Publications

[pharmacology of arnica montana l].		1949	15406032
[arnica montana].		1952	12983199
[arnica (arnica montana)].		1953	13073403
[arnica montana. iii].		1953	13073437
[arnica; arnica montana. ii].		1953	13073424
[arnica montana mistaken for inula britannica].		1954	13177151
[possible testing of tinctures of arnica montana l..].		1954	13198192
[study on the constituents of arnica montana l].		1956	13328059
[arnica montana as a medicinal plant].		1959	13834712
[arnica montana as a medicinal plant].		1959	13676103
[some new constituents from the roots of arnica montana].		1963	13987185
[therapeutic experiences with arnica montana].		1965	14263823
[contribution to the knowledge of the substances contained in arnica montana l].		1966	5926222
[cultivation experiments with arnica species. ii. vegetative propagation of arnica montana l].		1967	5603484
[arnica montana l].		1968	5681721
[a still mysterious medicinal plant, arnica montana l].		1971	4927860
[fatty acids of the essential oil from leaves of arnica montana and arnica longifolia].		1972	4403598
[identification of carotenoids in arnica montana].		1973	4732114
[new components of blossoms from arnica montana l].		1974	4134079
identification of the allergens of arnica montana l.		1978	154377
helenalinmethacrylate, a new pseudoguaianolide from the flowers of arnica montana l. and the sensitizing capacity of their sesquiterpene lactones.		1978	704699
the sensitizing capacity of compositae plants. i. occupational contact dermatitis from arnica longifolia eaton.	three patients with occupational contact dermatitis due to arnica longifolia eaton and arnica montana l. are reported. during cultivation, harvesting of the flower heads, chemical investigation of the sesquiterpene lactone constituents and preparation of therapeutic tinctures, they had frequent contact with the plant materials. patch tests with the two sesquiterpene lactones carabron and helenalin, isolated during investigation from a. longifolia eaton, were positive in all three patients, thoug ...	1978	148995
[arnica allergy].	arnica montana l. (plant family: compositae) is one of the oldest and most important drug plants. besides its healing effects it also reveals sensitizing properties. from the literature more than 35 references with more than 100 cases of contact dermatitis could be cited, completed by four own cases. in most cases sensitization was induced by self treatment with tincture of arnica, whereas occupational contact dermatitis in drug sellers of pharmacists is rare. chemical and animal experimental in ...	1980	6993423
[efficacy of the phenol compounds of arnica in toxic lesion of the liver].	experiments on rats with toxic liver injury induced by carbon tetrachloride have shown that the preparation presenting a sum of phenolic compounds of arnica montana and foliated arnica favours a more complete recovery of the bile secretion intensity, synthesis and excretion with bile of bile acids and bilirubin, and cholesterol excretion. it also accelerates the recovery of activity of serum enzymes.	1983	6852212
[helenalin- and 11,13-dihydrohelenalinester from flowers of arnica montana.].	from the flowers of arnica montana l. 13 helenanolides were isolated and identified. they are shown to be 11,13-dihydrohelenalin ( 1), helenalin ( 2) and their ester derivatives 3-13 (see figure). the natural occurence of 6-o-isobutyryl-, 6-o-tigloyl-, 6-o-isovaleryl- and 6-o-(2-methyl)-butyrylhelenalin (compounds 9, 11, 12, 13) is reported for the first time. the qualitative sesquiterpene lactone composition in flowers of a. montana from different regions was found to be variable.	1983	17405058
[immunostimulant action of polysaccharides (heteroglycans) from higher plants. preliminary communication].	from the water or alcaline-water extracts of echinacea purpurea (l.) moench and -angustifolia dc., eupatorium cannabinum l. and -perfoliatum l., chamomilla recutita (l.) (rauscher), calendula officinalis l., baptisia tinctoria (l.) r.b., achyrocline satureoides dc., arnica montana l., sabal serrulata roem et schult. and eleutherococcus senticosus maxim. polysaccharide fractions with molecular weights in the range of 25 000 to 500 000 and higher have been isolated, which, according to the granulo ...	1984	6541484
methylated flavonoids from arnica montana and arnica chamissonis.	from the flowers of arnica chamissonis less, subsp. foliosa var. incana, the methylated flavonoids acacetin, pectolinarigenin, hispidulin, jaceosidin, 6-methoxykaempferol, and betuletol have been isolated and identified by spectroscopic methods. except for acacetin, the same flavonoids were identified in the flowers of arnica montana l. betuletol was found for the first time in the family of asteraceae.	1984	17340267
6-o-isobutyryl-tetrahydrohelenalin from the flowers of arnica montana.	from the flowers of arnica montana l., the helenanolides 6- o-isobutyryl-tetrahydrohelenalin and 2beta-ethoxy-6- o-isobutyryl-2,3-dihydrohelenalin were isolated and their structures established by spectroscopic methods.	1984	17340245
