Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| curcumin and its analogues as potent inhibitors of low density lipoprotein oxidation: h-atom abstraction from the phenolic groups and possible involvement of the 4-hydroxy-3-methoxyphenyl groups. | curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, 1) is a yellow ingredient isolated from turmeric (curcumin longa). it has been shown to exhibit a variety of biological activities including antioxidative activity. in order to find more active antioxidants with 1 as the lead compound we synthesized curcumin analogues, i.e., 1,7-bis(3,4-dihydroxyphenyl)-1,6-heptadiene-3,5-dione (2), 1-(3,4-dihydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione (3), 1-(4-hydro ... | 2006 | 16443168 |
| inhibition of telomerase activity and induction of apoptosis by curcumin in k-562 cells. | telomerase, a reverse transcriptase that maintains telomere length, is highly activated in tumor cells and practically absent in somatic cells and hence considered a potential marker for tumorigenesis. a connection between telomerase activity and resistance to apoptosis has been established. telomerase, therefore, has been proposed to represent a novel and potentially selective target for cancer therapy. several synthetic compounds have been developed in recent years with a view to inhibit telom ... | 2006 | 16445949 |
| the effects of cannabinoids on p-glycoprotein transport and expression in multidrug resistant cells. | cannabis is the most widely used illicit drug in the world. cannabinoids are used therapeutically by some patients as they have analgesic, anti-emetic and appetite stimulant properties which palliate adverse symptoms. use of these agents in an oncology setting raises the question of whether they act to modulate the effectiveness of concurrently administered anti-cancer drugs. the transporter, p-glycoprotein (p-gp) confers multiple drug resistance (mdr) by effluxing a diverse array of anti-cancer ... | 2006 | 16458258 |
| suppressive effects of jcicm-6, the extract of an anti-arthritic herbal formula, on the experimental inflammatory and nociceptive models in rodents. | jcicm-6, the extract of an anti-arthritic herbal formula composed of medicinal herbs of sinomenium acutum, aconitum carmichaeli debx., curcuma longa l., paeonia lactiflora pall., and paeonia suffruticosa andr., was examined in the effectiveness and mechanism in reducing experimentally-induced inflammation and nociception using nine animal models. jcicm-6 was extracted from herbs and purified with amberlite xad-7hp adsorbent resin and analyzed with hplc-fingerprint for quality consistency. in acu ... | 2006 | 16462027 |
| ethnobotany of medicinal plants used by assamese people for various skin ailments and cosmetics. | the present paper deals with the medicinal plants used by the people of assam for curing different skin ailments and for cosmetics. a total of 85 plants belonging to 49 families have been documented for their therapeutic use against skin diseases and as herbal care. the herbal medicines were prepared from various plant parts of single plant, or multiple plants. the majority of the preparation was made using water as the medium. the mode of application was topical, but in many cases it was also a ... | 2006 | 16473486 |
| curcumin inhibits the proliferation and mineralization of cultured osteoblasts. | the effects of curcumin, which is an important constituent of rhizomes of the plant curcuma longa linn, on the metabolism of osteoblasts were examined in cultures of rat calvarial osteoblastic cells (rob cells). the proliferation of cells was markedly inhibited upon exposure of cells to curcumin at 5x10(-6) to 1x10(-5) m. curcumin at 1x10(-5) m did not induce apoptosis in rob cells but arrested cells at the g1 phase of the cell cycle. in addition, curcumin stimulated the expression of mrna for p ... | 2006 | 16476424 |
| study of the preparation of sustained-release microspheres containing zedoary turmeric oil by the emulsion-solvent-diffusion method and evaluation of the self-emulsification and bioavailability of the oil. | the purpose of this study was to design a sustained-release formulation of an oily drug. the sustained-release microspheres with self-emulsifying capability containing zedoary turmeric oil (zto) were prepared by the quasi-emulsion-solvent-diffusion method. the micromeritic properties, the efficiency of emulsification and the drug-release behavior of the resultant microspheres were investigated. the bioavailability of the microspheres was compared with conventional zto self-emulsifying formulatio ... | 2006 | 16480856 |
| turmeric (curcumin): a widely used curry ingredient, can contribute to oxidative stress in asian patients with acute vitiligo. | 2013 | 16481714 | |
| targeting angiogenesis with integrative cancer therapies. | an integrative approach for managing a patient with cancer should target the multiple biochemical and physiological pathways that support tumor development while minimizing normal tissue toxicity. angiogenesis is a key process in the promotion of cancer. many natural health products that inhibit angiogenesis also manifest other anticancer activities. the authors will focus on natural health products (nhps) that have a high degree of antiangiogenic activity but also describe some of their many ot ... | 2006 | 16484711 |
| use of liquid chromatography-electrospray ionization tandem mass spectrometry to identify diarylheptanoids in turmeric (curcuma longa l.) rhizome. | lc-esi-ms/ms coupled to dad analysis was used as an on-line tool for identification of diarylheptanoids in fresh turmeric rhizome extracts. based on their mass spectra, from both negative and positive mode lc-esi-ms/ms analysis, and supported by their dad spectra, 19 diarylheptanoids were identified. among these 19 compounds, curcumin, demethoxycurcumin, and bisdemethoxycurcumin were identified by comparing their chromatographic and spectral data with those of authentic standard compounds. the o ... | 2006 | 16490201 |
| curcumin induces heme oxygenase-1 in hepatocytes and is protective in simulated cold preservation and warm reperfusion injury. | preconditioning treatments hold significant potential for improving outcomes in solid organ transplantation. protective phenotypes can be induced using certain drugs. curcumin is a biologically active component of turmeric and has been reported to induce stress proteins in certain cell lines, leading to cell protection. this study investigates in detail the effect of curcumin on the stress-response in human hepatocytes, in particular its effect on heme oxygenase 1 (ho-1) and its cytoprotective e ... | 2006 | 16495813 |
| overexpression of p65/rela potentiates curcumin-induced apoptosis in hct116 human colon cancer cells. | curcumin, the yellow pigment in the spice turmeric, has potent chemopreventive activities that involve diverse molecular pathways. it is widely believed that curcumin pro-apoptotic properties are mediated by downregulation of nf kappa b (nfkappab). the p65/rela subunit of nfkappab may influence cell death, in part by activation of nfkappab anti-apoptotic target genes including x-linked inhibitor of apoptosis (xiap), a20, bcl-xl and inhibition of sustained activation of c-jun n-terminal kinase (j ... | 2006 | 16497702 |
