Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| curcumin for neuropsychiatric disorders: a review of in vitro, animal and human studies. | turmeric has been used in traditional medicine for centuries to treat a range of ailments. its primary active constituent curcumin, can influence an array of biological activities. many of these, such as its anti-inflammatory, antioxidant, neuroprotective, and monoaminergic effects are dysregulated in several neuropsychiatric disorders. in this systematic review, in vitro, animal, and human studies investigating the potential of curcumin as a treatment for neuropsychiatric disorders such as majo ... | 2017 | 28135888 |
| potential roles of chemical degradation in the biological activities of curcumin. | substantial pre-clinical and human studies have shown that curcumin, a dietary compound from turmeric, has a variety of health-promoting biological activities. a better understanding of the biochemical mechanisms for the health-promoting effects of curcumin could facilitate the development of effective strategies for disease prevention. recent studies have shown that in aqueous buffer, curcumin rapidly degrades and leads to formation of various degradation products. in this review, we summarized ... | 2017 | 28138677 |
| curcumin inhibits hypoxia-induced proliferation and invasion of mg-63 osteosarcoma cells via downregulating notch1. | curcumin is a biologically active ingredient abundantly present in the ground rhizomes of curcuma longa with a wide range of bioactive properties, including antitumor effects. hypoxia is a common characteristic of solid tumors, including osteosarcoma. however, whether curcumin has antitumor effects on osteosarcoma under hypoxic conditions, and its underlying molecular mechanisms, remain unclear. the present study demonstrated that the mg‑63 osteosarcoma cell line exhibited increased proliferatio ... | 2017 | 28138706 |
| protective effect of curcuma longa l. extract on ccl4-induced acute hepatic stress. | the curcuma longa l. (cll) rhizome has long been used to treat patients with hepatic dysfunction. cll is a member of the ginger family of spices that are widely used in china, india, and japan, and is a common spice, coloring, flavoring, and traditional medicine. this study was performed to evaluate the hepatoprotective activity of cll extract and its active component curcumin in an acute carbon tetrachloride (ccl4)-induced liver stress model. | 2017 | 28143589 |
| condiments and contact dermatitis of the finger - tips. | patch tests were undertaken with 16 condiments in 4 groups of patients which included exposed patients, exposed controls, unexposed patients and unexposed controls. as the interpretation of the positive patch test reaction was similar in both the unexposed patients and unexposed controls, these two were combined into one (unexposed groups). positive reactions were obtained in a variable number of individuals in each of these groups but the tests were generally more frequently positive and more s ... | 2017 | 28145344 |
| the antimalarial effect of curcumin is mediated by the inhibition of glycogen synthase kinase-3β. | curcumin, a bioactive compound in curcuma longa, exhibits various pharmacological activities, including antimalarial effects. in silico docking simulation studies suggest that curcumin possesses glycogen synthase kinase-3β (gsk3β)-inhibitory properties. the involvement of gsk3 in the antimalarial effects in vivo is yet to be demonstrated. in this study, we aimed to evaluate whether the antimalarial effects of curcumin involve phosphorylation of host gsk3β. intraperitoneal administration of curcu ... | 2017 | 28146408 |
| patch tests in kum-kum dermatitis. | twenty patients having contact dermatitis on the forehead due to kum-kum were patch tested with the commercially available kum-kum,and also the turmeric powder used as such, as well as after alkalinisation potassium hydroxide to produce a reddish brown.colour. patch tests were positive in all the patients with the commercial kum-kum, but not with the turmeric powder in either form. | 2017 | 28150663 |
| anthelmintic potential of thymoquinone and curcumin on fasciola gigantica. | fasciolosis an economically important global disease of ruminants in the temperate and tropical regions, caused by fasciola hepatica and f. gigantica, respectively, also poses a potential zoonotic threat. in india alone it causes huge losses to stakeholders. anthelmintics including triclabendazole have been used to control this menace but the emerging resistance against the available compounds necessitates identification of novel and alternative therapeutic measures involving plant derived natur ... | 2017 | 28152102 |
| drug target identification and elucidation of natural inhibitors for bordetella petrii: an in silico study. | environmental microbes like bordetella petrii has been established as a causative agent for various infectious diseases in human. again, development of drug resistance in b. petrii challenged to combat against the infection. identification of potential drug target and proposing a novel lead compound against the pathogen has a great aid and value. in this study, bioinformatics tools and technology have been applied to suggest a potential drug target by screening the proteome information of b. pet ... | 2016 | 28154518 |
