Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| clinicobiochemical evaluation of turmeric with black pepper and nigella sativa in management of oral submucous fibrosis-a double-blind, randomized preliminary study. | to investigate the effectiveness of turmeric with black pepper and nigella sativa in oral submucous fibrosis (osmf). | 2016 | 27720650 |
| efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: a randomised, double-blind, placebo-controlled study. | several studies have supported the antidepressant effects of curcumin (from the spice turmeric) and saffron for people with major depressive disorder. however, these studies have been hampered by poor designs, small sample sizes, short treatment duration, and similar intervention dosages. furthermore, the antidepressant effects of combined curcumin and saffron administration are unknown. | 2017 | 27723543 |
| in silico approaches and proportional odds model towards identifying selective adam17 inhibitors from anti-inflammatory natural molecules. | adam metallopeptidase domain 17 (adam17) is an attractive target for the development of new anti-inflammatory drugs. we aimed to identify selective inhibitors of adam17 against matrix metalloproteinase enzymes (mmp-1, mmp-2, mmp-3, mmp-7, mmp-8, mmp-9, mmp-13, and mmp-16) which have substantial structural similarity. target proteins were docked with 29 anti-inflammatory natural molecule ligands and a known selective inhibitor ik682. the ligands were screened based on lipinski rules, interaction ... | 2016 | 27723561 |
| identification of suitable natural inhibitor against influenza a (h1n1) neuraminidase protein by molecular docking. | the influenza a (h1n1) virus, also known as swine flu is a leading cause of morbidity and mortality since 2009. there is a need to explore novel anti-viral drugs for overcoming the epidemics. traditionally, different plant extracts of garlic, ginger, kalmegh, ajwain, green tea, turmeric, menthe, tulsi, etc. have been used as hopeful source of prevention and treatment of human influenza. the h1n1 virus contains an important glycoprotein, known as neuraminidase (na) that is mainly responsible for ... | 2016 | 27729839 |
| antitumor activity of curcumin is involved in down-regulation of yap/taz expression in pancreatic cancer cells. | pancreatic cancer (pc) is one of the most aggressive human malignancies worldwide and is the fourth leading cause of cancer-related deaths. curcumin (diferuloylmethane) is a polyphenol derived from the curcuma longa plant. certain studies have demonstrated that curcumin exerts its anti-tumor function in a variety of human cancers including pc, via targeting multiple therapeutically important cancer signaling pathways. however, the detailed molecular mechanisms are not fully understood. two trans ... | 2016 | 27738325 |
| curcumin as a natural regulator of monocyte chemoattractant protein-1. | monocyte chemoattractant/chemotactic protein-1 (mcp-1), a member of the cc chemokine family, is one of the key chemokines that regulate migration and tissue infiltration of monocytes/macrophages. its role in the pathophysiology of several inflammatory diseases has been widely recognized, thus making mcp-1 a possible target for anti-inflammatory treatments. curcumin (diferuloylmethane) is a natural polyphenol derived from the rhizomes of curcuma longa l. (turmeric). anti-inflammatory action under ... | 2017 | 27743775 |
| yellow feet in a patient with breast and thyroid carcinoma, due to oral intake of turmeric. | yellow discoloration of the skin may be caused by several etiologies, including jaundice, hypervitaminosis, drug reaction or chemical exposure. herein we describe a 68-year-old woman with a history of breast and thyroid carcinoma, presenting with a yellow discoloration of her soles, after ingestion of one capsule a day of turmeric root extract (bluebonnet turmeric root, 500 mg, vcap), taken for its anti-cancer properties, for 4 months. after drug cessation, the yellow hue disappeared completely. ... | 2015 | 27747716 |
| ostwald ripening stability of curcumin-loaded mct nanoemulsion: influence of various emulsifiers. | curcumin is a flavonoid found in the rhizome of the turmeric plant (curcuma longa l.) and has recently attracted interest because it has numerous biological functions and therapeutic properties. in the present study, we attempted to incorporate curcumin into medium-chain triglyceride (mct) nanoemulsions (0.15 wt% curcumin, 10 wt% mct oil, and 10 wt% emulsifiers) with various emulsifiers [polyoxyethylene (20) sorbitan monolaurate (tween-20), sorbitan monooleate (sm), and soy lecithin (sl)]. the p ... | 2016 | 27752506 |
| curcuma longa extract reduces inflammatory and oxidative stress biomarkers in osteoarthritis of knee: a four-month, double-blind, randomized, placebo-controlled trial. | curcuma longa l. (cl), an indian herb, has been used to treat many disorders because of its wide spectrum of pharmacological activities. it has been shown to exhibit anti-oxidant and anti-inflammatory properties, and is being used as herbal remedy since ancient times. osteoarthritis of knee (koa) is a chronic painful disorder in which prolong use of non-steroidal anti-inflammatory drugs (nsaids) or steroids may result into many serious side effects; hence, there is a need to develop herbal drugs ... | 2016 | 27761693 |
| copper supplementation amplifies the anti-tumor effect of curcumin in oral cancer cells. | oral cancer is the sixth most common cancer worldwide and 90% of oral malignancies are caused by oral squamous cell carcinoma (oscc). curcumin, a phytocompound derived from turmeric (curcuma longa) was observed to have anti-cancer activity which can be developed as an alternative treatment option for oscc. however, oscc cells with various clinical-pathological features respond differentially to curcumin treatment. | 2016 | 27765374 |
| development of prediction model and experimental validation in predicting the curcumin content of turmeric (curcuma longa l.). | the drug yielding potential of turmeric (curcuma longa l.) is largely due to the presence of phyto-constituent 'curcumin.' curcumin has been found to possess a myriad of therapeutic activities ranging from anti-inflammatory to neuroprotective. lack of requisite high curcumin containing genotypes and variation in the curcumin content of turmeric at different agro climatic regions are the major stumbling blocks in commercial production of turmeric. curcumin content of turmeric is greatly influence ... | 2016 | 27766103 |
| spices: therapeutic potential in cardiovascular health. | dietary factors play a key role in the development as well as prevention of certain human diseases, including cardiovascular diseases. currently there has been an increase in global interest to identify medicinal plants that are pharmacologically effective and have low or no side effects for use in preventive medicine. culinary herbs and spices are an important part of human nutrition in all the cultures of the world. there is a growing amount of literature concerning the potential benefits of t ... | 2016 | 27774899 |
| erythema multiforme-like allergic contact dermatitis to turmeric essential oil. | 2016 | 27775965 | |
