Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| chronic echo type 5 virus meningoencephalitis in x-linked hypogammaglobulinemia: treatment with immune plasma. | a patient with x-linked hypogammaglobulinemia developed chronic meningoencephalitis. echo virus type 5 was repeatedly cultured from cerebrospinal fluid (csf). infusions of high-titer, specific plasma resulted in clinical improvement, but failed to eradicate the virus. after more intensive plasma infusions, the virus could not be cultured from the csf. the patient died 8 months after institution of intensive therapy. the cause of death was unknown. autopsy showed persistence of perivascular and m ... | 1979 | 572004 |
| the hemolytic uremic syndrome associated with echo 22 infection. | serologic evidence for echo virus 22 was found in 8 of 10 patients with hemolytic uremic syndrome. the virus was isolated from the stools of two patients. all these patients also had gastroenteritis prior to the development of the syndrome. the results of this study indicate that echo 22 virus is an agent with a strong association with hemolytic uremic syndrome in pediatric patients. | 1980 | 7351103 |
| fatal echovirus 11 disease in premature neonates. | four cases of fatal echovirus 11 disease occurred in premature infants during a community outbreak of enteroviral disease in massachusetts in 1979. each infant developed nonspecific symptoms and jaundice at 4 to 6 days of age, and subsequent progressive hepatic failure and generalized bleeding. only one infant survived longer than six days. virus was recovered from multiple sites premortem, and from virtually all tissue cultured at autopsy. myocarditis was not present clinically or pathologicall ... | 1980 | 7432883 |
| [effect of tannin, saponin and guanidine on the replication of echovirus 9 and its mutants]. | 1980 | 7464352 | |
| most echoviruses reach higher titers in rd than in gmk-ah 1 cells, regardless of their passage history. | stocks prepared in gmk-ah 1 cells of all 31 echovirus prototype strains were titrated simultaneously from identical dilution series in tube cultures of rd and gmk-ah 1 cells. 14 types reached titers 10 to 60 times higher in rd than in gmk-ah 1 cells. 10 other types titered 4 to 6 times higher in rd than in gmk-ah 1 cells. three prototypes only (nos. 1, 8 and 9) titered considerably lower in rd than in gmk-ah 1cells. echovirus types 22 and 23 did not replicate in rd cells. stocks of the various e ... | 1980 | 6766711 |
| [hyperbaric pressure effects ("per se" hydrostatic pressure, nitrogen and helium partial pressure) on the multiplication of a picornavirus (echo 11) in cell cultures (author's transl)]. | 1980 | 6768050 | |
| inhibitory activity of 2-aminooxazole derivatives against coxsackie b1 virus in fl cells. | the antiviral activity of three-2-aminooxazoles was studied against coxsackie b1 virus in fl cells. the virus-induced cytopathic effect was nearly completely suppressed by two of the test compounds as revealed by spectrophotometric turbidity measurements. the plaque reduction amounted to 95--100 per cent. the compounds had no effect on extracellular virus or on absorption and penetration. the inhibition of infectious virus yield in one-step growth experiments reached 94--99.9 per cent. one of th ... | 1980 | 6158853 |
| immunological studies of the group b coxsackieviruses by the sandwich enzyme-linked immunosorbent assay (elisa) and immunoprecipitation. | a microplate double antibody sandwich elisa was employed in an immunological study of the group b coxsackieviruses. the assay, described in detail, detected high dilutions of virion antigen (less than 10 ng) in purified preparations and in crude infected cell extracts. furthermore, by using a constant amount of antigen, group b virus antibodies in hamster antisera could be quantified with a sensitivity equivalent to the virus neutralization test. titrations of virus antigens and antibodies were ... | 1980 | 6161989 |
| diabetes and coxsackie virus b5 infection. | 1980 | 6101692 | |
| coxsackie-b-virus-specific igm responses in patients with cardiac and other diseases. | an enzyme-linked immunosorbent assay (elisa) test using polyvalent antigens and antisera was developed to detect coxsackie-b-virus-specific igm responses. the sera of 24 of 64 (37.5%) patients with acute pericarditis and 14 of 38 (36%) with acute myocarditis were positive for coxsackie-b-virus-specific igm. 4 of 30 (13.3%) patients with acute ischaemic heart disease and 2 of 28 (7.1%) patients with congestive cardiomyopathy were also positive. coxsackie-b-virus-specific igm was detected in the s ... | 1980 | 6107769 |
| the search for antiviral agents among corynebacteria. | extracts of strains of corynebacterium diphtheriae var. mitis avirulent, c. hofmannii, c. xerosis, c. parvum and an unidentified corynebacterium species were tested for antiviral activity against laboratory strains of echovirus type 11, adenovirus type 2 and vaccinia, and a recent isolate of herpes simplex virus. unlike a previous study, no appreciable antiviral activity was detected in the extracts tested | 1980 | 6108068 |
| coxsackie b virus infections of the heart in adults-clinical aspects and long term follow up. | 1980 | 6260732 | |
| viral content of a sewage-polluted intertidal zone. | 1980 | 6309967 | |
| influence of input multiplicity of infection on the antiviral activity of interferon. | the antiviral activity of interferon was shown to be dependent on the input m.o.i. cells could not be protected against the cytopathogenic effect of vaccinia, herpes, echo or vesicular stomatitis virus at m.o.i. greater than 1. at a m.o.i. of less than or equal to 1, cells could be protected but the amount of interferon necessary to yield protection was inversely related to the m.o.i. when protection was afforded, it was only transient. the duration of the antiviral effect of interferon was also ... | 1980 | 6243342 |
