Publications

[detection of complement fixing antibodies against herpes simplex virus (and other neurotropic viruses) in patients with multiple sclerosis].		1973	4350584
antiviral activity of isoprinosine in vitro and in vivo.		1973	4350802
polioviruses, coxsackieviruses, and echoviruses comparison of the genomes by rna hybridization.	hybridization of single-stranded rna from virions of human enteroviruses with denatured double-stranded rna from infected cells indicates that a minimum of about 5% of the genome is shared by these viruses. polynucleotide sequence relationships, furthermore, are consistent with the biologic classification into polioviruses, coxsackieviruses groups a and b, and echoviruses. in general, about 30 to 50% of the nucleotide sequences are shared by different serotypes of virus within each of these majo ...	1973	4351457
experiences from investigations of virus isolations from sewage over a two year period with special regard to polioviruses.		1973	4352066
viruses causing common respiratory infections in man. ii. enteroviruses and paramyxoviruses.		1973	4353933
interferon responsiveness of rabbit synovial cells and chondrocytes.	rabbit synovial cells (sc), articular chondrocytes (ac), and epiphyseal (ec) chondrocytes were grown in vitro. a portion of the spectrum of human pathogenic viruses infective for the cells was determined. responses of the cells to different viruses or a chemical inducer of interferon varied, with ec responding vigorously and with high titers, ac responding only to chemical inducer and influenza virus, and sc producing no detectable interferon. all cells supported prolonged growth of influenza vi ...	1973	4354150
filtration methods for recovering enteroviruses from foods.	a set of simple, rapid filtration methods has been developed for recovering enteroviruses from foods. the methods employ quite inexpensive equipment, and the resulting extract might be concentrated in any of several ways. three model enteroviruses were apparently recovered with at least 80% efficiency when inoculated, at levels ranging from thousands to one plaque-forming unit per 20-g sample, into eleven foods representing six major food groups.	1973	4355260
[properties of the rh cell line].		1973	4357539
who collaborative studies on enterovirus reference antisera; fourth report.	this paper summarizes the results of the fourth part of a comprehensive programme undertaken by the who international reference centre for enteroviruses and other laboratories for the testing of enterovirus equine antisera prepared for long-term use as reference antisera. the studies were designed to appraise the specificity of the immune serum of horses inoculated with prototype enteroviruses (coxsackievirus types a2, 4, 8, 10, 11, 14-16, 18-21, and 24, and echoviruses e21, 27, 30, 31, and 33). ...	1973	4357975
perinatal infections and epidemiology of anencephaly and spina bifida.		1973	4358489
the influence of polymyxin b on virus-induced cytopathogenic effect.		1973	4358742
enterovirus recovery with vegetable floc.	a lettuce floc was prepared and used for recovering enterovirus from an aqueous suspension. the method is simple, and the adsorption of coxsackievirus b5, echovirus 7, and poliovirus 1 is quantitative. the virus-floc complex may be removed from aqueous suspension by low-speed centrifugation and dissolved at an alkaline ph in a small volume of water; virus is then available for assay on cultured cells. flocs from some other green vegetables also possess the property of virus adsorption	1973	4356468
picornavirus receptors and picornavirus multiplication in human-mouse hybrid cell lines.		1973	4353524
relation between the time at which cytopathic endpoint occurs in infected cultures and the initial infective virus dose, with application to the study of inhibitors of cytopathic effect.		1973	4354236
a physico-chemical sub-grouping of the mammalian picornaviruses.		1973	4351695
an outbreak of aseptic meningitis due to echo virus type 4: clinical and laboratory observations.		1973	4691962
[effect of migillin on the formation of virus-neutralizing antibodies].		1973	4685112
heterogeneity of echovirus type 17: comparison of the two lines of the prototype strain.		1973	4204550
isolation of glucosamine from the capsids of a picornavirus.		1973	4200694
