Publications

turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: a pilot study.	to assess the effects of turmeric (curcuma longa) extract on irritable bowel syndrome (ibs) symptomology in otherwise healthy adults.	2004	15673996
[preparative separation of curcumin from turmeric by column chromatography].		2004	15709435
curcuminoids and sesquiterpenoids in turmeric (curcuma longa l.) suppress an increase in blood glucose level in type 2 diabetic kk-ay mice.	turmeric, the rhizome of curcuma longa l., has a wide range of effects on human health. the chemistry includes curcuminoids and sesquiterpenoids as components, which are known to have antioxidative, anticarcinogenic, and antiinflammatory activities. in this study, we investigated the effects of three turmeric extracts on blood glucose levels in type 2 diabetic kk-a(y) mice (6 weeks old, n = 5/group). these turmeric extracts were obtained by ethanol extraction (e-ext) to yield both curcuminoids a ...	2005	15713005
antiangiogenic agents: studies on fumagillin and curcumin analogs.	cancer is a general term used to describe many disease states, each of which are characterized by abnormal cell proliferation. the causes which bring about this abnormal cellular behavior are specific to each type of cancer. the success of tumor-targeted therapy is limited by this diversity. one common denominator for all types of cancer is the requirement of a suitable blood supply. therefore, tumor vasculature has emerged as a potential target for therapeutic intervention. new blood vessel gro ...	2005	15723631
astrocyte production of the chemokine macrophage inflammatory protein-2 is inhibited by the spice principle curcumin at the level of gene transcription.	background: in neuropathological processes associated with neutrophilic infiltrates, such as experimental allergic encephalitis and traumatic injury of the brain, the cxc chemokine, macrophage inflammatory protein-2 (mip-2) is thought to play a pivotal role in the induction and perpetuation of inflammation in the central nervous system (cns). the origin of mip-2 in inflammatory disorders of the brain has not been fully defined but astrocytes appear to be a dominant source of this chemokine.curcu ...	2005	15733321
curcumin overcomes the inhibitory effect of nitric oxide on leishmania.	upon leishmania infection, macrophages are activated to produce nitrogen and oxygen radicals simultaneously. it is well established that the infected host cells rely on nitric oxide (no) as the major weapon against the intracellular parasite. in india where leishmaniasis is endemic, the spice turmeric is used prolifically in food and for insect bites. curcumin, the active principle of turmeric, is a scavenger of no. this report shows that curcumin protects promastigotes and amastigotes of the vi ...	2005	15772867
design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agents.	curcuminoids were isolated from curcuma longa and their pyrazole and isoxazole analogues were synthesized and evaluated for antioxidant, cox-1/cox-2 inhibitory and anti-inflammatory activities. the designed analogues significantly enhance cox-2/cox-1 selectivity and possess significant anti-inflammatory activity in carrageenan induced rat paw edema assay. pyrazole, isoxazole analogues of curcumin (4 and 7) exhibited higher antioxidant activity than trolox. molecular docking study revealed the bi ...	2005	15780608
curcumin-induced histone hypoacetylation: the role of reactive oxygen species.	curcumin (cur), a well-known dietary pigment derived from curcuma longa, is a promising anticancer drug, but its in vivo target molecules remain to be clarified. here we report that exposure of human hepatoma cells to cur led to a significant decrease of histone acetylation. histone acetyltransferase (hat) and histone deacetylase (hdac) are the enzymes controlling the state of histone acetylation in vivo. cur treatment resulted in a comparable inhibition of histone acetylation in the absence or ...	2005	15794941
nutraceuticals as anti-angiogenic agents: hopes and reality.	angiogenesis, the formation of new blood vessels from preexisting vascular network is a driving force of organ development in ontogeny, is necessary for ovulation and hair growth, and is prerequisite for proper wound healing. it is also a critical mechanism of numerous diseases, the most important of which are cancer and atherosclerosis. therefore, modulation of angiogenesis is considered as therapeutic strategies of great importance for human health. numerous bioactive plant compounds, often re ...	2005	15800385
[determination of curcumin in urine by capillary electrophoresis].	the major component of the plant curcuma longa (a widely cultivated tropical plant in asia and central america) is curcumin. curcumin has been reported to have very strong anti-inflammatory, anti-carcinogenic, anti-oxidant, antiallergic, anti-bacterial, and anti-tumor activities. little is known about the absorption, distribution, and metabolism of curcumin in human beings. the first step in in vivo physiological and pharmacokinetic studies is to develop a method to measure curcumin in body flui ...	2004	15807112
inhibition of nad(p)h:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin.	nad(p)h:quinone oxidoreductase 1 (nqo1) regulates the stability of the tumor suppressor wt p53. nqo1 binds and stabilizes wt p53, whereas nqo1 inhibitors including dicoumarol and various other coumarins and flavones induce ubiquitin-independent proteasomal p53 degradation and thus inhibit p53-induced apoptosis. here, we show that curcumin, a natural phenolic compound found in the spice turmeric, induced ubiquitin-independent degradation of wt p53 and inhibited p53-induced apoptosis in normal thy ...	2005	15809436
biological effects of indigenous medicinal plants curcuma longa and alpinia galanga.	the ethanolic extracts of curcuma longa and alpinia galanga exhibited excellent (100%) phytotoxic activity against lemma minor. these extracts were also found to possess good antifungal activities against trichophyton longifusus (65% and 60%, respectively), while in the brine shrimp lethality bioassay were found to be toxic with ld50 of 33 and 109 mincrog/ml, respectively. these extracts were found quite inert in antibacterial bioassay, while the extract from c. longa, tested for insecticidal ac ...	2005	15810156
[effects of seeding and sowing methods on the yields of root tubers of curcuma longa].	to provide a scientific basis for standardizing the cultivation method for curcuma longa.	2005	15810443
induction of apoptosis by curcumin and its implications for cancer therapy.	curcumin (diferuloyl methane), the yellow pigment in turmeric (curcuma longa), is a potent chemopreventive agent that inhibits proliferation of cancer cells by arresting them at various phases of the cell cycle depending upon the cell type. curcumin-induced apoptosis mainly involves the mitochondria-mediated pathway in various cancer cells of different tissues of origin. in some cell types like thymocytes, curcumin induces apoptosis-like changes whereas in many other normal and primary cells cur ...	2005	15810876