| stability of simian rotavirus in fresh and estuarine water. | the rates of inactivation of poliovirus 1, echovirus 7, coxsackievirus b3, and simian rotavirus sa11 were compared in polluted and nonpolluted fresh and estaurine water samples. the study was done in two parts, comparing virus survival in samples taken 1 year apart from the same sites. the survival studies were performed at 20 degrees c and at the natural ph of the water samples. in the first part of the study, the time required for a 3-log10 reduction in the initial virus titers was 2 to 3 days ... | 1980 | 6243899 |
| technetium-99m pyrophosphate uptake in experimental viral perimyocarditis. sequential study of myocardial uptake and pathologic correlates. | the myocardial uptake of technetium-99m pyrophosphate (99mtc-pyp) in perimyocarditis induced by coxsackievirus b3 in balb/c mice was studied. 99mtc-pyp uptake ratio, measured by the ratio of counts/min per gram for the heart to counts/min per gram for the skull, began to increase 5 days after virus inoculation when myocardial necrosis was evident. on the seventh day after the inoculation, 99mtc-pyp ratio reached a maximum. histologically, fine, dystrophic calcification appeared in the necrotic f ... | 1980 | 6244121 |
| improvement of enterovirus neutralization by treatment with sodium deoxycholate or chloroform. | enterovirus strains which could be neutralized only partially or not at all by specific antiserum were readily accessible to the antibodies after treatment with sodium deoxycholate or chloroform. the latter treatment is simple and can be performed with crude virus suspensions of low titer. the method was particularly successful for routine typing of enterovirus 71 and coxsackievirus types a7 and a16. | 1980 | 6244237 |
| clinicopathological study of coxsackie b viral myocarditis. | autopsy cases of myocarditis caused by coxsackie viruses in two infants, aged 5 years and 10 months and 12 years, and two adults, aged 24 years and 45 years, were presented. of the four cases, three revealed a rise in serum neutralization titer to cox b,4 virus and one to both cox b2 and cox b4 viruses. compared with the adult cases, the 2 infant cases showed less inflammatory response with relatively prominent hypertrophy in the heart. both of the adult cases revealed intensive inflammatory rea ... | 1980 | 6244712 |
| the role of host genetics in the pathogenesis of coxsackievirus infection in the pancreas of mice. | the susceptibility of mice to the diabetogenic effect of the m variant of encephalomyocarditis (memc) virus is probably inherited as a recissive trait. three strains of mice that were susceptible to memc virus, three strains that were not susceptible to memc virus, and three types of f1 hybrid strains were infected with the common human coxsackie virus, group b, type 4 (cb4). they were examined to determine the titer of virus and histochemistry in the pancreas, levels of blood glucose, urinalysi ... | 1980 | 6245147 |
| coxsackie b2 virus isolation from a case of postnatal meningoencephalitis. | clinical, morphopathological and virological data are presented with reference to a fatal case of postnatal meningoencephalitis from which a coxsackie b2 virus strain could be isolated. the lesions consisted mainly in a meningeal inflammatory process with fibrocytes, a few lymphocytes and rare polynuclear cells. marked stasis, diffuse and perivascular infiltrates with lymphcoytes and polynuclear cells, as well as lympho-glial nodules were observed in the brain parenchyma. | 1980 | 6246681 |
| influence of estuarine sediment on virus survival under field conditions. | the survival of poliovirus 1 (lsc) and echovirus 1 (farouk) in estuarine water and sediment was studied in galveston bay, texas. viruses were suspended in estuarine water and sediment both in dialysis tubing and in chambers constructed with polycarbonate membrane walls. virus inactivation rates in seawater were similar in both types of chambers. virus adsorption to sediment greatly increased survival time. the time required to inactivate 99% (t-99) of poliovirus increased from 1.4 days in seawat ... | 1980 | 6246838 |
| poliomyelitis-like illness associated with asthma. | a 10-year-old girl with a combination of paralytic disease, resembling poliomyelitis, and asthma is described. the girl developed neurological symptoms 5 days after a severe attack of asthma. no aetiology to the flaccid paralysis could be demonstrated although coxsackie b5 virus was isolated from a stool. a similar poliomyelitis-like illness associated with asthma has previously been reported in 13 cases from australia and the uk. | 1980 | 6246842 |
| coxsackie b virus antibody responses in juvenile-onset diabetes mellitus. | a prospective serological study of patients with recently diagnosed juvenile-onset diabetes mellitus was carried out to determine neutralizing antibody responses to coxsackie b viruses. the sera were tested with and without staphylococcal protein a absorption, to selectively ascertain whether specific igm or igg antibody predominated. of eleven patients studied, ten had reciprocal antibody titres of sixteen or greater to at least one serotype. three patients showed no reduction in titre in at le ... | 1980 | 6247107 |
| indirect enzyme-linked immunosorbent assay (elisa) for the detection of coxsackievirus group b antibodies. | an indirect, solid phase, microplate enzyme-linked immunosorbent assay (elisa) was found to be highly sensitive and reliable for detecting antibodies to the group b coxsackieviruses and other picornaviruses. conditions for obtaining maximum sensitivity and reproducibility of the indirect elisa are described. antibody titres were comparable to those obtained by the virus neutralization test and over 50 times higher than those obtained by the complement-fixation test. purified virions used in the ... | 1980 | 6247437 |
| [experimental nephritis induced by cox. b4 virus in mice (author's transl)]. | 1980 | 6247529 | |
| [myopericarditis caused by coxsackie b virus]. | 1980 | 6247662 | |
| [restoration of the sensitivity of cells resistant to coxsackie b3 virus after treatment with sensitive cell filtrate]. | the study was done with j-96 cell line sensitive to coxsackie b3 virus and the subline j-41 derived from it and resistant to this virus. in order to determine the substrates responsible for the susceptibility or resistance of these cells to coxsackie b3 virus, homogenates and filtrates of the susceptible cells were inoculated into resistant ones and vice versa. inoculation of the resistant cell homogenates into the susceptible cells at various intervals after virus inoculation did not inhibit vi ... | 1980 | 6247850 |
