Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| a study of coxsackie b virus infections, 1972-1983. | the results of a twelve-year study of coxsackie b virus (cbv) infections in patients with a variety of acute and chronic illnesses are reported. cbvs were isolated from only 123 patients most of whom were children with respiratory illness. virus diagnosis in adults was based mainly on the detection of significant rising or static high neutralizing antibody titres. between 1972 and 1979 most investigations centred on patients with suspected viral heart disease, 12% of whom were found to have diag ... | 1984 | 6094660 |
| reverse radioimmunoassays of igm and igg antibodies to coxsackie b viruses in patients with acute myopericarditis. | a reverse radioimmunoassay (ria) of antibodies to enteroviruses, previously developed for the detection of igm antibodies to coxsackie b1 (cb1) and b3 (cb3) and to echo 11 (e11) and 30 (e30) viruses, was extended in the present study for the detection of igm antibodies to coxsackie b2 (cb2), b4 (cb4), and b5 (cb5) viruses and of igg antibodies to cb1-cb5, e11, and e30 viruses. after standardisation of the assays and application to a collection of serum specimens from patients with proven enterov ... | 1984 | 6094719 |
| murine forebrain anomalies induced by coxsackievirus b3 variants. | neonatal or 7-day-old mice inoculated intracranially with either of two temperature-sensitive mutants (ts1, ts6) or the parent coxsackievirus b3 (cvb3) subsequently developed porencephaly or hydranencephaly. the forebrain anomaly induced depended upon age of the animal at inoculation and virus variant inoculated. sections of brains from hydranencephalic mice revealed severe meningeal reactions, necrotizing encephalitis, and liquifactive necrosis in the cerebrum. no pathology was found in the pon ... | 1984 | 6096503 |
| [possible relations between viral myocarditis and dilated cardiomyopathy (congestive)]. | 1984 | 6096936 | |
| [retrospective study of coxsackie b virus infections and congestive cardiomyopathy]. | thirty patients with congestive cardiomyopathy (c.c.) have been studied for the prevalence of neutralizing antibodies to coxsackie b viruses in comparison with age and sex matched controls. seropositivity toward each antigen was similar in cases and controls: an exception was coxsackie b5 virus, where a significantly seropositivity was found in the control group. as a whole, high antibody titers to any antigen were observed more frequently on sera of cardiopathic patients; however the difference ... | 1984 | 6097290 |
| [myocarditis caused by coxsackie b viruses in adults]. | two hundred and thirty-eight patients with a clinical and electrocardiographic diagnosis of myocarditis and two control groups were examined for virus-neutralizing antibodies against coxsackie b1-6 viruses. serological evidence for preceding coxsackie infection was demonstrated by 40.9% of myocarditis and in 29.3% of myopericarditis patients. coxsackie b2 and b4 viruses were the most prevalent. the patients manifested a significant increase in the antibody titer as compared with the control grou ... | 1984 | 6098043 |
| [coxsackie b4 virus murine myocarditis]. | 1984 | 6098385 | |
| [adipose tissue as a target organ of infection with coxsackie virus b3: detection of viral antigens by immunofluorescent technique]. | 1984 | 6099627 | |
| quantitative evaluation of the effects of disinfectants against viruses in suspension experiments. | time concentration relations in virus-disinfection by formaldehyde, benzalkonium-chloride, ethanol and isopropanol are evaluated. the exposure time needed to reduce the number of plaque-forming units (pfu) by 10(-3) (99.9%) at a given disinfectant concentration was determined. influenzavirus, coxsackie b viruses, herpesvirus and mumpsvirus were used in the experiments. formaldehyde is effective at very low concentrations, provided that sufficient time is allowed for reaction, but has little use ... | 1984 | 6099667 |
| the relationship of myocarditis to dilated cardiomyopathy. | three patients with congestive cardiomyopathy are reported in whom high neutralizing antibody titres to coxsackie b viruses were detected. at post-mortem examination, all three had histologically demonstrable chronic inflammation of the myocardium. the hearts of ten patients dying in cardiac failure due to other causes showed no comparable inflammatory infiltration. this provides further evidence that coxsackie b viral myocarditis is involved in the pathogenesis of some cases of dilated cardiomy ... | 1984 | 6100098 |
| [coxsackie b5 infection in a newborn infant. meningoencephalitis and myocarditis]. | a coxsackie virus b5 was isolated from a neonate with aseptic meningitis and myocardial dysfunction. this infection is probably acquired in utero: a high level of specific antibodies was found in the mother and the titer increase later on. at 34 months the baby is totally free of sequelae. | 1984 | 6100130 |
| antibodies against coxsackie b2 virus in infants and children in delhi. | 1984 | 6100184 | |
| insulin-dependent diabetes: a possible viral disease. | the available information regarding the possible relevance of viruses in the pathogenesis of insulin-dependent diabetes is reviewed. experimental studies in animals, clinical cases, histopathologic findings as well as epidemiologic and family studies provide circumstantial evidence that at least some cases of the disease are triggered by infection. moreover, since it is widely accepted that autoimmunity plays a key role in diabetogenesis, the possible relationship between viruses and the inducti ... | 1983 | 6100819 |
| [the kinetics of coxsackie b virus interaction with natural clay minerals]. | 1983 | 6101073 | |
| diabetes and coxsackie virus b5 infection. | 1980 | 6101692 | |
