Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| phase i clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. | curcumin (diferuloylmethane), a yellow substance from the root of the plant curcuma longa linn., has been demonstrated to inhibit carcinogenesis of murine skin, stomach, intestine and liver. however, the toxicology, pharmacokinetics and biologically effective dose of curcumin in humans have not been reported. this prospective phase-i study evaluated these issues of curcumin in patients with one of the following five high-risk conditions: 1) recently resected urinary bladder cancer; 2) arsenic bo ... | 2013 | 11712783 |
| inhibitory effects of naturally occurring compounds on aflatoxin b(1) biotransformation. | effects of naturally occurring compounds from plants on biotransformation of a mycotoxin, aflatoxin b(1), were evaluated. among 77 naturally occurring compounds tested, anthraquinones, coumarins, and flavone-type flavonoids were shown to be potent inhibitors of aflatoxin b(1)-8,9-epoxide formation. addition of the flavonoids galangin, rhamnetin, and flavone strongly inhibited mouse liver microsomal conversion of aflatoxin b(1) to aflatoxin b(1)-8,9-epoxide, a metabolically activated mutagenic pr ... | 2001 | 11714299 |
| mechanism(s) of turmeric-mediated protective effects against benzo(a)pyrene-derived dna adducts. | the effects of turmeric feeding before and after benzo(a)pyrene [b(a)p] exposure on the levels of b(a)p-derived dna adducts were studied in tissues of swiss mice employing (32)p-postlabelling analysis. a reduction in the levels of b(a)p-derived dna adducts in liver, lung, and forestomach was observed in animals pre-treated with 0.2 or 1% turmeric diet and exposed to b(a)p by oral intubation when compared to animals receiving standard laboratory diet and b(a)p. the observed decrease was not due t ... | 2002 | 11734339 |
| diarylheptanoids with free radical scavenging and hepatoprotective activity in vitro from curcuma longa. | assay-guided fractionation of the etoac soluble fraction of the rhizomes of curcuma longa furnished three dpph free radical scavenging diarylheptanoids, curcumin (1), demethoxycurcumin (2), and bisdemethoxycurcumin (3). compounds 1-3 showed the dpph radical scavenging effects with ic(50) values of 2.8, 39.2, 308.7 microm, respectively. l-ascorbic acid and resveratrol as positive controls exhibited ic(50) values of 22.5 and 25.0 microm, respectively. compounds 1-3 showed significant hepatoprotect ... | 2001 | 11745031 |
| evaluation of ophthacare eye drops--a herbal formulation in the management of various ophthalmic disorders. | an open prospective multicentre clinical trial was conducted in patients suffering from various ophthalmic disorders namely, conjunctivitis, conjunctival xerosis (dry eye), acute dacryocystitis, degenerative conditions (pterygium or pinguecula) and postoperative cataract patients with a herbal eye drop preparation (ophthacare) containing basic principles of different herbs which have been conventionally used in the ayurvedic system of medicine since time immemorial. these include carum copticum, ... | 2001 | 11746845 |
| curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, bid cleavage and cytochrome c release: its suppression by ectopic expression of bcl-2 and bcl-xl. | pharmacologically safe compounds that can inhibit the proliferation of tumor cells have potential as anticancer agents. curcumin, a diferuloylmethane, is a major active component of the food flavor turmeric (curcuma longa) that has been shown to inhibit the proliferation of a wide variety of tumor cells. the apoptotic intermediates through which curcumin exhibits its cytotoxic effects against tumor cells are not known, and the participation of antiapoptotic proteins bcl-2 or bcl-xl in the curcum ... | 2002 | 11756235 |
| non-destructive nir-ft-raman analyses in practice. part i. analyses of plants and historic textiles. | non-destructive analysis of natural substances in plants as well as of old dyed textiles by raman spectroscopy has not been possible using conventional techniques. exciting lines from the visible part of the spectrum produced photochemical and thermal decomposition of the objects as well as strong fluorescence. using nd:yag laser excitation at 1,064 nm together with a special sample arrangement and interferometric recording, various polyacetylenes in aethusa cynapium and in chamomile (chamomilla ... | 2001 | 11769790 |
| induction of stress response renders human tumor cell lines resistant to curcumin-mediated apoptosis: role of reactive oxygen intermediates. | curcumin, a well-known dietary pigment derived from curcuma longa, has been shown to be a potent antiinflammatory, antioxidant, and anticarcinogenic compound. the present study was designed to investigate the cytotoxic potential of curcumin against a range of human tumor cell lines in an attempt to understand its mechanism of action, which may lead to its possible therapeutic applications. we have shown that different cancer cell lines differ in their sensitivity to curcumin. cell lines establis ... | 2001 | 11795474 |
| metabolism of the cancer chemopreventive agent curcumin in human and rat intestine. | curcumin, the yellow pigment in turmeric, prevents malignancies in the intestinal tract of rodents. it is under clinical evaluation as a potential colon cancer chemopreventive agent. the systemic bioavailability of curcumin is low, perhaps attributable, at least in part, to metabolism. indirect evidence suggests that curcumin is metabolized in the intestinal tract. to investigate this notion further, we explored curcumin metabolism in subcellular fractions of human and rat intestinal tissue, com ... | 2002 | 11815407 |
| efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats. | in the traditional system of medicine, ayurveda, several spices and herbs are thought to possess medicinal properties. among the spices, turmeric rhizomes (curcuma longa. linn.) are used as flavoring and coloring agents in the indian diet everyday. in this research, we studied the effect of turmeric and its active principle, curcumin, on diabetes mellitus in a rat model. alloxan was used to induce diabetes. administration of turmeric or curcumin to diabetic rats reduced the blood sugar, hb and g ... | 2002 | 11855620 |
| inhibitory effect of herbal remedies on 12-o-tetradecanoylphorbol-13-acetate-promoted epstein-barr virus early antigen activation. | for the past several years we have been evaluating natural products as potential cancer chemopreventive agents in a short term in vitro assay involving epstein--barr virus early antigen (ebv-ea) activation in raji cells promoted by phorbol ester, 12-o-tetradecanoylphorbol-13-acetate (tpa). because of the current interest in the use of herbal remedies, we considered examining them for their cancer chemopreventive activities, using their extracts with a view to uncovering such benefits (if any) th ... | 2002 | 11884218 |
| cancer chemoprevention by dietary constituents: a tale of failure and promise. | although the results of clinical intervention trials of beta-carotene to prevent lung cancer, and of dietary augmentation with fibre or fruit and vegetables to reduce the occurrence of colonic polyps have so far been negative, a structured path for the development of diet-derived constituents as cancer chemopreventive agents is emerging. putative agents are identified on the basis of epidemiological and preclinical mechanistic studies. some examples of promising diet-derived chemopreventive agen ... | 2001 | 11905754 |