| evaluation of various soil water samplers for virological sampling. | two commercially available soil water samplers and a ceramic sampler constructed in our laboratories were evaluated for their ability to recover viruses from both tap water and secondary sewage effluent. the ceramic sampler consistently gave the best recoveries of viruses from water samples. soil columns containing ceramic samplers at various depths provide a simple method for studying virus transport through sewage-contaminated soils. | 1980 | 6247976 |
| [case of coxsackie virus infection with multiple organ involvement]. | 1980 | 6249044 | |
| detection of enterovirus specific igg and igm antibodies in humans by an indirect solid phase radioimmunoassay. | the development of a solid phase radioimmunoassay which is able to detect virus-specific igg and igm antibodies in serum specimens from patients with enterovirus infections is described. viral antigen partially purified from infected tissue culture fluid was absorbed passively to individual polystyrene microtiter wells. dilutions of sera were incubated on these antigens and bound anti-viral antibodies were monitored by the addition of 125-iodine labeled anti-human-igg or anti-human-igm antibody. ... | 1980 | 6250017 |
| virus infections of the myocardium. | 1980 | 6250138 | |
| [viruses and the kidneys]. | 1980 | 6250241 | |
| [diagnostic value of detecting neutralizing antibodies to coxsackie b enteroviruses in patients with infectious-allergic myocarditis]. | the clinical virological survey of 180 cardiological patients aged 16-60 years with clinically diagnosed infectious allergic myocarditis (100), rheumatism (38) and other cardiac diseases (42) was made. a group of 97 practically healthy adults aged 21-60 years was used for control. the survey revealed statistically significant differences in the frequency of occurrence of coxsackie b virus in healthy persons and in cardiac patients. thus the criteria of the diagnostic significance of the results ... | 1980 | 6250306 |
| survival of human enteroviruses in the hawaiian ocean environment: evidence for virus-inactivating microorganisms. | the stability of certain human enteroviruses in the hawaiian ocean environment was examined. the present data indicated that the time for 90% reduction of poliovirus type 1 at 24 +/- 1 degree c in seawater samples obtained from different sites in hawaii ranged from 24 to 48 h, and complete inactivation occurred within 72 to 96 h. the accumulated evidence also strongly indicated that a virus-inactivating agent(s) of a microbiological nature was present in both clean and sewage-polluted seawaters, ... | 1980 | 6250472 |
| [effect of different doses of diphtheria exotoxin on the properties of l929 and hela cells]. | various forms of interaction between diphtheria exotoxin and the continuous l and hela cell lines were revealed, depending on its doses: toxic, subtoxic and small (following the subtoxic dose). cells of the same origin, treated with these doses, develop similar changes in some of their properties, differing only in their "survival" time, the period of adaptation and the time of entering the phase of active proliferation. the systems of cells, having simultaneously low susceptibility to infection ... | 1980 | 6251678 |
| coxsackie virus b3 perimyocarditis in balb/c mice: experimental model of chronic perimyocarditis in the right ventricle. | severe perimyocarditis was induced in weanling balb/c mice inoculated with coxsackie virus b3 (nancy strain). yellowish-white patches were seen only on the surface of the right ventricle of the heart on the 7th to the 180th day after the inoculation. more than half the animals were affected. following myocardial degeneration and necrosis, mononuclear cell infiltration was evident on the 7th day. after the 28th day, perimyocardial fibrosis increased and cellular infiltration gradually decreased. ... | 1980 | 6253611 |
| residual pathologic changes and 99mtechnetium pyrophosphate uptake following coxsackievirus b3 perimyocarditis in mice. | the myocardial uptake of technetium-99m pyrophosphate (99mtc-pyp) in perimyocarditis induced by coxsackievirus b3 in balb/c mice was studied on 3rd--90th day after the inoculation. 99mtc-pyp uptake ratio, measured by the ratio of cpm/gm for the heart to cpm/gm for the skull, began to increase five days after virus inoculation and reached a maximum on the seventh day. after the 14th day, 99mtc-pyp ratio began to decrease, however, on the 90th day, a high 99mtc-pyp uptake was shown in mice with se ... | 1980 | 6253697 |
| experimental coxsackievirus b3 perimyocarditis in the right ventricle in balb/c mice: a one-year follow-up study. | we described severe perimyocarditis in weanling balb/c mice inoculated with coxsackievirus b3 (nancy strain) which was exclusively limited to the right ventricle. yellowish-white patches were seen on the surface of the right ventricle of the heart on the seventh day through 360th day after inoculation with virus. following myocardial degeneration and necrosis, marked perimyocardial fibrosis with calcification was observed 90 days after inoculation with virus and persisted through 360th day. spon ... | 1980 | 6253698 |
| induction of diabetes by cumulative environmental insults from viruses and chemicals. | encephalomyocarditis virus (emc) induces diabetes in certain inbred strains of mice by infecting and destroying pancreatic beta cells, the severity of the diabetes depending on the number of beta cells destroyed. in strains of mice resistant to emc-induced diabetes, insufficient beta cells are damaged to alter glucose homeostasis. however, diabetes can be produced in many species by streptozotocin, a highly specific beta-cell toxin. here, we used concentrations of streptozotocin that did not pro ... | 1980 | 6253833 |
