| genomics of end-pleistocene population replacement in a small mammal. | current species distributions at high latitudes are the product of expansion from glacial refugia into previously uninhabitable areas at the end of the last glaciation. the traditional view of postglacial colonization is that southern populations expanded their ranges into unoccupied northern territories. recent findings on mitochondrial dna (mtdna) of british small mammals have challenged this simple colonization scenario by demonstrating a more complex genetic turnover in britain during the pl ... | 2018 | 29436497 |
| copper influence on bank vole's (myodes glareolus) sexual behavior. | the impact of human activity on the environment has led to a steady increase of the amounts of copper in the ecosystems. this element accumulates in plants and water, potentially exposing rodents to its harmful effects. in industrial districts, a decrease in the density of small rodent populations has been observed. this decline may be caused by many factors, including mortality, decreased fertility, or impaired sexual behavior. the decline in the reproductive abilities of small rodents after co ... | 2018 | 29396672 |
| recombinant prpsc shares structural features with brain-derived prpsc: insights from limited proteolysis. | very solid evidence suggests that the core of full length prpsc is a 4-rung β-solenoid, and that individual prpsc subunits stack to form amyloid fibers. we recently used limited proteolysis to map the β-strands and connecting loops that make up the prpsc solenoid. using high resolution sds-page followed by epitope analysis, and mass spectrometry, we identified positions ~116/118, 133-134, 141, 152-153, 162, 169 and 179 (murine numbering) as proteinase k (pk) cleavage sites in prpsc. such sites l ... | 2018 | 29385212 |
| parasite community dynamics in an invasive vole - from focal introduction to wave front. | multiple parasite species simultaneously infecting a host can interact with one another, which has the potential to influence host-parasite interactions. invasive species typically lose members of their parasite community during the invasion process. not only do the founding population escape their parasites, but the rapid range expansion of invaders once in the invaded range can lead to additional stochastic loss of parasites. as such, parasite community dynamics may change along an invasion gr ... | 2017 | 30951575 |
| a dopamine and noradrenaline reuptake inhibitor (bupropion) does not alter exercise performance of bank voles. | physical performance is determined both by biophysical and physiological limitations and behavioral characteristic, specifically motivation. we applied an experimental evolution approach combined with pharmacological manipulation to test the hypothesis that evolution of increased aerobic exercise performance can be triggered by evolution of motivation to undertake physical activity. we used a unique model system: bank voles from a lines, selected for high swim-induced aerobic metabolism (vo2swim ... | 2016 | 29491918 |
| experimental sars-cov-2 infection of bank voles. | after experimental inoculation, severe acute respiratory syndrome coronavirus 2 infection was confirmed in bank voles by seroconversion within 8 days and detection of viral rna in nasal tissue for up to 21 days. however, transmission to contact animals was not detected. thus, bank voles are unlikely to establish effective transmission cycles in nature. | 2021 | 33754987 |
| geographical distribution and genetic diversity of bank vole hepaciviruses in europe. | the development of new diagnostic methods resulted in the discovery of novel hepaciviruses in wild populations of the bank vole (myodes glareolus, syn. clethrionomys glareolus). the naturally infected voles demonstrate signs of hepatitis similar to those induced by hepatitis c virus (hcv) in humans. the aim of the present research was to investigate the geographical distribution of bank vole-associated hepaciviruses (bvhvs) and their genetic diversity in europe. real-time reverse transcription p ... | 2021 | 34203238 |
| disappearance of tbev circulation among rodents in a natural focus in alsace, eastern france. | tick-borne encephalitis virus (tbev) depends mainly on a fragile mode of transmission, the co-feeding between infected nymphs and larvae on rodents, and thus persists under a limited set of biotic and abiotic conditions. if these conditions change, natural tbev foci might be unstable over time. we conducted a longitudinal study over seven years in a mountain forest in alsace, eastern france, located at the western border of known tbev distribution. the objectives were (i) to monitor the persiste ... | 2020 | 33182764 |
| the european bison (bison bonasus) as an indicatory species for the circulation of tick-borne encephalitis virus (tbev) in natural foci in poland. | tick-borne encephalitis (tbe) is one of the most common zoonotic diseases in europe transmitted by ixodidae vectors. while small mammals such as bank voles and ticks constitute the main reservoirs for virus transmission, large sylvatic species act as a food source for ticks. cervids such as roe deer and red deer are considered sentinel species for tbe in natural foci. in addition, an increase of the population size and density of large wild mammals in an area corresponds to an increase in the ti ... | 2021 | 34358779 |
| long-term presence of tick-borne encephalitis virus in experimentally infected bank voles (myodes glareolus). | tick-borne encephalitis virus (tbev) is a vector-borne pathogen that can cause serious neurological symptoms in humans. across large parts of eurasia tbev is found in three traditional subtypes: the european, the siberian and the far-eastern subtype. small mammalian animals play an important role in the transmission cycle as they enable the spread of tbev among the vector tick population. to assess the impact of tbev infection on its natural hosts, outbred bank voles (myodes glareolus) were inoc ... | 2021 | 33690089 |
