Publications

cysteine biosynthesis in aspergillus nidulans.	the existence of two postulated pathways of anabolic cysteine biosynthesis in aspergillus midulans was investigated. no activities of the postulated pathway involving s-sulfocysteine as intermediate have been detected. investigations on cyteine and methionine requiring mutants revealed independent regulation of o-acetylserine sulfhydrylase by endogeneous cysteine and methionine pools. the reaction catalysed by o-acetylserine sulfhydrylase is postulated as the only anabolic pathway of cysteine bi ...	1975	1108603
genetic control of chromosome instability in aspergillus nidulans as a mean for gene amplification in eukaryotic microorganisms.	a haploid strain of aspergillus nidulans carrying i-ii duplication homozygous for the leaky mutation ade20 shows impreved growth on minimal medium. the duplication, though more stable than disomics, still shows instability. several methods were used for detecting genetic control of improved stability. (a) visual selection, using a duplicated strain which is very unstable due to uv sensitivity, (ade20, bial/dp ya2; uvsb). one stable strain showed a deletion (or a lethal mutation?) distal to bia o ...	1975	1107799
the inheritance of penicillin titre in crosses between lines of aspergillus nidulans selected for increased productivity.	selection for increased penicillin production among the progeny of pairwise crosses between wild-type isolates of aspergillus nidulans resulted in the production of high-titre strains. three crosses were made between strains with increased titre derived from independent selection lines. significant genetic variation was found among the progeny of each cross, indicating that different genes for increased titre had been selected in each line. gene action was additive in each cross. renewed selecti ...	1975	1107475
hybridization and selection for increased penicillin titre in wile-type isolates of aspergillus nidulans.	repeated hybridization and selection among wild-type isolates produced strains of aspergillus nidulans with increased penicillin titre. four independent selection lines were established, each originating from a sexual cross between two different heterokaryon-incompatible wild-type isolates. in each generation, two selected high-titre sister strains were crossed to produce the next generation. an initial increase in titre was obtained in each line, but after four or five generations of selection ...	1975	1107474
hybridization and selection for increased penicillin titre in wild-type isolates of aspergillus nidulans.	repeated hybridization and selection among wild-type isolates produced strains of aspergillus nidulans with increased penicillin titre. four independent selection lines were established, each originating from a sexual cross between two different heterokaryon-incompatible wild-type isolates. in each generation, two selected high-titre sister strains were crossed to produce the next generation. an initial increase in titre was obtained in each line, but after four or five generations of selection ...	1975	1107473
cytochrome abnormalities and cyanide-resistant respiration in extranuclear mutants of aspergillus nidulans.	the cytochrome spectra of two extranuclear mutants of aspergillus nidulans and the double-mutant recombinant formed from them have been examined both at room temperature and at the temperature of liquid n2 and compared with those of the wild-type strain. the oligomycin-resistant, slow growing mutant contained an increased amount of cytochrome c without any loss of cytochromes b and a,a3. the cold-sensitive mutant, apparently normal when grown at 37 c, showed an increased amount of cytochrome c a ...	1976	1107321
formation of 2,4-dihydroxybenzoic acid & resorcinol as intermediates in the degradation of salicylic acid by aspergillus nidulans.		1975	1107218
sexual differentiation in aspergillus nidulans: the requirement for manganese and its effect on alpha-1,3 glucan synthesis and degradation.	aspergillus nidulans was grown on media with added amounts of manganese ranging from 0--2.5 mum. manganese deficiency prevented cleistothecium development, although good vegetative growth was retained. subsequent analysis of the mycelium produced under mn2+ deficient growth revealed that alpha-1,3 glucan, the man carbon and energy source for fructification, was virtually absent from the cell wall. several enzymes related to cell wall composition were investigated. beta-1,3 glucanase, and very re ...	1975	1106342