| coxsackie-b-virus-specific igm responses in patients with cardiac and other diseases. | an enzyme-linked immunosorbent assay (elisa) test using polyvalent antigens and antisera was developed to detect coxsackie-b-virus-specific igm responses. the sera of 24 of 64 (37.5%) patients with acute pericarditis and 14 of 38 (36%) with acute myocarditis were positive for coxsackie-b-virus-specific igm. 4 of 30 (13.3%) patients with acute ischaemic heart disease and 2 of 28 (7.1%) patients with congestive cardiomyopathy were also positive. coxsackie-b-virus-specific igm was detected in the s ... | 1980 | 6107769 |
| the search for antiviral agents among corynebacteria. | extracts of strains of corynebacterium diphtheriae var. mitis avirulent, c. hofmannii, c. xerosis, c. parvum and an unidentified corynebacterium species were tested for antiviral activity against laboratory strains of echovirus type 11, adenovirus type 2 and vaccinia, and a recent isolate of herpes simplex virus. unlike a previous study, no appreciable antiviral activity was detected in the extracts tested | 1980 | 6108068 |
| ultrastructural degenerative changes of age-dependent echo 9 virus-induced polymyositis in infant mice. | experimental inoculation of newborn nmri mice with echo virus, type 9, strain a. barty *echo 9 virus ab) resulted in diffuse polymyositis 4 days later. the disease, after a delay of 1 day, increased in intensity and was accompanied by a rapid, progressive paresis leading to death 7-11 days following infection. as early as 24-48 h after inoculation, we detected initial ultrastructural degenerative changes, characterized by segmental dilation fo the sarcoplasmic reticulum. disruption and breakage ... | 1981 | 6112816 |
| comparative cytogenetic study of a continuous human cell line and its subline susceptible and resistant, respectively, to coxsackie b3 virus. | cytogenetic characteristics of the j-96 human cell line and its j-41 subline, highly susceptible and resistant, respectively, to coxsackie b3 virus, were compared. the j-41 subline, as compared to the original j-96 line, had fewer chromosomes in the modal class cells (54-57 and 58-62, respectively) mostly at the expense of normal chromosomes. in most j-41 cells chromosome 21 was eliminated and the number of homologues of chromosomes 2, 9, 11, and 12 was reduced. the percentage of marker chromoso ... | 1981 | 6112861 |
| coxsackie b virus infection associated with hypoparathyroidism in a neonate. | 1982 | 6129479 | |
| coxsackie-b-virus-specific igm responses in children with insulin-dependent (juvenile-onset; type i) diabetes mellitus. | coxsackie b1-6 virus igm responses were detected by an enzyme-linked immunosorbent assay (elisa) in 11 of 28 (39%) children aged 3-14 years in whom insulin-dependent (juvenile onset; type i) diabetes mellitus (iddm) developed in 1982. 5 patients had a homotypic response to coxsackie b4 and 1 had a homotypic response to b5. a serum sample had been obtained from each patient 2 to 16 weeks after onset of iddm symptoms. islet-cell cytoplasmic antibodies (igg) and complement fixing islet cell antibod ... | 1983 | 6134178 |
| antiviral activity of aryl-furfurane derivatives. | of 27 aryl-furfurane derivatives (afd) studied, 13 compounds were found to have antiviral activity against echo 6, herpes simplex, vaccinia, and influenza a/hong kong/1/68 (h3n2) viruses, the highest inhibition being observed with echo 6 virus. the maximum tolerated concentrations (matc) of afd inhibited the macromolecular syntheses in echo 6 virus-infected cell cultures. | 1984 | 6143495 |
| persistence of coxsackie b1 virus in balb/c mice. | 1984 | 6148863 | |
| pathogenicity of newly isolated coxsackievirus b4 for mouse pancreas. | coxsackievirus b4 fresh isolates from patients with upper respiratory illness and aseptic meningitis were studied for their pathogenicity in the pancreas of sjl/j mice. out of 12 virus isolates, 7 induced hypoglycaemia in mice 2 to 4 days after virus inoculation. all 3 isolates from faeces of patients induced hypoglycaemia in contrast to 3 viruses isolated from the cerebrospinal fluid which did not. six isolates from throat swabs were either pathogenic (4 isolates) or non-pathogenic (2 isolates) ... | 1984 | 6151359 |
| inhibitory activity of 2-aminooxazole derivatives against coxsackie b1 virus in fl cells. | the antiviral activity of three-2-aminooxazoles was studied against coxsackie b1 virus in fl cells. the virus-induced cytopathic effect was nearly completely suppressed by two of the test compounds as revealed by spectrophotometric turbidity measurements. the plaque reduction amounted to 95--100 per cent. the compounds had no effect on extracellular virus or on absorption and penetration. the inhibition of infectious virus yield in one-step growth experiments reached 94--99.9 per cent. one of th ... | 1980 | 6158853 |
| immunological studies of the group b coxsackieviruses by the sandwich enzyme-linked immunosorbent assay (elisa) and immunoprecipitation. | a microplate double antibody sandwich elisa was employed in an immunological study of the group b coxsackieviruses. the assay, described in detail, detected high dilutions of virion antigen (less than 10 ng) in purified preparations and in crude infected cell extracts. furthermore, by using a constant amount of antigen, group b virus antibodies in hamster antisera could be quantified with a sensitivity equivalent to the virus neutralization test. titrations of virus antigens and antibodies were ... | 1980 | 6161989 |
| [stability of c-band heterochromatin polymorphism in 2 transplantable human cell lines differing in sensitivity to coxsackie virus b3]. | heterochromatin of chromosomes is studied by means of a c-banding technique for the j-96 line of human cells, which is susceptible to enteroviruses and for the j-41 cell line derived from this culture and possessing high specific resistance to coxsackie b viruses. the data obtained demonstrate stability of variform c-heterochromatin of chromosome pairs 1, 9 16 and certain marker chromosomes in the course of long-term cultivation. | 1981 | 6165117 |