| antimutagenic potential of curcumin on chromosomal aberrations in wistar rats. | curcumin, a yellow pigment commonly used as a spice and food coloring agent is obtained from rhizomes of curcuma longa and is a major chemopreventive component of turmeric. in the present set of investigations the antimutagenic potential of curcumin has been evaluated using in vivo chromosomal aberration assay in wistar rats. cyclophosphamide (cp), a well-known mutagen was given by intraperitoneal (i.p.) injection at the dose of 40 mg/kg body weight (b.w.). curcumin was given at the dose of 100 ... | 2002 | 11909768 |
| latent activity of curcumin against leishmaniasis in vitro. | in this study the anti-proliferative effect of curcumin (curcuma longa) that is the active ingredient of ground dried rhizome has been studied against three local and three reference leishmanial strains, leishmania major, leishmania tropica and leishmania infantum (pakistani isolate). curcumin has shown an average ic50 of 5.3 microm against promastigotes of various leishmanial strains which is much lower as compared with pentamidine that is one of the basic treatments against leishmaniasis. the ... | 2002 | 11913540 |
| nutrition and ageing. | the reviewed literature indicates that, even in industrialised countries, the nutrition of mature and aged subjects is often inadequate (because of deficiency or excess), which may lead to premature or pathological senescence. recent nutritional research on ageing laboratory animals shows that dietary restriction may be the most effective procedure to achieve a long and disease-free life span, probably owing to a better protection against mitochondria-linked oxygen stress. likewise, the experime ... | 2001 | 11918486 |
| effect of curcumin on ethanol-induced stress on mononuclear cells. | blood cells in circulation are exposed to a wide variety of stress-causing agents, causing a number of changes including interactions with other cells and the extracellular matrix of the endothelial wall. in order to understand the role of curcumin, an antioxidant principle from curcuma longa linn., on blood mononuclear cells from rabbits given ethanol for 30 days and ethanol with curcumin, cells were isolated and an attachment assay was carried out. the monocytes from ethanol-treated rabbits sh ... | 2002 | 11933122 |
| [determination of chemical constituents of the volatile oil from curcuma longa by gas chromatography-mass spectrometry]. | the study of chemical constituents of the volatile oil from curcuma longa is reported. the volatile oil was extracted by steam distillation. fifteen components in the oil were separated and identified by gas chromatography-mass spectrometry(gc/ms). the results were elucidated based on the nbs standard mass spectral data. the total ion current chromatogram showed their mass fraction by normalization method. alpha-curcumene, alpha-zingiberene, 1,8-cineole and zerumbone, which had been reported bef ... | 1998 | 11938917 |
| bioactivities of the leaf essential oil of curcuma longa (var. ch-66) on three species of stored-product beetles (coleoptera). | essential oil extracted from the leaves of turmeric, curcuma longa l., was investigated for contact and fumigant toxicity and its effect on progeny production in three stored-product beetles, rhyzopertha dominica f. (lesser grain borer), sitophilus oryzae l. (rice weevil), and tribolium castaneum herbst (red flour beetle). oviposition-deterrent and ovicidal actions of c. longa leaf oil were also evaluated against t. castaneum. the oil was insecticidal in both contact and fumigant toxicity assays ... | 2002 | 11942755 |
| selective induction of apoptosis by ar-turmerone isolated from turmeric (curcuma longa l) in two human leukemia cell lines, but not in human stomach cancer cell line. | we have investigated the effects of ar-turmerone isolated from turmeric (curcuma longa l) on dna of human leukemia cell lines, molt 4b, hl-60 and stomach cancer kato iii cells. it was found that selective induction of apoptosis by ar-turmerone was observed in human leukemia molt 4b and hl-60 cells, but not in human stomach cancer kato iii cells. morphological changes showing apoptotic bodies were observed in the human hl-60 and molt 4b cells treated with ar-turmerone. the fragmentation of dna by ... | 2002 | 11956652 |
| structural identification of new curcumin dimers and their contribution to the antioxidant mechanism of curcumin. | as a part of the research project on the elucidation of the chain-breaking antioxidant mechanism of natural phenolics against the oxidation of food components, curcumin, a main turmeric pigment, was investigated. a relatively high concentration of curcumin gave three dimers as radical termination products in addition to the coupling products with curcumin and the lipid hydroperoxide. the structural analysis of these dimers and quantitative analysis of their production rates revealed that radical ... | 2002 | 11958616 |
| survey of residual solvents in natural food additives by standard addition head-space gc. | residual levels of 12 solvents in 87 natural food additives (66 samples of food colours, 19 samples of natural antioxidants and two natural preservatives) collected between 1997 and 1999 were determined by automated head-space gc using fid, with a porous-polymer (plot) column. calibration curves were prepared by the method of standard addition. confirmation was by manually injected head-space gc using mass spectrometric detection. 1,2-dichloroethane was found in turmeric colour (natural food col ... | 2002 | 11962690 |
| curcumin: a new cell-permeant inhibitor of the inositol 1,4,5-trisphosphate receptor. | curcumin (diferuoylmethane or 1,7-bis (4-hydroxy-3-methoxyphenol)-1,6-hepatadiene-3,5-dione) is the active ingredient of the spice turmeric. curcumin has been shown to have a number of pharmacological and therapeutic uses. this study shows that curcumin is a potent inhibitor of the inositol 1,4,5-trisphosphate-sensitive ca2+ channel (insp3 receptor). in porcine cerebellar microsomes, the extent of insp3-induced ca2+ release (iicr) is almost completely inhibited by 50 microm curcumin (ic50 = 10 m ... | 2002 | 11990299 |
| [effect of d-limonene, salvia miltiorrhiza and turmeric derivatives on membrane association of ras gene product and gap junction intercellular communication]. | gap junction intercellular communication (gjic), h-ras oncogene expression and ras oncogene product(p21ras protein) expression were studied in four human solid tumor cell lines, w1-38, caco2, a549 and paca (with the different ras gene mutation rate), and the effects of four compounds, salvia miltiorrhiza derivative (smd), d-limonene, turmeric derivative i(td-i) and turmeric derivative ii(td-ii), on them. the abilities of the four solid tumor cell lines to transfer dye to adjacent cells were exam ... | 1998 | 12016941 |
| chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis. | curcumin, the major yellow pigment in turmeric, prevents the development of adenomas in the intestinal tract of the c57bl/6j min/+ mouse, a model of human familial apc. to aid the rational development of curcumin as a colorectal cancer-preventive agent, we explored the link between its chemopreventive potency in the min/+ mouse and levels of drug and metabolites in target tissue and plasma. mice received dietary curcumin for 15 weeks, after which adenomas were enumerated. levels of curcumin and ... | 2002 | 12050094 |
