Publications

brain food for alzheimer-free ageing: focus on herbal medicines.	healthy brain aging and the problems of dementia and alzheimer's disease (ad) are a global concern. beyond 60 years of age, most, if not everyone, will experience a decline in cognitive skills, memory capacity and changes in brain structure. longevity eventually leads to an accumulation of amyloid plaques and/or tau tangles, including some vascular dementia damage. therefore, lifestyle choices are paramount to leading either a brain-derived or a brain-deprived life. the focus of this review is t ...	2015	26092628
curcumin: a natural product for diabetes and its complications.	curcumin is the yellow-colored bioactive constituent of the perennial plant, curcuma longa l., which possesses a wide range of physiological and pharmacological properties such as antioxidant, anti-inflammatory, anticancer, neuroprotective and anti-diabetic activities. anti-diabetic activity of curcumin may be due to its potent ability to suppress oxidative stress and inflammation. moreover, it shows a beneficial role on the diabetesinduced endothelial dysfunction and induces a down-regulation o ...	2015	26088351
[study on names of wenyujin rhizoma curcumae and rhizoma curcumae longae concisa and their origins].	to study the name of wenyujin rhizoma concisum and film turmeric by literature research methods provide the basis for correct application of cuba in modern clinical application. wenyujin rhizoma concisum and film turmeric often called each other mutual generation and used as the same kind of medicine in the ancient prescriptions books. they were often recorded and stated as the same species of curcumae longae rhizoma. wenyujin rhizoma concisum and curcumae longae rhizoma also often called each o ...	2015	26084188
white light emission from vegetable extracts.	a mixture of extracts from two common vegetables, red pomegranate and turmeric, when photoexcited at 380 nm, produced almost pure white light emission (wle) with commission internationale d'eclairage (cie) chromaticity index (0.35, 0.33) in acidic ethanol. it was also possible to obtain wle in polyvinyl alcohol film (0.32, 0.25), and in gelatin gel (0.26, 0.33) using the same extract mixture. the colour temperature of the wle was conveniently tunable by simply adjusting the concentrations of the ...	2015	26083264
herbal composition gambigyeongsinhwan (4) from curcuma longa, alnus japonica, and massa medicata fermentata inhibits lipid accumulation in 3t3-l1 cells and regulates obesity in otsuka long-evans tokushima fatty rats.	adipocyte lipid accumulation due to impaired fatty acid oxidation causes adipocyte hypertrophy and adipose tissue increment, leading to obesity. the aim of this study was to determine the antiobesity effects of the herbal composition gambigyeongsinhwan (4) (ggh(4)) composed of curcuma longa l. (zingiberaceae), alnus japonica (thunb.) steud. (betulaceae), and the fermented traditional korean medicine massa medicata fermentata.	2015	26068433
effects of curcuma extract and visible light on adults with plaque psoriasis.	we conducted a phase iv randomized, double-blind, placebo-controlled, pilot clinical trial to investigate the safety and efficacy of oral curcumin together with local phototherapy in patients with plaque psoriasis.	2015	26066761
synthesis, characterization and anti-cancer activity of pluronic f68-curcumin conjugate micelles.	curcumin (cur), a nontoxic polyphenol derived from the rhizome of turmeric (curcuma longa), has been recognized as an anti-cancer and chemo-preventative agent. however, its clinical application for cancer treatment has been greatly limited due to its poor water-solubility and low bioavailability. to tackle this problem, pluronic f68-cur (f68-cur) conjugate micelles, which are amphiphilic copolymers, were designed and synthesized in this study. these highly stable micelles with cur concentrated i ...	2016	26066393
the beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: a recent update.	the concept of using phytochemicals has ushered in a new revolution in pharmaceuticals. naturally occurring polyphenols (like curcumin, morin, resveratrol, etc.) have gained importance because of their minimal side effects, low cost and abundance. curcumin (diferuloylmethane) is a component of turmeric isolated from the rhizome of curcuma longa. research for more than two decades has revealed the pleiotropic nature of the biological effects of this molecule. more than 7000 published articles hav ...	2015	26066364
proteomic analysis of g2/m arrest triggered by natural borneol/curcumin in hepg2 cells, the importance of the reactive oxygen species-p53 pathway.	curcumin (cur), an active ingredient from the rhizome of the plant curcuma longa, has wide anticancer activities. however, due to its poor solubility and hence poor absorption, cur has limited clinical applications. it is therefore important to develop an effective method to improve its absorption. natural borneol (nb), a terpene and bicyclic organic compound, has been extensively used as a food additive, and our previous studies show that it can improve the uptake of cur in cancer cells. howeve ...	2015	26051007
microparticles containing curcumin solid dispersion: stability, bioavailability and anti-inflammatory activity.	this work aimed at improving the solubility of curcumin by the preparation of spray-dried ternary solid dispersions containing gelucire®50/13-aerosil® and quantifying the resulting in vivo oral bioavailability and anti-inflammatory activity. the solid dispersion containing 40% of curcumin was characterised by calorimetry, infrared spectroscopy and x-ray powder diffraction. the solubility and dissolution rate of curcumin in aqueous hcl or phosphate buffer improved up to 3600- and 7.3-fold, respec ...	2016	26040724
clinical development of curcumin in neurodegenerative disease.	curcumin, a polyphenolic antioxidant derived from the turmeric root has undergone extensive preclinical development, showing remarkable efficacy in wound repair, cancer and inflammatory disorders. this review addresses the rationale for its use in neurodegenerative disease, particularly alzheimer's disease. curcumin is a pleiotropic molecule, which not only directly binds to and limits aggregation of the β-sheet conformations of amyloid characteristic of many neurodegenerative diseases but also ...	2015	26035622
the effect of curcuma longa extracted (curcumin) on the quality of cryopreserved boar semen.	the aim of this study was to determine the optimal concentration of curcumin needed for cryopreservation of boar semen. semen samples (n = 9) were collected from nine duroc boars which having proven fertility were used for routine artificial insemination. semen samples were collected and divided into six groups (groups a-f) according to various concentrations of curcumin in freezing extender (i.e. 0, 0.125, 0.25, 0.50, 0.75 and 1.0 mmol/l, respectively). the semen was frozen by traditional liqui ...	2015	26032188
curcumin inhibits growth of prostate carcinoma via mir-208-mediated cdkn1a activation.	prostate cancer (pc) is a prevalent cancer in aged men. curcumin is an active ingredient that has been extracted from the rhizome of the plant curcuma longa. recently, a potential of curcumin against pc has been reported in pc, whereas the underlying molecular mechanisms are not completely understood. here, we studied the effects of low-dose curcumin on pc cell growth. curcumin (from 0.2 to 0.8 μmol/l) dose-dependently inhibited the proliferation of pc cells, without affecting cell apoptosis. fu ...	2015	26032092