| two cases of viral myocarditis and one case of viral pericarditis. | two cases of myocarditis, who had suffered from ventricular extrasystole, leucocytosis and elevated serum enzyme for a long period died from congestive heart failure and/or arrhythmias. the biopsy specimens from the right ventricle in one of them showed a positive reaction against coxsackie b virus (1, 3, 4 and 5) in the fluorescent antibody method. one case of virus pericarditis had 5 recurrences over a five-year period. he suffered from dyspnea, chest oppression and general fatigue at each rec ... | 1982 | 6182311 |
| [seroepidemiology of infections by coxsackie group b virus, types 1-6, herpes simplex virus, and lymphocytic choriomeningitis virus in a population of healthy adults and children. cf reaction using dextran t 70 as an adjuvant]. | 1981 | 6182843 | |
| high frequency of antigenic variants among naturally occurring human coxsackie b4 virus isolates identified by monoclonal antibodies. | 1982 | 6183593 | |
| specificity of igm antibodies in acute human coxsackievirus b infections, analysed by indirect solid phase enzyme immunoassay and immunoblot technique. | the specificity of the igm response in acute human coxsackievirus b infections was examined by indirect solid phase enzyme immunoassay and immunoblot techniques. igm antibodies detected by elisa were either strictly type-specific, type-predominant or group-reactive to coxsackieviruses b-1 to b-5. homotypic and type-dominant responses were clearly correlated with the serotype isolated from the patient. analysis of elisa antigens by sds-gel electrophoresis, protein transfer and subsequent immunode ... | 1983 | 6185632 |
| heterogeneity of a human isolate of coxsackie b4: biological differences. | evidence is presented to demonstrate existence of virion heterogeneity within the human isolate, edwards, of coxsackievirus b4 (cb4-edw). three virion types (e1, e2 and e3) were cloned by repeated plaque purification of cb4-edw and then all were compared relative to their effects on the pancreas of mice during acute infection. seventy-two hours post-infection blood glucose, plasma amylase and insulin levels were monitored in mice of the swr/j strain (previously classified susceptible to other di ... | 1983 | 6193205 |
| type-specific and cross-reactive antigenicity of capsid proteins vp1 and vp2 of echovirus type 7. | after disruption of echovirus type 7 virions with urea and heat, vp1 and vp2 were separated by isoelectric focusing in urea-containing sucrose gradients. antisera to these two polypeptides were produced in guinea pigs. in complement fixation, antiserum to vp1 reacted with native and heated virions (n and h antigens, respectively) of homologous virus, and also cross-reacted with heated virions of some other enteroviruses used. antiserum to vp2 was reactive only with heated virions of homologous a ... | 1983 | 6199652 |
| monoclonal antibodies for study of antigenic variation in coxsackievirus type b4: association of antigenic determinants with myocarditic properties of the virus. | monoclonal antibodies were produced to a field strain ( mil ) of group b coxsackievirus type 4 (cbv-4), and to the prototype jvb strain. nine were neutralizing antibodies and four were non-neutralizing antibodies with virus-specific activity in indirect immunofluorescence (if) staining. on the basis of reactivity with the panel of monoclonal antibodies, nine different strains of cbv-4 were found to fall into five distinct antigenic groups. antigenic variants were produced by using the neutralizi ... | 1984 | 6202831 |
| influence of input multiplicity of infection on the antiviral activity of interferon. | the antiviral activity of interferon was shown to be dependent on the input m.o.i. cells could not be protected against the cytopathogenic effect of vaccinia, herpes, echo or vesicular stomatitis virus at m.o.i. greater than 1. at a m.o.i. of less than or equal to 1, cells could be protected but the amount of interferon necessary to yield protection was inversely related to the m.o.i. when protection was afforded, it was only transient. the duration of the antiviral effect of interferon was also ... | 1980 | 6243342 |
| stability of simian rotavirus in fresh and estuarine water. | the rates of inactivation of poliovirus 1, echovirus 7, coxsackievirus b3, and simian rotavirus sa11 were compared in polluted and nonpolluted fresh and estaurine water samples. the study was done in two parts, comparing virus survival in samples taken 1 year apart from the same sites. the survival studies were performed at 20 degrees c and at the natural ph of the water samples. in the first part of the study, the time required for a 3-log10 reduction in the initial virus titers was 2 to 3 days ... | 1980 | 6243899 |
| technetium-99m pyrophosphate uptake in experimental viral perimyocarditis. sequential study of myocardial uptake and pathologic correlates. | the myocardial uptake of technetium-99m pyrophosphate (99mtc-pyp) in perimyocarditis induced by coxsackievirus b3 in balb/c mice was studied. 99mtc-pyp uptake ratio, measured by the ratio of counts/min per gram for the heart to counts/min per gram for the skull, began to increase 5 days after virus inoculation when myocardial necrosis was evident. on the seventh day after the inoculation, 99mtc-pyp ratio reached a maximum. histologically, fine, dystrophic calcification appeared in the necrotic f ... | 1980 | 6244121 |
| improvement of enterovirus neutralization by treatment with sodium deoxycholate or chloroform. | enterovirus strains which could be neutralized only partially or not at all by specific antiserum were readily accessible to the antibodies after treatment with sodium deoxycholate or chloroform. the latter treatment is simple and can be performed with crude virus suspensions of low titer. the method was particularly successful for routine typing of enterovirus 71 and coxsackievirus types a7 and a16. | 1980 | 6244237 |
| clinicopathological study of coxsackie b viral myocarditis. | autopsy cases of myocarditis caused by coxsackie viruses in two infants, aged 5 years and 10 months and 12 years, and two adults, aged 24 years and 45 years, were presented. of the four cases, three revealed a rise in serum neutralization titer to cox b,4 virus and one to both cox b2 and cox b4 viruses. compared with the adult cases, the 2 infant cases showed less inflammatory response with relatively prominent hypertrophy in the heart. both of the adult cases revealed intensive inflammatory rea ... | 1980 | 6244712 |