| [viral neuraxitis. further studies of the current epidemiological and clinical aspects]. | an epidemiological and clinical investigation upon ten cases of acute viral neuraxitis observed in the country of alessandria between january 1978 - january 1979, is reported. four cases of neuraxitis were due to coxsackie b4 virus, two to coxsackie b3, two to influenza type a and one to influenza type b virus, one to rubella and one to varicella-zooster virus. in all the cases blood chemistry, clinical and instrumental examinations (eegraphy, cerebral scintigraphy and angiography) were coupled ... | 1980 | 6253851 |
| [karyotype change in human cell cultures in the process of the reversion of coxsackie b virus sensitivity]. | the study was done on a subline of cells reverting to sensitivity to coxsackie b3 virus after treatment of j-41 cells resistant to this virus with a homogenate prepared from the sensitive j-96 cell culture. cytogenetic examinations of this cell subline showed its karyological characteristics to approach those of the sensitive j-96 culture. the modal number of chromosomes and the number of chromosomes 2, 9, 11, 12, and 21 were completely restored and marker chromosomes typical of the sensitive cu ... | 1980 | 6254264 |
| [virological analyses of irradiated sewer sludge (author's transl)]. | the virus-inactivating effect of co60 irradiation was verified by a field test in the sewer sludge irradiation plant at geiselbullach near munich. the following samples were tested: 16 waste water inlets 15 waste water outlets 32 fresh sludge samples 62 sewer sludge samples prior to irradiation 52 sewer sludge samples and 9 fresh sludge samples after irradiation. we supplemented these analyses by inoculating sewer sludge samples with polio inoculation virus type 1 before irradiation and by the a ... | 1980 | 6254288 |
| "coxsackie virus in diabetes mellitus". | 1980 | 6256289 | |
| [studies on the interference system between "cold" and "hot" mutants of coxsackie b 6 virus]. | 1980 | 6257991 | |
| survival of enteroviruses in rapid-infiltration basins during the land application of wastewater. | the downward migration through soil of seeded poliovirus type 1 and echovirus type 1 and of naturally occurring enteroviruses during infiltration of sewage effluent through rapid-infiltration basins was investigated. after 5 days of flooding, the amount of seeded poliovirus type 1 that had migrated 5 to 10 cm downward through the soil profile was found to be 11% of that remaining at the initial burial depth. the amount of echovirus type 1 determined to have moved an equal distance was at least 1 ... | 1980 | 6258471 |
| comparative inactivation of viruses by chlorine. | the kinetics of inactivation of six enteric viruses plus simian virus 40 and kilham rat virus by free available chlorine was studied under carefully controlled laboratory conditions. it was found that the different virus types demonstrated a wide range of susceptibility to chlorine disinfection. the rate of inactivation was greater at ph 6 than at ph 10; however, the relative susceptibilities of the different viruses were affected differently by a change in ph, suggesting that the ph influenced ... | 1980 | 6258473 |
| [recovery of the sensitivity of j-41 cells to coxsackie b3 virus by treatment with exogenous alkaline phosphatase]. | it has been shown that injection of g-41 cell cultures, deficient as regards alkaline phosphatase and resistant to coxsackie b3 virus, in conjunction with exposure to an alkaline phosphatase preparation from the calf intestine results in virus reproduction. depending on the dose administered and multiplicity of infection there occur either complete destruction of the monolayer or death of some cells with the development of cytopathic changes specific for coxackie virus. | 1980 | 6258669 |
| infectivity titers of enterovirus as found in human stools. | data have been gathered and collated from a variety of sources both published and unpublished, dealing with the concentration of enteroviruses in human stools. for polioviruses, a general range of 3.0-6.5 log10 tcd50 per gram of stool was reported, whereas for coxsackieviruses and echoviruses the range has been from 2.0-5.5 log10 tcd50. as human stools average about 100 gm, it is not unusual for an infected person to excrete as much as 10-300 million tcd50 of virus daily. the results of enterovi ... | 1980 | 6262449 |
| enzyme-linked immunosorbent assay for the detection and identification of coxsackie b antigen in tissue cultures and clinical specimens. | an enzyme-linked immunosorbent assay (elisa) has been developed for the identification of coxsackie b antigens. this assay was capable of identifying and distinguishing all six coxsackie b serotypes at concentrations one hundredfold to ten thousandfold less than could be detected by complement fixation (cf) systems. in addition, the coxsackie b elisa correctly identified the presence of coxsackie b antigen in 19 of 21 tissue culture fluids and five of nine rectal swab specimens. two additional r ... | 1980 | 6262456 |
| survival of enteroviruses and coliform bacteria in a sludge lagoon. | enteroviruses associate with aerobically and anaerobically digested sludge were determined before the addition of the sludge to a sludge lagoon. the fate of sludge-associated viruses was followed during detention of sludge in the lagoon and after application of sludge to land for disposal. while digested sludge was being added to the lagoon, enteroviruses were readily detected in grab samples of sludge from the lagoon. sludge-associated viruses dropped to low or undetectable levels after disposa ... | 1981 | 6263184 |
| procedure for recovery of enteroviruses from the japanese cockle tapes japonica. | the most likely shellfish to be harvested if sportfishing is reinstated in san francisco bay is the japanese cockle tapes japonica. the virus levels present in these shellfish are unknown and need to be evaluated before the shellfish beds are open. towards this end, a procedure for recovering and concentrating enteric viruses from these clams has been evaluated. effective elution of poliovirus from clam tissues was found to occur with ph 9.5 glycine-buffered saline rather than with the ph 7.5 fl ... | 1981 | 6263186 |