studies of partially repressed mutants at the tama and area loci in aspergillus nidulans.	mutants, designated tamar, have been isolated on the basis of simultaneous resistance to toxic analogues thiourea, aspartate hydroxamate and chlorate with l-alanine as the sole nitrogen source. tamar mutants are also resistant to methylammonium. this resistance of tamar mutants is correlated with partially repressed activity of a number of enzyme and transport systems regulated by ammonium. furthermore, tam-ar mutants have low nadp-glutamate dehydrogenase (nadp-gdh) activity and also efflux ammo ...	1975	1105154
amide utilization in aspergillus nidulans: evidence for a third amidase enzyme.	a mutation in a gene designated gmda has been found to lead to loss of ability of aspergillus nidulans to use benzamide, phenylacetamide and several other amides as sole nitrogen sources for growth. the gmda1 lesion results in low levels of an enzyme, called the general amidase, which has acitivity for a wide range of amide substrates. this enzyme is reressed by certain nitrogen-containing metabolites, including ammonium, but is probably not regulated by induction or by carbon catabolite repress ...	1975	1104771
proceedings: fungicides causing mitotic segregation in aspergillus diploids.		1975	1102965
pyrimidine biosynthesis in aspergillus nidulans: isolation and preliminary characterisation of auxotrophic mutants.	113 pyrimidine auxotrophs, unable to synthesise ump have been selected in aspergillus nidulans. these mutants can be classified by complementation into eight groups, and genetic analysis has shown that five loci are involved. one complex locus consists of the mutually complementing pyra, pyrb and pyrc groups, as well as the cis-dominant pyrn group, members of which do not complement with members of the a, b or c groups. pyra mutants have been shown to lack cpsase-ur, pyrb and pyrc mutants have b ...	1975	1102932
cytoplasmic and nuclear mutations to chloramphenicol resistance in aspergillus nidulans.	two chloramphenicol resistance mutations out of 123 tested in aspergillus nidulans are inherited extranuclearly as judged by transmissibility in heterokaryons, lack of segregation at meiosis, and independent segregation from all of the eight nuclear linkage groups. they do not recombine with each other. however, experiments in collaboration with g. turner and r.t. rowlands show that they do recombine with cytoplasmic mutations to oligomycin resistance (rowlands and turner, 1973) and cold-sensiti ...	1975	1102919
mutations affecting mitotic recombination frequency in haploids and diploids of the filamentous fungus aspergillus nidulans.	a haploid strain of asp. nidulans with a chromosome segment in duplicate (one in normal position on chromosome i, one translocated to chromosome ii) shows mitotic recombination, mostly by conversion, in ade in a frequency slightly higher than in the equivalent diploid. a method has been devised, using this duplication, for the selection of rec and uvs mutations. six rec mutations have been found which decrease recombination frequency in the haploid. one mutation selected as uv sensitive showed a ...	1975	1102911
enzymatic lesions in methionine mutants of aspergillus nidulans: role and regulation of an alternative pathway for cysteine and methionine synthesis.	in aspergillus nidulans the pathway involving cystathionine formation is the main one for homocysteine synthesis. mutants lacking cystathionine gamma-synthase or beta-cystathionase are auxotrophs suppressible by: (i) mutations in the main pathway of cysteine synthesis (cysa1, cysb1, and cysc1), (ii) mutations causing stimulation of cysteine catabolism (su101), and (iii) mutations in a presumed regulatory gene (suameth). a relative shortage of cysteine in the first group of suppressors causes a d ...	1975	1102536
an easy way of obtaining aspergillus nidulans haploids in the parasexual cycle using n-glycosyl polifungin.		1975	1102390
mutants affecting histidine utilization in aspergillus nidulans.		1975	1102388
homolanthionine in fungi: accumulation in the methionine-requiring mutants of aspergillus nidulans.	homolanthionine, a higher homologue of cystathionine, was found to accumulate in the mutants of aspergillus nidulan impaired in the synthesis of methionine from homocysteine. the additional introduction of mutation resulting in a block at cystathionine gamma-synthase but not at cystathionine beta-synthase abolishes accumulation of both homolanthionine and cystathionine. this suggests a possible participation of cystathionine gamma-synthase in homolanthionine synthesis.	1975	1101592