| the role of host genetics in the pathogenesis of coxsackievirus infection in the pancreas of mice. | the susceptibility of mice to the diabetogenic effect of the m variant of encephalomyocarditis (memc) virus is probably inherited as a recissive trait. three strains of mice that were susceptible to memc virus, three strains that were not susceptible to memc virus, and three types of f1 hybrid strains were infected with the common human coxsackie virus, group b, type 4 (cb4). they were examined to determine the titer of virus and histochemistry in the pancreas, levels of blood glucose, urinalysi ... | 1980 | 6245147 |
| coxsackie b2 virus isolation from a case of postnatal meningoencephalitis. | clinical, morphopathological and virological data are presented with reference to a fatal case of postnatal meningoencephalitis from which a coxsackie b2 virus strain could be isolated. the lesions consisted mainly in a meningeal inflammatory process with fibrocytes, a few lymphocytes and rare polynuclear cells. marked stasis, diffuse and perivascular infiltrates with lymphcoytes and polynuclear cells, as well as lympho-glial nodules were observed in the brain parenchyma. | 1980 | 6246681 |
| influence of estuarine sediment on virus survival under field conditions. | the survival of poliovirus 1 (lsc) and echovirus 1 (farouk) in estuarine water and sediment was studied in galveston bay, texas. viruses were suspended in estuarine water and sediment both in dialysis tubing and in chambers constructed with polycarbonate membrane walls. virus inactivation rates in seawater were similar in both types of chambers. virus adsorption to sediment greatly increased survival time. the time required to inactivate 99% (t-99) of poliovirus increased from 1.4 days in seawat ... | 1980 | 6246838 |
| poliomyelitis-like illness associated with asthma. | a 10-year-old girl with a combination of paralytic disease, resembling poliomyelitis, and asthma is described. the girl developed neurological symptoms 5 days after a severe attack of asthma. no aetiology to the flaccid paralysis could be demonstrated although coxsackie b5 virus was isolated from a stool. a similar poliomyelitis-like illness associated with asthma has previously been reported in 13 cases from australia and the uk. | 1980 | 6246842 |
| coxsackie b virus antibody responses in juvenile-onset diabetes mellitus. | a prospective serological study of patients with recently diagnosed juvenile-onset diabetes mellitus was carried out to determine neutralizing antibody responses to coxsackie b viruses. the sera were tested with and without staphylococcal protein a absorption, to selectively ascertain whether specific igm or igg antibody predominated. of eleven patients studied, ten had reciprocal antibody titres of sixteen or greater to at least one serotype. three patients showed no reduction in titre in at le ... | 1980 | 6247107 |
| indirect enzyme-linked immunosorbent assay (elisa) for the detection of coxsackievirus group b antibodies. | an indirect, solid phase, microplate enzyme-linked immunosorbent assay (elisa) was found to be highly sensitive and reliable for detecting antibodies to the group b coxsackieviruses and other picornaviruses. conditions for obtaining maximum sensitivity and reproducibility of the indirect elisa are described. antibody titres were comparable to those obtained by the virus neutralization test and over 50 times higher than those obtained by the complement-fixation test. purified virions used in the ... | 1980 | 6247437 |
| [experimental nephritis induced by cox. b4 virus in mice (author's transl)]. | 1980 | 6247529 | |
| [myopericarditis caused by coxsackie b virus]. | 1980 | 6247662 | |
| [restoration of the sensitivity of cells resistant to coxsackie b3 virus after treatment with sensitive cell filtrate]. | the study was done with j-96 cell line sensitive to coxsackie b3 virus and the subline j-41 derived from it and resistant to this virus. in order to determine the substrates responsible for the susceptibility or resistance of these cells to coxsackie b3 virus, homogenates and filtrates of the susceptible cells were inoculated into resistant ones and vice versa. inoculation of the resistant cell homogenates into the susceptible cells at various intervals after virus inoculation did not inhibit vi ... | 1980 | 6247850 |
| evaluation of various soil water samplers for virological sampling. | two commercially available soil water samplers and a ceramic sampler constructed in our laboratories were evaluated for their ability to recover viruses from both tap water and secondary sewage effluent. the ceramic sampler consistently gave the best recoveries of viruses from water samples. soil columns containing ceramic samplers at various depths provide a simple method for studying virus transport through sewage-contaminated soils. | 1980 | 6247976 |
| [case of coxsackie virus infection with multiple organ involvement]. | 1980 | 6249044 | |
| detection of enterovirus specific igg and igm antibodies in humans by an indirect solid phase radioimmunoassay. | the development of a solid phase radioimmunoassay which is able to detect virus-specific igg and igm antibodies in serum specimens from patients with enterovirus infections is described. viral antigen partially purified from infected tissue culture fluid was absorbed passively to individual polystyrene microtiter wells. dilutions of sera were incubated on these antigens and bound anti-viral antibodies were monitored by the addition of 125-iodine labeled anti-human-igg or anti-human-igm antibody. ... | 1980 | 6250017 |
| virus infections of the myocardium. | 1980 | 6250138 | |
| [viruses and the kidneys]. | 1980 | 6250241 | |
