Publications

massive elimination of multinucleated osteoclasts by eupatilin is due to dual inhibition of transcription and cytoskeletal rearrangement.	osteoporosis is an aging-associated disease requiring better therapeutic modality. eupatilin is a major flavonoid from artemisia plants such as artemisia princeps and artemisia argyi which has been reported to possess various beneficial biological effects including anti-inflammation, anti-tumor, anti-cancer, anti-allergy, and anti-oxidation activity. complete blockade of rank-dependent osteoclastogenesis was accomplished upon stimulation prior to the receptor activator of nuclear factor κb (rank ...	2015	28377971
fermented rice bran prevents atopic dermatitis in dncb-treated nc/nga mice.	the fermentation of natural plants has a favorable effect on the functional and biological activities of living systems. these include anti-oxidative, anti-inflammatory, and anti-platelet aggregation activities. this is attributed to the chemical conversion of the parent plants to functional constituents, which show more potent biological activity. in our study, rice bran along with oriental medicinal plants (angelicae gigantis, cnidium officinale, artemisia princeps, and camellia sinensis) was ...	2016	27323667
allohumibacter endophyticus gen. nov., sp. nov., isolated from the root of wild artemisia princeps (mugwort).	a novel actinobacterium designated strain mwe-a11t was isolated from the root of wild artemisia princeps (mugwort). the isolate was aerobic, gram-stain-positive and short rod-shaped, and the colonies were yellow and circular with entire margin. strain mwe-a11t grew at 15-37 °c and ph 6.0-8.0. the predominant isoprenoid quinones were mk-11 and mk-10. the predominant fatty acids were anteiso-c15:0 and iso-c16:0, and the dna g+c content was 68.8 mol%. the main polar lipids were diphosphatidylglycer ...	2016	26842896
effects of artemisia princeps supplementation on bone metabolism in ovariectomized rats.	the aim of this study was to investigate the effects of artemisia princeps (ap) extract on bone metabolism and its potential role in the prevention of osteoporosis in ovariectomized rats. twenty-six female sprague-dawley rats were divided into five groups and treated as follows: sham-operated control group (sham); ovariectomized control group (ovx), ovariectomized group treated by gavage with 10 mg/kg/day alendronate (alen); ovariectomized group treated by gavage with 100 mg/kg/day artemisia pri ...	2016	27102792
eupafolin enhances trail-mediated apoptosis through cathepsin s-induced down-regulation of mcl-1 expression and ampk-mediated bim up-regulation in renal carcinoma caki cells.	eupafolin, a flavone found in artemisia princeps, has been reported for its anti-tumor activity in several cancer cells. in this study, we examined whether eupafolin could sensitize trail-mediated apoptosis in human renal carcinoma caki cells. we found that eupafolin alone and trail alone had no effect on apoptosis. however, combined treatment with eupafolin and trail markedly induced apoptosis in human renal carcinoma (caki) cells, glioma cells (u251mg), and prostate cancer cells (du145), but n ...	2016	27582546
unexpected irregular monoterpene "yomogi alcohol" in the volatiles of the lathyrus l. species (leguminosae) of cyprus.	lathyrus species including l. ochrus and l. sativus are known for their food, feed and horticultural uses. despite their widespread uses and cultivation, there is limited information on their chemistry. previously, only the essential oil composition of l. rotundifolius, l. vernus and volatiles of l. odoratus have been reported. in the present research, volatiles of seven lathyrus l. species, namely, l. aphaca, l. ochrus, l. cicera, l. sativus, l. gorgonei, l. saxatilis and l. blepharicarpos var. ...	2016	26876676
the anti-inflammatory effects and mechanisms of eupafolin in lipopolysaccharide-induced inflammatory responses in raw264.7 macrophages.	eupafolin is a flavone isolated from artemisia princeps pampanini (family asteraceae). the aim of this study was to examine the anti-inflammatory effects of eupafolin in lipopolysaccharide (lps)-treated raw264.7 macrophages and lps-induced mouse skin and lung inflammation models and to identify the mechanism underlying these effects. eupafolin decreased the lps-induced release of inflammatory mediators (inos, cox-2 and no) and proinflammatory cytokines (il-6 and tnf-α) from the raw264.7 macropha ...	2016	27414646
the combination of artemisia princeps pamp, leonurus japonicas houtt, and gardenia jasminoides ellis fruit attenuates the exacerbation of energy, lipid, and glucose by increasing hepatic pgc-1α expression in estrogen-deficient rats.	artemisia princeps pamp (app), leonurus japonicas houtt (ljh), and gardenia jasminoides ellis fruit (gje) have been traditionally used in east asia to treat women's diseases related to reproductive system. they may attenuate the deterioration of energy, lipid, glucose and bone metabolism by estrogen deficiency. the present study explored the combination of app, ljh, and gje to overcome the symptoms of estrogen deficiency and the mechanism was explored.	2016	27216600
volatile components of the essential oil of artemisia montana and their sedative effects.	the sedative effects of volatile components in the essential oil of artemisia montana ("yomogi") were investigated and measured using gas chromatography-mass spectrometry (gc-ms). major components identified included 1,8-cineol, camphor, borneol, α-piperitone, and caryophyllene oxide. among them, 1,8-cineol exhibited the highest flavor dilution (fd) value in an aroma extract dilution analysis (aeda), followed by borneol, o-cymene, β-thujone, and bornyl acetate. the sedative effects of yomogi oil ...	2017	28381767