ayurveda and yoga in cardiovascular diseases.	ayurveda is derived from 2 sanskrit words, namely, "ayus" and "veda," meaning life and knowledge, respectively. it literally means science of life. ayurveda, of which yoga is an integral part, is widely practiced in india and is gaining acceptance in many countries around the world. it is a comprehensive and a holistic system, the focus of which is on the body, mind, and consciousness. the ayurvedic treatment consists of the use herbal preparations, diet, yoga, meditation, and other practices. b ...	2005	15831140
ayurveda and yoga in cardiovascular diseases.	ayurveda is derived from 2 sanskrit words, namely, "ayus" and "veda," meaning life and knowledge, respectively. it literally means science of life. ayurveda, of which yoga is an integral part, is widely practiced in india and is gaining acceptance in many countries around the world. it is a comprehensive and a holistic system, the focus of which is on the body, mind, and consciousness. the ayurvedic treatment consists of the use herbal preparations, diet, yoga, meditation, and other practices. b ...	2007	15834238
pharmacological basis for the use of turmeric in gastrointestinal and respiratory disorders.	this study was carried out to provide scientific basis for the medicinal use of turmeric (curcuma longa) in gastrointestinal and respiratory disorders. the crude extract of turmeric (cl.cr), relaxed the spontaneous and k+ (80 mm)-induced contractions in isolated rabbit jejunum as well as shifted the cacl2 concentration-response curves. in rabbit tracheal preparation, cl.cr inhibited carbachol and k(+)-induced contractions. in anesthetized rats, cl.cr produced variable responses on blood pressure ...	2005	15850601
anti-oxidant activities of curcumin and related enones.	the natural product curcumin (diferuloylmethane, 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), obtained from the spice turmeric, exhibits numerous biological activities including anti-cancer, anti-inflammatory, and anti-angiogenesis activities. some of these biological activities may derive from its anti-oxidant properties. there are conflicting reports concerning the structural/electronic basis of the anti-oxidant activity of curcumin. curcumin is a symmetrical diphenolic dienon ...	2005	15863007
hypoglycemic effects of turmeric (curcuma longa l. rhizomes) on genetically diabetic kk-ay mice.	the turmeric (curcuma longa l. rhizomes) etoh extract significantly suppressed an increase in blood glucose level in type 2 diabetic kk-a(y) mice. in an in vitro evaluation, the extract stimulated human adipocyte differentiation in a dose-dependent manner and showed human peroxisome proliferator-activated receptor (ppar)-gamma ligand-binding activity in a gal4-ppar-gamma chimera assay. the main constituents of the extract were identified as curcumin, demethoxycurcumin, bisdemethoxycurcumin, and ...	2005	15863912
plant medicines of indian origin for wound healing activity: a review.	research on wound healing drugs is a developing area in modern biomedical sciences. scientists who are trying to develop newer drugs from natural resources are looking toward the ayurveda, the indian traditional system of medicine. several drugs of plant, mineral, and animal origin are described in the ayurveda for their wound healing properties under the term vranaropaka. most of these drugs are derived from plant origin. some of these plants have been screened scientifically for the evaluation ...	2003	15866825
thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity.	the thioredoxin reductase (trxr) isoenzymes, trxr1 in cytosol or nucleus and trxr2 in mitochondria, are essential mammalian selenocysteine (sec)-containing flavoenzymes with a -gly-cys-sec-gly active site. trxrs are the only enzymes catalyzing the nadph-dependent reduction of the active site disulfide in thioredoxins (trxs), which play essential roles in substrate reductions, defense against oxidative stress, and redox regulation by thiol redox control. trxrs have been found to be overexpressed ...	2005	15879598
protective effect of curcumin during selenium induced toxicity on dehydrogenases in hepatic tissue.	selenium administration resulted in a marked decrease in the activity levels of the liver succinate dehydrogenase, malate dehydrogenase, and lactate dehydrogenase while pyruvate dehydrogenase increased significantly (p<0.001) in the wistar rat. the degree of decrease of these enzymes was significantly less (p<0.001) when rats were treated with curcumin, a natural constituent curcuma longa. curcumin seems to prevent oxidative damage mediated through selenium and protect the dehydrogenases possibl ...	2005	15881869
curcumin prevents methylglyoxal-induced oxidative stress and apoptosis in mouse embryonic stem cells and blastocysts.	methylglyoxal (mg) is a reactive dicarbonyl compound endogenously produced mainly from glycolytic intermediates. elevated mg levels in diabetes patients are believed to contribute to diabetic complications. mg is cytotoxic through induction of apoptosis. curcumin, the yellow pigment of curcuma longa, is known to have antioxidant and anti-inflammatory properties. in the present study, we examined the effect of curcumin on apoptotic biochemical events caused by incubation of esc-b5 cells with mg. ...	2005	15887245
[clinical study on comprehensive treatment of primary liver cancer mainly with chinese medicinal perfusion/embolization].	to study the clinical efficacy and adverse reaction of comprehensive therapy mainly with chinese anti-cancer medicinal perfusion/embolization and assisted with chinese drug-therapy based on tcm syndrome differentiation in treating primary liver cancer.	2005	15892270
chemopreventive and therapeutic effects of curcumin.	chemoprevention is a promising anti-cancer approach with reduced secondary effects in comparison to classical chemotherapy. curcumin, one of the most studied chemopreventive agents, is a natural compound extracted from curcuma longa l. that allows suppression, retardation or inversion of carcinogenesis. curcumin is also described as an anti-tumoral, anti-oxidant and anti-inflammatory agent capable of inducing apoptosis in numerous cellular systems. in this review, we describe both properties and ...	2005	15896452
application of capillary zone electrophoresis in the separation and determination of the curcuminoids in urine.	the major components of the plant curcuma longa are the curcuminoids that include curcumin, demethoxycurcumin and bisdemethoxycurcumin. it has been reported the curcuminoids have some important activities. a new cze method with diode array detection has been developed for the separation and determination of the curcumin, demethoxycurcumin and bisdemethoxycurcumin. three curcuminoids could be readily separated within 7 min with a 15 mm sodium tetraborate buffer containing 10% methanol (v/v) at ph ...	2005	15907631
screening of plants containing naja naja siamensis cobra venom inhibitory activity using modified elisa technique.	enzyme-linked immunosorbent assay (elisa) has been modified for screening plants with antagonistic activity to naja naja siamensis cobra venom. aqueous extracts from plants were investigated for their inhibitory effects on the binding of anti-cobra venom antibody to antigen, cobra venom, fixed onto 96-well microtiter plates. ingredients in extracts were allowed to react with immobilized venom before the subsequent addition of antivenom antibody. venom components affected by exposure to the extra ...	2005	15907878
