Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| serologic study of phocine distemper in a population of harbor seals in scotland. | a serologic survey of the prevalence of morbillivirus antibodies was conducted in a population of harbor seals (phoca vitulina) from northeastern scotland, where mortality was comparatively low during the 1988 phocine distemper virus outbreak. none of the 12 seals sampled before the epizootic were seropositive. thirty-five (52%) of 68 seals sampled after the beginning of the epizootic were seropositive, although there were significant age-related differences in both the number of seropositive in ... | 1992 | 1548798 |
| reinfection of lambs with bovine respiratory syncytial virus. | eight lambs which were experimentally infected with bovine respiratory syncytial virus (rsv) when they were six to eight weeks old were challenged with the same virus seven months later. after reinfection, lambs developed mild clinical disease and the virus was isolated from nasal swabs from three lambs and peripheral blood from two lambs. reinfection resulted in changes in peripheral blood cell populations. there was an early increase in the number of cd8+ t lymphocytes and b (lca p220+) lympho ... | 1992 | 1553439 |
| respiratory syncytial virus infection of alveolar macrophages in adult transplant patients. | pulmonary epithelial cells are thought to be the primary cellular targets for infection by respiratory syncytial virus (rsv) in vivo. to determine whether other pulmonary cells are infected by rsv, bronchoalveolar lavage cells from six adult transplant patients, four of whom had acute rsv infection, were examined by in situ immunohistochemistry to identify infected lung cells. both alveolar macrophages and epithelial cells were infected with rsv in vivo. at the single-cell level, three-color imm ... | 1992 | 1554223 |
| pathologic and immunocytochemical studies of morbillivirus infection in striped dolphins (stenella coeruleoalba). | hundreds of striped dolphins (stenella coeruleoalba) died along the spanish mediterranean coast during the second half of 1990. we necropsied 58 dolphins. partial collapse of the lungs with patchy atelectasis, subcutaneous edema, icterus, and stomatitis were the most prominent gross morphologic changes. histologically, a bronchiolo-interstitial pneumonia was the most frequent lesion (72% of the animals). it was characterized by hyperplasia of alveolar epithelial type ii cells and formation of mu ... | 1992 | 1557861 |
| morbillivirus threat to mediterranean monk seals? | 1992 | 1557882 | |
| the efficacy of nebulized metaproterenol in wheezing infants and young children. | the benefit of beta-adrenergic agonists in the treatment of acutely wheezing infants and young children has not been well documented in the outpatient setting. to determine the efficacy of nebulized metaproterenol sulfate, 74 children aged 36 months or younger with acute wheezing participated in a double-masked, randomized, placebo-controlled clinical trial. children received nebulized metaproterenol, either as an initial treatment or after a control treatment with normal saline solution. at bas ... | 1992 | 1558072 |
| epidemic of bronchiolitis in infants. | 1992 | 1559099 | |
| mucosal t cell distribution during infection with respiratory syncytial virus. | groups of 12-week-old balb/c mice were inoculated intranasally with respiratory syncytial virus (rsv) and sacrificed at regular intervals after infection. t lymphocyte subset distribution was determined in lung tissue, bronchoalveolar lavage (bal), peripheral blood, and spleen by means of flow cytometry employing monoclonal antibodies against the t cell membrane antigens thy1.2 (pan-t), ly2 (cd8), and l3t4 (cd4). thy1.2+ cells increased in the lung from 35.4% of total lymphocytes before infectio ... | 1992 | 1564449 |
| respiratory syncytial virus: a pediatric nursing plan of care. | thirty-three pediatric cases of respiratory syncytial viral (rsv) infections were treated at providence hospital's pediatric intensive care unit (picu), anchorage, ak, between september 1987 and march 1988. our 8-bed picu nursing and respiratory therapy staff learned effective techniques in caring for patients with rsv. our aim in this article is to share our approach in providing comprehensive care for patients with rsv infections. | 1992 | 1569520 |
| lower respiratory tract infection in hospitalized children due to respiratory syncytial (rs) virus during a suspected epidemic period of rs virus in delhi. | a study of 131 children below 5 years of age seeking hospitalization due to lower respiratory tract infections (lrti), comprising 56 cases of bronchiolitis, 61 cases of bronchopneumonia, and 14 cases of other lower respiratory tract diseases showed significant occurrence of bronchiolitis in younger age groups (chi 2 = 79.21; p less than 0.001). employing two rapid techniques, viz. immunofluorescent antibody technique (ifat) and enzyme immunoassay (eia) along with tissue culture, respiratory sync ... | 1992 | 1569638 |
| respiratory syncytial virus infection reinforces reflex apnea in young lambs. | to evaluate the effect of respiratory syncytial virus (rsv) infection on reflex apnea elicited by application of water on the laryngeal mucosa, 11 healthy, term lambs were chronically instrumented at 2 wk of age. six lambs were inoculated with bovine rsv, and five lambs were mock-infected. the lambs were studied awake and unsedated before and 4, 8, 14, and 21 d after infection. rsv infection was associated with slight rhinorrhea and with moderately increased tracheal mucous discharge. there was ... | 1992 | 1570205 |
