Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| microrna-7 functions as a tumor-suppressor gene by regulating ilf2 in pancreatic carcinoma. | interleukin enhancer binding factor 2 (ilf2) has been found to be markedly upregulated in pancreatic carcinoma and is involved in the pathogenesis of pancreatic carcinoma. thus, ilf2 may be a potential target for therapy. yet, the regulatory mechanisms of ilf2 in pancreatic carcinoma remain largely elusive. in the present study, we demonstrated that ilf2 functioned as an oncogene and regulated epithelial-mesenchymal transition (emt)-associated genes in pancreatic carcinoma panc-1 cells. microrna ... | 2017 | 28259961 |
| possible role of common spices as a preventive and therapeutic agent for alzheimer's disease. | for centuries, spices have been consumed as food additives or medicinal agents. however, there is increasing evidence indicating the plant-based foods in regular diet may lower the risk of neurodegenerative diseases including alzheimer disease. spices, as one of the most commonly used plant-based food additives may provide more than just flavors, but as agents that may prevent or even halt neurodegenerative processes associated with aging. in this article, we review the role and application of f ... | 2017 | 28250905 |
| synthetic curcumin derivative dk1 possessed g2/m arrest and induced apoptosis through accumulation of intracellular ros in mcf-7 breast cancer cells. | curcumin is a lead compound of the rhizomes of curcuma longa and possess a broad range of pharmacological activities. chemically, curcumin is 1,3-dicarbonyl class of compound, which exhibits keto-enol tautomerism. despite of its strong biological properties, curcumin has yet been recommended as a therapeutic agent because of its poor bioavailability. | 2017 | 28239299 |
| clinical use of curcumin in depression: a meta-analysis. | there is growing interest in the use of curcumin, a plant polyphenol with potent anti-inflammatory, anti-oxidant, and neuroprotective properties, as a novel antidepressant. clinical trials have yielded conflicting conclusions pertaining to its effectiveness in depression. a meta-analysis of the topic, which has not been done until now, is therefore necessary to summarize current evidence and generate hypotheses for further research. | 2017 | 28236605 |
| claudin-3 and occludin content in the glands of colonic mucosa devoid from fecal stream submitted to topical intervention with oil extract of curcuma longa. | to evaluate the inflammatory intensity and measure the tissue content of the proteins claudin-3 and occludin in the colonic mucosa without fecal stream submit to intervention with curcumin. | 2017 | 28225919 |
| curcumin attenuates surgery-induced cognitive dysfunction in aged mice. | post-operative cognitive dysfunction (pocd) is associated with elderly patients undergoing surgery. however, pharmacological treatments for pocd are limited. in this study, we found that curcumin, an active compound derived from curcuma longa, ameliorated the cognitive dysfunction following abdominal surgery in aged mice. further, curcumin prevented surgery-induced anti-oxidant enzyme activity. curcumin also increased brain-derived neurotrophic factor (bdnf)-positive area and expression of pakt ... | 2017 | 28224377 |
| curcumin inhibits cancer progression through regulating expression of micrornas. | curcumin, a major yellow pigment and spice in turmeric and curry, is a powerful anti-cancer agent. the anti-tumor activities of curcumin include inhibition of tumor proliferation, angiogenesis, invasion and metastasis, induction of tumor apoptosis, increase of chemotherapy sensitivity, and regulation of cell cycle and cancer stem cell, indicating that curcumin maybe a strong therapeutic potential through modulating various cancer progression. it has been reported that micrornas as small noncodin ... | 2017 | 28222667 |
| a bioprocessed polysaccharide from lentinus edodes mycelia cultures with turmeric protects chicks from a lethal challenge of salmonella gallinarum. | our previous studies demonstrated that a bioprocessed polysaccharide (bpp) isolated from lentinus edodes mushroom mycelia cultures supplemented with black rice bran can protect mice against salmonella lipopolysaccharide-induced endotoxemia and reduce the mortality from salmonella typhimurium infection through upregulated t-helper 1 immunity. here, we report that a bpp from l. edodes mushroom mycelia liquid cultures supplemented with turmeric (referred to as bpp-turmeric) alters chicken macrophag ... | 2017 | 28221973 |
| curcumin-functionalized silk biomaterials for anti-aging utility. | curcumin is a natural antioxidant that is isolated from turmeric (curcuma longa) and exhibits strong free radical scavenging activity, thus functional for anti-aging. however, poor stability and low solubility of curcumin in aqueous conditions limit its biomedical applications. previous studies have shown that the anti-oxidation activity of curcumin embedded in silk fibroin films could be well preserved, resulting in the promoted adipogenesis from human mesenchymal stem cells (hmscs) cultured on ... | 2017 | 28214625 |
| pharmacogenomic characterization and isobologram analysis of the combination of ascorbic acid and curcumin-two main metabolites of curcuma longa-in cancer cells. | curcuma longa has long been used in china and india as anti-inflammatory agent to treat a wide variety of conditions and also as a spice for varied curry preparations. the chemoprofile of the curcuma species exhibits the presence of varied phytochemicals with curcumin being present in all three species but aa only being shown in c. longa. this study explored the effect of a curcumin/aa combination on human cancer cell lines. the curcumin/aa combination was assessed by isobologram analysis using ... | 2017 | 28210221 |
| analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects. | the optimal health benefits of curcumin are limited by its low solubility in water and corresponding poor intestinal absorption. cyclodextrins (cd) can form inclusion complexes on a molecular basis with lipophilic compounds, thereby improving aqueous solubility, dispersibility, and absorption. in this study, we investigated the bioavailability of a new γ-cyclodextrin curcumin formulation (cw8). this formulation was compared to a standardized unformulated curcumin extract (stdc) and two commercia ... | 2017 | 28204880 |
| effects of curcumin on serum vitamin e concentrations in individuals with metabolic syndrome. | vitamin e is an important lipid-soluble antioxidant. the aim of the present study was to investigate the effect of curcumin on serum vitamin e levels in subjects with metabolic syndrome (mets). a total of 120 subjects aged 18-65 years old with mets were recruited in this study according to the international diabetic federation criteria. included subjects were randomized into three groups: subjects receiving lecithinized curcumin (1 g/day equivalent to 200-mg pure curcumin per day) for a period o ... | 2017 | 28198120 |
| curcumin attenuates titanium particle-induced inflammation by regulating macrophage polarization in vitro and in vivo. | periprosthetic inflammatory osteolysis and subsequent aseptic loosening are commonly observed in total joint arthroplasty. other than revision surgery, few approved treatments are available for this complication. wear particle-induced inflammation and macrophage polarization state play critical roles in periprosthetic osteolysis. we investigated the effects of curcumin, a polyphenol extracted from curcuma longa, on titanium (ti) particle-induced inflammation and macrophage polarization in vitro ... | 2017 | 28197150 |
| dual functional mesoporous silicon nanoparticles enhance the radiosensitivity of vpa in glioblastoma. | radiotherapy is a critical strategy and standard adjuvant approach to glioblastoma treatment. one of the major challenges facing radiotherapy is to minimize radiation damage to normal tissue without compromising therapeutic effects on cancer cells. various agents and numerous approaches have been developed to improve the therapeutic index of radiotherapy. among them, radiosensitizers have attracted much attention because they selectively increase susceptibility of cancer cells to radiation and t ... | 2017 | 28193559 |
| effects of curcumin on hdl functionality. | curcumin, a bioactive polyphenol, is a yellow pigment of the curcuma longa (turmeric) plant. curcumin has many pharmacologic effects including antioxidant, anti-carcinogenic, anti-obesity, anti-angiogenic and anti-inflammatory properties. recently, it has been found that curcumin affects lipid metabolism, and subsequently, may alleviate hyperlipidemia and atherosclerosis. plasma hdl cholesterol (hdl-c) is an independent negative risk predictor of cardiovascular disease (cvd). however, numerous c ... | 2017 | 28192240 |
| cytotoxic and apoptotic effects of the combination of palladium (ii) 5,5-diethylbarbiturate complex with bis(2-pyridylmethyl)amine and curcumin on non small lung cancer cell lines. | metal-based chemotherapeutics such as cisplatin are widely used treatment of lung cancer which is the major cause of cancer-related mortality worldwide. recent studies demonstrated that novel metal-based compounds have strong cytotoxic activity in a similar way as cisplatin. therefore, metal-based compounds have been synthesized and investigated in order to determine their cytotoxic activities. it has been also reported curcumin, which has been derived from turmeric plant, has powerful cytotoxic ... | 2017 | 28187956 |
| a placebo-controlled double-blinded randomized pilot study of combination phytotherapy in biochemically recurrent prostate cancer. | men with biochemical recurrence of prostate cancer following local therapies often use natural supplements in an attempt to delay metastases and/or avoid the need for more aggressive treatments with undesirable side-effects. while there is a growing body of research into phytotherapeutic agents in this cohort, with some promising results, as yet no definitive recommendations can be made. this pilot study was undertaken to assess the feasibility of a fully-powered study to examine the effects of ... | 2017 | 28181675 |
| the effects of curcuminoids on musculoskeletal pain: a systematic review. | western countries are increasingly using complementary and alternative medicine (cam) to assist with relieving ailments. turmeric, from the ginger family zingiberaceae, has a history of use for medicinal purposes. the polyphenols found in turmeric (curcuminoids) have demonstrated anti-inflammatory and pain relieving properties. with the use of cams increasing, it is important for the effectiveness of curcuminoids to be established. | 2017 | 28178024 |
| curcumin inhibits growth potential by g1 cell cycle arrest and induces apoptosis in p53-mutated colo 320dm human colon adenocarcinoma cells. | curcumin, a natural polyphenolic compound and it is isolated from the rhizome of curcuma longa, have been reported to possess anticancer effect against stage i and ii colon cancer. however, the effect of curcumin on colon cancer at dukes' type c metastatic stage iii remains still unclear. in the present study, we have investigated the anticancer effects of curcumin on p53 mutated colo 320dm human colon adenocarcinoma cells derived from dukes' type c metastatic stage. the cellular viability and p ... | 2017 | 28011386 |