| curcumin mediates ceramide generation via the de novo pathway in colon cancer cells. | a wealth of evidence supports the notion that curcumin, a phytochemical present in turmeric, is a potent chemopreventive agent for colon cancer. its mechanism of action remains incompletely understood. here we report that curcumin's apoptosis-inducing effects in colon cancer cell lines are accompanied by robust ceramide generation. this occurs through de novo synthesis as the increase in ceramide could be attenuated by pre-incubation of the cells with myriocin, and no changes were observed in sp ... | 2006 | 16501251 |
| evidence that curcuma longa possesses an active hypolipidemic effects in rabbits. | 2006 | 16501692 | |
| distribution of metals in the edible plants grown at jajmau, kanpur (india) receiving treated tannery wastewater: relation with physico-chemical properties of the soil. | the implications of metal contamination of agricultural soils due to long term irrigation with treated industrial wastewater and their subsequent accumulation in the vegetables/crops growing on such soils has been assessed in an area of industrial complex, jajmau, kanpur (india). physico-chemical properties of the soil were also studied. the soil and vegetables/crops were sampled from an area of 2100 acre agricultural land and analyzed for physico-chemical properties and metal accumulation in di ... | 2006 | 16502026 |
| effect of curcuma longa and ocimum sanctum on myocardial apoptosis in experimentally induced myocardial ischemic-reperfusion injury. | in the present investigation, the effect of curcuma longa (cl) and ocimum sanctum (os) on myocardial apoptosis and cardiac function was studied in an ischemia and reperfusion (i-r) model of myocardial injury. | 2006 | 16504000 |
| the effect of methanolic extract of tamarindus indica linn. on the growth of clinical isolates of burkholderia pseudomallei. | burkholderia pseudomallei (pseudomonas pseudomallei) causes melioidosis, a life-threatening infection common among paddy cultivators in southeast asian countries. no plant materials have been investigated for its activity against b. pseudomallei. therefore, a preliminary study was carried out using disc diffusion and minimum inhibitory concentration (mic) methods to evaluate the anti-b. pseudomallei activity of five indian medicinal plants documented to have been used for several ailments in the ... | 2005 | 16518004 |
| [preventive role of curcumin in lung cancer]. | carcinogens from cigarette smoke form the link between nicotine addiction and lung cancer, which is the leading cause of cancer-related mortality in the world. one of the most frequently studied chemopreventive agents is a curcumin, a natural compound extracted from turmeric that inhibits cell proliferation and induces apoptosis in human leukaemia, prostate cancer, and non-small cell lung cancer. curcumin (diferuoylmethane) is a major yellow pigment in turmeric (curcuma longa) and is widely used ... | 2005 | 16521985 |
| antitumor action of curcumin in human papillomavirus associated cells involves downregulation of viral oncogenes, prevention of nfkb and ap-1 translocation, and modulation of apoptosis. | curcumin (diferuloyl methane), the major yellow pigment from the rhizomes of turmeric (curcuma longa linn), has anticancer properties. infection with high-risk human papillomaviruses (hpv) leads to development of cervical carcinoma, predominantly through the action of viral oncoproteins e6 and e7. the present study aims at analyzing the antitumor and antiviral properties of curcumin, on hpv associated cervical cancer cells. our findings indicate curcumin to be cytotoxic to cervical cancer cells ... | 2006 | 16526022 |
| curcumin analogs as potent aldose reductase inhibitors. | in the present study, curcuminoids isolated from curcuma longa were demonstrated to possess inhibitory activities on bovine lens aldose reductase. in order to find more potent aldose reductase inhibitor, curcumin analogs were synthesized and evaluated for their ability to inhibit bovine lens aldose reductase enzyme. the results indicated that the compounds with tetrahydroxyl groups, 2,6-bis(3,4-dihydroxybenzylidene)cyclohexanone (a(2)), 2,5-bis(3,4-dihydroxybenzylidene)cyclopentanone (b(2)), 1,5 ... | 2006 | 16528793 |
| effect of bitter gourd and spent turmeric on constituents of glycosaminoglycans in different tissues in streptozotocin induced diabetic rats. | diet is now one of the well established means in the management of diabetes. bitter gourd and spent turmeric at 10% level were tested for their efficacy on glycosaminoglycan metabolism in various tissues viz., liver, spleen, lungs, heart and testis in control, diabetic and treated rats. the glycosaminoglycans (gags) were isolated from defatted and dried tissues. the contents of sulfated gags decreased in all the tissues and the decrease was more prominent in heart and testis. in the isolated gag ... | 2006 | 16532259 |
| inhibitory effect of cinnamoyl compounds against human malignant cell line. | in the present study, anti-proliferative effects of dietary polyphenolic compounds have been observed and demonstrated the strong anticancer efficacy of curcumin (cmn), an active constituent of dietary spice (turmeric) using human leukemia cancer cell line. cmn inhibited the proliferation of k562 leukemic cells by induction of apoptosis. the current study demonstrated synergy with combination of drug therapy, and suggested that combination of ferulic acid and cisplatin synergistically inhibited ... | 2006 | 16538860 |
| dose escalation of a curcuminoid formulation. | curcumin is the major yellow pigment extracted from turmeric, a commonly-used spice in india and southeast asia that has broad anticarcinogenic and cancer chemopreventive potential. however, few systematic studies of curcumin's pharmacology and toxicology in humans have been performed. | 2006 | 16545122 |
| curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells. | curcumin (diferuloylmethane), a polyphenol natural product of the plant curcuma longa, is undergoing early clinical trials as a novel anticancer agent. however, the anticancer mechanism of curcumin remains to be elucidated. here we show that curcumin inhibited growth of rhabdomyosarcoma cells (rh1 and rh30) (ic50 = 2-5 microm) and arrested cells in g1 phase of the cell cycle. curcumin also induced apoptosis and inhibited the basal or type i insulin-like growth factor-induced motility of the cell ... | 2006 | 16550606 |
| turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis. | turmeric has been used for centuries in ayurvedic medicine as a treatment for inflammatory disorders including arthritis. on the basis of this traditional usage, dietary supplements containing turmeric rhizome and turmeric extracts are also being used in the western world for arthritis treatment and prevention. however, to our knowledge, no data are available regarding antiarthritic efficacy of complex turmeric extracts similar in composition to those available for use as dietary supplements. th ... | 2006 | 16562833 |
| molecular targets of dietary agents for prevention and therapy of cancer. | while fruits and vegetables are recommended for prevention of cancer and other diseases, their active ingredients (at the molecular level) and their mechanisms of action less well understood. extensive research during the last half century has identified various molecular targets that can potentially be used not only for the prevention of cancer but also for treatment. however, lack of success with targeted monotherapy resulting from bypass mechanisms has forced researchers to employ either comb ... | 2006 | 16563357 |