| anti-apoptotic effects of curcuma longa l. extract and its curcuminoids against blue light-induced cytotoxicity in a2e-laden human retinal pigment epithelial cells. | the purpose of the study was to investigate the protective effect of the curcuma longa l. extract (cle) and its curcuminoids against blue light-induced cytotoxicity in human retinal pigment epithelial (rpe) cells laded with a2e. a2e has been concerned in age-related macular degeneration (amd). | 2017 | 28155996 |
| curcumin decreases malignant characteristics of glioblastoma stem cells via induction of reactive oxygen species. | glioblastoma multiforme (gbm) is the most common and lethal form of primary brain tumor in adults. following standard treatment of surgery, radiation and chemotherapy, patients are expected to survive 12-14 months. theorized cause of disease recurrence in these patients is tumor cell repopulation through the proliferation of treatment-resistant cancer stem cells. current research has revealed curcumin, the principal ingredient in turmeric, can modulate multiple signaling pathways important for c ... | 2017 | 28160777 |
| inhibition of cell survival by curcumin is associated with downregulation of cell division cycle 20 (cdc20) in pancreatic cancer cells. | pancreatic cancer is one of the most aggressive human tumors in the united states. curcumin, a polyphenol derived from the curcuma longa plant, has been reported to exert its antitumor activity in pancreatic cancer. however, the molecular mechanisms of curcumin-mediated tumor suppressive function have not been fully elucidated. in the current study, we explore whether curcumin exhibits its anti-cancer function through inhibition of oncoprotein cell division cycle 20 (cdc20) in pancreatic cancer ... | 2017 | 28165402 |
| investigation on curcumin nanocomposite for wound dressing. | curcuma longa (turmeric) has a long history of use in medicine as a treatment for inflammatory conditions. the primary active constituent of turmeric and the one responsible for its vibrant yellow color is curcumin. curcumin is used for treatment of wound and inflammation. it had antimicrobial and antioxidant property. it has low intrinsic toxicity and magnificent properties like with comparatively lesser side-effects. cotton cloth is one of the most successful wound dressings which utilize the ... | 2017 | 28167107 |
| curcumin and treatment of melanoma: the potential role of micrornas. | melanoma is the most aggressive type of skin cancer and is characterized by poor prognosis in its advanced stages because treatments are poorly effective and burdened with severe adverse effects. micrornas (mirnas) are small non-coding rnas that are implicated in several cellular processes; they are categorized as oncogenic and tumor suppressor mirnas. several mirnas are implicated in the pathogenesis and progression of melanoma, such as the tumor suppressor mir-let7b that targets cyclin d and r ... | 2017 | 28167449 |
| curcumin alters neural plasticity and viability of intact hippocampal circuits and attenuates behavioral despair and cox-2 expression in chronically stressed rats. | curcumin is a major diarylheptanoid component of curcuma longa with traditional usage for anxiety and depression. it has been known for the anti-inflammatory, antistress, and neurotropic effects. here we examined curcumin effect in neural plasticity and cell viability. 60-channel multielectrode array was applied on organotypic hippocampal slice cultures (ohscs) to monitor the effect of 10 μm curcumin in long-term depression (ltd) through low-frequency stimulation (lfs) to the schaffer collateral ... | 2017 | 28167853 |
| curcumin protects neuronal cells against status-epilepticus-induced hippocampal damage through induction of autophagy and inhibition of necroptosis. | status epilepticus, the most severe form of epilepsy, is characterized by progressive functional and structural damage in the hippocampus, ultimately leading to the development and clinical appearance of spontaneous, recurrent seizures. although the pathogenesis underlying epileptogenesis processes remains unclear, a substantial body of evidence has shown that status epilepticus acts as an important initial factor in triggering epileptogenesis. notably, besides classical cell death mechanisms su ... | 2016 | 28177687 |
| the effects of curcuminoids on musculoskeletal pain: a systematic review. | western countries are increasingly using complementary and alternative medicine (cam) to assist with relieving ailments. turmeric, from the ginger family zingiberaceae, has a history of use for medicinal purposes. the polyphenols found in turmeric (curcuminoids) have demonstrated anti-inflammatory and pain relieving properties. with the use of cams increasing, it is important for the effectiveness of curcuminoids to be established. | 2017 | 28178024 |
| a placebo-controlled double-blinded randomized pilot study of combination phytotherapy in biochemically recurrent prostate cancer. | men with biochemical recurrence of prostate cancer following local therapies often use natural supplements in an attempt to delay metastases and/or avoid the need for more aggressive treatments with undesirable side-effects. while there is a growing body of research into phytotherapeutic agents in this cohort, with some promising results, as yet no definitive recommendations can be made. this pilot study was undertaken to assess the feasibility of a fully-powered study to examine the effects of ... | 2017 | 28181675 |