absolute configurations and no inhibitory activities of terpenoids from curcuma longa.	curcuma longa l., belonging to the zingiberaceae family, is a perennial herb and has been used as a spice and a pigment in the food industry. in the ongoing search for inhibitory reagents of no production and survey of the chemical composition of natural vegetable foods, the chemical constituents of c. longa used as spice were investigated. this investigation resulted in the isolation of 2 new terpenoids and 14 known analogues. their structures were established on the basis of the extensive anal ...	2015	26027687
curcumin and cancer: barriers to obtaining a health claim.	curcumin is a highly pleiotropic molecule found in the rhizomes of curcuma longa (turmeric). it is responsible for the yellow color of turmeric and has been shown to inhibit the proliferation of cancer cells and to be of use in preventing or treating a number of diseases. curcumin has been shown to modulate multiple cell-signaling pathways simultaneously, thereby mitigating or preventing many different types of cancers, including multiple myeloma and colorectal, pancreatic, breast, prostate, lun ...	2015	26024538
interaction between the antioxidant activity of curcumin and cholinergic system on memory retention in adult male wistar rats.	the cholinergic system plays an important role in learning and memory. this study investigated the effects of curcumin (turmeric extract) and the cholinergic system and their interaction on memory retention of passive avoidance learning in adult male wistar rats.	2015	26019804
inhibition of imiquimod-induced psoriasis-like dermatitis in mice by herbal extracts from some indian medicinal plants.	psoriasis is a chronic autoimmune human skin disorder that is characterized by excessive proliferation of keratinocytes, scaly plaques, severe inflammation and erythema. the pathophysiology of psoriasis involves interplay between epidermal keratinocytes, t lymphocytes, leukocytes and vascular endothelium. increased leukocyte recruitment and elevated levels of cytokines, growth factors and genetic factors like interleukin (il)-1β, il-6, il-17, il-22, il-23, tumour necrosis factor (tnf)-α, interfe ...	2016	26016607
anti-inflammatory activity of polysaccharide fraction of curcuma longa extract (nr-inf-02).	the aim of the study was to investigate the safety and anti-inflammatory effects of polysaccharide fraction (f1) of curcuma longa extract (nr-inf-02) in classical rodent models of inflammation. f1 was evaluated for its acute oral toxicity and found to be safe upto 5000 mg/kg body weight in rats. the anti-inflammatory activity of f1 was evaluated in acute (carrageenan - induced paw edema; xylene - induced ear edema) and chronic (cotton pellet - induced granuloma) models of inflammation. the resul ...	2015	26013326
in vitro effect of some egyptian herbal extracts against blastocystis hominis.	blastocystis hominis is an enteric parasite that inhabits the gastrointestinal tract of humans and many animals. this emerging parasite has a worldwide distribution. it is often identified as the most common eukaryotic organism reported in human fecal samples that showed a dramatic increase in recent years. metronidazole is the main therapy for blastocystosis. however, frequent reports of treatment failure suggesting isolates resistance to metronidazole. this study determined the growth pattern ...	2015	26012223
curcumin, inflammation, and chronic diseases: how are they linked?	it is extensively verified that continued oxidative stress and oxidative damage may lead to chronic inflammation, which in turn can mediate most chronic diseases including cancer, diabetes, cardiovascular, neurological, inflammatory bowel disease and pulmonary diseases. curcumin, a yellow coloring agent extracted from turmeric, shows strong anti-oxidative and anti-inflammatory activities when used as a remedy for the prevention and treatment of chronic diseases. how oxidative stress activates in ...	2015	26007179
report-isolation identification and control of vancomycin resistant staphylococcus aureus.	vancomycin resistant staphylococcus aureus (vrsa) has been reported from many parts of the world including asian countries. hence, main objective of study was to evaluate the possible occurrence of vrsa in hospitals of lahore city and to ensure the effectiveness of various substitute therapeutic options. a total of 150 samples of pus/wounds were collected from three hospitals of the city and vrsa were isolated and confirmed through recommended method of clinical and laboratory standards institut ...	2015	26004734
curcumin inhibits phip induced cytotoxicity in breast epithelial cells through multiple molecular targets.	amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (phip), found in cooked meat, is a known food carcinogen that causes several types of cancer, including breast cancer, as phip metabolites produce dna adduct and dna strand breaks. curcumin, obtained from the rhizome of curcuma longa, has potent anticancer activity. to date, no study has examined the interaction of phip with curcumin in breast epithelial cells. the present study demonstrates the mechanisms by which curcumin inhibits phip-induced cyto ...	2015	26004342
antibiotic overuse and clostridium difficile infections: the indian paradox and the possible role of dietary practices.	antibiotic abuse is rampant in india, such that one may expect to see an increase of clostridium difficile infections (cdi). however, we found that the incidence of cdi in india (1.67%) is no different from that reported in usa (1.6%) using similar techniques of detection (polymerase chain reaction test). we offer a possible explanation for this paradox. it is likely that a diet rich in fiber, yogurt, and possibly turmeric may have a protective role in decreasing the incidence of cdis in india.	2015	26004192
structure determination of two new bisabolane-type sesquiterpenes from the rhizomes of curcuma longa by nmr spectroscopy.		2015	25998199
curcumin ameliorates skeletal muscle atrophy in type 1 diabetic mice by inhibiting protein ubiquitination.	what is the central question of this study? we sought to examine whether curcumin could ameliorate skeletal muscle atrophy in diabetic mice by inhibiting protein ubiquitination, inflammatory cytokines and oxidative stress. what is the main finding and its importance? we found that curcumin ameliorated skeletal muscle atrophy in streptozotocin-induced diabetic mice by inhibiting protein ubiquitination without affecting protein synthesis. this favourable effect of curcumin was possibly due to the ...	2015	25998196
colloidal submicron-particle curcumin exhibits high absorption efficiency-a double-blind, 3-way crossover study.	curcumin is a major constituent of the spice turmeric and has various biological activities, including anticancer, antioxidant, and anti-inflammatory properties, as well as alcohol detoxification. however, because of its poor absorption efficiency, it is difficult for orally administered curcumin to reach blood levels sufficient to exert its bioactivities. to overcome this problem, several curcumin preparations with a drug-delivery system (dds) have been developed to increase the bioavailability ...	2015	25994138