| curcumin inhibits experimental allergic encephalomyelitis by blocking il-12 signaling through janus kinase-stat pathway in t lymphocytes. | experimental allergic encephalomyelitis (eae) is a cd4(+) th1 cell-mediated inflammatory demyelinating autoimmune disease of the cns that serves as an animal model for multiple sclerosis (ms). il-12 is a proinflammatory cytokine that plays a crucial role in the induction of neural ag-specific th1 differentiation and pathogenesis of cns demyelination in eae and ms. curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) is a naturally occurring polyphenolic phytochemical isolated f ... | 2002 | 12055272 |
| improved hplc method for the determination of curcumin, demethoxycurcumin, and bisdemethoxycurcumin. | commercially available curcumin, a bright orange-yellow color pigment of turmeric, consists of a mixture of three curcuminoids, namely, curcumin, demethoxycurcumin, and bisdemethoxycurcumin. these were isolated by column chromatography and identified by spectroscopic studies. the purity of the curcuminoids was analyzed by an improved hplc method. hplc separation was performed on a c(18) column using three solvents, methanol, 2% acoh, and acetonitrile, with detection at 425 nm. four different com ... | 2002 | 12059141 |
| radioprotective action of curcumin extracted from curcuma longa linn: inhibitory effect on formation of urinary 8-hydroxy-2'-deoxyguanosine, tumorigenesis, but not mortality, induced by gamma-ray irradiation. | we evaluated the radioprotective action of curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] extracted from curcuma longa linn against the acute and chronic effects and the mortality induced by exposure to radiation using female rats. | 2002 | 12062620 |
| [wound management with coconut oil in indonesian folk medicine]. | the medical plants which are used to treat wounds and injuries by the ethnic group of ngada on flores, an eastern indonesian island, will be presented. additionally, the coconut oil used to treat wounds and to conserve medicinal plants will be analysed biochemically. the people of ngada use the following plants for wound treatment: seeds of the betel nut (areca catechu l.), fruits of papaya (carica papaya l.), leaves of the indian hydrocotyle (centelle asiatica l.), the rhizome of turmeric (curc ... | 2002 | 12063927 |
| anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review. | a wide variety of phenolic substances derived from spice possess potent antimutagenic and anticarcinogenic activities. examples are curcumin, a yellow colouring agent, contained in turmeric (curcuma longa l., zingiberaceae), [6]-gingerol, a pungent ingredient present in ginger (zingiber officinale roscoe, zingiberaceae) and capsaicin, a principal pungent principle of hot chili pepper (capsicum annuum l, solanaceae). the chemopreventive effects exerted by these phytochemicals are often associated ... | 2002 | 12067569 |
| curcumin (diferuloylmethane), a singlet oxygen ((1)o(2)) quencher. | curcumin (diferuloylmethane) is a major component of food flavoring turmeric (curcuma longa), and has been reported to be anticarcinogenic and anti-inflammatory. although curcumin was shown to have antioxidant properties, its exact antioxidant nature has not been fully investigated. in this report we have investigated the possible antioxidant properties of curcumin using epr spectroscopic techniques. curcumin was found to inhibit the (1)o(2)-dependent 2,2,6,6-tetramethylpiperidine n-oxyl (tempo) ... | 2002 | 12083767 |
| dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer. | curcumin, the major component of the spice turmeric, is used as a coloring and flavoring additive in many foods and has attracted interest because of its anti-inflammatory and chemopreventive activities. however, this agent also inhibits the generation of reactive oxygen species (ros) and the c-jun nh(2)-terminal kinase (jnk) pathway, and because many chemotherapeutic drugs generate ros and activate jnk in the course of inducing apoptosis, we considered the possibility that curcumin might antago ... | 2002 | 12097302 |
| curcumin inhibits telomerase activity through human telomerase reverse transcritpase in mcf-7 breast cancer cell line. | the inhibitory effect of curcumin, the yellow-colored pigment from turmeric, on telomerase activity was analyzed in human mammary epithelial (mcf-10a) and breast cancer (mcf-7) cells. telomerase activity in mcf-7 cells is 6.9-fold higher than that of human mammary epithelial cells. in mcf-7 cells, telomerase activity decreased with increasing concentrations of curcumin, inhibiting about 93.4% activity at 100 microm concentration. the inhibition of telomerase activity in mcf-7 cells may be due to ... | 2002 | 12104041 |
| new and known symmetrical curcumin derivatives inhibit the formation of fos-jun-dna complex. | we previously reported that curcumin, the yellow pigment of turmeric, inhibited the formation of the fos-jun-dna complex. thus, we have synthesized 12 symmetrical curcuminoids. we used a slightly modified version of pabon's method to search for an inhibitor more potent than curcumin. of the synthesized curcuminoids, bjc005, chc011, and chc007 exhibited a remarkably high inhibitory activity. their ic(50) values are 5.4 microm, 0.30 mm, and 0.38 mm, respectively. these ic(50) data indicated that b ... | 2002 | 12104052 |
| interleukin-1 beta-mediated suppression of rxr:rar transactivation of the ntcp promoter is jnk-dependent. | bile flow is rapidly and markedly reduced in hepatic inflammation, correlating with suppression of critical hepatic bile acid transporter gene expression, including the principal hepatic bile acid importer, the na(+)/taurocholate co-transporting polypeptide (ntcp, slc10a1). endotoxin treatment of rats and interleukin-1 beta (il-1 beta) treatment of liver-derived hepg2 cells leads to a marked decline in the nuclear binding activity of a main ntcp gene regulator, the nuclear receptor heterodimer r ... | 2002 | 12105223 |
| curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits. | this study evaluates the effect of a curcuma longa extract on the development of experimental atherosclerosis (fatty streak) in rabbits and its interaction with other plasmatic antioxidants. | 2002 | 12117742 |
| inhibition of 7,12-dimethylbenz[a]anthracene (dmba)-induced oral carcinogenesis in hamsters by tea and curcumin. | tea is one of the most popular beverages consumed in the world. curcumin, the major yellow pigment in turmeric, is used widely as a spice and food-coloring agent. in this study, we studied the effects of tea and curcumin on 7,12-dimethylbenz[a]anthracene (dmba)-induced oral carcinogenesis in hamsters. dmba solution (0.5% in mineral oil, 0.1 ml) was applied topically to the left cheek pouch of male syrian golden hamsters 3 times/week for 6 weeks. two days after the last treatment of dmba, the ani ... | 2002 | 12151348 |
| chemotherapeutic potential of curcumin for colorectal cancer. | colorectal cancer is one of the leading causes of cancer deaths in the western world. more than 56,000 newly diagnosed colorectal cancer patients die each year in the united states. available therapies are either not effective or have unwanted side effects. epidemiological data suggest that dietary manipulations play an important role in the prevention of many human cancers. curcumin the yellow pigment in turmeric has been widely used for centuries in the asian countries without any toxic effect ... | 2002 | 12171541 |
