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[human infection by lagochilascaris minor leiper, 1909. report of a case observed in the state of pará (brazil)]. 1978725430
experimental life cycle of lagochilascaris minor leiper, 1909.the life cycle of lagochilascaris minor was studied using material collected from human lesion and applying the experimental model: rodents (mice, hamsters), and carnivores (cats, dogs). in mice given infective eggs, orally, hatch of the third stage larvae was noted in the gut wall, with migration to liver, lungs, skeletal musculature and subcutaneous tissue becoming, soon after, encysted. in cats infected with skinned carcasses of mice (60 to 235 days of infection) it was observed: hatch of thi ...19921342084
[human lagochilascariasis. 3 cases encountered in the federal district, brazil].three new cases of human infection with lagochilascaris minor are reported. all the patients were from the state of pará (brazil), living in rural areas or close to the forest. they were admitted to hospitals in the federal district due to the presence of abscesses in the region of the neck, ear, mastoid process and, in two of them, to the involvement also of the central nervous system. microscopic examination of tissue samples taken from the lesions showed sections of eggs and worms--in differe ...19921342129
experimental heteroxenous cycle of lagochilascaris minor leiper, 1909 (nematoda: ascarididae) in white mice and in cats.reports of natural infections of sylvatic carnivores by adult worms of species similar to lagochilascaris minor in the neotropical region led to attempts to establish experimental cycles in laboratory mice and in cats. also, larval development was seen in the skeletal muscle of an agouti (dasyprocta leporina) infected per os with incubated eggs of the parasite obtained from a human case. in cats, adult worms develop and fertile eggs are expelled in the feces; in mice, larval stages of the parasi ...19921343667
[natural infection of speothos venaticus (carnivora: canidae) by adult stages of lagochilascaris sp].an adult male speothos venaticus lund (bush dog) was found killed on a rural road in the northeast of bolívar state, in a locality where a patient with lagochilascariasis has lived for the past 16 years. the animal was frozen for 1 month, and after removal of the head and skin, was autopsied. two adult gravid females of lagochilascaris sp. were found in the trachea. certain morphological characteristics of the soft parts differed from the description given for lagochilascaris minor leiper, 1909; ...19911844975
[infection induced in wild rodents dasyprocta leporina (rodentia: dasyproctidae), with larval eggs of lagochilascaris minor (nematoda: ascarididae)].specimens of dasyprocta leporina (linnaeus, 1758) were raised out their natural environment. at three to four months of age they were orally inoculated with lagochilascaris minor (leiper, 1909) eggs obtained from a native patient. the eggs were incubated for more than 80 days so that it was possible to obtain, by mechanical compression, larvae that could be maintained alive in liquid medium for 48 hours or more. the animals were sacrificed 14-46 days after infection and tangled larva in inflamma ...19902135484
[in vitro effect of ivermectin on the eggs of lagochilascaris minor leiper, 1909]. 19883241946
fatal encephalopathy due to lagochilascaris minor infection.a 14-year-old boy with a tetralogy of fallot showed a subacute, progressive encephalopathy characterized by headache, stupor and coma. death occurred three months after the beginning of the illness. neuropathologic examination revealed diffuse foci of necrosis of the cerebral hemispheres and cerebellum, and the presence of the nematode lagochilascaris minor in the parenchyma and in the cisterns at the base of the brain. in almost all 28 cases of human lagochilascaris previously reported, the wor ...19863706624
[lagochilascaris minor leiper, 1909 (nematoda-ascaridae) of human origin]. 19863797950
[fatal pulmonary infection caused by lagochilascaris sp., probably lagochilascaris minor leiper, 1909]. 19854035207
thiabendazole therapy of lagochilascaris minor infection in surinam. report of a case. 19715568126
lagochilascaris minor infection in surinam. report of a case. 19685672783
[a new case of human parasitism, by lagochilascaris minor leiper, 1909, observed in the state of são paulo, brasil]. 19685679032
[new cases of human infection by lagochilascaris minor leiper, 1909, found in the state of pará, brazil]. 19836684323
lagochilascaris minor infection in venezuela. report of a case.a lagochilascaris minor infection in a 6-year-old venezuelan girl with a 4-year history of nasal obstruction is reported. treatment with levamisole resulted in clinical and radiological cure. eggs of l. minor were observed in the patient's feces; these were cultured to second stage larvae.19826890772