metronidazole (flagyl) and arnica montana in the prevention of post-surgical complications, a comparative placebo controlled clinical trial.	a double blind trial, was designed, in which 118 patients undergoing the removal of impacted wisdom teeth were randomly divided into the following groups; 41 patients received metronidazole, 39 patients received arnica montana, 38 patients received the placebo. metronidazole was more effective in pain control than arnica (p less than 0.001) and placebo (p less than 0.01). it prevented swelling better than arnica (p less than 0.01) and placebo (p less than 0.05) and was more effective in promotin ...	1984	6365158
[immunostimulating action of polysaccharides (heteroglycans) from higher plants].	from the water or alcaline-water extracts of echinacea purpurea (l.) moench. and -angustifolia dc., eupatorium cannabium l. and -perfoliatum l., chamomilla recutita l. rauscher, calendula officinalis l., baptisia tinctoria (l.) r. b., achyrocline satureioides dc., arnica montana l., sabal serrulata roem. et schult., and eleutherococcus (acanthopanax) senticosus maxim. polysaccharide fractions with molecular weights in the range of 25 000 to 500 000 and higher have been isolated, which, according ...	1985	4052142
characterization of arnica montana l. flowers.		1987	3455222
flavonoid glycosides from arnica montana and arnica chamissonis.	five flavonoid glycosides were identified from flowers of arnica montana, four from a. chamissonis subsp. foliosa var. incana. the structures were established on the basis of total acid hydrolysis and spectral data (uv, (1)h-nmr, (13)c-nmr, ms) as hispidulin 7- o-beta-glucoside, isorhamnetin 3- o-beta-glucoside, 3- o-beta- d-glucopyranosides of spinacetin, 6-methoxykaempferol and patuletin and querectin 3- o-(6''- o-acetyl)-beta- d-glucopyranoside. the latter compound can serve as distinctive ma ...	1987	17269063
flavonoid glucuronides from the flowers of arnica montana1.	five flavonoid glucuronides were identified from flowers of arnica montana l. the structures were established on the basis of total acid hydrolysis and spectral data (uv, (1)h-nmr, (13)c-nmr, mass) as 3- o-beta- d-glucuronides of quercetin, kaempferol, isorhamnetin, patuletin, and 6-methoxykaempferol. the last one is a new natural compound. this is the first report on glucuronides in the genus arnica. additionally, tricin and 3,5,7-trihydroxy-6,3',4'-trimethoxyflavone were identified. up to now ...	1988	17265264
helenalin and 11 alpha,13-dihydrohelenalin, two constituents from arnica montana l., inhibit human platelet function via thiol-dependent pathways.	this study investigates the effect on human platelet function of two sesquiterpene lactones from arnica montana l., helenalin (h) and 11 alpha,13-dihydrohelenalin (dh). both compounds inhibited collagen-induced platelet aggregation, thromboxane formation and 5-hydroxytryptamine secretion in a concentration-dependent manner at 3-300 microm. when arachidonic acid was used as stimulus, thromboxane formation remained unaffected despite of inhibition of platelet aggregation. both h and dh reduced the ...	1990	2116680
postpartum homeopathic arnica montana: a potency-finding pilot study.		1990	2102159
[immunologic studies of plant combination preparations. in-vitro and in-vivo studies on the stimulation of phagocytosis].	the activity of phagocytosis was tested in the in vitro granulocyte test and the in vivo carbon-clearance-test in the mouse for an extract combination consisting of four plant extracts (echinacea angustifolia, eupatorium perfoliatum, baptisia tinctoria and arnica montana). in both immune models, a step by step stimulation of the activity of phagocytosis by the addition of the four plant extracts was shown with an increase in effectiveness of partially over 50% in comparison to the pure echinacea ...	1991	1799388
[effect of arnica d 30 during hard physical exertion. a double-blind randomized trial during the oslo marathon 1990].	the effect of arnica montana on stiffness, restitution time and cell damage during hard physical exercise was evaluated in a randomized double blind trial during the oslo marathon. 36 participants were randomized: one group received arnica 10(-30) five pills twice daily for five days, starting the day before the event. the other group received placebo pills. blood tests were carried out before and immediately after finish, and after 48 and 72 hours. stiffness was evaluated on a visual analogue s ...	1991	1780819
immunologically active polysaccharides of arnica montana cell cultures.	from the nutrition medium of arnica montana cell cultures two homogeneous polysaccharides, an acidic arabino-3,6-galactan-protein with mean mr of 100,000 and a neutral fucogalactoxyloglucan with mean mr of 22,500 have been isolated by deae-sepharose cl-6b and sephacryl s-400 column chromatography. their structures were elucidated mainly by methylation analysis, partial acidic and enzymatic hydrolysis and 13c nmr spectroscopy. the fucogalactoxyloglucan shows a pronounced enhancement of phagocytos ...	1991	1367382