synthesis and biological evaluation of aromatic enones related to curcumin.	curcumin, a natural product isolated from the spice turmeric, has been shown to exhibit a wide range of pharmacological activities including certain anti-cancer properties. it has been specifically shown to be an effective inhibitor of angiogenesis both in vitro and in vivo. using curcumin as a lead compound for anti-angiogenic analog design, a series of structurally related compounds utilizing a substituted chalcone backbone have been synthesized and tested via an established svr cell prolifera ...	2005	15911313
curcumin and turmeric delay streptozotocin-induced diabetic cataract in rats.	the purpose of this study was to investigate the effect of curcumin and its source, turmeric, on streptozotocin-induced diabetic cataract in rats.	2005	15914628
curcumin blocks hiv protease inhibitor ritonavir-induced vascular dysfunction in porcine coronary arteries.	hiv protease inhibitor ritonavir (rtv) is associated with many cardiovascular complications and causes vascular dysfunction through oxidative stress. in the present study, we determined the effects of rtv and curcumin (a pigment derived from turmeric) on porcine coronary arteries.	2005	15922191
the anti-inflammatory compound curcumin inhibits neisseria gonorrhoeae-induced nf-kappab signaling, release of pro-inflammatory cytokines/chemokines and attenuates adhesion in late infection.	neisseria gonorrhoeae (ngo) is a gram-negative pathogenic bacterium responsible for an array of diseases ranging from urethritis to disseminated gonococcal infections. early events in the establishment of infection involve interactions between ngo and the mucosal epithelium, which induce a local inflammatory response. here we analyzed the molecular mechanism involved in the ngo-induced induction of the proinflammatory cytokines tumor necrosis factor alpha (tnfalpha), interleukin-6 (il-6), and il ...	2005	15927892
protective role of tetrahydrocurcumin (thc) an active principle of turmeric on chloroquine induced hepatotoxicity in rats.	purpose: tetrahydrocurcumin (thc) is an antioxidative substance, which is derived from curcumin, the component of turmeric. in the present investigation, the effect of thc and curcumin against chloroquine (cq) induced hepatotoxicity were studied in female wistar rats. methods: on single oral administration of cq (970 mg/kg body weight) the activities of serum marker enzymes namely aspartate transaminase, alanine transaminase and alkaline phosphatase and the levels of bilirubin were significantly ...	2005	15946605
antiatherosclerotic effects of dietary supplementations of garlic and turmeric: restoration of endothelial function in rats.	protections of endothelial integrity by elimination of certain risk have proven to be effective in maintaining hemostasis and in slowing the progress of the cardiovascular disease. indigenous drugs are the natural source of protection against these disorders, which can be used more effectively by the knowledge of their active ingredients as well as by their mechanism of action. most prominent among these drugs are garlic, [alium sativum l., family: liliaceae, bulbs] and turmeric [curcuma longa l ...	2005	15964306
curcumin inhibits ros formation and apoptosis in methylglyoxal-treated human hepatoma g2 cells.	methylglyoxal (mg) is a reactive dicarbonyl compound endogenously produced mainly from glycolytic intermediates. elevated mg levels in diabetes patients are believed to contribute to diabetic complications. mg is cytotoxic through induction of apoptosis. curcumin, the yellow pigment of curcuma longa, is known to have antioxidant and anti-inflammatory properties. in the present study, we investigated the effect of curcumin on mg-induced apoptotic events in human hepatoma g2 cells. we report that ...	2005	15965083
the effects of curcumin on depressive-like behaviors in mice.	curcuma longa is a major constituent of xiaoyao-san, the traditional chinese medicinal formula, which has been used effectively to treat depression-related diseases in china. there is no information available about the antidepressant activity of curcumin, the active component of curcuma longa. in the present study, we analyzed the effects of curcumin on depressive-like behaviors in mice, using two animal models of depression. our results showed that curcumin treatment at 5 and 10 mg/kg (p.o.) si ...	2005	15987635
curcumin attenuates diet-induced hypercholesterolemia in rats.	curcumin (a component of turmeric) has long been used as a spice and food-coloring agent. in experimental animals, curcumin has shown anti-diabetic, anti-inflammatory, cytotoxic and anti-oxidant properties.	2005	15990684
the effect of turmeric extracts on inflammatory mediator production.	major compounds of several commonly used botanicals, including turmeric, have been purported to have anti-inflammatory actions. in order to test the anti-inflammatory activity of compounds isolated from rhizomes of curcuma longa l. (zingiberaceae), we have established an in vitro test system. hl-60 cells were differentiated and exposed to lipopolysaccharide (lps) from escherichia coli (1 microg/ml) in the presence or absence of botanical compounds for 24 h. supernatants were collected and analyz ...	2005	16008121
chemopreventive effects of embelin and curcumin against n-nitrosodiethylamine/phenobarbital-induced hepatocarcinogenesis in wistar rats.	the effects of embelin (50 mg/kg/day), a benzoquinone derivative of embelia ribes, and the effects of curcumin (100 mg/kg/day), the active principle of curcuma longa, against n-nitrosodiethylamine (dena)-initiated and phenobarbital (pb)-promoted hepatocarcinogenesis were studied in wistar rats. they were able to prevent the induction of hepatic hyper plastic nodules, body weight loss, increase in the levels of hepatic diagnostic markers, and hypoproteinemia induced by dena/pb treatment. hence, r ...	2005	16009505
in vitro enzyme inhibition activities of crude ethanolic extracts derived from medicinal plants of pakistan.	twenty two crude ethanolic extracts from 14 indigenous medicinal plants were subjected to enzyme inhibition screening against acetylcholinesterase (ache), butyrylcholinesterase (bche) and lipoxygenase enzymes (lo). three extracts showed activity against ache, nine extracts were found to be active against bche and four extracts inhibited the enzyme lo. the most significant inhibition activities (> or =50%) were found in extracts derived from aloe vera (leaves), alpinia galanga (rhizome), curcuma ...	2005	16010821
curcumin has a palliative action on gentamicin-induced nephrotoxicity in rats.	generation of free radicals in kidney cortex plays an important role in the pathogenesis of gentamicin (gm) nephrotoxicity, and curcumin, the yellow curry pigment isolated from turmeric, has been confirmed to have a strong antioxidant action. therefore, in the present work, we aimed at testing the possible protective or palliative effect of curcumin on gm nephrotoxicity. curcumin was given to rats at an oral dose of 200 mg/kg/day for 10 days, and in some of these rats gm was also injected intram ...	2005	16011735