quantitative tissue invasion of the murine brain as a phenotypic marker of strain virulence in aspergillus nidulans.	in this study the extent of fungal invasion in tissues of the target organs (brain, heart and kidney) has been quantitated histologically in dba/2j mice inoculated intravenously with 3 strains of aspergillus nidulans of different virulence. this was done to determine the relation between tissue invasion and strain virulence as determined by time-mortality bioassay. it was found that quantitatively tissue invasion by a. nidulans was target organ specific. relative tissue invasion within each of t ...	1975	1099700
the effect of chloral hydrate upon mitosis in aspergillus nidulans.		1975	1097582
nitrate utilization and growth in biotin-deficient aspergillus nidulans.	a marked increase in the cellular synthesis accompanied by a decrease in the total fatty acid content was observed when aspergillus nidulans was grown on nh4no3 as a sole nitrogen source, in the medium containing avidin. because of the increased uptake of nh4(plus), the level of nh4(plus), was lowered in the medium; as a result there is early uptake and assimilation of nitrate by a biotin-deficient culture as compared with the normal culture of a. nidulans. at about 17mm concentration, nh4(plus) ...	1975	1097067
effect of l-histidine on the catabolism of nitrogenous compounds in aspergillus nidulans.		1975	1094095
reciprocal translocations and translocation disomics of aspergillus and their use for genetic mapping.	two new techniques are described for genetic mapping of reciprocal translocations in a. nidulans, which can be used to locate centromeres and meiotically unlinked markers. they both make use of unbalanced disomics from heterozygous translocation crosses. these are mainly hyperhaploids of two classes: either typical-looking n + 1 with a normal chromosome in addition to a haploid set containing the translocation, or translocation disomics. when large chromosome segments are involved, such disomics ...	1975	1092596
keratomycosis in lucknow.		1975	1092323
autolytic enzymes in hyphae of aspergillus nidulans: their action on old and newly formed walls.	walls, purified from hyphae of the ascomycete aspergillus nidulans, autolyzed on incubation and liberated glucose, mannose, galactose, n-acetylglucosamine, and soluble oligosaccharides. digestion proceeded at linear rates until approximately 3% of the wall polymers had been hydrolyzed and then slowed markedly. the change in the rate of autolysis was not due to loss of enzyme activity but was caused by the disappearance of a fraction of the wall which was highly susceptible to digestion. radioact ...	1975	1090573
initiator constitutive mutation with an 'up-promoter' effect in aspergillus nidulans.	a mutation leading to strong constitutivity for a uric acid-xanthine permease in the lower eukaryote aspergillus nidulans has been found to be tightly linked to the putative structural gene whose expression it controls in the cis configuration. in addition, it increases the maximal induced level of transport 2.5-fold. this is the first demonstration of an initiator or promoter mutation in an eukaryote.	1975	1089904
a gene cluster in aspergillus nidulans with an internally located cis-acting regulatory region.	work reported here on the fungus aspergillus nidulans has provided the first definitive demonstration of operon-type organisation in an eukaryote genome. it has been shown that the prna and prnb genes concerned with proline metabolism form a gene cluster with the regulatory region lying between the two putative structural genes prna and prnb. regulatory mutations (prnd) probably leading to relief of carbon catabolite repression, map in between prna and prnb and are cis-dominant with respect to b ...	1975	1089903
mutations which affect amino acid transport in aspergillus nidulans.	mutants deficient in amino acid transport (aau), and unable to utilize l-glutamate as a sole carbon and nitrogen source, have been isolated. there are four unlinked genes involved: aaua, aaub, aauc and aaud. the transport levels of certain amino acids, and the growth characteristics on certain nitrogen and carbon sources and toxic amino acid analogues, indicate that: aauai has defective transport of acidic amino acids; aaubi has defective transport of acidic and neutral amino acids; aauci and aa ...	1975	1089752
glucose uptake by aspergillus nidulans, purification and properties of glucose binding protein.		1975	1089548
increased fusion frequency of aspergillus nidulans protoplasts.		1975	1089544
a cis-dominant regulatory mutation affecting enzyme induction in the eukaryote aspergillus nidulans.		1975	1089206
role of nicotinic acid in pyridoxine biosynthesis in aspergillus nidulans.		1976	999690