new flavonoid glycosides from arnicae flos dab 91.	five flavonoid glycosides were identified from flowers of arnica montana, ten from a. chamissonis subsp. foliosa var. incana. the structures were established on the basis of acid hydrolysis and spectral data (uv, nmr, ms) as the 7-beta-glucosides of pectolinarigenin, apigenin, and chrysoeriol; luteolin 3'- o-beta-glucoside; the 3-beta-glucuronides of kaempferol, isorhamnetin, and 6-methoxykaempferol; the 3,7-di-beta-glucosides of quercetin and patuletin; the 3-beta-glucosides of betuletol and qu ...	1992	17226484
shoot tip culture of arnica montana for micropropagation.	multiple shoots were regenerated from shoot tips of arnica montana on ms and b5 media supplemented with ba (1 mg/l) and naa (0.1 mg/l). sections of 1-2 mm in length cultured from in vitro germinated seedlings regenerated 7.7 (mean) shoots on the ms medium, whereas sections cultured from greenhouse plants regenerated 9.0 (mean) shoots on the b5 medium within 6 weeks. subsequent subcultures of shoots on the same media but without naa resulted in similar or lower multiplication rates (1.6 to 3.1 in ...	1992	17226438
tussilagine and isotussilagine: two pyrrolizidine alkaloids in the genus arnica1.	in flowerheads of arnica montana, a. chamissonis ssp. foliosa, a. amplexicaulis, and a. sachalinensis, traces of the non-toxic pyrrolizidine alkaloids tussilagine and isotussilagine were detected. their identity was unambiguously confirmed by direct comparison (tlc, gc, gc/ms) with the authentic samples.	1992	17226521
[the effects of arnica montana on blood coagulation. randomized controlled trial].	the purpose of this study, which took the form of a two-period cross-over clinical trial, was to determine whether a homeopathic substance, arnica montana, significantly decreased bleeding time (simplate ii) and to describe its impact on various blood coagulation tests. it was not shown that this substance had a significant impact on various parameters of blood coagulation in healthy volunteers in the period immediately following administration [corrected].	1993	7903572
helenalin acetate in in vitro propagated plants of arnica montana.	propagated "in vitro" shoots and plantlets of arnica montana l. (asteraceae) have been shown to produce sesquiterpene lactones, i.e. helenalin and 11,13-dihydrohelenalin esters. the compounds were detected in green organs only; roots of the plantlets contained no sesquiterpene lactones. the helenalin acetate content in leaves of the plantlets (0.073% dry wt) was 4-times higher than in proliferated shoots (0.016% dry wt). the best rate of shoot multiplication was achieved on ms medium, supplement ...	1993	17230337
mekc as an improved method to detect falsifications in the flowers of arnica montana and a. chamissonis.	arnica montana and arnica chamissonis ssp. foliosa flowers are often adultered by blending them with those from heterotheca inuloides. tlc, hplc, and tsp lc/ms have been proposed to detect this kind of falsification. a new method based on micellar electrokinetic chromatography (mekc) has been developed. this procedure permits us to characterize rapidly each drug and to detect easily falsifications from h. inuloides in arnica drugs.	1994	17236057
helenalin, an anti-inflammatory sesquiterpene lactone from arnica, selectively inhibits transcription factor nf-kappab.	alcoholic extracts prepared form arnicae flos, the collective name for flowerheads from arnica montana and a. chamissonis ssp. foliosa, are used therapeutically as anti-inflammatory remedies. the active ingredients mediating the pharmacological effect are mainly sesquiterpene lactones, such as helenalin, 11alpha,13-dihydrohelenalin, chamissonolid and their ester derivatives. while these compounds affect various cellular processes, current data do not fully explain how sesquiterpene lactones exer ...	1997	9348104
efficacy of homeopathic arnica: a systematic review of placebo-controlled clinical trials.	the efficacy of homeopathic remedies has remained controversial. the homeopathic remedy most frequently studied in placebo-controlled clinical trials is arnica montana.	1998	9820349
sesquiterpene lactone content in leaves of in vitro and field cultivated arnica montana.	on the basis of gc and gc/ms analyses we report on the full qualitative and quantitative sesquiterpene lactone (stl) content of in vitro cultivated a. montana plantlets consisting of helenalin and 11alpha,13-dihydrohelenalin esters in approximately equal amounts. the accumulation of stl was shown to be correlated with tissue differentiation in the above-ground parts. the seasonal variation of stl content in leaves of a. montana cultivated in the proving field was investigated. changes in the com ...	1998	17253241
[effect of arnica montana tincture on some hydrolytic enzyme activities of rat liver in experimental toxic hepatitis].	effects of tinctura arnica on arginase, adenosine triphosphatase, glucose-6-phosphatase and 5'-nucleotidase activities of rats liver in case of experimental toxic hepatitis have been studied. toxic hepatitis was caused by 2 times interstomach administration of 0.25 ml oil solution of carbon tetrachloride per 100 g of animal weight. 20 mkl/100 g of tinctura arnica was administered every day per os for 14 days. the enzyme activities have been investigated at 3, 7 and 17 days. a significant dementi ...	1998	10402655
