| definition of three serotypes of hantaviruses by a double sandwich elisa with biotin-avidin amplification system. | a total of seven different isolates of hantaviruses from five mammalian species and six geographical areas were examined by a double sandwich elisa with biotin-avidin amplification system. three serotypes were recognized by comparing antigen titres to homologous and heterologous antibody and blocking antibody titres to homologous and heterologous antigens. serotype 1 included four strains: hantaan virus isolated from apodemus agrarius in south korea, hupei-i isolated from acute-phase serum from ... | 1985 | 3926952 |
| genetic diversity of apodemus agrarius-borne hantaan virus in korea. | hantaan (htn) virus, the etiologic agent of clinically severe hemorrhagic fever with renal syndrome (hfrs), was first isolated in 1976 from lung tissues of striped field mice (apodemus agrarius) captured in songnae-ri, kyungki-do, korea. to clarify the genetic diversity and phylogenetic relationship among korean strains of htn virus, viral sequences of the partial s and m segments were amplified from lung tissues of 24 seropositive striped field mice captured between 1989 and 1998 at 11 sites in ... | 2000 | 11129640 |
| epidemiological progresses of hemorrhagic fever with renal syndrome in china. | to summarize the major achievements of chinese work on the epidemiology and prevention of hemorrhagic fever with renal syndrome (hfrs) in recent years, and to give a general review on the present situation of hfrs in china. | 1999 | 11593522 |
| [report on epidemic hemorrhagic fever (ehf) surveillance in 1999]. | to understand the epidemic tread of epidemic hemorrhagic fever (ehf) in 1999 and to develop programs for its control and prevention. | 2000 | 11860833 |
| hantaan virus infection causes an acute neurological disease that is fatal in adult laboratory mice. | hantaan virus, the etiological agent of korean hemorrhagic fever, is transmitted to humans from persistently infected mice (apodemus agrarius), which serve as the primary reservoir. here we demonstrate that several strains of adult mus musculus domesticus (c57bl/6, balb/c, akr/j, and sjl/j) were susceptible to hantaan virus infection when infected intraperitoneally. first clinical signs were loss of weight, ruffled fur, and reduced activity, which were followed by neurological symptoms, such as ... | 2002 | 12163608 |
| [surveillance on hemorrhagic fever with renal syndrome in guizhou during 1984-2000]. | to explore the relations between different areas on hemorrhagic fever with renal syndrome (hfrs) in guizhou. | 2003 | 14521790 |
| ecological surveillance of small mammals at dagmar north training area, gyeonggi province, republic of korea, 2001-2005. | a seasonal rodent-borne disease surveillance program was established at dagmar north training area located near the demilitarized zone, republic of korea, from 2001 through 2005. selected habitats surveyed included earthen banks separating rice paddies, fighting positions along a 5 m rock-faced earthen berm, and extensive tall grasses with various degrees of herbaceous and scrub vegetation associated with dirt roads, rice paddies, ditches, ponds, or the imjin river. of the nine species of small ... | 2011 | 21635640 |
| Hantaan virus surveillance targeting small mammals at Dagmar North Training Area, Gyeonggi Province, Republic of Korea, 2001-2005. | In response to a hemorrhagic fever with renal syndrome case in November 2000, a seasonal rodent-borne disease surveillance program was initiated at Dagmar North Training Area (DNTA), Gyeonggi Province, Republic of Korea. From April 2001-December 2005, 1,848 small mammals were captured. Apodemus agrarius accounted for 92.5%, followed by Mus musculus (3.6%), Crocidura lasiura (2.1%), and Microtus fortis (1.1%). Three species of rodents were found to be antibody-positive (Ab+) for Hantaan virus (HT ... | 2011 | 22129409 |
| prevalence of hantavirus infection in wild rodents from five provinces in korea, 2007. | hemorrhagic fever with renal syndrome (hfrs) is an infectious disease caused by hantaviruses of the family bunyaviridae. among them, hantaan virus (htnv) is most widely distributed in korea. the striped field mouse, apodemus agrarius, is the natural host of htnv in rural korea. we trapped 766 small mammals of three species (1 eothenomys regulus, 13 crocidura suaveolens, and 752 apodemus agrarius) in five provinces in korea from january to december 2007. we tested 542 rodent sera for htnv antibod ... | 2011 | 21441196 |
