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anti-inflammatory drugs and herbs with special emphasis on herbal medicines for countering inflammatory diseases and disorders - a review.diseases with inflammatory etiopathology have increased in incidence in recent times. drugs used for therapeutic management of such inflammatory diseases are relieving the ailment but at the same time also countering serious life-threatening consequences. moreover, they are costly and rarely available at all places. in this context, research and development on medicinal herbs have opened a new era in the prophylactic and therapeutic management of inflammatory diseases.201829336271
inhibitory activity of chokeberry, bilberry, raspberry and cranberry polyphenol-rich extract towards adipogenesis and oxidative stress in differentiated 3t3-l1 adipose cells.berries are a rich source of antioxidants and phytochemicals that have received considerable interest for their possible relations to human health. in this study, the anti-adipogenic effect of polyphenol-rich extract obtained from chokeberry aronia melanocarpa (michx.) elliot, raspberry rubus idaeus l., bilberry vaccinium myrtillus l. and cranberry vaccinium macrocarpon aiton fruits and its underlying molecular mechanisms were investigated in differentiated 3t3-l1 adipose cells. treatment with t ...201729182628
hypoglycemic and hypolipidemic effect of vaccinium myrtillus l. leaf and phaseolus vulgaris l. seed coat extracts in diabetic rats.the aim of this study was to examine the hypoglycemic and hypolipidemic effects of vaccinium myrtillus l. leaf (vle) and phaseolus vulgaris l. seed coat (pce) plant extracts, containing polyphenolic compounds, on carbohydrate and lipid metabolism in wistar rats with streptozotocin (stz) and high-fructose diet (hfd)-induced diabetes.201728760419
recovery of anthocyanins from residues of rubus fruticosus, vaccinium myrtillus and eugenia brasiliensis by ultrasound assisted extraction, pressurized liquid extraction and their combination.this work investigated the extraction efficiency of polyphenols (anthocyanins) from blackberry, blueberry and grumixama residues using combined ultrasonic assisted extraction (uae) and pressurized liquid extraction (ple) (uae+ple). the performance of uae+ple was compared to those achieved by the isolated ple and uae methods and conventional soxhlet extraction. the effects of the extraction methods and solvents (acidified water ph 2.0, ethanol+water 50% v/v and ethanol+water 70% ethanol v/v) on t ...201728449984
profiling of iridoid glycosides in vaccinium species by uhplc-ms.the iridoid profile of four vaccinium species was investigated using uhplc-ms to obtain further information about this group of species for phytochemical characterization. fruits of bog bilberry (vaccinium uliginosum l.) showed 14 different iridoid glycosides with a total amount of 20mg/kg fresh weight (fw), whereas bilberry (vaccinium myrtillus l.) contained 11 iridoid glycosides and a total amount of 127mg/kg fw. highbush blueberry (vaccinium corymbosum l.) and lowbush blueberry (vaccinium ang ...201728964369
anthocyanin profile, antioxidant activity and enzyme inhibiting properties of blueberry and cranberry juices: a comparative study.cranberry (vaccinium macrocarpon) and blueberry (vaccinium myrtillus) juices are commonly consumed as a source of antioxidants. the aim of this study was to compare bioactivities as well as the differences in the polyphenol content and anthocyanin profile of both juices. polyphenol and anthocyanin contents were quantified using spectrophotometric and chromatographic methods. bioassays were carried out in terms of antioxidant properties in cell and cell free systems as well as inhibition of physi ...201729038797
liquid chromatographic/electrospray ionization quadrupole/time of flight tandem mass spectrometric study of polyphenolic composition of different vaccinium berry species and their comparative evaluation.ultra-high-performance liquid chromatography coupled with high-resolution quadrupole-time of flight mass spectrometry with both negative and positive ionization was used for comprehensively investigating the phenolic and polyphenolic compounds in berries from three spontaneous or cultivated vaccinium species (i.e., vaccinium myrtillus, vaccinium uliginosum subsp. gaultherioides, and vaccinium corymbosum). more than 200 analytes, among phenolic and polyphenolic compounds belonging to the classes ...201727847974
a brief review of blue- and bilberries' potential to curb cardio-metabolic perturbations: focus on diabetes.some epidemiological studies suggest that increased consumption of anthocyanins is associated with lower risk of cardiovascular disease (cvd) and hypertension. also, high consumption of anthocyanin-rich fruit, such as berries, is associated with a lower risk of developing type 2 diabetes (t2d). in this review, we briefly yet critically assess the available evidence in support of an anti-diabetic role of anthocyanins derived from berries, especially bilberry (vaccinium myrtillus l., also known as ...201727748191
enhanced glucose uptake in human liver cells and inhibition of carbohydrate hydrolyzing enzymes by nordic berry extracts.a western lifestyle with low physical activity and a diet rich in sugar, fat and processed food contribute to higher incidences of diabetes and obesity. enhanced glucose uptake in human liver cells was observed after treatment with phenolic extracts from different nordic berries. all berry extracts showed higher inhibition against α-amylase and α-glucosidase than the anti-diabetic agent acarbose. total phenolic content and phenolic profiles in addition to antioxidant activities, were also invest ...201729064442
a wild 'albino' bilberry (vaccinium myrtillus l.) from slovenia shows three bottlenecks in the anthocyanin pathway and significant differences in the expression of several regulatory genes compared to the common blue berry type.relative expressions of structural genes and a number of transcription factors of the anthocyanin pathway relevant in vaccinium species, and related key enzyme activities were compared with the composition and content of metabolites in skins of ripe fruits of wild albino and blue bilberry (vaccinium myrtillus) found in slovenia. compared to the common blue type, the albino variant had a 151-fold lower total anthocyanin and a 7-fold lower total phenolic content in their berry skin, which correlat ...201729272302
the protective effects of whortleberry extract against cisplatin-induced ototoxicity in rats.cisplatin is one of the main chemotherapeutic agents used for the treatment of many types of cancer. however, ototoxicity, one of the most serious side effects of cisplatin, restricts its usage.201729174583
phytochemical properties and antioxidant activities of extracts from wild blueberries and lingonberries.among vaccinium species, blueberries (vaccinium myrtillus l.) and lingonberries (vaccinium vitis-idaea) are popular in the human diet. in this study, total phenolic, total flavonoid and total monomeric anthocyanin contents in the ethanol-water extracts of blueberry and lingonberry fruits grown wild in the forests in the central region of poland were assayed. antioxidant activities of the extracts from each plant were also evaluated for scavenging ability on 1,1-diphenyl-2-picrylhydrazyl (dpph) r ...201729134464