echovirus type 17 in the neonate.	an outbreak of echovirus type 17 in a neonatal nursery with recovery of virus from the stools of the seven affected infants and the cerebrospinal fluid of one is described. intensive nursing care and supportive therapy prevented a possible fatal outcome in all instances. a further case in another community is described in which a 5-week-old child succumbed to his illness and echovirus type 17 was isolated from autopsy tissues - lung, liver, kidney and spleen. this child had presumably received p ...	1973	4196425
[microneutralization test for the determination of some echo virus antibodies using gmk cell line (author's transl)].		1973	4271760
ultrastructural study of viral replication in human fetal intestinal organ culture.		1973	4121665
coupling of peroxidase to poliovirus antibody: characteristics of the conjugates and their use in virus detection.	antibody to poliovirus type 1 (po-1) was coupled to peroxidase by use of glutaraldehyde or 4, 4' -difluoro,3, 3' -dinitro diphenyl sulfone. glutaraldehyde was found to be the superior coupling agent, yielding conjugates that had up to 2.8 x 10(4) enzyme units/ml (75% of total enzyme input). conjugates migrated as a single band when centrifuged in sucrose density gradients, demonstrating that the purification procedure used was effective in removing both noncoupled enzyme and heterogeneous antibo ...	1973	4126429
letter: virus particles in gastroenteritis.		1973	4129337
[plaque production in vero cells by echo virus].		1973	4207165
characterization of echovirus types 7, 12, and 29 hemagglutinins for human and monkey erythrocytes.		1974	4206511
progress with antiviral agents.		1974	4137135
[virus-inactivating effectiveness of different methods of effluent treatment].		1974	4154617
an electron microscopic study of the intracellular development of echovirus 22.		1974	4209453
isolation of a specific enhancer for echovirus 6 from uninfected permissive host cells.	a specific enhancer for the m+ variant of echovirus 6 was isolated from uninfected, permissive host cells. the enhancer transferred the susceptibility to virus infection from permissive cells to less susceptible cells. enhancer activity in cultured, human cells (wish) was released by these cells into extracellular fluids at a linear rate. maximal enhancer activity was recovered from cell monolayers that were extracted with buffered salt solutions (ph 6.6) for 5 h at 37 c. crude enhancer preparat ...	1974	4202885
stability of different viruses in a newly developed transport medium.		1974	4362755
acid lability of rhinoviruses: loss of c and d antigenicity after treatment at ph 3.0.		1974	4359785
maintenance of primary african green monkey kidney (pagmk) and vero cells at room temperature (25 degrees). a system for virus isolation in community practice.		1974	4362601
[persistence of viruses on surface areas and use of uv-irradiation in virus disinfection].		1974	4365140
susceptibility of the vero line of african green monkey kidney cells to human enteroviruses.	the relative susceptibility of vero cells and primary rhesus monkey kidney cells to 47 prototype strains of human enteroviruses is described. of these strains, types 4, 14, 16, 17, 18, 21, 31 and 34 and coxsackie virus a 9 failed to cause cpe in the vero cells whilst only one, echovirus type 34, failed to cause cpe in the monkey kidney cells.a comparison is given of the efficiency of the two cell cultures for enterovirus isolation from clinical material. results show that vero cells are as usefu ...	1974	4361500
environmental factors influencing isolation of enteroviruses from polluted surface waters.	the influence of water quality upon the concentration of virus on location was assessed in field studies conducted in the houston ship channel, galveston bay, and houston waste treatment plants. clarification of polluted surface waters was accomplished with minimal loss of virus. virus from clarified sewage effluents and saline waters was then adsorbed and concentrated on textile and membrane filter surfaces. direct measurements of virus from large volumes of polluted surface waters under existi ...	1974	4364463
replication or inactivation of different viruses by human lymphocyte preparations.	cultures of phytohemagglutinin-stimulated, unstimulated, and frozen and thawed mononuclear (as controls) cells from normal human donors were infected with different viruses. a variable pattern of virus infectivity was noted, and influenza and coxsackie virus were rapidly inactivated even by stimulated lymphocytes. direct inactivation by lymphocytes may be one form of host defense in infection by some viruses.	1974	4361296