| ecology of hantaan virus at twin bridges training area, gyeonggi province, republic of korea, 2005-2007. | the twin bridges training area (tbta) in the republic of korea consists of dirt roads, barren training areas, and forested hillsides adjacent to linear and broad expanses of tall grasses, herbaceous, and scrub vegetation. of the six species of small mammals, the striped field mouse, apodemus agrarius, was the most frequently captured (96.1%). apodemus agrarius capture rates varied from 17.7 to 33.2% during three trapping periods. gravid females were observed during november-december 2006 (8.4%) ... | 2009 | 20836826 |
| hantavirus infections in humans and animals, china. | hemorrhagic fever with renal syndrome (hfrs) is a serious public health problem in the people's republic of china. although 7 sero/genotypes of hantaviruses have been found in rodents, only hantaan virus (carried by apodemus agrarius mice) and seoul virus (carried by rattus norvegicus rats) reportedly cause disease in humans. during 1950-2007, a total of 1,557,622 cases of hfrs in humans and 46,427 deaths (3%) were reported in china. hfrs has been reported in 29 of 31 provinces in china. after i ... | 2010 | 20678311 |
| hemorrhagic fever with renal syndrome in 4 us soldiers, south korea, 2005. | four us soldiers acquired hemorrhagic fever with renal syndrome while training near the demilitarized zone, south korea, in 2005. hantaan virus sequences were amplified by reverse transcription-pcr from patient serum samples and from lung tissues of striped field mice (apodemus agrarius) captured at training sites. epidemiologic investigations specified the ecology of possible sites of patient infection. | 2009 | 19891878 |
| co-circulation of three pathogenic hantaviruses: puumala, dobrava, and saaremaa in hungary. | hantaviruses (bunyaviridae) cause hemorrhagic fever with renal syndrome (hfrs) in eurasia and hantavirus (cardio)pulmonary syndrome (hcps) in the americas. hfrs is caused by hantaan virus (htnv), seoul virus (seov), dobrava virus (dobv), saaremaa virus (saav), and puumala virus (puuv). of those, only htnv is not present in europe. in recent years, hantaviruses, described in other parts of europe, were also detected at various locations in hungary. to study the genetic properties of hungarian han ... | 2009 | 19856478 |
| [serological characteristics of hantaviruses from clinical specimens analyzed in 1998-2008 in the department of virology, public health institute, ostrava]. | in 1998 - 2008, serum samples from 464 patients, predominantly residents of the moravia-silesian region, were examined in the department of virology, public health institute in ostrava, using enzyme-linked immunosorbent assay (elisa) for the detection of specific anti-hantavirus antibodies. seropositivity was ascertained in 41 persons (8.8%). more patients tested seropositive against hantaan virus (24, i.e. 58.5%) than against puumala virus (13, i.e. 31.7%). four persons were reactive against bo ... | 2009 | 19750821 |
| hantaviruses in rodents and humans, inner mongolia autonomous region, china. | surveys were carried out in 2003-2006 to better understand the epidemiology of hantaviruses in the inner mongolia autonomous region of china (inner mongolia). hemorrhagic fever with renal syndrome (hfrs) was first reported in this region in 1955 and has been an important public health problem here since then. during 1955-2006, 8,309 persons with hfrs were reported in inner mongolia (average incidence rate 0.89/100,000), and 261 (3.14%) died. before the 1990s, all hfrs cases occurred in northeast ... | 2009 | 19523286 |
| ecological surveillance of small mammals at firing points 10 and 60, gyeonggi province, republic of korea, 2001-2005. | throughout korea, small mammals are hosts to a number of disease-causing agents that pose a health threat to u.s. and korean military forces while they conduct field-training exercises. a seasonal rodent-borne disease surveillance program was established at two firing points (fp), fp-10, and fp-60, and conducted over five years from 2001 through 2005 in response to hantavirus cases among u.s. soldiers. the ecology of these sites consisted primarily of tall grasses associated with semi-permanent ... | 2008 | 19263858 |