both seed germination and seedling mortality increase with experimental warming and fertilization in a subarctic tundra.climate change is expected to force many species in arctic regions to migrate and track their climatic niche. this requires recruitment from seed, which currently shows very low rates in arctic regions, where long-lived and vegetatively reproducing plants dominate. therefore, we pose the question whether recruitment (germination and seedling establishment) in arctic regions will significantly improve in a warmer world, and thus allow species to follow their climatic niche. we used a full factori ...201729026511
skin penetration and uv-damage prevention by nanoberries.ethanolic extract from blueberry (vaccinium myrtillus) is rich in anthocyanins and thus exhibits antioxidant activity. on the other hand, ultradeformable liposomes are capable of penetrating to the impermeable barrier of skin. nanoberries are ultradeformable liposomes carrying blueberry extract.201728975707
influence of different fermentation strategies on the phenolic profile of bilberry wine (vaccinium myrtillus l.).polyphenol rich and especially anthocyanin rich berries like bilberries (vaccinium myrtillus l.) and derived products such as wine have enjoyed increasing popularity. during winemaking and aging, the phenolic profile undergoes distinct changes, a phenomenon that has been well investigated in grape wine but not in bilberry wine. the present study determined the influence of different fermentation strategies including various pre- and postfermentative heating and cooling concepts on the phenolic p ...201728749662
effect of extracts of bilberries (vaccinium myrtillus l.) on amyloglucosidase and α-glucosidase activity.vaccinium myrtillus l. is a species belonging to the genus vaccinium of the family ericaceae. bilberries have drawn attention due to the multiple benefits for the human health, including antioxidant, anti-inflammatory, anticancer, anti-neurodegenerative, and cardioprotective effects. recently, bilberries were shown to inhibit the activity of carbohydrate-hydrolysing enzymes that can help reduce the intensity of the metabolic syndrome and prevent type 2 diabetes.201728704188
fasting serum hippuric acid is elevated after bilberry (vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes.urinary hippuric acid has been proposed as a biomarker for fruit, vegetable, and polyphenol consumption. we assessed how serum hippuric acid changes after a bilberry-enriched diet (bb; high anthocyanin intake) and another berry diet including strawberries, raspberries, and cloudberries (src; lower anthocyanin intake) and how these changes associate with insulin and glucose metabolism.201728556578
pharmacokinetic profile of bilberry anthocyanins in rats and the role of glucose transporters: lc-ms/ms and computational studies.the aim of the present investigation was to better understand the pharmacokinetic profile of bilberry (vaccinium myrtillus) anthocyanins and the role of glucose transporters (sglt1 and glut2) on their absorption. in particular, the absorption of 15 different anthocyanins contained in a standardized bilberry extract (mirtoselect®) was measured in rats by a validated lc-esi-ms/ms approach. the plasma concentration peak (cmax) of 11.1ng/ml was reached after 30min and fasting condition significantly ...201728499643
chemical composition, antioxidant and α-glucosidase-inhibiting activities of the aqueous and hydroethanolic extracts of vaccinium myrtillus leaves.vaccinium myrtillus (bilberry) leaf is traditionally used in southeastern europe for the treatment of diabetes. in the present study, the ability of bilberry leaf extracts to inhibit carbohydrate-hydrolyzing enzymes and restore glutathione concentration in hep g2 cells subjected to glucose-induced oxidative stress was investigated. a comprehensive analysis of the antioxidant activity of two bilberry leaf extracts was performed. the aqueous extract showed excellent total antioxidant and chelating ...201728452948
human intervention study to investigate the intestinal accessibility and bioavailability of anthocyanins from bilberries.we investigated the importance of the large intestine on the bioavailability of anthocyanins from bilberries in humans with/without a colon. low bioavailability of anthocyanins in plasma and urine was observed in the frame of this study. anthocyanins reached the circulation mainly as glucuronides. analysis of ileal effluents (at end of small intestine) demonstrated that 30% of ingested anthocyanins were stable during 8h passage through the upper intestine. only 20% degradants were formed and mos ...201728450007
soil warming opens the nitrogen cycle at the alpine treeline.climate warming may alter ecosystem nitrogen (n) cycling by accelerating n transformations in the soil, and changes may be especially pronounced in cold regions characterized by n-poor ecosystems. we investigated n dynamics across the plant-soil continuum during 6 years of experimental soil warming (2007-2012; +4 °c) at a swiss high-elevation treeline site (stillberg, davos; 2180 m a.s.l.) featuring larix decidua and pinus uncinata. in the soil, we observed considerable increases in the nh4+ poo ...201727207568
how to induce defense responses in wild plant populations? using bilberry (vaccinium myrtillus) as example.inducible plant defense is a beneficial strategy for plants, which imply that plants should allocate resources from growth and reproduction to defense when herbivores attack. plant ecologist has often studied defense responses in wild populations by biomass clipping experiments, whereas laboratory and greenhouse experiments in addition apply chemical elicitors to induce defense responses. to investigate whether field ecologists could benefit from methods used in laboratory and greenhouse studies ...201728331586
four years of experimental warming do not modify the interaction between subalpine shrub species.climate warming can lead to changes in alpine plant species interactions through modifications in environmental conditions, which may ultimately cause drastic changes in plant communities. we explored the effects of 4 years of experimental warming with open-top chambers (otc) on vaccinium myrtillus performance and its interaction with neighbouring shrubs at the pyrenean treeline ecotone. we examined the effects of warming on height, above-ground (ag) and below-ground (bg) biomass and the c and n ...201728190093
vascular plants as ecological indicators of metals in alpine vegetation (karkonosze, sw poland).calluna vulgaris, carex rigida, deschampsia flexuosa, nardus stricta and vaccinium myrtillus are abundant in the vegetation of mountainous areas in northern and central europe. knowledge of their ability to accumulate increased amounts of metals could be useful in the evaluation of environmental pollution in the alpine tundra of high mountains. additionally, this investigation may contribute to understanding the rate and direction of recent vegetation change in karkonosze and similar types of en ...201728702907
bioaccumulation of heavy metals and ecophysiological responses to heavy metal stress in selected populations of vaccinium myrtillus l. and vaccinium vitis-idaea l.the aim of this study was to determine the concentrations of heavy metals (cd, pb, zn, fe, and mn) in soil, and their bioavailability and bioaccumulation in vaccinium myrtillus l. and vaccinium vitis-idaea l. organs. analysis also concerned the physiological responses of these plants from three polluted sites (immediate vicinity of a zinc smelter in miasteczko śląskie, arcelormittal poland s.a. iron smelter in dąbrowa górnicza-łosień, and jaworzno iii power plant in jaworzno) and one pseudo-cont ...201728624857