| ultrastructural alterations of the myocardium in coxsackie b-3 virus myocarditis in mice. 18 months follow-up study by transmission and analytical electron microscopy. | 1981 | 6264176 | |
| experimental coxsackie b-3 virus myocarditis in golden hamsters. light and electron microscopy findings in a long-term follow-up study. | following intraperitoneal inoculation with coxsackie b3 virus all weaning syrian golden hamsters (60 animals) developed severe myocarditis. in the acute phase, light and electron microscopy revealed massive cellular infiltration and myocytolysis in the myocardium which were most prominent on the 5th day and least obvious in 3 weeks. in the necrotic myocytes, mitochondria contained moderately electron dense inclusions different from the calcified granules seen in the myocardium of mice with coxsa ... | 1981 | 6264177 |
| survival following myocarditis and myocardial calcification associated with infection by coxsackie virus b-4. | a coxsackie virus b-4 was isolated from a neonate with clinical sepsis and clinical evidence of myocardial dysfunction. radiographs demonstrated the presence and subsequent resolution of myocardial calcification. electrocardiograms showed a left bundle branch block, presumably caused by calcification in the corresponding segment of the bundle of his. this case demonstrates an unusual complication of neonatal coxsackie virus b infection. | 1981 | 6264379 |
| survival of polioviruses and echoviruses in acanthamoeba castellanii cultivated in vitro. | cultures of acanthamoeba castellanii, kept at room temperature in sterile bacto-casitone (difco) medium, were artificially infected with vaccination poliovirus strains type 1 and type 3 and with echovirus type 4 and echovirus type 30. no remarkable virus cumulation was observed on the surface or inside amoeba cells during the observation period of 21 days. amoeba-adsorbed viruses were impossible to remove by repeated washings. virus neutralization with specific antisera showed that enteroviruses ... | 1981 | 6265550 |
| the viral factor in the etiology of acute asthma attacks in children. | over the last decade firm proponents of a viral etiology have risen, alongside those considering mycoplasma as prime agent in the induction of bronchospasm. since we are not convinced as to the validity of the viral hypothesis, we decided to study a group of asthmatics to detect the different viral antigens serologically, in order to determine which can play a decisive role in the pathogenesis of the asthmatic crisis. without previous etiologic selection, 37 children admitted as emergency cases ... | 1981 | 6266242 |
| effect of soil permeability on virus removal through soil columns. | laboratory experiments were performed on four different soils, using 100 cm long columns, to determine the extent of virus movement when wastewater percolated through the soils at various hydraulic flow rates. unchlorinated secondary sewage effluent seeded with either poliovirus type 1 (strain lsc) or echovirus type 1 (isolate v239) was continuously applied to soil columns for 3 to 4 days at constant flow rates. water samples were extracted daily from ceramic samplers at various depths of the co ... | 1981 | 6266338 |
| experimental coxsackie b virus myocarditis in mice: 18 month histopathological and virological study. | in a series of experimental studies to test the hypothesis that idiopathic cardiomyopathy in man represents a sequela of virus myocarditis, coxsackie b 1, 3 or 5 virus was inoculated into icr mice with two different amounts, that is, a small amount (0.1 ml of 10(5.5) tcid50/ml) and a large amount (0.1 ml of 10(7.5) tcid50/ml). histopathological and immunofluorescent studies of the heart, analysis of the antibody titers in sera and evaluation of the virus concentration in various organs including ... | 1981 | 6267334 |
| [case of recurrent encephalomyeloradiculomeningitis after coxsackievirus infection]. | the authors report a case of recurring encephalomyeloradiculomeningitis after coxsackie b4 virus infection in a boy aged 14 years. the peculiar course of the disease is interpreted as an expression of the neuroallergic process caused by preceding viral infection. | 1981 | 6267497 |
| paralytic poliomyelitis: old dogmas and new perspectives. | no poliovirus vaccines can be expected to eliminate the paralytic poliomyelitis that is caused by nonpolio enteroviruses or the cases that have been and continue to be diagnosed erroneously as paralytic poliomyelitis. polioviruses have been recovered from the feces of patients with paralytic disease that is definitely not poliomyelitis, and very rare cases of so-called "vaccine-associated" paralytic disease cannot be regarded as having been caused by the vaccine virus when it is present in the f ... | 1981 | 6269169 |
| serum substitute in epithelial cell culture media: nonfat dry milk filtrate. | a number of milk types and milk fractions were investigated as possible substitutes for serum in cell culture media. a filtrate of reconstituted nonfat dry milk showed promise. culture fluids containing 5% of the nonfat dry milk filtrate were used to propagate primary and continuous cell cultures, and the cell growth from these cultures was compared with that of cells grown in a serum-containing medium. the nonfat dry milk filtrate-supplemented medium supported the growth of all epithelial cells ... | 1981 | 6269491 |
| comparison of proliferation and cytopathogenicity of swine vesicular virus and coxsackievirus b5. | sequential appearance of both swine vesicular disease virus and coxsackievirus b5 antigens in a pig kidney cell line was studied by immunofluorescence and electron microscopy. the replication cycle of each virus was approximately 3-4 h. viral antigens were demonstrable in the cytoplasm 2 h after inoculation. a compact mass of fluorescence was seen when cells showed cytopathogenic effect at 5.5 h. after 3 h, a few viral particles, seen by electron microscopy, were in the cytoplasm. morphological ... | 1981 | 6269809 |
