may 2009 of the novel influenza strain h1n1pdm estimated a case fatality rate (cfr) of 0.6%, similar to that of seasonal influenza. in july 2009, however, argentina reported 3056 cases with 137 deaths, representing a cfr of 4.5%. potential explanations for increased cfr included virus reassortment or genetic drift, or infection of a more vulnerable population. virus genomic sequencing of 26 argentinian samples representing both severe and mild disease indicated no evidence of ...200920046873
genome-scale metabolic network analysis and drug targeting of multi-drug resistant pathogen acinetobacter baumannii aye.acinetobacter baumannii has emerged as a new clinical threat to human health, particularly to ill patients in the hospital environment. current lack of effective clinical solutions to treat this pathogen urges us to carry out systems-level studies that could contribute to the development of an effective therapy. here we report the development of a strategy for identifying drug targets by combined genome-scale metabolic network and essentiality analyses. first, a genome-scale metabolic network of ...201020094653
inactivation of phospholipase d diminishes acinetobacter baumannii pathogenesis.acinetobacter baumannii is an emerging bacterial pathogen of considerable health care concern. nonetheless, relatively little is known about the organism's virulence factors or their regulatory networks. septicemia and ventilator-associated pneumonia are two of the more severe forms of a. baumannii disease. to identify virulence factors that may contribute to these disease processes, genetically diverse a. baumannii clinical isolates were evaluated for the ability to proliferate in human serum. ...201020194595
dissection of host cell signal transduction during acinetobacter baumannii-triggered inflammatory response.infected airway epithelial cells up-regulate the expression of chemokines, chiefly il-8, and antimicrobial molecules including beta-defensins (bd). acinetobacter baumannii is a cause of hospital-acquired pneumonia. we examined whether a. baumannii induced the expressions of il-8 and bd2 by airway epithelial cells and the receptors implicated in bacterial detection. a549 and human primary airway cells released il-8 upon infection. a. baumannii-infected cells also increased the expression of bd2 w ...201020383325
do biofilm formation and interactions with human cells explain the clinical success of acinetobacter baumannii?the dramatic increase in antibiotic resistance and the recent manifestation in war trauma patients underscore the threat of acinetobacter baumannii as a nosocomial pathogen. despite numerous reports documenting its epidemicity, little is known about the pathogenicity of a. baumannii. the aim of this study was to obtain insight into the factors that might explain the clinical success of a. baumannii.201020505779
a study of cytotoxicity of novel chlorokojic acid derivatives with their antimicrobial and antiviral activities.a series of 6-chloromethyl-3-hydroxy-2-substituted 4h-pyran-4-one derivatives were synthesized and tested for their antimicrobial and antiviral activities. mannich base derivatives were prepared through the reaction of substituted piperazine or piperidine derivatives on chlorokojic acid and formaline. the structures of the synthesized compounds were confirmed by ir, (1)h and (13)c nmr, esi-ms, and elemental analysis. according to the activity studies, compounds 2-7 (mic: 1-2 microg/ml) were foun ...201020591538
potent and rapid bactericidal action of alyteserin-1c and its [e4k] analog against multidrug-resistant strains of acinetobacter baumannii.the emergence of multidrug-resistant strains of acinetobacter baumannii (mdrab) constitutes a serious threat to public health and necessitates the discovery of new types of antimicrobial agents. alyteserin-1c (glkeifkaglgslvkgiaahvas·nh(2)) is a cationic, α-helical peptide that was first isolated from skin secretions of the midwife toad alytes obstetricans. synthetic alyteserin-1c displayed potent activity against clinical isolates of mdrab (minimum inhibitory concentration, mic=5-10 μm; minimum ...201020603168
antimicrobial peptides with therapeutic potential from skin secretions of the marsabit clawed frog xenopus borealis (pipidae).nine peptides with differential growth inhibitory activity against escherichia coli and staphylococcus aureus were isolated from norepinephrine-stimulated skin secretions of the tetraploid frog xenopus borealis parker, 1936 (pipidae). structural characterization of the peptides demonstrated that they were orthologous to magainin-2 (1 peptide), peptide glycine-leucine-amide, pgla (2 peptides), caerulein-precursor fragments, cpf (4 peptides), and xenopsin-precursor fragments, xpf (2 peptides), pre ...201020656059