curcuminoids purified from turmeric powder modulate the function of human multidrug resistance protein 1 (abcc1).	multidrug resistance is a major cause of chemotherapy failure in cancer patients. one of the resistance mechanisms is the overexpression of drug efflux pumps such as p-glycoprotein and multidrug resistance protein 1 (mrp1, (abcc1)). in this study, curcumin mixture and three major curcuminoids purified from turmeric (curcumin i, ii, and iii) were tested for their ability to modulate the function of mrp1 using hek293 cells stably transfected with mrp1-pcdna3.1 and pcdna3.1 vector alone. the ic(50) ...	2006	16021489
modulatory effect of fenugreek seed mucilage and spent turmeric on intestinal and renal disaccharidases in streptozotocin induced diabetic rats.	to elucidate the effect of feeding fenugreek seed mucilage and spent turmeric (10%) on disaccharidases activities, the specific activities of intestinal and renal disaccharidases viz., sucrase, maltase and lactase were measured in streptozotocin induced diabetic rats. specific activities of intestinal disaccharidases were increased significantly during diabetes and amelioration of these activities during diabetes was clearly visible by supplementing fenugreek seed mucilage and spent turmeric in ...	2005	16021836
alcoholic turmeric extract simultaneously activating murine lymphocytes and inducing apoptosis of ehlrich ascitic carcinoma cells.	in the present investigation ethanolic turmeric extract has been found to play diabolically opposite role on murine lymphocytes and on ehlrich ascitic carcinoma cells. turmeric stimulates the lymphocytes into the effector pathway as studied through in vitro viability, blastogenesis and (3)h-tdr incorporation and also seems to be healthy under scanning electron microscopy (sem). sem revealed the formation of cytoplasmic blebs and plasma membrane disintegration of tumor cells with ethanolic turmer ...	2005	16023609
a hplc method for the analysis of germacrone in rabbit plasma and its application to a pharmacokinetic study of germacrone after administration of zedoary turmeric oil.	a validated new, simple and highly sensitive reversed-phase hplc method is developed for studying the pharmacokinetics of germacrone after intravenous administration of zedoary turmeric oil (zto) oil-in-water microemulsion. the method did not require a complex and expensive equipment. a high extraction recovery (>80%) of germacrone was obtained. linear calibration curves obtained with the peak-area ratio (y) of germacrone to internal standard (tanshinoneiia) versus drug concentration (x) were fo ...	2005	16029964
protective role of antioxidative food factors in oxidative stress caused by hyperglycemia.	hyperglycemia causes the autoxidation of glucose, glycation of proteins, and the activation of polyol metabolism. these changes accelerate generation of reactive oxygen species (ros) and increases in oxidative chemical modification of lipids, dna, and proteins in various tissues. oxidative stress may play an important role in the development of complications in diabetes such as lens cataracts, nephropathy, and neuropathy. glycation reactions, especially maillard reactions, occur in vivo as well ...	2005	16037265
curcumin derivatives inhibit the formation of jun-fos-dna complex independently of their conserved cysteine residues.	curcumin, a major active component of turmeric, has been identified as an inhibitor of the transcriptional activity of activator protein-1 (ap-1). recently, it was also found that curcumin and synthetic curcumin derivatives can inhibit the binding of jun-fos, which are the members of the ap-1 family, to dna. however, the mechanism of this inhibition by curcumin and its derivatives was not disclosed. since the binding of jun-fos dimer to dna can be modulated by redox control involving conserved c ...	2005	16053715
curcumin treatment protects rat retinal neurons against excitotoxicity: effect on n-methyl-d: -aspartate-induced intracellular ca(2+) increase.	curcumin, an extract from the plant curcuma longa with well-known antioxidant and anti-inflammatory activities, was tested as protective agent against excitotoxicity in rat retinal cultures. a 24 h-treatment with curcumin reduced n-methyl-d: -aspartate (nmda)-mediated excitotoxic cell damage, estimated as decrease of cell viability and increase in apoptosis. the protection was associated with decrease of nmda receptor-mediated ca(2+) rise and reduction in the level of phosphorylated nr1 subunit ...	2005	16078027
curcumin: the story so far.	curcumin is a polyphenol derived from the herbal remedy and dietary spice turmeric. it possesses diverse anti-inflammatory and anti-cancer properties following oral or topical administration. apart from curcumin's potent antioxidant capacity at neutral and acidic ph, its mechanisms of action include inhibition of several cell signalling pathways at multiple levels, effects on cellular enzymes such as cyclooxygenase and glutathione s-transferases, immuno-modulation and effects on angiogenesis and ...	2005	16081279
curcumin suppresses interleukin 1beta-mediated microsomal prostaglandin e synthase 1 by altering early growth response gene 1 and other signaling pathways.	curcumin (diferuloylmethane) is one of the phytophenolic compounds found in the turmeric plant with anti-inflammatory and anticarcinogenic activities. one possible mechanism for these activities is the inhibition of prostaglandin (pg) e(2) formation. in this study and other reports, curcumin suppresses interleukin-1beta-induced formation of prostaglandin e(2) in a concentration-dependent manner. interleukin-1beta-induced microsomal prostaglandin e synthase 1 (mpges-1) and cyclooxygenase-2 were a ...	2005	16081677
expression profiles of apoptotic genes induced by curcumin in human breast cancer and mammary epithelial cell lines.	curcumin (diferuloyl methane), the yellow-colored dietary pigment from the rhizomes of turmeric, has been recognized as a chemopreventive agent because of its antitumor, antioxidant and antiproliferative effects. the cytotoxic, apoptotic and gene regulatory effects of both turmeric and curcumin were investigated in the mcf-7 human breast cancer carcinoma cell line and compared with the effects in mcf-10a human mammary epithelial cells. mcf-7 cells were more sensitive to turmeric and curcumin tha ...	2005	16101141
effect of dianex, a herbal formulation on experimentally induced diabetes mellitus.	dianex, a polyherbal formulation consisting of the aqueous extracts of gymnema sylvestre, eugenia jambolana, momordica charantia azadirachta indica, cassia auriculata, aegle marmelose, withania somnifera and curcuma longa was screened for hypoglycemic activity in normal and streptozotocin induced diabetic mice. dianex was administered in different doses of 100-500 mg/kg/day orally in acute (6 h) and long-term (6 weeks) studies. blood glucose levels were checked 2-6 h after treatment in acute stu ...	2005	16106394
curcumin (diferuloylmethane) inhibits constitutive active nf-kappab, leading to suppression of cell growth of human t-cell leukemia virus type i-infected t-cell lines and primary adult t-cell leukemia cells.	adult t-cell leukemia (atl) is a fatal malignancy of t lymphocytes caused by infection with human t-cell leukemia virus type i (htlv-i) and remains incurable. curcumin (diferuloylmethane), the major pigment of the spice turmeric, can be potentially effective by promoting cell apoptosis. here we examined whether curcumin is effective in the treatment of atl. curcumin prevented cell growth of htlv-i-infected t-cell lines and primary atl cells but not of normal peripheral blood mononuclear cells. c ...	2006	16106398