human lagochilascariasis treated successfully with ivermectin: a case report.a 15 year old male patient was diagnosed as being infected with the nematode lagochilascaris minor, presenting as abscesses over the left mastoid region, and invading the temporal bone, mastoid sinuses and possibly the cns. surgical drainage and administration of cambendazole and levamisole led to improvement, followed by an early relapse and poor tolerance to the antihelminthic drugs. repeated doses of ivermectin (an animal preparation) were used for the first time to treat this condition and r ...19938115799
evaluation in white mice of the infectivity of eggs of lagochilascaris minor (nematoda: ascarididae), incubated by decortication with sodium hypochlorite (naocl).white mice were used to study the infectivity of the eggs of lagochilascaris minor leiper, 1909 after incubation in liquid media, with or without preservative substances. potassium bichromate (k2cr2o7) at 1% restrict hatching, while 1% formalin gave a greater larval yield. incubation of eggs in distilled water, in roux or falcon flasks gave a good yield, whether the eggs were obtained from human feces or from experimentally infected cats. treatment of eggs with sodium hypochlorite (naocl) at 5.2 ...19938284605
infection of the soft tissue of the neck due to lagochilascaris minor. 19938337728
first case of lagochilascaris minor infection in bolivia.few cases of human infection with lagochilascaris minor have been reported in the literature. they occurred in central and south america and the caribbean. we describe the first patient with this nematode infection in bolivia.19968980600
infestation from lagochilascaris minor in mexico.an 11-year-old girl presented from villa azueta, veracruz, a poor and small town on the tesechoacan riverside. the tesechoacan riverside is a tropical area in the south-east of mexico, between 18 degrees, 04',32" latitude and 95 degrees, 42',23" longitude. her family consisted of both parents and 12 brothers, all apparently healthy and living in a humble hut, with poor nutrition and hygiene. the main sign was a tumor on her neck that had developed during the previous 6 months. on clinical examin ...19979071620
scanning electron microscopy of lagochilascaris minor leiper, 1909 (nematoda: ascarididae).lagochilascaris minor leiper, 1909 is a parasitic nematode with its biological cycle still unknown, even though it was found in humans, domestic and silvatic animals. adult worms, collected by surgical drainage from a human patient from the state of pará, brazil, were micrographed using a scanning electron microscope. morphological aspects of males and females such as cephalic structures, caudal papillae and cuticular patterns were analyzed and compared with the previous descriptions adding new ...19989698865
assessment of ivermectin therapeutic efficacy on third-stage larvae of lagochilascaris minor in mice experimentally infected.in this study we evaluated the potential action of ivermectin on third-stage larvae, both at migratory and encysted phases, in mouse tissues after experimental infection with lagochilascaris minor. study groups i and ii consisted of 120 mice that were orally administered 1,000 parasite eggs. in order to assess ivermectin action upon migratory larvae, group i (60 mice) was equally split in three subgroups, namely i-a, i-b, and i-c. on the 7th day after inoculation (dai), each animal from the subg ...19989830726
lagochilascaris minor in a patient from the colombian amazon: a case report.a chronic infection (10 years) by lagochilascaris minor is described in a woman from the amazon region of colombia. this is the third case of infection by this parasite that has been described so far in colombia, and only the first one in a person coming from the colombian amazon region.199810436660
wild rodents as experimental intermediate hosts of lagochilascaris minor leiper, 1909.a total of 25 specimens of cavia porcellus (guinea pig), 5 dasyprocta agouti (agouti), and 22 calomys callosus (vesper mice) were inoculated with infective eggs of lagochilascaris minor. the inoculum was prepared with embryonated eggs and orally administered to each individual animal through an esophagus probe. in parallel, 100 specimens of felis catus domesticus were individually fed with 55-70 nodules containing 3rd-stage larvae encysted in tissues of infected rodents. animals were examined an ...199910445999