| cytotoxic and apoptotic effects of the combination of palladium (ii) 5,5-diethylbarbiturate complex with bis(2-pyridylmethyl)amine and curcumin on non small lung cancer cell lines. | metal-based chemotherapeutics such as cisplatin are widely used treatment of lung cancer which is the major cause of cancer-related mortality worldwide. recent studies demonstrated that novel metal-based compounds have strong cytotoxic activity in a similar way as cisplatin. therefore, metal-based compounds have been synthesized and investigated in order to determine their cytotoxic activities. it has been also reported curcumin, which has been derived from turmeric plant, has powerful cytotoxic ... | 2017 | 28187956 |
| effects of curcumin on hdl functionality. | curcumin, a bioactive polyphenol, is a yellow pigment of the curcuma longa (turmeric) plant. curcumin has many pharmacologic effects including antioxidant, anti-carcinogenic, anti-obesity, anti-angiogenic and anti-inflammatory properties. recently, it has been found that curcumin affects lipid metabolism, and subsequently, may alleviate hyperlipidemia and atherosclerosis. plasma hdl cholesterol (hdl-c) is an independent negative risk predictor of cardiovascular disease (cvd). however, numerous c ... | 2017 | 28192240 |
| dual functional mesoporous silicon nanoparticles enhance the radiosensitivity of vpa in glioblastoma. | radiotherapy is a critical strategy and standard adjuvant approach to glioblastoma treatment. one of the major challenges facing radiotherapy is to minimize radiation damage to normal tissue without compromising therapeutic effects on cancer cells. various agents and numerous approaches have been developed to improve the therapeutic index of radiotherapy. among them, radiosensitizers have attracted much attention because they selectively increase susceptibility of cancer cells to radiation and t ... | 2017 | 28193559 |
| curcumin attenuates titanium particle-induced inflammation by regulating macrophage polarization in vitro and in vivo. | periprosthetic inflammatory osteolysis and subsequent aseptic loosening are commonly observed in total joint arthroplasty. other than revision surgery, few approved treatments are available for this complication. wear particle-induced inflammation and macrophage polarization state play critical roles in periprosthetic osteolysis. we investigated the effects of curcumin, a polyphenol extracted from curcuma longa, on titanium (ti) particle-induced inflammation and macrophage polarization in vitro ... | 2017 | 28197150 |
| effects of curcumin on serum vitamin e concentrations in individuals with metabolic syndrome. | vitamin e is an important lipid-soluble antioxidant. the aim of the present study was to investigate the effect of curcumin on serum vitamin e levels in subjects with metabolic syndrome (mets). a total of 120 subjects aged 18-65 years old with mets were recruited in this study according to the international diabetic federation criteria. included subjects were randomized into three groups: subjects receiving lecithinized curcumin (1 g/day equivalent to 200-mg pure curcumin per day) for a period o ... | 2017 | 28198120 |
| analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects. | the optimal health benefits of curcumin are limited by its low solubility in water and corresponding poor intestinal absorption. cyclodextrins (cd) can form inclusion complexes on a molecular basis with lipophilic compounds, thereby improving aqueous solubility, dispersibility, and absorption. in this study, we investigated the bioavailability of a new γ-cyclodextrin curcumin formulation (cw8). this formulation was compared to a standardized unformulated curcumin extract (stdc) and two commercia ... | 2017 | 28204880 |
| efficacy of specific plant products on microorganisms causing dental caries. | dental caries and periodontal diseases are the most common oral diseases seen globally, both in developed and developing countries. oral microorganisms that is gram positive and gram negative bacteria are known to be involved in causation of these diseases. nowadays commercially available dentrifices and mouth rinses are known to contain ingredients that can alter the oral microbial flora and have undesirable side effects such as vomiting, diarrhoea, disarrangement of oral, intestinal flora and ... | 2016 | 28209019 |
| pharmacogenomic characterization and isobologram analysis of the combination of ascorbic acid and curcumin-two main metabolites of curcuma longa-in cancer cells. | curcuma longa has long been used in china and india as anti-inflammatory agent to treat a wide variety of conditions and also as a spice for varied curry preparations. the chemoprofile of the curcuma species exhibits the presence of varied phytochemicals with curcumin being present in all three species but aa only being shown in c. longa. this study explored the effect of a curcumin/aa combination on human cancer cell lines. the curcumin/aa combination was assessed by isobologram analysis using ... | 2017 | 28210221 |