effect of curcumin on pro-angiogenic factors in the xenograft model of breast cancer.	the formation of a new blood vessel is stimulated by angiogenic factors. curcumin, which is the active ingredient of the spice plant curcuma longa l and is used as food and traditional medicine, has shown anticancer effects against different types of cancers. we evaluated the effects of curcumin on angiogenesis/pro-angiogenic factors in a mouse model of human breast cancer. cell viability was measured by the mtt assay after curcumin treatment in triple-negative breast cancer cells (mda-mb-231). ...	2015	25991545
efficacy of adsorbents (bentonite and diatomaceous earth) and turmeric (curcuma longa) in alleviating the toxic effects of aflatoxin in chicks.	a study was conducted to determine the efficacy of bentonite clay (bc), diatomaceous earth (de) and turmeric powder (tum) in alleviating the toxic effects of aflatoxin b1 (afb1). a total of 250 ross-308 d-old male broiler chicks were assigned to 10 dietary treatments (5 replicates of 5 chicks) from hatch to d 21. dietary treatments were: basal diet; basal diet plus afb1 (2 mg) or bc (0.75%), or de (0.75%), or tum (200 mg/kg curcuminoids) and different combinations of afb1, bc, de and tum. feed i ...	2015	25990012
intrathecal curcumin attenuates pain hypersensitivity and decreases spinal neuroinflammation in rat model of monoarthritis.	curcumin is a major component of turmeric and reportedly has anti-inflammatory and anti-oxidant effects. neuroinflammation has been recognized to play an important role in the pathogenesis of various diseases in the central nervous system. here we investigated the anti-nociceptive and anti-neuroinflammatory effect of curcumin on arthritic pain in rats. we found that repeated oral treatment with curcumin, either before or after complete freund's adjuvant (cfa) injection, dose-dependently attenuat ...	2015	25988362
dendrosomal curcumin suppresses metastatic breast cancer in mice by changing m1/m2 macrophage balance in the tumor microenvironment.	curcumin, a lipid-soluble compound extracted from the plant curcuma longa, has been found to exert immunomodulatory effects via macrophages. however, most studies focus on the low bioavailability issue of curcumin by nano and microparticles, and thus the role of macrophages in the anticancer mechanism of curcumin has received little attention so far. we have previously shown the potential biocompatibility, biodegradability and anti-cancer effects of dendrosomal curcumin (dnc). in this study, twe ...	2015	25987060
[solidification of volatile oil with graphene oxide].	to evaluate the properties of solidifying volatile oil with graphene oxide, clove oil and zedoary turmeric oil were solidified by graphene oxide. the amount of graphene oxide was optimized with the eugenol yield and curcumol yield as criteria. curing powder was characterized by differential scanning calorimetry (dsc) and scanning electron microscopy (sem). the effects of graphene oxide on dissolution in vitro and thermal stability of active components were studied. the optimum solidification rat ...	2015	25975033
zingiberaceae extracts for pain: a systematic review and meta-analysis.	members of the family zingiberaceae including turmeric, ginger, javanese ginger, and galangal have been used for centuries in traditional medicine. preclinical studies of zingiberaceae extracts have shown analgesic properties. this study aims to systematically review and meta-analyze whether extracts from zingiberaceae are clinically effective hypoalgesic agents.	2015	25972154
assessment of genetic diversity in indigenous turmeric (curcuma longa) germplasm from india using molecular markers.	curcuma longa l., commonly known as turmeric, is one of the economically and medicinally important plant species. it is predominantly cultivated in the tropical and sub tropical countries. india is the largest producer, and exporter of turmeric in the world, followed by china, indonesia, bangladesh and thailand. in the present study, directed amplification of minisatellite dna (damd) and inter simple sequence repeats (issr), methods were used to estimate the genetic variability in indigenous tur ...	2015	25964716
demethoxycurcumin-induced dna damage decreases dna repair-associated protein expression levels in nci-h460 human lung cancer cells.	demethoxycurcumin (dmc) is a key component of chinese medicine (turmeric) and has been proven effective in killing various cancer cells. its role in inducing cytotoxic effects in many cancer cells has been reported, but its role regarding dna damage on lung cancer cells has not been studied in detail. in the present study, we demonstrated dmc-induced dna damage and condensation in nci-h460 cells by using the comet assay and dapi staining examinations, respectively. western blotting indicated tha ...	2015	25964547
inhibition of pi3k signaling triggered apoptotic potential of curcumin which is hindered by bcl-2 through activation of autophagy in mcf-7 cells.	curcumin is a natural anti-cancer agent derived from turmeric (curcuma longa). curcumin triggers intrinsic apoptotic cell death by activating mitochondrial permeabilization due to the altered expression of pro- and anti-apoptotic bcl-2 family members. phosphoinositol-3-kinase (pi3k) and akt, key molecular players in the survival mechanism, have been shown to be associated with the bcl-2 signaling cascade; therefore, evaluating the therapeutic efficiency of drugs that target both survival and the ...	2015	25960232
co-analgesic therapy for arthroscopic supraspinatus tendon repair pain using a dietary supplement containing boswellia serrata and curcuma longa: a prospective randomized placebo-controlled study.	the cuff tendon that is most prone to full-thickness rotator cuff tears is the supraspinatus (ssp). arthroscopic ssp repair ensures good to satisfactory mid- to long-term clinical outcomes. however, the intense postoperative pain reduces rehabilitation compliance and is cause of patient dissatisfaction. many natural compounds act by inhibiting inflammatory pathways in a similar way to anti-inflammatory drugs	2015	25957549
pilot-scale subcritical solvent extraction of curcuminoids from curcuma long l.	curcuminoids consisted curcumin, demethoxycurcumin and bisdemethoxycurcumin, were extracted from turmeric using subcritical solvent by varying conditions of temperature (110-150 °c), time (1-10 min), pressure (5-100 atm), solid-to-solvent ratio, and mixing ratio of solvent. preliminary lab-scale experiments were conducted to determine the optimum extraction temperature and mixing ratio of water and ethanol for the pilot-scale extraction. the maximum yield of curcuminoids in the pilot-scale syste ...	2015	25952841
curcumin prevents perfluorooctane sulfonate-induced genotoxicity and oxidative dna damage in rat peripheral blood.	perfluorooctane sulfonate (pfos) is a man-made fluorosurfactant and global pollutant. pfos a persistent and bioaccumulative compound, and it is widely distributed in humans and wildlife. therefore, it was added to annex b of the stockholm convention on persistent organic pollutants in may 2009. curcumin is a natural polyphenolic compound abundant in the rhizome of the perennial herb turmeric. it is commonly used as a dietary spice and coloring agent in cooking and anecdotally as an herb in tradi ...	2016	25950456