[a case report of human lagochilascariasis coming from pará state, brazil].a new case of lagochilascariasis is reported in a child from xinguara, pa, brazil. the patient had an abscess in the right cervical region, which was drained at the clinical hospital of ufg. eggs and adult stages of lagochilascaris minor were found in the secretion of the abscess. treatment with albendazol, at a dosage of 400 mg/day for 30 days, associated with antibiotics promoted regression of the lesion.200010881125
[assessment of ivermectin therapeutic efficacy on fourth-stage larvae of lagochilascaris minor in experimentally infected cats].in order to verify the action of ivermectin against fourth-stage larvae of lagochilascaris minor, thirty cats were divided into three groups (i, ii and iii). each animal was inoculated orally with 50 third-stage larvae. the cats from groups i and ii were treated with ivermectin (200/microg/kg/single dose/sc via) on fifth day after inoculation (dai). treatment evaluation was performed between 30 and 40 dai (group i) and between 180 to 190 dai (group ii) using parasite macroscopic and microscopic ...200111562732
subcutaneous infection of lagochilascaris minor in domestic cats from uruguay.the nematode lagochilascaris minor was collected from subcutaneous abscesses on the face and neck of three female cats aged 8 months, and 1 and 2 years. these cats were born in the department of maldonado, uruguay. female and male nematodes were 10.1-14.4 and 10.0-14.3mm long, respectively. the lips were one dorsal lip and two subventral lips separated from the body by a deep post-labial groove, and were separated from each other by triangular interlabial projections. the width of the lips was a ...200212208042
infestation with lagochilascaris minor (leiper) in man. 195613305481
notes on lagochilascaris minor leiper, 1909. 195713447818
experimental lagochilascariosis: histopathological study of inflammatory response to larval migration in the murine model.the goal of this study was to investigate the pattern of inflammatory response induced by lagochilascaris minor in murine experimental model. for this purpose 115 mice were given 1000-3000 l. minor infective eggs "per os" and 51 uninfected mice were considered as controls. four hours post-inoculation (pi), 3rd stage larvae were seen passing through the mucosa of terminal ends of small intestine. six hours pi larvae were observed as an embolus inside the portal vein and also migrating through the ...200415322629
lagochilascaris minor third-stage larvae secrete metalloproteases with specificity for fibrinogen and native collagen.dissemination of parasitic infections depends on migration through tissues and evasion from both hemostatic processes and immune responses from hosts. metalloproteases play major roles in these mechanisms of pathogen-host interactions and, thus, are considered drug targets. in this study, we characterized metalloprotease activities in excretory/secretory (es) products from third stage larvae (l3) of the ascarid lagochilascaris minor, the causative agent of lagochilascariosis, which demonstrates ...200616979366
lagochilascaris minor: experimental infection of c57bl/6 and balb/c isogenic mice reveals the presence of adult worms.the nematode lagochilascaris minor is the causative agent of lagochilascariosis, a human disease that affects the neck region causing exudative abscesses with eggs, larvae, and adult parasites. mice are currently considered intermediate hosts for the parasite. to determine the pattern of infection and the possibility of mice as definitive hosts for l. minor, experimental lagochilascariosis was studied in two distinct isogenic mouse strains: balb/c and c57bl/6. our results indicate that balb/c mi ...200818456261
[hematological, serum biochemical and serological profile of felis domesticus with experimental lagochilascariosis].the present study evaluated the hemogram, different proteins, plasma enzymes, serum enzymes and specific antibody production of felis domesticus experimentally infected by lagochilascaris minor. the infected animals were seen to present increased total leukocytes (particularly eosinophils), decreased platelet counts, increased aspartate-aminotransferase and alanine-aminotransferase and, especially, the presence of specific igg antibodies against antigens of the parasite. the reaction with crude ...200819009193
lagochilascaris minor: antibody production in experimentally infected mice.lagochilascaris minor is the causative agent of lagochilascariosis, a disease that affects the neck region and causes festering abscesses, with eggs, adult parasites and l3/l4 larvae within the purulent exudates. today, mice are considered to be intermediate hosts for the parasite. c57bl/6 mice produce immunoglobulin igm, iga and igg against the crude extract of the parasite; on the other hand, antibodies produced against the secreted/excreted antigens of lagochilascaris minor present lower leve ...200919684983