| assessing saffron (crocus sativus l.) adulteration with plant-derived adulterants by diffuse reflectance infrared fourier transform spectroscopy coupled with chemometrics. | saffron, the dried red stigmas of the plant crocus sativus l., is well-known as one of the most important and expensive spices worldwide. it is thus highly susceptible to fraudulent practices that employ, among others, plant-derived adulterants. this study presents an application of diffuse reflectance infrared fourier transform spectroscopy (drifts) and chemometric techniques for evaluating adulteration of saffron with six characteristic adulterants of plant origin, i.e. c. sativus stamens, cal ... | 2017 | 27837871 |
| evidence for the participation of acid-sensing ion channels (asics) in the antinociceptive effect of curcumin in a formalin-induced orofacial inflammatory model. | curcumin, a major bioactive component of turmeric, has diverse therapeutic effects such as anti-inflammatory, antioxidant, anticancer, and antinociceptive activities. the acid-sensing ion channels (asics), which can be activated by acute drops in the extracellular ph, play an important role in nociception. however, very little is known about the interaction between asics and curcumin in nociception of inflammation. in our study, we investigated whether the antinociceptive effects of curcumin are ... | 2017 | 27383838 |
| cytologic follow up of low-grade squamous intraepithelial lesions in pap smears after integrated treatment with antimicrobials followed by oral turmeric oil extract. | cervical cancer is preventable because the carcinogenesis is slow and there are opportunities to detect precancerous lesions by papanicolaou (pap) smears, colposcopy, or hpv dna tests and to treat them by antimicrobials, surgery or cold co2 vapourization. we have earlier reported on the chemopreventive potential of integrated treatment with antimicrobials therapy followed by a standardized oral turmeric oil (to) extract upto 12 weeks in women who had persistent low-grade squamous intra-epithelia ... | 2017 | 27475746 |
| novel delivery system for natural products: nano-curcumin formulations. | curcumin is extracted from curcuma longa and regulates the intracellular signal pathways which control the growth of cancerous cell, inflammation, invasion and apoptosis. curcumin molecules have special intrinsic features that can target the intracellular enzymes, genome (dna) and messengers (rna). a wide range of studies have been conducted on the physicochemical traits and pharmacological effects of curcumin on different diseases like cardiovascular diseases, diabetes, cancer, rheumatoid arthr ... | 2017 | 27516979 |
| a systems biology approach for elucidating the interaction of curcumin with fanconi anemia fanc g protein and the key disease targets of leukemia. | fanconi anemia (fa) is an autosomal recessive disorder with a high risk of malignancies including acute myeloid leukemia and squamous cell carcinoma. there is a constant search out of new potential therapeutic molecule to combat this disorder. in most cases, patients with fa develop haematological malignancies with acute myeloid leukemia and acute lymphoblastic leukemia. identifying drugs which can efficiently block the pathways of both these disorders can be an ideal and novel strategy to treat ... | 2017 | 27608133 |
| antidotal effects of curcumin against agents-induced cardiovascular toxicity. | curcumin, the major phenolic compound in turmeric, shows preventive effects in various diseases. curcumin is commonly found in rhizome of the curcuma species and traditionally used in herbal medicine. numeros studies has indicated that curcumin posses protective effects against toxic agents in various systems including cardiovascular. this study found that curcumin may be effective in cardiovascular diseases induced by toxic agents including streptozotocin, doxorubicin, cyclosporin a, methotrexa ... | 2017 | 27492624 |
| curcumin improves episodic memory in cadmium induced memory impairment through inhibition of acetylcholinesterase and adenosine deaminase activities in a rat model. | curcumin, the main polyphenolic component of turmeric (curcuma longa) rhizomes has been reported to exert cognitive enhancing potential with limited scientific basis. hence, this study sought to evaluate the effect of curcumin on cerebral cortex acetylcholinesterase (ache) and adenosine deaminase (ada) activities in cadmium (cd)-induced memory impairment in rats. animals were divided into six groups (n = 6): saline/vehicle, saline/curcumin 12.5 mg/kg, saline/curcumin 25 mg/kg, cd/vehicle, cd/cur ... | 2017 | 27491636 |
| immunomodulatory effects of turmeric: proliferation of spleen cells in mice. | experiments were conducted to examine the effects of turmeric on spleen cell proliferation. cell suspensions of spleen cells from young and aged mice were treated with or without conconavalin a (con-a) as a proliferation stimulant, and with and without turmeric (20 mg/ml) in different concentrations. spleen cells from young mice that received turmeric showed significant increase in spleen cell proliferation (p < 0.05), while spleen cells from aged mice that received turmeric showed no significan ... | 2017 | 27559614 |
| management of parkinson's disease in ayurveda: medicinal plants and adjuvant measures. | medicinal plants like mucuna pruriens l.(dc) and withania somnifera l.(dunal) have been used in traditional ayurvedic medicine to manage neurodegenerative diseases like parkinson's disease. | 2017 | 27544001 |