| proteolytic cleavage of vp1 in 'a' particles of coxsackievirus b3 does not appear to mediate virus uncoating by hela cells. | 'a' particle of coxsackievirus b3 were generated from native virus by heating and purified by sucrose gradient centrifugation. these particles were found to be similar to 'a' particles formed by elution from cellular receptors of hela cells. electrophoretic analysis of [35s]methionine-labelled 'a' particles revealed that treatment of the particles with chymotrypsin resulted in the cleavage of vp1 and the formation of a cleavage product which migrated between vp2 and vp3. analysis of the protease ... | 1981 | 6270273 |
| [role of viruses in the etiology of endocrine diseases]. | 1981 | 6270646 | |
| investigations on the circulation of viruses occurring in the respiratory tract of apparently healthy schoolchildren aged 7 to 14 years. | a number of 92 viral agents could be isolated from 1,000 nasopharyngeal secretion samples collected from apparently healthy schoolchildren aged 7-14 years. the following viruses were identified, in decreasing order of frequency: 42 influenza a/ussr 90/77 (h1n1), 20 adeno-, 20 parainfluenza, 8 coxsackie b1 and 2 herpes virus strains. | 1981 | 6272482 |
| comparison of capsid polypeptides of group b coxsackie-viruses and polypeptide synthesis in infected cells. | capsid polypeptides of all six types (b1-6) of group b coxsackieviruses were compared by high-resolution gel electrophoresis, and synthesis of protein and rna in b4- or b5-infected hela cells was analyzed. four polypeptides, vp1-4, were detected in each type. another polypeptide, vp0, slightly larger than vp1, was also detected in trace amounts in some types. vp1-3 showed different but characteristic molecular weights (vp1, 34,500 to 37,000; vp2, 31,000 to 36,000; vp3, 26,000 to 32,500), and pre ... | 1981 | 6275818 |
| [case of viral myocarditis with exudative pericarditis caused by coxsackie b3 virus]. | 1981 | 6278395 | |
| [coxsackie b virus neuropapillitis (author's transl)]. | 1981 | 6278558 | |
| virological study of idiopathic cardiomyopathy: serological study of virus antibodies and immunofluorescent study of myocardial biopsies. | in 113 patients with idiopathic cardiomyopathy paired sera obtained 2--4 weeks apart were examined for neutralizing antibody to coxsackie b 1--6, and echo 4, 6, 7, 9 and 11 viruses. only eight cases (6.9 per cent) showed a significant change in titer, indicating a virus infection during or shortly before the study. complement-fixing antibody titers were measured in 126 patients and neutralizing antibodies in 116 patients with idiopathic cardiomyopathy. more patients had complement-fixing antibod ... | 1981 | 6259384 |
| [karyological characteristics of the transplantable human cell line j-96, susceptible to coxsackie b3 virus, and of its derived subline j-41, specifically resistant to this virus]. | the paper is concerned with comparative cytogenetic studies of human cell line j-96 and subline j-41 derived from it. application of g-, r- and c-techniques for differential staining of chromosomes made it possible to determine both numeric and structural changes in chromosomes of the resistant subline as compared to the initial one. the mechanisms contributing to a decrease in the normal chromosome number and to appearance of new marker chromosomes in the resistant subline cells are discussed a ... | 1981 | 6259787 |
| pancreatic uptake of 99tc stannous pyrophosphate in experimental viral pancreatitis in mice. | the pancreatic uptake of 99mtc stannous pyrophosphate (99mtc-pyp) in acute pancreatitis in mice induced by coxsackievirus b3 was studied. 99mtc-pyp uptake ratio, measured by the ratio of counts/min/g for the pancreas to counts/min/g for the skull, began to increase 2 days after virus inoculation and markedly increased on day 3 when necrosis of pancreatic acinar cells was evident. on day 5, 99mtc-pyp ratio reached a maximum (2.95 +/- 1.85, mean +/- sd) and histologically fine granules of calcific ... | 1981 | 6260500 |
| sex-related differences in the pattern of coxsackievirus b-3-induced immune spleen cell cytotoxicity against virus-infected myofibers. | spleen cells from adult balb/c mice injected intraperitoneally with purified coxsackievirus b-3 were tested for cytotoxicity against 51cr-labeled syngeneic infected and uninfected myofibers. both male and female immune cells were active against uninfected targets; this reactivity was evident by day 3 of infection and persisted throughout the first week. however, we observed marked sex-related differences in immune cell cytotoxicities against infected myofibers. males exhibited a strong t-lymphoc ... | 1981 | 6260687 |
| virus infection of endothelial cells. | endothelial injury is important in the pathogenesis of thrombosis, atherosclerosis, disseminated intravascular coagulation, and vasculitis. the ability of several common human viruses to infect cultures of endothelial cells obtained from human umbilical veins or bovine thoracic aorta was demonstrated. indicators of infection included cytopathology, viral growth curves, and antigen detection by immunofluorescence. herpes simplex virus type 1, adenovirus type 7, measles virus, and parainfluenza vi ... | 1981 | 6260874 |
| uptake and survival of enteric viruses in the blue crab, callinectes sapidus. | uptake of poliovirus 1 by the blue crab, callinectes sapidus, was measured to assess the likelihood of contamination by human enteric viruses. virus was found in all parts of the crab within 2 h after the crab was placed in contaminated artificial seawater. the highest concentrations of virus were found in the hemolymph and digestive tract, but the meat also contained virus. the concentration of virus in the crabs was generally less than in the surrounding water. changes in salinity did not subs ... | 1981 | 6261683 |
| inactivation of poliovirus and other enteroviruses by solutions of sodium fluoride at low ph. | solutions of sodium fluoride at ph 3 to 4 inactivated enteroviruses, whereas other sodium salts had little or no effect on virus infectivity. solutions of potassium fluoride also inactivated viruses under similar conditions. light, temperature, and the presence of organic compounds such as detergents and fecal matter did not affect inactivation of virus by 0.4 m solutions of sodium fluoride at ph 3. to 4. decreasing the sodium fluoride concentration below 0.04 m or raising the ph above 4 reduced ... | 1981 | 6261691 |