| induction of g2/m arrest and inhibition of cyclooxygenase-2 activity by curcumin in human bladder cancer t24 cells. | curcumin, a polyphenol compound derived from curcuma longa linn, has been recognized as a promising anti-cancer drug due to its multiple properties including anti-inflammatory, anti-oxidant and anti-carcinogenic activities. to elucidate the mechanisms by which curcumin inhibits human bladder carcinoma t24 cell proliferation, we tested the effects of curcumin on specific cell cycle pathways and on the expression of cyclooxygenases (coxs). curcumin inhibited the growth of t24 cells and induced g2/ ... | 2006 | 16596191 |
| microemulsion electrokinetic chromatography for separation and analysis of curcuminoids in turmeric samples. | microemulsion ekc (meekc) was developed for quantitative analysis of curcuminoids, such as curcumin (c), demethoxycurcumin (d), and bis-demethoxycurcumin (b). meekc separation of curcuminoids was optimized, and a change in resolution was explained using a modified equation for resolution in meekc without electroosmosis. the suitable meekc conditions for separation of curcuminoids were obtained to be the microemulsion buffer containing 50 mm phosphate buffer at ph 2.5, 1.1% v/v n-octane as oil dr ... | 2006 | 16605086 |
| curcumin inhibits cell migration of human colon cancer colo 205 cells through the inhibition of nuclear factor kappa b /p65 and down-regulates cyclooxygenase-2 and matrix metalloproteinase-2 expressions. | curcumin (diferuloylmethane) is a chemical derived from several curcuma species (turmeric), possessing anti-inflammatory and antioxidant properties and which, thus, may be a potential anticancer drug. however, its mechanism of action is not fully understood. our previous studies had shown that curcumin induced cytotoxicity, cell cycle arrest and apoptosis in human colon cancer colo 205 cells. in this study, curcumin affected the levels of nf-kappab/ p65 in a time-dependent manner but did not aff ... | 2006 | 16619535 |
| dosage effects of curcumin on cell death types in a human osteoblast cell line. | curcumin, the yellow pigment of curcuma longa, is known to have antioxidant and anti-inflammatory properties, as well as their ability to either induce or prevent cell apoptosis. however, the precise molecular mechanisms of these effects are unknown. here, we demonstrate that curcumin can induce apoptotic changes, including jnk activation, caspase-3 activation, and cleavage of parp and pak2, at treatment concentrations lower than 25 microm in human osteoblast cells. in contrast, treatment with 5 ... | 2006 | 16624471 |
| curcumin targets akt cell survival signaling pathway in htlv-i-infected t-cell lines. | the akt signaling pathway is important for survival and growth of cancer cells. in the present paper we show that the akt signaling pathway is constitutively activated in human t-cell leukemia virus type i (htlv-i)-infected t-cell lines and in primary adult t-cell leukemia (atl) cells. curcumin, a natural compound present in turmeric, has been studied vigorously as a potent chemopreventive agent for cancer therapy because of its inhibitory effect on proliferation and induction of apoptosis in se ... | 2006 | 16630125 |
| effects of oxygen and turmeric on the formation of oxidative aldehydes in fresh-pack dill pickles. | hexanal, pentanal, and heptanal were found to be normal components of commercially processed, fresh-pack dill pickles. hexanal and pentanal were present at concentrations severalfold higher than their odor detection thresholds. these aldehydes were also found in pickles that were packed in the laboratory under anaerobic conditions. injection of oxygen into pickles prepared in anaerobic conditions resulted in the production of increasing the amounts of hexanal, heptanal, and pentanal. hexanal, pe ... | 2006 | 16637703 |
| curcumin potently blocks kv1.4 potassium channels. | curcumin, a major constituent of the spice turmeric, is a nutriceutical compound reported to possess therapeutic properties against a variety of diseases ranging from cancer to cystic fibrosis. in whole-cell patch-clamp experiments on bovine adrenal zona fasciculata (azf) cells, curcumin reversibly inhibited the kv1.4k+ current with an ic50 of 4.4 microm and a hill coefficient of 2.32. inhibition by curcumin was significantly enhanced by repeated depolarization; however, this agent did not alter ... | 2006 | 16647042 |
| ethanolic extracts from curcuma longa attenuates behavioral, immune, and neuroendocrine alterations in a rat chronic mild stress model. | the ethanolic extracts from the rhizome of curcuma longa l. (turmeric), possesses a wide variety of biological activities related to the treatment and prevention of affective disorders. to study their antidepressant effects, the impacts of chronic mild stress (cms) and of the subsequent administration of ethanolic extracts of c. longa were investigated. male sprague-dawley rats subjected to the cms procedure demonstrated increased serum interleukin-6 and tumor necrosis factor-alpha levels, as we ... | 2006 | 16651723 |
| safety and efficacy of nt, an herbal supplement, in treating human obesity. | a human pilot study testing the safety and effectiveness of nt (number ten), a dietary herbal supplement made from rhubarb, ginger, astragulus, red sage and turmeric, to reduce food intake and cause weight loss. | 2006 | 16652135 |
| cytotoxic effect of curcumin on giardia lamblia trophozoites. | giardia lamblia is one of the most important worldwide causes of intestinal infections produced by protozoa. thus, the search for new alternative therapeutic approaches for this parasitic disease is very important. common drugs used to control and eradicate this infection, frequently exhibit side effects that force patients to abandon treatment. the present work evaluates the anti-protozoan activity of curcumin, the main constituent of turmeric. axenic g. lamblia (portland 1 strain) cultures wer ... | 2006 | 16678115 |
| inhibition of homodimerization of toll-like receptor 4 by curcumin. | toll-like receptors play a key role in sensing microbial components and inducing innate immune responses. ligand-induced dimerization of tlr4 is required for the activation of downstream signaling pathways. thus, the receptor dimerization may be one of the first lines of regulation in activating tlr-mediated signaling pathways and induction of subsequent immune responses. lps induces the activation of nf-kappab and irf3 through myd88- or trif-dependent pathways. curcumin, a polyphenol found in t ... | 2006 | 16678799 |
| developmental therapeutics: review of biologically based cam therapies for potential application in children with cancer: part i. | this article is a review of the status of biologically based complementary and alternative medicine (cam) therapies that have potential anticancer activity with a focus on those agents that may be active in childhood cancer. the review presented in 2 parts includes the descriptions of the mechanisms that underlie their effects, the manner by which these agents are identified and evaluated and discussion of some of the limitations of current research. the first part introduces the topic of biolog ... | 2006 | 16679919 |