inactivation of herpes simplex virus by concanavalin a.	the infectivity of herpes simplex virus type 1 (hsv-1) was inactivated after treatment with either concanavalin a (cona) or periodate. phytohemagglutinin, wheat germ agglutinin, pokeweed mitogen, and neuraminidase failed to inactivate the virus. the effect of cona could be specifically inhibited or reversed by the addition of alpha-methyl-d-glucoside or alpha-methyl-d-mannoside. evidence was obtained that hsv-1 inactivated by cona could adsorb to host cells. viral aggregation was not a major mec ...	1974	4364903
natural virus infection in green and cynomolgus monkeys.		1974	4377284
[viruses associated with acute respiratory diseases in children under 10 years in téhéran].		1974	4377806
the development of double-seeded and mixed cell culture systems for use in diagnostic virology.		1974	4365901
comparison of techniques and immunoreagents used for indirect immunofluorescence and immunoperoxidase identification of enteroviruses.	peroxidase-conjugated antibodies were found to be as sensitive as those conjugated to fluorescein-isothiocyanate (fitc) for identification of selected enterovirus types by the indirect technique. peroxidase conjugates, however, were found to give fewer nonspecific reactions. the reasons for the higher specificity of the immunoperoxidase technique appear to be related to the relative size, charge, and uniformity of the preparations. monomers of peroxidase-conjugated globulin are larger than those ...	1974	4366920
viral infections of the central nervous system.		1974	4362722
sensitivity of human diploid embryonic lung cells for isolation of echo viruses from sewage.		1974	4372267
isolation and characterization of an echovirus, possible "prime" strain of echovirus type 12.		1974	4373758
viruses associated with the healthy individual.		1974	4373837
[study of the cultural and karyological characteristics and sensitivity to infection with some viruses, of the 37 rc cell line].		1974	4376673
[letter: meningitis epidemic due to echo 30 (1974) virus].		1974	4459868
[etiologic study of virus infections of the central nervous system in children].		1974	4368129
[studies about the influence of different viruses on the benzo(a)pyrene carcinogenesis (author's transl)].		1974	4369674
bgm, a continuous cell line more sensitive than primary rhesus and african green kidney cells for the recovery of viruses from water.		1974	4369820
concentration of enteric viruses from water with lettuce extract.	a method for recovering enteroviruses, adenovirus, and reovirus from water with lettuce extract is described. lettuce extract at ph 8.5 was added to the sample and the ph was reduced stepwise with hydrochloric acid to 4.0 to 4.5. the flocculent lettuce-extract particles, and adsorbed virus, were readily removed from solution by low-speed centrifugation. electron microscopy suggests that, under conditions suitable for adsorption, virus particles are coated with the lettuce-extract colloid.	1974	4370932
photodistribution of viral exanthems.		1974	4847846
powassan virus infection. a report of three human cases of encephalitis.		1974	4856896
sensitivity of human foetal intestine to interferon.		1974	4810430
rubella reinfection in pregnancy followed by transmission to the fetus.		1974	4823585
febrile illness in early infancy associated with echo virus infection.	twenty-three infants less than six weeks of age with fever of 100.4 degrees f, or higher and no evidence of bacterial infection were seen at the cincinnati general hospital from july to december, 1971. seventeen of these were admitted to the hospital; 15 were treated with penicillin and kanamycin for possible sepsis. viral isolation was attempted on 21 of these infants, and echo viruses were isolated from 14 (66.7 per cent), compared to three (14.3 per cent) of 21 controls. eleven of the 14 echo ...	1974	12119956
a comparative study of agar overlay and standard tissue culture methods for isolation of enteroviruses.	a study was made of the isolation of enteroviruses from 62 cerebrospinal fluids and 141 autopsy specimens with standard fluid monolayer tissue culture methods and tissue cultures under agar overlay with and without added mgcl2 (0.025m). sixteen virus isolations were made only by the overlay method, two only by the standard technique, and six by both procedures. additional studies were carried out on 975 diagnostic specimens of various types with standard tissue culture methods and with primary r ...	1975	163480
