| leptospirosis in rodents from an arid environment. | rodents (n = 358) were trapped from 6 locations in arizona, including 2 dairies, 2 swine raising operations, and 2 areas where domestic animal access was limited. isolates of leptospira interrogans serovar ballum were obtained from 3 house mice (mus musculus) trapped in dairies. leptospira were seen in silver-stained kidney sections of 10.4% of the rodents. the usefulness of serologic data in detecting leptospiral infection in these rodents was uncertain because so few animals yielded isolates t ... | 1983 | 6638656 |
| seroepidemiological survey of rodents collected at a u.s. military installation, yongsan garrison, seoul, republic of korea. | a seroepidemiological study of selected rodent-borne diseases (hantavirus [seoul [seo] virus], scrub typhus [orientia tsutsugamushi], murine typhus [rickettsia typhi], and leptospirosis [leptospira interrogans]), as part of the u.s. military rodent surveillance and control program, was conducted from 2001 through 2005 at yongsan garrison, seoul, republic of korea. rodents were collected to determine the prevalence of rodent-borne diseases at a u.s. military installation in an urban environment. ... | 2007 | 17691691 |
| [upregulation of fasl/fas expression and fasl/fas-associated apoptosis in j774a.1 cells induced by leptospira interrogans]. | to determine the involvement of fasl/fas pathway in apoptosis of j774a.1 cells induced by leptospira interrogans. | 2008 | 19084951 |
| [j774a.1 cell apoptosis induced by leptospira interrogans and effects of caspase-3, -6 activation on apoptosis]. | to investigate the apoptosis of j774a.1 cells induced by leptospira interrogans and the effect of caspase-3, -6 activation on the apoptosis. | 2008 | 19084952 |
| experimental infection in tumor necrosis factor alpha receptor, interferon gamma and interleukin 4 deficient mice by pathogenic leptospira interrogans. | only recently, knockout mouse models were applied in studies on the pathogenesis of leptospirosis. current data suggest an important role of innate immunity receptors and interferon gamma dependant cellular response on protection. it is not clear, however, whether t helper cell polarization influences on outcome of leptospiral infection. we report findings of experimental infection of c57bl/6 (interferon gamma or tumor necrosis factor alpha receptor deficient) and balb/c (interleukin 4 deficient ... | 2008 | 17991451 |
| differential tlr recognition of leptospiral lipid a and lipopolysaccharide in murine and human cells. | leptospira interrogans is a spirochete that is responsible for leptospirosis, a zoonotic disease. this bacterium possesses an unusual lps that has been shown to use tlr2 instead of tlr4 for signaling in human cells. the structure of its lipid a was recently deciphered. although its overall hexa-acylated disaccharide backbone is a classical feature of all lipid a forms, the lipid a of l. interrogans is peculiar. in this article, the functional characterization of this lipid a was studied in compa ... | 2005 | 16237097 |
| leptospiral colonial morphology. | stalheim, o. h. v. (university of wisconsin, madison) and j. b. wilson. leptospiral colonial morphology. j. bacteriol. 86:482-489. 1963.-a sequence of apparent colonial types was observed with colonies of leptospira pomona, l. canicola, l. icterohaemorrhagiae, and l. grippotyphosa in agar medium. although some colonies of these serotypes had a different appearance initially, they eventually developed the mature or final appearance characteristic of the serotype. colonies of freshly isolated, vir ... | 1963 | 14066425 |
| first epidemiological data on pathogenic leptospires isolated on the azorean islands. | insectivores (erinaceus europaeus) and rodents (rattus rattus, r. norvegicus and mus musculus) from different islands of the azores archipelago were found to carry three distinct leptospira interrogans s.l. serovars (copenhageni, icterohaemorrhagiae and ballum) which have never been previously investigated there. the house mouse and the black rat were the major leptospira reservoirs showing isolation rates ranging from 0% for both species (in graciosa) to 88% and 33%, respectively (in sãao migue ... | 1997 | 9258550 |
| the possible role of the common field mouse (mus musculus) in the epidemiology of leptospirosis in pigs. | | 1982 | 7126066 |
| the role of macrophages in the protection of mice against leptospirosis: in vitro and in vivo studies. | balb/c mice are naturally resistant to infection with leptospira interrogans serovar copenhageni, but leptospires were not phagocytosed by mouse peritoneal macrophages in vitro without added specific antibody. similar results were obtained irrespective of whether leptospires were viable or killed, virulent or avirulent, or whether macrophages were obtained from normal mice, immunized mice or mice previously infected with bcg. suppression or stimulation of macrophage function in vivo did not affe ... | 1982 | 6760092 |