| curcumin encapsulated into methoxy poly(ethylene glycol) poly(ε-caprolactone) nanoparticles increases cellular uptake and neuroprotective effect in glioma cells. | curcumin is a natural polyphenolic compound isolated from turmeric (curcuma longa) with well-demonstrated neuroprotective and anticancer activities. although curcumin is safe even at high doses in humans, it exhibits poor bioavailability, mainly due to poor absorption, fast metabolism, and rapid systemic elimination. to overcome these issues, several approaches, such as nanoparticle-mediated targeted delivery, have been undertaken with different degrees of success. the present study was conducte ... | 2017 | 27626946 |
| spices in the management of diabetes mellitus. | diabetes mellitus (dm) remains a major health care problem worldwide both in developing and developed countries. many factors, including age, obesity, sex, and diet, are involved in the etiology of dm. nowadays, drug and dietetic therapies are the two major approaches used for prevention and control of dm. compared to drug therapy, a resurgence of interest in using diet to manage and treat dm has emerged in recent years. conventional dietary methods to treat dm include the use of culinary herbs ... | 2017 | 27664636 |
| effects of curcumin in experimental diabetic nephropathy. | diabetic nephropathy (dn) is currently well established as the most common cause of end-stage renal disease in most parts of the world. notwithstanding the expanding basic and clinical research in this field, the pathogenesis remains far from clear and hence the treatment of dn remains suboptimal. there is a critical need for the development of newer therapeutic strategies including alternative and complementary therapies. one of the natural products that was extensively studied in cancer and ot ... | 2017 | 27683729 |
| an integrated strategy for establishment of curcuminoid profile in turmeric using two lc-ms/ms platforms. | turmeric and curcuminoids are used as natural food coloring and functional food additives in various parts of the world. in this study, ninety-six curcuminoids were fully characterized using a targeted curcuminoid profile, which established by integrated use of two complementary lc-ms/ms platforms (liquid chromatography-quadrupole time of flight mass spectrometry (lc-qtof-ms/ms) and liquid chromatography-quadrupole linear ion trap mass spectrometry (lc-qtrap-ms/ms)). the curcuminoid profile was ... | 2017 | 27697575 |
| quantitative determination of xanthorrhizol in rat plasma by hplc-ms/ms and its application to a pharmacokinetic study. | although xanthorrhizol, a sesquiterpenoid oil isolated from the rhizoma of curcuma xanthorrhiza roxb. known as java turmeric, represents a variety of pharmacological activities, to date, there have been no validated determination methods of xanthorrhizol in biological samples. thus, we developed a liquid chromatographic method using a tandem mass spectrometry for the determination of xanthorrhizol in rat plasma. after simple protein precipitation with acetonitrile including diclofenac (internal ... | 2017 | 27693953 |
| fabrication of aptamer decorated dextran coated nano-graphene oxide for targeted drug delivery. | in the current study, dextran (dex) was covalently conjugated to the surface of nano-go sheets, making stable biocompatible dextran coated go (go-dex). the prepared go-dex was nontoxic to 4t1 mammary carcinoma cell line at concentrations up to 300μg/ml. as1411 aptamer, a ssdna aptamer which can improve the intracellular uptake by nucleolin recognition, also has been introduced to hydroxyl groups of dex in go-dex to produce go-dex-apt. moreover, curcumin (cur), a natural polyphenol, found in the ... | 2017 | 27702507 |
| efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: a randomised, double-blind, placebo-controlled study. | several studies have supported the antidepressant effects of curcumin (from the spice turmeric) and saffron for people with major depressive disorder. however, these studies have been hampered by poor designs, small sample sizes, short treatment duration, and similar intervention dosages. furthermore, the antidepressant effects of combined curcumin and saffron administration are unknown. | 2017 | 27723543 |
| curcumin as a natural regulator of monocyte chemoattractant protein-1. | monocyte chemoattractant/chemotactic protein-1 (mcp-1), a member of the cc chemokine family, is one of the key chemokines that regulate migration and tissue infiltration of monocytes/macrophages. its role in the pathophysiology of several inflammatory diseases has been widely recognized, thus making mcp-1 a possible target for anti-inflammatory treatments. curcumin (diferuloylmethane) is a natural polyphenol derived from the rhizomes of curcuma longa l. (turmeric). anti-inflammatory action under ... | 2017 | 27743775 |
| transepithelial transport of curcumin in caco-2 cells is significantly enhanced by micellar solubilisation. | curcumin, the active constituent of curcuma longa l. (family zingiberaceae), has gained increasing interest because of its anti-cancer, anti-inflammatory, anti-diabetic, and anti-rheumatic properties associated with good tolerability and safety up to very high doses of 12 g. nanoscaled micellar formulations on the base of tween 80 represent a promising strategy to overcome its low oral bioavailability. we therefore aimed to investigate the uptake and transepithelial transport of native curcumin ... | 2017 | 27900602 |