| severe respiratory syncytial virus pneumonia after autologous bone marrow transplantation: a report of three cases and review. | three patients with acute leukemia who underwent autologous bone marrow transplantation (bmt) in complete remission, developed a severe respiratory syncytial virus (rsv) pneumonia, which was fatal in two. identification of rsv was made on the products of bronchoalveolar lavage by direct immunofluorescence. as already described by others, the initial course of rsv infection varies, depending on whether it occurs sooner or later after bmt with a better prognosis in the latter situation. treatment ... | 1992 | 1571714 |
| distinguishing between respiratory syncytial virus subgroups by protein profile analysis. | we subgrouped 75 strains of respiratory syncytial virus by a protein profile method (ppm) which relies on different mobilities of the phosphoprotein in one-dimensional polyacrylamide gel electrophoresis and does not require monoclonal antibodies. when compared with enzyme immunoassay, ppm correctly subgrouped 54 of 56 subgroup a and all 19 subgroup b strains. | 1992 | 1572961 |
| humoral immunity to respiratory syncytial virus infection in the elderly. | the relationship between serum immunoglobulins and the severity and risk of respiratory syncytial virus (rsv) infection in the institutionalized elderly was prospectively assessed during the winter of 1989-1990 at a 591 bed nursing home. forty rsv infections were identified out of 149 respiratory illnesses by isolation of the virus or by a greater than or equal to 4-fold rise in rsv-specific igg by eia. acute serum rsv igg levels were similar in those with rsv infection and those with non-rsv il ... | 1992 | 1573388 |
| an outbreak of respiratory syncytial virus in a bone marrow transplant center. | an outbreak of respiratory syncytial virus (rsv) infection occurred among 31 patients in a marrow transplant center over a 13-week period beginning in january 1990. rsv infection was also documented in 35 family members and employees. of 18 patients with pneumonia, 14 (78%) died. none of 13 with upper respiratory infection died. preengraftment patients tended to develop pneumonia more frequently than did engrafted patients. early administration of ribavirin may have had a beneficial effect in pa ... | 1992 | 1583345 |
| vaccination against acute respiratory virus infections and measles in man. | several viruses may cause more or less severe acute respiratory infections in man, some of which are followed by systemic infection. only for influenza and measles are licensed vaccines available at present. the protection induced by influenza vaccines, which are based on inactivated whole virus or viral subunits, depends largely on the matching of vaccine strain and circulating virus. measles vaccines, which are based on attenuated live virus, have been quite effective in controlling the diseas ... | 1992 | 1587542 |
| epidemiology of acute lower respiratory tract infections, especially those due to haemophilus influenzae type b, in the gambia, west africa. | mortality surveys undertaken in rural areas of the gambia, a small country on the west coast of africa, indicate that acute lower respiratory tract infections (alri) are the most frequent cause of death among children and that approximately 1 in 25 rural gambian children dies from an alri before the age of 5 years. community surveys suggest that each child experiences an average of one episode of alri accompanied by radiographic changes before reaching this age. etiologic studies have shown that ... | 1992 | 1588169 |
| pulmonary eosinophilic response to respiratory syncytial virus infection in mice sensitized to the major surface glycoprotein g. | to investigate the contribution of immunity to individual respiratory syncytial (rs) virus proteins to the augmentation of pulmonary pathology, mice were scarified with recombinant vaccinia viruses (rvv) expressing individual rs virus proteins. the pulmonary response to infection with rs virus was monitored by bronchoalveolar lavage (bal). in mice vaccinated with the major surface glycoprotein (g), 14-25% of bal cells were eosinophils; these comprised less than 3% of bal cells from other groups ... | 1992 | 1591217 |
| effect of respiratory syncytial virus on adherence, colonization and immunity of non-typable haemophilus influenzae: implications for otitis media. | adherence of non-typable haemophilus influenzae to respiratory epithelium was evaluated in a cotton rat model of respiratory syncytial virus (rsv) infection. colonization with non-typable h. influenzae increased to a maximum within 4 days of rsv infection compared to rsv negative controls (4.58 +/- 0.17 vs 3.82 +/- 0.23 log colony forming units (cfu) per ml, p less than 0.05) and then declined over the subsequent 10 days (2.0 +/- 0 vs 3.78 +/- 0.39 cfu per ml, p less than 0.0001). in a second se ... | 1992 | 1592548 |
| effect of "in vitro" exposure of bovine alveolar macrophages to different strains of bovine respiratory syncytial virus. | a vaccine strain of respiratory syncytial (rs) virus and an isolate from pneumonic calves (ac2) were inoculated onto cultures of bovine alveolar macrophages recovered by lung lavage, and the functional properties of the cells observed over a period of 10 days. in most cultures no infectious virus was produced although immunofluorescence indicated the presence of virus antigens in some cells. no significant difference was noted between infected and control macrophage cultures in their capacity to ... | 1992 | 1595187 |