| curcumin inhibits hypoxia-induced angiogenesis via down-regulation of hif-1. | hypoxia-inducible factor-1 (hif-1) has a central role in cellular responses to hypoxia, including the transcriptional activation of a number of genes involved in angiogenesis in tumors. we found that curcumin, a natural, biologically active compound isolated from the commonly used spice turmeric, significantly decreases hypoxia-induced hif-1alpha protein levels in hepg2 hepatocellular carcinoma cells. moreover, curcumin suppressed the transcriptional activity of hif-1 under hypoxia, leading to a ... | 2006 | 16685395 |
| curcumin combats against cigarette smoke and ethanol-induced lipid alterations in rat lung and liver. | human population, in spite of the medical and scientific achievements, still fall as a prey to the evils of habitual smoking and alcohol, thus necessitating safer counteracting measures. objective: to evaluate the effect of cotreatment of curcumin (curcuma longa) in rats subjected to acute exposure to cigarette smoke (cs) and ethanol (etoh). | 2006 | 16691314 |
| biological effects of curcumin and its role in cancer chemoprevention and therapy. | curcumin, a natural component of the rhizome of curcuma longa has emerged as one of the most powerful chemopreventive and anticancer agents. its biological effects range from antioxidant, anti-inflammatory to inhibition of angiogenesis and is also shown to possess specific antitumoral activity. the molecular mechanism of its varied cellular effects has been studied in some details and it has been shown to have multiple targets and interacting macromolecules within the cell. curcumin has been sho ... | 2006 | 16712454 |
| resistance to apoptosis of hcw-2 cells can be overcome by curcumin- or vincristine-induced mitotic catastrophe. | the term mitotic catastrophe has recently become widely used to describe a form of death affecting many cancer cells, which, because of severe dna or mitotic spindle damage, are not able to bypass mitosis. we show here that cells of the hl-60-derived hcw-2 line highly resistant to apoptosis, upon treatment with curcumin or vincristine, undergo mitotic catastrophe that is finalized by caspase 3 activation and oligonucleosomal dna degradation. curcumin is a natural dye, derived from curcuma longa ... | 2006 | 16721786 |
| scabies. | scabies is a neglected parasitic disease that is a major public health problem in many resource-poor regions. it causes substantial morbidity from secondary infections and post-infective complications such as acute post-streptococcal glomerulonephritis. disease control requires treatment of the affected individual and all people they have been in contact with, but is often hampered by inappropriate or delayed diagnosis, poor treatment compliance, and improper use of topical compounds such as per ... | 2006 | 16731272 |
| down-regulation of prostaglandin e2 by curcumin is correlated with inhibition of cell growth and induction of apoptosis in human colon carcinoma cell lines. | several in vitro and in vivo studies have demonstrated an association between curcumin, a diferuloylmethane derived from the plant curcuma longa, and colorectal cancer (crc) prevention. nevertheless, the molecular mechanism responsible for the chemopreventive effect of curcumin is not well understood and most probably involves several pathways. several studies indicate that curcumin may exert its effect by specifically inhibiting the cyclooxygenase-2 (cox-2) isoenzyme, which is up-regulated in 4 ... | 2006 | 16737669 |
| effect of curcumin on protein glycosylation, lipid peroxidation, and oxygen radical generation in human red blood cells exposed to high glucose levels. | curcumin (diferuloylmethane) is the most active component of turmeric. it is believed that curcumin is a potent antioxidant and anti-inflammatory agent. experimental studies with diabetic animals demonstrate that curcumin supplementation can suppress cataract development and collagen cross-linking, promote wound healing, and lower blood lipids and glucose levels. the mechanism by which curcumin may cause diabetes-associated vascular damage to regress is not known. erythrocytes were treated with ... | 2006 | 16781457 |
| comparison of anti-inflammatory activities of six curcuma rhizomes: a possible curcuminoid-independent pathway mediated by curcuma phaeocaulis extract. | we aimed to compare the anti-inflammatory activities of six species of curcuma drugs using adjuvant arthritis model mice. when orally administered 1 day before the injection of adjuvant, the methanol extract of curcuma phaeocaulis significantly inhibited paw swelling and the serum haptoglobin concentration in adjuvant arthritis mice. also when orally administered 1 day after the injection of adjuvant, the methanol extract of curcuma phaeocaulis significantly inhibited paw swelling. other curcuma ... | 2006 | 16786056 |
| antioxidant therapeutic targets in copd. | oxidative stress and chronic inflammation are important features in the pathogenesis of chronic obstructive pulmonary disease (copd). oxidative stress has important consequences for several elements of lung physiology and for the pathogenesis of copd, including oxidative inactivation of antiproteases and surfactants, mucus hypersecretion, membrane lipid peroxidation, alveolar epithelial injury, remodeling of extracellular matrix, and apoptosis. therefore, targeting oxidative stress with antioxid ... | 2006 | 16787173 |
| antimicrobial effect of spices and herbs on vibrio parahaemolyticus. | the antimicrobial effects of spices and herbs from 18 plant species were examined on a foodborne pathogen, vibrio parahaemolyticus, with the use of combinations of temperatures and nutrient levels. basil, clove, garlic, horseradish, marjoram, oregano, rosemary, and thyme exhibited antibacterial activities at incubation of 30 degrees c, while with the exception of horseradish, the same spices and additional 7 species exhibited the activities at 5 degrees c. the lowest mic (minimum inhibitory conc ... | 2006 | 16797760 |
| curcumin's biphasic hormetic response on proteasome activity and heat-shock protein synthesis in human keratinocytes. | curcumin (diferuloylmethane), is a component of the yellow powder prepared from the roots of curcuma longa (zingiberaceae), also known as tumeric or turmeric. it is widely cultivated and used as a food ingredient in tropical areas of asia and central america. treatment of mid-passage human epidermal keratinocytes with curcumin resulted in a biphasic hormetic dose-response with respect to proteasome activity. curcumin treatment (up to 1 microm for 24 h) increased chymotrypsin-like activity by 46% ... | 2006 | 16804017 |
| modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. | modulation of cytokine secretion may offer novel approaches in the treatment of a variety of diseases. one strategy in the modulation of cytokine expression may be through the use of herbal medicines. a class of herbal medicines, known as immunomodulators, alters the activity of immune function through the dynamic regulation of informational molecules such as cytokines. this may offer an explanation of the effects of herbs on the immune system and other tissues. for this informal review, the aut ... | 2006 | 16813462 |
| turmeric and curcumin modulate the conjugation of 1-naphthol in caco-2 cells. | turmeric, the powdered dry rhizome of the curcuma longa plant, and curcumin, the major anti-oxidant constituent of turmeric, have been shown to possess chemopreventive activity. to elucidate the possible interaction of turmeric and curcumin with conjugation reactions, which in many cases are involved in the activation of procarcinogens, we measured their effects in the conjugation of 1-naphthol in caco-2 cells, a human colon carcinoma cell line, within a 24 h period. turmeric exhibits inhibitory ... | 2006 | 16819192 |