| molecular diversity and phylogeny of hantaan virus in guizhou, china: evidence for guizhou as a radiation center of the present hantaan virus. | to gain further insight into the molecular epidemiology of hantaan virus (htnv) in guizhou, china, rodents were captured in this region in 2004 and 2005. in addition, serum samples were collected from four patients. ten hantaviruses were isolated successfully in cell culture from four humans, two apodemus agrarius, three rattus norvegicus and one rattus nitidus. the nucleotide sequences for their small (s), medium (m) and partial large (l) segments were determined. phylogenetic analysis of the s ... | 2008 | 18632971 |
| bovine aortic endothelial cells are susceptible to hantaan virus infection. | hantavirus serotype hantaan (htn) is one of the causative agents of hemorrhagic fever with renal syndrome (hfrs, lethality up to 10%). the natural host of htn is apodemus agrarius. recent studies have shown that domestic animals like cattle are sporadically seropositive for hantaviruses. in the present study, the susceptibility of bovine aortic endothelial cells (baec) expressing alpha(v)beta(3)-integrin to a htn infection was investigated. viral nucleocapsid protein and genomic rna segments wer ... | 2004 | 15033559 |
| short report: simultaneous occurrence of dobrava, puumala, and tula hantaviruses in slovakia. | the prevalence of antibody to hantaviruses in slovakia (serum panel n = 2,133) was lower in the western part (0.54%) and higher in the eastern part (1.91%) of the country and was found to be significantly enhanced in a group of forest workers from eastern slovakia (5.88%). one-third of the igm-negative convalescent phase sera from patients with hemorrhagic fever with renal syndrome exhibited antibodies reacting predominantly with puumala virus antigen, while two-thirds had antibodies directed ma ... | 1999 | 10497981 |
| isolation and characterization of dobrava hantavirus carried by the striped field mouse (apodemus agrarius) in estonia. | dobrava hantavirus (dob) was isolated from the striped field mouse (apodemus agrarius) trapped on saaremaa island, estonia, and its genetic and antigenic characteristics were subsequently analysed. phylogenetic analysis showed that the estonian dob strain, together with several wild strains carried by apodemus agrarius, forms a well-supported lineage within the dob clade. the topography of the trees calculated for the s, m and l nucleotide sequences of the estonian dob suggests a similar evoluti ... | 1999 | 10073697 |
| seroepidemiology of hantaan virus infection in taiwan. | in order to investigate the infection rate of hantaan virus in taiwan, a total of 6,536 human serum samples were collected from residents, selected by stratified random sampling, from 19 townships covering four different ethnic groups: aborigines, fukien taiwanese, hakka taiwanese, and mainland chinese. serum samples were screened for hantaan virus antibodies by indirect immunofluorescence. the prototype hantaan virus (76/118)-infected vero e6 cells were used as the viral antigen for the antibod ... | 1996 | 8950687 |
| a serotypic study of hemorrhagic fever with renal syndrome in rural china. | apodemus agrarius was trapped in the fields and rattus norvegicus was trapped within the houses in the villages of jiande county, a region in the zhejiang province of china endemic for hemorrhagic fever with renal syndrome (hfrs). antibodies to hantaviruses were detected in three (16.7%) of 18 a. agrarius and 12 (13.5%) of 89 r. norvegicus, whereas hantavirus antigens were detected in the lung tissues of four (22.2%) of 18 and nine (10.1%) of 89 of these rodents, respectively. three hantaviruses ... | 1995 | 7694967 |
| antigenic differences between two viruses, isolated in japan and korea, that cause hemorrhagic fever with renal syndrome. | hantaan virus (hv) 76-118, isolated from apodemus agrarius coreae in korea, and hemorrhagic fever with renal syndrome (hfrs) virus b-1, isolated from a rat in japan, were examined for polypeptide compositions and for differences in immune responses in rats. in immunoprecipitation experiments, a major polypeptide of ca. 50 kilodaltons (k) was detected with antisera against hv 76-118 in cell extracts from vero e6 cells infected with hfrs virus b-1, whereas three major polypeptides of 74 k (glycosy ... | 1984 | 6207309 |