| pneumonia in childhood: etiology and response to antimicrobial therapy. | a prospective eight-month study was carried out in 50 children admitted to hospital for radiologically confirmed community-acquired pneumonia. a potential causative agent of infection was identified in 44 (88%) cases. using virus isolation, virus antigen detection and enzyme immunoassay serology, respiratory virus infection was diagnosed in 30 (60%) patients. antibody assays for seven bacteria and antigen detection from serum and urine for streptococcus pneumoniae produced evidence of bacterial ... | 1992 | 1597197 |
| approaches to immunization against respiratory syncytial virus. | 1992 | 1600380 | |
| successful therapy with ribavirin of late onset respiratory syncytial virus pneumonitis complicating allogeneic bone transplantation. | a 21-year-old patient developed interstitial pneumonitis nine months post bone marrow transplant for acute myeloblastic leukaemia. immunofluorescence of broncheoalveolar lavage fluid revealed the presence of respiratory syncytial virus (rsv). aerosolized ribavarin therapy resulted in rapid resolution of the pneumonitis with full recovery without any side effects. ribavarin therapy should be considered early in the management of bmt patients who develop rsv pneumonitis. | 1992 | 1600691 |
| respiratory syncytial virus infection in an adult with wegener's granulomatosis. | respiratory syncytial virus (rsv) has been documented as a pathogen in adults who are immunocompromised because of various underlying conditions. to our knowledge, this is the first report of a patient with wegener's granulomatosis (wg) and rsv infection resulting in a fatal outcome. | 1992 | 1600799 |
| serious respiratory tract disease caused by respiratory syncytial virus: prospects for improved therapy and effective immunization. | 1992 | 1603639 | |
| summertime respiratory syncytial virus infection: epidemiology and clinical manifestations. | respiratory syncytial virus (rsv) is a common serious pathogen known to produce annual winter epidemics in young children. a 2-year study of children with significant respiratory disease during the summer revealed a 21% incidence of rsv infection. respiratory secretions collected from ill children in the lsumc outpatient clinics, from children seen by private physicians, and from children hospitalized with respiratory tract disease were assayed for rsv antigens. approximately 39% of those survey ... | 1992 | 1604385 |
| [epidemiology of respiratory syncytial virus infections in the canary islands]. | respiratory syncytial virus (rsv) is the major cause of lower respiratory tract infection in young children. outbreaks of rsv infection occur yearly during the winter or spring in temperate climates. our study of 634 hospitalized children under 3 years of age with bronchiolitis and pneumonia (november 1988 to january 1990) revealed that 227 (35.8%) had vrs infections. these cases showed a yearly epidemic pattern with 86.8% of the cases occurring during the winter. furthermore, 67.4% of the cases ... | 1992 | 1605415 |
| cotton rats previously immunized with a chimeric rsv fg glycoprotein develop enhanced pulmonary pathology when infected with rsv, a phenomenon not encountered following immunization with vaccinia--rsv recombinants or rsv. | in studies conducted in the 1960s, children previously immunized with a formalin-inactivated respiratory syncytial virus (rsv) vaccine (fi-rsv) developed a greater incidence and severity of pulmonary disease during subsequent natural rsv infection than did controls. it was previously shown that cotton rats immunized with fi-rsv or immunoaffinity-purified fusion (f) glycoprotein developed enhanced pulmonary histopathology following intranasal challenge with rsv. in the present studies, various fo ... | 1992 | 1609551 |
| etiology of paget's disease of bone: a new perspective. | 1992 | 1617506 | |
| recent observations regarding the pathogenesis of recurrent respiratory syncytial virus infections: implications for vaccine development. | respiratory syncytial virus (rsv) and influenza virus are common pathogens for all age groups. currently licensed influenza virus vaccines generally provide protection from clinically detectable disease caused by antigenically matched challenging viruses. in contrast, vaccine development for rsv has been hampered by the inability of candidate vaccines to induce protective immunity to naturally occurring infection. the precise mechanism(s) responsible for the rsv vaccine failures have not been de ... | 1992 | 1621415 |
| [induction of il2 responsiveness in allergen-stimulated lymphocytes from children with post respiratory syncytial virus (rsv) infection]. | induced interleukin 2 (il2) responsiveness in allergen-stimulated lymphocytes from children with post respiratory syncytial virus (rsv) infection was studied. induction of il2 responsiveness in the patients lymphocytes was observed upon stimulation with allergens such as dermatophgoides farinae (df) antigen, ovalbumin (ova) and alpha-casein. such responses were not induced in age-matched normal lymphocytes. maximum response was shown in lymphocytes from children who had been suffering from the i ... | 1992 | 1622335 |
| immunoglobulin g antibody avidity in patients with respiratory syncytial virus infection. | the titer and avidity of respiratory syncytial virus-specific antibodies were measured in 196 serum specimens from 93 children with an acute, laboratory-confirmed respiratory syncytial virus infection. an enzyme immunoassay method based on the ability of urea to dissociate the bound antibodies with low avidity from the antigen was used. three patterns of immune responses were observed. children less than 6 months of age usually had low titers of antibodies with high avidity in their acute-phase ... | 1992 | 1624567 |