understanding the drivers of extensive plant damage in boreal and arctic ecosystems: insights from field surveys in the aftermath of damage.the exact cause of population dieback in nature is often challenging to identify retrospectively. plant research in northern regions has in recent decades been largely focussed on the opposite trend, namely increasing populations and higher productivity. however, a recent unexpected decline in remotely-sensed estimates of terrestrial arctic primary productivity suggests that warmer northern lands do not necessarily result in higher productivity. as large-scale plant dieback may become more frequ ...201728558420
inclusion of bilberry pomace in rabbit diets: effects on carcass characteristics and meat quality.a trial was performed to evaluate bilberry pomace (bp) as alternative source of nutrients for rabbits. one hundred and forty-four grimaud weaned rabbits were divided into 4 groups of 36 animals each and fed ad libitum with a basal diet (bp0) tested against three assay diets developed by substituting 50, 100 and 150g/kg of the bp0 diet with bp (bp5, bp10 and bp15 diets, respectively). carcass characteristics of rabbits were not affected by treatment, with the exception of liver weight. dietary in ...201727838575
bilberry: chemical profiling, in vitro and in vivo antioxidant activity and nephroprotective effect against gentamicin toxicity in rats.we assessed possible protective effect of bilberry diet in rat model of nephrotoxicity. in vivo and in vitro antioxidant activity and chemical profiling of this functional food was performed. with aid of hplc-dad and spectrophotometric method, 15 individual anthocyanins were quantified alongside total tannin, phenylpropanoid, and anthocyanin content. the study was conducted on four groups of rats: control, treated with only gentamicin, treated with only bilberry, and treated with both gentamicin ...201727714928
[current data on the role of anthocyanosides and flavonoids in the treatment of eye diseases].anthocyanins are known to have antioxidant, anti-inflammatory, neuroprotective, and anticarcinogenic activity as well as positive effect on the cardiovascular system. because of bilberry anthocyanosides (vaccinium myrtillus l.), mirtilene forte promotes rhodopsin synthesis and regeneration, increases retinal sensitivity to changes in light intensity, improves visual acuity and dark adaptation as well as blood supply of the retina. studies conducted in russia are aimed at evaluating the use of mi ...201726845880
diversity of fungal assemblages in roots of ericaceae in two mediterranean contrasting ecosystems.the plants belonging to the ericaceae family are morphologically diverse and widely distributed groups of plants. they are typically found in soil with naturally poor nutrient status. the objective of the current study was to identify cultivable mycobionts from roots of nine species of ericaceae (calluna vulgaris, erica arborea, erica australis, erica umbellate, erica scoparia, erica multiflora, arbutus unedo, vaccinium myrtillus, and vaccinium corymbosum). the sequencing approach was used to am ...201728302364
ericoid roots and mycospheres govern plant-specific bacterial communities in boreal forest humus.in this study, the bacterial populations of roots and mycospheres of the boreal pine forest ericoid plants, heather (calluna vulgaris), bilberry (vaccinium myrtillus), and lingonberry (vaccinium vitis-idaea), were studied by qpcr and next-generation sequencing (ngs). all bacterial communities of mycosphere soils differed from soils uncolonized by mycorrhizal mycelia. colonization by mycorrhizal hyphae increased the total number of bacterial 16s ribosomal dna (rdna) gene copies in the humus but d ...201728025668
forbidden fruit: human settlement and abundant fruit create an ecological trap for an apex omnivore.habitat choice is an evolutionary product of animals experiencing increased fitness when preferentially occupying high-quality habitat. however, an ecological trap (et) can occur when an animal is presented with novel conditions and the animal's assessment of habitat quality is poorly matched to its resulting fitness. we tested for an et for grizzly (brown) bears using demographic and movement data collected in an area with rich food resources and concentrated human settlement. we derived measur ...201727677529
temporal effects of hunting on foraging behavior of an apex predator: do bears forego foraging when risk is high?avoiding predators most often entails a food cost. for the scandinavian brown bear (ursus arctos), the hunting season coincides with the period of hyperphagia. hunting mortality risk is not uniformly distributed throughout the day, but peaks in the early morning hours. as bears must increase mass for winter survival, they should be sensitive to temporal allocation of antipredator responses to periods of highest risk. we expected bears to reduce foraging activity at the expense of food intake in ...201627696003
authentication of punica granatum l.: development of scar markers for the detection of 10 fruits potentially used in economically motivated adulteration.the large commercial success of pomegranate increase the likelihood of economically motivated adulteration (ema), which has been gradually spotted with the undeclared addition of anthocyanin-rich plants or cheaper fruit juices used as bulking and diluting agents. a method based on sequence-characterized amplified regions (scars) was developed to detect the presence of aristotelia chilensis, aronia melanocarpa, dioscorea alata, euterpe oleracea, malus×domestica, morus nigra, sambucus nigra, vacci ...201626920316
dietary items as possible sources of (137)cs in large carnivores in the gorski kotar forest ecosystem, western croatia.the mountain forest ecosystem of gorski kotar is distant from any significant sources of environmental pollution, though recent findings have revealed that this region is among the most intense (137)cs contaminated area in croatia. therefore, the aim of this study was to investigate (137)cs and (40)k load in three large predator species in the mountain forest ecosystem. radionuclides mass activities were determined by the gamma-spectrometric method in the muscle tissue of brown bear (47), wolf ( ...201626556746
nutrigenomic activity of plant derived compounds in health and disease: results of a dietary intervention study in dog.the study was conducted to investigate the effects of dietary administrations of four nutraceuticals in dogs. seventy four dogs were enrolled in the trials, 24 healthy dogs were fed with a control diet (ct) and the experimental groups received for 60days the same diet supplemented with nutraceuticals, namely echinacea angustifolia (ea, 0.10mg/kg live weight as echinacoside; 14 dogs), vaccinium myrtillus (vm, 0.20mg/kg live weight as anthocyanidin, 13 dogs), curcuma longa (cl, 6.60mg/kg live weig ...201627892863
natural and anthropogenic radioactivity in the environment of kopaonik mountain, serbia.to evaluate the state of the environment in kopaonik, a mountain in serbia, the activity concentrations of (4) k, (226)ra, (232)th and (137)cs in five different types of environmental samples are determined by gamma ray spectrometry, and radiological hazard due to terrestrial radionuclides is calculated. the mean activity concentrations of natural radionuclides in the soil are higher than the global average. however, with an exception of two sampling locations, the external radiation hazard inde ...201627213569