| [seroepidemiology of infections by coxsackie group b virus, types 1-6, herpes simplex virus, and lymphocytic choriomeningitis virus in a population of healthy adults and children. cf reaction using dextran t 70 as an adjuvant]. | 1981 | 6182843 | |
| [virus-induced changes in heart and skeletal muscle]. | 1981 | 6289544 | |
| ultrastructural degenerative changes of age-dependent echo 9 virus-induced polymyositis in infant mice. | experimental inoculation of newborn nmri mice with echo virus, type 9, strain a. barty *echo 9 virus ab) resulted in diffuse polymyositis 4 days later. the disease, after a delay of 1 day, increased in intensity and was accompanied by a rapid, progressive paresis leading to death 7-11 days following infection. as early as 24-48 h after inoculation, we detected initial ultrastructural degenerative changes, characterized by segmental dilation fo the sarcoplasmic reticulum. disruption and breakage ... | 1981 | 6112816 |
| comparative cytogenetic study of a continuous human cell line and its subline susceptible and resistant, respectively, to coxsackie b3 virus. | cytogenetic characteristics of the j-96 human cell line and its j-41 subline, highly susceptible and resistant, respectively, to coxsackie b3 virus, were compared. the j-41 subline, as compared to the original j-96 line, had fewer chromosomes in the modal class cells (54-57 and 58-62, respectively) mostly at the expense of normal chromosomes. in most j-41 cells chromosome 21 was eliminated and the number of homologues of chromosomes 2, 9, 11, and 12 was reduced. the percentage of marker chromoso ... | 1981 | 6112861 |
| [stability of c-band heterochromatin polymorphism in 2 transplantable human cell lines differing in sensitivity to coxsackie virus b3]. | heterochromatin of chromosomes is studied by means of a c-banding technique for the j-96 line of human cells, which is susceptible to enteroviruses and for the j-41 cell line derived from this culture and possessing high specific resistance to coxsackie b viruses. the data obtained demonstrate stability of variform c-heterochromatin of chromosome pairs 1, 9 16 and certain marker chromosomes in the course of long-term cultivation. | 1981 | 6165117 |
| perinatal echovirus infection: risk of transmission during a community outbreak. | during a community outbreak of enterovirus infection, seven of 194 pregnant women (3.6 per cent) were found to be excreting a prime strain of echovirus 11 at term. each of the seven women possessed serum neutralizing echovirus 11 antibody in titers ranging from 1:20 to 1:320, and the cord serum of their seven infants had antibody in titers of 1:10 to 1:640. none of these seven infants became ill, but four were shedding virus from the respiratory or gastrointestinal tract by three days of age. in ... | 1981 | 7254269 |
| selective inhibition of human neutrophil chemotaxis by echo-virus, type 9. | preincubation (37 degrees c, 60 min) of human neutrophilic granulocytes with various concentrations of infectious echo virus, type 9, strain a. barty resulted in virus-dose dependent inhibition of neutrophil chemotactic reactivity (boyden-chamber assay) to chemoattractants (f-met-leu-phen: zymosan-activated human serum). other cellular functions-phagocytosis, increase of oxidative cell metabolism, intracellular killing of live staphylococci--remained intact. this selective inhibition of human ne ... | 1981 | 7265813 |
| echovirus type 11 infection in melbourne--1953 to 1980. | echovirus type 11 (echo 11) has been isolated at the virus laboratory of fairfield hospital, melbourne, australia, in 20 of the 28 years since the laboratory was established. during this time two major epidemics have occurred; the first, in 1971-2 involved 90 patients with aseptic meningitis or respiratory illness. the second began in june 1979 and lasted for 11 months, during which echo 11 was isolated from 174 patients admitted to fairfield hospital, other victorian and tasmanian hospitals and ... | 1981 | 7288182 |
| [characteristics of echo-19 virus strain rad/40 causing an experimental lesion of the vascular coat of the eye (uveitis) in cynomolgus monkeys]. | four strains of echo-19 virus were isolated from a child with respiratory disease complicated with uveitis. a freshly isolated rad/40 strain of echo-19 virus was found to produce a severe disease of the vascular coat of the eye (uveitis) in javan cercopithecus monkeys inoculated directly into the anterior chamber of the eye. experimental uveitis is characterized by marked changes in the shape of the pupil, the lack of the pupil reaction to light, development of synechias, changes in the color of ... | 1982 | 6760552 |
| epidemiology of an outbreak in a maternity unit of infections with an antigenic variant of echovirus 11. | after an 8-day-old child had died with clinical signs of septicemia, 6 other newborns fell ill. virus was isolated from various sites from all the 6 children (28 isolations). the agent was identified by cross neutralization tests as an antigenic variant of echovirus 11. the agent could not be isolated from mothers or nursery staff (49 people). we therefore tried to trace the path of infection by isolating specific igm and igg antibodies. a laboratory infection by the agent isolated enabled the t ... | 1982 | 7069410 |
| echovirus 11 dense particles: isolation and preliminary characterization. | dense particles (density 1.44 g/ml) were isolated during purification in cscl of echovirus 11 produced in hela cells. the dense particles had similar antigenic properties and similar rna and protein composition to standard (density 1.33 g/ml) echovirus 11 particles. they differed from standard particles in their higher buoyant density, lower infectivity and slightly smaller diameter. in contrast to other picornavirus dense particles, echovirus 11 dense particles were present as a major component ... | 1982 | 7097249 |