| oesophageal foreign body: an unusual cause of respiratory symptoms in a three-week-old baby. | impaction of a foreign body in the oesophagus is common in children. if the event is not witnessed by an adult or the object is radiolucent the diagnosis is difficult as respiratory symptoms may predominate. we report a three-week-old child with respiratory symptoms who had both a respiratory syncytial virus infection and a radio-lucent oesophageal foreign body. this case is the youngest yet reported and serves as a remainder of the difficulties in the diagnosis of this important condition. | 1992 | 1624897 |
| testing of bronchoalveolar lavage for the laboratory diagnosis of respiratory syncytial virus infections. | 1992 | 1625081 | |
| testing of bronchoalveolar lavage for the laboratory diagnosis of respiratory syncytial virus infections. | 1992 | 1625082 | |
| [the future of viral pathology]. | 1992 | 1636998 | |
| antibodies to phocine distemper virus in canadian seals. | 1992 | 1641969 | |
| [evaluation of 5 methods for the diagnosis of infections by respiratory syncytial virus]. | to compare and evaluate four different rapid methods of respiratory syncytial virus antigen detection with the isolation of the virus in cell culture. | 1992 | 1643129 |
| [ultrastructural pathology of congenital infection provoked by respiratory viruses]. | the ultrastructural study of fetal and newborn lungs in the intrauterine infection caused by respiratory viruses showed the virus reproduction to take place in type ii alveolocytes with destructive changes in cell organelles. each type of virus results in a certain picture of ultrastructural changes. progressing cell organelles destruction with an intensive cytoplasm vacuolization and virion presence in the cytoplasmic matrix and on the endoplasmic network membranes is characteristic for influen ... | 1991 | 1648904 |
| viral pneumonitis. | viral pneumonitis can affect all age groups and normal as well as compromised hosts. this article discusses salient features of pneumonitis caused by respiratory syncytial virus, adenoviruses, varicella-zoster virus, herpes simplex virus, influenza a and b viruses, and cytomegalovirus. the clinical picture, diagnosis, treatment and prevention for each agent are discussed. | 1991 | 1649731 |
| pathogenesis of severe acute respiratory infections in the developing world: respiratory syncytial virus and parainfluenza viruses. | respiratory syncytial virus (rsv) and parainfluenza viruses (pivs) are the most frequently isolated pathogens in infants and children with acute lower respiratory infection (lri) in the developed world. less information is available about their importance in lri in the developing world, but they are probably important there also. the pathogenesis of viral bronchiolitis and pneumonia involves inoculation and early replication in the upper respiratory tract, followed by aspiration into the lower r ... | 1991 | 1650494 |
| viral vaccines for the prevention of childhood pneumonia in developing nations: priorities and prospects. | in concert with bacteria, respiratory viruses play a major role in the high rates of acute lower respiratory infection (alri) experienced in developing nations. respiratory syncytial virus, parainfluenza and influenza viruses, and the adenoviruses are the predominant viral causes of alri in both developed and developing regions. in this review, the epidemiologic data from developing nations for these viral infections are summarized and the current status of viral vaccines for prevention of alri ... | 1991 | 1650495 |
| parainfluenza virus pneumonitis in an adult. | parainfluenza virus uncommonly causes fatal giant cell pneumonia in immunocompromised infants and children. to our knowledge, this is the first adult case of parainfluenza virus pneumonia. a 77-year-old woman who was diagnosed as having small-cell carcinoma of the lung underwent chemotherapy. she died of lung edema. analysis of her serum showed antibodies to parainfluenza virus types 2 and 3 at titers of 1:64 and 1:128, respectively. the postmortem examination revealed giant cell pneumonia, in w ... | 1991 | 1650545 |
| vaccination of dogs with multi-component vaccines. | 1991 | 1652929 | |
| sequence characterization of the matrix protein genes of parainfluenza virus types 4a and 4b. | the complete nucleotide sequences of the matrix protein (m) genes of parainfluenza virus types 4a and 4b (piv-4a and -4b) were determined from cdna of the mrna, and found to be 1548 bases in length, exclusive of poly(a) sequences. the sequences contained a large open reading frame of 1146 nucleotides encoding 362 amino acids. a high degree of identity (96.1%) was observed between the amino acid sequences of piv-4a and piv-4b m. these m sequences were compared with those of 10 other paramyxovirus ... | 1991 | 1654379 |
| molecular relationships between human parainfluenza virus type 2, and simian viruses 41 and 5: determination of nucleoprotein gene sequences of simian viruses 41 and 5. | the nucleotide sequences of cdnas of the simian virus 5 (sv5) nucleoprotein (np) gene, and the 3' end of the genome and np gene of sv41 were determined. the open reading frames of the sv5 and sv41 np genes encode polypeptides with mrs of 56,582 and 60,575, respectively, values which are consistent with those estimated by sds-page. the np of human parainfluenza virus type 2 (hpiv-2) was more closely related to that of sv41 (amino acid sequence identity 70.5%) than that of sv5 (57.0%); the amino a ... | 1991 | 1654380 |
| [the role of viruses in the pathogenesis of myocarditis and dilated cardiomyopathy]. | 1991 | 1656127 | |