effect of a complex lutein formula in an animal model for light-induced retinal degeneration.several retinal degenerative diseases cause vision loss and retinal cell death. currently, people face prolonged exposure to digital screens, rendering vision protection from light exposure a critical topic. in this study, we designed a complex lutein formula (clf) by combining several natural compounds: calendula officinalis, lycium barbarum, vaccinium myrtillus, cassia obtusifolia, and rhodiola rosea. in addition, we evaluated the protective effects of the formula on retinal functions in an an ...201627426260
the multifunctionality of berries toward blood platelets and the role of berry phenolics in cardiovascular disorders.diet and nutrition have an important influence on the prophylaxis and progression of cardiovascular disease; one example is the inhibition of blood platelet functions by specific components of fruits and vegetables. garlic, onion, ginger, dark chocolate and polyunsaturated fatty acids all reduce blood platelet aggregation. a number of fruits contain a range of cardioprotective antioxidants and vitamins, together with a large number of non-nutrient phytochemicals such as phenolic compounds, which ...201627778523
ripeip1, a gene from the arbuscular mycorrhizal fungus rhizophagus irregularis, is preferentially expressed in planta and may be involved in root colonization.transcriptomics and genomics data recently obtained from the arbuscular mycorrhizal (am) fungus rhizophagus irregularis have offered new opportunities to decipher the contribution of the fungal partner to the establishment of the symbiotic association. the large number of genes which do not show similarity to known proteins witnesses the uniqueness of this group of plant-associated fungi. in this work, we characterize a gene that was called ripeip1 (preferentially expressed in planta). its expre ...201627075897
bears and berries: species-specific selective foraging on a patchily distributed food resource in a human-altered landscape.when animals are faced with extraordinary energy-consuming events, like hibernation, finding abundant, energy-rich food resources becomes particularly important. the profitability of food resources can vary spatially, depending on occurrence, quality, and local abundance. here, we used the brown bear (ursus arctos) as a model species to quantify selective foraging on berries in different habitats during hyperphagia in autumn prior to hibernation. during the peak berry season in august and septem ...201627217612
black currant (ribes nigrum l.) and bilberry (vaccinium myrtillus l.) fruit juices inhibit adhesion of asaia spp.the aim of the study was to evaluate the activity of high-polyphenolic black currant (ribes nigrum l.) and bilberry (vaccinium myrtillus l.) juices against bacterial strains asaia lannensis and asaia bogorensis isolated as spoilage of commercial soft drinks. the composition of fruit juices was evaluated using chromatographic techniques hplc and lc-ms. the adhesion to glass, polystyrene, and polyethylene terephthalate in two different culture media was evaluated by luminometry and the plate count ...201627747228
effects of drought stress on growth, solute accumulation and membrane stability of leafy vegetable, huckleberry (solanum scabrum mill.).the present study sought to investigate the factors implicated in growth impairment of huckleberry (a leafy vegetable) under water stress conditions. to achieve this, seedlings of plant were subjected to control, mild stress and severe stress conditions for 30 days. plant growth, plant water relation, gas exchange, oxidative stress damage, electrolyte leakage rate, mineral content and osmolyte accumulation were measured. water deficit markedly decreased leaf, stem and root growth. leaf photosynt ...201626930867
controlling type 2 diabetes mellitus with herbal medicines: a triple-blind randomized clinical trial of efficacy and safety.the use of alternative medicines is common in patients with diabetes mellitus. the primary aim of the present study was to determine the effects of cinnamon and caucasian whortleberry (vaccinium arctostaphylos l.) on blood glucose control, lipid profile and body mass index (bmi) in patients with type 2 diabetes (t2dm).201626362826
white versus blue: does the wild 'albino' bilberry (vaccinium myrtillus l.) differ in fruit quality compared to the blue one?wild albino and blue bilberry fruit were analyzed to compare different fruit characteristics linked to the composition of primary and secondary metabolites. compounds were identified using hplc-ms and standard quality parameters were determined. albino berries were significantly smaller, accumulated less water and were characterized by 23% higher dry weight. soluble solids content and ph value were higher in albino bilberry and their surface was lighter and characterized by a yellow hue. both bi ...201627283708
intake of bilberries (vaccinium myrtillus l.) reduced risk factors for cardiovascular disease by inducing favorable changes in lipoprotein profiles.cardiovascular diseases (cvds) are the leading causes of death, and lifestyle modification, including dietary changes, is recommended to improve this condition. in this study, regular consumption of bilberries was hypothesized to have beneficial effects on cvd risk reduction, by changes in human health indicators such as decreasing low-density lipoprotein cholesterol (ldl-c) and triglycerides (tgs) and increasing high-density lipoprotein cholesterol (hdl-c). the research involved women (n=25) an ...201627993193
interaction between κ- and ι-carrageenan and anthocyanins from vaccinium myrtillus.anthocyanins (atcs) from the vaccinium myrtillus water extract have been incorporated into the κ-carrageenan (κ-carg) or ι-carrageenan (ι-carg) during complexation in dilute solutions or adsorption onto the microgranules of κ-carg or ι-carg cross-linked with epichlorohydrin. at the optimal weight ratio of carg to atc at 0.4:1 and the total atcs and carg concentration≤0.07g/l, stable dispersions of the κ-carg/atcs or ι-carg/atcs complex nanosize particles were obtained. the langmuir, freundlich a ...201627185113
bilberry extracts are not created equal: the role of non anthocyanin fraction. discovering the "dark side of the force" in a preliminary study.several experimental studies and clinical trials support the potential of bilberry (vaccinium myrtillus l) extracts in promoting eye health and circulation. many active ingredients have been isolated from the berries and leaves of the bilberry plant. however, anthocyanins represent the most widely studied bioactive compounds in this plant.201627338070
carotenoid metabolism during bilberry (vaccinium myrtillus l.) fruit development under different light conditions is regulated by biosynthesis and degradation.carotenoids are important pigments and precursors for central signaling molecules associated in fruit development and ripening. carotenoid metabolism has been studied especially in the climacteric tomato fruit but the content of carotenoids and the regulation of their metabolism have been shown to be highly variable between fruit species. non-climacteric berries of the genus vaccinium are among the best natural sources of health-beneficial flavonoids but not studied previously for carotenoid bio ...201627098458
the effects of vaccinium myrtillus extract on hamster pial microcirculation during hypoperfusion-reperfusion injury.the present study was aimed to assess the in vivo hamster pial microvessel alterations due to 30 min transient bilateral common carotid artery occlusion (bccao) and reperfusion (60 min); moreover, the neuroprotective effects of vaccinium myrtillus extract, containing 34.7% of anthocyanins, were investigated.201627070318
