Publications

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[studies of immobilization of treponema carateum with blood sera and csf]. 195413225083
[effect in vitro of synnematin b and penicillin on treponema carateum immobilization]. 195513281122
[influence of sweat on the detection of treponema carateum]. 196114477234
[antibodies against treponema carateum of pinta in the blood serum of pinta patients]. 195015438400
the experimental transmission of pinta, mal del pinto or carate to the rabbit.in this preliminary note we describe the results obtained by inoculation of the skin of the scrotum of four black rabbits with serous fluid expressed from an initial pinta lesion. the inoculation was made intradermally, as superficially as possible, with serous fluid rich in treponemata and diluted with normal salt solution. a papule appeared at the point of inoculation in one of the four rabbits on the 105th day. one hundred and fifteen days after inoculation the papule presented a circular ero ...194517830538
the protection of pancreatic lipase by acacia gum.in this preliminary note we describe the results obtained by inoculation of the skin of the scrotum of four black rabbits with serous fluid expressed from an initial pinta lesion. the inoculation was made intradermally, as superficially as possible, with serous fluid rich in treponemata and diluted with normal salt solution. a papule appeared at the point of inoculation in one of the four rabbits on the 105th day. one hundred and fifteen days after inoculation the papule presented a circular ero ...194517830539
[not available]. 194720251894
Genetic diversity in Treponema pallidum: Implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws.Pathogenic uncultivable treponemes, similar to syphilis-causing Treponema pallidum subspecies pallidum, include T. pallidum ssp. pertenue, T. pallidum ssp. endemicum and Treponema carateum, which cause yaws, bejel and pinta, respectively. Genetic analyses of these pathogens revealed striking similarity among these bacteria and also a high degree of similarity to the rabbit pathogen, Treponema paraluiscuniculi, a treponeme not infectious to humans. Genome comparisons between pallidum and non-pall ...201122198325
the endemic treponematoses.the agents of human treponematoses include four closely related members of the genus treponema: three subspecies of treponema pallidum plus treponema carateum. t. pallidum subsp. pallidum causes venereal syphilis, while t. pallidum subsp. pertenue, t. pallidum subsp. endemicum, and t. carateum are the agents of the endemic treponematoses yaws, bejel (or endemic syphilis), and pinta, respectively. all human treponematoses share remarkable similarities in pathogenesis and clinical manifestations, ...201424396138
pinta: latin america's forgotten disease?pinta is a neglected, chronic skin disease that was first described in the sixteenth century in mexico. the world health organization lists 15 countries in latin america where pinta was previously endemic. however, the current prevalence of pinta is unknown due to the lack of surveillance data. the etiological agent of pinta, treponema carateum, cannot be distinguished morphologically or serologically from the not-yet-cultivable treponema pallidum subspecies that cause venereal syphilis, yaws, a ...201526304920
serodiagnosis of syphilis by enzyme-linked immunosorbent assay with purified recombinant treponema pallidum antigen 4d.an enzyme-linked immunosorbent assay (elisa) for syphilis has been developed that detects igg antibody to purified recombinant treponema pallidum surface antigen 4d. the 4d elisa was capable of detecting 25 ng of 4d antigen-specific antibody. neither 172 nonsyphilitic sera nor 20 false-positive sera in the venereal disease research laboratory test reacted in the 4d elisa. the sensitivity of the 4d elisa was comparable to that of the adsorbed fluorescent treponemal antibody test in primary, secon ...19863517186
specificity of antibodies from patients with pinta for antigens of treponema pallidum subspecies pallidum.inhabitants of a remote panamanian village were examined for clinical and serological evidence of pinta infection. of 104 persons examined, 21 (20%) had clinical evidence of active or inactive pinta, and 54 (52%) were seropositive. sera were evaluated for antibody to individual treponema pallidum antigens. sera from all four patients with active pinta contained antibody to the 47-48 kilodalton major antigen; the intensity of reactivity and the number of antigens recognized increased with age and ...19883275725
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