| [a type strain or a neotype strain of leptospira]. | a deep review of the scientific literature concerning the history of the two oldest icterohaemorrhagiae strains is given in order to promote a decision about the legitimate neotype strain on the genus leptospira. the strain rga was found to meet completely the requirements for a neotype culture given by the international code of nomenclature of bacteria. its origin from a patient with weil's disease through guinea pig passages in 1915 is well documented and its culture is unequivocally described ... | 1984 | 6380158 |
| species- and genus-specific antigens in leptospira, revealed by monoclonal antibodies and enzyme immunoassay. | mouse antisera to leptospira interrogans serovar pomona or l. biflexa serovar patoc agglutinated homologous leptospires but not leptospires of serovars from any heterologous serogroup tested. when tested by enzyme immunoassay (eia), pomona and patoc antisera reacted with all serovars tested from l. interrogans, l. biflexa or l. illini species. a non-agglutinating hybridoma-derived monoclonal antibody reacted by eia only with serovars of the pathogenic l. interrogans species but not with l. bifle ... | 1983 | 6359778 |
| opsonic monoclonal antibodies against lipopolysaccharide antigens of leptospira interrogans serovar hardjo. | six monoclonal antibodies produced from mice immunised with leptospira interrogans serovar hardjo were directed against determinants in the leptospiral lipopolysaccharide, as indicated by immunodiffusion and enzyme immunoassay (eia), and opsonised leptospires for phagocytosis by mouse macrophages. their specificities were studied by agglutination and eia. five antibodies reacted with some, but not all, members of the sejroe and hebdomadis serogroups, and one antibody agglutinated exclusively mem ... | 1987 | 3820267 |
| a survey of zoonotic pathogens carried by house mouse and black rat populations in yucatan, mexico. | the house mouse (mus musculus) and the black rat (rattus rattus) are reservoir hosts for zoonotic pathogens, several of which cause neglected tropical diseases (ntds). studies of the prevalence of these ntd-causing zoonotic pathogens, in house mice and black rats from tropical residential areas are scarce. three hundred and two house mice and 161 black rats were trapped in 2013 from two urban neighbourhoods and a rural village in yucatan, mexico, and subsequently tested for trypanosoma cruzi, hy ... | 2017 | 28689507 |
| first isolates of leptospira spp., from rodents captured in angola. | rodents play an important role in the transmission of pathogenic leptospira spp. however, in angola, neither the natural reservoirs of these spirochetes nor leptospirosis diagnosis has been considered. regarding this gap, we captured rodents in luanda and huambo provinces to identify circulating leptospira spp. rodent kidney tissue was cultured and dna amplified and sequenced. culture isolates were evaluated for pathogenic status and typing with rabbit antisera; polymerase chain reaction (pcr) a ... | 2016 | 26928840 |
| different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes. | the mouse disease model has the advantage of a broad array of immunological and genetic tools available for basic research. some studies on transgenic and/or mutant mouse strains as models for experimental leptospirosis have been reported; however, the wider use of such models is hampered by a poor understanding of the outcome of experimental leptospiral infection among the different mouse strains available. here, the outcome of infection by a virulent strain of leptospira interrogans serogroup ... | 2010 | 20558584 |
| replication or death: distinct fates of pathogenic leptospira strain lai within macrophages of human or mouse origin. | pathogenic leptospires evoke severe diseases in humans but only cause mild chronic or asymptomatic infection in many host animals. the reasons for this diversity of infection remain unclear. here, we demonstrated that leptospira interrogans serovar lai strain lai had a similar ability to adhere to and enter primary and immortal (thp-1 and j774a.1) macrophages from human and mouse, but its intracellular fate in human macrophages differed markedly from that in mouse. the leptospires resided within ... | 2010 | 19587003 |
| [adhering effect of leptospira interrongan to major extracellular matrix molecules]. | to determine the adhering ability of leptospira interrogans to extracellular matrix molecules (ecm) of host cells and its diversity. | 2008 | 19084955 |