polyphenolic profiles and antioxidant and antiradical activity of italian berries from vaccinium myrtillus l. and vaccinium uliginosum l. subsp. gaultherioides (bigelow) s.b. young.total soluble polyphenols (tsp), total monomeric anthocyanins (tma), radical scavenging activity (rsa), ferric reducing antioxidant power (frap), and a number of anthocyanins, phenolic acids, coumarins, flavanols, dihydrochalcones and flavonols were investigated in tuscan bilberry (i.e. vaccinium myrtillus) and "false bilberry" (i.e. vaccinium uliginosum subsp. gaultherioides bigelow). v. myrtillus berries showed much higher tsp, tma, rsa and frap values than v. uliginosum subsp. gaultherioides ...201626988491
anti-inflammatory activity of berry fruits in mice model of inflammation is based on oxidative stress modulation.many fruits have been used as nutraceuticals because the presence of bioactive molecules that play biological activities.201627114691
in vitro study of biological activities of anthocyanin-rich berry extracts on porcine intestinal epithelial cells.anthocyanins, compounds that represent the major group of flavonoids in berries, are one of the most powerful natural antioxidants. the aim of this study was to evaluate biological activities and comparison of anthocyanin-rich extracts prepared from chokeberry (aronia melanocarpa), elderberry (sambucus nigra), bilberry (vaccinium myrtillus) and blueberry (v. corymbosum) on the porcine intestinal epithelial ipec-1 cell line.201625801092
anti-hyperglycemic and anti-hyperlipidemic effects of vaccinium myrtillus fruit in experimentally induced diabetes (antidiabetic effect of vaccinium myrtillus fruit).diabetes mellitus (dm) is a metabolic disorder that is associated with an increased risk of cardiovascular disease. vaccinium myrtillus (bilberry) is a useful plant with antidiabetic properties in traditional medicine. the aim of this study was to investigate the effects of bilberry against dm. diabetes was induced using intraperitoneal injection of alloxan (120 mg kg(-1) body weight (bw)). bilberry powder (2 g d(-1)) and glibenclamide (positive control; 0.6 mg kg(-1) bw) were administered for 4 ...201625704796
nanoberries for topical delivery of antioxidants.with the aim of improving the antioxidant activity of polyphenols from blueberries (vaccinium myrtillus) on skin targets after topical application, ethanolic extracts from three blueberry varieties (named millenia, o'neal, and blue crisp) were loaded into ultradeformable liposomes. these nanocarriers are known to be capable of penetrating through the stratum corneum reaching its deeper layers and the viable epidermis. on the other hand, blueberries contain large amounts of polyphenols, whose ant ...201624397884
anthocyanin suppresses the toxicity of aβ deposits through diversion of molecular forms in in vitro and in vivo models of alzheimer's disease.the pathogenesis of alzheimer's disease (ad) is strongly correlated with the aggregation and deposition of the amyloid beta (aβ1-42) peptide in fibrillar form, and many studies have shown that plant-derived polyphenols are capable of attenuating ad progression in various disease models. in this study, we set out to correlate the effects of anthocyanoside extracts (vaccinium myrtillus anthocyanoside (vma)) obtained from bilberry on the in vitro progression of aβ fibril formation with the in vivo ...201626304685
new liquid chromatography method with ultraviolet detection for analysis of anthocyanins and anthocyanidins in vaccinium myrtillus fruit dry extracts and commercial preparations.the vaccinium myrtillus fruits (bilberry) are a well-known anthocyanins source, and their extracts are widely used in dietary botanicals and pharmaceutical products for the treatment of vascular and vision disorders. different analytical methods used for standardization of the bilberry extracts and their preparations are available from pharmacopeias and from the literature. however, the methods reported in the literature do not allow the detection of free anthocyanidins, which are markers of poo ...201617760327
effect of vaccinium myrtillus anthocyanosides on ischaemia reperfusion injury in hamster cheek pouch microcirculation.the effects of vaccinium myrtillus anthocyanosides (vma) on ischaemia reperfusion injury were investigated in the hamster cheek pouch microcirculation. ischaemia was induced by clamping the cheek pouch for 30 min followed by 30 min of reperfusion. the microvasculature was visualized by a fluorescence technique. vma [10 mg (100 g body weight)-1] were orally administered for 2 and 4 weeks. the number of adhering leukocytes to venular vessel walls, the perfused capillary length, the increase in per ...20157630857
[effectiveness of phytotherapy in supportive treatment of type 2 diabetes mellitus billberry (vaccinium myrtillus)].the billberry is well-known for its tasty blue-dyeing fruits. historically the leaves and fruits were used to treat diabetes, cardiovascular diseases, dementia and cancer. antidiabetic properties of the plant are attributed mostly to the content of anthocyanins and polyphenols. these compounds have proven their antidiabetic potential in various studies. their mechanism of action is an increase in insulin secretion (anthocyanin pelargonidin), reduction of insulin resistance (anthocyanin cyanidin- ...201526084642
complexes of dextran sulfate and anthocyanins from vaccinium myrtillus: formation and stability.to improve the stability and antioxidant activity of anthocyanins (atc), complexes of dextran sulfate (desu) and atc extracted from vaccinium myrtillus were formed during electrostatic interaction between sulfo groups of desu and cationic moieties of atc. at the optimal weight ratio desu/atc=0.4 g/g, the amount of atc introduced into a complex depended on the total concentration of the reagents. about 1.7 g of atc per g of desu could be incorporated into a complex. the formation of desu/atc comp ...201526050890
soil warming and co2 enrichment induce biomass shifts in alpine tree line vegetation.responses of alpine tree line ecosystems to increasing atmospheric co2 concentrations and global warming are poorly understood. we used an experiment at the swiss tree line to investigate changes in vegetation biomass after 9 years of free air co2 enrichment (+200 ppm; 2001-2009) and 6 years of soil warming (+4 °c; 2007-2012). the study contained two key tree line species, larix decidua and pinus uncinata, both approximately 40 years old, growing in heath vegetation dominated by dwarf shrubs. in ...201525471674
[vaccinium myrtillus]. 201525702253
a comparison of fruit quality parameters of wild bilberry (vaccinium myrtillus l.) growing at different locations.as a part of the ongoing interest in nutritional and nutraceutical properties of locally produced fruits, the aim of the article was to determine sugars, organic acids, polyphenols and antioxidant capacity of wild bilberries grown in slovenia. primary and secondary metabolite composition of bilberry fruit was compared among six phyto-climatic conditions, differing in photosynthetic active radiation and light intensity.201525186189
highly selective separation and purification of anthocyanins from bilberry based on a macroporous polymeric adsorbent.powdered bilberry extract (united states pharmacopoeia, usp35-nf30), which is prepared from ripe bilberry fruits (vaccinium myrtillus l.), is the main ingredient of drugs alleviating visual fatigue and diabetic retinopathy because of the rich anthocyanins (purity of 36%). in this study, a method based on a macroporous polymeric adsorbent was established to obtain anthocyanin compounds from bilberry, in which the purity of the anthocyanins was improved to 96%, conducive to further pharmacological ...201525786117