| curcumin-functionalized silk biomaterials for anti-aging utility. | curcumin is a natural antioxidant that is isolated from turmeric (curcuma longa) and exhibits strong free radical scavenging activity, thus functional for anti-aging. however, poor stability and low solubility of curcumin in aqueous conditions limit its biomedical applications. previous studies have shown that the anti-oxidation activity of curcumin embedded in silk fibroin films could be well preserved, resulting in the promoted adipogenesis from human mesenchymal stem cells (hmscs) cultured on ... | 2017 | 28214625 |
| anticancer potential of nutraceutical formulations in mnu-induced mammary cancer in sprague dawley rats. | nutraceuticals help in combating some of the major health problems of the century including cancer, and 'nutraceutical formulations' have led to the new era of medicine and health. | 2017 | 28216882 |
| novel insight from computational virtual screening depict the binding potential of selected phytotherapeutics against probable drug targets of clostridium difficile. | this study explores computational screening and molecular docking approaches to screen novel herbal therapeutics against probable drug targets of clostridium difficile. the essential genes were predicted by comparative genome analysis of c. difficile and best homologous organisms using blast search at database of essential genes (deg). the functions of these genes in various metabolic pathways were predicted and some of these genes were considered as potential targets. three major proteins were ... | 2017 | 28217823 |
| a bioprocessed polysaccharide from lentinus edodes mycelia cultures with turmeric protects chicks from a lethal challenge of salmonella gallinarum. | our previous studies demonstrated that a bioprocessed polysaccharide (bpp) isolated from lentinus edodes mushroom mycelia cultures supplemented with black rice bran can protect mice against salmonella lipopolysaccharide-induced endotoxemia and reduce the mortality from salmonella typhimurium infection through upregulated t-helper 1 immunity. here, we report that a bpp from l. edodes mushroom mycelia liquid cultures supplemented with turmeric (referred to as bpp-turmeric) alters chicken macrophag ... | 2017 | 28221973 |
| curcumin inhibits cancer progression through regulating expression of micrornas. | curcumin, a major yellow pigment and spice in turmeric and curry, is a powerful anti-cancer agent. the anti-tumor activities of curcumin include inhibition of tumor proliferation, angiogenesis, invasion and metastasis, induction of tumor apoptosis, increase of chemotherapy sensitivity, and regulation of cell cycle and cancer stem cell, indicating that curcumin maybe a strong therapeutic potential through modulating various cancer progression. it has been reported that micrornas as small noncodin ... | 2017 | 28222667 |
| curcumin attenuates surgery-induced cognitive dysfunction in aged mice. | post-operative cognitive dysfunction (pocd) is associated with elderly patients undergoing surgery. however, pharmacological treatments for pocd are limited. in this study, we found that curcumin, an active compound derived from curcuma longa, ameliorated the cognitive dysfunction following abdominal surgery in aged mice. further, curcumin prevented surgery-induced anti-oxidant enzyme activity. curcumin also increased brain-derived neurotrophic factor (bdnf)-positive area and expression of pakt ... | 2017 | 28224377 |
| claudin-3 and occludin content in the glands of colonic mucosa devoid from fecal stream submitted to topical intervention with oil extract of curcuma longa. | to evaluate the inflammatory intensity and measure the tissue content of the proteins claudin-3 and occludin in the colonic mucosa without fecal stream submit to intervention with curcumin. | 2017 | 28225919 |
| evaluation of turmeric powder adulterated with metanil yellow using ft-raman and ft-ir spectroscopy. | turmeric powder (curcuma longa l.) is valued both for its medicinal properties and for its popular culinary use, such as being a component in curry powder. due to its high demand in international trade, turmeric powder has been subject to economically driven, hazardous chemical adulteration. this study utilized fourier transform-raman (ft-raman) and fourier transform-infra red (ft-ir) spectroscopy as separate but complementary methods for detecting metanil yellow adulteration of turmeric powder. ... | 2016 | 28231130 |
| clinical use of curcumin in depression: a meta-analysis. | there is growing interest in the use of curcumin, a plant polyphenol with potent anti-inflammatory, anti-oxidant, and neuroprotective properties, as a novel antidepressant. clinical trials have yielded conflicting conclusions pertaining to its effectiveness in depression. a meta-analysis of the topic, which has not been done until now, is therefore necessary to summarize current evidence and generate hypotheses for further research. | 2017 | 28236605 |
| synthetic curcumin derivative dk1 possessed g2/m arrest and induced apoptosis through accumulation of intracellular ros in mcf-7 breast cancer cells. | curcumin is a lead compound of the rhizomes of curcuma longa and possess a broad range of pharmacological activities. chemically, curcumin is 1,3-dicarbonyl class of compound, which exhibits keto-enol tautomerism. despite of its strong biological properties, curcumin has yet been recommended as a therapeutic agent because of its poor bioavailability. | 2017 | 28239299 |