evaluation of a new copper(ii)-curcumin complex as superoxide dismutase mimic and its free radical reactions.	a mononuclear (1:1) copper complex of curcumin, a phytochemical from turmeric, was synthesized and examined for its superoxide dismutase (sod) activity. the complex was characterized by elemental analysis, ir, nmr, uv-vis, epr, mass spectroscopic methods and tg-dta, from which it was found that a copper atom is coordinated through the keto-enol group of curcumin along with one acetate group and one water molecule. cyclic voltammetric studies of the complex showed a reversible cu(2+)/cu(+) couple ...	2005	16109310
antiplatelet property of curcuma longa l. rhizome-derived ar-turmerone.	the antiplatelet activities of curcuma longa l. rhizome-derived materials were measured using a platelet aggregometer and compared with those of aspirin as antiplatelet agent. the active constituent from the rhizome of curcuma longa l. was isolated and characterized as ar-turmerone by various spectral analyses. at 50% inhibitory concentration (ic50) value, ar-turmerone was effective in inhibiting platelet aggregation induced by collagen (ic50, 14.4 microm) and arachidonic acid (ic50, 43.6 microm ...	2006	16112857
comparative effects of curcumin and its analog on alcohol- and polyunsaturated fatty acid-induced alterations in circulatory lipid profiles.	excessive alcohol intake induces hyperlipidemia. studies suggest that natural principles and their analogs are known to possess anti-hyperlipidemic properties. in the present work we tested the effect of curcumin, an active principle of turmeric (curcuma longa), and a curcumin analog on alcohol- and thermally oxidized polyunsaturated fatty acid (deltapufa)- induced hyperlipidemia. male albino wistar rats were used for the experimental study. anti-hyperlipidemic activity of curcumin and curcumin ...	2005	16117621
effects of dietary curcumin or n-acetylcysteine on nf-kappab activity and contractile performance in ambulatory and unloaded murine soleus.	unloading of skeletal muscle causes atrophy and loss of contractile function. in part, this response is believed to be mediated by the transcription factor nuclear factor-kappa b (nf-kappab). both curcumin, a component of the spice turmeric, and n-acetylcysteine (nac), an antioxidant, inhibit activation of nf-kappab by inflammatory stimuli, albeit by different mechanisms. in the present study, we tested the hypothesis that dietary curcumin or nac supplementation would inhibit unloading-induced n ...	2005	16124875
curcumin suppresses constitutive activation of ap-1 by downregulation of jund protein in htlv-1-infected t-cell lines.	activation of the activator protein 1 (ap-1) plays a critical role in oncogenesis by human t-cell leukemia virus type 1 (htlv-1), the etiologic agent of adult t-cell leukemia (atl), and is required for maintenance of the malignant phenotype. curcumin (diferuloylmethane), the major pigment of the spice turmeric, has anti-tumor activity; however, the effect of curcumin against atl has not been elucidated. in this study, we examined the effects of curcumin on ap-1 activity in htlv-1-infected t-cell ...	2006	16157375
antibacterial activity of curcuma longa l. against methicillin-resistant staphylococcus aureus.	methicillin-resistant staphylococcus aureus (mrsa) has been emerging worldwide as one of the most important hospital and community pathogens. therefore, new agents are needed to treat mrsa associated infections. the present study investigated the antimicrobial activity of ethyl acetate, methanol and water extracts of curcuma longa l. (c. longa) against mrsa. the ethyl acetate extract of c. longa demonstrated a higher antibacterial activity than the methanol extract or water extract. since the et ...	2005	16161063
curcumin inhibits human colon cancer cell growth by suppressing gene expression of epidermal growth factor receptor through reducing the activity of the transcription factor egr-1.	high expression of epidermal growth factor receptor (egfr) is found in a variety of solid tumors, including colorectal cancer. egfr has been identified as a rational target for anticancer therapy. curcumin, the yellow pigment of turmeric in curry, has received attention as a promising dietary supplement for cancer prevention and treatment. we recently reported that curcumin inhibited the growth of human colon cancer-derived moser cells by suppressing gene expression of cyclind1 and egfr. the aim ...	2006	16170359
antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats.	curcuma longa is a major constituent of xiaoyao-san, the traditional chinese medicinal formula, which has been used to effectively manage stress and depression-related disorders in china. curcumin is the active component of curcuma longa, and we hypothesized that curcumin would have an influence on depressive-like behaviors. the purpose of the present study was to confirm the putative antidepressant effect of chronic administrations of curcumin (1.25, 2.5, 5 and 10 mg/kg, p.o.) in the forced swi ...	2005	16171853
efficiency of foam fractionation for the enrichment of nonpolar compounds from aqueous extracts of plant materials.	biologically active compounds from several useful plants were enriched using foam fractionation, a separatory method belonging to the adsorptive bubble separation (abs). nonpolar humulones (1-6) from pilsener beer, curcuminoids (7-9) from turmeric, and carotenoids (16 and 17) from carrot juice were enriched fast and quantitatively, depending on the process parameters, whereas more polar compounds such as catechins from green tea (11, 12, 14, and 15) and naringin (18) and hesperidin (19) from ora ...	2005	16180819
effect of tetrahydrocurcumin on erythromycin estolate-induced lipid peroxidation in rats.	erythromycin estolate (eme), a potent macrolide antibiotic, generates free radicals, but their role in the development of liver toxicity is not yet well understood. the present study was carried out to investigate the effect of the antioxidant drug tetrahydrocurcumin (a metabolite of curcumin, the main component of turmeric) against eme-induced lipid peroxidation in rats. the oral administration of combined thc (80 mg/kg body weight) and eme (800 mg/kg body weight) for 15 days significantly decr ...	2005	16187483
inhibition of cellular proliferation and induction of apoptosis by curcumin in human malignant astrocytoma cell lines.	nuclear factor (nf)-kappab is known to control cellular proliferation and apoptosis. in malignant astrocytoma cells, it was reported that nf-kappab was activated aberrantly and promoted their proliferation. thus, inhibition of nf-kappab activity is considered to be a promising therapeutic strategy for malignant astrocytoma. recently, curcumin, the major constituent of turmeric, was reported to inhibit nf-kappab activity. in this study, we investigated inhibitory effects of curcumin on nf-kappab ...	2005	16193380
radioprotection of turmeric extracts in bacterial system.	the present study investigates the possible role of crude turmeric extracts in radioprotection by a variety of methods. although curcumin, the main bioactive component of turmeric, has been extensively used in such studies, the efficiency of the crude extracts has been poorly investigated. this study revealed that dimethyl sulfoxide (dmso) extracts of turmeric produces a significant amount of radioprotection, which is very similar in nature and extent to that imparted by curcumin. field inversio ...	2005	16196208