| curcumin inhibits telomerase activity in human cancer cell lines. | curcumin, one of the major components of tumeric, the dried rhizome of curcuma longa l, has been shown to have anti-proliferating and anti-carcinogenic properties. in this study, we examined the effects of curcumin on cell growth and telomerase activity in human cancer cell lines bel7402, hl60 and sgc7901. curcumin (1-32 microm) showed anti-proliferating effects on these cell lines in a dose-dependent manner in vitro, and anti-tumor effects when curcumin (50-200 mg/kg) was orally administered to ... | 2006 | 16820928 |
| curry consumption and cognitive function in the elderly. | curcumin, from the curry spice turmeric, has been shown to possess potent antioxidant and antiinflammatory properties and to reduce beta-amyloid and plaque burden in experimental studies, but epidemiologic evidence is lacking. the authors investigated the association between usual curry consumption level and cognitive function in elderly asians. in a population-based cohort (n = 1,010) of nondemented elderly asian subjects aged 60-93 years in 2003, the authors compared mini-mental state examinat ... | 2006 | 16870699 |
| physical properties of a new denture lining material containing a fluoroalkyl methacrylate polymer. | a new fluoride-containing, methacrylate-based denture lining material has been introduced. because of the fluoride content, this material is expected to demonstrate low water sorption and solubility and high stain resistance, but these attributes remain untested. | 2006 | 16872931 |
| screening and analysis of bioactive compounds in traditional chinese medicines using cell extract and gas chromatography-mass spectrometry. | as the cost of drug development is always many times more than that of drug discovery, predictive methods aiding in the screening of bioavailable drug candidates are of profound significance. in this paper, a novel method for screening bioactive compounds from traditional chinese medicines (tcms) was developed by using living cell extract and gas chromatography (gc)-mass spectrometer (ms). the method was validated by using elemene emulsion injection (eei), a typical tcm with known active compoun ... | 2007 | 16876368 |
| biosynthesis of curcuminoids and gingerols in turmeric (curcuma longa) and ginger (zingiber officinale): identification of curcuminoid synthase and hydroxycinnamoyl-coa thioesterases. | members of the zingiberaceae such as turmeric (curcuma longa l.) and ginger (zingiber officinale rosc.) accumulate at high levels in their rhizomes important pharmacologically active metabolites that appear to be derived from the phenylpropanoid pathway. in ginger, these compounds are the gingerols; in turmeric these are the curcuminoids. despite their importance, little is known about the biosynthesis of these compounds. this investigation describes the identification of enzymes in the biosynth ... | 2006 | 16890967 |
| ethnoveterinary medicines used for horses in trinidad and in british columbia, canada. | this paper investigates the commonalities in ethnoveterinary medicine used for horses between trinidad (west indies) and british columbia (canada). these research areas are part of a common market in pharmaceuticals and are both involved in the north american racing circuit. there has been very little research conducted on medicinal plants used for horses although their use is widespread. the data on ethnoveterinary medicines used for horses was obtained through key informant interviews with hor ... | 2006 | 16893454 |
| effects of capsaicin, dihydrocapsaicin, and curcumin on copper-induced oxidation of human serum lipids. | the oxidation of low-density lipoprotein (ldl) is believed to be the initiating factor for the development and progression of atherosclerosis. the active ingredients of spices such as chili and turmeric (capsaicin and curcumin, respectively) have been shown to reduce the susceptibility of ldl to oxidation. one of the techniques used to study the oxidation of ldl is to isolate ldl and subject it to metal-induced (copper or iron) oxidation. however, whole serum may represent a closer situation to ... | 2006 | 16910741 |
| regulation of inflammation and redox signaling by dietary polyphenols. | reactive oxygen species (ros) play a key role in enhancing the inflammation through the activation of nf-kappab and ap-1 transcription factors, and nuclear histone acetylation and deacetylation in various inflammatory diseases. such undesired effects of oxidative stress have been found to be controlled by the antioxidant and/or anti-inflammatory effects of dietary polyphenols such as curcumin (diferuloylmethane, a principal component of turmeric) and resveratrol (a flavonoid found in red wine). ... | 2006 | 16920072 |
| modulation of the function of the multidrug resistance-linked atp-binding cassette transporter abcg2 by the cancer chemopreventive agent curcumin. | curcumin (curcumin i), demethoxycurcumin (curcumin ii), and bisdemethoxycurcumin (curcumin iii) are the major forms of curcuminoids found in the turmeric powder, which exhibit anticancer, antioxidant, and anti-inflammatory activities. in this study, we evaluated the ability of purified curcuminoids to modulate the function of either the wild-type 482r or the mutant 482t abcg2 transporter stably expressed in hek293 cells and drug-selected mcf-7 flv1000 and mcf-7 advp3000 cells. curcuminoids inhib ... | 2006 | 16928820 |
| quantitative determination of eight components in rhizome (jianghuang) and tuberous root (yujin) of curcuma longa using pressurized liquid extraction and gas chromatography-mass spectrometry. | curcuma longa (zingiberaceae) is a native plant of southern asia and is cultivated extensively throughout the warmer parts of the world. jianghuang and yujin are rhizome and tuberous root of c. longa, respectively, which were traditionally used as two chinese medicines. in this paper, pressurized liquid extraction (ple) and gas chromatography-mass spectrometry (gc-ms) were developed for quantitative determination/estimation of eight characteristic compounds including beta-caryophyllene, ar-curcu ... | 2007 | 16930909 |
| tpa-induced up-regulation of activator protein-1 can be inhibited or enhanced by analogs of the natural product curcumin. | the activator protein-1 (ap-1) family of transcription factors, including the most common member c-jun-c-fos, participates in regulation of expression of numerous genes involved in proliferation, apoptosis, and tumorigenesis in response to a wide array of stimuli including pro-inflammatory cytokines, growth factors, stress, and tumor promoters. a number of plant polyphenols including curcumin, a yellow compound in the spice turmeric, have been shown to inhibit the activation of ap-1. curcumin is ... | 2006 | 16934760 |
| preclinical assessment of curcumin as a potential therapy for b-cll. | curcumin, the principle component of the spice turmeric, has been used as an anti-inflammatory medication in india and china for centuries. recent studies, predominantly using actively dividing cell lines, have suggested that this compound could be used as a chemopreventative or therapeutic agent for epithelial tumors. as curcumin has been reported to inhibit the nik/ikk complex, an activity that would be expected to induce apoptosis in b cell malignancies, we sought to determine whether curcumi ... | 2007 | 16947318 |