| possible role of common spices as a preventive and therapeutic agent for alzheimer's disease. | for centuries, spices have been consumed as food additives or medicinal agents. however, there is increasing evidence indicating the plant-based foods in regular diet may lower the risk of neurodegenerative diseases including alzheimer disease. spices, as one of the most commonly used plant-based food additives may provide more than just flavors, but as agents that may prevent or even halt neurodegenerative processes associated with aging. in this article, we review the role and application of f ... | 2017 | 28250905 |
| microrna-7 functions as a tumor-suppressor gene by regulating ilf2 in pancreatic carcinoma. | interleukin enhancer binding factor 2 (ilf2) has been found to be markedly upregulated in pancreatic carcinoma and is involved in the pathogenesis of pancreatic carcinoma. thus, ilf2 may be a potential target for therapy. yet, the regulatory mechanisms of ilf2 in pancreatic carcinoma remain largely elusive. in the present study, we demonstrated that ilf2 functioned as an oncogene and regulated epithelial-mesenchymal transition (emt)-associated genes in pancreatic carcinoma panc-1 cells. microrna ... | 2017 | 28259961 |
| curcumin, a potential therapeutic candidate for anterior segment eye diseases: a review. | curcumin, the major curcuminoid of the turmeric, has been extensively used in many countries since ancient time for preventing and/or treating a multitude of diseases. this review is to illustrate the researches on the properties of curcumin and its potential therapeutic efficacy in major anterior segment eye diseases. the bio-medical potential of curcumin is restricted because of its low solubility and digestive bioavailability. this review will discuss promising research in improving curcumin ... | 2017 | 28261099 |
| new curcumin-loaded chitosan nanocapsules: in vivo evaluation. | the medicinal applications of curcumin, the major component of curcuma longa, are limited by its poor solubility and low oral bioavailability. in order to overcome this limitation, a method to produce nanocapsules of chitosan loaded with curcumin was developed. three different molecular weight and deacetylation degree chitosan polymers were used in the formulation in order to prepare curcumin-loaded nanocapsules (mass ratio 1 : 1.4). the best results were achieved using chitosan-bi with a molecu ... | 2017 | 28264204 |
| the effect of curcumin on bladder tumor in rat model. | bladder cancer is the most commonly malignant tumor in the urogenital tract, only next to prostate cancer with a higher incidence in china. curcumin is the major component of curcuma longa and has multiple biological effects including anti-tumor. this study aimed to investigate the effect of curcumin on bladder cancer. | 2017 | 28272691 |
| spectrophotometric evaluation of colour stability of nano hybrid composite resin in commonly used food colourants in asian countries. | there is growing interest in colour stability of aesthetic restorations. so far few studies have been reported. | 2017 | 28274047 |
| production of curcuminoids in engineered escherichia coli. | curcumin, a hydrophobic polyphenol derived from the rhizome of the herb curcuma longa, possesses diverse pharmacological properties including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activity. two curcuminoids (dicinnamoylmethane and bisdemethoxycurcumin) were synthesized from glucose in escherichia coli. pal (phenylalanine ammonia lyase) or tal (tyrosine ammonia lyase), along with os4cl (p-coumaroyl-coa ligase) and cus (curcumin synthase), were introduced in to e. co ... | 2017 | 28274102 |
| oxidative metabolism of curcumin-glucuronide by peroxidases and isolated human leukocytes. | conjugation with glucuronic acid is a prevalent metabolic pathway of orally administrated curcumin, the bioactive diphenol of the spice turmeric. the major in vitro degradation reaction of curcumin is autoxidative transformation resulting in oxygenation and cyclization of the heptadienedione chain to form cyclopentadione derivatives. here we show that curcumin-glucuronide is much more stable than curcumin, degrading about two orders of magnitude slower. horseradish peroxidase-catalyzed oxidation ... | 2017 | 28274615 |
| curcumin as a potential protective compound against cardiac diseases. | curcumin, which was first used 3000 years ago as an anti-inflammatory agent, is a well-known bioactive compound derived from the active ingredient of turmeric (curcuma longa). previous research has demonstrated that curcumin has immense therapeutic potential in a variety of diseases via anti-oxidative, anti-apoptotic, and anti-inflammatory pathways. cardiac diseases are the leading cause of mortality worldwide and cause considerable harm to human beings. numerous studies have suggested that curc ... | 2017 | 28274852 |
| in situ development and application of natural coatings on non-absorbable sutures to reduce incision site infections. | the purpose of the study was the development of a suture line that has antibacterial properties and reduces the chance of wound infection thus facilitating the healing process. | 2017 | 28277992 |
| antioxidant supplements and gastrointestinal diseases: a critical appraisal. | the gastrointestinal tract digests and absorbs dietary nutrients; protects the body against physical and chemical damage from contents in its lumen; provides immunity against external antigens and keeps an optimum environment for the gut microbiota. these functions cannot be performed normally in several diseases of which the following are discussed here: irritable bowel syndrome, inflammatory bowel disease which includes crohn's disease and ulcerative colitis. because these diseases are associa ... | 2017 | 28278495 |