| [diagnostic value of detecting neutralizing antibodies to coxsackie b enteroviruses in patients with infectious-allergic myocarditis]. | the clinical virological survey of 180 cardiological patients aged 16-60 years with clinically diagnosed infectious allergic myocarditis (100), rheumatism (38) and other cardiac diseases (42) was made. a group of 97 practically healthy adults aged 21-60 years was used for control. the survey revealed statistically significant differences in the frequency of occurrence of coxsackie b virus in healthy persons and in cardiac patients. thus the criteria of the diagnostic significance of the results ... | 1980 | 6250306 |
| survival of human enteroviruses in the hawaiian ocean environment: evidence for virus-inactivating microorganisms. | the stability of certain human enteroviruses in the hawaiian ocean environment was examined. the present data indicated that the time for 90% reduction of poliovirus type 1 at 24 +/- 1 degree c in seawater samples obtained from different sites in hawaii ranged from 24 to 48 h, and complete inactivation occurred within 72 to 96 h. the accumulated evidence also strongly indicated that a virus-inactivating agent(s) of a microbiological nature was present in both clean and sewage-polluted seawaters, ... | 1980 | 6250472 |
| [effect of different doses of diphtheria exotoxin on the properties of l929 and hela cells]. | various forms of interaction between diphtheria exotoxin and the continuous l and hela cell lines were revealed, depending on its doses: toxic, subtoxic and small (following the subtoxic dose). cells of the same origin, treated with these doses, develop similar changes in some of their properties, differing only in their "survival" time, the period of adaptation and the time of entering the phase of active proliferation. the systems of cells, having simultaneously low susceptibility to infection ... | 1980 | 6251678 |
| coxsackie virus b3 perimyocarditis in balb/c mice: experimental model of chronic perimyocarditis in the right ventricle. | severe perimyocarditis was induced in weanling balb/c mice inoculated with coxsackie virus b3 (nancy strain). yellowish-white patches were seen only on the surface of the right ventricle of the heart on the 7th to the 180th day after the inoculation. more than half the animals were affected. following myocardial degeneration and necrosis, mononuclear cell infiltration was evident on the 7th day. after the 28th day, perimyocardial fibrosis increased and cellular infiltration gradually decreased. ... | 1980 | 6253611 |
| residual pathologic changes and 99mtechnetium pyrophosphate uptake following coxsackievirus b3 perimyocarditis in mice. | the myocardial uptake of technetium-99m pyrophosphate (99mtc-pyp) in perimyocarditis induced by coxsackievirus b3 in balb/c mice was studied on 3rd--90th day after the inoculation. 99mtc-pyp uptake ratio, measured by the ratio of cpm/gm for the heart to cpm/gm for the skull, began to increase five days after virus inoculation and reached a maximum on the seventh day. after the 14th day, 99mtc-pyp ratio began to decrease, however, on the 90th day, a high 99mtc-pyp uptake was shown in mice with se ... | 1980 | 6253697 |
| experimental coxsackievirus b3 perimyocarditis in the right ventricle in balb/c mice: a one-year follow-up study. | we described severe perimyocarditis in weanling balb/c mice inoculated with coxsackievirus b3 (nancy strain) which was exclusively limited to the right ventricle. yellowish-white patches were seen on the surface of the right ventricle of the heart on the seventh day through 360th day after inoculation with virus. following myocardial degeneration and necrosis, marked perimyocardial fibrosis with calcification was observed 90 days after inoculation with virus and persisted through 360th day. spon ... | 1980 | 6253698 |
| induction of diabetes by cumulative environmental insults from viruses and chemicals. | encephalomyocarditis virus (emc) induces diabetes in certain inbred strains of mice by infecting and destroying pancreatic beta cells, the severity of the diabetes depending on the number of beta cells destroyed. in strains of mice resistant to emc-induced diabetes, insufficient beta cells are damaged to alter glucose homeostasis. however, diabetes can be produced in many species by streptozotocin, a highly specific beta-cell toxin. here, we used concentrations of streptozotocin that did not pro ... | 1980 | 6253833 |
| [viral neuraxitis. further studies of the current epidemiological and clinical aspects]. | an epidemiological and clinical investigation upon ten cases of acute viral neuraxitis observed in the country of alessandria between january 1978 - january 1979, is reported. four cases of neuraxitis were due to coxsackie b4 virus, two to coxsackie b3, two to influenza type a and one to influenza type b virus, one to rubella and one to varicella-zooster virus. in all the cases blood chemistry, clinical and instrumental examinations (eegraphy, cerebral scintigraphy and angiography) were coupled ... | 1980 | 6253851 |
| [karyotype change in human cell cultures in the process of the reversion of coxsackie b virus sensitivity]. | the study was done on a subline of cells reverting to sensitivity to coxsackie b3 virus after treatment of j-41 cells resistant to this virus with a homogenate prepared from the sensitive j-96 cell culture. cytogenetic examinations of this cell subline showed its karyological characteristics to approach those of the sensitive j-96 culture. the modal number of chromosomes and the number of chromosomes 2, 9, 11, 12, and 21 were completely restored and marker chromosomes typical of the sensitive cu ... | 1980 | 6254264 |
| [virological analyses of irradiated sewer sludge (author's transl)]. | the virus-inactivating effect of co60 irradiation was verified by a field test in the sewer sludge irradiation plant at geiselbullach near munich. the following samples were tested: 16 waste water inlets 15 waste water outlets 32 fresh sludge samples 62 sewer sludge samples prior to irradiation 52 sewer sludge samples and 9 fresh sludge samples after irradiation. we supplemented these analyses by inoculating sewer sludge samples with polio inoculation virus type 1 before irradiation and by the a ... | 1980 | 6254288 |