vegetation shift from deciduous to evergreen dwarf shrubs in response to selective herbivory offsets carbon losses: evidence from 19 years of warming and simulated herbivory in the subarctic tundra.selective herbivory of palatable plant species provides a competitive advantage for unpalatable plant species, which often have slow growth rates and produce slowly decomposable litter. we hypothesized that through a shift in the vegetation community from palatable, deciduous dwarf shrubs to unpalatable, evergreen dwarf shrubs, selective herbivory may counteract the increased shrub abundance that is otherwise found in tundra ecosystems, in turn interacting with the responses of ecosystem carbon ...201525950664
characteristics of physico-chemical properties of bilberry (vaccinium myrtillus l.) jams with added herbs.low-sugar bilberry jams without added herbs and those with added mentha (1 %) and lemon balm (1 %) were examined for levels of selected physico-chemical indicators, antioxidant activity, colour and texture. jams were obtained by two methods: cooked in an open pan and cooked in a vacuum evaporator. 100 g fresh mass contained 0.076-0.481 mg hmf, 5.8-7.1 mg vitamin c, 176-232 mg total polyphenols, 122-156 mg total flavonoids, 73-96 mg total anthocyanins, with antioxidant activity per 1 g of 405-575 ...201525892779
application of pulsed electric field in the production of juice and extraction of bioactive compounds from blueberry fruits and their by-products.the influence of pulsed electric field (pef) pre-treatment of blueberry fruits (vaccinium myrtillus l.), both on the extraction yield and antioxidant properties of juice obtained by pressing and on the on the recovery of bioactive compounds from berry by-products (press cake) by extraction with solvent, was investigated. pef treatments carried out at field strengths of 1, 3, and 5 kv/cm and an energy input of 10 kj/kg achieved a cell disintegration index (z p ) of 0.70, 0.80, and 0.87, respectiv ...201526345006
anthocyanin profile in berries of wild and cultivated vaccinium spp. along altitudinal gradients in the alps.vaccinium spp. berries provide some of the best natural sources of anthocyanins. in the wild bilberry (vaccinium myrtillus l.), a clear increasing trend in anthocyanin biosynthesis has been reported toward northern latitudes of europe, but studies related to altitude have given contradictory results. the present study focused on the anthocyanin composition in wild bilberries and highbush blueberry (vaccinium corymbosum l. cv. brigitta blue) growing along altitudinal gradients in the alps of nort ...201526373665
influence of accelerated solvent extraction and ultrasound-assisted extraction on the anthocyanin profile of different vaccinium species in the context of statistical models for authentication.anthocyanins are frequently discussed as marker compounds for fruit product authenticity. proper analysis including sample preparation for the determination of anthocyanin concentrations is crucial for the comparability of authenticity data. the present study determined the influence of accelerated solvent extraction (ase) and ultrasound-assisted extraction (uae), using two different solvent compositions on the anthocyanin profile of bilberries (vaccinium myrtillus l.), lowbush blueberries (vacc ...201526330254
the potential of dark septate endophytes to form root symbioses with ectomycorrhizal and ericoid mycorrhizal middle european forest plants.the unresolved ecophysiological significance of dark septate endophytes (dse) may be in part due to existence of morphologically indistinguishable cryptic species in the most common phialocephala fortinii s. l.--acephala applanata species complex (pac). we inoculated three middle european forest plants (european blueberry, norway spruce and silver birch) with 16 strains of eight pac cryptic species and other dse and ectomycorrhizal/ericoid mycorrhizal fungi and focused on intraradical structures ...201525905493
inferring the origin of rare fruit distillates from compositional data using multivariate statistical analyses and the identification of new flavour constituents.in serbia, delicatessen fruit alcoholic drinks are produced from autochthonous fruit-bearing species such as cornelian cherry, blackberry, elderberry, wild strawberry, european wild apple, european blueberry and blackthorn fruits. there are no chemical data on many of these and herein we analysed volatile minor constituents of these rare fruit distillates. our second goal was to determine possible chemical markers of these distillates through a statistical/multivariate treatment of the herein ob ...201525043621
effects of vaccinium berries on serum lipids: a meta-analysis of randomized controlled trials.the beneficial effects of anthocyanins consumption on cardiovascular risk are supported by mechanistic and epidemiologic evidence. in order to explore the effects of vaccinium berries rich in anthocyanins on serum lipids, we conducted a meta-analysis of relevant randomized controlled trials (rcts). sixteen studies with 1109 subjects were included in this meta-analysis. significant heterogeneity confirmed differential effects between vaccinium subclasses. the whortleberry group is significantly s ...201526345230
genetic diversity and population structure of an important wild berry crop.the success of plant breeding in the coming years will be associated with access to new sources of variation, which will include landraces and wild relatives of crop species. in order to access the reservoir of favourable alleles within wild germplasm, knowledge about the genetic diversity and the population structure of wild species is needed. bilberry (vaccinium myrtillus) is one of the most important wild crops growing in the forests of northern european countries, noted for its nutritional p ...201526483325
fractionation of an anthocyanin-rich bilberry extract and in vitro antioxidative activity testing.the incidence of chronic diseases increases with advancing age of the population. a commonly discussed cause of chronic diseases is oxidative stress, which occurs in the body when there is an imbalance between the formation and inactivation of so-called reactive oxygen species (ros). epidemiological data suggest that a 'healthy diet', with a high content of flavonoids indicates preventive properties and correlates with an inverse effect with respect to the risk of chronic diseases. berries (espe ...201525149006
dwarf shrub hydraulics: two vaccinium species (vaccinium myrtillus, vaccinium vitis-idaea) of the european alps compared.vaccinium myrtillus and vaccinium vitis-idaea are two dwarf shrubs widespread in the european alps. we studied the hydraulics of these species hypothesizing that (1) the hydraulic architecture of dwarf shrubs differs from trees, (2) hydraulic properties reflect the species' ecological amplitude and (3) hydraulic properties vary spatially and seasonally. key hydraulic parameters (osmotic potential, turgor loss point, xylem hydraulic conductivity, vulnerability to drought-induced embolism, stomata ...201525677081
vaccinium myrtillus extract prevents or delays the onset of diabetes--induced blood-retinal barrier breakdown.many dietary supplements have been sold through advertising their large number of beneficial effects. the aim of this study was to determine whether bilberries (vaccinium myrtillus) help to prevent diabetes-induced retinal vascular dysfunction in vivo. v. myrtillus extract (vme; 100 mg/kg) was orally administered to streptozotocin-induced diabetic rats for 6 weeks. all diabetic rats exhibited hyperglycemia, and vme did not affect the blood glucose levels and body weight during the experiments. i ...201525582181