[effect of arnica montana on the state of lipid peroxidation and protective glutathione system of rat liver in experimental toxic hepatitis].	effects of tinctura arnica on lipids peroxidation and on the protective glutathions system of liver in rats in case of experimental toxic hepatitis have been studied. toxic hepatitis is accompanied by deep alterations of the oxidant-antioxidant status of the body. intoxication of the body by ccl4 results in intensification of the free radicals formation particularly in liver: accumulation of lipids peroxidation molecular products, glutathione system enzyme activity inhibition in early terms and ...	1998	9848164
contact dermatitis caused by sesquiterpene lactones.	compositae dermatitis involves workers such as gardeners, florists, and farmers, and less commonly people not employed in occupations at risk.	1998	9471988
effect of traumeel s, a homeopathic formulation, on blood-induced inflammation in rats.	to evaluate the activity of traumeel s (trs), a homeopathic formulation containing arnica montana and other plant extracts and minerals on an animal model of traumatic inflammation.	1999	10709306
in vitro antimicrobial activity of propolis and arnica montana against oral pathogens.	arnica and propolis have been used for thousands of years in folk medicine for several purposes. they possess several biological activities such as anti-inflammatory, antifungal, antiviral and tissue regenerative, among others. although the antibacterial activity of propolis has already been demonstrated, very few studies have been done on bacteria of clinical relevance in dentistry. also, the antimicrobial activity of arnica has not been extensively investigated. therefore the aim here was to e ...	2000	10716618
final report on the safety assessment of arnica montana extract and arnica montana.	arnica montana extract is an extract of dried flowerheads of the plant, arnica montana. arnica montana is a generic term used to describe a plant material derived from the dried flowers, roots, or rhizomes of a. montana. common names for a. montana include leopard's bane, mountain tobacco, mountain snuff, and wolf's bane. two techniques for preparing arnica montana extract are hydroalcoholic maceration and gentle disintegration in soybean oil. propylene glycol and butylene glycol extractions wer ...	2001	11558636
the seamy side of natural medicines: contact sensitization to arnica (arnica montana l.) and marigold (calendula officinalis l.).	medical remedies of plant origin have gained increasing popularity in recent years. both anaphylactic and eczematous allergic reactions are on the rise, accordingly. arnica and marigold, both of the compositae family, are in widespread use, but only limited data are available on their allergenic potential. we tested 443 consecutive patients, in addition to the european standard and other series, with compositae mix, sesquiterpene lactone mix, arnica, marigold, and propolis. 5 subjects ( approxim ...	2001	11722485
potential for danger with arnica montana.		2001	11293536
mycorrhizal plants of traditionally managed boreal grasslands in norway.	this paper reports on the mycorrhizal status of 82 plant species growing in traditionally managed grasslands in three different locations in the boreal and boreo-nemoral vegetation zone in the eastern part of norway. seventy-four species were found to have arbuscular mycorrhiza (am). to our knowledge, we report am for the first time in achillea ptarmica, ajuga pyramidalis, alchemilla glaucescens, carex brunnescens, carex pallescens, crepis praemorsa, hieracium lactucella, rumex longifolius, scor ...	2002	12072981
studies on the anti-inflammatory activity of phytopharmaceuticals prepared from arnica flowers.	phytopharmaceuticals prepared from flowerheads of arnica montana of spanish origin and of the new type "arbo", which can be easily and economically cultivated, were studied for their capability to impair activation of the transcription factors nf-kappa b and nf-at. both proteins are responsible for the transcription of genes encoding various inflammatory mediators. additionally, their influence on the release of the cytokines il-1 and tnf-alpha were examined. the inhibitory activities correlate ...	2002	12058311
contact sensitization from compositae-containing herbal remedies and cosmetics.	the compositae (asteraceae) family of plants is currently an important cause of allergic plant contact dermatitis in europe. the family comprises some of the oldest and most valued medicinal plants, and the increasing popularity of herbal medicine and cosmetics may theoretically result in a growing number of compositae sensitizations from these sources. according to the literature at least 15 species, including among others arnica (arnica montana), german and roman chamomile (chamomilla recutita ...	2002	12492516