[persistence of latex agglutination inhibition antibodies in rabbits following application of poliomyelitis-, coxsackie-, echo- and encephalomyocarditis viruses. brief report].		1975	164163
virus development in enucleate cells: echovirus, poliovirus, pseudorabies virus, reovirus, respiratory syncytial virus and semliki forest virus.	a group of rna viruses, echovirus, poliovirus, reovirus, respiratory syncytial virus and semliki forest virus have been examined for ability to grow in enucleate african green monkey kidney (bsci) cells. semliki forest virus produced an almost normal yield of virus but poliovirus, echovirus, reovirus and respiratory syncytial virus, although showing clear evidence of virus replication when compared with a nuclear dna virus (pseudorabies virus) gave much lower yields than those from nucleate cell ...	1975	163289
role of respiratory viruses in childhood mortality.	respiratory viruses have been identified at necropsy in the lungs of 13 out of 24 children who died with observed acute respiratory illness. the histological appearances of the lungs supported the association between virus and death in each of these 13 children and suggested an unidentified virus aetiology in a further five cases. histological appearances compatible with bacterial infection were found in the lungs of only two of the 24 children. similar virus and histological findings have been ...	1975	163114
[the use of rivanol for the removal of echo virus hemagglutination inhibitors from immune sera].		1975	55945
fatal echo 30 virus infection and amyloidosis in x-linked hypogammaglobulinemia.		1975	45851
the importance of picornavirus infections in respiratory disease of man and other mammals.	picornaviruses may be divided, by physicochemical properties, into enteroviruses, cardioviruses, caliciviruses, rhinoviruses and foot-and-mouth diseases viruses. although the respiratory tract may be the primary site of entry and multiplication for enteroviruses, cardioviruses and fmd viruses, few agents in these groups cause respiratory disease. a notable exception is coxsackievirus a21 which is an important cause of upper respiratory tract diseases in military recruits. the picornaviruses whic ...	1975	165133
organ culture of human aorta: prolonged survival with support of viral replication.	organ cultures were established with use of human fetal aorta obtained after death; cellular elements were preserved in the cultures for periods of up to eight weeks, with maintenance of their in vivo tissue relationships. histologically, these cultures preserve the three coats of the aorta, including an intact endothelial layer cells. the aorta organ cultures supported the replication of echovirus 11, herpes simplex virus type 1, adenovirus 2, and coxsackievirus b5 without the production of det ...	1975	165246
serologic characterization and sero-epidemiologic studies on acute hemorrhagic conjunctivitis (ahc) virus.	serologic and sero-epidemiologic characteristics of ahc virus infection were studied by neutralization test (nt). four-fold or greater virus neutralizing (vn) antibody response was demonstrated to the japanese isolate of ahc virus (the j 670/71 strain) in 77.3% and 66.7% of paired sera from clinical ahc patients in japan (1971-1973) and tunisia (1973). the four patients from indonesia studied in 1972 showed similar antibody response. cross-neutralization tests of ahc virus isolated in japan (197 ...	1975	165719
virus isolation and titration at 33 degrees and 37 degrees c.	various prototype viruses and original specimens were comparatively titrated in cell cultures at 33 degrees and 37 degrees c. higher titers at 37 degrees were consistently obtained with adenoviruses; for other viruses (enteroviruses, herpesvirus hominis, vaccinia virus, parainfluenza viruses) the titers were mostly identical at either temperature. original specimens and prototye strains showed the same behavior. the habit to cultivate viruses from throat swabs at 33 degrees c is unsatisfactory f ...	1975	167268