| disseminated intravascular coagulation in korean hemorrhagic fever. | to investigate the nature and role of coagulation and complement alterations in the pathogenesis of korean hemorrhagic fever (khf), the profiles from the early stages in 27 male patients were serially evaluated. evidence of disseminated intravascular coagulation (dic) was observed in 14 of the 27 patients (51.8%) sometime during the course of the disease. the earlier the coagulation tests were performed, the more frequently the evidence of dic was found. the mean serum c3 concentration was signi ... | 1983 | 6141786 |
| host and viral traits predict zoonotic spillover from mammals. | the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ... | 2017 | 28636590 |
| muroid virus nephropathies and muroid viruses of the hantaan virus group. | hemorrhagic fever with renal syndrome (hfrs) came dramatically to the attention of western medicine in 1951 with the "new" disease becoming a major source of morbidity and mortality in american troops in korea. known there as epidemic hemorrhagic fever (ehf) or korean hemorrhagic fever (khf), it became apparent that it was the same disease as the endemic (epidemic) hemorrhagic nephroso-nephritis of the soviet far east and songo fever of the japanese army in manchuria. the conjecture that the mil ... | 1982 | 6134336 |
| hantavirus rna prevalence in myomorph rodents on bolshoy ussuriysky island at the sino-russian border. | to understand the distribution and infection status of hantavirus in myomorph rodents on bolshoy ussuriysky island (heixiazi island) at the sino-russian border, and to provide data for the safe development and utilization of bolshoy ussuriysky island. | 2017 | 28678679 |
| isolation of hantaan virus, the etiologic agent of korean hemorrhagic fever, from wild urban rats. | urban rats captured in seoul and four nearby korean cities were found to have immunofluorescent antibodies reactive with hantaan virus, the etiologic agent of korean hemorrhagic fever (khf). serum antibodies were detected in 13% from 477 rattus norvegicus and 11% of 47 rattus rattus. hantaan viral antigen was found in pulmonary tissues of 42 animals, and hantaan virus was recovered from 23 rats, all but two of which were r. norvegicus. wistar rats were qualitatively much more sensitive than apod ... | 1982 | 6127366 |
| intraspecific transmission of hantaan virus, etiologic agent of korean hemorrhagic fever, in the rodent apodemus agrarius. | experimental parameters of infection and intraspecific transmission of hantaan virus, the etiologic agent of korean hemorrhagic fever, in apodemus agrarius rodents were determined. mice inoculated by the intramuscular route experienced viremia for about 1 week beginning on day 7. after 3 weeks, immunofluorescent and neutralizing antibodies were present and no mouse ever developed signs of acute illness. virus was recovered from lung, kidney, salivary gland, and liver, and virus excretion in urin ... | 1981 | 6116436 |
| propagation of korean hemorrhagic fever virus in laboratory rats. | korean hemorrhagic fever virus (khfv) has been adapted to the wistar and fisher strains of rats. infection was detected by the appearance of specific antigen in the lung tissue of the infected rats at 14 to 64 days after inoculation and by the appearance of circulating antibodies in ther serum which reacted specifically with khfv antigen in the lungs of infected apodemus agrarius subsp. coreae 3 weeks after inoculation. distribution of antigen in rat tissues as determined by immunofluorescent st ... | 1981 | 6111538 |
| pathogenesis of experimental hantaan virus infection in laboratory rats. | weanling fischer rats inoculated intramuscularly with hantaan virus (strain 76-118) developed subclinical infections characterized by transient viremia and shedding of virus in saliva, persistence of virus in lung, pancreas, spleen and liver, and development of fluorescent and neutralizing antibodies in serum with immune complex deposition in lung. viremia and virus shedding in saliva occurred 10 to 13 days after inoculation. horizontal intracage transmission of infection occurred between 35 and ... | 1986 | 2869749 |