a cross-cultural comparison of folk plant uses among albanians, bosniaks, gorani and turks living in south kosovo.kosovo represents a unique hotspot of biological and cultural diversity in europe, which allows for interesting cross-cultural ethnobotanical studies. the aims of this study were twofold: 1) to document the state of traditional knowledge related to local (esp. wild) plant uses for food, medicine, and handicrafts in south kosovo; and 2) to examine how communities of different ethnic groups in the region (albanians, bosniaks/gorani, and turks) relate to and value wild botanical taxa in their ecosy ...201525964167
salinity-induced expression of hkt may be crucial for na(+) exclusion in the leaf blade of huckleberry (solanum scabrum mill.), but not of eggplant (solanum melongena l.).reduced na(+) accumulation in the leaf blade is an important aspect of salinity tolerance and high affinity k(+) transporters (hkts) are known to play a significant role in the process. huckleberry and eggplant have previously been shown to display 'excluder' and 'includer' characteristics, respectively, under salt stress, but the underlying mechanisms have not been investigated. here, we isolated the cdna of the hkt homologs, solanum scabrum hkt (sshkt) from huckleberry and solanum melongena hk ...201525796329
essential and non-essential elements in natural vegetation in southern norway: contribution from different sources.concentrations of essential and non-essential elements in five widespread species of natural boreal vegetation were studied with respect to seasonal variation and contribution from different sources. the plant species included in the study were betula pubescens, sorbus aucuparia, vaccinium myrtillus, vaccinium uliginosum, calluna vulgaris and deschampsia flexuosa. concentrations of elements essential to plants remained essentially constant or decreased slightly throughout the growing season. con ...201525268568
a "clearcut" case? brown bear selection of coarse woody debris and carpenter ants on clearcuts.forest management alters habitat characteristics, resulting in various effects among and within species. it is crucial to understand how habitat alteration through forest management (e.g. clearcutting) affects animal populations, particularly with unknown future conditions (e.g. climate change). in sweden, brown bears (ursus arctos) forage on carpenter ants (camponotus herculeanus) during summer, and may select for this food source within clearcuts. to assess carpenter ant occurrence and brown b ...201526190890
pollinator behaviour on a food-deceptive orchid calypso bulbosa and coflowering species.food deception as a pollination strategy has inspired many studies over the last few decades. pollinator deception has evolved in many orchids possibly to enhance outcrossing. food-deceptive orchids usually have low pollinator visitation rates as compared to rewarding species. they may benefit in visitations from the presence (magnet-species hypothesis) or, alternatively, absence of coflowering rewarding species (competition hypothesis). we present data on pollinator visitations on a deceptive, ...201525861675
biological availability of (238)u, (234)u and (226)ra for wild berries and meadow grasses in natural ecosystems of belarus.this work is devoted to investigation of behavior of (234)u, (238)u and (226)ra by determining the soil to plant transfer under different natural conditions such as forest or swamped areas and meadow lands with different soil types. the paper summarizes the data on investigation of uranium and radium uptake by wild berries and natural meadow grasses in the typical conditions of belarus. parameters characterizing the biological availability of (234)u, (238)u and (226)ra for bilberry (vaccinium my ...201423871250
promising results of cranberry in the prevention of oral candida biofilms.in the context of dental caries prevention by natural foodstuff sources, antifungal and antibiofilm activities of dry commercial extracts of cranberry fruit (vaccinium macrocarpon aiton) and two other red fruits (vaccinium myrtillus l. and malpighia punicifolia l.) were assessed on candida albicans and candida glabrata yeasts. when added to the culture medium, the cranberry extract displayed a significant anti-adhesion activity against candida spp. when used at low concentrations. in addition, t ...201424623607
anti-inflammatory effects of anthocyanins-rich extract from bilberry (vaccinium myrtillus l.) on croton oil-induced ear edema and propionibacterium acnes plus lps-induced liver damage in mice.bilberry (vaccinium myrtillus l.) has been known to play a protective role in human health due to its high anthocyanin content. this study investigated the anti-inflammatory effects of bilberry extract (be, containing 42.04% anthocyanin) on propionibacterium acnes (p. acnes) plus lipopolysaccharide (lps) induced liver injury and croton oil-induced ear edema in mice. results showed that be could effectively inhibit croton oil-induced ear edema and liver inflammation provoked by p. acnes plus lps, ...201424548119
effect of plant extracts on h2o2-induced inflammatory gene expression in macrophages.arctium lappa (al), camellia sinensis (cs), echinacea angustifolia, eleutherococcus senticosus, panax ginseng (pg), and vaccinium myrtillus (vm) are plants traditionally used in many herbal formulations for the treatment of various conditions. although they are well known and already studied for their anti-inflammatory properties, their effects on h2o2-stimulated macrophages are a novel area of study.201425075197
monochromatic light increases anthocyanin content during fruit development in bilberry.light is one of the most significant environmental factors affecting to the accumulation of flavonoids in fruits. the composition of the light spectrum has been shown to affect the production of phenolic compounds during fruit ripening. however, specific information on the biosynthesis of flavonoids in fruits in response to different wavelengths of light is still scarce. in the present study bilberry (vaccinium myrtillus l.) fruits, which are known to be rich with anthocyanin compounds, were ill ...201425511869
health effects of vaccinium myrtillus l.: evaluation of efficacy and technological strategies for preservation of active ingredients.bilberries are a rich dietary source of various phytonutrients, including anthocyanins which contribute greatly to their antioxidant capacity and have demonstrated a broad spectrum of biomedical functions. these include protection against cardiovascular disorders, age-induced oxidative stress, inflammatory responses and several degenerative diseases. berry anthocyanins also improve neuronal and cognitive brain functions, ocular health as well as protecting genomic dna integrity. in recent years, ...201425052033
variability of procyanidin type a- and -b trimers content in aerial parts of some vaccinium species and cultivars.based on the ethnopharmacological data showing that either wild bilberry leaves or whole aerial parts of the plants have been used as antidiabetic drugs, it can be hypothesized that the controversial results of various clinical and animal investigations may be caused by different contents of the active principles in different aerial parts of the bilberry/blueberry (vaccinium spp.) plants, as well as by their geographical and seasonal variability. the aim of this study was to compare the content ...201425115086