[action of various beta(1-3)-d-glucanases on the wall of yeasts: taxonomic applications].	purified beta-(1-3)-d-glucanases (from aspergillus nidulans, badidiomycetes sp. qm 806, trichoderma viride) are used to release protoplasts from various yeasts. two of them may prove taxonomic correlation. the enzyme of basidomycetes sp. releases protoplasts from ascomycetes, the enzyme of t. viride releases protoplasts from ascomycetes and heterobasidiomycetes; none of them acts on the basidiomycetes.	1976	826331
genetics of biosynthesis and overproduction of penicillin.		1976	823642
functional 70s hybrid ribosomes from blue-green algae and bacteria.	hybrid 70s ribosomes were produced by combing anacystis nidulans and escherichia coli 30s and 50s subunits. both the a. nidulans 30se. coli 50s and e. coli 30s- a. nidulans 50s hybrids were functional in synthesizing protein when tested in a standard in vitro amino acid incorporating system. both 70s hybrids were inhibited by streptomycin but the degree of inhibition was dependent upon the source of the 30s subunit. the ability to form functional 70s ribosomes from subunits of blue-green algae a ...	1976	822798
isolation and characterization of a cyanophage infecting the unicellular blue-green algae a. nidulans and s. cedrorum.		1976	821247
[a genetic transfer system in a cyanophyte of the genus aphanocapsa].	the possibility of a genetic transfer, through a process of transformation, has been shown in a unicellular, facultative chemoheterotroph blue-green algae, aphanocapsa 6714. similarly to the process described with anacystis nidulans, the recipient strain becomes competent when the growth reaches its second, slower, exponential phase. the genetic marker conferring resistance to p-f-phenylalanine has been transferred with a frequency 20 to 100 times higher than that of the spontaneous mutations. t ...	1976	817846
counterimmunoelectrophoresis in the diagnosis of mycetoma and its sensitivity as compared to immunodiffusion.	counterimmunoelectrophoresis used for the diagnosis of mycetoma was found superior to immunodiffusion (id) especially when using neat serum and 1:2 dilution (p=less than 0.0001 with neat serum; and less than 0.01 with 1:2 dilution). it is recommended for routine use in mycology laboratories for following up patients on treatment and for confirming the diagnosis of sera that are weakly positive by id.	1975	817400
the reconstitution of anacystis nidulans dna-dependent rna polymerase from its isolated subunits.	the dna-dependent rna polymerase of the blud-green alga anacystis nidulans was reconstituted from its isolated subunits in the absence of urea. applying this technique the kinetics and the subunit requirements of the reconstitution process were analyzed. the results reveal differences with respect to the reconstitution of escherichia coli polymerase. reconstitution proceeds much more slowly in the case of the a. nidulans enzyme. reconstitution here is absolutely dependent on the presence of the ...	1976	814000
hemolytic, cytotoxic and complement inactivating properties of extracts of different species of aspergillus.	some of the biological properties of saline extracts of the mycelia of several species of the aspergillus genus, namely, a. fumigatus, a. flavus, a. niger, a. nidulans, a. parasitucus and a. glaucus, were studied. only the extract prepared from a. fumigatus was found to be hemolytic for sheep red blood cells. in contrast, all the extracts with the only exception of that of a. glaucus, had cytotoxic effects on vero cells. both, the hemolytic and cytotoxic constituents of the extracts were removab ...	1975	813147
sequence studies on 16s ribosomal rna from a blue-green alga.	the 16s ribosomal rna of the blue green alga anacystis nidulans has been characterized in terms of the oligomers generated by digestion with t1 ribonuclease. a. nidulans by this criterion is definitely a procaryote; being no more distant from bacilli or enterics than the latter two are from one another. a. nidulans appears to be somewhat more closely related to the bacilli than to the enterics.	1975	813006
labeling the deoxyribonucleic acid of anacystis nidulans.	analysis of cell-free extracts of anacystis nidulans disclosed the absence of both thymidine phosphorylase (ec 2.4.2.4) and thymidine kinase (ec 2.7.1.21) activities. thymine and thymidine were incorporated inefficiently by intact cells of a. nidulans either in the presence or absence of deoxyguanosine (250 mug/ml). deoxythymidine monophosphate incorporation was also inefficient. radioactive deoxyadenosine, at a minimally toxic level (3 mug/ml), was incorporated effectively into the deoxyribonuc ...	1975	809413