| curcumin: an effective adjunct in patients with statin-associated muscle symptoms? | in spite of the unequivocal efficacy of statins in reducing primary and secondary cardiovascular events, the use of these drugs in a considerable number of patients is limited because of statin intolerance, mainly statin-associated muscle symptoms (sams). sams encompass a broad spectrum of clinical presentations, including mild muscular aching and other types of myalgias, myopathy with the significant elevation of creatine kinase, and the rare but life-threatening rhabdomyolysis. among several p ... | 2017 | 27897416 |
| mycotoxins in spices and herbs-an update. | spices and herbs have been used since ancient times as flavor and aroma enhancers, colorants, preservatives, and traditional medicines. there are more than 30 spices and herbs of global economic and culinary importance. among the spices, black pepper, capsicums, cumin, cinnamon, nutmeg, ginger, turmeric, saffron, coriander, cloves, dill, mint, thyme, sesame seed, mustard seed, and curry powder are the most popular spices worldwide. in addition to their culinary uses, a number of functional prope ... | 2017 | 26528824 |
| cytotoxic and antitumor effects of curzerene from curcuma longa. | curzerene is a sesquiterpene and component used in oriental medicine. it was originally isolated from the traditional chinese herbal medicine curcuma rhizomes. in this study, anticancer activity of curzerene was examined in both in vitro and in vivo models. the result of the mtt assay showed that curzerene exhibited antiproliferative effects in spc-a1 human lung adenocarcinoma cells in a time-dependent and dose-dependent manner. the anticancer ic50s were 403.8, 154.8, and 47.0 µm for 24, 48, and ... | 2017 | 27286338 |
| modulation of camp levels by high-fat diet and curcumin and regulatory effects on cd36/fat scavenger receptor/fatty acids transporter gene expression. | curcumin, a polyphenol from turmeric (curcuma longa), reduces inflammation, atherosclerosis, and obesity in several animal studies. in ldlr(-/-) mice fed a high-fat diet (hfd), curcumin reduces plasma lipid levels, therefore contributing to a lower accumulation of lipids and to reduced expression of fatty acid transport proteins (cd36/fat, fabp4/ap2) in peritoneal macrophages. in this study, we analyzed the molecular mechanisms by which curcumin (500, 1000, 1500 mg/kg diet, for 4 months) may inf ... | 2017 | 27355903 |
| combined antiparasitic and anti-inflammatory effects of the natural polyphenol curcumin on turbot scuticociliatosis. | the histiophagous scuticociliate philasterides dicentrarchi is the aetiological agent of scuticociliatosis, a parasitic disease of farmed turbot. curcumin, a polyphenol from curcuma longa (turmeric), is known to have antioxidant and anti-inflammatory properties. we investigated the in vitro effects of curcumin on the growth of p. dicentrarchi and on the production of pro-inflammatory cytokines in turbot leucocytes activated by parasite cysteine proteases. at 100 μm, curcumin had a cytotoxic effe ... | 2017 | 27334368 |
| turmeric effect on subcutaneous insulin-induced amyloid mass: an in vivo study. | protein-derived amyloid structures are associated with a wide variety of pathologies, including neurodegenerative diseases and local amyloidoses. reports exist on the ability of insulin to form local amyloidoses under specific conditions. in vitro-generated fibrils of insulin have been previously shown to produce amyloid-containing masses upon repetitive subcutaneous injection in mouse. the present study aimed at investigating the effect of insulin fibrils injection in rats, as well as the poten ... | 2017 | 27079769 |
| ovalbumin-induced allergic inflammation lead to structural alterations in mouse model and protective effects of intranasal curcumin: a comparative study. | antigen exposure and persistent inflammation leads to structural changes in the asthmatic airways which are collectively termed as "airway remodelling". presently available asthma medications ameliorate inflammations but are unable to prevent or reverse the airway remodelling process as most of the treatment strategies are only focused on inflammation instead of remodelling. | 2017 | 27046748 |
| turmeric (curcuma longa): effects of curcuma longa extracts compared with ibuprofen for reduction of pain and functional improvement in patients with knee osteoarthritis. | 2017 | 27078813 | |
| synthetic and medicinal prospective of structurally modified curcumins. | curcumin, a natural yellow phenolic compound, is present in various types of herbs, particularly in turmeric, curcuma longa linn. (zingiberaceae family) rhizomes. curcumin is a polyphenolic natural compound with diverse and attractive biological activities. in the last decade curcumine and its various synthetic analogues have been prepared and evaluated for various pharmacological activities that prove it as a lead molecule against several biological targets. it is a natural antioxidant and exhi ... | 2017 | 27280465 |
| adriamycin-induced oxidative stress is prevented by mixed hydro-alcoholic extract of nigella sativa and curcuma longa in rat kidney. | inflammation and oxidative stress is considered to have a crucial role in induction of nephropathy. curcuma longa (c. longa) and nigella sativa (n. sativa) have anti-inflammatory and antioxidant effects. this study was designed to investigate the effect of mixed hydro-alcoholic extract of n.sativa and c. longa on the oxidative stress induced by adriamycin (adr) in rat kidney. | 2017 | 27247925 |