| a glycyrrhetinic acid-modified curcumin supramolecular hydrogel for liver tumor targeting therapy. | curcumin (cur), a phenolic anti-oxidant compound obtained from curcuma longa plant, possesses a variety of therapeutic properties. however, it is suffered from its low water solubility and low bioavailability property, which seriously restricts its clinical application. in this study, we developed a glycyrrhetinic acid (ga) modified curcumin supramolecular pro-gelator (ga-cur) and a control compound nap-cur by replacing ga with the naphthylacetic acid (nap). both compounds showed good water solu ... | 2017 | 28281678 |
| bisdemethoxycurcumin enhances x-ray-induced apoptosis possibly through p53/bcl-2 pathway. | bisdemethoxycurcumin (bdmc), which is isolated from the rhizomes of curcuma longa, has anti-inflammatory and anti-carcinogenic activities. here we found that bdmc enhanced x-ray-induced apoptosis in human t-cell leukemia molt-4 cells. knockdown of p53 significantly attenuated the radiosensitizing effect of bdmc. however, bdmc did not enhance x-ray-mediated activation of the p53 signaling pathway via p53's transactivation or mitochondrial translocation. on the other hand, bdmc promoted the x-ray- ... | 2017 | 28283087 |
| comparison of antioxidant, anticholinesterase, and antidiabetic activities of three curcuminoids isolated from curcuma longa l. | antioxidant, anticholinesterase and antidiabetic activities of three curcuminoids isolated from the curcuma longa were simultaneously tested and compared in this study. the highest antioxidant power was detected for curcumin with the applied methods. the drug potentials of curcuminoids for alzheimer's disease were controlled. bisdemethoxycurcumin (bdmc) showed substantial inhibitory activity. the activity of demethoxycurcumin (dmc) followed bdmc, whereas curcumin showed very little acetylcholine ... | 2017 | 28287280 |
| antiparasitic efficacy of curcumin from curcuma longa against ichthyophthirius multifiliis in grass carp. | ichthyophthirius multifiliis is a ciliated parasite that elicits great economic losses in aquaculture. in the present study, a polyphenol compound, curcumin, was obtained from the rhizome of curcuma longa by bioassay-guided isolation based on the efficacy of anti-i. multifiliis theronts. anti-i. multifiliis efficacy of curcumin was evaluated in vitro and in vivo. curcumin resulted in 100% mortality of i. multifiliis theronts at a concentration of 1mg/l within 21.7±1.2min and killed all tomonts a ... | 2017 | 28288756 |
| curcumin inhibits lipopolysaccharide (lps)-induced endotoxemia and airway inflammation through modulation of sequential release of inflammatory mediators (tnf-α and tgf-β1) in murine model. | curcumin (diferuloylmethane), a major component of turmeric is well known for its anti-inflammatory potential. present study investigates sequential release of inflammatory mediators post lps challenge (10 mg/kg,i.p.) causing lung inflammation and its modulation by curcumin through different routes (20 mg/kg, i.p and 10 mg/kg, i.n.) in murine model. dexamethasone (1 mg/kg, i.p) was used as standard drug. | 2017 | 28289922 |
| attenuation of oxidative stress-induced osteoblast apoptosis by curcumin is associated with preservation of mitochondrial functions and increased akt-gsk3β signaling. | osteoblast apoptosis induced by oxidative stress plays a crucial role in the development and progression of osteoporosis. curcumin, a natural antioxidant isolated from curcuma longa, has highly protective effects against osteoporosis. however, the effects of curcumin on oxidative stress-induced osteoblast apoptosis remain unclear. this study aimed to explore the effect of curcumin on hydrogen peroxide (h2o2) induced osteoblast apoptosis and the underlying mechanisms. | 2017 | 28291961 |
| the effect of hydro-ethanolic extract of curcuma longa rhizome and curcumin on total and differential wbc and serum oxidant, antioxidant biomarkers in rat model of asthma. | the effects of curcuma longa (c. longa) and curcumin on total and differential wbc count and oxidant, antioxidant biomarkers, in rat model of asthma were evaluated. | 2017 | 28293392 |
| pharmacological effects of turmeric on learning, memory and expression of muscarinic receptor genes (m1, m3 and m5) in stress-induced mouse model. | stress is involved in memory impairment by multiple mechanisms including activation of hypothalamic-pituitary axis, which in turn activates release of corticosterone in blood. cholinergic system blockade by muscarinic antagonist like scopolamine, also impairs memory. | 2017 | 28302036 |
| purity evaluation of curcuminoids in the turmeric extract obtained by accelerated solvent extraction. | curcuminoids, the active principle of <i>curcuma longa </i>l, is one of the most researched subjects worldwide for its broad-spectrum biological activities. being traditionally known for their anticancer properties and issues related to bioavailability, the curcuminoids, including diferuloylmethane (curcumin), have gained special attention. thus, the current study focused on the purity profiling of curcuminoids when extracted by accelerated solvent extraction, which was run with turmeric rhizome ... | 2017 | 28303780 |