evaluation of the protective effects of curcuminoid (curcumin and bisdemethoxycurcumin)-loaded liposomes against bone turnover in a cell-based model of osteoarthritis.	curcumin (cur) and bisdemethoxycurcumin (bdmc), extracted from curcuma longa, are poorly water-soluble polyphenol compounds that have shown anti-inflammatory potential for the treatment of osteoarthritis. to increase cellular uptake of cur and bdmc in bone tissue, soybean phosphatidylcholines were used for liposome formulation. in this study, curcuminoid (cur and bdmc)-loaded liposomes were characterized in terms of particle size, encapsulation efficiency, liposome stability, and cellular uptake ...	2015	25945040
therapeutic effect of supercritical co2 extracts of curcuma species with cancer drugs in rhabdomyosarcoma cell lines.	synergistic effect of supercritical co2 extracts of curcuma species with conventional chemotherapeutic drugs was investigated in human alveolar (sjrh30) and embryonal (rd) rhabdomyosarcoma cell lines. the curcuma amada (mango ginger) (ca) extract showed the highest levels of cytotoxicity with inhibitory concentration ic50 values of 7.133 µg/ml and 7.501 µg/ml for sjrh30 and rd cell lines, respectively, as compared with curcuma longa (turmeric) and curcuma xanthorrhiza (javanese turmeric) extract ...	2015	25939344
inhibitory activity of curcumin derivatives towards metal-free and metal-induced amyloid-β aggregation.	when alzheimer's disease (ad) progresses, several pathological features arise including accumulation of misfolded protein aggregates [e.g., amyloid-β (aβ) plaques], metal ion dyshomeostasis, and oxidative stress. these characteristics are recently suggested to be interconnected through a potential factor, metal-associated aβ (metal-aβ) species. the role of metal-aβ species in ad pathogenesis remains unclear, however. to elucidate the contribution of metal-aβ species to ad pathology, as well as t ...	2015	25938870
effect of chitosan on rhizome rot disease of turmeric caused by pythium aphanidermatum.	chitosan was evaluated for its potential to induce antifungal hydrolases in susceptible turmeric plant (curcuma longa l.). under field conditions, the application of chitosan (crab shell) to turmeric plants by foliar spray method induces defense enzymes such as chitinases and chitosanases. such an increase in enzyme activity was enhanced by spraying chitosan (0.1% w/v) on leaves of turmeric plants at regular intervals. gel electrophoresis revealed new chitinase and chitosanase isoforms in leaves ...	2014	25937988
turmeric use is associated with reduced goitrogenesis: thyroid disorder prevalence in pakistan (thypak) study.	south asian population has a particularly high prevalence of thyroid disorders mainly due to iodine deficiency and goitrogen use. there is no data available for prevalence of thyroid disorders in the general population living in nonmountainous regions of pakistan.	2017	25932388
curcumin specifically binds to the human calcium-calmodulin-dependent protein kinase iv: fluorescence and molecular dynamics simulation studies.	calcium-calmodulin-dependent protein kinase iv (camk4) plays significant role in the regulation of calcium-dependent gene expression, and thus, it is involved in varieties of cellular functions such as cell signaling and neuronal survival. on the other hand, curcumin, a naturally occurring yellow bioactive component of turmeric possesses wide spectrum of biological actions, and it is widely used to treat atherosclerosis, diabetes, cancer, and inflammation. it also acts as an antioxidant. here, w ...	2016	25929263
aromatic-turmerone induces neural stem cell proliferation in vitro and in vivo.	aromatic (ar-) turmerone is a major bioactive compound of the herb curcuma longa. it has been suggested that ar-turmerone inhibits microglia activation, a property that may be useful in treating neurodegenerative disease. furthermore, the effects of ar-turmerone on neural stem cells (nscs) remain to be investigated.	2014	25928248
a hot water extract of curcuma longa inhibits adhesion molecule protein expression and monocyte adhesion to tnf-α-stimulated human endothelial cells.	the recruitment of arterial leukocytes to endothelial cells is an important step in the progression of various inflammatory diseases. therefore, its modulation is thought to be a prospective target for the prevention or treatment of such diseases. adhesion molecules on endothelial cells are induced by proinflammatory cytokines, including tumor necrosis factor-α (tnf-α), and contribute to the recruitment of leukocytes. in the present study, we investigated the effect of hot water extract of curcu ...	2015	25921559
metabolomic characterization of a low phytic acid and high anti-oxidative cultivar of turmeric.	turmeric, the rhizome of curcuma longa, has a long history of use as a spice and also as a traditional medicine in many asian countries. to reveal unique morphological features of a newly registered curcuma cultivar, c. longa cv. okinawa ougon (ougon), non-targeted lc-ms and gc-ms analyses were conducted. the analysis revealed its distinctive chemical properties: lower amount of phytic acid and inorganic metals such as fe, mn, and al, as well as higher concentrations of reduced derivatives of cu ...	2015	25920276
cytotoxic active constituents of essential oils of curcuma longa and curcuma zanthorrhiza.	the polar and apolar fractions of curcuma longa and c. zanthorriza enriched by ar-turmerone, ar-curcumene and xanthorrizol were screened for cytotoxic activity against the hela cell line. actinomycin d and curcumin were used as reference samples, both known for their cytotoxic properties. amongst all fractions tested, the xanthorrizol fraction (cc50: 26.1 ± 1.9 μm) showed the strongest cytotoxic properties similar to those of curcumin (cc50: 8.1 ± 1.7 μm). further studies also revealed that the ...	2015	25920236
flavonoids from curcuma longa leaves and their nmr assignments.	chemical investigation of the n-buoh-soluble fraction of the etoh extract of the aerial part of curcuma longa led to the isolation of 11 flavonol glycosides and one dihydroflavonol glucoside (1) via chromatography over sephadex lh-20 and lobar rp-18 columns. although they are known, the 1h and 13c nmr data recorded in cd3od rather than the common dmso-d6 are doubly checked via extensive 2d nmr spectroscopic analyses, leading to some revisions of the reported data, especially for the glycon part.	2015	25920221
ethnoveterinary plants for the treatment of camels in shiwalik regions of kathua district of jammu & kashmir, india.	camel is an important mode of transportation in the hot and hilly tracts of shiwaliks of kathua districts. the camel owners of the region lack the modern veterinary facilities and therefore depend heavily upon local treatments for the animal. this ethnoveterinary knowledge of plants is acquired by them from their forefathers and generally moves from one generation to another orally. the oral mode of transferring this valuable knowledge is vulnerable to erosion with the passage of time and genera ...	2015	25917839