| efficacy of curcuma for treatment of osteoarthritis. | the objective of this review is to identify, summarize, and evaluate clinical trials to determine the efficacy of curcuma in the treatment of osteoarthritis. a literature search for interventional studies assessing efficacy of curcuma was performed, resulting in 8 clinical trials. studies have investigated the effect of curcuma on pain, stiffness, and functionality in patients with knee osteoarthritis. curcuma-containing products consistently demonstrated statistically significant improvement in ... | 2017 | 26976085 |
| comparative evaluation of turmeric gel with 2% chlorhexidine gluconate gel for treatment of plaque induced gingivitis: a randomized controlled clinical trial. | ayurveda is regarded as most ancient traditional system of medicine originated in india having its root back in the vedas. medicinal herbs have been long employed to improve the oral health by means of frequently used therapeutic procedures kavala (gargling) and gandusha (holding of medicated liquids in the mouth). gingivitis is most common ailment that results in bleeding gums and halitosis. | 2017 | 27011714 |
| new dendrimer-based nanoparticles enhance curcumin solubility. | curcumin, the main curcuminoid of the popular indian spice turmeric, is a potent chemopreventive agent and useful in many different diseases. a major limitation of applicability of curcumin as a health promoting and medicinal agent is its extremely low bioavailability due to efficient first pass metabolism, poor gastrointestinal absorption, rapid elimination, and poor aqueous solubility. in the present study, nanotechnology was selected as a choice approach to enhance the bioavailability of the ... | 2017 | 27002394 |
| molecular mechanisms of cholangiocarcinoma cell inhibition by medicinal plants. | cholangiocarcinoma (cca) is one of the most common causes of cancer-associated mortality in thailand. certain phytochemicals have been demonstrated to modulate apoptotic signaling pathways, which may be targeted for the prevention and treatment of cancer. therefore, the aim of the present study was to investigate the effect of specific medicinal plants on the inhibition of cca cell proliferation, and to identify the molecular mechanisms underlying this. a wst-1 cell proliferation assay was perfo ... | 2017 | 28356985 |
| up1304, a botanical composition containing two standardized extracts of curcuma longa and morus alba, mitigates pain and inflammation in adjuvant-induced arthritic rats. | though, the initial etiologies of arthritis are multifactorial, clinically, patients share pain as the prime complaints. present day pain relief therapeutics heavily relies on the use of prescription and over the counter nonsteroidal anti-inflammatory drugs as the first line of defense where their long-term usage causes gastrointestinal and cardiovascular-related side effects. hence, the need for evidence-based safer and efficacious alternatives from natural sources to overcome the most prominen ... | 2017 | 27034601 |
| oxidative metabolism of curcumin-glucuronide by peroxidases and isolated human leukocytes. | conjugation with glucuronic acid is a prevalent metabolic pathway of orally administrated curcumin, the bioactive diphenol of the spice turmeric. the major in vitro degradation reaction of curcumin is autoxidative transformation resulting in oxygenation and cyclization of the heptadienedione chain to form cyclopentadione derivatives. here we show that curcumin-glucuronide is much more stable than curcumin, degrading about two orders of magnitude slower. horseradish peroxidase-catalyzed oxidation ... | 2017 | 28274615 |
| effect of neem oil and haridra on non-healing wounds. | in ayurveda, vrana (wound) has stated as tissue destruction and discoloration of viable tissue due to various etiology. in sushruta samhita, sushruta described vrana as a main subject. most commonly vrana can be classified into shuddha and dushta vrana (chronic wound/nonhealing ulcers). among the various drugs mentioned for dushta vrana, two of them, neem (azadirechta indica a. juss) oil and haridra (curcuma longa linn.) powder are selected for their wide spectrum action on wound. | 2017 | 26195902 |
| the effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (erα) in breast cancer cells. | curcumin (cur) is a compound that has antibacterial, antiviral, anti-inflammatory, and anticancer properties. in this study, we have analyzed the effects of cur on the expression of erα and p53 in the presence of hormones and anti-hormones in breast cancer cells. cells were cultured in a medium containing charcoal-stripped fetal bovine serum to deplete any endogenous steroids and treated with cur at varying concentrations or in combination with hormones and anti-hormones. protein analysis reveal ... | 2017 | 28331366 |
| ameliorative effect of two ayurvedic herbs on experimentally induced arsenic toxicity in calves. | chronic arsenic poisoning due to contaminated subsoil water is a threat to society in west bengal, india and in bangladesh. the human being may also be affected by the exposed cattle from the affected area by consuming milk, egg, meat and others. in ayurveda, several herbs like haridra (turmeric), shunthi (dried ginger root) and others are used for the management of arsenic poisoning. | 2017 | 27496583 |
| antimicrobial and physical properties of chitosan films incorporated with turmeric extract. | in this study, the effects of turmeric extract incorporation on the antibacterial and physical properties of the chitosan films were evaluated. turmeric containing chitosan-based film was produced with casting procedure and cross-linked with sodium sulfate. mechanical, optical, thermal properties, and water vapor permeability of the films were studied. the addition of turmeric to chitosan film significantly increased the tensile strength of the film and improved the ultraviolet-visible light bar ... | 2017 | 28366856 |