| [interactions between mycoplasma and human and animal viruses. ultrastructural analysis]. | presented are the data on the ultrastructural analysis of interaction between mycoplasma and certain cancerogenic and infectious viruses in humans and animals. revealed are spontaneous associations of mycoplasma with viruses of cattle leukemia, t-cell human leukemia and with a representative of bunyaviruses. immediate interaction of these agents is found possible. simulated complexes of mycoplasma with infectious viruses are developed. electron microscopy on supramolecular levels revealed immedi ... | 1991 | 1656621 |
| in vitro cytopathogenicity and in vivo virulence of two strains of canine parainfluenza virus. | in vivo and in vitro properties of two strains of canine parainfluenza virus (cpiv) were investigated. one strain, designated cpiv(+), induced syncytial giant cell formation and cytolysis in vitro, whereas the second strain, cpiv(-), caused only a mild strand-forming cytopathic effect with few, small syncytial giant cells. vero cells infected with cpiv(+) or cpiv(-) were 100% positive for cpiv antigen as determined by immunofluorescent staining; however, 100% of cpiv(+) and less than 10% of cpiv ... | 1991 | 1659020 |
| viral pneumonia. | viral pneumonias are common in infants and young children but rare in adults. respiratory syncytial virus (rsv) and para-influenza viruses are the most frequent viral pathogens in infants and children. influenza virus types a and b account for over one half of viral pneumonias in adults. immunocompromised hosts are susceptible to pneumonias caused by cytomegalovirus (cmv) and other herpesviruses, as well as rubeola and adenovirus. diagnosis of viral pneumonia depends on appropriate viral culture ... | 1991 | 1659594 |
| detection of rotavirus antigen in tracheal aspirates of infants and children with pneumonia. | clinical manifestations of respiratory tract infection often precede or coincide with rotavirus gastroenteritis in infants and children. to investigate the possible association between respiratory tract manifestations and rotavirus infection, the authors determined human rotavirus (hrv) antigen and respiratory syncytial virus (rsv) antigen in tracheal aspirates of 58 children with clinically diagnosed pneumonia by enzyme-linked immunosorbent assay (elisa) and immunofluorescent antibody technique ... | 1991 | 1661224 |
| a calcium-channel antagonist can prevent paramyxovirus-induced neurodegeneration. | mumps virus caused a partially lytic infection in cultivated rat embryonic dorsal root ganglion neurons with a restricted formation of viral components. the neuronal degeneration was markedly enhanced by increasing the calcium concentration of the medium and could be almost totally inhibited by the dihydropyridine calcium channel antagonist nifedipine. the drug had no effect on a productive and completely lytic sendai virus infection of the neurons. a previous neurophysiological study has shown ... | 1991 | 1662994 |
| intranasal infection of ferrets (mustela putorius furo) with canine parainfluenza virus. | immunocompetent and cyclophosphamide-immunosuppressed ferrets were intranasally infected with canine parainfluenza virus (cpiv) and observed for clinical signs, histopathologic lesions, the immunocytochemical demonstration of cpiv antigen in the respiratory tract and scanning electron microscopic alterations of the tracheal epithelium until 36 days post infection (p.i.). in both groups, clinical signs were minimal, restricted to the upper respiratory tract and consisted of cough elicited by trac ... | 1991 | 1663681 |
| isolation of a turkey rhinotracheitis-like virus from broiler breeder chickens in england. | 1991 | 1664552 | |
| noninfluenza respiratory virus infection in long-term care facilities. | 1991 | 1664843 | |
| [respiratory syncytial virus and immune response: from the diagnosis of infection to prospects of vaccination]. | 1991 | 1665219 | |
| [from prevention to treatment of respiratory syncytial virus infections]. | 1991 | 1665220 | |
| [follow-up of epidemic viral infections in nurseries of rhone during 2 consecutive years]. | 1991 | 1665223 | |
| [respiratory syncytial virus, a pathogenic agent of the respiratory system]. | 1991 | 1665224 | |
| in vitro virucidal activity of selected anthraquinones and anthraquinone derivatives. | anthraquinones and anthraquinone derivatives were characterized for their antiviral and virucidal activities against viruses representing several taxonomic groups. one of these compounds, hypericin, had activity against vesicular stomatitis virus, herpes simplex virus types 1 and 2, parainfluenza virus, and vaccinia virus (from 0.5 to 3.8 log10 reductions in infectivity) at concentrations of less than 1 microgram/ml as determined by a direct pre-infection incubation assay. human rhinovirus was n ... | 1991 | 1665961 |
| [the protective action of arbidol during a rise in respiratory diseases in 1990]. | prophylactic properties of a new chemical drug, arbidol, against acute respiratory diseases (ard) were studied. arbidol given daily in a dose of 0.2 g for 19 days reduced the morbidity rate 2.3-fold in adults during an outbreak of ard. geometric mean titres of antibodies to respiratory viruses among healthy persons did not change after treatment with arbidol indicating the lack of immunosuppressive properties in the drug. the prophylactic effect of arbidol may be due to both specific effect of t ... | 1991 | 1666474 |
| respiratory infections in children. | 1991 | 1669801 | |
| hepatitis g? | 1991 | 1673502 | |
| viral subunit vaccines. | 1991 | 1673759 | |