| "coxsackie virus in diabetes mellitus". | 1980 | 6256289 | |
| [studies on the interference system between "cold" and "hot" mutants of coxsackie b 6 virus]. | 1980 | 6257991 | |
| survival of enteroviruses in rapid-infiltration basins during the land application of wastewater. | the downward migration through soil of seeded poliovirus type 1 and echovirus type 1 and of naturally occurring enteroviruses during infiltration of sewage effluent through rapid-infiltration basins was investigated. after 5 days of flooding, the amount of seeded poliovirus type 1 that had migrated 5 to 10 cm downward through the soil profile was found to be 11% of that remaining at the initial burial depth. the amount of echovirus type 1 determined to have moved an equal distance was at least 1 ... | 1980 | 6258471 |
| comparative inactivation of viruses by chlorine. | the kinetics of inactivation of six enteric viruses plus simian virus 40 and kilham rat virus by free available chlorine was studied under carefully controlled laboratory conditions. it was found that the different virus types demonstrated a wide range of susceptibility to chlorine disinfection. the rate of inactivation was greater at ph 6 than at ph 10; however, the relative susceptibilities of the different viruses were affected differently by a change in ph, suggesting that the ph influenced ... | 1980 | 6258473 |
| [recovery of the sensitivity of j-41 cells to coxsackie b3 virus by treatment with exogenous alkaline phosphatase]. | it has been shown that injection of g-41 cell cultures, deficient as regards alkaline phosphatase and resistant to coxsackie b3 virus, in conjunction with exposure to an alkaline phosphatase preparation from the calf intestine results in virus reproduction. depending on the dose administered and multiplicity of infection there occur either complete destruction of the monolayer or death of some cells with the development of cytopathic changes specific for coxackie virus. | 1980 | 6258669 |
| virological study of idiopathic cardiomyopathy: serological study of virus antibodies and immunofluorescent study of myocardial biopsies. | in 113 patients with idiopathic cardiomyopathy paired sera obtained 2--4 weeks apart were examined for neutralizing antibody to coxsackie b 1--6, and echo 4, 6, 7, 9 and 11 viruses. only eight cases (6.9 per cent) showed a significant change in titer, indicating a virus infection during or shortly before the study. complement-fixing antibody titers were measured in 126 patients and neutralizing antibodies in 116 patients with idiopathic cardiomyopathy. more patients had complement-fixing antibod ... | 1981 | 6259384 |
| [karyological characteristics of the transplantable human cell line j-96, susceptible to coxsackie b3 virus, and of its derived subline j-41, specifically resistant to this virus]. | the paper is concerned with comparative cytogenetic studies of human cell line j-96 and subline j-41 derived from it. application of g-, r- and c-techniques for differential staining of chromosomes made it possible to determine both numeric and structural changes in chromosomes of the resistant subline as compared to the initial one. the mechanisms contributing to a decrease in the normal chromosome number and to appearance of new marker chromosomes in the resistant subline cells are discussed a ... | 1981 | 6259787 |
| pancreatic uptake of 99tc stannous pyrophosphate in experimental viral pancreatitis in mice. | the pancreatic uptake of 99mtc stannous pyrophosphate (99mtc-pyp) in acute pancreatitis in mice induced by coxsackievirus b3 was studied. 99mtc-pyp uptake ratio, measured by the ratio of counts/min/g for the pancreas to counts/min/g for the skull, began to increase 2 days after virus inoculation and markedly increased on day 3 when necrosis of pancreatic acinar cells was evident. on day 5, 99mtc-pyp ratio reached a maximum (2.95 +/- 1.85, mean +/- sd) and histologically fine granules of calcific ... | 1981 | 6260500 |
| sex-related differences in the pattern of coxsackievirus b-3-induced immune spleen cell cytotoxicity against virus-infected myofibers. | spleen cells from adult balb/c mice injected intraperitoneally with purified coxsackievirus b-3 were tested for cytotoxicity against 51cr-labeled syngeneic infected and uninfected myofibers. both male and female immune cells were active against uninfected targets; this reactivity was evident by day 3 of infection and persisted throughout the first week. however, we observed marked sex-related differences in immune cell cytotoxicities against infected myofibers. males exhibited a strong t-lymphoc ... | 1981 | 6260687 |
| coxsackie b virus infections of the heart in adults-clinical aspects and long term follow up. | 1980 | 6260732 | |
| virus infection of endothelial cells. | endothelial injury is important in the pathogenesis of thrombosis, atherosclerosis, disseminated intravascular coagulation, and vasculitis. the ability of several common human viruses to infect cultures of endothelial cells obtained from human umbilical veins or bovine thoracic aorta was demonstrated. indicators of infection included cytopathology, viral growth curves, and antigen detection by immunofluorescence. herpes simplex virus type 1, adenovirus type 7, measles virus, and parainfluenza vi ... | 1981 | 6260874 |
| uptake and survival of enteric viruses in the blue crab, callinectes sapidus. | uptake of poliovirus 1 by the blue crab, callinectes sapidus, was measured to assess the likelihood of contamination by human enteric viruses. virus was found in all parts of the crab within 2 h after the crab was placed in contaminated artificial seawater. the highest concentrations of virus were found in the hemolymph and digestive tract, but the meat also contained virus. the concentration of virus in the crabs was generally less than in the surrounding water. changes in salinity did not subs ... | 1981 | 6261683 |