effects of water-soluble antioxidants and mapkk/mek inhibitor on curcumin-induced apoptosis in hl-60 human leukemic cells.	curcumin is the main biologically active phytochemical compound in turmeric. it has been shown to have anticarcinogenic activity. the aims of the study were to identify the mechanism of apoptosis of hl-60 human promyelocytic leukemic cells induced by curcumin and to determine the effects of water-soluble antioxidants, ascorbic acid, trolox (a water-soluble form of vitamin e), glutathione (gsh) and n-acetylcysteine (nac) on this process. hl-60 cells were incubated with curcumin for 24 h and apopt ...	2005	16235987
growth inhibitory activities of crude extracts obtained from herbal plants in the ryukyu islands on several human colon carcinoma cell lines.	there is increasing interest in the use of herbs for the treatment of human diseases including cancer. therefore, the purpose of this study was to determine whether crude extracts obtained from 44 herbal plants in the ryukyu islands might contain components capable of inhibiting the growth of a variety of human colon carcinoma cell lines. leaves, roots and other parts of the plants were extracted with chloroform, and the crude extracts were dissolved in dimethylsulfoxide and used for the experim ...	2005	16235999
inhibition of lipid peroxidation and protein oxidation in rat liver mitochondria by curcumin and its analogues.	curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, 1) is a yellow ingredient isolated from turmeric (curcumin longa). it has been shown to exhibit a variety of biological activities including antioxidative activity. in order to find more active antioxidants with 1 as the lead compound we synthesized curcumin analogues, i.e., 1-(3,4-dihydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione (2), 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5- ...	2006	16236451
immunomodulatory effects of curcumin.	curcumin (diferuloylmethane), found in the spice turmeric, exhibits anti-inflammatory, antioxidant, and chemopreventive activities. however, the effect of curcumin on the immunological responses largely remains unknown. in this study we have investigated the effect of curcumin on mitogen (phytohaemagglutinin; pha) stimulated t-cell proliferation, natural killer (nk) cell cytotoxicity, production of cytokines by human peripheral blood mononuclear cells (pbmcs), nitric oxide (no) production in mou ...	2005	16237958
curcumin inhibits platelet-derived growth factor-stimulated vascular smooth muscle cell function and injury-induced neointima formation.	vascular smooth muscle cell (vsmc) migration, proliferation, and collagen synthesis are key events involved in the pathogenesis of cardiovascular disease. growth factors, such as platelet-derived growth factor (pdgf) and fibroblast growth factor, released during vascular injury plays a pivotal role in regulating these events. curcumin (diferuloyl methane), a major component of the spice turmeric (curcuma longa), has been shown recently to have beneficial effects in chronic conditions, such as in ...	2006	16239599
antimicrobial effect of thai spices against listeria monocytogenes and salmonella typhimurium dt104.	the objective of this study was to determine the potential antimicrobial activity of extracts and essential oils of spices from thailand against foodborne pathogenic bacteria. the antimicrobial efficacy of ginger (zingiber officinale), fingerroot (boesenbergia pandurata), and turmeric (curcuma longa) was evaluated against five strains of listeria monocytogenes and four strains of salmonella enterica ssp. enterica serovar typhimurium dt104. antimicrobial activity was investigated in microbiologic ...	2005	16245707
prevention of kainic acid-induced changes in nitric oxide level and neuronal cell damage in the rat hippocampus by manganese complexes of curcumin and diacetylcurcumin.	curcumin is a natural antioxidant isolated from the medicinal plant curcuma longa linn. we previously reported that manganese complexes of curcumin (cp-mn) and diacetylcurcumin (diac-cp-mn) exhibited potent superoxide dismutase (sod)-like activity in an in vitro assay. nitric oxide (no) is a free radial playing a multifaceted role in the brain and its excessive production is known to induce neurotoxicity. here, we examined the in vivo effect of cp-mn and diac-cp-mn on no levels enhanced by kaini ...	2006	16266725
prevention of alzheimer's disease: omega-3 fatty acid and phenolic anti-oxidant interventions.	alzheimer's disease (ad) and cardiovascular disease (cvd) are syndromes of aging that share analogous lesions and risk factors, involving lipoproteins, oxidative damage and inflammation. unlike in cvd, in ad, sensitive biomarkers are unknown, and high-risk groups are understudied. to identify potential prevention strategies in ad, we have focused on pre-clinical models (transgenic and amyloid infusion models), testing dietary/lifestyle factors strongly implicated in reducing risk in epidemiologi ...	2005	16266772
comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity.	essential oils extracted from different plants (anthemis nobilis l., artemisia dracunculus l., cannabis sativa l., cupressus sempervirens l., cymbopogon citratus (dc.) stapf., curcuma longa l., foeniculum vulgare l., hypericum perforatum l., hyssopus officinalis l., mentha spicata l., monarda didyma l., ocimum basilicum l., ocotea quixos kosterm., origanum vulgare l., pinus nigra j.f. arnold, pinus silvestris l., piper crassinervium kunth., rosmarinus officinalis l., salvia officinalis l., salvi ...	2006	16274702
curcuma longa l. constituents inhibit sortase a and staphylococcus aureus cell adhesion to fibronectin.	the inhibitory activity of curcuma longa l. (turmeric) rhizome constituents against sortase a, a bacterial surface protein anchoring transpeptidase, from staphylococcus aureus atcc 6538p was evaluated. the activity of the isolated compounds (1-4) was compared to that of the positive control,p-hydroxymecuribenzoic acid (phmb). the biologically active components of c. longa rhizome were characterized by spectroscopic analysis as the curcuminoids curcumin (1), demethoxycurcumin (2), and bisdemethox ...	2005	16277395
turmeric (curcuma longa) rhizome paste and honey show similar wound healing potential: a preclinical study in rabbits.	the potential efficacy of fresh turmeric (curcuma longa) paste to heal wounds was tested in a preclinical study in an animal model. turmeric paste was compared with honey as a topical medicament against a control on experimentally created full-thickness circular wounds in 18 rabbits (oryctolagous cuniculus). wound healing was assessed on the basis of physical, histomorphological, and histochemical parameters on treatment days 0, 3, 7, and 14. only tensile strength was measured on day 14 of treat ...	2005	16286372
selective protection of curcumin against carbon tetrachloride-induced inactivation of hepatic cytochrome p450 isozymes in rats.	we investigated the effects of curcumin, a major antioxidant constituent of turmeric, on hepatic cytochrome p450 (cyp) activity in rats. wistar rats received curcumin-containing diets (0.05, 0.5 and 5 g/kg diet) with or without injection of carbon tetrachloride (ccl(4)). the hepatic cyp content and activities of six cyp isozymes remained unchanged by curcumin treatment, except for the group treated with the extremely high dose (5 g/kg). this suggested that daily dose of curcumin does not cause c ...	2006	16288784