heterocyclic curcumin derivatives of pharmacological interest: recent progress.	curcumin, a natural yellow polyphenol, is isolated from the herb curcuma longa l. (turmeric), a member of the ginger family. it has been extensively studied due to their multiple pharmacological properties. nevertheless, curcumin has disadvantages such as poor water solubility, poor bioavailability and rapid metabolism, which has prompted the search for analogues that overcome these shortcomings while maintaining or improving their good pharmacological properties. among the main curcumin analogu ...	2015	25915614
past, present and perspectives of manipur traditional medicine: a major health care system available for rural population in the north-east india.	traditional health care practices are still being followed extensively in manipur, north-east india. this is the major or the only medical facility available in some rural areas of manipur. cross cultural ethno-pharmacological survey was conducted to document traditional health care practices by maiba-maibi (male-female traditional health care practitioners of manipur).	2015	25895884
egfr inhibition by curcumin in cancer cells: a dual mode of action.	epidermal growth factor receptor (egfr) is an important target of anticancer therapy. nowadays, the search for new molecules inhibiting this receptor is turning toward natural substances. one of the most promising natural compounds that have shown an anti-egfr activity is curcumin, a polyphenol found in turmeric. its effect on the receptor kinase activity and on the receptor autophosphorylation has been already described, but the mechanism of how curcumin interacts with egfr is not fully elucida ...	2015	25893361
acute and chronic toxicity, cytochrome p450 enzyme inhibition, and herg channel blockade studies with a polyherbal, ayurvedic formulation for inflammation.	ayurvedic plants are known for thousands of years to have anti-inflammatory and antiarthritic effect. we have recently shown that bv-9238, a proprietary formulation of withania somnifera, boswellia serrata, zingiber officinale, and curcuma longa, inhibits lps-induced tnf-alpha and nitric oxide production from mouse macrophage and reduces inflammation in different animal models. to evaluate the safety parameters of bv-9238, we conducted a cytotoxicity study in raw 264.7 cells (0.005-1 mg/ml) by m ...	2015	25893199
influence of particle size on the in vitro and in vivo anti-inflammatory and anti-allergic activities of a curcumin lipid nanoemulsion.	the polyphenolic compound, curcumin, is a natural yellow pigment component of turmeric. it exerts various biological effects, such as anti-inflammatory effects, and we have previously demonstrated that curcumin is a specific inhibitor of dna polymerase λ. curcumin is characterized by poor bioavailability as it is water-insoluble, is poorly absorbed and is systemically eliminated. in order to increase the bioavailability of curcumin, in this study, we produced a curcumin-loaded lipid nanoemulsion ...	2015	25891482
curcumin inhibits appoptosin-induced apoptosis via upregulating heme oxygenase-1 expression in sh-sy5y cells.	appoptosin (slc25a38) is a pro-apoptotic protein, which is upregulated in alzheimer's disease (ad) brains and plays an important role in promoting the pathological progress of ad. the aim of this study was to investigate the effects of curcumin from the rhizome of curcuma longa on appoptosin-induced apoptosis in sh-sy5y cells.	2015	25891083
anti-inflammatory effects of novel curcumin analogs in experimental acute lung injury.	acute lung injury (ali) and its most severe form acute respiratory distress syndrome (ards) have been the leading cause of morbidity and mortality in intensive care units (icu). currently, there is no effective pharmacological treatment for acute lung injury. curcumin, extracted from turmeric, exhibits broad anti-inflammatory properties through down-regulating inflammatory cytokines. however, the instability of curcumin limits its clinical application.	2015	25889862
efficacy of turmeric as adjuvant therapy in type 2 diabetic patients.	it is known that there is a significant interplay of insulin resistance, oxidative stress, dyslipidemia, and inflammation in type 2 diabetes mellitus (t2dm). the study was undertaken to investigate the effect of turmeric as an adjuvant to anti-diabetic therapy. sixty diabetic subjects on metformin therapy were recruited and randomized into two groups (30 each). group i received standard metformin treatment while group ii was on standard metformin therapy with turmeric (2 g) supplements for 4 wee ...	2015	25883426
dissecting the role of curcumin in tumour growth and angiogenesis in mouse model of human breast cancer.	breast cancer is considered the most common cancer for women worldwide and it is now the second leading cause of cancer-related deaths among females in the world. since breast cancer is highly resistant to chemotherapy, alternative anticancer strategies have been developed. in particular, many studies have demonstrated that curcumin, a derivative of turmeric, can be used as natural agent in treatment of some types of cancer by playing antiproliferative and antioxidant effects. in our study, we a ...	2015	25879038
clinical evaluation of the role of tulsi and turmeric in the management of oral submucous fibrosis: a pilot, prospective observational study.	the aim of the present study was to investigate the clinical efficacy of herbal medicines (1 gm tulsi and 1 gm turmeric mixed in glycerine base) for the treatment of oral submucous fibrosis (osmf). forty-one patients in the age group of 17- 56 years without any systemic complications were included in the study. the patients were treated with medicines, which were to be applied 3-4 times a day. blood samples were collected before and after treatment to screen for any systemic changes due to these ...	2017	25878464
exploring the role of curcumin containing ethanolic extract obtained from curcuma longa (rhizomes) against retardation of wound healing process by aspirin.	the aim of the study was to assess the curcumin containing ethanolic extract (etoh) obtained from curcuma longa (cl) against retardation of wound healing by aspirin.	2017	25878374
combining curcumin (c3-complex, sabinsa) with standard care folfox chemotherapy in patients with inoperable colorectal cancer (cufox): study protocol for a randomised control trial.	the need for low toxicity adjuncts to standard care chemotherapy in inoperable colorectal cancer, with potential to improve outcomes and decrease the side-effect burden, is well recognised. addition of the low toxicity diet-derived agent, curcumin (the active ingredient of turmeric), to standard oxaliplatin-based therapy has shown promise in numerous pre-clinical studies.	2015	25872567
development and validation of a triplex real-time pcr assay for the simultaneous detection of three mustard species and three celery varieties in food.	the paper presents a triplex real-time pcr assay allowing the simultaneous detection of three mustard species (white, black and brown mustard) and three celery varieties (celery roots, celery stalks and leaf celery) in foodstuffs. the triplex assay does not show cross-reactivity with other brassicaceae. low cross-reactivities were observed with fenugreek, cumin, ginger, caraway, turmeric, lovage and rye, the δct values were, however, ⩾ 12 compared to positive controls. the triplex assay allows t ...	2015	25872425