| experimental infection with puumala virus, the etiologic agent of nephropathia epidemica, in bank voles (clethrionomys glareolus). | subclinical chronic infections characterized by transient viremia, prolonged virus shedding in oropharyngeal secretions and feces, and virus persistence in tissues (particularly lung) developed in laboratory-bred weanling bank voles (clethrionomys glareolus) inoculated intramuscularly with puumala virus (strain hällnäs), the etiologic agent of nephropathia epidemica. viral antigen, as evidence by granular fluorescence, was detected in the lungs, liver, spleen, pancreas, salivary glands, and smal ... | 1985 | 2861296 |
| dobrava-belgrade hantavirus from germany shows receptor usage and innate immunity induction consistent with the pathogenicity of the virus in humans. | dobrava-belgrade virus (dobv) is a european hantavirus causing hemorrhagic fever with renal syndrome (hfrs) in humans with fatality rates of up to 12%. dobv-associated clinical cases typically occur also in the northern part of germany where the virus is carried by the striped field mouse (apodemus agrarius). however, the causative agent responsible for human illness has not been previously isolated. | 2012 | 22545121 |
| infection of hantaan virus strain aa57 leading to pulmonary disease in laboratory mice. | hantaan virus (htnv) is a causative agent of hemorrhagic fever with renal syndrome (hfrs). the pathogenesis of hfrs has not been fully elucidated, mainly due to the lack of a suitable animal model. in laboratory mice, htnv causes encephalitis. however, that symptom is dissimilar to human hantavirus infections. we found that htnv strain aa57 (isolated from apodemus agrarius in far east russia) caused pulmonary disease in 2-week-old icr mice. the clinical signs of the infected mice were piloerecti ... | 2011 | 22044619 |
| Genetic analysis of hantaviruses and their rodent hosts in central-south China. | Hantaan virus (HTNV) and Seoul virus (SEOV) are two major zoonotic pathogens of hemorrhagic fever with renal syndrome (HFRS) in Asia. Hubei province, which is located in the central-south China, had been one of the most severe epidemic areas of HFRS. To investigate phylogenetic relationships, genetic diversity and geographic distribution of HTNV and SEOV in their reservoir hosts, a total of 687 rodents were trapped in this area between 2000 and 2009. Sequences of partial S- and M-segments of han ... | 2011 | 22108583 |
| isolation of the etiologic agent of korean hemorrhagic fever. | lung tissues from 73 rodents (apodemus agrarius coreae) gave specific immunofluorescent reactions when they reacted with sera from patients convalescing from korean hemorrhagic fever. similar staaining was observed in the lungs of a. agrarius inoculated with acute-phase sera obtained from two patients with this disease. the unidentified agent was successfully propagated in adult a. agrarius through eight passages representing a cumulative dilution of greater than 10(-17). experimentally inoculat ... | 1978 | 24670 |
| sequence-independent, single-primer amplification next-generation sequencing of hantaan virus cell culture-based isolates. | hantaan virus (htnv), identified in the striped field mouse (apodemus agrarius), belongs to the genus hantavirus of the family bunyaviridae and contains tripartite rna genomes, small (s), medium (m), and large (l) segments. htnv is a major causative for hemorrhagic fever with renal syndrome (hfrs) with fatality rates ranging from 1% to 15% in the republic of korea (rok) and china. defining of htnv whole-genome sequences and isolation of the infectious particle play a critical role in the charact ... | 2017 | 27895275 |
| prevalence of hemorrhagic fever with renal syndrome in qingdao city, china, 2010-2014. | hemorrhagic fever with renal syndrome (hfrs) was considered to be transmitted by apodemus agrarius and rattus norvegicus, the principal animal hosts of hantaan virus and seoul virus, respectively. the aim of this study is to determine the correlation of hfrs incidence with capture rate and hantavirus infection rate of rodent species in qingdao city, china. we collected hfrs patients' information and captured field and residential rodents in qingdao city, china from 2010 to 2014. the correlations ... | 2016 | 27786303 |