the fine structure of the branched alpha-d-glucan from the blue-green alga anacystis nidulans: comparison with other bacterial glycogens and phytoglycogen.	the fine structure of the glycogen from the blue-green alga anacystis nidulans has been examined. after selective hydrolysis of all (1 yields 6)-alpha-d linkages by a bacterial isoamylase, the resulting mixture of linear chains was subjected to gel permeation chromatography. for purposes of comparison, the glycogens from escherichia coli and arthrobacter sp., amylopectin, phytoglycogen from sweet corn, and shell-fish glycogen were treated similarly. the profiles of the unit chains of a nidulans ...	1975	806344
the design of fermentation and biological assay procedures for assessment of penicillin production in populations of aspergillus nidulans.		1975	805120
the inheritance of penicillin titre in wild-type isolates of aspergillus nidulans.	in a sample of 52 wild-type isolates of aspergillus nidulans, penicillin titre ranged from 0-0 to 14-4 units/ml. these differences in titre were under genetic control. most of the variation between isolates was attributable to differences between heterokaryon-compatibility groups although significant differences were also found within groups. genetic variation for penicillin titre was observed among the progeny in four of seven crosses between wild-type isolates. in these four crosses the variat ...	1975	803549
maternal inheritance of extranuclear mitochondrial markers in aspergillus nidulans.		1976	800001
choline-o-sulphate utilization in aspergillus nidulans.		1976	800000
presence of histones in aspergillus nidulans.	five major histone proteins have been extracted from chromatin isolated from purified nuclei of the fungus, aspergillus nidulans. these proteins had chromatographic properties which were similar to reference calf thymus histones and were purified to electrophoretic homegeneity by gel chromatography of bio-gel p10, bio-gel p60, and sephadex g-100. electrophoresis of these proteins in three different systems (urea-starch, urea-acetic acid polyacrylamide, and discontinuous sds polyacrylamide) showe ...	1976	799641
the effects of putrescine, spermidine, and spermine on the growth of a polyamine-requiring mutant of aspergillus nidulans.		1976	798706
synthesis of polyamines in the germinating conidia of aspergillus nidulans.		1976	798705
panel discussion on submammalian systems.		1976	796705
formation of nadph-nitrate reductase activity in vitro from aspergillus nidulans niad and cnx mutants.	mutants of a. nidulans at several loci lack detectable nadph-nitrate reductase activity. these loci include niad, the structural gene for the nitrate reductase polypeptide, and five other loci termed cnxabc, e, f, g and h which are presumed to be involved in the formation of a molybdenum-containing component (mcc) necessary for nitrate reductase activity. when forzen mycelia from a. nidulans deletion mutant niad26 were homogenized in a ten broeck homogenizer together with frozen mycelia from eit ...	1976	796678
mitosis, septation, branching and the duplication cycle in aspergillus nidulans.	mitosis, septation and branching were studied in undifferentiated mycelia and leading hyphae of aspergillus nidulans, a mould which forms incomplete septa. after spore germination, nuclei divided synchronously until germ-tube hyphae contained 8 or 16 nuclei; mitosis occurred when the volume of cytoplasm per haploid nucleus was about 60 mum3. intercompartment development was not synchronized, consequently mitosis in the mycelium as a whole eventually became asynchronous. during the stage of async ...	1976	796408
purification of a deoxyribonuclease from aspergillus nidulans.		1976	793906
estimation of the generation time and peripheral growth zone of aspergillus nidulans and alternaria solani hyphae from radial growth rates and ranges in apical cell length.		1976	792392
relationship of the genetic determination of impaired penicillin production in naturally occurring strains to that in induced mutants of aspergillus nidulans.		1976	792389
phosphorus uptake in biotin deficient aspergillus nidulans: an evidence for the involvement of binding protein in this process.		1976	791857
[dna degradation induced by radiation in aspergillus nidulans].		1976	791383
polyamine and ornithine metabolism during the germination of conidia of aspergillus nidulans.	1. the activities of ornithine decarboxylase, s-adenosylmethionine decarboxylase and ornithine-2-oxoglutarate aminotransferase were studied during the first 24 h of conidial germination in aspergillus nidulans. 2. increases (over 100-fold) in the activities of ornithine decarboxylase and s-adenosylmethionine decarboxylase occurred during the emergence of the germ-tube and before the doubling of dna and this was followed by a sharp fall in the activities of both enzymes by 16h. 3. the increase in ...	1976	791270