| inactivation of poliovirus and other enteroviruses by solutions of sodium fluoride at low ph. | solutions of sodium fluoride at ph 3 to 4 inactivated enteroviruses, whereas other sodium salts had little or no effect on virus infectivity. solutions of potassium fluoride also inactivated viruses under similar conditions. light, temperature, and the presence of organic compounds such as detergents and fecal matter did not affect inactivation of virus by 0.4 m solutions of sodium fluoride at ph 3. to 4. decreasing the sodium fluoride concentration below 0.04 m or raising the ph above 4 reduced ... | 1981 | 6261691 |
| infectivity titers of enterovirus as found in human stools. | data have been gathered and collated from a variety of sources both published and unpublished, dealing with the concentration of enteroviruses in human stools. for polioviruses, a general range of 3.0-6.5 log10 tcd50 per gram of stool was reported, whereas for coxsackieviruses and echoviruses the range has been from 2.0-5.5 log10 tcd50. as human stools average about 100 gm, it is not unusual for an infected person to excrete as much as 10-300 million tcd50 of virus daily. the results of enterovi ... | 1980 | 6262449 |
| enzyme-linked immunosorbent assay for the detection and identification of coxsackie b antigen in tissue cultures and clinical specimens. | an enzyme-linked immunosorbent assay (elisa) has been developed for the identification of coxsackie b antigens. this assay was capable of identifying and distinguishing all six coxsackie b serotypes at concentrations one hundredfold to ten thousandfold less than could be detected by complement fixation (cf) systems. in addition, the coxsackie b elisa correctly identified the presence of coxsackie b antigen in 19 of 21 tissue culture fluids and five of nine rectal swab specimens. two additional r ... | 1980 | 6262456 |
| survival of enteroviruses and coliform bacteria in a sludge lagoon. | enteroviruses associate with aerobically and anaerobically digested sludge were determined before the addition of the sludge to a sludge lagoon. the fate of sludge-associated viruses was followed during detention of sludge in the lagoon and after application of sludge to land for disposal. while digested sludge was being added to the lagoon, enteroviruses were readily detected in grab samples of sludge from the lagoon. sludge-associated viruses dropped to low or undetectable levels after disposa ... | 1981 | 6263184 |
| procedure for recovery of enteroviruses from the japanese cockle tapes japonica. | the most likely shellfish to be harvested if sportfishing is reinstated in san francisco bay is the japanese cockle tapes japonica. the virus levels present in these shellfish are unknown and need to be evaluated before the shellfish beds are open. towards this end, a procedure for recovering and concentrating enteric viruses from these clams has been evaluated. effective elution of poliovirus from clam tissues was found to occur with ph 9.5 glycine-buffered saline rather than with the ph 7.5 fl ... | 1981 | 6263186 |
| ultrastructural alterations of the myocardium in coxsackie b-3 virus myocarditis in mice. 18 months follow-up study by transmission and analytical electron microscopy. | 1981 | 6264176 | |
| experimental coxsackie b-3 virus myocarditis in golden hamsters. light and electron microscopy findings in a long-term follow-up study. | following intraperitoneal inoculation with coxsackie b3 virus all weaning syrian golden hamsters (60 animals) developed severe myocarditis. in the acute phase, light and electron microscopy revealed massive cellular infiltration and myocytolysis in the myocardium which were most prominent on the 5th day and least obvious in 3 weeks. in the necrotic myocytes, mitochondria contained moderately electron dense inclusions different from the calcified granules seen in the myocardium of mice with coxsa ... | 1981 | 6264177 |
| survival following myocarditis and myocardial calcification associated with infection by coxsackie virus b-4. | a coxsackie virus b-4 was isolated from a neonate with clinical sepsis and clinical evidence of myocardial dysfunction. radiographs demonstrated the presence and subsequent resolution of myocardial calcification. electrocardiograms showed a left bundle branch block, presumably caused by calcification in the corresponding segment of the bundle of his. this case demonstrates an unusual complication of neonatal coxsackie virus b infection. | 1981 | 6264379 |
| survival of polioviruses and echoviruses in acanthamoeba castellanii cultivated in vitro. | cultures of acanthamoeba castellanii, kept at room temperature in sterile bacto-casitone (difco) medium, were artificially infected with vaccination poliovirus strains type 1 and type 3 and with echovirus type 4 and echovirus type 30. no remarkable virus cumulation was observed on the surface or inside amoeba cells during the observation period of 21 days. amoeba-adsorbed viruses were impossible to remove by repeated washings. virus neutralization with specific antisera showed that enteroviruses ... | 1981 | 6265550 |
| the viral factor in the etiology of acute asthma attacks in children. | over the last decade firm proponents of a viral etiology have risen, alongside those considering mycoplasma as prime agent in the induction of bronchospasm. since we are not convinced as to the validity of the viral hypothesis, we decided to study a group of asthmatics to detect the different viral antigens serologically, in order to determine which can play a decisive role in the pathogenesis of the asthmatic crisis. without previous etiologic selection, 37 children admitted as emergency cases ... | 1981 | 6266242 |
| effect of soil permeability on virus removal through soil columns. | laboratory experiments were performed on four different soils, using 100 cm long columns, to determine the extent of virus movement when wastewater percolated through the soils at various hydraulic flow rates. unchlorinated secondary sewage effluent seeded with either poliovirus type 1 (strain lsc) or echovirus type 1 (isolate v239) was continuously applied to soil columns for 3 to 4 days at constant flow rates. water samples were extracted daily from ceramic samplers at various depths of the co ... | 1981 | 6266338 |