| humanised monoclonal antibody to respiratory syncytial virus. | 1991 | 1674780 | |
| characteristics of successive epidemics of respiratory syncytial virus infection. | 1991 | 1681283 | |
| respiratory syncytial virus in children's hospitals. | 1991 | 1683996 | |
| naturally occurring human parainfluenza type 3 viruses exhibit divergence in amino acid sequence of their fusion protein neutralization epitopes and cleavage sites. | many human parainfluenza type 3 virus (piv3) strains isolated from children with respiratory illness are resistant to neutralization by monoclonal antibodies (mabs) which recognize epitopes in antigenic site a or b of the fusion (f) protein of the prototype 1957 piv3 strain. the f protein genes of seven piv3 clinical isolates were sequenced to determine whether their neutralization-resistant phenotypes were associated with specific differences in amino acids which are recognized by neutralizing ... | 1990 | 1689394 |
| antibody response in children to antigen sites on human piv-3 hn: correlation with known epitopes mapped by monoclonal antibodies. | the antibody response in children to known epitopes on the hn of human parainfluenza virus type 3 was investigated. children's sera with haemagglutination-inhibition titres between 1/480 to 1/1280 were used. when tested by elisa, this high-titre serum from each of five children blocked 7 of 17 specific anti-hn murine monoclonal antibodies by greater than 75% at 1 micrograms well-1 of antigen. however, four monoclonal antibodies were blocked less than or equal to 30%, while six were partially blo ... | 1990 | 1690489 |
| viral rna and protein synthesis in two llc-mk2 cell lines persistently infected with human parainfluenza virus 3. | two lines of llc-mk2 cells persistently infected with human parainfluenza virus 3 (hpiv-3) have been maintained in culture for approximately 3 years. subgenomic rnas (putative defective interfering particle genomes) were detected in virions released from both persistently infected cultures. in one of the persistently infected cell lines cyclic variation in the production of virions containing standard virus genomic-size (50s) rna and subgenomic rna was observed. the molar ratio of subgenomic rna ... | 1990 | 1693460 |
| antibody responses of humans and nonhuman primates to individual antigenic sites of the hemagglutinin-neuraminidase and fusion glycoproteins after primary infection or reinfection with parainfluenza type 3 virus. | an unusual feature of human parainfluenza virus type 3 (piv3) is ita ability to cause reinfection with high efficiency. the antibody responses of 45 humans and 9 rhesus monkeys to primary infection or subsequent reinfection with piv3 were examined to identify deficiencies in host immunologic responses that might contribute to the ability of the virus to cause reinfection with high frequency. antibody responses in serum were tested by using neutralization and hemagglutination inhibition (hi) assa ... | 1990 | 1695256 |
| demonstration of respiratory syncytial virus in an autopsy series. | respiratory syncytial virus (rsv) antigen was demonstrated in formalin-fixed, paraffin-embedded autopsy tissue using an immunoperoxidase technique. eighteen autopsy cases were selected on the basis of one of the following criteria: a positive culture for rsv, antemortem or postmortem; positive elisa test for rsv, antemortem or postmortem; or postmortem histology suggestive of paramyxovirus infection. controls included three cases from which parainfluenza or influenza virus had been cultured and ... | 1990 | 1695371 |
| antigenic variation of human and bovine parainfluenza virus type 3 strains. | three human and six bovine parainfluenza virus type 3 (piv3) strains were examined by the use of 60 monoclonal antibodies (mabs). fifty-three mabs to the human c243 strain were directed against six, four, nine and seven epitopes of the haemagglutinin-neuraminidase (hn), fusion (f), nucleocapsid (n) and matrix proteins, respectively. seven mabs to the bovine strain were directed against three epitopes of the hn protein and three epitopes of the f protein. each strain was characterized in elisa an ... | 1990 | 1695673 |
| strain variation in parainfluenza virus type 4. | variations in epitopes on structural proteins of four isolates of parainfluenza virus type 4 (piv-4) and the mr of polypeptides in these isolates were determined by radioimmune precipitation assay with monoclonal antibodies to parainfluenza virus type 4a (piv-4a) and type 4b (piv-4b). three isolates antigenically resembled the prototype piv-4a and the sizes of their structural proteins were 72k (hn protein), 61k (f0 protein), 61k (np protein) and 40k (m protein). however, one virus isolate showe ... | 1990 | 1695674 |
| respiratory syncytial virus: virology, diagnosis, and vaccination. | attempts to develop a respiratory syncytial virus vaccine have revealed the antigenic heterogeneity of the virus and have highlighted the difficulties of inducing protective responses in very young infants. of the two subgroups of the virus, a and b, that cocirculate, a appears to be the most aggressive in infants, but protection against both will be required. although a degree of protection is transferred from mother to the infant via the placenta and by breast feeding, the mechanisms of protec ... | 1990 | 1696677 |