curcumin modulates drug metabolizing enzymes in the female swiss webster mouse.	curcumin, the yellow pigment found in turmeric, exhibits potent chemopreventative properties in both in vivo and in vitro cancer models. we hypothesized that this effect may occur via curcumin-mediated changes in enzymes involved in both carcinogen bioactivation and estrogen metabolism. female swiss webster mice were treated with either curcumin (200 mg/kg or 400 mg/kg, p.o.) or vehicle control for 1 or 2 weeks. the results demonstrated that curcumin had no effect on the catalytic activities of ...	2006	16297412
curcumin induces human ht-29 colon adenocarcinoma cell apoptosis by activating p53 and regulating apoptosis-related protein expression.	curcumin, a major yellow pigment and active component of turmeric, has multiple anti-cancer properties. however, its molecular targets and mechanisms of action on human colon adenocarcinoma cells are unknown. in the present study, we examined the effects of curcumin on the proliferation of human colon adenocarcinoma ht-29 cells by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide method and confirmed the curcumin-induced apoptosis by morphology and dna ladder formation. at the sam ...	2005	16302093
in vitro susceptibility of helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders.	the gram-negative bacterium helicobacter pylori (hp), identified in 1982, is now recognized as the primary etiological factor associated with the development of gastritis and peptic ulcer disease. in addition, hp infections are also associated with chronic gastritis, gastric carcinoma and primary gastric b-cell lymphoma. for centuries, herbals have been used in traditional medicine to treat a wide range of ailments, including gastrointestinal (gi) disorders such as dyspepsia, gastritis and pepti ...	2005	16317658
curcuma longa extract protects against gastric ulcers by blocking h2 histamine receptors.	curcuma longa has been commonly used as a traditional remedy for a variety of symptoms such as inflammation, gastritis and gastric ulcer. when c. longa extract was administered per os to pylori-ligated rat stomachs, it reduced gastric acid secretion and protected against the formation of gastric mucosal lesions. we therefore tested whether c. longa extract inhibits gastric ulcers by blocking the h(2) histamine receptor. dimaprit, a h(2) histamine receptor agonist, induced intracellular camp prod ...	2005	16327153
synergistic inhibitory effects of curcumin and 5-fluorouracil on the growth of the human colon cancer cell line ht-29.	the synergistic effect of combination treatment with cox-2 inhibitors and chemotherapy may be another promising therapy regimen in the future treatment of colorectal cancer. curcumin, a major yellow pigment in turmeric which is used widely all over the world, inhibits the growth of human colon cancer cell line ht-29 significantly and specifically inhibits the expression of cox-2 protein. however, the worldwide exposure of populations to curcumin raised the question of whether this agent would en ...	2006	16340194
the influence of curcumin and manganese complex of curcumin on cadmium-induced oxidative damage and trace elements status in tissues of mice.	curcumin (diferuoyl methane) from turmeric is a well-known biologically active compound. it has been shown to ameliorate oxidative stress and it is considered to be a potent cancer chemopreventive agent. in our previous study the antioxidative effects of curcumin in cadmium exposed animals were demonstrated. also manganese exerts protective effects in experimental cadmium intoxication. the present study examined the ability of the manganese complex of curcumin (mn-curcumin) and curcumin to prote ...	2006	16345010
plant foods in the management of diabetes mellitus: spices as beneficial antidiabetic food adjuncts.	diet has been recognized as a corner stone in the management of diabetes mellitus. spices are the common dietary adjuncts that contribute to the taste and flavour of foods. besides, spices are also known to exert several beneficial physiological effects including the antidiabetic influence. this review considers all the available information from animal experimentation as well as clinical trials where spices, their extracts or their active principles were examined for treatment of diabetes. amon ...	2005	16361181
curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active jak-stat pathway in t cell leukemia.	adult t cell leukemia is an aggressive and frequently fatal malignancy that expressess constitutively activated growth-signaling pathways in association with deregulated growth and resistance to apoptosis. curcumin (diferuloylmethane) is a naturally occurring yellow pigment, isolated from the rhizomes of the plant curcuma longa that has traditionally been used in the treatment of injury and inflammation. but the effect and mechanism of action of curcumin on t cell leukemia is not known. to inves ...	2006	16364242
a comparison of the antimicrobial activity of garlic, ginger, carrot, and turmeric pastes against escherichia coli o157:h7 in laboratory buffer and ground beef.	the antimicrobial effects of garlic, ginger, carrot and turmeric pastes against escherichia coli o157:h7 in laboratory buffer and model food system were investigated. turmeric paste, fresh carrot, ginger and garlic pastes from roots, and commercial ginger and garlic paste were heated alone or with buffered peptone water (bpw) or ground beef at 70 degrees c for 7 min. all samples were inoculated with a three strain cocktail of overnight cultures of e. coli o157: h7 and stored at 4 degrees c and 8 ...	2005	16366855
antiproliferation and apoptosis induced by curcumin in human ovarian cancer cells.	curcumin, an active ingredient from the rhizome of the plant, curcuma longa, has antioxidant, anti-inflammatory and anti-cancer activities. it has recently been demonstrated that the chemopreventive activities of curcumin might be due to its ability to inhibit cell growth and induce apoptosis. in the present study, we have investigated the effects of curcumin on growth and apoptosis in the human ovarian cancer cell line ho-8910 by mtt assay, fluorescence microscopy, flow cytometry and western bl ...	2006	16376585
alpha-glucosidase inhibition of natural curcuminoids and curcumin analogs.	natural curcumin (1), demethoxycurcumin (2) and bisdemethoxycurcumin (3) isolated from curcuma longa (turmeric), and synthetic curcumin analogs (a(1-7), b(1-7), c(1-6) and d(1-7)) were evaluated in vitro for the alpha-glucosidase inhibitory activity via uv and circular dichroism (cd) spectroscopy. the results indicated that natural curcuminoid compound 3 showed a remarkable inhibitory effect with ic(50) of 23.0 microm, and the synthetic compounds a(2), b(2), c(2) and d(2) showed potent inhibitor ...	2006	16387392