| survey of arsenic in food composites from an arsenic-affected area of west bengal, india. | an investigation of total arsenic in food composites, collected from the villagers, was carried out in arsenic-affected areas of the murshidabad district, west bengal where the agricultural system is mostly groundwater dependent. the shallow, large-diameter tubewells installed for agricultural irrigation contain an appreciable amount of arsenic (mean 0.085 mg/l, n=6). even the soil is arsenic-contaminated (mean 11.35 mg/kg, n=36), so some arsenic can be expected in the food chain from crops cult ... | 2002 | 12176088 |
| capillary electrophoresis with amperometric detection of curcumin in chinese herbal medicine pretreated by solid-phase extraction. | in the present study, curcumin from chinese herbal medicine turmeric was determined by capillary electrophoresis with amperometric detection (ce-ad) pretreated by a self-designed, simple, inexpensive solid-phase extraction (spe) cartridge based on the material of tributyl phosphate resin. an average concentration factor of 9 with the recovery of > 80% was achieved when applied to the analysis of curcumin in extracts of tumeric. under the optimized ce-ad conditions: a running buffer composed of 1 ... | 2002 | 12198956 |
| [effects of cultivating measures on rhizome yield and some main active constituents of curcuma longa l]. | to substantiate the effects of cultivating measures on the rhizome yield and main active constituents of curcuma longa. | 1999 | 12205897 |
| [effect of growth period, storage time and varieties on the contents of main active constituents of curcuma longa l. in rhizome]. | to provide criteria for selection, storage and cultivation of the rhizome of curcuma longa. | 1999 | 12205954 |
| [a study on soil suitability for growth of rhizome of curcuma longa l]. | to seek for the type of soil that influences favorably the yield and quality of curcuma longa. | 1999 | 12205979 |
| [a study on fresh rhizome simulation model and its application to comprehensive agronomic measures for good quality and high yield of curcuma longa l]. | to work out standardized cultivating measures for curcuma longa according to the analysis of fresh rhizome simulation model. | 1999 | 12212083 |
| curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface:impact on human pancreatic carcinoma cell growth by autocrine regulation. | curcumin, the yellow pigment in turmeric, has been shown to prevent tumor progression in a variety of tissues in rodents. the authors investigated the effect of curcumin on human carcinoma cell lines to determine whether constitutive interleukin-8 (il-8) production of tumor cells was correlated with nuclear factor kappab (nf-kappab) activation and cell growth activity. | 2002 | 12216086 |
| curcumin suppresses activation of nf-kappab and ap-1 induced by phorbol ester in cultured human promyelocytic leukemia cells. | many components that are derived from medicinal or dietary plants possess potential chemopreventive properties. curcumin, a yellow coloring agent from turmeric (curcuma longa linn, zingiberaceae), possesses strong antimutagenic and anticarcinogenic activities. in this study, we have found that curcumin inhibits the 12-o-tetradecanoylphorbol-13-acetate (tpa)-induced nuclear factor kb (nf-kappab) activation by preventing the degradation of the inhibitory protein ikbalpa; and the subsequent translo ... | 2002 | 12297018 |
| discovery of natural products from curcuma longa that protect cells from beta-amyloid insult: a drug discovery effort against alzheimer's disease. | from curcuma longa, two novel compounds, 4' '-(3' "-methoxy-4' "-hydroxyphenyl)-2' '-oxo-3' '-enebutanyl 3-(3'-methoxy-4'hydroxyphenyl)propenoate (calebin-a, 1) and 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one (2), and seven known compounds, 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione (curcumin, 3), 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione (demethoxycurcumin, 4), 1,7-bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione (bisdemethoxycurcumin ... | 2002 | 12350137 |
| molecular mechanisms of anti-angiogenic effect of curcumin. | modulation of pathological angiogenesis by curcumin (diferuloylmethane), the active principle of turmeric, seems to be an important possibility meriting mechanistic investigations. in this report, we have studied the effect of curcumin on the growth of ehrlich ascites tumor cells and endothelial cells in vitro. further, regulation of tumor angiogenesis by modulation of angiogenic ligands and their receptor gene expression in tumor and endothelial cells, respectively, by curcumin was investigated ... | 2002 | 12359244 |
| total synthesis and anti-leishmanial activity of some curcumin analogues. | curcumin (1) an important yellow dye isolated from curcuma longa rhizomes, exhibits a variety of pharmacological effects such as anti-inflammatory, antioxidant and antiviral activity. ten curcuminoids (2-11) were synthesized by the condensation of 2,4-pentanedione with differently substituted benzaldehydes, using the boron complex approach, which avoided knoevenagel condensation at c-3 of the diketone. the curcuminoids were assayed in vitro against leishmania amazonensis promastigotes using pent ... | 2002 | 12404885 |
| the protective effects of tetrahydrocurcumin on oxidative stress in cholesterol-fed rabbits. | tetrahydrocurcumin (thc) is an antioxidative substance which is derived from curcumin by hydrogenation. curcumin is the main component of turmeric and is responsible for the yellow color of curried foods.first, ldl derived from a normal human volunteer was incubated in the presence of an antioxidant with 10 microm cuso(4) at 37 degrees c for 2 hours.all antioxidants tested (thc, curcumin, probucol, and alpha-tocopherol) dose-dependently (1-10 microm) inhibited the oxidative modification of ldl. ... | 2002 | 12409634 |
| nutritional support for chronic myelogenous and other leukemias: a review of the scientific literature. | chronic myelogenous leukemia (cml) is a slowly progressive disease characterized by the overproduction of granulocytes (neutrophils, eosinophils, and basophils). a blood smear shows moderate elevations in white blood cell counts that may persist for years and be benign. platelets are increased in number, although their function is impaired, resulting in symptoms of easy bleeding (purpura, swollen gums). conventional medical treatment is a marrow transplant and alkylating agents, which are usuall ... | 2002 | 12410624 |
| barriers in the management of asthma and attitudes towards complementary medicine. | undertreatment is said to be an important problem for those with asthma. misconceptions regarding the nature and treatment of asthma may contribute to this. this study was planned to evaluate the perception of those with asthma about various aspects of their condition. | 2002 | 12412985 |
| evaluation of natural products on inhibition of inducible cyclooxygenase (cox-2) and nitric oxide synthase (inos) in cultured mouse macrophage cells. | the inhibitors of prostaglandin biosynthesis and nitric oxide production have been considered as potential anti-inflammatory and cancer chemopreventive agents. in this study, we evaluated approximately 170 methanol extracts of natural products including korean herbal medicines for the inhibition of prostaglandin e(2) production (for cox-2 inhibitors) and nitric oxide formation (for inos inhibitors) in lipopolysaccharide (lps)-induced mouse macrophages raw264.7 cells. as a result, several extract ... | 2002 | 12413723 |