| effect of curcumin and paclitaxel on breast carcinogenesis. | global cancer burden increased to 14.1 million new cases in 2012; and breast cancer is the most common cancer in women worldwide, with nearly 1.7 million new cases diagnosed in 2012. curcumin is the major bioactive ingredient extracted from the rhizome of the plant curcuma longa (turmeric). paclitaxel is a microtubule-stabilizing agent originally isolated from the bark of taxus brevifolia. curcumin and paclitaxel were evaluated with two human breast cancer cell lines as the luminal mcf-7 and the ... | 2016 | 27779649 |
| cardioprotective potential of curcumin against norepinephrine-induced cell death: a microscopic study. | cardiomyopathy and associated heart failure continues to be one of the most severe complications that threaten a large population. curcumin, one of the three curcuminoids of the spice turmeric, is very well known for a multitude of health benefits and functions. norepinephrine (ne), a catecholamine and also a stress hormone may cause the cardiomyocytes to develop increased sensitivity to death with its increasing concentrations. in this study, we investigated the cardioprotective effect of curcu ... | 2017 | 27779739 |
| curcumin (diferulolylmethane) reduces transglutaminase 2 overexpression induced by retinoic acid in human nervous cell lines. | curcumin, a naturally occurring compound derived from turmeric (curcuma longa) has long been suggested to have strong therapeutic or preventive potential against human diseases because of its antioxidative, anticancerous, and anti-inflammatory effects. curcumin is known to exert anti-inflammatory effects by interrupting nf-κb signaling at multiple levels. many observations indicate that curcumin shows its valuable potential by inhibiting the activity of i-κb kinase. transglutaminase 2 (tg2) expr ... | 2016 | 27780170 |
| curcumin relaxes precontracted guinea pig gallbladder strips via multiple signaling pathways. | curcumin (diferuloymethane) is the active ingredient of the dietary spice turmeric. curcumin modulates various signalling molecules, including inflammatory agents, transcription factors, protein kinases and cell cycle regulatory proteins. the purpose of this study was to determine if curcumin had an effect on gallbladder motility. | 2015 | 27785305 |
| a new label-free screen for steroid 5α-reductase inhibitors using lc-ms. | steroid 5α-reductase (s5αr) plays an important role in metabolizing testosterone into active androgen dihydrotestosterone (dht) which is involved in many androgen dependent disorders, such as androgenic alopecia, benign prostatic hyperplasia and acne. the method for screening for s5αr inhibition is key in finding new antagonists. in this study, the label-free s5αr inhibitory assay using lc-ms was developed. s5αr type 1 enzyme was obtained from lncap prostate cancer cells. the enzymatic assay was ... | 2016 | 27789379 |
| antimicrobial efficacy of various essential oils at varying concentrations against periopathogen porphyromonas gingivalis. | porphyromonas gingivalis (p.gingivalis) is a notorious perio-pathogen with the ability to evade host defense mechanism and invade into the periodontal tissues. many antimicrobial agents have been tested that curb its growth, although these agents tend to produce side effects such as antibiotic resistance and opportunistic infections. therefore search for naturally occurring anti-microbials with lesser side effects is the need of the hour. | 2016 | 27790572 |
| vitamin e, turmeric and saffron in treatment of alzheimer's disease. | alzheimer's disease (ad) is a growing epidemic and currently there is no cure for the disease. the disease has a detrimental effect on families and will strain the economy and health care systems of countries worldwide. the paper provides a literature review on a few ongoing possible antioxidant therapy treatments for the disease. the paper highlights use of vitamin e, turmeric and saffron for an alternative antioxidant therapy approach. clinical studies report their therapeutic abilities as pro ... | 2016 | 27792130 |
| molecular mechanisms of anti-metastatic activity of curcumin. | cancer is the leading cause of death worldwide. although cancer occurs as a localized disease, its morbidity and mortality rates remain high due to the ability of cancer cells to break-off from the primary tumor and spread to distant organs. currently, chemotherapy is the main treatment for cancer; however, the increase in proportion of drug-resistant cancer cells and unpleasant side-effects of chemotherapy are still the major challenges in cancer therapy. curcumin is a natural polyphenol compou ... | 2016 | 27793885 |
| antidotal effects of curcumin against neurotoxic agents: an updated review. | curcumin (cur), the main phenolic composition in turmeric, shows preventive effects in various diseases. cur is commonly found in the curcuma species and historically applied in herbal medicine. numerous studies have indicated that cur possesses protective effects against toxic agents in the various animal tissues including the brain. this study found that cur may be effective in nervous system problems induced by neurotoxic agents. however, due to the lack of information on human, more investig ... | 2016 | 27794387 |
| dual effect of curcumin-zinc complex in controlling diabetes mellitus in experimentally induced diabetic rats. | ultrasound-assisted extraction of curcumin from curcuma longa was performed in an ultrasonic bath at 30°c using ethanol for 40 min. a successful attempt has been made to prepare curcumin-zinc (zn) complex using a simple chemical procedure. the complex formation and its stoichiometry were characterized using elemental analysis, fourier transform (ft)-ir and uv spectroscopy which revealed the interaction of zn(ii) ion (m) with curcumin (ligand, l) to proceed via (ml) complex type formation. oral a ... | 2016 | 27803448 |
| turmeric powder and its derivatives from curcuma longa rhizomes: insecticidal effects on cabbage looper and the role of synergists. | curcuma longa has well-known insecticidal and repellent effects on insect pests, but its impact on trichoplusia ni is unknown. in this study, the compound ar-turmerone, extracted and purified from c. longa rhizomes, was identified, and its insecticidal effects, along with turmeric powder, curcuminoid pigments and crude essential oil were evaluated against this important agricultural pest. the role of natural (sesamol and piperonal) and synthetic [piperonyl butoxide (pbo)] synergists under labora ... | 2016 | 27804972 |
| the ethanopharmacological aspect of carbon nanodots in turmeric smoke. | smoke manifested ever since our ancient's lit fire; today it has evolved to become an environmental concern. however, medicinal smoke is still part of man's natural remedies, religious and cultural practices too. the asiatic household practice of burning turmeric rhizomes to relieve nose and chest congestion is a well known yet never scientifically authenticated or studied practice. for the first time we investigate the components of these turmeric smudges, validate their antimicrobial and antic ... | 2016 | 27805007 |
| therapeutic potential of curcumin for the treatment of brain tumors. | brain malignancies currently carry a poor prognosis despite the current multimodal standard of care that includes surgical resection and adjuvant chemotherapy and radiation. as new therapies are desperately needed, naturally occurring chemical compounds have been studied for their potential chemotherapeutic benefits and low toxicity profile. curcumin, found in the rhizome of turmeric, has extensive therapeutic promise via its antioxidant, anti-inflammatory, and antiproliferative properties. prec ... | 2016 | 27807473 |