| the respiratory syncytial virus subgroup b attachment glycoprotein: analysis of sequence, expression from a recombinant vector, and evaluation as an immunogen against homologous and heterologous subgroup virus challenge. | the attachment glycoprotein g of respiratory syncytial (rs) virus is important in both the antigenic and molecular diversity of the rs viruses. previous work has shown that the glycoprotein g of a subgroup a rs virus expressed from a recombinant vaccinia virus provides significant protection against homologous but not heterologous subgroup virus challenge. we undertook the cdna cloning and nucleotide sequencing of the g mrna of a subgroup b rs virus (8/60) to extend molecular comparisons of the ... | 1990 | 1697126 |
| a subgroup-specific antigenic site in the g protein of respiratory syncytial virus forms a disulfide-bonded loop. | an antigenic site (represented by 15 amino acids, residues 174 to 188, designated peptide 12) of the large glycoprotein g of respiratory syncytial virus was demonstrated to be subgroup specific in peptide enzyme-linked immunosorbent assay tests with murine monoclonal antibodies and human postinfection sera. the role of individual amino acids in this subgroup-specific site was determined by use of single-amino-acid-deletion sets of peptides. when monoclonal antibodies were reacted with the deleti ... | 1990 | 1697913 |
| synthetic peptides corresponding to the f protein of rsv stimulate murine b and t cells but fail to confer protection. | we have previously located a major neutralization site of the fusion protein of respiratory syncytial virus (rsv) in the polypeptide region extending from amino acids ile221 to glu232. in this report, 8 peptides corresponding to the six major hydrophilic regions of the f1 subunit were selected to analyse their immunogenic and protective capacities as well as their ability to block the high neutralization activities of 4 monoclonal antibodies (mabs). only 5 of the 8 peptides tested induced specif ... | 1991 | 1706591 |
| identification of an epitope on the p and v proteins of simian virus 5 that distinguishes between two isolates with different biological characteristics. | two canine isolates of simian virus 5 (sv5), termed cpi+ and cpi-, were examined for their ability to react with a bank of monoclonal antibodies (mabs) that had been previously raised against a human isolate of sv5. cpi- virus was originally isolated from the brain of a gnotobiotic dog infected with cpi+ virus and establishes persistent infections more readily than cpi+ in vitro. of more than 50 mabs tested, only one (p-k) reacted with cpi+ but not cpi-, enabling distinction between the two cani ... | 1991 | 1713260 |
| psychological stress and susceptibility to the common cold. | it is not known whether psychological stress suppresses host resistance to infection. to investigate this issue, we prospectively studied the relation between psychological stress and the frequency of documented clinical colds among subjects intentionally exposed to respiratory viruses. | 1991 | 1713648 |
| use of intravenous gamma globulin to passively immunize high-risk children against respiratory syncytial virus: safety and pharmacokinetics. the rsvig study group. | infants with cardiopulmonary disease develop severe illness from respiratory syncytial virus (rsv) infection. safety, feasibility, and pharmacokinetics of intravenous gamma globulin (ivig) to prevent rsv illness were studied in 23 high-risk infants in a phase i trial. ivig with an rsv neutralizing antibody titer of 1:1,100 in 5% solution was given monthly over a 2- to 4-h period in a clinical setting during the rsv season. the first group (n = 7) received 500 mg/kg of body weight, the second gro ... | 1991 | 1718213 |
| phocine distemper virus is phylogenetically related to canine distemper virus. | 1991 | 1720585 | |
| protection of balb/c mice from respiratory syncytial virus infection by immunization with a synthetic peptide derived from the g glycoprotein. | a synthetic peptide homologous to amino acids 174-187 of the g glycoprotein of the a2 strain of human respiratory syncytial (rs) virus (g/174-187) was shown to induce protection from live virus challenge of balb/c mice after immunization with three doses of 50 micrograms of peptide coupled to keyhole limpet hemocyanin. immunized mice showed high levels of circulating rs-specific antibodies as detected by elisa assay; however, no neutralizing antibodies were found. moreover, an important short-te ... | 1991 | 1720589 |
| [indices of the humoral response to respiratory syncytial virus infection in children with acute bronchitis]. | examinations of 30 children with acute bronchitis have revealed a respiratory syncytial (rs) viral infection in 18. a reduced response to rs virus was seen in patients with bronchitis complicated by obstruction, in contrast to that in cases without obstruction. humoral response to this virus was reduced and delayed in younger children as against that in elder ones. even high levels of specific igg did not result in vitro neutralization of rs virus. | 1991 | 1724037 |
| respiratory syncytial virus infections in pediatric liver transplant recipients. | respiratory syncytial virus (rsv) is the most important cause of lower respiratory tract infection in infants and young children. the charts of 17 children found to have rsv among 493 children who underwent liver transplantation between february 1985 and february 1991 were reviewed. the median age at diagnosis was 20 months. median time of diagnosis was 24 days after transplantation. thirteen patients developed nosocomial infections while convalescing from their transplant. common symptoms inclu ... | 1992 | 1727886 |