| turmeric extract inhibits apoptosis of hippocampal neurons of trimethyltin-exposed rats. | the aim of the present study was to reveal the possible antiapoptotic effect of turmeric (curcuma longa linn.) on the hippocampal neurons of rats exposed to trimethyltin (tmt). | 2017 | 28319408 |
| identification of two strains of paenibacillus sp. as indole 3 acetic acid-producing rhizome-associated endophytic bacteria from curcuma longa. | curcuma longa is well known for its use as spice and medicine. the remarkable feature of the plant is the presence of rhizome, which provides an interesting habitat for association by various groups of bacteria. some of these associated endophytic bacteria can have growth-promoting effects. in the current study, two species of endophytic paenibacillus has been identified from the rhizome as indole 3 acetic acid producers. these isolates can thus have potential growth-regulating effect in rhizome ... | 2013 | 28324371 |
| isolation and characterization of bacterial endophytes of curcuma longa l. | fourteen endophytic bacterial isolates were isolated from the rhizome of curcuma longa l. were characterized on the basis of morphology, biochemical characteristics and 16s rrna gene sequence analysis. the isolates were identified to six strains namely bacillus cereus (ecl1), bacillus thuringiensis (ecl2), bacillus sp. (ecl3), bacillus pumilis (ecl4), pseudomonas putida (ecl5), and clavibacter michiganensis (ecl6). all the strains produced iaa and solubilized phosphate and only two strains produ ... | 2016 | 28330130 |
| the effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (erα) in breast cancer cells. | curcumin (cur) is a compound that has antibacterial, antiviral, anti-inflammatory, and anticancer properties. in this study, we have analyzed the effects of cur on the expression of erα and p53 in the presence of hormones and anti-hormones in breast cancer cells. cells were cultured in a medium containing charcoal-stripped fetal bovine serum to deplete any endogenous steroids and treated with cur at varying concentrations or in combination with hormones and anti-hormones. protein analysis reveal ... | 2017 | 28331366 |
| curcuma longa linn. extract and curcumin protect cyp 2e1 enzymatic activity against mercuric chloride-induced hepatotoxicity and oxidative stress: a protective approach. | the present investigation has been conducted to evaluate the therapeutic potential of curcuma longa (200mgkg(-1), po) and curcumin (80mgkg(-1), po) for their hepatoprotective efficacy against mercuric chloride (hgcl2: 12μmolkg(-1), ip; once only) hepatotoxicity. the hgcl2 administration altered various biochemical parameters, including transaminases, alkaline phosphatase, lactate dehydrogenase, bilirubin, gamma-glutamyl transferase, triglycerides and cholesterol contents with a concomitant decli ... | 2017 | 28336172 |
| curcumin inhibits zika and chikungunya virus infection by inhibiting cell binding. | several compounds extracted from spices and herbs exhibit antiviral effects in vitro, suggesting potential pharmacological uses. curcumin, a component of turmeric, has been used as a food additive and herbal supplement due to its potential medicinal properties. previously, curcumin exhibited antiviral properties against several viruses, including dengue virus and hepatitis c virus, among others. here, we describe the antiviral effect of curcumin on zika and chikungunya viruses, two mosquito-born ... | 2017 | 28343845 |
| formation of turmeric-based thin films: universal, transparent coatings. | curry stains on clothes and dishes in daily life inspired us to investigate the potential use of turmeric powder, the major ingredient in curry, as a universal coating material. after condition optimization, the coating solution was made by boiling and filtering a turmeric slurry, and the coating was formed at ph 3, leading to the formation of ultrathin, transparent films. various inorganic and polymeric substrates were successfully coated with turmeric-based materials, including gold, tio2, sio ... | 2017 | 28345932 |
| molecular mechanisms of cholangiocarcinoma cell inhibition by medicinal plants. | cholangiocarcinoma (cca) is one of the most common causes of cancer-associated mortality in thailand. certain phytochemicals have been demonstrated to modulate apoptotic signaling pathways, which may be targeted for the prevention and treatment of cancer. therefore, the aim of the present study was to investigate the effect of specific medicinal plants on the inhibition of cca cell proliferation, and to identify the molecular mechanisms underlying this. a wst-1 cell proliferation assay was perfo ... | 2017 | 28356985 |
| ground turmeric as a source of lead exposure in the united states. | 2017 | 28358991 | |
| extraction, processing, and storage effects on curcuminoids and oleoresin yields from curcuma longa l. grown in jamaica. | 2017 | 28362094 | |
| antimicrobial and physical properties of chitosan films incorporated with turmeric extract. | in this study, the effects of turmeric extract incorporation on the antibacterial and physical properties of the chitosan films were evaluated. turmeric containing chitosan-based film was produced with casting procedure and cross-linked with sodium sulfate. mechanical, optical, thermal properties, and water vapor permeability of the films were studied. the addition of turmeric to chitosan film significantly increased the tensile strength of the film and improved the ultraviolet-visible light bar ... | 2017 | 28366856 |