| hantavirus-leptospira coinfections in small mammals from central germany. | european orthohantaviruses (puumala orthohantavirus (puuv); dobrava-belgrade orthohantavirus (dobv), genotype kurkino; tula orthohantavirus (tulv)), and leptospira spp. are small mammal-associated zoonotic pathogens that cause diseases with potentially similar symptoms in humans. we investigated the frequency of leptospira spp. and hantavirus single and double infections in small mammals from 22 sites in thuringia, central germany, during 2017. tulv infections were detected at 18 of 22 sites (me ... | 2021 | 33612134 |
| rodent host population dynamics drive zoonotic lyme borreliosis and orthohantavirus infections in humans in northern europe. | zoonotic diseases, caused by pathogens transmitted between other vertebrate animals and humans, pose a major risk to human health. rodents are important reservoir hosts for many zoonotic pathogens, and rodent population dynamics affect the infection dynamics of rodent-borne diseases, such as diseases caused by hantaviruses. however, the role of rodent population dynamics in determining the infection dynamics of rodent-associated tick-borne diseases, such as lyme borreliosis (lb), caused by borre ... | 2021 | 34373474 |
| impact of landscape on host-parasite genetic diversity and distribution using the puumala orthohantavirus-bank vole system. | in nature, host specificity has a strong impact on the parasite's distribution, prevalence, and genetic diversity. the host's population dynamics is expected to shape the distribution of host-specific parasites. in turn, the parasite's genetic structure is predicted to mirror that of the host. here, we study the tandem puumala orthohantavirus (puuv)-bank vole system. the genetic diversity of 310 bank voles and 33 puuv isolates from 10 characterized localities of northeast france was assessed. ou ... | 2021 | 34361952 |
| climate change accelerates winter transmission of a zoonotic pathogen. | many zoonotic diseases are weather sensitive, raising concern how their distribution and outbreaks will be affected by climate change. at northern high latitudes, the effect of global warming on especially winter conditions is strong. by using long term monitoring data (1980-1986 and 2003-2013) from northern europe on temperature, precipitation, an endemic zoonotic pathogen (puumala orthohantavirus, puuv) and its reservoir host (the bank vole, myodes glareolus), we show that early winters have b ... | 2021 | 34228253 |
| genetic diversity of puumala orthohantavirus in rodents and human patients in austria, 2012-2019. | puumala orthohantavirus (puuv) has a wide distribution throughout europe. distinctive temporal patterns of spillover into the human population are related to population dynamics of the reservoir host, the bank vole (clethrionomys glareolus). as the rodent host is tied to specific habitats with small individual ranges, puuv genetic diversity is also highly correlated with geographic distance. using sequenced portions of viral s and m segments, we determined whether geographic clusters were suppor ... | 2021 | 33918083 |
| isolation and genetic characterization of puumala orthohantavirus strains from france. | puumala orthohantavirus (puuv) causes a mild form of haemorrhagic fever with renal syndrome (hfrs) called nephropathia epidemica (ne), regularly diagnosed in europe. france represents the western frontier of the expansion of ne in europe with two distinct areas: an endemic area (north-eastern france) where puuv circulates in rodent populations, with the detection of many human ne cases, and a non-endemic area (south-western france) where the virus is not detected, with only a few human cases bei ... | 2021 | 33809526 |
| evolutionary relationships of ljungan virus variants circulating in multi-host systems across europe. | the picornavirus named 'ljungan virus' (lv, species parechovirus b) has been detected in a dozen small mammal species from across europe, but detailed information on its genetic diversity and host specificity is lacking. here, we analyze the evolutionary relationships of lv variants circulating in free-living mammal populations by comparing the phylogenetics of the vp1 region (encoding the capsid protein and associated with lv serotype) and the 3dpol region (encoding the rna polymerase) from 24 ... | 2021 | 34372523 |
| neutralizing ljungan virus antibodies in children with newly diagnosed type 1 diabetes. | ljungan virus (lv), a parechovirus of the picornavirus family, first isolated from a bank vole at the ljungan river in sweden, has been implicated in the risk for autoimmune type 1 diabetes. an assay for neutralizing ljungan virus antibodies (nlva) was developed using the original 87-012 lv isolate. the goal was to determine nlva titres in incident 0-18 years old newly diagnosed type 1 diabetes patients (n=67) and school children controls (n=292) from jämtland county in sweden. nlva were found i ... | 2021 | 34020728 |
| hamster polyomavirus research: past, present, and future. | hamster polyomavirus (mesocricetus auratus polyomavirus 1, hapyv) was discovered as one of the first rodent polyomaviruses at the end of the 1960s in a colony of syrian hamsters (mesocricetus auratus) affected by skin tumors. natural hapyv infections have been recorded in syrian hamster colonies due to the occurrence of skin tumors and lymphomas. hapyv infections of syrian hamsters represent an important and pioneering tumor model. experimental infections of syrian hamsters of different colonies ... | 2021 | 34068409 |