| genetic diversity and reassortment of hantaan virus tripartite rna genomes in nature, the republic of korea. | hantaan virus (htnv), a negative sense tripartite rna virus of the family bunyaviridae, is the most prevalent hantavirus in the republic of korea (rok). it is the causative agent of hemorrhagic fever with renal syndrome (hfrs) in humans and maintained in the striped field mouse, apodemus agrarius, the primary zoonotic host. clinical hfrs cases have been reported commonly in hfrs-endemic areas of gyeonggi province. recently, the death of a member of the rok military from gangwon province due to h ... | 2016 | 27315053 |
| hemorrhagic fever with renal syndrome, zibo city, china, 2006-2014. | analysis of hemorrhagic fever with renal syndrome cases in zibo city, china, during 2006-2014 showed that it occurred year-round. peaks in spring and fall/winter were caused by hantaan and seoul viruses, respectively. rodent hosts were the striped field mouse for hantaan virus and the brown rat and house mouse for seoul virus. | 2016 | 26812444 |
| hantaan virus surveillance targeting small mammals at nightmare range, a high elevation military training area, gyeonggi province, republic of korea. | rodent-borne disease surveillance was conducted at nightmare range (nm-r), near the demilitarized zone in northeast gyeonggi province, republic of korea, to identify hemorrhagic fever with renal syndrome (hfrs) risks for a mountainous high-elevation (500 m) military training site. monthly surveys were conducted from january 2008-december 2009. a total of 1,720 small mammals were captured belonging to the orders rodentia [families, sciuridae (1 species) and muridae (7 species)] and soricomorpha [ ... | 2015 | 25874643 |
| co-circulation of hantaan, kenkeme, and khabarovsk hantaviruses in bolshoy ussuriysky island, china. | hemorrhagic fever with renal syndrome (hfrs) was first recognized in far eastern asia in the 1930s, and has been highly prevalent in this region ever since. to reveal the molecular epidemiology of hantaviruses in this region, a total of 374 small mammals (eight species of rodents and one species of shrew) were captured in the chinese part of the bolshoy ussuriysky island (heilongjiang province). hantavirus sequences were recovered from three striped field mice (apodemus agrarius), 11 maximowicz' ... | 2014 | 25087879 |
| epidemic characteristics of hemorrhagic fever with renal syndrome in china, 2006-2012. | hemorrhagic fever with renal syndrome (hfrs) caused by hantaviruses is a serious public health problem in china. the national notifiable disease surveillance system (nndss) was established online by china cdc in 2004 and rodent surveillance sites were adjusted to 40 sites in 22 provinces in 2005. here we analyzed the surveillance data of both human cases and rodents host during 2006-2012 to examine the epidemic trends of hfrs in recent years in china. | 2014 | 25012160 |
| [the analysis of hantavirus s gene in apodemus agrarius in changbai area]. | to gain more insights into epidemiologic characteristics and genotype of hantavirus in apodemus agrarius in changbai area. complete hantavirus s segment sequences were amplified by rt-pcr and sequenced. the phylogenetic trees were constructed for analysis of genetic characters of hantavirus. a total of 58 apodemus agrarius were trapped in the epidemic areas, and complete hantavirus s segment sequences were obtained from 4 lung samples of these rodents (6. 90%0). phylogenetic analysis of the four ... | 2013 | 23895001 |
| an efficient method for isolation of hantaan virus through serial passages in suckling mice. | hantaan virus (htnv) is one of the main etiologic agents for hemorrhagic fever with renal syndrome in china. however, it is very difficult to isolate the virus from its original host, which hampers the viral characterization. this study describes an efficient method for isolating htnv in suckling mice. | 2013 | 23306793 |