combination of spices and herbal extract restores macrophage foam cell migration and abrogates the athero-inflammatory signalling cascade of atherogenesis.	the trapping of lipid-laden macrophages in the arterial intima is a critical but reversible step in atherogenesis. however, information about possible treatments for this condition is lacking. here, we hypothesized that combining the polyphenol-rich fractions (phc) of commonly consumed spices (allium sativum l (liliaceae), zingiber officinale r (zingiberaceae), curcuma longa l (zingiberaceae)) and herbs (terminalia arjuna (r) w & a (combretaceae) and cyperus rotundus l (cyperaceae)) prevents foa ...	2015	25869517
comparison of physicochemical properties of b-type nontraditional starches from different sources.	starches were isolated from rhizomes of curcuma longa, canna edulis and canna indica and bulbs of lilium lancifolium, and showed a b-type x-ray diffraction pattern. their physicochemical properties were investigated and compared. these starches showed significantly different granule morphologies and sizes, but all had eccentric hila. the c. longa starch had the lowest content of amylopectin short branch-chain and branching degree and the highest content of amylopectin long branch-chain, and the ...	2015	25869312
curcumin inhibits apoptosis and brain edema induced by hypoxia-hypercapnia brain damage in rat models.	curcumin, extracted from south asian spice turmeric, has been determined to have the promising ability in antioxidation and anti-inflammation. however, the effect of curcumin on treating brain damage has been not reported. in this article, the aim was to evaluate the effect of curcumin on cell apoptosis in rats exposed to hypoxia-hypercapnia and explore the therapeutic potential of curcumin in hypoxia-hypercapnia brain damage (hhbd). sprague dawley rats were randomly assigned into 3 groups: cont ...	2015	25867253
a novel, micro, rapid and direct assay to assess total antioxidant capacity of solid foods.	a novel, micro, rapid and direct procedure to measure the total antioxidant capacity of solid foods using 2, 2-diphenyl-1-picrylhydrazyl (dpph) (mr-quencher-dpph) was developed and validated. the mr-quencher-dpph assay was performed in semi-aqueous medium (methanol-tris buffer) using very small sample amounts (below 3.6 µg), as estimated by a bradford reagent-based chemical predictor, and it was completed in 10 min at room temperature. the total antioxidant capacity (tac) of solid foods was expr ...	2015	25863378
maintenance therapy containing metformin and/or zyflamend for advanced prostate cancer: a case series.	metformin is derived from galegine, a natural ingredient, and recent studies have suggested that metformin could enhance the antitumor effects of hormone ablative therapy or chemotherapy and reduce prostate cancer-specific mortality. zyflamend is a combination of herbal extracts that reduces inflammation and comprises turmeric, holy basil, green tea, oregano, ginger, rosemary, chinese goldthread, hu zhang, barberry, and basil skullcap. we propose a maintenance regimen with metformin and/or zyfla ...	2015	25861496
beyond yellow curry: assessing commercial curcumin absorption technologies.	few natural products have demonstrated the range of protective and therapeutic promise as have turmeric and its principal bioactive components: curcumin, demethoxycurcumin, and bisdemethoxycurcumin. success in translating this potential into tangible benefits has been limited by inherently poor intestinal absorption, rapid metabolism, and limited systemic bioavailability. seeking to overcome these limitations, food ingredient formulators have begun to employ a variety of approaches to enhance ab ...	2015	25856323
detection of plant-based adulterants in turmeric powder using dna barcoding.	in its powdered form, turmeric [curcuma longa l. (zingiberaceae)], a spice of medical importance, is often adulterated lowering its quality.	2015	25853978
molecular cloning and characterization of novel phytocystatin gene from turmeric, curcuma longa.	phytocystatin, a type of protease inhibitor (pi), plays major roles in plant defense mechanisms and has been reported to show antipathogenic properties and plant stress tolerance. recombinant plant pis are gaining popularity as potential candidates in engineering of crop protection and in synthesizing medicine. it is therefore crucial to identify pi from novel sources like curcuma longa as it is more effective in combating against pathogens due to its novelty. in this study, a novel cdna fragmen ...	2014	25853138
[study on absorbing volatile oil with mesoporous carbon].	clove oil and turmeric oil were absorbed by mesoporous carbon. the absorption ratio of mesoporous carbon to volatile oil was optimized with the eugenol yield and curcumol yield as criteria curing powder was characterized by scanning electron microscopy (sem) and differential scanning calorietry (dsc). the effects of mesoporous carbon on dissolution in vitro and thermal stability of active components were studied. they reached high adsorption rate when the absorption ratio of mesoporous carbon to ...	2014	25850263
clinical efficacy of the co-administration of turmeric and black seeds (kalongi) in metabolic syndrome - a double blind randomized controlled trial - tak-mets trial.	to compare the clinical efficacy of black seeds and turmeric alone and its co-administration in lower doses among patients with metabolic syndrome (mets).	2015	25847554
anti-inflammatory activity of polysaccharide fraction of curcuma longa (nr-inf-02).	the aim of the study was to investigate the safety and anti-inflammatory effects of polysaccharide fraction (f1) of curcuma longa (nr-inf-02) in classical rodent models of inflammation. f1 was evaluated for its acute oral toxicity and found to be safe upto 5000 mg/kg body weight in rats. the anti-inflammatory activity of f1 was evaluated in acute (carrageenan - induced paw edema; xylene - induced ear edema) and chronic (cotton pellet - induced granuloma) models of inflammation. the results of th ...	2015	25846947
high-performance thin-layer chromatography linked with (bio)assays and mass spectrometry - a suited method for discovery and quantification of bioactive components? exemplarily shown for turmeric and milk thistle extracts.	extraction parameters, chemical fingerprint, and the single compounds' activity levels were considered for the selection of active botanicals. for an initial survey, the total bioactivity (i.e., total reducing capacity, total flavonoids contents and free radical scavenging capacity) of 21 aqueous and 21 ethanolic plant extracts was investigated. ethanolic extracts showed a higher yield and were further analyzed by hptlc in detail to obtain fingerprints of single flavonoids and further bioactive ...	2015	25846263
novel curcumin-based pyrano[2,3-d]pyrimidine anti-oxidant inhibitors for α-amylase and α-glucosidase: implications for their pleiotropic effects against diabetes complications.	curcumin (bis-α,β-unsaturated β-diketone), the chief constituent of turmeric plant (curcuma longa), plays significant role in prevention of various diseases including diabetes. the research objective in the current study was to synthesize novel anti-diabetic curcumin derivatives with inhibitory properties against α-amylase (α-amy) and α-glucosidase (α-gls), as these two carbohydrate-hydrolysing enzymes are known to be important molecular targets for attenuation of postprandial hyperglycemia. the ...	2015	25843662