| experimental coxsackie b virus myocarditis in mice: 18 month histopathological and virological study. | in a series of experimental studies to test the hypothesis that idiopathic cardiomyopathy in man represents a sequela of virus myocarditis, coxsackie b 1, 3 or 5 virus was inoculated into icr mice with two different amounts, that is, a small amount (0.1 ml of 10(5.5) tcid50/ml) and a large amount (0.1 ml of 10(7.5) tcid50/ml). histopathological and immunofluorescent studies of the heart, analysis of the antibody titers in sera and evaluation of the virus concentration in various organs including ... | 1981 | 6267334 |
| [case of recurrent encephalomyeloradiculomeningitis after coxsackievirus infection]. | the authors report a case of recurring encephalomyeloradiculomeningitis after coxsackie b4 virus infection in a boy aged 14 years. the peculiar course of the disease is interpreted as an expression of the neuroallergic process caused by preceding viral infection. | 1981 | 6267497 |
| paralytic poliomyelitis: old dogmas and new perspectives. | no poliovirus vaccines can be expected to eliminate the paralytic poliomyelitis that is caused by nonpolio enteroviruses or the cases that have been and continue to be diagnosed erroneously as paralytic poliomyelitis. polioviruses have been recovered from the feces of patients with paralytic disease that is definitely not poliomyelitis, and very rare cases of so-called "vaccine-associated" paralytic disease cannot be regarded as having been caused by the vaccine virus when it is present in the f ... | 1981 | 6269169 |
| serum substitute in epithelial cell culture media: nonfat dry milk filtrate. | a number of milk types and milk fractions were investigated as possible substitutes for serum in cell culture media. a filtrate of reconstituted nonfat dry milk showed promise. culture fluids containing 5% of the nonfat dry milk filtrate were used to propagate primary and continuous cell cultures, and the cell growth from these cultures was compared with that of cells grown in a serum-containing medium. the nonfat dry milk filtrate-supplemented medium supported the growth of all epithelial cells ... | 1981 | 6269491 |
| comparison of proliferation and cytopathogenicity of swine vesicular virus and coxsackievirus b5. | sequential appearance of both swine vesicular disease virus and coxsackievirus b5 antigens in a pig kidney cell line was studied by immunofluorescence and electron microscopy. the replication cycle of each virus was approximately 3-4 h. viral antigens were demonstrable in the cytoplasm 2 h after inoculation. a compact mass of fluorescence was seen when cells showed cytopathogenic effect at 5.5 h. after 3 h, a few viral particles, seen by electron microscopy, were in the cytoplasm. morphological ... | 1981 | 6269809 |
| proteolytic cleavage of vp1 in 'a' particles of coxsackievirus b3 does not appear to mediate virus uncoating by hela cells. | 'a' particle of coxsackievirus b3 were generated from native virus by heating and purified by sucrose gradient centrifugation. these particles were found to be similar to 'a' particles formed by elution from cellular receptors of hela cells. electrophoretic analysis of [35s]methionine-labelled 'a' particles revealed that treatment of the particles with chymotrypsin resulted in the cleavage of vp1 and the formation of a cleavage product which migrated between vp2 and vp3. analysis of the protease ... | 1981 | 6270273 |
| [role of viruses in the etiology of endocrine diseases]. | 1981 | 6270646 | |
| investigations on the circulation of viruses occurring in the respiratory tract of apparently healthy schoolchildren aged 7 to 14 years. | a number of 92 viral agents could be isolated from 1,000 nasopharyngeal secretion samples collected from apparently healthy schoolchildren aged 7-14 years. the following viruses were identified, in decreasing order of frequency: 42 influenza a/ussr 90/77 (h1n1), 20 adeno-, 20 parainfluenza, 8 coxsackie b1 and 2 herpes virus strains. | 1981 | 6272482 |
| comparison of capsid polypeptides of group b coxsackie-viruses and polypeptide synthesis in infected cells. | capsid polypeptides of all six types (b1-6) of group b coxsackieviruses were compared by high-resolution gel electrophoresis, and synthesis of protein and rna in b4- or b5-infected hela cells was analyzed. four polypeptides, vp1-4, were detected in each type. another polypeptide, vp0, slightly larger than vp1, was also detected in trace amounts in some types. vp1-3 showed different but characteristic molecular weights (vp1, 34,500 to 37,000; vp2, 31,000 to 36,000; vp3, 26,000 to 32,500), and pre ... | 1981 | 6275818 |
| [case of viral myocarditis with exudative pericarditis caused by coxsackie b3 virus]. | 1981 | 6278395 | |
| [coxsackie b virus neuropapillitis (author's transl)]. | 1981 | 6278558 | |
| antiviral activity of antibiotic-producing marine bacteria. | the stability of poliovirus 1 in estuarine water and sediment was examined. the present data indicated that a 2 log reduction in virus titer at 15 degrees c occurred within 6-7 days in water samples taken from estuarine waters on both sides of the atlantic ocean. the antiviral effect decreased significantly when the seawater was subjected to autoclaving but not when it was filtered. that the antiviral activity activity of the seawater was related to the growth activities of microorganisms was co ... | 1982 | 6279263 |
| host factors in coxsackievirus b4-induced pancreopathy. | the diabetogenic potential of the human isolate, coxsackievirus b4 (cb4) (edwards) was studied in three inbred mice strains, swr/j, dba/2, and c57bl/6. the mice were infected with this agent and evaluated for mortality, pancreatic histopathology, and glucose tolerance. results showed that the mortality induced by cb4 in these inbred strains differed considerably. there was no evidence of a correlation between virus-induced mortality and virus-induced pancreopathy. although cb4 (edwards) was most ... | 1982 | 6279960 |
| [cathepsin d activity in cells differing in their sensitivity to the poliomyelitis virus]. | 1982 | 6280396 |