| cross-species transmission in the speciation of the currently known murinae-associated hantaviruses. | to gain more insight into the phylogeny of dabieshan virus (dbsv), carried by niviventer confucianus and other murinae-associated hantaviruses, genome sequences of novel variants of dbsv were recovered from niviventer rats trapped in the mountainous areas of wenzhou, china. genetic analyses show that all known genetic variants of dbsv, including the ones identified in this study, are distinct from other murinae-associated hantaviruses. dbsv variants show geographic clustering and high intraspeci ... | 2012 | 22855492 |
| hantaviruses in rodents and humans, xi'an, pr china. | xi'an, the capital of shaanxi province, located in north-west china, is one of the major endemic areas for haemorrhagic fever with renal syndrome (hfrs). in this study, the epidemiological data of hfrs in xi'an from 1959 to 2010, especially in the past ten years (2001-2010), were surveyed. the features of hantavirus (hv) host carriers, the molecular characteristics of the hv s gene from hosts and patients, and the genome of the viral isolate were also investigated. data showed that there might b ... | 2012 | 22837422 |
| genetic characterization of a new subtype of hantaan virus isolated from a hemorrhagic fever with renal syndrome (hfrs) epidemic area in hubei province, china. | to characterize hantaviruses currently circulating in the hemorrhagic fever with renal syndrome (hfrs) epidemic area of hubei province, rodents were captured and serum samples were collected from several hfrs patients. the partial s segment of the hantaviruses amplified from two serum samples had a high degree of sequence identity to the corresponding hantavirus strain isolated from apodemus agrarius (designated as hv004). the complete s, m, and l segment sequences of hv004 were determined. the ... | 2012 | 22718221 |
| hantaan virus surveillance in small mammals at firing points 10 and 60, yeoncheon, gyeonggi province, republic of korea. | we used epidemiological data and indirect fluorescent antibody tests to determine the hantaan virus (htnv) antibody-positive (ab+) prevalence in small mammals captured at firing point 10 (fp-10) and firing point 60 (fp-60), gyeonggi province, near the demilitarized zone, republic of korea (rok), from 2001 to 2005. we used these data, combined with the partial m segment amplified from htnv recovered from lung tissues of apodemus agrarius, to clarify the genetic diversity and phylogenetic relation ... | 2012 | 22607077 |
| seroprevalence of hantaviruses in small wild mammals trapped in south korea from 2005 to 2010. | the seroprevalence of hantaan virus (htnv) in wild rodents in south korea was analyzed. wild rodents were trapped in 18 cities in eight provinces during 2005-2007 and on three islands and four mountains during 2008-2010. sera were collected from 629 out of 933 trapped wild animals and examined for immunoglobulin g antibodies to htnv using indirect immunofluorescence assays. apodemus agrarius (80.1%) was the most frequently captured species at almost all trapping sites. the overall prevalence of ... | 2012 | 22548542 |
| interannual cycles of hantaan virus outbreaks at the human-animal interface in central china are controlled by temperature and rainfall. | hantavirus, a rodent-borne zoonotic pathogen, has a global distribution with 200,000 human infections diagnosed annually. in recent decades, repeated outbreaks of hantavirus infections have been reported in eurasia and america. these outbreaks have led to public concern and an interest in understanding the underlying biological mechanisms. here, we propose a climate-animal-hantaan virus (htnv) infection model to address this issue, using a unique dataset spanning a 54-y period (1960-2013). this ... | 2017 | 28696305 |
| hantavirus surveillance and genetic diversity targeting small mammals at camp humphreys, a us military installation and new expansion site, republic of korea. | small mammal surveillance was conducted (2008-2010, 2012) at camp (cp) humphreys, a us army installation and new expansion site, republic of korea (rok), to identify hemorrhagic fever with renal syndrome health threats to us military/civilian populations during its ongoing expansion phase. small mammals were collected using sherman live capture traps and transported to korea university where they were euthanized, tissues removed, and assayed to determine hantavirus igg antibody-positive and hant ... | 2017 | 28448595 |