the use of analytical electron microscopy in the study of three species of aspergillaceae.	the combination of electron beam scanning and x-ray detection allows to use the scanning electron probe microanalyzer as a sensitive microscope to elemental constitution. this made it possible to investigate three species of the aspergillus nidulans group: a. nidulans, a. unguis, a. variecolor. qualitative differences were found between the three species. the application of microanalysis is regarded as a useful addition to more conventional methods used in histochemical studies. the advantages o ...	1975	787898
the genetic instability and mutagenic interaction of chromosomal duplications present together in haploid strains of aspergillus nidulans.	previous work has shown that strains of aspergillus nidulans with a chromosome segment in duplicate (one in normal position, one translocated to another chromosome) are unstable. deletions occur from either duplicate segment. the present work has shown that when a chromosome i duplication and a chromosome iii duplication are together in a haploid, deletions from the intact iii duplication generally precede deletions from particular sections of the i duplication. furthermore, the iii duplication ...	1976	787776
fungal infections after renal transplantation.	fungal infections occurred in 3 of 22 renal transplants (13.6%). two patients developed rhinocerebral phycomycosis, and rhizopus arrhizus was isolated from cultures of the nasal conchae. both patients were treated with systemic amphotericin b. three-and-a-half months after transplantation the third patient developed an acute ureteral obstruction secondary to infection with aspergillus nidulans; this necessitated removal of the graft. there was no immediate mortality associated with these fungal ...	1976	786944
chloral hydrate induced haploidization in aspergillus nidulans.	this is the first report of induction of haploidization in aspergillus nidulans by chloral hydrate, which is an efficient polyploidizing agent for higher plants and a psychotropic drug for man. a new procedure has been described to isolate haploids from diploids with a very high frequency, as compared to p-fluorophenylalanine, which is generally used for this purpose.	1976	786720
[thermosensitive lethal mutants in aspergillus nidulans].		1975	785156
nucleosome structure in aspergillus nidulans.	the structure of chromatin from aspergillus nidulans was studied using micrococcal nuclease and dnaase i. limited digestion with micrococcal nuclease revealed a nucleosomal repeat of 154 base pairs for aspergillus and 198 base pairs for rat liver. with more extensive digestion, both types of chromatin gave a similar quasi-limit product with a prominent fragment at 140 base pairs. the similarity of the two limit digests suggests that the structure of the 140 base pair nucleosome core is conserved ...	1976	782724
partial purification of methionine binding protein from aspergillus nidulans by affinity chromatography.		1976	782531
proceedings: influence of microwaves on genetical processes of aspergillius nidulans.		1976	781259
enhancement of tissue invasion in murine aspergillosis by systemic administration of suspensions of killed corynebacterium parvum.	the effect of killed corynebacterium parvum vaccine on the course of murine aspergillosis is described. a grid-counting technique was employed to quantitate tissue invasion by aspergillus nidulans in the brain, heart, and kidneys (the target organs) of normal mice and of mice treated systemically with killed c. parvum vaccine. simultaneous treatment of mice with c. parvum and a. nidulans significantly increased the mortality rate, in contrast to treatment of mice with c. parvum prior to or follo ...	1976	779492
integrator gene in aspergillus nidulans.		1976	778641
agar as a carbon source and its effect on the utilization of other carbon sources by acetate non-utilizing (acu) mutants of aspergillus nidulans.		1976	778333
effect of glucose, ammonium and media maintenance on the time of conidiophore initiation by surface colonies of aspergillus nidulans.		1976	778332
the isolation of nuclei from the filamentous fungus aspergillus nidulans.	a method has been developed for isolating nuclei from the filamentous fungus aspergillus nidulans. in this procedure, the mycelia from 14 to 16 h spore-derived cultures of a. nidulans nri, a stable diploid strain, were frozen with liquid nitrogen and homogenized in a waring blender. after homogenization, the mycelia were warmed to 4 degrees c and the nuclei were purified from the homogenate by differential centrifugation followed by sedimentation through 2.1 m-sucrose. the final nuclear yield wa ...	1976	778331
mutants of aspergillus nidulans lacking pyruvate kinase.		1976	776698