| purification and characterization of novel fibrin(ogen)olytic protease from curcuma aromatica salisb.: role in hemostasis. | the proteases from turmeric species have procoagulant and fibrinogenolytic activity. this provides a scientific basis for traditional use of turmeric to stop bleeding and promote wound healing processes. | 2016 | 27823634 |
| curcumin as a modulator of p-glycoprotein in cancer: challenges and perspectives. | multidrug resistance (mdr) presents a serious challenge to the efficiency of cancer treatment, and may be associated with the overexpression of drug efflux pumps. p-glycoprotein (p-gp) is a drug efflux pump often found overexpressed in cases of acquired mdr. nevertheless, there are no p-gp inhibitors being used in the current clinical practice, due to toxicity problems, drug interactions, or pharmacokinetic issues. therefore, it is important to identify novel inhibitors of p-gp activity or expre ... | 2016 | 27834897 |
| curcumin (turmeric) and cancer. | curcumin is a substance obtained from the root of the turmeric plant, which has the feature of being a yellow or orange pigment. it is also the main component of curry powder commonly used in asian cuisine. curcumin, a substance that has had an important place in traditional indian and chinese medicines for thousands of years, has been the center of interest for scientific studies especially in the field of cancer treatment for several years. laboratory studies have presented some favorable resu ... | 2016 | 27837604 |
| assessing saffron (crocus sativus l.) adulteration with plant-derived adulterants by diffuse reflectance infrared fourier transform spectroscopy coupled with chemometrics. | saffron, the dried red stigmas of the plant crocus sativus l., is well-known as one of the most important and expensive spices worldwide. it is thus highly susceptible to fraudulent practices that employ, among others, plant-derived adulterants. this study presents an application of diffuse reflectance infrared fourier transform spectroscopy (drifts) and chemometric techniques for evaluating adulteration of saffron with six characteristic adulterants of plant origin, i.e. c. sativus stamens, cal ... | 2017 | 27837871 |
| curcumin protects human adipose-derived mesenchymal stem cells against oxidative stress-induced inhibition of osteogenesis. | the detrimental effects of oxidative stress on the skeletal system have been documented, and understanding the mechanisms is important to design a therapeutic strategy. as an antioxidant and anti-inflammatory agent, the active ingredient of turmeric curcumin has been used as medication for numerous complications including bone loss. however, it is unclear if curcumin could influence the osteogenic potential of mesenchymal stem cells (mscs), particularly in oxidative injuries. here we demonstrate ... | 2016 | 27840063 |
| synthesis and biological assessment of novel n-(hydroxy/methoxy)alkyl β-enaminone curcuminoids. | curcumin, a natural compound extracted from the rhizomes of curcuma longa, is known to display pronounced anticancer activity but lacks good pharmacokinetic properties. in that respect, augmenting the water solubility by structural modification of the curcumin scaffold may result in improved bioavailability and pharmacokinetics. a possible scaffold modification, especially important for this study, concerns the imination of the labile β-diketone moiety in curcumin. previous work revealed that no ... | 2016 | 27843113 |
| the effects of herbal composition gambigyeongsinhwan (4) on hepatic steatosis and inflammation in otsuka long-evans tokushima fatty rats and hepg2 cells. | hepatic steatosis has risen rapidly in parallel with a dramatic increase in obesity. the aim of this study was to determine whether the herbal composition gambigyeongsinhwan (4) (ggh(4)), composed of curcuma longa l. (zingiberaceae), alnus japonica (thunb.) steud. (betulaceae), and the fermented traditional korean medicine massa medicata fermentata, regulates hepatic steatosis and inflammation. | 2017 | 27845265 |
| natural product htp screening for antibacterial (e.coli 0157:h7) and anti-inflammatory agents in (lps from e. coli o111:b4) activated macrophages and microglial cells; focus on sepsis. | acute systemic inflammatory response syndrome arising from infection can lead to multiple organ failure and death, with greater susceptibility occurring in immunocompromised individuals. moreover, sub-acute chronic inflammation is a contributor to the pathology of diverse degenerative diseases (parkinson's disease, alzheimer's disease and arthritis). given the known limitations in western medicine to treat a broad range of inflammatory related illness as well as the emergence of antibiotic resis ... | 2016 | 27846826 |
| recent advances in obesity: the role of turmeric tuber and its metabolites in the prophylaxis and therapeutical strategies. | this contribution reviews current literature on the application of turmeric tuber - a commonly used spice - as an anti-obesity agent. following an introduction about the biochemical significance of obesity and characteristics of various groups of natural products applied in the therapy of overweight patients, the authors focus on curcuma secondary metabolites, their pharmacological applications and present a detailed study on the regulatory properties of turmeric towards various biochemical mech ... | 2016 | 27855627 |
| mechanisms of antifungal and anti-aflatoxigenic properties of essential oil derived from turmeric (curcuma longa l.) on aspergillus flavus. | the antifungal activity and potential mechanisms in vitro as well as anti-aflatoxigenic efficiency in vivo of natural essential oil (eo) derived from turmeric (curcuma longa l.) against aspergillus flavus was intensively investigated. based on the previous chemical characterization of turmeric eo by gas chromatography-mass spectrometry, the substantially antifungal activities of turmeric eo on the mycelial growth, spore germination and aflatoxin production were observed in a dose-dependent manne ... | 2017 | 27855875 |
| clinical efficacy of turmeric use in gingivitis: a comprehensive review. | gingivitis affects an estimated 80% of the population, and is characterized as the world's most predominant inflammatory periodontal disease. without intervention, gingivitis can advance to alveolar bone loss. therefore, the primary goal in patients suffering with gingivitis is to control plaque buildup and soft tissue inflammation. current guidelines consider chlorhexidine as the gold standard in the prevention and treatment of gingivitis. however, negative side effects of chlorhexidine, includ ... | 2016 | 27863601 |
| cucurmin; anticancer and antitumor perspectives - a comprehensive review. | cucurmin, a naturally yellow component isolated from turmeric, ability to prevent various life-style related disorders. the current review article mainly emphasizes on different anticancer perspectives of cucurmin i.e. colon, cervical, uterine, ovarian, prostate head and neck, breast, pulmonary, stomach and gastric, pancreatic, bladder oral, oesophageal and bone cancer. it holds a mixture of strong bioactive molecule known as cucurminoids that has ability to reduce cancer/tumor at initial, promo ... | 2016 | 27874279 |