the influence of herbal medicine on platelet function and coagulation: a narrative review.	cardiovascular disease (cvd) is the leading cause of death worldwide. platelet activation and aggregation play a central role in hemostasis and thrombosis. herbal medicines have been traditionally used in the management of cvd and can play a role in modifying cvd progression, particularly in platelet function, and have the potential of altering platelet function tests, as well as some coagulation parameters. herbal medicines, such as feverfew, garlic, ginger, ginseng, motherwort, st john's wort, ...	2015	25839871
determination of curcuminoids in curcuma longa linn. by uplc/q-tof-ms: an application in turmeric cultivation.	cucuma longa linn. (fam-zingiberaceae) is a valued medicinal plant contains curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) as major bioactive constituents. previously reported analytical methods for analysis of curcuminoids were found to suffer from low resolution, lower sensitivity and longer analytical times. in this study, a rapid, sensitive, selective high-throughput ultra high performance liquid chromatography-tandem mass spectrometry (uplc/q-tof-ms) method was develope ...	2015	25838167
isolation and screening of endophytes from the rhizomes of some zingiberaceae plants for l-asparaginase production.	endophytes are described as microorganisms that colonize the internal tissues of healthy plants without causing any disease. endophytes isolated from medicinal plants have been attracting considerable attention due to their high biodiversity and their predicted potential to produce a plethora of novel compounds. in this study, an attempt was made to isolate endophytes from rhizomes of five medicinal plants of zingiberaceae family, and to screen the endophytes for l-asparaginase activity. in tota ...	2016	25830659
in vitro growth of curcuma longa l. in response to five mineral elements and plant density in fed-batch culture systems.	plant density was varied with p, ca, mg, and kno3 in a multifactor experiment to improve curcuma longa l. micropropagation, biomass and microrhizome development in fed-batch liquid culture. the experiment had two paired d-optimal designs, testing sucrose fed-batch and nutrient sucrose fed-batch techniques. when sucrose became depleted, volume was restored to 5% m/v sucrose in 200 ml of modified liquid ms medium by adding sucrose solutions. similarly, nutrient sucrose fed-batch was restored to se ...	2015	25830292
antimicrobial activity of turmeric extract and its potential use in food industry.	the present study investigates the antimicrobial and preservative potentials of turmeric extracts for food industry. turmeric extracts prepared in n-hexane, water, chloroform and ethanol were applied to meals as preservatives and antibacterial agent. the samples were assessed microbiologically (total bacterial, total fungal and total coliform counts) and organoleptically (color, odor, taste) at day zero and after 15 days intervals. meals autoclaved for shorter time (5 min) and treated with combi ...	2013	25829609
polyphenolic composition and antioxidant activities of 6 new turmeric (curcuma longa l.) accessions.	the phytochemical composition and antioxidant capacities of 6 new nrcri turmeric (curcuma longa l.) accessions (39, 35, 60, 30, 50 and 41) were determined using standard techniques. the moisture contents of the tumeric samples ranged from 15.75 to 47.80% and the curcumin contents of the turmeric samples fell within the range of curcumin obtained from turmeric in other countries of the world. furthermore, the turmeric accessions contained considerable amounts of antioxidants (measured using 2,2-d ...	2015	25827393
attenuation of morphine withdrawal syndrome by various dosages of curcumin in comparison with clonidine in mouse: possible mechanism.	herbal medical compounds and their major constituent have been used in the management and treatment of opioid withdrawal syndrome and pain. this study was carried out to clarify the effect of curcumin, the major compound of turmeric, on morphine withdrawal syndrome in mouse model and its possible mechanisms of pain relieving activity by assessing in writhing test as a model of visceral pain.	2015	25821292
curcumin inhibits aβ-induced microglial inflammatory responses in vitro: involvement of erk1/2 and p38 signaling pathways.	amyloid β (aβ) plays an important role in alzheimer's disease (ad) by inducing microglia activation. once activated, microglial cells promote the release of reactive species and cytokines that are known to enhance immune responses in ad brain. thus, negative regulators of microglia activation are considered as potential therapeutic candidates for ad. curcumin, the major yellow pigment in turmeric (curcuma longa), is proposed for its anti-inflammatory properties. several studies have indicated th ...	2015	25818332
synergistic mosquito-repellent activity of curcuma longa, pogostemon heyneanus and zanthoxylum limonella essential oils.	mosquito repellents play an important role in preventing man-mosquito contact. in the present study, we evaluated the synergistic mosquito-repellent activity of curcuma longa, pogostemon heyneanus and zanthoxylum limonella essential oils. the mosquito repellent efficacies of three essential oils were evaluated separately and in combination under laboratory and field conditions. n,n-diethylphenylacetamide (depa) and dimethylphthalate (dmp) were used for comparison of the protection time of the mi ...	2016	25817806
degradation of curcumin: from mechanism to biological implications.	curcumin is the main bioactive ingredient in turmeric extract and widely consumed as part of the spice mix curry or as a dietary supplement. turmeric has a long history of therapeutic application in traditional asian medicine. biomedical studies conducted in the past two decades have identified a large number of cellular targets and effects of curcumin. in vitro curcumin rapidly degrades in an autoxidative transformation to diverse chemical species, the formation of which has only recently been ...	2015	25817068
demethoxycurcumin induces the apoptosis of human lung cancer nci-h460 cells through the mitochondrial-dependent pathway.	lung cancer is the most common cause of cancer-related mortality in the us as well as other regions of the world. curcumin, demethoxycurcumin (dmc) and bisdemethoxycurcumin (bdmc) are the major components of curcuma longa l. it has been reported that curcumin inhibits the growth of various types of cancer cells in vitro and in vivo. however, the mechanisms involved in the inhibition of cell growth and induced apoptosis by dmc in human lung cancer cells remain unclear. in the present study, we in ...	2015	25813094
bactericidal activity of curcumin i is associated with damaging of bacterial membrane.	curcumin, an important constituent of turmeric, is known for various biological activities, primarily due to its antioxidant mechanism. the present study focused on the antibacterial activity of curcumin i, a significant component of commercial curcumin, against four genera of bacteria, including those that are gram-positive (staphylococcus aureus and enterococcus faecalis) and gram-negative (escherichia coli and pseudomonas aeruginosa). these represent prominent human pathogens, particularly in ...	2015	25811596