distinguishing vaccinium species by chemical fingerprinting based on nmr spectra, validated with spectra collected in different laboratories.a method was developed to distinguish vaccinium species based on leaf extracts using nuclear magnetic resonance spectroscopy. reference spectra were measured on leaf extracts from several species, including lowbush blueberry (vaccinium angustifolium), oval leaf huckleberry (vaccinium ovalifolium), and cranberry (vaccinium macrocarpon). using principal component analysis, these leaf extracts were resolved in the scores plot. analysis of variance statistical tests demonstrated that the three group ...201424963620
wild blueberries (vaccinium myrtillus) alleviate inflammation and hypertension associated with developing obesity in mice fed with a high-fat diet.low-grade metabolic inflammation and hypertension are primary mechanisms involved in obesity-associated adverse health effects. berries, especially nordic wild blueberries (hereafter referred to as bilberries), represent an important source of dietary anthocyanins, a group of polyphenols with potential beneficial effects to combat obesity-associated metabolic disturbances.201425501421
vaccinium myrtillus leaves and frangula alnus bark derived extracts as potential antistaphylococcal agents.due to constantly increasing antibiotic resistance of pathogens and participation of the biofilms they make in various types of infections, a development of alternative therapeutic strategies becomes an urgent need. taking advantage of the biological activity of plant-derived compounds can solve this problem. in this study antimicrobial, including those synergistic with classic antibiotics, and cytotoxic properties of newly-obtained extracts from vaccinium myrtillus leaves (vle) and frangula aln ...201424649485
protective effect of vaccinium myrtillus extract against uva- and uvb-induced damage in a human keratinocyte cell line (hacat cells).recently, the field of skin protection have shown a considerable interest in the use of botanicals. vaccinium myrtillus contains several polyphenols and anthocyanins with multiple pharmacological properties. the purpose of our study was to examine whether a water-soluble v. myrtillus extract (dry matter 12.4%; total polyphenols 339.3mg/100 g fw; total anthocyanins 297.4 mg/100 g fw) was able to reduce uva- and uvb-induced damage using a human keratinocyte cell line (hacat). hacat cells were pret ...201424577051
protective effects of bilberry and lingonberry extracts against blue light-emitting diode light-induced retinal photoreceptor cell damage in vitro.blue light is a high-energy or short-wavelength visible light, which induces retinal diseases such as age-related macular degeneration and retinitis pigmentosa. bilberry (vaccinium myrtillus l.) and lingonberry (vaccinium vitis-idaea) contain high amounts of polyphenols (anthocyanins, resveratrol, and proanthocyanidins) and thus confer health benefits. this study aimed to determine the protective effects and mechanism of action of bilberry extract (b-ext) and lingonberry extract (l-ext) and thei ...201424690313
is the antioxidative effectiveness of a bilberry extract influenced by encapsulation?bilberries (vaccinium myrtillus l.) have been suggested to have preventive properties against diseases associated with oxidative stress such as colon cancer or inflammatory bowel diseases. therefore the gastrointestinal tract is regarded as a potential target for prevention. in this study the antioxidative properties of a commercially available anthocyanin-rich bilberry extract (be) were investigated in comparison with four different be-loaded microcapsule systems. as markers to describe the ant ...201424395460
increased spring freezing vulnerability for alpine shrubs under early snowmelt.alpine dwarf shrub communities are phenologically linked with snowmelt timing, so early spring exposure may increase risk of freezing damage during early development, and consequently reduce seasonal growth. we examined whether environmental factors (duration of snow cover, elevation) influenced size and the vulnerability of shrubs to spring freezing along elevational gradients and snow microhabitats by modelling the past frequency of spring freezing events. we sampled biomass and measured the s ...201424435708
characterization of metabolite profiles of leaves of bilberry (vaccinium myrtillus l.) and lingonberry (vaccinium vitis-idaea l.).leaves of bilberry (vaccinium myrtillus l.) and lingonberry (vaccinium vitis-idaea l.) are potential raw materials for food and health care products. targeted (hplc-dad, hplc-ms, and gc-fid) and nontargeted ((1)h nmr) approaches were applied to study the metabolomic profiles of these leaves. chlorogenic acid was the major phenolic compound in bilberry leaves and arbutin in lingonberry leaves. flavonol glycosides were another major group of phenolics in bilberry [5-28 mg/g dm (dry mass)] and ling ...201425408277
bilberry adulteration: identification and chemical profiling of anthocyanins by different analytical methods.extracts of the bilberry fruit have protective effects against retinopathy and vascular complications; therefore, they are important ingredients in food supplements. recently, there have been several reported cases of adulteration. thus, to characterize the anthocyanin profile, and the relative percentages of these pigments, this study analyzed bilberry fruits from different countries by liquid chromatography coupled to a diode array detector and a mass spectrometer detector. a total of 15 antho ...201425365784
pharmacopeial hplc identification methods are not sufficient to detect adulterations in commercial bilberry (vaccinium myrtillus) extracts. anthocyanin profile provides additional clues.current pharmacopeias provide hplc anthocyanin profiles to identify commercial bilberry extracts. however, the pharmacopeial identification protocols may not be sufficient enough to distinguish genuine bilberry extracts from adulterated material. this is primarily due to the non-inclusion of literature-reported anthocyanin profile and compositional variations in bilberry when sourced from different geographical regions. using anthocyanin profiles of both authentic bilberry extracts and literatur ...201425250894
a cosmeceutical formulation based on boswellic acids for the treatment of erythematous eczema and psoriasis.boswellic acids (bas) show anti-inflammatory properties in a variety of inflammatory diseases, including rheumatoid arthritis, osteoarthritis, and asthma. a topical administration route is currently used to deliver active compounds in psoriatic and eczematous patients. in this double-blind study we compare a novel ba formulation (containing bosexil(®), inci [international nomenclature of cosmetic ingredients]: lecithin, boswellia serrata resin extract) with a placebo formulation. a third arm of ...201425419153
improved lipid profile in hyperlipidemic patients taking vaccinium arctostaphylos fruit hydroalcoholic extract: a randomized double-blind placebo-controlled clinical trial.dyslipidemia is a common contributory cause of cardiovascular disease. vaccinium arctostaphylos l. (caucasian whortleberry) fruit is rich of anthocyanins. anthocyanins may exert cardioprotective effects by various mechanisms such as favorably modulating dyslipidemia. therefore, in this randomized double-blind placebo-controlled clinical trial with hyperlipidemic (hypercholesterolemic and/or hypertriglyceridemic) patients aged 20-60 years, the effects of taking a standardized whortleberry fruit h ...201423686894
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