surveillance of enterovirus infections in bangkok. i. isolation of enterovirus from faecal specimens of healthy children.	during the period august 1970 through july 1973, about 50 faecal specimens collected each month from healthy pre-school children of lower economic status in bangkok were studied for virus isolation using primary monkey kidney cells and new born mice. from a total of 1,823 samples, 557 (30.5%) were positive: 86 (4.8%) polioviruses, 77 (4.2%) coxsackieviruses b, 223 (12.2%) echoviruses, and 127 strains (7.0%) of unidentified viruses. altogether, 45 serotypes of enteric viruses were identified. mor ...	1975	167453
demonstration of virus in groundwater after effluent discharge onto soil.	the survival of virus present in secondary effluents discharged into a cypress dome was studied. isolations were made from concentrates of water drawn from 10-foot (304.80 cm) deep wells. data presented show vertical and lateral virus movement as well as survival within the dome for 28 days during a period of heavy rains when no effluent was being applied. due to the inefficiency of virus concentration procedures, it is proposed that much of the virus present was probably not demonstrated. a rap ...	1975	168809
removal of enteroviruses from sewage by bench-scale rotary-tube trickling filters.	the efficacy of a rotary-tube type of trickling filter for removing coxsackievirus a9, poliovirus 1, and echovirus 12 suspended in raw settled sewage was investigated. at filtration rates equivalent to about 10 mgd (million gallons per day)/acre (ca. 3,785 m3/day per acre), the filters removed 95% of the poliovirus, 83% of echovirus 12, and 94% of coxsackievirus a9. coliform, fecal streptococci, biochemical oxygen demand, and chemical oxygen demand removals were remarkably similar, averaging 94, ...	1975	169731
production of species-unspecific antiviral inhibitors in cell-cultures and in chicken embryos under the influence of pyrazolon derivatives.		1975	169855
[sensitivity of various primate cells and animal viruses to the antiviral activity of human leukocyte interferon (author's transl)].	u cells (a permanent, human amnion cell line) were protected against infection with semliki forest virus (sfv) by human interferon (hif) from peripheral leukocytes. despite the usual genus-specific action of interferons, mouse l929 cultures (a permanent mouse fibroblast cell line) were also protected by hif. the antiviral action of hif in six other primate cell cultures was also examined. it is of interest that two lymphoblastoid cell lines, rpmi1788 and kaplan, were insensitive to hif. the sens ...	1975	170886
[effect of sodium salicylate on the "in vitro" development of rna viruses (author's transl)].	sodium salicylate 10(-3) m is able to limit the number of plaques induced by rna viruses on monkey kidney cell cultures (cercopithecus aethiops and macaccus rhesus). however, the inhibition rate changes with the virus type or even the strain used. poliovirus 2, coxsackie b3, echovirus and reovirus 1 were the most susceptible to the inhibitory effect of the drug. latent infection caused by sv5 decreases the antiviral activity of salicylate. the stages of the poliovirus type 2 growth affected by s ...	1975	171988
studies on the survival and fate of enteroviruses in an experimental model of a municipal solid waste landfill and leachate.	in laboratory scale municipal solid waste lysimeters containing simulated refuse, and seeded with either laboratory or field strains of poliovirus type 1 and echovirus type 7, viruses were not detected in the lysimeter leachate produced over a 4-month period. in addition, viruses were detected in the lysimeter refuse contents after termination of lysimeter operation. these results appeared to be due to virus retention in the lysimeter caused by virus adsorption and virus inactivation. evidence f ...	1975	172012
[respiratory tract infections of viral origin in infants. examination of 103 serum pairs in autumn and following spring].	in autumn 1973 und about four months later in spring 1974 blood samples were taken from the same 103 children aged from a few months to five years and coming from different parts of bavaria. we examined the samples for complement-fixing antibodies against the influenza virus types a, b and c, the parainfluenza virus types 1, 2 and 3, the adenoviruses and the respiratory-syncytial virus, and for neutralising antibodies against the echo virus type 25. at the commencement of the investigation the m ...	1975	172769