| antidepressant activity of aqueous extracts of curcuma longa in mice. | curcuma longa (turmeric) is a well-known indigenous herbal medicine. the aqueous extracts, when administered orally to the mice from 140 to 560 mg/kg for 14 days, were able to elicit dose-dependent relation of immobility reduction in the tail suspension test and the forced swimming test in mice. the effects of the extracts at the dose of 560 mg/kg were more potent than that of reference antidepressant fluoxetine. the extracts, at the dose of 140 mg/kg or above for 14 days, significantly inhibite ... | 2002 | 12413724 |
| evaluation of antioxidant activities and antimutagenicity of turmeric oil: a byproduct from curcumin production. | curcumin removed turmeric oleoresin (crto) was extracted with hexane concentrated to get turmeric oil, and that was fractionated using silica gel column chromatography to obtain three fractions. these fractions were analyzed by gc and gc-ms. turmeric oil contained aromatic turmerone (31.32%), turmerone (15.08%) and curlone (9.7%), whereas fractions iii has aromatic turmerone (44.5%), curlone (19.22%) and turmerone (10.88%) as major compounds also, oxygenated compounds (5,6,8-10) were enriched in ... | 2002 | 12440720 |
| curcumin in plasma and urine: quantitation by high-performance liquid chromatography. | curcumin, a derivative of the plant curcuma longa, is used extensively in the food industry. it is a major component of curry powder, and research has shown that curcumin may prevent cancer and other chronic diseases. we have developed a robust automated analytical method for the determination of curcumin in plasma and urine. the method involves extracting the curcumin from 0.2 ml sample volume with ethyl acetate/methanol organic solvents, and use of an internal standard, beta-17-estradiol aceta ... | 2003 | 12450549 |
| alternative treatment of gallbladder disease. | major risk factors for gallbladder disease include a sedentary lifestyle and a diet rich in refined sugars. in genetically prone individuals, these two factors lead to an abnormal bile composition, altered gut microflora, and hyperinsulinemia, with resulting gallstone formation. as a large percentage of gallbladder patients have continued digestive complaints following cholecystectomy, the author examines complementary and alternative medicine (cam) treatments to counteract gallstone formation. ... | 2003 | 12450782 |
| kinetics of venom and antivenom serum and clinical parameters and treatment efficacy in bothrops alternatus envenomed dogs. | dogs envenomed with non-lethal doses of bothrops alternatus venom received standard antivenom therapy, im injections of flunixin meglumine, or topical treatmentwith aqueous curcuma longa plant extract. biodistribution of the venom and antivenom were determined by elisa. there was no significant difference in the efficacy of antivenom and plant extract on local effects; flunixin treatment had lower efficacy. distribution of the venom was similar with all 3 treatments. serum levels of the antiveno ... | 2002 | 12458635 |
| herbal medication: potential for adverse interactions with analgesic drugs. | the use of herbal supplements in the us has increased dramatically in recent years. these products are not regulated by the food and drug administration (fda) with the same scrutiny as conventional drugs. patients who use herbal supplements often do so in conjunction with conventional drugs. this article is a review of potential adverse interactions between some of the commonly used herbal supplements and analgesic drugs. non-steroidal anti-inflammatory drugs (nsaids), particularly aspirin, have ... | 2002 | 12472978 |
| curcumin induces caspase-3-independent apoptosis in human multidrug-resistant cells. | curcumin, the major component of the spice turmeric, used in 50- micro m concentration, induced cell death in multidrug-resistant cem(p-gp4) and lovo(p-gp4) cells as well as in their sensitive counterparts as assessed by tunel method and morphological observation. in all cells induced to undergo cell death with curcumin, there was no caspase-3 activation because only the unprocessed form of caspase-3 was observed using immunoblotting. | 2002 | 12485871 |
| therapeutic potential of curcumin in human prostate cancer-i. curcumin induces apoptosis in both androgen-dependent and androgen-independent prostate cancer cells. | in an effort to find an alternative nontoxic means of inducing the apoptosis potential in both androgen-dependent and hormone refractory prostate cancer cells, attention was focused on curcumin (turmeric), traditionally used in medicine and cuisine in india and other south-east asian countries. the results indicate that curcumin is a novel and potent inducer of apoptosis in both androgen-dependent and androgen-independent prostate cancer cells. this was accomplished by down-regulating apoptosis ... | 2000 | 12497104 |
| sequence analysis of chinese and japanese curcuma drugs on the 18s rrna gene and trnk gene and the application of amplification-refractory mutation system analysis for their authentication. | the botanical origins of chinese and japanese curcuma drugs were determined to be curcuma longa, c. phaeocaulis, the japanese population of c. zedoaria, c. kwangsiensis, c. wenyujin, and c. aromatica based on a comparison of their 18s rrna gene and trnk gene sequences with those of six curcuma species reported previously. moreover, to develop a more convenient identification method, amplification-refractory mutation system (arms) analysis of both gene regions was performed on plants. the arms me ... | 2002 | 12499646 |
| biodegradable microspheres of curcumin for treatment of inflammation. | curcumin, a natural constituent of curcuma longa (turmeric, cas 458-37-7) was formulated as prolonged release biodegradable microspheres for treatment of inflammation. natural biodegradable polymers, namely, bovine serum albumin and chitosan were used to encapsulate curcumin to form a depot forming drug delivery system. microspheres were prepared by emulsion-solvent evaporation method coupled with chemical cross-linking of the natural polymers. curcumin could be encapsulated into the biodegradab ... | 2002 | 12500496 |
| curcumin differentially regulates tgf-beta1, its receptors and nitric oxide synthase during impaired wound healing. | wound healing is a highly ordered process, requiring complex and coordinated interactions involving peptide growth factors of which transforming growth factor-beta (tgf-beta) is one of the most important. nitric oxide is also an important factor in healing and its production is regulated by inducible nitric oxide synthase (inos). we have earlier shown that curcumin (diferuloylmethane), a natural product obtained from the plant curcuma longa, enhances cutaneous wound healing in normal and diabeti ... | 2002 | 12515914 |