| in situ development and application of natural coatings on non-absorbable sutures to reduce incision site infections. | the purpose of the study was the development of a suture line that has antibacterial properties and reduces the chance of wound infection thus facilitating the healing process. | 2017 | 28277992 |
| the antimalarial effect of curcumin is mediated by the inhibition of glycogen synthase kinase-3β. | curcumin, a bioactive compound in curcuma longa, exhibits various pharmacological activities, including antimalarial effects. in silico docking simulation studies suggest that curcumin possesses glycogen synthase kinase-3β (gsk3β)-inhibitory properties. the involvement of gsk3 in the antimalarial effects in vivo is yet to be demonstrated. in this study, we aimed to evaluate whether the antimalarial effects of curcumin involve phosphorylation of host gsk3β. intraperitoneal administration of curcu ... | 2017 | 28146408 |
| the effectiveness of natural diarylheptanoids against trypanosoma cruzi: cytotoxicity, ultrastructural alterations and molecular modeling studies. | curcumin (cur) is the major constituent of the rhizomes of curcuma longa and has been widely investigated for its chemotherapeutic properties. the well-known activity of cur against leishmania sp., trypanosoma brucei and plasmodium falciparum led us to investigate its activity against trypanosoma cruzi. in this work, we tested the cytotoxic effects of cur and other natural curcuminoids on different forms of t. cruzi, as well as the ultrastructural changes induced in epimastigote form of the para ... | 2017 | 27658305 |
| preventive effects of curcumin against drug- and starvation-induced gastric erosions in rats. | the present study was designed to investigate the gastroprotective, analgesic, and antipyretic effects of curcumin (cur), the major constituent of turmeric. acetylsalicylic acid (asa) was used in this study as a standard drug for comparison. the analgesic activity was measured using the hot-plate test. the antipyretic and antiulcer effects were assessed using yeast-induced pyrexia and gastric ulceration, respectively. curcumin (100 mg/kg) injected intra-peritoneally 1 hr prior to the hot-plate t ... | 2017 | 23833720 |
| anti-cholelithogenic potential of dietary spices and their bioactives. | dietary hypocholesterolemic spices-curcumin (active compound of turmeric (curcuma longa)) and capsaicin (active compound of red pepper (capsicum annuum)), the active principles of spices-turmeric (curcuma longa) and red pepper (capsicum annuum), fenugreek (trigonella foenum-graecum) seeds, garlic (allium sativum), and onion (allium cepa) are documented to have anti-cholelithogenic property in animal model. these spices prevent the induction of cholesterol gallstones by lithogenic high cholestero ... | 2017 | 26147513 |
| anticancer potential of nutraceutical formulations in mnu-induced mammary cancer in sprague dawley rats. | nutraceuticals help in combating some of the major health problems of the century including cancer, and 'nutraceutical formulations' have led to the new era of medicine and health. | 2017 | 28216882 |
| ethnobotanics used in folk medicine of tamil culture in sri lanka: a scientific review. | tamil culture has recognized the potential use of plant herbs for prevention and treatment of different diseases. these folk remedies have been practiced by sri lankan tamils even after modernization. this review focuses on frequently used medicinal plants among sri lankan tamil communities, such as cuminum cyminum, azadirechta indica, coriandrum sativum, sesamum indicum, zingiber officinale, trigonella foenum-graecum, moringa oleifera, plectranthus amboinicus, allium sativum and curcuma longa, ... | 2017 | 28088256 |
| anthelmintic potential of thymoquinone and curcumin on fasciola gigantica. | fasciolosis an economically important global disease of ruminants in the temperate and tropical regions, caused by fasciola hepatica and f. gigantica, respectively, also poses a potential zoonotic threat. in india alone it causes huge losses to stakeholders. anthelmintics including triclabendazole have been used to control this menace but the emerging resistance against the available compounds necessitates identification of novel and alternative therapeutic measures involving plant derived natur ... | 2017 | 28152102 |
| enhanced anti-cancer and antimicrobial activities of curcumin nanoparticles. | background curcumin (diferuloylmethane) is a polyphenol derived from the plant curcuma longa, commonly called turmeric. extensive research over the last 50 years has demonstrated that these polyphenols play an important role in the maintenance of health and prevention of diseases, in addition to its therapeutic benefits such as anti-tumor, anti-inflammatory, and anti-oxidant activities. materials and methods this study is devoted to the enhancement of the solubility and bioavailability of curcum ... | 2017 | 26747522 |
| effects of curcuma longa rhizome powder on egg quality, performance and some physiological indices of laying hens fed different levels of metabolizable energy. | high-energy diets of laying hens may improve roductive performance, although some negative effects may also appear with respect to egg quality and physiological parameters. curcuma longa rhizome powder (crp) has beneficial effects on health indices of the birds through antioxidant and antimicrobial properties, especially when the birds experience nutritional stress. | 2017 | 27328772 |