a high density component in several vertebrate enteroviruses.	in addition to the major infective component, which bands at a density of 1:34 g/ml in caesium chloride ("light component"), a component with a density of 1:44 g/ml ("heavy component") has been found in harvests of poliovirus (type i), coxsackie b5 virus, a bovine enterovirus (vg-5-27) and swine vesicular disease virus (svdv). with svdv about 98% of the infectivity equilibrated at 1 . 34 g/ml but approx. 2% was present as a peak at 1 . 44 g/ml. the morphology of the two forms was similar but the ...	1975	213532
development of a simple method for concentrating enteroviruses from oysters.	the development of a simple method for concentrating enteroviruses from oysters is described. in this method viruses in homogenized oyster tissues are efficiently absorbed to oyster solids at ph 5.5 and low salt concentration. after low-speed centrifugation, the supernatant is discarded and viruses are eluted from the sedimented oyster solids by resuspending them in ph 3.5 glycine-buffered saline. the solids are then removed by low-speed centrifugation, and the virus-containing supernatant is fi ...	1975	234154
virologic and serologic studies on an outbreak of echovirus type 11 infection in a hospital maternity unit.	an outbreak of echovirus type 11 (e-11) infection occurred among newborn babies in a hospital maternity unit in the summer of 1971. the results of studies are as follows: 1) forty-one of 188 infants developed febrile illness with stomatitis during one and a half months from july to september. e-11 was isolated from stool specimens of 14 infants and two throat swabs. antibody response to the virus was shown in all the 19 cases examined. some of their mothers were suffering from subclinical infect ...	1975	1195517
electrophoretic analysis of capsid and non-capsid polypeptides of echovirus 12, and selective inhibtion of the formation of virus particles by actinomycin d.	electrophoretic analysis of purified echovirus virus particles yielded four polypeptides of mol. wt. 37000, 30000, 25000 and 7600. the 75s empty capsids of echovirus 12 lack the 25000 and 7600 mol. wt. polypeptides, and possess polypeptides of 41000 mol. wt. a total of 14 virus-induced polypeptide species was found in the cytoplasm of infected cells. actinomycin d reduced the synthesis of virus, virus rna, and virus polypeptides and also reduced the proportion of virus particles to empty capsid ...	1975	1168242
[the value of the coxsackie b virus complement fixation test (author's transl)].	enteroviruses were isolated from 27 patients during 1973 and 1974, 21 of these were coxsackie b, 4 were echo and 2 were polio viruses, 5 further viruses could not be identified. sera from 14 of the coxsackie patients were investigated twice by means of the complement fixation test (cft). 11 of them showed a significant rise in antibody titre against one of the 6 different coxsackie b viruses. no strong correlation was established between the result of the cft and the isolated type of virus. neve ...	1975	1226771
studies on some biological properties of heteroploidal cell -- pzh-1 line derived from human embryo lung.	the morphological and karyological properties as well as susceptibility to virus strain of tissue culture derived from human embryo lung that underwent a transformation becoming a continuous line defined as pzh-1 were observed. the observations cover 120 passages divided into four phases: one before and three after transformation. each of these phases was characterised by different biological strain properties. loss of pzh-1 susceptibility to echo virus was the first change of biological propert ...	1975	1211221
an epidemic of echovirus 18 meningitis.	the first reported outbreak of echovirus 18 meningitis in the united states occurred during the summer of 1972 in durham, north carolina. one hundred three cases of aseptic meningitis were seen at duke university medical center over a period of four months. most of the patients were less than 25 years old, black, and residents of durham county or nearby counties.. symptoms included headache (92%), fever (76%), nuchal rigidity (67%), and nausea and/or vomiting (51%). in contrast to previously pub ...	1975	1167369
electron microscopic study of the morphogenesis of echovirus 23.		1975	803900