| curcumin (diferuloyl-methane) enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in lncap prostate cancer cells. | the role of natural food products in prevention of prostate cancer has been confirmed in recent epidemiological studies; however, the mechanism of chemoprevention by the dietary constituents largely remains unknown. curcumin, the yellow pigment and active component of turmeric (curcuma longa), exhibits chemopreventive and growth inhibitory activity against several tumor cell lines. the androgen-sensitive human prostate cancer cell line lncap is only slightly susceptible to tumor necrosis factor- ... | 2003 | 12533677 |
| turmeric (curcuma longa) and curcumin inhibit the growth of helicobacter pylori, a group 1 carcinogen. | curcumin, a polyphenolic chemical constituent derived from turmeric (curcuma longa), has been shown to prevent gastric and colon cancers in rodents. many mechanisms have been proposed for the chemopreventative effects, although the effect of curcumin on the growth of helicobacter pylori has not been reported. h. pylori is a group 1 carcinogen and is associated with the development of gastric and colon cancer. | 2002 | 12553052 |
| [technological study on the supercritical-co2 fluid extraction of curcuma longa oils]. | this paper first reports technological study on the extraction of curcuma longa oils by supercritical-co2 fluid, mainly studies the influence of pressure, temperature, flow rate of co2 and time on the yield of the oils, determines optimum technology of extracting the oils, analyzes chemical constituents extracted, compares the oils from sfe-co2 and sd technology, studies industrial test on the sf-co2 extraction. the results shows pressure and temperature are more important factors of influence; ... | 1997 | 12572431 |
| digestive stimulant action of three indian spice mixes in experimental rats. | the present study examined the favourable influence of three spice mixes derived from a few commonly consumed spices of known digestive stimulant action on digestive enzymes of pancreas and small intestine, and on bile secretion and composition in experimental rats. the common ingredients of these mixes were coriander, turmeric, red chilli, black pepper and cumin, while the spice mix ii additionally had ginger, and spice mix iii contained onion. all the three spice mixes favourably enhanced the ... | 2002 | 12577586 |
| [study on the effect of rhizoma curcuma longa on gastrin receptor]. | by the method of receptor combination, effects of the active constituents in rhizoma curcuma longa and radix curcumae were studied. the results showed that rhizoma curcuma longa probably include the excitant or antagonist of gastrin receptor. and the inhibitory intensity was shown as followed: parts of ethyl acetate > parts of methanol > parts of ether > parts of volatile oil, root tuber > rhizome. | 2002 | 12583161 |
| effect of antioxidants (vitamin c, e and turmeric extract) on methimazole induced hypothyroidism in rats. | the study was to investigate the protective effect of antioxidants against methimazole (mmi) induced hypothyroidism in rats. male wistar rats were fed mmi, mmi plus vitamin c, mmi plus vitamin e and mmi plus turmeric extract (te) supplemented diet. at the end of the experiments, thyroid weights, thyroxine (t4), triiodothyronine (t3) and cholesterol levels were determined. it was observed that mmi treated rats showed increase in thyroid weights, very low levels of circulating t4, t3 and increased ... | 2002 | 12587721 |
| inhibition of nitrosodiethylamine-induced hepatocarcinogenesis by dietary turmeric in rats. | turmeric, widely used in food and medicine has been shown to prevent benzo(a)pyrene [b(a)p] or dimethylbenz(a)anthracene (dmba)-induced forestomach, skin and mammary tumors in mice and/or rats. in this study we examine the modulatory effects of turmeric on nitrosodiethylamine (ndea)-induced hepatocarcinogenesis in rats. female wistar rats were administered ndea (200 ppm) through drinking water (5 days per week) for 4 weeks. control and/or ndea-treated rats received 0, 0.2, 1.0 or 5.0% turmeric d ... | 2003 | 12595157 |
| curcumin differentially modulates mrna profiles in jurkat t and human peripheral blood mononuclear cells. | curcumin, the yellow pigment of the rhizome of curcuma longa is known to inhibit the transcription factors ap-1, egr-1, nf-kappab, c-myc and several important signaling kinases. we therefore investigated the differential effects of curcumin in concentation between 1.5 and 13.6 microm on gene expression in t jurkat cd4(+) and human peripheral blood mononuclear cells (pbmcs). relative quantification with reverse transcription real-time pcr (rt-rt-pcr) showed that low concentrations of curcumin sig ... | 2003 | 12614893 |
| ntp toxicology and carcinogenesis studies of turmeric oleoresin (cas no. 8024-37-1) (major component 79%-85% curcumin, cas no. 458-37-7) in f344/n rats and b6c3f1 mice (feed studies). | turmeric oleoresin is the organic extract of turmeric, a ground powder from the root of the curcuma plant, and is added to food items as a spice and coloring agent. turmeric oleoresin, turmeric, and curcumin (the major component found in turmeric) were nominated by the national cancer institute and the food and drug administration for study because these chemicals are used in food items and curry powders, and there was little information on their toxic or carcinogenic properties. pure curcumin w ... | 1993 | 12616304 |
| in vitro curcumin modulates ferric nitrilotriacetate (fe-nta) and hydrogen peroxide (h2o2)-induced peroxidation of microsomal membrane lipids and dna damage. | a number of investigations have implicated the involvement of free radicals in various pathogenic process including initiation/promotion stages of carcinogenesis and antioxidants have been considered to be a protective agent for this reason. an iron chelate, ferric nitrilotriacetate (fe-nta), is a potent nephrotoxic agent and induces acute and subacute renal proximal tubular necrosis by catalyzing the decomposition of hydrogen peroxide-derived production of hydroxyl radicals, which are known to ... | 2003 | 12616605 |
| fungicidal property of curcuma longa l. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse. | fungicidal activity of curcuma longa rhizome-derived materials against botrytis cineria, erysiphe graminis, phytophthora infestans, puccinia recondita, pyricularia oryzae, and rhizoctonia solani was tested using a whole plant method in vivo. it was compared with synthetic fungicides and four commercially available compounds derived from c. longa. the response varied with the tested plant pathogen. at 1000 mg/l, the hexane extract of c. longa showed fungicidal activities against e.graminis, p. in ... | 2003 | 12617587 |
| inhibition of propionibacterium acnes-induced mediators of inflammation by indian herbs. | propionibacterium acnes, an anaerobic pathogen, plays an important role in the pathogenesis of acne by inducing certain inflammatory mediators. these mediators include reactive oxygen species (ros) and pro-inflammatory cytokines. in the present study, ros, interleukin-8 (il-8) and tumor necrosis factor-alpha (tnf-alpha) were used as the major criteria for the evaluation of anti-inflammatory activity. to prove the anti-inflammatory effects of herbs, polymorphonuclear leukocytes (pmnl) and monocyt ... | 2003 | 12622461 |
| curcumin attenuates dnb-induced murine colitis. | numerous therapies used for inflammatory bowel disease (ibd) target the transcription factor nf-kappab, which is involved in the production of cytokines and chemokines integral for inflammation. here we show that curcumin, a component of the spice turmeric, is able to attenuate colitis in the dinitrobenzene sulfonic acid (dnb)-induced murine model of colitis. when given before the induction of colitis it reduced macroscopic damage scores and nf-kappab activation. this was accompanied by a reduct ... | 2003 | 12637253 |