| biochemistry and pathogenicity of echovirus 9. i. characterization of the virus particles of strains barty and hill. | 1982 | 7147713 | |
| selective inhibition of human neutrophilic chemotaxis by echo virus, type 9. virus-induced changes in membrane fluidity. | by means of the excimer-forming lipid technique changes of membrane fluidity of human pmns exposed to a chemoattractant (fmlp) and/or echo virus, type 9, strain a. barty has been investigated. it was shown that preincubation of pmns with echo 9 virus results in a viral dose-dependent decrease of membrane fluidity of granulocytes exposed to fmlp. the virus-induced rigidity of cell membrane causes obviously a disturbance in the aggregation of membrane particles to form receptors, and thus can lead ... | 1982 | 7182838 |
| patterns of interaction of effects of light metabolically inert gases with those of hydrostatic pressure as such--a review. | this review of available literature attempts to interpret net effects of metabolically inert light gases (he, h2, and ne) as the resultant of hydrostatic pressure and intrinsic pharmacological effects associated with exposure to these gases, and to assess the relative importance of each component with respect to a number of biological responses. a common pattern is recognizable for pressure reversal of anesthesia, high pressure convulsions, high pressure bradycardia, and certain characteristics ... | 1982 | 6301124 |
| [epidemic chest pain caused by coxsackie virus b3]. | 1982 | 6309400 | |
| two cases of viral myocarditis and one case of viral pericarditis. | two cases of myocarditis, who had suffered from ventricular extrasystole, leucocytosis and elevated serum enzyme for a long period died from congestive heart failure and/or arrhythmias. the biopsy specimens from the right ventricle in one of them showed a positive reaction against coxsackie b virus (1, 3, 4 and 5) in the fluorescent antibody method. one case of virus pericarditis had 5 recurrences over a five-year period. he suffered from dyspnea, chest oppression and general fatigue at each rec ... | 1982 | 6182311 |
| coxsackie b virus infection associated with hypoparathyroidism in a neonate. | 1982 | 6129479 | |
| development of a shaker culture of buffalo green monkey kidney cells: potential use for detection of enteroviruses. | buffalo green monkey kidney cells were adapted to grow as shaker cultures. replication of environmental and clinical isolates of poliovirus, coxsackievirus, and echovirus in these cultures was analyzed by plaque assay and compared with replication in buffalo green monkey kidney cell monolayers and hep-2 cell shaker cultures. dose-response tests with various concentrations of mahoney type 1 poliovirus indicated that buffalo green monkey kidney cell shaker cultures could detect as little as 1 pfu ... | 1982 | 6289745 |
| [laboratory contribution in the etiologic definition of viral pericarditis]. | 1982 | 6290946 | |
| impairment of immunocompetent mouse spleen cell functions by infection with coxsackievirus b3. | early after infection, mice inoculated with coxsackievirus b3 showed consistent reduction of antibody responsiveness. beginning one week after infection they also evidenced progressive spleen atrophy. the cellular basis of the reduced antibody response exhibited in vitro by spleen cells of infected mice at the onset of atrophy was investigated by the use of different antigens, by supplementation with different subpopulations of immunocompetent cells from normal donors, and by cross-recombination ... | 1982 | 6292311 |
| acute polyarthritis associated with active epstein-barr virus infection. | nine patients with an initial onset of symptoms of acute arthritis within the preceding four weeks were enrolled in a prospective serological study with clinical follow-up for six months to two years. four adults with chronic rheumatoid arthritis and ten healthy adults were similarly studied. serial titers measured included antibodies to epstein-barr virus (ebv) antigens, group b coxsackieviruses, rubella virus, cytomegalovirus, and herpes simplex virus. serological evidence of active ebv infect ... | 1982 | 6292536 |
| peripheral facial palsy and infections- findings and problems. | eighty-four patients of the cologne university ent clinic with a diagnosis of idiopathic peripheral facial palsy (pep) were examined - both clinically and virologically. in addition, examinations were carried out on 33 further pfp-patients from different practising physicians (group b) where the clinical information, however, was much less detailed. in the ent clinical group (84 patients), there was a total of 12 recent virus infections (9 varicella zoster virus, 2 herpes simplex virus, 1 coxsac ... | 1982 | 6292678 |
| preliminary data on the survival length of enteroviruses in nonalcoholic beverages. inactivating action of some medicinal herb infusions. | vaccinal poliovirus type 1, coxsackie b3 virus and echovirus type 1 survived in mineral water, camomile infusion and coffee for over 20 days. in contrast, chinese tea, lime and mint infusions had a possibly transient inactivating effect on the same enterovirus strains. there was a direct relationship between the concentration of the infusions and their inactivating action. the vaccinal poliovirus was more sensitive than coxsackie and echoviruses to the inactivating action of the infusions. | 1982 | 6293171 |
| [possible localization of the gene of sensitivity of human cells to coxsackie b virus in the short arm of chromosome 21]. | 1982 | 6293606 | |
| neuraminidase-sensitive erythrocyte receptor for enterovirus type 70. | enterovirus type 70 (ev70) agglutinated human 'o' erythrocytes at 4 degrees c as well as 22 degrees c, but visible agglutination was lost when warmed at 37 degrees c although the virus remained attached to the surface of the erythrocyte. the receptor sites for the virus were neuraminidase-sensitive. a direct involvement of sialic acid on the cell surface in virus-cell interaction was confirmed by the fact that the presence of fetuin or free n-acetylneuraminic acid inhibited the haemagglutinating ... | 1982 | 6294226 |