nonlinear effects of glutamate and kcl on glutamate toxicity in cultured rat cerebellar neurons.	nonlinear responses to toxin exposure have been observed in multiple cell types and organisms across a wide array of phyla. high dose toxin exposures inhibit or kill biological systems, while low dose exposures can stimulate survival mechanisms. we examined the effects of low (10(-3), 10(-5), 10(-7), and 10(-9) m) and ultra-low (10(-25) and 10(-61) m) kcl and glutamate pretreatment (72 h) against glutamate toxicity in rat cerebellar neurons. ultra-low dilutions (10(-31), 10(-61), and 10(-401)) o ...	2003	12856478
antibacterial activity of medicinal plant extracts against periodontopathic bacteria.	this study was performed to evaluate the antibacterial activity of althaea officinalis l. roots, arnica montana l. flowers, calendula officinalis l. flowers, hamamelis virginiana l. leaves, illicium verum hook. fruits and melissa officinalis l. leaves, against anaerobic and facultative aerobic periodontal bacteria: porphyromonas gingivalis, prevotella spp., fusobacterium nucleatum, capnocytophaga gingivalis, veilonella parvula, eikenella corrodens, peptostreptococcus micros and actinomyces odont ...	2003	12820224
dermatitis from arnica montana.		2003	145351
homeopathic treatment in emergency medicine: a case series.	following a multiple-casualty construction disaster in israel, members of the center of integrated complementary medicine joined in the emergency activity of the shaare zedek medical center. they administered homeopathic treatment to injured patients to supplement conventional orthopaedic treatment. this was to our knowledge the first time that complementary medicine had been used officially in conjunction with conventional medicine in an emergency situation. our objective is to report and summa ...	2003	12587994
arnica montana and homeopathic dosing guidelines.		2003	12900640
arnica montana and dosing of homeopathic medication.		2004	15220606
sesquiterpene lactones in arnica montana: a rapid analytical method and the effects of flower maturity and simulated mechanical harvesting on quality and yield.	a rapid extraction, clean-up and rplc procedure suitable for routine quantitative analyses of sesquiterpene lactones (sls) in arnica montana is described. seven sls were isolated of which tigloyl and methacryloyl esters of helenalin made up over 50 % of the total. this method was applied to analyses of replicated samples of different flower parts, different stages of flower maturity, and herb from different harvest methods. the mean total sl levels were higher in the disk flowers (0.872 % w/w) t ...	2004	14994196
skin penetration studies of arnica preparations and of their sesquiterpene lactones.	alcoholic preparations of arnica montana are widely used for the topical treatment of various inflammatory diseases. sesquiterpene lactones (sls) are mainly responsible for their anti-inflammatory activity. here we have studied the penetration kinetics of arnica tinctures prepared from dried arnica flowers originating from different chemotypes as well as of their respective dominating sls, helenalin isobutyrate and 11alpha,13-dihydrohelenalin acetate. some alcoholic preparations of fresh arnica ...	2004	15490315
anti-inflammatory activity of arnica montana 6ch: preclinical study in animals.	the anti-inflammatory effect of arnica montana 6ch was evaluated using acute and chronic inflammation models. in the acute, model, carrageenin-induced rat paw oedema, the group treated with arnica montana 6ch showed 30% inhibition compared to control (p < 0.05). treatment with arnica 6ch, 30 min prior to carrageenin, did not produce any inhibition of the inflammatory process. in the chronic model, nystatin-induced oedema, the group treated 3 days previously with arnica montana 6ch had reduced in ...	2004	15139092
in vitro behaviour of sesquiterpene lactones and sesquiterpene lactone-containing plant preparations in human blood, plasma and human serum albumin solutions.	the interactions of the three sesquiterpene lactones (sls) dihydrohelenalin acetate, dihydrohelenalin methacrylate and helenalin isobutyrate from arnica montana and of parthenolide from tanacetum parthenium as well as of three ethanolic arnica preparations with human blood proteins using different matrices, human serum albumin (hsa), plasma and whole blood, were investigated. the extent of protein binding in human plasma or to human albumin differed significantly between individual sls (dihydroh ...	2004	15114499
dual inhibition of 5-lipoxygenase/cyclooxygenase by a reconstituted homeopathic remedy; possible explanation for clinical efficacy and favourable gastrointestinal tolerability.	in order to elucidate potential anti-inflammatory activities of zeel comp. n and its constituents, the inhibition of the synthesis of leukotriene b4 (ltb4) and prostaglandin (pge2) by 5-lipoxygenase (5-lox) and cyclo-oxygenase 1 and 2 (cox 1 and 2) respectively were examined in vitro.	2004	15060721