a comparative study of meningoencephalitis epidemics caused by echovirus type 7 and coxsackievirus type b5. clinical and virological observations during two epidemics in northern sweden.	two epidemics of meningoencephalitis caused by echovirus type 7 and coxsackievirus type b 5 in the summer and autumn of 1973 in umeå in northern sweden were compared. most patients with echovirus 7 meningoencephalitis were neck stiff and 50% had a polymorphonuclear pleocytosis in the cerebrospinal fluid (csf). the illness was usually mild. it appears to be the first time that an epidemic caused by this virus is described from scandinavia. on the other hand most patients with coxsackievirus b 5 m ...	1975	1209167
enterovirus infections in neonates.	twenty-seven ill neonates with enterovirus infections were studied to learn if enterovirus infection can be distinguished from neonatal sepsis. enterovirus infection was associated with the summer-fall season (93%), recent maternal illness (59%), absence of other perinatal problems (81%), and findings of fever (93%), viral meningitis (62%), diarrhea (81%), and rash (41%). four children developed thrombocytopenia and three necrotizing enterocolitis. three children died, all with coxsackie b virus ...	1976	978329
acute myopathy in three brothers.	three brothers are reported who presented simultaneously with acute myopathy, which resolved rapidly. muscle biopsy showed vacuolar degeneration, with no inflammatory changes. an echo virus was grown from the stools of two of them. their course, together with that of a fourth brother, who had an acute illness with rash, lymphadenopathy and splenomegaly, suggests a possible viral aetiology.	1976	988912
enterovirus infections in acute pancreatitis - a possible etiological connection.	all patients admitted with a preliminary diagnosis of acute pancreatitis during a one-year period were subjected to virus investigations. 142 patients were included in the study and of these 91 were found to have acute pancreatitis. evidence of enteroviral infection was found in 18 of the 91 patients (19.8 per cent). from 17 of the 18 patients enterovirus was isolated from feces or urine, and in one a significant titer rise (cf-test) against coxsackie virus b5 was found. a significant titer rise ...	1976	996429
inhibition of echovirus-12 multiplication by n-carbobenzoxy-d-glucosamine.	the glucosamine derivative, n-carbobenzoxy-d-glucosamine (ncbzg) inhibits the multiplication of echovirus-12 and the synthesis of both virus rna and protein at a stage in the virus growth cycle after attachment and penetration. however, the compound does not inhibit virus multiplication after the appearance of progeny virus nor after virus rna has accumulated. incorporation of radioactive glucosamine and choline into infected and uninfected cultures is inhibited by ncbzg as is the virus-induced ...	1976	1003167
[viral myocardium pericarditis. study of 11 cases].		1976	1031035
severe echo 19 virus infection in a neonatal unit.	an epidemic of echo 19 virus infection in a neonatal unit affecting 12 babies with one death is described. with one exception it was confined to the neonatal unit and medical and nursing staff were also affected. the unit was closed for 9 days, then was disinfected, and there was no recurrence.	1976	962375
myocarditis associated with echo type 7 infection in a leukemic child.	a 3 1/2-year-old boy, during the course of acute lymphocytic leukemia presented clinical, roentgenological and ecg signs of myocarditis, which disappeared completely within 1 1/2 month. echo type 7 virus was isolated from the faeces during the acute stage of the disease and rise in echo 7 neutralizing antibodies was demonstrated in paired sera of the patient. this unusual pathogenicity of echo 7 virus could be explained with the impairment of the host resistance induced by leukemia and immunosup ...	1976	1066956
epidemic of echovirus 19 in the north-east of england.	we report the first large-scale outbreak of echovirus 19 infection. it occurred in the north-east of england during the summer and autumn of 1974. the virus was isolated from 268 patients in the region. the infection spread from the urban to more rural areas, reaching a peak in mid-august. males were affected more often than females in the ratio 1-6:1. half of the patients were under eight years of age, relatively few were over 35 years. aseptic meningitis and upper respiratory infections were t ...	1976	1063219