| curcumin generates oxidative stress and induces apoptosis in adult schistosoma mansoni worms. | inducing apoptosis is an interesting therapeutic approach to develop drugs that act against helminthic parasites. researchers have investigated how curcumin (cur), a biologically active compound extracted from rhizomes of curcuma longa, affects schistosoma mansoni and several cancer cell lines. this study evaluates how cur influences the induction of apoptosis and oxidative stress in couples of adult s. mansoni worms. cur decreased the viability of adult worms and killed them. the tegument of th ... | 2016 | 27875592 |
| antiallergic effect of the atomized extract of rhizome of curcuma longa, flowers of cordia lutea and leaves of annona muricata. | allergies are a problem that greatly affects the population, and hence the use of antiallergic medications is fairly widespread. however, these drugs have many adverse effects. the use of medicinal plants could be an option, but they need to be evaluated. | 2016 | 27877047 |
| curcumin use in pulmonary diseases: state of the art and future perspectives. | curcumin (diferuloylmethane) is a yellow pigment present in the spice turmeric (curcuma longa). it has been used for centuries in ayurveda (indian traditional medicine) for the treatment of several diseases. over the last several decades, the therapeutic properties of curcumin have slowly been elucidated. it has been shown that curcumin has pleiotropic effects, regulating transcription factors (e.g., nf-kb), cytokines (e.g., il6, tnf-alpha), adhesion molecules (e.g., icam-1), and enzymes (e.g., ... | 2017 | 27888157 |
| the protective effect of curcumin in olfactory ensheathing cells exposed to hypoxia. | curcumin, a phytochemical component derived from the rhizomes of curcuma longa, has shown a great variety of pharmacological activities, such as anti-inflammatory, anti-tumor, anti-depression and anti-oxidant activity. therefore, in the last years it has been used as a therapeutic agent since it confers protection in different neurodegenerative diseases, cerebral ischemia and excitotoxicity. olfactory ensheathing cells (oecs) are glial cells of the olfactory system. they are able to secrete seve ... | 2017 | 27889433 |
| evaluation of effect of nishamalaki on stz and hfhf diet induced diabetic neuropathy in wistar rats. | diabetic neuropathy is one of the most common complications affecting 50% of diabetic patients. neuropathic pain is the most difficult types of pain to treat. there is no specific treatment for neuropathy. nishamalaki (na), combination of curcuma longa and emblica officinalis used to treat diabetes mellitus (dm). so, efforts were made to test whether na is useful in prevention of diabetic neuropathy. | 2016 | 27891351 |
| comparison of antibacterial efficacy of turmeric extract, morinda citrifolia and 3% sodium hypochlorite on enterococcus faecalis: an in-vitro study. | sodium hypochlorite (naocl), the most commonly used irrigant, has many potential properties like its unique ability to dissolve pulp tissue, excellent antimicrobial activity, but has a cytotoxic effect when injected into periapical tissues. it is also known to produce allergic reactions, foul smell and taste, and potential for corrosion. facultative organisms such as enterococcus faecalis and aerobes like staphylococcus aureus are considered to be the most resistant species and one of the possib ... | 2016 | 27891459 |
| nutrigenomic activity of plant derived compounds in health and disease: results of a dietary intervention study in dog. | the study was conducted to investigate the effects of dietary administrations of four nutraceuticals in dogs. seventy four dogs were enrolled in the trials, 24 healthy dogs were fed with a control diet (ct) and the experimental groups received for 60days the same diet supplemented with nutraceuticals, namely echinacea angustifolia (ea, 0.10mg/kg live weight as echinacoside; 14 dogs), vaccinium myrtillus (vm, 0.20mg/kg live weight as anthocyanidin, 13 dogs), curcuma longa (cl, 6.60mg/kg live weig ... | 2016 | 27892863 |
| the importance of selected spices in cardiovascular diseases. | cardiovascular diseases are the leading cause of death worldwide. literature data indicate that, due to these diseases, approximately 17.5 million people died in 2012. types of cardiovascular disease include ischemic heart disease, cerebrovascular disease, peripheral vascular disease, congenital heart disease, rheumatic heart disease, cardiomyopathy and arrhythmia. proper nutrition is an important factor in reducing the risk of cardiovascular events. an interesting element of our diets is spices ... | 2016 | 27892897 |
| curcumin potentiates the effect of chemotherapy against acute lymphoblastic leukemia cells via downregulation of nf-κb. | acute lymphoblastic leukemia (all) accounts for 30% of all pediatric cancers. currently available treatments exhibit toxicity and certain patients may develop resistance. thus, less toxic and chemoresistance-reversal agents are required. in the present study, the potential effect of curcumin, a component of curcuma longa, as a pharmacological co-adjuvant of several chemotherapeutic agents against all, including prednisone, 6-mercaptopurine, dexamethasone, cyclophosphamide, l-asparaginase, vincri ... | 2016 | 27895780 |
| curcumin suppresses colon cancer cell invasion via ampk-induced inhibition of nf-κb, upa activator and mmp9. | curcumin, an active nontoxic ingredient of turmeric, possesses potent anti-inflammatory, antioxidant and anti-cancer properties; however, the molecular mechanisms of curcumin are not fully understood. the transcription factor nuclear factor-κb (nf-κb) is key in cellular processes, and the expression/activation of urokinase-type plasminogen activator (upa) and matrix metalloproteinase-9 (mmp9) are crucial for cell invasion. the present study investigated the hypothesis that curcumin inhibits colo ... | 2016 | 27895783 |
| curcumin as a multifaceted compound against human papilloma virus infection and cervical cancers: a review of chemistry, cellular, molecular, and preclinical features. | curcumin, the bioactive polyphenolic ingredient of turmeric, has been extensively studied for its effects on human papilloma virus (hpv) infection as well as primary and malignant squamous cervical cancers. hpv infections, especially those related to hpv 16 and 18 types, have been established as the leading cause of cervical cancer; however, there are also additional contributory factors involved in the etiopathogenesis of cervical cancers. curcumin has emerged as having promising chemopreventiv ... | 2016 | 27896883 |
| curcumin: an effective adjunct in patients with statin-associated muscle symptoms? | in spite of the unequivocal efficacy of statins in reducing primary and secondary cardiovascular events, the use of these drugs in a considerable number of patients is limited because of statin intolerance, mainly statin-associated muscle symptoms (sams). sams encompass a broad spectrum of clinical presentations, including mild muscular aching and other types of myalgias, myopathy with the significant elevation of creatine kinase, and the rare but life-threatening rhabdomyolysis. among several p ... | 2017 | 27897416 |