well-marked strains of aspergillus for tests of environmental mutagens: identification of induced mitotic recombination and mutation.		1976	775325
cholorate toxicity in aspergillus nidulans: the selection and characterisation of chlorate resistant mutants.	mutation in at least ten genes can result in chlorate reistance in aspergillus nidulans. mutation in seven of these genes also results in the inability to use nitrate as nitrogen source. the various classes of resistant mutant obtained occur in different proportions, depending on whether or not a mutagenic treatment is employed, and also on which nitrogen source is used for selection. the prinicipal effect of mutagen arises because mutations in the niad gene, the nitrate reductase structural gen ...	1976	773908
mitotic mutants of aspergillus nidulans.		1975	773766
mitotic crossing over and nondisjunction in translocation heterozygotes of aspergillus.	to analyze mitotic recombination in translocation heterozygotes of a. nidulans two sets of well-marked diploids were constructed, homo- or heterozygous for the reciprocal translocations t1 (il;viir) or t2 (il;viir) and heterozygous for selective markers on il. it was found that from all translocation heterozygotes some of the expected mitotic crossover types could be selected. such crossovers are monosomic for one translocated segment and trisomic for the other and recovery depends on the relati ...	1976	773747
ornithine decarboxylase activity in germinating conidia of aspergillus nidulans.		1975	773695
subcellular mislocation of cysteine synthase in a cysteine auxotroph of aspergillus nidulans.		1975	773683
mitochondrial dna from aspergillus nidulans.		1975	773682
acquired resistance to benzimidazole derivatives.		1975	773644
tubulin-like protein from aspergillus nidulans.		1976	773373
determination of the execution points of mutations in the nuclear replication cycle of aspergillus nidulans.	cultures of nuclear replication cycle mutants of aspergillus nidulans were transferred to the nonpermissive temperature, and the fraction of nuclei still able to reach mitosis was determined. for the determinations, benomyl [methyl-1(butylcarbomoyl)benzimidazolecarbamate] was added to trap nuclei in mitosis, and these were detected by staining with aceto-orcein. the assumptions and controls required to relate the experimentally determined fractions to the points where a mutation blocks the nucle ...	1976	770458
initial characterization of aspergillus nidulans mutants blocked in the nuclear replication cycle.	several hundred temperature-sensitive mutants of aspergillus nidulans were screened for ability of their conidia to produce germ tubes at the nonpermissive temperature while still remaining with the original single conidial nucleus.	1976	770457
role of organic phosphates in the formation of phosphatases in aspergillus nidulans.		1975	767255
altered instability due to genetic changes in a duplication strain of aspergillus nidulans.		1975	767217
a temperature-sensitive mutant of aspergillus nidulans reversibly blocked in nuclear division.		1976	767122
hyper-repressible operator-type mutant in sulphate permease gene of aspergillus nidulans.		1976	765839
the effects of temperature on genetic instability in aspergillus nidulans.	previous work has shown that strains of aspergillus nidulans with a chromosome segment in duplicate (one in normal position, one translocated to another chromosome) are unstable. deletions occur from either duplicate segment. the present work has shown that most deletions occur from the translocated duplicate segment. furthermore, it has been found that the overall frequency of deletions from a duplication is dependent upon the temperature of growth. the overall frequency of deletions from a chr ...	1976	765807
transmission and recombination of extranuclear genes during sexual crosses in aspergillus nidulans.	three extranuclear mitochondrial mutations in aspergillus nidulans, (olia1), (cama1) and (cs67), were used as markers in sexual crosses to provide information on the frequencies of transmission and recombination of the mitochondrial genome. any individual perithecium contained ascospores of only one extranuclear genotype. using mono-, bi- and trifactorial crosses it was found that all three markers could be recovered from the progeny, although the transmission frequencies were different for each ...	1975	765748
three-marker extranuclear mitochondrial crosses in aspergillus nidulans.	two- and three-point extranuclear crosses have been carried out via heterokaryons involving the three extranuclear mitochondrial markers of aspergillus nidulans: (olia1), (cs67) and (cama112). all three markers appear to be located on a single functional mitochondrial genome. recombination between all three pairs of extranuclear markers appears to be equally frequent, suggesting a lack of genetic linkage. an important feature of these results is the variable and often marked non-equality of freq ...	1975	765725