[arnica montana in facial injuries (proceedings)].		2004	855982
new sesquiterpene lactones from arnica tincture prepared from fresh flowerheads of arnica montana.	investigation of an ethanolic extract prepared from fresh arnica montana flowers afforded three new 1,5- trans-guaianolides, of which 11alpha,13-dihydro-2-o-tigloylflorilenalin and the respective 2-o-isovaleryl derivative are reported for the first time. additionally, three new and one known 2beta-ethoxy-2,3-dihydrohelenalin esters were isolated. gc/ms studies of the extract after a two year storage at 4 degrees c demonstrated that the latter were artefacts that had been formed by addition of et ...	2005	16320207
single-family versus multi-family introductions.	the early success of plant introduction as a function of source material and habitat quality was tested in arnica montana to determine whether different introduction strategies could affect plant viability of the introduced population. plants originating from related (single-family introductions) and unrelated (multi-family introductions) individuals were introduced into undisturbed sites and into sites which were limed, turf cut, or both turf cut and limed. for four consecutive years, we analys ...	2005	16163616
the effect of the homeopathic remedies arnica montana and bellis perennis on mild postpartum bleeding--a randomized, double-blind, placebo-controlled study--preliminary results.	to evaluate the effect of arnica montana and bellis perennis on postpartum blood loss.	2005	16036165
[on the effectiveness of the homeopathic remedy arnica montana].	arnica montana is a homeopathic remedy often prescribed after traumata and injuries.	2005	16425108
development and stability of semisolid preparations based on a supercritical co2 arnica extract.	conventional herbal drug preparations (hdp) based on arnica montana l. have a low content of the active principles, sesquiterpene lactones, which show poor stability and low physical compatibility in semisolid formulations. recently, an innovative supercritical carbon dioxide (co2) extract with high sesquiterpene content has been marketed. development of six semisolid preparations (cetomacrogol, polysorbate 60, polawax, anphyphil, natrosol and sepigel) based on this innovative co2 extract is dis ...	2006	16457981
altitudinal variation of secondary metabolite profiles in flowering heads of arnica montana cv. arbo.	the altitudinal variation on the contents of secondary metabolites in flowering heads of arnica montana was assessed. plants of a. montana cultivar arbo were grown in nine experimental plots at altitudes between 590 and 2230m at mount patscherkofel near innsbruck/austria. the total contents of sesquiterpene lactones and flavonoids were not positively correlated with the altitude of the growing site. however, the proportion of flavonoids with vicinal free hydroxy groups in ring b to flavonoids la ...	2006	16405933
homeopathic arnica therapy in patients receiving knee surgery: results of three randomised double-blind trials.	we investigated the effectiveness of homeopathic arnica montana on postoperative swelling and pain after arthroscopy (art), artificial knee joint implantation (akj), and cruciate ligament reconstruction (clr).	2006	17105693
[cholagogue action of arnica montana].		2006	14391392
thymol derivatives from hairy roots of arnica montana.	five known thymol derivatives were isolated from roots of arnica montana transformed with agrobacterium rhizogenes lba 9402. the compounds were characterized by spectral methods. the pattern of thymol derivatives in light-grown hairy roots was slightly different from that in dark-grown ones. this is the first report on the presence of thymol derivatives in hairy roots of the plant.	2006	16586074
permeation of bioactive constituents from arnica montana preparations through human skin in-vitro.	this study investigated and characterised transdermal permeation of bioactive agents from a topically applied arnica montana tincture. permeation experiments conducted over 48 h used polydimethylsiloxane (silastic) and human epidermal membranes mounted in franz-type diffusion cells with a methanol-water (50:50 v/v) receptor fluid. a commercially available tincture of a. montana l. derived from dried spanish flower heads was a donor solution. further donor solutions prepared from this stock tinct ...	2006	16945174
arnica montana gel in osteoarthritis of the knee: an open, multicenter clinical trial.	this open multicenter trial investigated the safety and efficacy of an arnica montana fresh plant gel, applied twice daily, in 26 men and 53 women with mild to moderate osteoarthritis (oa) of the knee. after 3 and 6 weeks, significant decreases in median total scores on the western ontario and mcmaster universities osteoarthritis index (womac) were evident in the intention-to-treat and per-protocol populations (both p < .0001). scores on the pain, stiffness, and function subscales also showed si ...	2006	12539881