| ethnobotanical survey of cosmetic plants used in marquesas islands (french polynesia). | cosmetic plants and their uses have often been neglected in ethnobotanical surveys which focus mainly on plants with medicinal or food uses. thus, this survey was carried out to specifically investigate cosmetics in a small community and to establish a cosmetopoeia, based on the model of pharmacopoeia for medicinal plants. the geographic spread of the survey covered the marquesas islands, one of the five archipelagos of french polynesia (pacific ocean). this archipelago was also recently investi ... | 2016 | 27899137 |
| pharmacological evaluation for improvement of kanazawa sutra, medicinal thread for anal fistula. | kanazawa sutra (kans) is a medicinal thread that is used for the treatment of anal fistula. it is used as a substitute for kshara sutra (ks) which is used in ayurvedic medicine. kans is composed of ficus carica latex (fcl), capsicum annuum tincture (cat), achyranthes fauriei kshara (which is processed ash from the whole plant) and powdered curcuma longa rhizome (clr). in this study, we evaluated the ingredients of kans by measuring nitric oxide (no) production in murine macrophage-like cell line ... | 2017 | 27900596 |
| transepithelial transport of curcumin in caco-2 cells is significantly enhanced by micellar solubilisation. | curcumin, the active constituent of curcuma longa l. (family zingiberaceae), has gained increasing interest because of its anti-cancer, anti-inflammatory, anti-diabetic, and anti-rheumatic properties associated with good tolerability and safety up to very high doses of 12 g. nanoscaled micellar formulations on the base of tween 80 represent a promising strategy to overcome its low oral bioavailability. we therefore aimed to investigate the uptake and transepithelial transport of native curcumin ... | 2017 | 27900602 |
| physicochemical/photophysical characterization and angiogenic properties of curcuma longa essential oil. | this study analyzed the physicochemical and photophysical properties of essential oil of curcuma longa and its angiogenic potential. the results showed that curcumin is the main fluorescent component present in the oil, although the amount is relatively small. the experimental chorioallantoic membrane model was used to evaluate angiogenic activity, showing a significant increase in the vascular network of curcuma longa and positive control groups when compared to the neutral and inhibitor contro ... | 2016 | 27901193 |
| a novel curcumin derivative which inhibits p-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells. | cancer multidrug resistance (mdr) is a major limitation to the success of cancer treatment and is highly associated with the overexpression of drug efflux pumps such as p-glycoprotein (p-gp). in order to achieve more effective chemotherapeutic treatments, it is important to develop p-gp inhibitors to block/decrease its activity. curcumin (1) is a secondary metabolite isolated from the turmeric of curcuma longa l.. diverse biological activities have been identified for this compound, particularly ... | 2017 | 27908756 |
| termitarium-inhabiting bacillus spp. enhanced plant growth and bioactive component in turmeric (curcuma longa l.). | curcumin (diferuloyl methane) is the main bioactive component of turmeric (curcuma longa l.) having remarkable multipotent medicinal and therapeutic applications. two bacilli isolated from termitarium soil and identified as bacillus endophyticus tsh42 and bacillus cereus tsh77 were used for bacterization of rhizome for raising c. longa ver. suguna for growth and enhancement. both the strains showed remarkable pgp activities and also chemotactic in nature with high chemotactic index. turmeric pla ... | 2017 | 27913879 |
| cardioprotective effects of curcumin-loaded magnetic hydrogel nanocomposite (nanocurcumin) against doxorubicin-induced cardiac toxicity in rat cardiomyocyte cell lines. | curcumin, is a yellow substance extracted from curcuma longa rhizomes, it is a crystalline compound that has been traditionally applied in culinary practices and medicines in india. the aim of our study is to demonstrate the efficacy of curcumin-loaded magnetic hydrogel nanocomposite in the treatment of heart hypertrophy. 10 rats weighing 150-200 g each were induced with heart failure using 2.5 mg/kg doxorubicin for 2 weeks. the test groups were treated with curcumin-loaded magnetic hydrogel nan ... | 2017 | 27924631 |
| turmeric: a spice for life? | 2016 | 27924745 | |
| add some spice to ease creaking joints. | cinnamon, black pepper, turmeric, ginger - these spices have been lurking in the back of my kitchen cupboard for years, only making an appearance at christmas and for the odd curry. | 2016 | 27925572 |
| antioxidant effects of curcuminoids in patients with type 2 diabetes mellitus: a randomized controlled trial. | oxidative stress has a key role in the pathogenesis of type ii diabetes mellitus (t2dm) and its vascular complications. antioxidant therapy has been suggested as a potential approach to blunt t2dm development and progression. the aim of this study was to assess the effects of supplementation with curcuminoids, which are natural polyphenolics from turmeric, on oxidative indices in diabetic individuals. | 2017 | 27928704 |
| phytosomal curcumin: a review of pharmacokinetic, experimental and clinical studies. | curcumin, a hydrophobic polyphenol, is the principal constituent extracted from dried rhizomes of curcuma longa l. (turmeric). curcumin is known as a strong anti-oxidant and anti-inflammatory agent that has different pharmacological effects. in addition, several studies have demonstrated that curcumin is safe even at dosages as high as 8g per day; however, instability at physiological ph, low solubility in water and rapid metabolism results in a low oral bioavailability of curcumin. the phytosom ... | 2017 | 27930973 |
| natural product htp screening for attenuation of cytokine-induced neutrophil chemo attractants (cincs) and no2- in lps/ifnγ activated glioma cells. | chronic and acute central nervous system (cns) inflammation are contributors toward neurological injury associated with head trauma, stroke, infection, parkinsons or alzheimers disease. cns inflammatory illnesses can also contribute toward risk of developing glioblastoma multiforme (gbm). with growing public interest in complementary and alternative medicines (cams), we conduct a high throughput (htp) screening of >1400 natural herbs, plants and over the counter (otc) products for anti-inflammat ... | 2017 | 27956075 |
| antibacterial action of curcumin against staphylococcus aureus: a brief review. | curcumin, the major constituent of curcuma longa l. (zingiberaceae family) or turmeric, commonly used for cooking in asian cuisine, is known to possess a broad range of pharmacological properties at relatively nontoxic doses. curcumin is found to be effective against staphylococcus aureus (s. aureus). as demonstrated by in vitro experiment, curcumin exerts even more potent effects when used in combination with various other antibacterial agents. hence, curcumin which is a natural product derived ... | 2016 | 27956904 |
| evaluating the efficacy of denture cleansing materials in removal of tea and turmeric stains: an in vitro study. | extrinsic staining of acrylic resin dentures could be a major esthetic problem for denture wearers. tea, coffee, cola, turmeric, and tobacco often cause extrinsic staining of dentures. | 2016 | 27966512 |