oxidative transformation of demethoxy- and bisdemethoxycurcumin: products, mechanism of formation, and poisoning of human topoisomerase iiα.	extracts from the rhizome of the turmeric plant are widely consumed as anti-inflammatory dietary supplements. turmeric extract contains the three curcuminoids, curcumin (≈80% relative abundance), demethoxycurcumin (dmc; ≈15%), and bisdemethoxycurcumin (bdmc; ≈5%). a distinct feature of pure curcumin is its instability at physiological ph, resulting in rapid autoxidation to a bicyclopentadione within 10-15 min. here, we describe oxidative transformation of turmeric extract, dmc, and bdmc and the ...	2015	25806475
[curcumin add-on therapy for ulcerative colitis].	ulcerative colitis (uc) is a chronic inflammatory disease of colon mucosa, which results from inappropriate inflammatory response. pharmacological treatments that are used to manage uc are usually targeted to moderate the inflammatory response, however, they are associated with significant adverse effects, which call for finding additional treatment options. curcumin is a polyphenol that is extracted from turmeric (curcuma longa). this medicinal plant has been traditionally used in india and in ...	2015	25796678
curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of er stress-associated txnip/nlrp3 inflammasome activation in a manner dependent on ampk.	curcumin is a natural polyphenolic compound in curcuma longa with beneficial effects on neuronal protection. this study aims to investigate the action of curcumin in the hippocampus subjected to glutamate neurotoxicity. glutamate stimulation induced reactive oxygen species (ros), endoplasmic reticulum stress (er stress) and txnip/nlrp3 inflammasome activation, leading to damage in the hippocampus. curcumin treatment in the hippocampus or sh-sy5y cells inhibited ire1α and perk phosphorylation wit ...	2015	25791922
a newly designed curcumin analog y20 mitigates cardiac injury via anti-inflammatory and anti-oxidant actions in obese rats.	obesity is strongly associated with the cause of structural and functional changes of the heart in both human and animal models. oxidative stress and inflammation play a critical role in the development of obesity-induced cardiac disorders. curcumin is a natural product from curcuma longa with multiple bioactivities. in our previous study, in order to reach better anti-inflammatory and anti-oxidant dual activities, we designed a new mono-carbonyl curcumin analog, y20, via the structural modifica ...	2015	25786209
¹h-nmr and ms based metabolomics study of the intervention effect of curcumin on hyperlipidemia mice induced by high-fat diet.	curcumin, a principle bioactive component of curcuma longa l, is well known for its anti-hyperlipidemia effect. however, no holistic metabolic information of curcumin on hyperlipidemia models has been revealed, which may provide us an insight into the underlying mechanism. in the present work, nmr and ms based metabolomics was conducted to investigate the intervention effect of curcumin on hyperlipidemia mice induced by high-fat diet (hfd) feeding for 12 weeks. the hfd induced animals were orall ...	2015	25786031
protection of turmeric plants from rhizome rot disease under field conditions by β-d-glucan nanoparticle.	the rhizome rot caused by pythium aphanidermatum is one of the most devastating diseases of the turmeric crop. fungicides are unable to control the rapidly evolving p. aphanidermatum and new control strategies are urgently needed. this study examined the effect of β-d-glucan nanoparticles (gnp) in turmeric plants under field condition by the foliar spray method. enhanced plant growth, rhizome yield, and curcumin content demonstrate the positive effect of the gnp on turmeric plants. rapid activat ...	2015	25783015
curcumin binding to beta amyloid: a computational study.	curcumin, a chemical constituent present in the spice turmeric, is known to prevent the aggregation of amyloid peptide implicated in the pathophysiology of alzheimer's disease. while curcumin is known to bind directly to various amyloid aggregates, no systematic investigations have been carried out to understand its ability to bind to the amyloid aggregates including oligomers and fibrils. in this study, we constructed computational models of (i) aβ hexapeptide (16) klvffa(21) octamer steric-zip ...	2015	25776887
liquid-liquid extraction and liquid chromatography-mass spectrometry detection of curcuminoids from bacterial culture medium.	liquid chromatography-mass spectrometry (lc-ms) has been used to detect polyphenolic curcuminoids found in turmeric but studies of metabolism by bacterial and mammalian cells in vitro are compromised by poor recovery from the culture medium. we report a liquid-liquid extraction procedure with ethyl acetate and use lc-ms to quantify extracted curcuminoids. ethyl acetate allows recoveries of ∼ 80-86% of curcuminoids from the bacterial growth medium, bacterial cell lysate and combined bacterial cel ...	2015	25770788
induction of bcl2-interacting killer, bik, is mediated for anti-cancer activity of curcumin in human head and neck squamous cell carcinoma cells.	naturally occurring diarylheptanoid curcumin (cur), a principal component of the asian spice turmeric, has been shown to have anti-cancer effects in many tumor types. however, a detailed mechanism regarding cur induced tumor cell killing remain to be comprehensively explored. using two head neck squamous cell carcinoma (hnscc) cell lines fadu (hypopharyngeal) and cal27 (tongue), we demonstrated a novel mechanism by which cur levies the cytotoxic effect. we found that cur induced upregulation of ...	2015	25767602
[recent advances in curcumin and its derivatives for treatment of liver diseases].	curcumin is a principal polyphenolic curcuminoid extracted from turmeric rhizome, which has been used for treating inflammation of joints, ulcers, jaundice and other disorders in asian traditional medicine. in recent years, many studies have indicated that curcumin plays important roles in treatment of liver diseases. curcumin attenuates liver injury and non-alcoholic fatty liver disease by lowering the release of inflammation cytokines, minimizing oxidative stress, enhancing the sensitivity of ...	2014	25757271
[breeding of new curcuma wenyujin variety "wenyujin no. 1"].	in order to breed and spread a new cultivar of curcuma wenyujin, the c. wenyujin germplasm resources were investigated in authentic regions. better varieties were chosen by comparing the yield, economic characters and quality differences between different cultivars. the results showed that the character of new selected cultivar was stable, the yield of zedoary, turmeric and curcuma was reached 313.7, 177.9, 91.2 kg per 667 m2, respectively, it increased 11.6%, 10.2%, 14.2% comparing with farmer ...	2014	25751938
postharvest processing and benefits of black pepper, coriander, cinnamon, fenugreek, and turmeric spices.	spices are prime source for flavor, aroma, and taste in cuisines and play an active role as medicines due to their high antioxidant properties. as medicine or food, the importance of spices cannot be overemphasized. the medicinal values of spices are very well established in treating various ailments like cancer, fever, malaria, stomach offset, nausea, and many more. a spice may be available in several forms: fresh, whole dried, or pre-ground dried which requires further processing to be utilize ...	2016	25747463