| curcumin activated both receptor-mediated and mitochondria-mediated proteolytic pathways for apoptosis in human glioblastoma t98g cells. | the therapeutic effect of curcumin (ccm), a polyphenolic compound from the rhizome of curcuma longa, has not yet been examined in glioblastoma. we used human glioblastoma t98g cells to explore the efficacy of ccm for inducing apoptosis and identifying proteolytic mechanisms involved in this process. trypan blue dye exclusion test showed decrease in cell viability with increasing dose of ccm. wright staining and apoptag assay showed, respectively, morphological and biochemical features of apoptos ... | 2006 | 16949208 |
| telomerase targeted anticancer bioactive prodrug by antisense-based approach. | a deoxy 11-mer oligonucleotide 5'-gttagggttag-3', complementary to a repeat sequence of human telomerase rna template has been linked through phosphate and a c-2 linker to a bioactive tetraglycine conjugate of curcumin, a well-known antitumor herbal spice component of turmeric. this molecule has been transfected into kb and hela cell lines and found to affect cell growth in the former. this dna-curcumin-tetraglycine acts as a prodrug being targeted by antisense mechanism to telomerase. | 2007 | 16950563 |
| a two generation reproductive toxicity study with curcumin, turmeric yellow, in wistar rats. | the reproductive toxicity of curcumin, turmeric yellow, in wistar rats was studied in order to generate additional relevant toxicity information for the use of curcumin in humans by oral administration. the two generation reproduction study was designed and conducted in accordance with oecd guideline no. 416 [oecd, 1983. guidelines for testing of chemicals, guideline no. 416. two generation reproduction toxicity study, adopted on 26th may 1983] and in compliance with good laboratory practices (o ... | 2007 | 16987575 |
| cumulative antioxidant defense against oxidative challenge in galactose-induced cataractogenesis in wistar rats. | natural dietary ingredients are known for their antioxidant activity. of such, curcumin, the active principle of turmeric, at 0.01% in the diet proved as pro-oxidative in galactose-induced cataract in vivo. the purpose of this study was to investigate the effect of vitamin e (ve), a well-known antioxidant, in combination with curcumin on the onset and maturation of galactose induced cataract. periodic slit-lamp microscope examination indicated that in combination with vitamin-e, 0.01% curcumin ( ... | 2006 | 16999028 |
| curcumin, the active principle of turmeric (curcuma longa), ameliorates diabetic nephropathy in rats. | chronic hyperglycaemia in diabetes leads to the overproduction of free radicals and evidence is increasing that these contribute to the development of diabetic nephropathy. among the spices, turmeric (curcuma longa) is used as a flavouring and colouring agent in the indian diet every day and is known to possess anti-oxidant properties. the present study was designed to examine the effect of curcumin, a yellow pigment of turmeric, on renal function and oxidative stress in streptozotocin (stz)-ind ... | 2006 | 17002671 |
| study on effects of extracts from salvia miltiorrhiza and curcuma longa in inhibiting phosphorylated extracellular signal regulated kinase expression in rat's hepatic stellate cells. | to study the effect of salvianolic acid b (sab) and curcumin, the extracts of salvia miltiorrhiza and curcuma longa, on the proliferation and activation of hepatic stellate cell (hsc), and the extracellular signal regulated kinase (erk) expression in it. | 2006 | 17005083 |
| effect of coating the wells of a polystyrene microtiter plate with xanthorrhizol on the biofilm formation of streptococcus mutans. | colonization on the surface of tooth by streptococcus mutans is an important step in the initiation of dental plaque. polystyrene microtiter plates have been employed to study bacterial colonization and biofilm formation of periodontal bacteria. the objective of this work was to evaluate the effect of coating the wells of a polystyrene microtiter plate with xanthorrhizol isolated from java turmeric (curcuma xanthorrhiza roxb.) on strep. mutans biofilm formation. our studies demonstrated that coa ... | 2006 | 17009296 |
| field evaluation of deet, repel care, and three plant based essential oil repellents against mosquitoes, black flies (diptera: simuliidae) and land leeches (arhynchobdellida: haemadipsidae) in thailand. | diethyl methyl benzamide, or deet, a commercial plant-based repellent (repel care), and essential ils from 3 species of plants (finger root rhizomes, guava leaves, and turmeric rhizomes), steam distillated and formulated as insect repellents, were evaluated in the field on human volunteers against hematophagous mosquitoes, black flies, and land leeches in thailand. field trials were conducted against wild mosquitoes in bang bua thong district, nonthaburi province, and in the thap lan national pa ... | 2006 | 17019778 |
| c-abl kinase regulates curcumin-induced cell death through activation of c-jun n-terminal kinase. | curcumin, a natural phenolic compound found in turmeric (curcuma longa) exhibits anticancer properties, attributed to its antiproliferative and apoptosis-inducing activity. the ubiquitously expressed nonreceptor tyrosine kinase c-abl regulates stress responses induced by oxidative agents such as ionizing radiation and h2o2. in this study, we show that c-abl is an important component of the cell death response activated by curcumin and that abl mediates this response partly through activation of ... | 2007 | 17021249 |
| curcumin reverses the effects of chronic stress on behavior, the hpa axis, bdnf expression and phosphorylation of creb. | curcuma longa is a major constituent of the traditional chinese medicine xiaoyao-san, which has been used to effectively manage stress and depression-related disorders in china. curcumin is the active component of curcuma longa, and its antidepressant effects were described in our prior studies in mouse models of behavioral despair. we hypothesized that curcumin may also alleviate stress-induced depressive-like behaviors and hypothalamic-pituitary-adrenal (hpa) axis dysfunction. thus in present ... | 2006 | 17022948 |
| multiple molecular targets in cancer chemoprevention by curcumin. | carcinogenesis encompasses 3 closely associated stages: initiation, progression, and promotion. phytochemicals are nonnutritive components of plants that are currently being studied in chemoprevention of various diseases for their pleiotropic effects and nontoxicity. cancer chemoprevention involves the use of either natural or synthetic chemicals to prevent the initiation, promotion, or progression of cancer. curcumin is the active constituent of turmeric, which is widely used as a spice in indi ... | 2006 | 17025261 |
| a 32-week randomized, placebo-controlled clinical evaluation of ra-11, an ayurvedic drug, on osteoarthritis of the knees. | the ancient indian (asian) ayurvedic medicinal system uses herbomineral drugs to treat arthritis. despite centuries of use, very few have been tested by drug trials. ra-11 (artrex, mendar), a standardized multiplant ayurvedic drug (withania somnifera, boswellia serrata, zingiber officinale, and curcuma longa) is currently used to treat arthritis. | 2004 | 17043520 |