| a highly selective nanocomposite based on mip for curcumin trace levels quantification in food samples and human plasma following optimization by central composite design. | a selective and rapid method was developed for quantification of curcumin in human plasma and food samples using molecularly imprinted magnetic multiwalled carbon nanotubes (mmwcnts) which was characterized with edx and fesem. the role of sorbent mass, volume of eluent and sonication time on response in solid phase microextraction procedure were optimized by central composite design (ccd) combined with response surface methodology (rsm) using statistica. preliminary experiments reveal that among ... | 2017 | 27978467 |
| cloud point extraction and diffuse reflectance-fourier transform infrared spectroscopic determination of chromium(vi): a probe to adulteration in food stuffs. | a new cloud point extraction (cpe) method for the determination of hexavalent chromium i.e. cr(vi) in food samples is established with subsequent diffuse reflectance-fourier transform infrared (drs-ftir) analysis. the method demonstrates enrichment of cr(vi) after its complexation with 1,5-diphenylcarbazide. the reddish-violet complex formed showed λmax at 540nm. micellar phase separation at cloud point temperature of non-ionic surfactant, triton x-100 occurred and complex was entrapped in surfa ... | 2017 | 27979229 |
| curcumin attenuates blood-brain barrier disruption after subarachnoid hemorrhage in mice. | early brain injury, one of the most important mechanisms underlying subarachnoid hemorrhage (sah), comprises edema formation and blood-brain barrier (bbb) disruption. curcumin, an active extract from the rhizomes of curcuma longa, alleviates neuroinflammation by as yet unknown neuroprotective mechanisms. in this study, we examined whether curcumin treatment ameliorates sah-induced brain edema and bbb permeability changes, as well as the mechanisms underlying this phenomenon. | 2017 | 27979493 |
| characterisation of chemical components for identifying historical chinese textile dyes by ultra high performance liquid chromatography - photodiode array - electrospray ionisation mass spectrometer. | this research makes the first attempt to apply ultra high performance liquid chromatography (uhplc) coupled to both photodiode array detection (pda) and electrospray ionisation mass spectrometer (esi-ms) to the chemical characterisation of common textile dyes in ancient china. three different extraction methods, respectively involving dimethyl sulfoxide (dmso)-oxalic acid, dmso and hydrochloric acid, are unprecedentedly applied together to achieve an in-depth understanding of the chemical compos ... | 2017 | 27986289 |
| microwave-assisted enhancement of milkweed (calotropis procera l.) leaves as an eco-friendly source of natural colorants for textile. | application of natural colorants to textile fabrics has gained worldwide public acceptance due to the hazardous nature of synthetic dyes. present study investigated the microwave's mediated extraction of natural colorants from leaves of milkweed (calotropis procera l.) as well as their application to cotton fabrics assisted with biochemical mordants. dye extraction from c. procera leaves was carried out in various mediums (alkali and aqueous), and the extracted dye as well as cotton fabrics was ... | 2017 | 27988899 |
| curcumin improves glucose tolerance via stimulation of glucagon-like peptide-1 secretion. | glucagon-like peptide-1 (glp-1) is a type of incretin secreted from enteroendocrine l-cells. our previous studies demonstrated that curcumin (a yellow pigment of turmeric) significantly increases the secretion of glp-1 in enteroendocrine l cell line (glutag cells). however, it is not clear whether its action in vivo directly enhances glp-1 secretion, which then leads to a reduction in blood glucose levels via the stimulation of insulin secretion. in addition, the molecular target of curcumin-ind ... | 2017 | 27990751 |
| curcumin, a compound from natural sources, a true scientific challenge - a review. | curcumin, a plant-derived polyphenolic compound, naturally present in turmeric (curcuma longa), has been the subject of intensive investigations on account of its various activities. the implementation of safe, beneficial and highly functional compounds from natural sources in human nutrition/prevention/therapy requires some modifications in order to achieve their multi-functionality, improve their bioavailability and delivery strategies, with the main aim to enhance their effectiveness. the low ... | 2017 | 27995378 |
| investigating the neuroprotective effects of turmeric extract: structural interactions of β-amyloid peptide with single curcuminoids. | a broad biophysical analysis was performed to investigate the molecular basis of the neuroprotective action of curcuma longa extracts in alzheimer's disease. by combining circular dichroism and electron paramagnetic resonance experiments with molecular modeling calculations, the minor components of curcuma longa extracts, such as demethoxycurcumin (2, dmc), bisdemethoxycurcumin (3, bdmc) and cyclocurcumin (4, cyc), were analyzed in a membrane environment mimicking the phospholipid bilayer. our s ... | 2016 | 28004737 |
| curcumin inhibits growth potential by g1 cell cycle arrest and induces apoptosis in p53-mutated colo 320dm human colon adenocarcinoma cells. | curcumin, a natural polyphenolic compound and it is isolated from the rhizome of curcuma longa, have been reported to possess anticancer effect against stage i and ii colon cancer. however, the effect of curcumin on colon cancer at dukes' type c metastatic stage iii remains still unclear. in the present study, we have investigated the anticancer effects of curcumin on p53 mutated colo 320dm human colon adenocarcinoma cells derived from dukes' type c metastatic stage. the cellular viability and p ... | 2017 | 28011386 |
| recent progress on curcumin-based therapeutics: a patent review (2012-2016). part i: curcumin. | curcumin is the main bioactive component contained in curcuma longa, largely employed in traditional medicine. recently, beneficial properties, useful for prevention and treatment of several disorders, have been discovered for this compound. peculiar structural feature is an α,β-unsaturated carbonyl system essential for establishing contacts with critical cysteine residues of several targets. this distinctive mechanism of action imparts to the molecule the ability to affect a large number of tar ... | 2017 | 28024125 |
| a comprehensive approach to ascertain the binding mode of curcumin with dna. | curcumin is a natural phytochemical from the rhizoma of curcuma longa, the popular indian spice that exhibits a wide range of pharmacological properties like antioxidant, anticancer, anti-inflammatory, antitumor, and antiviral activities. in the published literatures we can see different studies and arguments on the interaction of curcumin with dna. the intercalative binding, groove binding and no binding of curcumin with dna were reported. in this context, we conducted a detailed study to under ... | 2017 | 28033562 |
| curcumin: a potentially powerful tool to reverse cisplatin-induced toxicity. | curcumin is a naturally occurring polyphenol isolated from curcuma longa that has gained considerable interest over the last decades due to its beneficial effects for human health. moreover, the usage of cisplatin, a platinum-based chemotherapeutic, is associated with several adverse effects affecting the quality of life of the patients. also, cisplatin therapy is jeopardized by a great challenge of resistance which reduces the efficacy of this drug. in order to conquer these dark sides of cispl ... | 2017 | 28042086 |