experimental lagochilascariosis in x-chromosome-linked immunodeficient mice.lagochilascaris minor is the etiological agent of lagochilascariosis, a disease that affects the neck region and causes exudative abscesses, with eggs, adult parasites and l3/l4 larvae in the purulent exudates. mice are now considered to be intermediate hosts for the parasite. to determine the pattern of infection in b1 cell-deficient mice, experimental lagochilascariosis was studied in balb/c and x-chromosome-linked immunodeficient (xid) mice. balb.xid-infected mice showed lower numbers of larv ...200919802472
otomastoidititis with right retroauricular fistula by lagochilascaris minor. 201020658027
lagochilascaris minor: susceptibility and resistance to experimental infection in mice is independent of h-2 haplotype and correlates with the immune response in immunized animals.recently, we demonstrated that c57bl/6 mice are more susceptible to experimental lagochilascariosis than balb/c mice. to investigate the pattern of infection and the role of the genetic background on susceptibility to infection, we studied experimental lagochilascariosis in h-2(a) identical b10.a and a/j mice. infected b10.a mice had a lower survival ratio and more severe lesions in the lungs than did a/j mice. splenocytes of a/j mice immunized with the crude extract of the parasite showed incre ...201020721343
infection with lagochilascaris minor. 196320789733
lagochilascaris minor (nematoda: ascarididae) from a wild cougar ( puma concolor ) in mexico.we document parasitation of a wild cougar ( puma concolor ) by the nematode lagochilascaris minor in hidalgo state, mexico. this finding contributes to our understanding of the epidemiology of this zoonotic agent in mexico.201627310170
evaluation of the therapeutic efficacy of levamisole hydrochloride on third-stage larvae of lagochilascaris minor in experimentally infected mice.lagochilascariosis, a disease caused by lagochilascaris minor, affects the neck, sinuses, tonsils, lungs, the sacral region, dental alveoli, eyeballs and the central nervous system of humans. a cycle of autoinfection may occur in human host tissues characterized by the presence of eggs, larvae and adult worms. this peculiarity of the cycle hinders therapy, since there are no drugs that exhibit ovicidal, larvicidal and vermicidal activity. given these facts, we studied the action of levamisole hy ...201627253745
lagochilascariasis in cats (felis catus domesticus) in southern brazil.lagochilascariasis, a parasitic disease little known in brazil, is caused by an ascarid nematode that has a peculiar life cycle, with a predilection site for the cervical region in the final hosts: humans, cats and dogs. we aimed to record the occurrence of lagochilascaris minor in domestic cats from rural areas in the municipality of pelotas, rio grande do sul state, brazil, with reports of clinical signs and the treatment applied.201424692048
analysis of spleen cells in susceptible and resistant mice with experimental lagochilascariosis.lagochilascariosis is an emerging parasitic disease caused by the helminth lagochilascaris minor. the experimental mouse model has been used to study the immune response against l. minor infection. in the present work, immunohistochemistry analysis of spleen cells populations was evaluated in susceptible (c57bl/6) and resistant (balb/c) mice experimentally infected with l. minor. the balb/c mice exhibited increased spleen cell indexes as follows: f4/80+ at 100 days after infection (dpi), cd4+ at ...201327335846
lagochilascaris minor leiper, 1909 (nematoda: ascarididae) in mexico: three clinical cases from the peninsula of yucatan.human lagochilascariasis (hl) is a parasite produced by lagochilascaris minor leiper 1909 that also can be found in cats and dogs. hl is considered an emerging zoonosis in the americas, spreading from mexico to argentina, and the caribbean islands. the present paper describes three hl cases from the peninsula of yucatan, mexico, recorded in the last decade. it describes the characteristics of the lesions and discusses the route of transmission in humans and particularly in the observed patients.201223152314
human lagochilascariasis-a rare helminthic disease.lagochilascariasis is a parasitic disease caused by a helminth of the order ascaroidea, genus lagochilascaris that comprises 6 species, among which only lagochilascaris minor leiper, 1909, is implicated in the human form of the disease. it is remarkable that the majority of cases of human lagochilascariasis in the americas have been reported in brazil. the natural definitive hosts of this parasite seem to be wild felines and canines. lagochilascariasis is mostly a chronic human disease that can ...201728640884
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