impact of pandemic influenza (h1n1) virus-associated community-acquired pneumonia among adults in a tertiary hospital in july 2009, a pandemic influenza (h1n1) (pdm h1n1) virus epidemic emerged rapidly in phitsanulok, thailand. adult cases of community-acquired pneumonia (cap) were prospectively examined for pdm h1n1 virus infections by real-time pcr in a tertiary hospital in phitsanulok from july to november 2009. twenty-four cases of pdm h1n1 virus-associated cap were confirmed, and their clinical features including bacterial infection, severity of disease, course of admission, treatment, and outcome were inv ...201020657064
chemical composition and antibacterial activities of illicium verum against antibiotic-resistant recent years, human pathogenic microorganisms have developed multiple drug resistance and caused serious nosocomial infections. in this study, we identified four new antimicrobial compounds from the chinese herbal medicine illicium verum and assessed their antibacterial efficacies. the supercritical co₂ and ethanol extracts of illicium verum showed substantial antibacterial activity against 67 clinical drug-resistant isolates, including 27 acinetobacter baumannii, 20 pseudomonas aeruginosa, a ...201020828316
[necrotizing fasciitis caused by acinetobacter baumannii : a case report].a 42-year-old man developed necrotizing fasciitis on the right leg. a multidrug-resistant acinetobacter baumannii was cultivated from the deep wound. following therapy with imipenem and tobramycin as well as extensive debridement, the lesions improved slowly. a. baumannii is today an important cause of nosocomial infections, especially in intensive care units.201120835812
biochemical and structural characterization of bisubstrate inhibitors of base, the self-standing nonribosomal peptide synthetase adenylate-forming enzyme of acinetobactin synthesis.the human pathogen acinetobacter baumannii produces a siderophore called acinetobactin that is derived from one molecule each of threonine, histidine, and 2,3-dihydroxybenzoic acid (dhb). the activity of several nonribosomal peptide synthetase (nrps) enzymes is used to combine the building blocks into the final molecule. the acinetobactin synthesis pathway initiates with a self-standing adenylation enzyme, base, that activates the dhb molecule and covalently transfers it to the pantetheine cofac ...201020853905
intravenous polyclonal igm-enriched immunoglobulin therapy for resistant acinetobacter sepsis in a pregnant patient with ards due to h1n1 infection. 201021111605
genome-assisted identification of putative iron-utilization genes in acinetobacter baumannii and their distribution among a genotypically diverse collection of clinical putative iron-uptake genes were identified in published genomes of the opportunistic human pathogen acinetobacter baumannii, and their occurrence was determined in a genotypically distinct collection of 50 clinical isolates by pcr and southern blot assays. the results demonstrated that all a. baumannii isolates tested share the coding potential for two endogenous siderophores, a heme-acquisition and a ferrous iron-uptake system. a second heme-uptake cluster was detected in almost two thirds ...201021144895
acinetobacter baumannii-induced lung cell death: role of inflammation, oxidative stress and cytosolic calcium.a growing body of evidence supports the notion that susceptible acinetobacter baumannii strain atcc 19606 induces human epithelial cells death. however, most of the cellular and molecular mechanisms associated with this cell death remain unknown, and also the degree of the cytotoxic effects of a clinical panresistant strain compared with a susceptible strain has never been studied. due to the role of proinflammatory cytokine release, oxidative stress and cytosolic calcium increase in the cell de ...201121288481
broad-spectrum antimicrobial efficacy of peptide a3-apo in mouse models of multidrug-resistant wound and lung infections cannot be explained by in vitro activity against the pathogens involved.although the designer proline-rich antimicrobial peptide a3-apo has only modest activity against escherichia coli and acinetobacter baumannii in vitro, in mouse models of systemic and wound infections it shows superior efficacy compared with conventional antibiotics. in this study, the efficacy of a3-apo in several additional mouse models was investigated, including staphylococcus aureus wound infection, mixed klebsiella pneumoniae-a. baumannii-proteus mirabilis wound infection and k. pneumoniae ...201121353493