| comparative potencies of nutraceuticals in chemically induced skin tumor prevention. | four nutraceuticals, sugar beet roots, cucumber fruits, new zealand spinach leaves, and turmeric rhizomes, were evaluated for their comparative effectiveness against dimethylbenz[a]anthracene (dmba)-initiated and croton oil-promoted skin tumors. three different protocols were used. the most effective protocol (protocol 2) is the topical application of the nutraceuticals 1 h before croton oil. there was a decrease in the percent skin tumor incidence, a decrease in multiplicity of skin tumors, and ... | 2002 | 12672643 |
| safety and anti-inflammatory activity of curcumin: a component of tumeric (curcuma longa). | tumeric is a spice that comes from the root curcuma longa, a member of the ginger family, zingaberaceae. in ayurveda (indian traditional medicine), tumeric has been used for its medicinal properties for various indications and through different routes of administration, including topically, orally, and by inhalation. curcuminoids are components of tumeric, which include mainly curcumin (diferuloyl methane), demethoxycurcumin, and bisdemethoxycurcmin. | 2003 | 12676044 |
| curcumin exhibits antimetastatic properties by modulating integrin receptors, collagenase activity, and expression of nm23 and e-cadherin. | curcumin (diferuloyl methane), the major pigment from the rhizome of curcuma longa l., has been widely studied for its tumor-inhibiting properties. recent studies indicate that curcumin can modify cell receptor binding, it also affects intracellular signalling reactions. curcumin-treated b16f10 melanoma cells formed eight-fold fewer lung metastases in c57bl6 mice. in the cell adhesion assays, curcumin-treated cells showed a dose-dependent reduction in their binding to four extracellular matrix ( ... | 2003 | 12678405 |
| the molecular mechanisms for the antitumorigenic effect of curcumin. | curcumin, an active yellow pigment of turmeric and curry, possesses anti-inflammatory, antioxidative and anticarcinogenic properties. analysis of its structure revealed the presence of beta-diketone moiety and phenolic hydroxy groups that were believed to contribute to antioxidation. and vanillin, ferulic acid and a dimer of curcumin were identified as the curcumin-derived radical reaction products. in addition to antioxidation, curcumin could also induce apoptosis by targeting mitochondria, aff ... | 2002 | 12678737 |
| anticancer potential of curcumin: preclinical and clinical studies. | curcumin (diferuloylmethane) is a polyphenol derived from the plant curcuma longa, commonly called turmeric. extensive research over the last 50 years has indicated this polyphenol can both prevent and treat cancer. the anticancer potential of curcumin stems from its ability to suppress proliferation of a wide variety of tumor cells, down-regulate transcription factors nf-kappa b, ap-1 and egr-1; down-regulate the expression of cox2, lox, nos, mmp-9, upa, tnf, chemokines, cell surface adhesion m ... | 2003 | 12680238 |
| lens aldose reductase inhibiting potential of some indigenous plants. | cataract is the leading cause of blindness worldover. diabetes is one of the major risk factors for cataractogenesis and aldose reductase (ar) has been reported to play an important role in sugar-induced cataract. in the present study, the ar inhibitory activity of ocimum sanctum (os), withania somnifera (ws), curcuma longa (cl), azadirachta indica (ai) were studied together with their effect on sugar-induced cataractogenic changes in rat lenses in vitro. aqueous extracts of the plants, procured ... | 2003 | 12686449 |
| inhibition of protease-resistant prion protein accumulation in vitro by curcumin. | inhibition of the accumulation of protease-resistant prion protein (prp-res) is a prime strategy in the development of potential transmissible spongiform encephalopathy (tse) therapeutics. here we show that curcumin (diferoylmethane), a major component of the spice turmeric, potently inhibits prp-res accumulation in scrapie agent-infected neuroblastoma cells (50% inhibitory concentration, approximately 10 nm) and partially inhibits the cell-free conversion of prp to prp-res. in vivo studies show ... | 2003 | 12692251 |
| functional properties of spice extracts obtained via supercritical fluid extraction. | in the present study the antioxidant, anticancer, and antimycobacterial activities of extracts from ginger (zingiber officinale roscoe), rosemary (rosmarinus officinalis l.), and turmeric (curcuma longa l.) were evaluated. the extracts were obtained using supercritical co(2) with and without ethanol and/or isopropyl alcohol as cosolvent. the extracts' antioxidant power was assessed using the reaction between beta-carotene and linolenic acid, the antimycobacterial activity against m. tuberculosis ... | 2003 | 12696930 |
| dietary supplementation of curcumin enhances antioxidant and phase ii metabolizing enzymes in ddy male mice: possible role in protection against chemical carcinogenesis and toxicity. | dietary antioxidants protect laboratory animals against the induction of tumours by a variety of chemical carcinogens. among possible mechanism of protection against chemical carcinogenesis could be mediated via-antioxidant-dependent induction of detoxifying enzymes. curcumin, a yellow pigment from curcuma longa, is a major component of turmeric and is commonly used as a spice and food colouring material and exhibits antiinflammatory antitumour, and antioxidant properties. in this study we there ... | 2003 | 12710595 |
| randomised, double-blind, placebo-controlled parallel group study of p54fp for the treatment of dogs with osteoarthritis. | p54fp is an extract of indian and javanese turmeric, curcuma domestica and curcuma xanthorrhiza respectively, which contains a mixture of active ingredients including curcuminoids and essential oils. a randomised, double-blind, placebo-controlled, parallel group clinical trial of p54fp as a treatment for osteoarthritis of the canine elbow or hip was conducted to assess its efficacy and safety. sixty-one client-owned dogs with osteoarthritis were recruited through first-opinion practices and exam ... | 2003 | 12723628 |
| cytoprotective and cytotoxic effects of curcumin: dual action on h2o2-induced oxidative cell damage in ng108-15 cells. | the ability of curcumin, a natural antioxidant isolated from curcuma longa, to inhibit hydrogen peroxide (h(2)o(2))-induced cell damage in ng108-15 cells was examined. when added simultaneously with 500 microm h(2)o(2), curcumin (25-100 microm) effectively protected cells from oxidative damage. however, when the cells were pretreated with curcumin (25-100 microm) for 1.5 h before h(2)o(2) exposure, curcumin was unable to inhibit h(2)o(2)-induced cell damage. instead, it caused a significant conc ... | 2003 | 12736521 |
| in vitro peroxynitrite scavenging activity of diarylheptanoids from curcuma longa. | peroxynitrite is a cytotoxic intermediate produced by the reaction between the superoxide anion (o(2)) and nitric oxide (no). the aim of this study was to investigate the scavenging effects of curcuma longa l. on authentic peroxynitrite, and further studies are planned that will attempt to identify the active principles from the active fractions. the methanolic extract of c. longa showed 50% scavenging activity (ic(50)) at concentration of 1.7 +/- 0.08 micro g/ml, and was thus fractionated with ... | 2003 | 12748983 |