[permissivity of mouse-man hybrid cell clones to three enteroviruses: poliovirus ii, coxsackie b3 and echovirus 11. role of human chromosome f. 19 (author's transl)].	the permissivity of human cells to enteroviruses is linked to the presence of specific cell receptors. owing to the chance elimination of human chromosomes, the man-mouse hybrid cells may be permissive or not depending on the genome responsible for synthesis of the receptors, and whether it has been conserved or not. by comparison of the cytopathogenic effects and virus production after inoculation of the viruses polio ii, echo 11 and coxsachie b3 to various hybrid strains, we observed an identi ...	1976	180477
demonstration of solids-associated virus in wastewater and sludge.	data presented demonstrate the relatively high multiplicity of solids-associated virus in field samples, i.e., wastewater, sludge, and soils. influent, effluent, and chlorinated effluent samples showed 16.1 to 100% of the total virus demonstrated in samples to be solids associated. three techniques for freeing solids-associated virus are described and compared. using sonication of solids and polyethylene glycol concentration, virus was demonstrated in fully digested sludge (60 days at 34 c), san ...	1976	180882
stability of human enteroviruses in estuarine and marine waters.	studies of the effects of temperature and salinity on the survival of three enteric viruses (poliomyelitis type 1, echovirus-6, and coxsackievirus b-5) under controlled laboratory conditions and in situ indicate that temperature rather than salinity is the critical factor affecting their stability, in that the higher the temperature the more rapid was the loss of viral infectivity. in the laboratory studies, all three viruses were quite stable at 4 degrees c, with infectious virus still detectab ...	1976	184736
[hand, foot and mouth disease].	two characteristic cases encountered in young adults led the authors to present the hand foot and mouth syndrome. they report the characteristic distribution and vesicular appearance of the lesions. the course was benign. the viral origin of the disease was more or less easily confirmed by cell culture, inoculation in new born mice and demonstration of antibodies. usually the virus was a coxackie a 16. however in one of the authors cases, an echo 11 was demonstrated. the apparent rareness of the ...	1976	186899
detection of virus in water: sensitivity of the tentative standard method for drinking water.	the sensitivity of several microporous virus-adsorbent media for reliably detecting low levels of poliovirus from 380 and 1,900 liters of drinking water by use of the tentative standard method was investigated. the virus-adsorbent media tested were (i) nitrocellulose membrane filters, (ii) epoxy-fiber glass-asbestos filters, (iii) yarn-wound fiber glass depth filters, and (iv) epoxy-fiber glass filter tubes. virus was adsorbed to the filter media at ph 3.5 and eluted with glycine buffer, ph 11.5 ...	1976	187116
enteroviruses other than poliovirus.	the role of enteroviruses in certain specific disease--cardiac disease, nephritis, diabetes, and hemorrhagic conjunctivitis--is examined. it has now been well documented that coxsackievirus b (types cb1 through cb5 but not cb6) is the main pathogen involved in various clinical forms of viral heart disease. coxsackievirus a (ca4 and ca16) and echovirus (types 9 and 22) may also be associated with viral heart disease. in regard to the etiologic role of enteroviruses in nephritis, pancreatitis, and ...	1976	193602
effect of acid ph, salts, and temperature on the infectivity and physical integrity of enteroviruses.	at 2 degrees and 30 degrees c, enteroviruses are more stable on the acid than on the alkaline side of neutrality. in the range from ph 3 to 9, temperature is so influential that the fastest inactivation rate at 2 degrees c is slower than the slowest inactivation rate at 30 degrees c. specific ions or salts also affect the rate of inactivation of enteroviruses. nacl and other chloride salts enhance the inactivation of poliovirus at ph 3. nacl is considerably less effective against poliovirus in t ...	1976	13766
virus inactivation by grapes and wines.	infusions and extracts of different grapes inactivated poliovirus; agents responsible for this property resided in the skin of the grape. commercial grape juice at both natural and neutral ph inactivate various enteric viruses and herpes simplex virus; a 1,000-fold reduction in poliovirus infectivity occurred after incubation with grape juice, ph 7.0, for 24 h at 4 degrees c. a variety of wines were antiviral but to a lesser extent than grape juice; red wines were more antiviral than white. anti ...	1976	12719