| production of curcuminoids in engineered escherichia coli. | curcumin, a hydrophobic polyphenol derived from the rhizome of the herb curcuma longa, possesses diverse pharmacological properties including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activity. two curcuminoids (dicinnamoylmethane and bisdemethoxycurcumin) were synthesized from glucose in escherichia coli. pal (phenylalanine ammonia lyase) or tal (tyrosine ammonia lyase), along with os4cl (p-coumaroyl-coa ligase) and cus (curcumin synthase), were introduced in to e. co ... | 2017 | 28274102 |
| facile preparation of water soluble curcuminoids extracted from turmeric (curcuma longa l.) powder by using steviol glucosides. | curcuminoids from rhizomes of curcuma longa possess various biological activities. however, low aqueous solubility and consequent poor bioavailability of curcuminoids are major limitations to their use. in this study, curcuminoids extracted from turmeric powder using stevioside (ste), rebaudioside a (reba), or steviol glucosides (sg) were solubilized in water. the optimum extraction condition by ste, reba, or sg resulted in 11.3, 9.7, or 6.7mg/ml water soluble curcuminoids. curcuminoids solubili ... | 2017 | 27507487 |
| curcumin inhibits zika and chikungunya virus infection by inhibiting cell binding. | several compounds extracted from spices and herbs exhibit antiviral effects in vitro, suggesting potential pharmacological uses. curcumin, a component of turmeric, has been used as a food additive and herbal supplement due to its potential medicinal properties. previously, curcumin exhibited antiviral properties against several viruses, including dengue virus and hepatitis c virus, among others. here, we describe the antiviral effect of curcumin on zika and chikungunya viruses, two mosquito-born ... | 2017 | 28343845 |
| novel insight from computational virtual screening depict the binding potential of selected phytotherapeutics against probable drug targets of clostridium difficile. | this study explores computational screening and molecular docking approaches to screen novel herbal therapeutics against probable drug targets of clostridium difficile. the essential genes were predicted by comparative genome analysis of c. difficile and best homologous organisms using blast search at database of essential genes (deg). the functions of these genes in various metabolic pathways were predicted and some of these genes were considered as potential targets. three major proteins were ... | 2017 | 28217823 |
| termitarium-inhabiting bacillus spp. enhanced plant growth and bioactive component in turmeric (curcuma longa l.). | curcumin (diferuloyl methane) is the main bioactive component of turmeric (curcuma longa l.) having remarkable multipotent medicinal and therapeutic applications. two bacilli isolated from termitarium soil and identified as bacillus endophyticus tsh42 and bacillus cereus tsh77 were used for bacterization of rhizome for raising c. longa ver. suguna for growth and enhancement. both the strains showed remarkable pgp activities and also chemotactic in nature with high chemotactic index. turmeric pla ... | 2017 | 27913879 |
| mechanisms of antifungal and anti-aflatoxigenic properties of essential oil derived from turmeric (curcuma longa l.) on aspergillus flavus. | the antifungal activity and potential mechanisms in vitro as well as anti-aflatoxigenic efficiency in vivo of natural essential oil (eo) derived from turmeric (curcuma longa l.) against aspergillus flavus was intensively investigated. based on the previous chemical characterization of turmeric eo by gas chromatography-mass spectrometry, the substantially antifungal activities of turmeric eo on the mycelial growth, spore germination and aflatoxin production were observed in a dose-dependent manne ... | 2017 | 27855875 |
| antiproliferative, protective and antioxidant effects of artichoke, dandelion, turmeric and rosemary extracts and their formulation. | artichoke, dandelion, turmeric extracts and rosemary essential oil are commonly used as ingredients in many herbal preparations to treat hepatic and gallbladder disorders. in the present work we compare the activity of each single extract with a commercial mixture for antiproliferative, antiradical and protective effects against induced oxidant stress effect. in abts and dpph tests, turmeric extract is the most active, followed by artichoke and dandelion. all samples exhibited antiproliferative ... | 2017 | 20646355 |
| condiments and contact dermatitis of the finger - tips. | patch tests were undertaken with 16 condiments in 4 groups of patients which included exposed patients, exposed controls, unexposed patients and unexposed controls. as the interpretation of the positive patch test reaction was similar in both the unexposed patients and unexposed controls, these two were combined into one (unexposed groups). positive reactions were obtained in a variable number of individuals in each of these groups but the tests were generally more frequently positive and more s ... | 2017 | 28145344 |
| patch tests in kum-kum dermatitis. | twenty patients having contact dermatitis on the forehead due to kum-kum were patch tested with the commercially available kum-kum,and also the turmeric powder used as such, as well as after alkalinisation potassium hydroxide to produce a reddish brown.colour. patch tests were positive in all the patients with the commercial kum-kum, but not with the turmeric powder in either form. | 2017 | 28150663 |