| curcumin content of turmeric and curry powders. | curcumin, derived from the rhizome curcuma longa, is one of the primary ingredients in turmeric and curry powders that are used as spices in middle eastern and asian countries, especially on the indian subcontinent. more recently, laboratory studies have demonstrated that dietary curcumin exhibits various biological activities and significantly inhibits colon tumorigenesis and tumor size in animals. curcumin displays both anti-inflammatory and antioxidant properties, giving it the potential to b ... | 2006 | 17044766 |
| mechanisms of curcumin- and egf-receptor related protein (errp)-dependent growth inhibition of colon cancer cells. | numerous dietary and pharmacological agents have been proposed as alternative strategies for treatment and prevention of colorectal cancer. curcumin, an active ingredient of turmeric, that inhibits growth of malignant neoplasms, has a promising role in the prevention and treatment of colorectal cancer. egf-r related protein (errp), a recently identified pan-erbb inhibitor, is a potential therapeutic agent for colorectal cancer. here we examine whether curcumin together with errp will cause a gre ... | 2006 | 17044774 |
| comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine. | curcumin, a major constituent of the spice turmeric, suppresses expression of the enzyme cyclooxygenase 2 (cox-2) and has cancer chemopreventive properties in rodents. it possesses poor systemic availability. we explored whether formulation with phosphatidylcholine increases the oral bioavailability or affects the metabolite profile of curcumin. | 2007 | 17051370 |
| salmonella prevalence and total microbial and spore populations in spices imported to japan. | a total of 259 samples of 40 types of spices were tested for salmonella prevalence and total microbial and spore populations. salmonella enterica serotypes weltevreden and senftenberg were isolated from a black- and red-pepper sample, respectively. because salmonella was not detected by the most-probable-number method, it indicated that at least one cell of the microorganism was present in 25 g of sample. the mean aerobic bacterial count was greater than 5.39 log cfu/g in turmeric, garam masala, ... | 2006 | 17066938 |
| dietary antioxidant curcumin inhibits microtubule assembly through tubulin binding. | curcumin, a component of turmeric, has potent antitumor activity against several tumor types. however, its molecular target and mechanism of antiproliferative activity are not clear. here, we identified curcumin as a novel antimicrotubule agent. we have examined the effects of curcumin on cellular microtubules and on reconstituted microtubules in vitro. curcumin inhibited hela and mcf-7 cell proliferation in a concentration-dependent manner with ic(50) of 13.8 +/- 0.7 microm and 12 +/- 0.6 micro ... | 2006 | 17069615 |
| antimicrobial emulsion (coating) based on biopolymer containing neem (melia azardichta) and turmeric (curcuma longa) extract for wound covering. | polymeric bio-adhesives emulsion which is biodegradable and non-toxic containing antimicrobial agents can play an important role in preventing infection in wound covering and coating for surgical implants. therefore a bioadhesive polymer was synthesized by semi-interpenetrating network process using blend of shellac, casein and polyvinyl alcohol and maleic anhydride (ma) as reactive compatibilizer. the synthesized polymer was mixed with neem and turmeric extract and homogenized using an emulsifi ... | 2006 | 17075168 |
| efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis. | scientific evidence is lacking for the antiarthritic efficacy of turmeric dietary supplements that are being promoted for arthritis treatment. therefore, we undertook studies to determine the antiarthritic efficacy and mechanism of action of a well-characterized turmeric extract using an animal model of rheumatoid arthritis (ra). | 2006 | 17075840 |
| tetrahydrocurcumin: effect on chloroquine-mediated oxidative damage in rat kidney. | tetrahydrocurcumin is an antioxidative substance, which is derived from curcumin, the component of turmeric. in the present investigation, the effect of tetrahydrocurcumin and curcumin against chloroquine-induced nephrotoxicity were studied in female wistar rats. oral administration of tetrahydrocurcumin significantly prevented the occurrence of chloroquine (970 mg/kg body weight)-induced renal damage. upon administration of tetrahydrocurcumin to chloroquine-treated rats, the level of lipid pero ... | 2006 | 17076682 |
| curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. | curcumin is a biologically active phytochemical substance present in turmeric and has pharmacologic actions that might benefit patients with ulcerative colitis (uc). the aim in this trial was to assess the efficacy of curcumin as maintenance therapy in patients with quiescent ulcerative colitis (uc). | 2006 | 17101300 |
| curcumin/turmeric solubilized in sodium hydroxide inhibits hne protein modification--an in vitro study. | free radical mediated lipid peroxidation has been implicated in multiple diseases. a major oxidation by-product of this deleterious process is 4-hydroxy-2-nonenal (hne). hne is cytotoxic, mutagenic and genotoxic and is involved in disease pathogenesis. curcumin, a non-steroidal anti-inflammatory agent (occurring as the yellow pigment found in the rhizomes of the perennial herb curcuma longa known as turmeric), has emerged as the newest "nutraceutical" agent that has been shown to be efficacious ... | 2007 | 17116380 |
| chili, but not turmeric, inhibits iron absorption in young women from an iron-fortified composite meal. | chili and turmeric are common spices in indigenous diets in tropical regions. being rich in phenolic compounds, they would be expected to bind iron (fe)(3) in the intestine and inhibit fe absorption in humans. three experiments were conducted in healthy young women (n = 10/study) to assess the effect of chili and turmeric on fe absorption from a rice-based meal containing vegetables and iron fortified fish sauce in vivo. iron absorption was determined by erythrocyte incorporation of stable isoto ... | 2006 | 17116705 |
| effects of ingested turmeric oleoresin on glucose and lipid metabolisms in obese diabetic mice: a dna microarray study. | turmeric, the rhizome of curcuma longa l., has a wide range of effects on human health. turmeric oleoresin, an extract of turmeric, is often used for flavoring and coloring. curcuminoids and turmeric essential oil are both contained in turmeric oleoresin, and both of these fractions have hypoglycemic effects. in the present study, we comprehensively assessed the effect of turmeric oleoresin on hepatic gene expression in obese diabetic kk-ay mice using dna microarray analysis and quantitative rea ... | 2006 | 17117790 |
| mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders. | protein conformational diseases, such as alzheimer's, parkinson's and huntington's, affect a large portion of aging population. the pathogenic dysfunctional aggregation of proteins in non-native conformations is associated with metabolic derangements and excessive production of reactive oxygen species. reduction of cellular expression and activity of antioxidant proteins result in increased oxidative stress. free-radicals derived from mitochondrial dysfunction and from the cyclooxygenase enzyme ... | 2007 | 17127365 |