| impact of influenza virus infection as a cause of pediatric hospitalization. | from winter 1989 to spring 1990, a severe epidemic caused by influenza a (h3n2) and b viruses developed in japan. during the epidemic (december 1989 to february 1990), 244 children were admitted to the pediatric ward of nippon kokan hospital: 53 (21.7%) were hospitalized with influenza virus infection, 22 (9.0%) with rotavirus gastroenteritis, and 17 (7.0%) with respiratory syncytial virus infection. among those with influenza, 24 had type a and 29 had type b. most were young healthy children wi ... | 1992 | 1730904 |
| eosinophil degranulation in the respiratory tract during naturally acquired respiratory syncytial virus infection. | eosinophil cationic protein (ecp), a cytotoxic protein contained in the granules of eosinophils, has been suggested as having an important role in the pathogenesis of asthma. to determine whether ecp plays a similar role in bronchiolitis, we tested samples of nasopharyngeal secretions, obtained from a group of 47 children with various forms of illness related to respiratory syncytial virus (rsv) and from 26 children with non-rsv upper respiratory tract illness or bacterial pneumonia, for the pre ... | 1992 | 1731020 |
| resistance to respiratory syncytial virus (rsv) challenge induced by infection with a vaccinia virus recombinant expressing the rsv m2 protein (vac-m2) is mediated by cd8+ t cells, while that induced by vac-f or vac-g recombinants is mediated by antibodies. | it was previously demonstrated that the vaccinia virus recombinants expressing the respiratory syncytial virus (rsv) f, g, or m2 (also designated as 22k) protein (vac-f, vac-g, or vac-m2, respectively) induced almost complete resistance to rsv challenge in balb/c mice. in the present study, we sought to identify the humoral and/or cellular mediators of this resistance. mice were immunized by infection with a single recombinant vaccinia virus and were subsequently given a monoclonal antibody dire ... | 1992 | 1731105 |
| further studies with short duration ribavirin aerosol for the treatment of influenza virus infection in mice and respiratory syncytial virus infection in cotton rats. | ribavirin aerosol administration has been shown to be effective in the treatment of respiratory syncytial virus (rsv) infections in infants and in influenza a and b virus infections in young adults. long treatment schedules and potential for environmental contamination have stimulated the search for alternative dosing schedules. thus, we attempted to determine the length of time of ribavirin aerosol necessary for effective treatment of influenza and rsv. in rsv-infected cotton rats, aerosolizati ... | 1992 | 1736809 |
| respiratory syncytial virus (rsv): a common health problem. | rsv infections pose a variety of considerations for emergency personnel. nurses should be suspicious of this cause of illness during the winter months because of its prevalence, should be able to recognize and treat those who are experiencing or are at risk for acquiring lower respiratory tract complications, and should be aware of the need to reduce the spread of the virus by using isolation techniques, vigorous hand-washing protocol, and other protective measures to reduce contact with the org ... | 1992 | 1740879 |
| respiratory syncytial virus pneumonia in hospitalized adults. | 1991 | 1747009 | |
| cytokine (tumor necrosis factor, il-6, and il-8) production by respiratory syncytial virus-infected human alveolar macrophages. | human alveolar macrophages (am) are susceptible to infection with respiratory syncytial virus (rsv), but the infection is abortive after the initial cycles of virus replication. we have investigated if rsv infection of am results in the production of cytokines tnf, il-6, and il-8, all of which may modulate inflammatory and immune responses to the virus, as well as may directly protect respiratory epithelial cells against spread of infection. within 1 h after interaction with rsv, increased mrna ... | 1991 | 1753101 |
| high dose-short duration ribavirin aerosol treatment--a review. | a high-dose, short-duration treatment with ribavirin aerosol consisting of a three-fold increase in concentration of drug (60 mg versus 20 mg of ribavirin per ml in the liquid reservoir of the generator administered for about one-third the time of the standard treatment) was as effective as the standard dosage in the treatment of experimental influenza a and b infections in mice and in the treatment of experimental respiratory syncytial virus infection in cotton rats. despite some minor pulmonar ... | 1991 | 1756300 |
| occurrence of respiratory syncytial virus subtypes in hospitalized children in cleveland, ohio from 1985 to 1988. | in order to determine the frequency of occurrence of the two respiratory syncytial virus (rsv) subtypes in hospitalized children in cleveland, ohio, we analyzed clinical isolates obtained during three consecutive winter epidemic seasons between 1985 and 1988. rsv was recovered from the frozen clinical specimens of 197 patients: 176 subtype a, and 21 subtype b. subtype a predominated during all three epidemic seasons, ranging from 83 to 94% of isolates. we surveyed the clinical records of 16 chil ... | 1991 | 1758737 |
| attempt to vaccinate orally harbour seals against phocid distemper. | 1991 | 1759340 | |
| potential danger of avian paramyxovirus type 3 to ornithological collections. | 1991 | 1759341 | |
| "management of the infant with respiratory syncytial virus". | 1991 | 1762047 | |
| the cold war against rsv. | respiratory syncytial virus (rsv) can cause substantial morbidity and mortality in high risk patients. the authors discuss prevention and treatment of this virus. | 1991 | 1765449 |
| [pneumonia caused by respiratory syncytial virus in the adult]. | 1991 | 1768759 | |
| ventilatory casebook. respiratory syncytial virus infection complicating bronchopulmonary dysplasia. | 1991 | 1770400 |