rat models of acute inflammation: a randomized controlled study on the effects of homeopathic remedies.	one of the cardinal principles of homeopathy is the "law of similarities", according to which patients can be treated by administering substances which, when tested in healthy subjects, cause symptoms that are similar to those presented by the patients themselves. over the last few years, there has been an increase in the number of pre-clinical (in vitro and animal) studies aimed at evaluating the pharmacological activity or efficacy of some homeopathic remedies under potentially reproducible co ...	2007	17233886
skin penetration behaviour of sesquiterpene lactones from different arnica preparations using a validated gc-msd method.	preparations of arnica montana l. are widely used for the topical treatment of inflammatory diseases. the anti-inflammatory activity is mainly attributed to their sesquiterpene lactones (sls) from the helenalin and 11alpha,13-dihydrohelenalin type. to study the penetration kinetics of sls in arnica preparations, a stripping method with adhesive tape and pig skin as a model was used. for the determination of sls in the stripped layers of the stratum corneum (sc), a gas chromatography/mass spectro ...	2007	16930911
effect of vehicles on topical application of aloe vera and arnica montana components.	in this study two types of gels and microemulsions are investigated for their ability to dissolve, release, and induce the permeation of helenalin, a flavonoid responsible for the anti-inflammatory activity of arnica montana extract, and aloin, an anthrone-c-glucosyls with antibacterial activity present in aloe vera extract. the release of these agents from each vehicle was followed by hplc, and transcutaneous permeation was examined using a modified franz cell and a porcine skin membrane. the s ...	2007	17994359
retrospective analysis of 736 implants inserted without antibiotic therapy.	the routine use of antibiotics in oral implant treatment seems to be widespread. the principle of antibiotic prophylaxis before oral surgical procedures in patients at risk for endocarditis or in those who are severely immunocompromised is well established. antibiotic therapy in conjunction with implant surgery in fit patients and its correlation with failure and success rates remains poorly documented, however. the debate regarding overprescription of antibiotics raises the need for a critical ...	2007	17954332
homeopathic arnica montana for post-tonsillectomy analgesia: a randomised placebo control trial.	to evaluate the efficacy of homeopathic arnica in reducing the morbidity following tonsillectomy.	2007	17227743
a novel melanin inhibitor: hydroperoxy traxastane-type triterpene from flowers of arnica montana.	we isolated a novel inhibitor of melanin biosynthesis from the flowers of arnica montana l. (compositae), and identified it as a traxastane-type triterpene (3beta,16beta-dihydroxy-21alpha-hydroperoxy-20(30)-taraxastene) [1] by means of 1d or 2d-nmr and liquid chromatography/high-resolution mass spectrometry (lc-hr-ms). compound [1] at the concentration of 0.53 mum completely inhibited melanin accumulation in cultured b16 melanoma cells. it is one of the most potent among known plant inhibitors o ...	2007	17473428
altitudinal variation of secondary metabolite profiles in flowering heads of matricaria chamomilla cv. bona.	the altitudinal variation of the contents of secondary metabolites in flowering heads of matricaria chamomilla l. (asteraceae) was assessed. plants of m. chamomilla cultivar bona were grown in nine experimental plots at altitudes between 590 and 2,230 m at mount patscherkofel near innsbruck/austria. the amounts of flavonoids and phenolic acids were quantified by hplc/dad. for both flavonoids and phenolic acids positive (r = 0.559 and 0.587) and statistically significant (both p < 0.001) correlat ...	2008	18484542
quantitative analysis of flavonoids and phenolic acids in arnica montana l. by micellar electrokinetic capillary chromatography.	arnica montana preparations have been used in europe for centuries to treat skin disorders. among the biologically active ingredients in the flower heads of the plant are sequiterpenes, flavonoids and phenolic acids. for the simultaneous determination of compounds belonging to the latter two groups a micellar electrokinetic capillary chromatography (mekc) method was developed and validated. by using an electrolyte solution containing 50 mm borax, 25 mm sodium dodecyl sulfate and 30% of acetonitr ...	2008	18420051
cosmetics and herbal remedies with compositae plant extracts - are they tolerated by compositae-allergic patients?	compositae-sensitive patients are routinely warned against topical use of compositae-containing cosmetics and herbal remedies. however, the risk of elicitation of dermatitis in presensitized persons is unknown.	2008	18154553