innate immune responses to systemic acinetobacter baumannii infection in mice: neutrophils, but not il-17, mediate host resistance.acinetobacter baumannii is a nosocomial pathogen with a high prevalence of multiply drug resistant strains, causing pneumonia and sepsis. the current studies further develop a systemic mouse model of this infection and characterize selected innate immune responses to the organism. five clinical isolates, with varying degrees of antibiotic resistance, were assessed for virulence in two mouse strains, and between male and female mice, using intraperitoneal infection. nearly a 1000-fold difference ...201121576323
deciphering the multifactorial nature of acinetobacter baumannii pathogenicity.acinetobacter baumannii is an emerging bacterial pathogen that causes a broad array of infections, particularly in hospitalized patients. many studies have focused on the epidemiology and antibiotic resistance of a. baumannii, but little is currently known with respect to its virulence potential.201121829642
antimicrobial fibers: therapeutic possibilities and recent advances.the emergence of multi-drug-resistant bacteria such as methicillin-resistant strains of staphylococcus aureus (mrsa), vancomycin-resistant enterococci, pseudomonas aeruginosa, acinetobacter baumannii and extended-spectrum β-lactamase (carbapenemase)-producing enterobacteriaceae is becoming a serious threat. new-generation antimicrobial agents need to be developed. this includes the design of novel antimicrobial compounds and drug-delivery systems. this review provides an introduction into differ ...201122004087
comparative analysis of the complete genome of an acinetobacter calcoaceticus strain adapted to a phenol-polluted environment.the complete genome sequence of acinetobacter calcoaceticus phea-2, a non-pathogenic phenol-degrading bacterium previously isolated from industrial wastewater of an oil refinery in china, has been established. this is the first sequence of an a. calcoaceticus strain. we report here a comparative genomic analysis of phea-2 with two other acinetobacter species having different lifestyles, acinetobacter baumannii aye, a pathogenic human-adapted strain, and acinetobacter baylyi adp1, a soil-living s ...201122027104
ancient antimicrobial peptides kill antibiotic-resistant pathogens: australian mammals provide new overcome the increasing resistance of pathogens to existing antibiotics the 10×'20 initiative declared the urgent need for a global commitment to develop 10 new antimicrobial drugs by the year 2020. naturally occurring animal antibiotics are an obvious place to start. the recently sequenced genomes of mammals that are divergent from human and mouse, including the tammar wallaby and the platypus, provide an opportunity to discover novel antimicrobials. marsupials and monotremes are ideal poten ...201121912615
Generation of anti-tumour immune response using dendritic cells pulsed with carbonic anhydrase IX-Acinetobacter baumannii outer membrane protein A fusion proteins against renal cell carcinoma.Carbonic anhydrase IX (CA9), a specific molecular marker for renal cell carcinoma (RCC), serves as a potential target for RCC-specific immunotherapy using dendritic cells (DCs). However, pulsing of DCs with CA9 alone is not sufficient for generation of a therapeutic anti-tumour immune response against RCC. In this study, in order to generate a potent anti-tumour immune response against RCC, we produced recombinant CA9-Acinetobacter baumannii outer membrane protein A (AbOmpA) fusion proteins, des ...201222132887
Pharmacokinetic and pharmacodynamic evaluation of tigecycline.INTRODUCTION: As the spread of multidrug-resistant (MDR) and extensive drug-resistant (XDR) organisms constitutes a real threat for patients, new antimicrobials are needed. Tigecycline, the first-in-class glycylcycline, possesses an extended spectrum of antimicrobial activity including MDR and XDR organisms, which holds promise as a treatment option beyond currently approved indications and deserves expanded evaluation of its pharmacokinetics/pharmacodynamics (PK/PD). AREAS COVERED: This review ...201121958044
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