| assessment of cytotoxic activity of rosemary (rosmarinus officinalis l.), turmeric (curcuma longa l.), and ginger (zingiber officinale r.) essential oils in cervical cancer cells (hela). | the objective of this study was to evaluate the cytotoxic activity of rosemary (reo, rosmarinus officinalis l.), turmeric (ceo, curcuma longa l.), and ginger (geo, zingiber officinale r.) essential oils in hela cells. cytotoxicity tests were performed in vitro, using tetrazolium (mtt) and neutral red assays for evaluation of antiproliferative activity by different mechanisms, trypan blue assay to assess cell viability and evaluation of cell morphology for giemsa to observe the cell damage, and a ... | 2016 | 28042599 |
| a method for the preparation of curcumin by ultrasonic-assisted ammonium sulfate/ethanol aqueous two phase extraction. | this study investigated a new and easy-to-industrialized extracting method for curcumin from curcuma longa rhizomes using ultrasonic extraction technology combined with ammonium sulfate/ethanol aqueous two-phase system (atps), and the preparation of curcumin using the semi-preparative hplc. the single-factor experiments and response surface methodology (rsm) were utilized to determine the optimal material-solvent ratio, ultrasonic intensity (ui) and ultrasonic time. the optimum extraction condit ... | 2017 | 28043027 |
| effects of extracts from tiaozhi granule and its components on expression of scavenger receptor class b type i. | sera from the rats with different drug treatments (atorvastatin, tiaozhi granule, or its extracts) were collected. lo-2 cells or hepg2 cells were pretreated with different sera as the following groups randomly: (1) blank control group, (2) positive control group (atorvastatin group), (3) tiaozhi granule water extract groups, (4) tiaozhi granule alcohol extract groups, and (5) alcohol extracts for each component: pollen typhae angustifoliae, curcuma longa l., and rhizoma alismatis. lo-2 cells wer ... | 2016 | 28050195 |
| in vitro effectiveness of curcuma longa and zingiber officinale extracts on echinococcus protoscoleces. | hydatid disease is an important economic and human public health problem with a wide geographical distribution. surgical excision remains the primary treatment and the only hope for complete cure of hydatosis. the most important complications arising from surgical excision, however, is recurrence, which is due to dissemination of protoscolices during the surgery. pre-surgical inactivation of the contents of the hydatid cyst by injection of scolicidal agent into the cyst has been used as adjunct ... | 2017 | 28053576 |
| curcumin reverses neurochemical, histological and immuno-histochemical alterations in the model of global brain ischemia. | curcumin, a curcuminoid from curcuma longa, presents antioxidant and anti-inflammatory actions and, among pathological changes of cerebral ischemic injury, inflammation is an important one. the objectives were to study the neuroprotective action of curcumin, in a model of global ischemia. male wistar rats (sham-operated, ischemic untreated and ischemic treated with curcumin, 25 or 50 mg/kg, p.o.) were anesthesized and their carotid arteries occluded, for 30 min. the so group had the same procedu ... | 2017 | 28053883 |
| sensory evaluation of gluten-free quinoa whole grain snacks. | sensory evaluation of quinoa gluten-free whole grain low fat and salt snacks was conducted. the snacks were quinoa, quinoa-cayenne pepper, quinoa-ginger and quinoa-turmeric. cayenne pepper, ginger and turmeric are common spices that contain health promoting nutrients. cayenne pepper has been associated with enhancing heat production. ginger has been reported to improve blood flow and prevent joint pains. turmeric has been observed to have wound healing potential. all the snacks contained 6% corn ... | 2016 | 28054034 |
| curcumin, an atoxic antioxidant and natural nfκb, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases. | the world suffers a tsunami of chronic diseases, and a typhoon of acute illnesses, many of which are associated with the inappropriate or exaggerated activation of genes involved in inflammation. finding therapeutic agents which can modulate the inflammatory reaction is the highest priority in medical research today. drugs developed by the pharmaceutical industry have thus far been associated with toxicity and side effects, which is why natural substances are of increasing interest. | 2006 | 28059012 |
| therapeutic effects of curcumin in inflammatory and immune-mediated diseases: a nature-made jack-of-all-trades? | curcumin is a dietary polyphenol from turmeric with numerous pharmacological activities. novel animal and human studies indicate that curcumin can affect different immune cells, such as various t lymphocyte subsets, macrophages, dendritic cells, b lymphocytes and natural killer cells, which results in decreasing severity of various diseases with immunological etiology. the present review provides a comprehensive overview of the effects of curcumin on different immune cells and immune system-rela ... | 2017 | 28059453 |
| tiny molecule, big power: multi-target approach for curcumin in diabetic cardiomyopathy. | diabetic cardiomyopathy (dcm) is described as impaired cardiac diastolic and systolic functions. diabetes mellitus (dm), a related cardiovascular disease, has become one of the major causes of death in dm patients. mortality in these diseases is 2 to 3 times higher than in non-dm patients with cardiovascular disease. the progression of dcm and the cellular and molecular perturbations associated with the pathogenesis are complex and multifactorial. although considerable progress has been achieved ... | 2017 | 28063511 |
| cyclocurcumin, an antivasoconstrictive constituent of curcuma longa (turmeric). | despite the increasing attention on the therapeutic potential of curcuma longa (turmeric), the biological activities of curcuminoids other than curcumin are not well understood. here, we investigated antivasoconstrictive activities of c. longa extract and its ingredients using freshly isolated rat aortic rings. c. longa extract significantly suppressed agonist-stimulated vasoconstriction, and cyclocurcumin was found to be the most potent (ic50 against phenylephrine-induced vasoconstriction: 14.9 ... | 2017 | 28068085 |
| rapid classification of turmeric based on dna fingerprint by near-infrared spectroscopy combined with moving window partial least squares-discrimination analysis. | in this research, near-infrared (nir) spectroscopy in combination with moving window partial least squares-discrimination analysis (mwpls-da) was utilized to discriminate the variety of turmeric based on dna markers, which correlated to the quantity of curcuminoid. curcuminoid was used as a marker compound in variety identification due to the most pharmacological properties of turmeric possessed from it. mwpls-da optimized informative nir spectral regions for the fitting and prediction to {-1/1} ... | 2017 | 28070064 |
| curcumin induces apoptosis in human leukemic cell lines through an ifit2-dependent pathway. | curcumin, the primary bioactive component isolated from turmeric, has been shown to possess variety of biologic functions including anti-cancer activity. however, molecular mechanisms in different cancer cells are various. in the present study, we demonstrated that curcumin induced g2/m cell cycle arrest and apoptosis by increasing the expression levels of cleaved caspase-3, cleaved parp and decreasing the expression of bcl(-)2 in u937 human leukemic cells but not in k562 cells. we found some in ... | 2017 | 28071969 |