altitudinal variation of phenolic contents in flowering heads of arnica montana cv. arbo: a 3-year comparison.	in continuation of our studies of altitudinal effects on secondary metabolite profile of flowering heads from taxa of the asteraceae, we investigated phenolic contents and radical scavenging potential from cultivated plants of arnica montana cv. arbo during the growing seasons 2003, 2004, and 2005. by conducting experiments on potted plants, we excluded that differences in phenolic contents from plants grown at different altitudes were related primarily to differences in soil composition at thes ...	2008	18259818
effect of homeopathy on analgesic intake following knee ligament reconstruction: a phase iii monocentre randomized placebo controlled study.	the efficacy of homeopathy is still under debate and a recent meta-analysis recommended further randomized double-blind clinical trials to identify any clinical situation in which homeopathy might be effective.	2008	18251757
reduced nitrogen has a greater effect than oxidised nitrogen on dry heathland vegetation.	we investigated the effects of different ratios of reduced (nh4+) versus oxidised (no3(-)) nitrogen in deposition on heathland and species-rich grassland vegetation at high nitrogen deposition levels in large mesocosms filled with nutrient-poor soils to which different nh4+/no3(-) ratios were applied. the response of the forbs, antennaria dioica, arnica montana, gentiana pneumonanthe, thymus serpyllum, the grasses danthonia decumbens, deschampsia flexuosa, nardus stricta and the shrub calluna vu ...	2008	18206283
anti-inflammatory and immune-regulatory mechanisms prevent contact hypersensitivity to arnica montana l.	sesquiterpene lactones (sl), secondary plant metabolites from flowerheads of arnica, exert anti-inflammatory effects mainly by preventing nuclear factor (nf)-kappab activation because of alkylation of the p65 subunit. despite its known immunosuppressive action, arnica has been classified as a plant with strong potency to induce allergic contact dermatitis. here we examined the dual role of sl as anti-inflammatory compounds and contact allergens in vitro and in vivo. we tested the anti-inflammato ...	2008	18341569
identification of hydroxycinnamoylquinic acids of arnica flowers and burdock roots using a standardized lc-dad-esi/ms profiling method.	a screening method using lc-dad-esi/ms was developed for the identification of common hydroxycinnamoylquinic acids based on direct comparison with standards. a complete standard set for mono-, di-, and tricaffeoylquinic isomers was assembled from commercially available standards, positively identified compounds in common plants (artichokes, asparagus, coffee bean, honeysuckle flowers, sweet potato, and vernonia amygdalina leaves) and chemically modified standards. four c18 reversed phase columns ...	2008	18837557
contact allergy to compositae plants in patients with atopic dermatitis.	to investigate the frequency of compositae sensitivity is one of the most important goals of current dermatology and allergology. we have patch tested 30 adult patients suffering from "extrinsic" atopic dermatitis with sesquiterpene lactone mix and compositae mix including compositae mix individual ingredients, extracts of arnica (arnica montana), chamomile (chamomilla recutita), tansy (tanacetum vulgare), fever few (tanacetum parthenium) and yarrow (achillea millefolium) as well as with specifi ...	2009	15503788
helenalin suppresses essential immune functions of activated cd4+ t cells by multiple mechanisms.	helenalin is a naturally occuring sesquiterpene lactone extracted from arnica montana and arnica chamissonis ssp. foliosa. helenalin and its derivatives are known for anti-cancer and anti-inflammatory effects via inhibiting nf-kappab and telomerase activity and impairing protein and dna synthesis, suggesting that helenalin is a potential candidate for the treatment of deregulated and unwanted t cell-mediated immune responses. here we show that helenalin induces apoptosis in activated cd4+ t cell ...	2009	19656571
effects of phonophoresis with arnica montana onto acute inflammatory process in rat skeletal muscles: an experimental study.	this study aimed at verifying the effects of phonophoresis associated with arnica montana on the acute phase of an inflammatory muscle lesion. forty wistar male rats (300+/-50 g), of which the tibialis anterior muscle was surgically lesioned, were divided into four groups (n=10 each): control group received no treatment; the ultrasound group (us) was treated in pulsed mode with 1-mhz frequency, 0.5 w/cm(2) intensity (spatial and temporal average - sata), duty cycle of 1:2 (2 ms on, 4 ms off, 50% ...	2009	19152953
[cultivation of arnica montana].		2009	13051137
temperature is the key to altitudinal variation of phenolics in arnica montana l. cv. arbo.	plants in alpine habitats are exposed to many environmental stresses, in particular temperature and radiation extremes. recent field experiments on arnica montana l. cv. arbo indicated pronounced altitudinal variation in plant phenolics. ortho-diphenolics increased with altitude compared to other phenolic compounds, resulting in an increase in antioxidative capacity of the tissues involved. factors causing these variations were investigated by climate chamber (cc) experiments focusing on tempera ...	2009	19194724