curcumin inhibits the classical and the alternate pathways of complement activation.	curcumin (cur), the golden yellow phenolic compound in turmeric, is well studied for its medicinal properties. in the current investigation, cur dissolved using sodium hydroxide solution (curna) was tested for in vitro complement inhibitory activity and compared with rosmarinic acid (ra) and quercetin (qur) dissolved using sodium hydroxide (rana and qurna, respectively) and the vaccinia virus complement control protein (vcp). the comparative study indicated that curna inhibited the classical com ...	2005	16387680
curcumin: getting back to the roots.	the use of turmeric, derived from the root of the plant curcuma longa, for treatment of different inflammatory diseases has been described in ayurveda and in traditional chinese medicine for thousands of years. the active component of turmeric responsible for this activity, curcumin, was identified almost two centuries ago. modern science has revealed that curcumin mediates its effects by modulation of several important molecular targets, including transcription factors (e.g., nf-kappab, ap-1, e ...	2005	16387689
curcumin, an atoxic antioxidant and natural nfkappab, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases.	the world suffers a tsunami of chronic diseases, and a typhoon of acute illnesses, many of which are associated with the inappropriate or exaggerated activation of genes involved in inflammation. finding therapeutic agents which can modulate the inflammatory reaction is the highest priority in medical research today. drugs developed by the pharmaceutical industry have thus far been associated with toxicity and side effects, which is why natural substances are of increasing interest.	2013	16387899
a pilot study of the antioxidant effect of curcumin in tropical pancreatitis.	oxidative stress occurs in association with painful exacerbations of chronic pancreatitis and antioxidant supplementation appears to benefit this condition. curcumin, the active constituent of turmeric, is known to exhibit antioxidant activity. this pilot study was therefore undertaken to evaluate the effect of oral curcumin with piperine on the pain, and the markers of oxidative stress in patients with tropical pancreatitis (tp).	2005	16394323
an efficient protocol for genetic transformation and shoot regeneration of turmeric (curcuma longa l.) via particle bombardment.	turmeric (curcuma longa l.) is an important spice crop plant that is sterile and cannot be improved by conventional breeding. an efficient method for stable transformation for turmeric, c. longa l., was developed using particle bombardment. callus cultures initiated from shoots were bombarded with gold particles coated with plasmid pahc25 containing the bar and gusa genes each driven by the maize ubiquitin promoter. transformants were selected on medium containing glufosinate. transgenic lines w ...	2006	16397786
inhibitory effect of thai plant extracts on p-glycoprotein mediated efflux.	curcuminoids from curcuma longa l. and extracts of psidium guajava l., andrographis paniculata (burm. f.) nees, phyllanthus emblica l. and solanum trilobatum l. were investigated for their inhibitory effect on p-glycoprotein (p-gp) on the efflux transport of rhodamine 123 (rho-123 ) in caco-2 cells and rat ileum. of the five tested samples, curcuminoids and an extract of p. guajava showed the highest inhibitory effect on p-gp mediated efflux of rho-123 in caco-2 cells. additionally, they were fo ...	2006	16397849
opposing action of curcumin and green tea polyphenol in human keratinocytes.	persistent environmental insult can convert a normal cell into a cancer cell. however, various natural chemopreventive agents called antioxidants can retard this progression. we have recently explored the effects of several chemopreventive agents, including green tea polyphenol and curcumin, on normal human keratinocyte function. our findings suggest that a bioactive polyphenol from green tea, (-)-epigallocatechin-3-gallate (egcg), acts to increase involucrin gene expression, suggesting that egc ...	2006	16404707
multiple biological activities of curcumin: a short review.	turmeric (curcuma longa rhizomes), commonly used as a spice is well documented for its medicinal properties in indian and chinese systems of medicine. it has been widely used for the treatment of several diseases. epidemiological observations, though inconclusive, are suggestive that turmeric consumption may reduce the risk of some form of cancers and render other protective biological effects in humans. these biological effects of turmeric have been attributed to its constituent curcumin that h ...	2006	16413584
curcumin differentially sensitizes malignant glioma cells to trail/apo2l-mediated apoptosis through activation of procaspases and release of cytochrome c from mitochondria.	malignant glioma cells are generally resistant or only weakly sensitive to tumor necrosis factor family of cell death-inducing ligands, including tnf-related apoptosis-inducing ligand (trail)/apo2l. the chemopreventive activity of polyphenolic compounds present in plant-derived food products has been well recognized in epidemiological studies; however, the mechanism of chemoprevention by these dietary constituents largely remains unknown. curcumin, the yellow pigment in the spice turmeric, has p ...	2005	16416600
protection by turmeric and myrrh against liver oxidative damage and genotoxicity induced by lead acetate in mice.	the effects of lead acetate in the diet (0.5% w/w) on reduced gsh, activity of phase ii metabolizing enzyme glutathione s-transferase (gst), lipid peroxidation in liver homogenate and bone marrow chromosomes of mice simultaneously supplemented with powdered turmeric and myrrh for 8 weeks were investigated. five groups of swiss male albino mice, each of 30 mice, the first group received a basal diet and served as negative control, the second group received basal diet supplemented with lead acetat ...	2006	16433888
suppressive effects of okinawan food items on free radical generation from stimulated leukocytes and identification of some active constituents: implications for the prevention of inflammation-associated carcinogenesis.	okinawa prefecture in japan is a distinct area characterized by unique traditional food habits and longevity. prolonged exposure to activated leukocytes, playing pivotal roles in chronic inflammation-associated carcinogenesis, is known to lead to oxidative and nitrosative damage to macromolecules in the body since they are primary sources of free radicals, such as superoxide anion (o(2)(-)) and nitric oxide (no). in this study, we estimated anti-oxidative and anti-nitrosative activities of okina ...	2005	16435988
bactericidal and anti-adhesive properties of culinary and medicinal plants against helicobacter pylori.	to investigate the bactericidal and anti-adhesive properties of 25 plants against helicobacter pylori (h. pylori).	2005	16437723
menopause: a review on the role of oxygen stress and favorable effects of dietary antioxidants.	menopause is often accompanied by hot flashes and degenerative processes such as arteriosclerosis and atrophic changes of the skin that suggest an acceleration of aging triggered by estrogen lack. therefore, hormone replacement therapy (hrt) has been considered the most suitable treatment for the above symptoms and processes. however, because of the possible serious side effects of hrt (especially the increased risk of thrombo-embolic accidents and breast cancer) there is a growing demand for al ...	2013	16442644