[the effectiveness of an (aspergillus) differential medium in the course of the mycological examination of foods].	the effectiveness of aspergillus differential medium (adm) for the identification of aspergillus strains was tested. the bright yellow-orange pigment was produced by 205 (88,7%) of 231 strains and resp. 97 (61,3%) of 158 strains, which during routine mycologic diagnostic as a.flavus and a.oryzae, respectively. strains of the groups a.clavatus (76), a.glacus (100), a.fumigatus-(9), a.niger-(6), a.candidus-(3), a.wentii-(1), a.versicolor (23), a.nidulans (6), a.ustus (1) and a.terreus (1) gave neg ...	1978	706813
a new in vitro method for testing plant metabolism in mutagenicity studies.	a rapid method was proposed to detect whether a harmless agricultural chemical can be converted into a mutagenic one by plant metabolism. the method is based on the use of nicotiana alata cell cultures. results obtained with five pesticides (atrazine, dichlorvos, tetrachlorvinphos, kelevan, and maleic hydrazide) suggest that the proposed method simulates the metabolism of the whole plant. this procedure was also successfully applied to the genetic system of aspergillus nidulans. one pesticide, a ...	1979	513148
toxic aspergilli from pistachio nuts.	pistachio nut samples taken during various stages of development from orchards in iran, showed that contamination with fungi occurred mainly during the later stages of nut development. members of the genera aspergillus and penicillium occurred most frequently. of the aspergilli, the species a. niger, a. flavus and a. fischeri var. spinosus occurred most frequently, followed by a. terreus, a. tamarii and a. nidulans. twenty-two isolates comprising 13 species were tested for toxicity to ducklings. ...	1979	481560
studies on saprozoonosis. i. a survey on aspergillus species with special reference to occupational habits.	a comprehensive survey of aspergillus species has been carried out among different cattle and donkey handlers. a total of 300 pharyngeal swabs of different subjects including 100 control and 100 each from cattle and donkey handlers was investigated. all the subjects were found healthy. among the species of aspergillus, the number of a. flavus appeared higher followed by a. fumigatus, still lower number was encountered with other species like a. nidulans and a. glaucus. in order to establish the ...	1979	429763
culture and antigen variants of aspergillus.		1978	416063
adsorption of cyanophage as-1 to unicellular cyanobacteria and isolation of receptor material from anacystis nidulans.	cells of unicellular cyanobacteria of typological group ia, containing approximately 50 mol% guanine + cytosine (g+c) in their dna (r. y. stanier, r. kunisawa, m. mandel, and g. cohen-bazire, bacteriol. rev. 35:171-205, 1971), were susceptible to infection by the cyanophage as-1. cyanobacteria of the same typological group, containing approximately 65 mol% g+c in their dna, did not adsorb the cyanophage as-1 or adsorbed it at a low rate. as-1 was not propagated by any of the investigated strains ...	1978	413935
occurrence of a major protein associated with fruiting body development in neurospora and related ascomycetes.	electrophoretic and immunological analysis of fruiting body (perithecial) extracts demonstrates the occurrence of a major phase-specific perithecial protein in all neurospora species and in the closely related gelasinospora cerealis and sordariafimicola. the perithecial proteins from these different species fall into a number of groups with different electrophoretic mobilities. they appear to be immunologically closely related but not identical to one another even within the same genus, with onl ...	1977	410027
photosynthetic activity of diimidoester-modified cells, permeaplasts, and cell-free membrane fragments of the blue-green alga anacystis nidulans.	on treating the blue green alga anacystis nidulans with dimethylsuberimidate up to 70% of the free nh2 of the photosynthetic membrane is amidinated, and presumably inter- and intramolecular cross-links are established in the membrane proteins. amidination destroys the ability of a. nidulans to photoreduce hco3(-) but leaves the photochemical activities of photosystems ii and i nearly intact. with added electron acceptors, photosynthetic o2 evolution can be demonstrated both with permeable cells ...	1977	409432
interference of cellular ferric ions with dna extraction and the application to methods of dna determination.		1977	405886