| behavioral, neurochemical and neuroendocrine effects of the ethanolic extract from curcuma longa l. in the mouse forced swimming test. | curcuma longa l. (turmeric) has been used for centuries in traditional chinese medicine as a treatment for mental disorders including depression. the studies described here were undertaken to determine the behavioral, neurochemical and neuroendocrine effects of the ethanolic extract from curcuma longa using the forced swimming test (fst) in male icr strain of mice. the ethanolic extract was found to reduce the duration of immobility in the mouse fst when orally administered for 21 days. the extr ... | 2007 | 17134862 |
| metabolic profiling of turmeric (curcuma longa l.) plants derived from in vitro micropropagation and conventional greenhouse cultivation. | turmeric (curcuma longa) was considered only a culinary spice in many parts of the world until the notable anti-inflammation curcuminoids were discovered from this herb. because it is a sterile triploid and is propagated vegetatively by rhizome division, turmeric is susceptible to pathogens that accumulate and are transmitted from generation to generation, and amplification of particularly useful stocks is a slow process. an in vitro propagation method has been developed to alleviate these probl ... | 2006 | 17147448 |
| contact urticaria from curcumin. | turmeric, a spice derived from the rhizome of the plant curcuma longa, contains the chemical curcumin, which is responsible for turmeric's taste, color, and biologic properties. curcumin is used as a spice in foods, as a treatment in traditional medicine, as a dye for fur, and as a component in nutritional supplements. a few cases of allergic contact dermatitis from curcumin have been reported. we report two cases of contact urticaria from curcumin. these cases are mediated by two different mech ... | 2006 | 17150169 |
| chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by map kinase phosphatase-5 in prostate cells. | as inflammation emerges as a risk factor for prostate cancer (pca), there is potential for chemoprevention by anti-inflammatory agents. dietary phytochemicals have been shown to have chemopreventive properties which may include anti-inflammatory activities. in this study, we demonstrate a role for mitogen-activated protein kinase phosphatase-5 (mkp5) in mediating anti-inflammatory activities of the phytochemicals curcumin, resveratrol and [6]-gingerol. we utilized the cytokines tumor necrosis fa ... | 2007 | 17151092 |
| curcumin enhances apo2l/trail-induced apoptosis in chemoresistant ovarian cancer cells. | curcumin, the active component of turmeric (curcuma longa), exhibits growth inhibitory activity against prostate, colon, and breast cancer; however, the effect of curcumin on ovarian cancer cells is not known. we hypothesized that curcumin could induce cell death in ovarian cancer cells, and enhance apoptosis induced by tumor necrosis factor-related apoptosis inducing apo2 ligand/trail. | 2007 | 17174384 |
| curcumin opens cystic fibrosis transmembrane conductance regulator channels by a novel mechanism that requires neither atp binding nor dimerization of the nucleotide-binding domains. | cystic fibrosis transmembrane conductance regulator (cftr) chloride channels are essential mediators of salt transport across epithelia. channel opening normally requires atp binding to both nucleotide-binding domains (nbds), probable dimerization of the two nbds, and phosphorylation of the r domain. how phosphorylation controls channel gating is unknown. loss-of-function mutations in the cftr gene cause cystic fibrosis; thus, there is considerable interest in compounds that improve mutant cftr ... | 2007 | 17178710 |
| spleen tyrosine kinase (syk), a novel target of curcumin, is required for b lymphoma growth. | curcumin (diferuloylmethane), a component of dietary spice turmeric (curcuma longa), has been shown in recent studies to have therapeutic potential in the treatment of cancer, diabetes, arthritis, and osteoporosis. we investigated the ability of curcumin to modulate the growth of b lymphomas. curcumin inhibited the growth of both murine and human b lymphoma in vitro and murine b lymphoma in vivo. we also demonstrate that curcumin-mediated growth inhibition of b lymphoma is through inhibition of ... | 2007 | 17182546 |
| redox regulation of cellular stress response in aging and neurodegenerative disorders: role of vitagenes. | reduced expression and/or activity of antioxidant proteins lead to oxidative stress, accelerated aging and neurodegeneration. however, while excess reactive oxygen species (ros) are toxic, regulated ros play an important role in cell signaling. perturbation of redox status, mutations favoring protein misfolding, altered glyc(osyl)ation, overloading of the product of polyunsaturated fatty acid peroxidation (hydroxynonenals, hne) or cholesterol oxidation, can disrupt redox homeostasis. collectivel ... | 2016 | 17191135 |
| curcumin-induced cell cycle arrest and apoptosis in human acute promyelocytic leukemia hl-60 cells via mmp changes and caspase-3 activation. | curcumin (diferuloylmethane), is a natural product derived from the root of the plant curcuma longa. for centuries, it has been used as a spice and as a herbal medicine in chinese populations. curcumin has been shown to inhibit cell proliferation, cell cycle arrest, cyclooxygenase (cox)-1 and -2 expression and apoptosis in several human cancer cell lines. the aim of this investigation was to clarify the mechanisms by which curcumin induced cytotoxicity and apoptosis in human leukemia hl-60 cells ... | 2006 | 17201156 |
| curcumin-induced apoptosis of human colon cancer colo 205 cells through the production of ros, ca2+ and the activation of caspase-3. | curcumin (diferuloylmethane), the yellow pigment in turmeric (curcuma longa), is known to inhibit proliferation of cancer cells by arresting them at various phases of the cell cycle and to induce apoptosis in tumor cells. curcumin-induced apoptosis mainly involves the activation of caspase-3 and mitochondria-mediated pathway in various cancer cells of different tissue origin. in the present study, the induction of apoptosis and cytotoxicity by curcumin in colon cancer colo 205 cells was investig ... | 2006 | 17201158 |
| synthesis of novel curcumin analogues and their evaluation as selective cyclooxygenase-1 (cox-1) inhibitors. | curcumin, a major yellow pigment and active component of turmeric, has been shown to possess anti-inflammatory and anti-cancer activities. recent studies have indicated that cyclooxygenase-1 (cox-1) plays an important role in inflammation and carcinogenesis. in order to find more selective cox-1 inhibitors a series of novel curcumin derivatives was synthesized and evaluated for their ability to inhibit this enzyme using in vitro inhibition assays for cox-1 and cox-2 by measuring pge(2) productio ... | 2007 | 17202703 |
| "spicing up" of the immune system by curcumin. | curcumin (diferuloylmethane) is an orange-yellow component of turmeric (curcuma longa), a spice often found in curry powder. traditionally known for its an antiinflammatory effects, curcumin has been shown in the last two decades to be a potent immunomodulatory agent that can modulate the activation of t cells, b cells, macrophages, neutrophils, natural killer cells, and dendritic cells. curcumin can also downregulate the expression of various proinflammatory cytokines including tnf, il-1, il-2, ... | 2007 | 17211725 |