| exploration of melt granulation technique for the development of coprocessed directly compressible adjuvant containing lactose and microcrystalline cellulose. | the objective of the present investigation was to prepare and evaluate lactose and microcrystalline cellulose based, directly compressible adjuvant using melt granulation technique. the percentage of polymer blend (pvp k 30 and peg 4000; 5, 10, or 15%) and the polymer blend ratio (9:1, 1:1, or 1:9) were selected as independent variables in a 3(2) full factorial design. the lactose and microcrystalline cellulose blend (3:1) was mixed with the meltable binder on a water bath at 90 degrees c. the a ... | 2003 | 12760568 |
| curcumin, the major component of food flavour turmeric, reduces mucosal injury in trinitrobenzene sulphonic acid-induced colitis. | 1 inflammmatory bowel disease (ibd) is characterized by oxidative and nitrosative stress, leucocyte infiltration and upregulation of proinflammatory cytokines. in this study, we have investigated the protective effects of curcumin, an anti-inflammatory and antioxidant food derivative, on 2,4,6- trinitrobenzene sulphonic acid-induced colitis in mice, a model for ibd. 2 intestinal lesions (judged by macroscopic and histological score) were associated with neutrophil infiltration (measured as incre ... | 2003 | 12770926 |
| suppression of altered hepatic foci development by curcumin in wistar rats. | curcumin, a yellow pigment of turmeric (curcuma longa), is a commonly used spice and a coloring agent in foods, drugs, and cosmetics. curcumin is known to possess chemopreventive properties in various animal tumor models. in the present study the effect of curcumin on the development of altered hepatic foci (ahf), by using a medium term liver bioassay, has been evaluated. ahf were analyzed by quantitative stereology using the leica qwin image analysis system from frozen liver sections stained fo ... | 2003 | 12791505 |
| effect of curcumin on galactose-induced cataractogenesis in rats. | curcumin, the active principle of turmeric, has been shown to have both antioxidant and hypoglycemic activity in vitro and in vivo. the purpose of this study was to investigate the effect of curcumin on the onset and maturation of galactose induced cataract. | 2003 | 12802258 |
| dietary compounds inhibit proliferation and contraction of keloid and hypertrophic scar-derived fibroblasts in vitro: therapeutic implication for excessive scarring. | keloid and hypertrophic scars commonly occur after injuries. overproliferation of fibroblasts, overproduction of collagen, and contraction characterize these pathologic scars. current treatment of excessive scars with intralesional corticosteroid injections used individually or in combination with other methods often have unsatisfactory outcome, frustrating both the patient and the clinician. the phytochemical compounds are well known as potential anticancer agents. we have investigated the inhi ... | 2003 | 12813346 |
| efficacy and irritancy of enhancers on the in-vitro and in-vivo percutaneous absorption of curcumin. | curcumin is a predominant compound derived from the rhizomes of curcuma longa l., and shows antibacterial, anti-inflammatory and antineoplastic activity. the in-vitro and in-vivo skin absorption of curcumin was investigated after application of enhancers using wistar rat as an animal model. the enhancers selected in this study included terpenes, flavonoids and cholestanol. the irritant profiles of these enhancers were also established by transepidermal water loss (tewl) and histological observat ... | 2003 | 12831501 |
| high-frequency shoot multiplication in curcuma longa l using thidiazuron. | the effects of plant growth regulators, explant types, and culture regimens were investigated on in vitro shoot proliferation from terminal bud explants of curcuma longa. each bud was longitudinally divided into four equal pieces, each 1 cm in length, and used as explants. these were then cultured on ms medium supplemented with 18.17 microm thidiazuron for 4 weeks prior to transfer to ms medium without growth regulator for 8 weeks. under these conditions, a shoot induction rate of 18.22+/-0.62 s ... | 2003 | 12835998 |
| antioxidant activity of smoke shield in-vitro and in-vivo. | smoke shield is a proprietory formulation containing extract of turmeric (curcuma longa), obtained by supercritical carbon dioxide gas extraction and post-supercritical hydroethanolic extraction, together with extracts of green tea and other spices whose presence synergistically increases the activity of turmeric. this study evaluates the antioxidant potentials of smoke shield in-vitro and in experimental animals, as well as in human models. smoke shield was found to scavenge superoxide radicals ... | 2003 | 12841947 |
| curcumin attenuates allergen-induced airway hyperresponsiveness in sensitized guinea pigs. | anti-asthmatic property of curcumin (diferuloylmethane), a natural product from the rhizomes of curcuma longa, has been tested in a guinea pig model of airway hyperresponsiveness. we sensitized guinea pigs with ovalbumin (ova) to develop certain characteristic features of asthma: allergen induced airway constriction and airway hyperreactivity to histamine. guinea pigs were treated with curcumin during sensitization (to examine its preventive effect) or after developing impaired airways features ... | 2003 | 12843631 |
| curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and nf-kappab activation. | recently, there have been considerable efforts to search for naturally occurring substances for the intervention of carcinogenesis. many components derived from dietary or medicinal plants have been found to possess substantial chemopreventive properties. curcumin, a yellow coloring ingredient of turmeric (curcuma longa l., zingiberaceae), has been shown to inhibit experimental carcinogenesis and mutagenesis, but molecular mechanisms underlying its chemopreventive activities remain unclear. in t ... | 2003 | 12844482 |
| screening of antimutagenicity via antioxidant activity in cuban medicinal plants. | the reducing activity on the 1,1-diphenyl-2-picrylhydrazyl (dpph) radical, z.rad;oh radical scavenging potential, in vitro inhibition of lipid peroxidation and modulation of mutagenicity induced by ter-butyl hydroperoxide (tbh) in escherichia coli were sequentially screened in 45 species of plants used with medicinal purposes in cuba, in a search for antioxidant agents which protect dna against oxidative stress.five species, e.g. tamarindus indica l., lippia alba l., pimenta dioica (l.) merr, rh ... | 2003 | 12860316 |
| effects of baicalein, berberine, curcumin and hesperidin on mucin release from airway goblet cells. | baicalein, berberine, curcumin and hesperidin are the major components derived from scutellaria baicalensis, coptis japonica, curcuma longa and poncirus trifoliata, respectively. these plants have been used for the treatment of diverse chronic inflammatory diseases including respiratory disease in oriental medicine and their respective major components were reported to have various biological effects including anti-inflammatory activity. in the present study, we investigated whether these four n ... | 2003 | 12865970 |