| continuous production of aqueous suspensions of ultra-fine particles of curcumin using ultrasonically driven mixing device. | developing drug formulations for poorly water soluble drugs is a major challenge for pharmaceutical industries as the poor water solubility limits bioavailability of these drugs. production of nanoparticles/microparticles of these drugs is one of the ways to improve dissolution rates by increasing interfacial area for dissolution. curcumin, a compound obtained from the rhizome of curcuma longa (turmeric roots), is a pharmaceutically viable molecule. however, poor aqueous solubility limits its th ... | 2017 | 28368746 |
| comparative evaluation of clinical and radiographic success of formocresol, propolis, turmeric gel, and calcium hydroxide on pulpotomized primary molars: a preliminary study. | despite various advents in technology, the present era marks a shift to phytotherapeutics and alternative modalities to conventional endodontic treatments. newer endodontic modalities have been developed inculcating the ancient system of medicine. the present study was done to compare and evaluate the clinical pulp response and radiographic signs after pulpotomy in four groups of primary molar teeth treated with formocresol (control), propolis extract, turmeric gel, and calcium hydroxide respect ... | 2017 | 28377649 |
| clinical and radiological evaluation of turmeric powder as a pulpotomy medicament in primary teeth: an in vivo study. | many plants with biological and antimicrobiological properties have been studied since there has been a relevant increase in the incidence of antibiotic overuse and misuse. in dentistry, phytomedicines have been used as anti-inflammatory, antibiotic, analgesic, and sedative agents. turmeric is used extensively in foods for its flavor and color, as well as having a long tradition of use in the chinese and ayurvedic systems of medicine, particularly as an anti-inflammatory and for the treatment of ... | 2017 | 28377653 |
| norfloxacin and metronidazole topical formulations for effective treatment of bacterial infections and burn wounds. | our various previous findings have shown the suitability of norfloxacin in the treatment of bacterial infections and burn wounds in alone as well as in combination with curcuma longa in various topical (ointments, gels, and creams) and transdermal drug delivery systems. | 2016 | 28386462 |
| response to "commentary on 'clinicobiochemical evaluation of turmeric with black pepper and nigella sativa in management of oral submucous fibrosis-a double-blind, randomized preliminary study'". | 2017 | 28392231 | |
| biocontrol potentials of antimicrobial peptide producing bacillus species: multifaceted antagonists for the management of stem rot of carnation caused by sclerotinia sclerotiorum. | bacillus species are widely exploited as biocontrol agents because of their efficiency in impeding various plant pathogens with multifaceted approach. in this study, bacillus species were isolated from rhizosphere of various plants viz., carnations, cotton, turmeric, and bananas in tamil nadu state of india. their potential to control the mycelial growth of sclerotinia sclerotiorum was assessed in vitro by dual plate and partition plate techniques. b. amyloliquefaciens strain vb7 was much effect ... | 2017 | 28392780 |
| an overview of structure-activity relationship studies of curcumin analogs as antioxidant and anti-inflammatory agents. | curcumin, extracted mainly from curcuma longa rhizomes, has been reported to possess potent anti-inflammatory and anti-oxidant activities. although safe at higher doses and exhibiting multiple biological activities, curcumin still has the problem of poor bioavailability which has been an attractive area of research over the last few years. a number of efforts have been made by modifying structural features of curcumin. this review highlights the structurally modified and more stable newly synthe ... | 2017 | 28394628 |
| essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis. | turmeric has been used as a medicinal herb for thousands of years for treatment of various disorders. although curcumin is the most studied active constituents of turmeric, accumulating evidence suggests that other components of turmeric have additional anti-inflammatory and anti-tumorigenic properties. herein, we investigated anti-inflammatory efficacy and associated gene expression alterations of a specific, curcumin preparation containing essential turmeric oils (eto-curcumin) in comparison t ... | 2017 | 28400554 |
| curcuminoid demethylation as an alternative metabolism by human intestinal microbiota. | curcumin and other curcuminoids from curcuma longa are important bioactive compounds exhibiting various pharmacological activities. in addition to the known reductive metabolism of curcuminoids, an alternative biotransformation of curcuminoids by human gut microbiota is reported herein. a curcuminoid mixture, composed of curcumin (1), demethoxycurcumin (2), and bisdemethoxycurcumin (3) was metabolized by the human intestinal bacterium blautia sp. mrg-pmf1. 1 and 2 were converted to new metabolit ... | 2017 | 28401758 |