| the essential medicinal chemistry of curcumin. | curcumin is a constituent (up to ∼5%) of the traditional medicine known as turmeric. interest in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led to their extensive investigation. curcumin has recently been classified as both a pains (pan-assay interference compounds) and an imps (invalid metabolic panaceas) candidate. the likely false activity of curcumin in vitro and in vivo has resulted in >120 clinical trials of curcuminoids against several diseases. ... | 2017 | 28074653 |
| promising anti-tumor properties of bisdemethoxycurcumin: a naturally occurring curcumin analogue. | curcuminoids are turmeric-extracted phytochemicals with documented chemopreventive and anti-tumor activities against several types of malignancies. curcuminoids can modulate several molecular pathways and cellular targets involved in different stages of tumor initiation, growth and metastasis. bisdemethoxycurcumin (bdmc) is a minor constituent (approximately 3%) of curcuminoids that has been shown to be more stable than the other two main curcuminoids i.e. curcumin and demthoxycurcumin. recent s ... | 2017 | 28075008 |
| curcuma longa as additive in the diet for astyanax aff. bimaculatus. | the aim of the present study was to evaluate the effect of turmeric (curcuma longa) as additive in the diet for astyanax aff. bimaculatus. fish (0.83 ± 0.04 g) were fed, for 60 days, with six diets containing 0.0, 20.0, 40.0, 60.0, 80.0, and 100.0 g turmeric kg(-1) feed. there was an increasing linear effect of turmeric on the thickness of the muscular layer, and height and width of the folds of the intestine. in the liver, a quadratic effect was observed of turmeric on the percentage of hepatoc ... | 2017 | 28083736 |
| ethnobotanics used in folk medicine of tamil culture in sri lanka: a scientific review. | tamil culture has recognized the potential use of plant herbs for prevention and treatment of different diseases. these folk remedies have been practiced by sri lankan tamils even after modernization. this review focuses on frequently used medicinal plants among sri lankan tamil communities, such as cuminum cyminum, azadirechta indica, coriandrum sativum, sesamum indicum, zingiber officinale, trigonella foenum-graecum, moringa oleifera, plectranthus amboinicus, allium sativum and curcuma longa, ... | 2017 | 28088256 |
| complications of hot turmeric use in acute trauma. | the use of hot tumeric paste for treatment of musculoskeletal injuries is a home remedy commonly used in oman. this practice occasionally leads to skin burns complicating an already injured extremity. this case report discusses the uses of tumeric as a medicine as well as the management of the complication arising from its improper use as illustrated in this case. | 2010 | 28090267 |
| anti-amnestic effect of curcumin in combination with donepezil, an anticholinesterase drug: involvement of cholinergic system. | recently, combination therapy involving cholinesterase (che) inhibitor with other neuroprotective agents has shown better desirable effect in the management/prevention of dementia but limited information is available on their effect with dietary polyphenols. hence, this study sought to assess the combined pretreatment effect of curcumin, the major polyphenolic compound of turmeric (curcuma longa) rhizomes, with donepezil, a cholinesterase inhibitor, on cognitive function in scopolamine-induced m ... | 2017 | 28102474 |
| acute calcineurin inhibitor nephrotoxicity secondary to turmeric intake: a case report. | tacrolimus, also known as fk-506, is a potent immunosuppressant agent with a host of drug-drug and food-drug interactions. we present the first case of a probable food-drug interaction between the herb turmeric and tacrolimus leading to acute calcineurin inhibitor nephrotoxicity. a 56-year-old man with a history of orthotopic liver transplantation presented to the emergency department from the clinic with worsening edema in the setting of an elevated creatinine level of 4.2 mg/dl. before the cur ... | 2017 | 28104136 |
| curcumin suppresses the proliferation of gastric cancer cells by downregulating h19. | curcumin, a major phytochemical in turmeric, inhibits the proliferation of many types of solid cancer cells by enhancing p53 expression. however, the long non-coding rna h19 directly inhibits p53 activation and thus promotes gastric cancer progression. the aim of this study was to assess the role of h19 in curcumin-induced proliferative inhibition of gastric cancer. the gastric cancer cell line sgc-7901 was treated with curcumin at different concentrations and time points. the effect of curcumin ... | 2016 | 28105222 |
| demethoxycurcumin preserves renovascular function by downregulating cox-2 expression in hypertension. | hypertension-associated endothelial dysfunction is largely due to the exaggerated vasoconstrictor generation by cyclooxygenase-2 (cox-2). cox-2 is induced under inflammatory condition. demethoxycurcumin (dmc) is a major component of curcuma longa l, which possesses anti-inflammatory action. this study aimed to examine whether dmc protects endothelial function in hypertension by modulating cox-2. changes in isometric tension showed that in vivo and ex vivo treatment with dmc rescued the attenuate ... | 2016 | 28105253 |
| κ-carrageenan: an effective drug carrier to deliver curcumin in cancer cells and to induce apoptosis. | the current study is to develop a natural drug carrier with seaweed derived polymers namely κ-carrageenan (κ-car) for drug delivery applications. κ-car is a natural polysaccharide which derived from edible red seaweeds, they are easily available, non-toxic, cost effective, biodegradable and biocompatible nature. curcumin (cur) is a yellow-orange polyphenol existing in turmeric, which is predominantly used as spice and food coloring agent. the ultimate use of polymeric composites, especially thos ... | 2017 | 28115093 |
| curcumin and turmeric modulate the tumor-promoting effects of iron in vitro. | free or loosely chelated iron has tumor-promoting properties in vitro. curcumin, a polyphenol derived from the food spice turmeric (curcuma longa), is a potent antioxidant that binds iron. the primary aim of this study was to investigate whether curcuminoids prevent tumor-promoting effects of iron in t51b cells, a non-neoplastic rat liver epithelial cell line. purified curcuminoids (curcumin) or a standardized turmeric extract similarly reduced oxidative stress and cytotoxicity associated with i ... | 2017 | 28129008 |
| in vitro antioxidant effect of curcumin on human sperm quality in leucocytospermia. | decreased sperm quality was caused by oxidative stress in semen from patients with leucocytospermia. curcumin is a traditional chinese herbal monomer extracted from zingiberaceae turmeric and zedoary turmeric and has antioxidative and anti-inflammatory effects. this study aimed to investigate the effects and specific molecular mechanisms of curcumin on sperm quality in patients diagnosed with leucocytospermia. forty cases of semen samples were collected from patients with leucocytospermia and 35 ... | 2017 | 28133770 |