Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| curcumin inhibits tpa induced expression of c-fos, c-jun and c-myc proto-oncogenes messenger rnas in mouse skin. | curcumin is a major chemical constituent of turmeric normally eaten by humans. 12-o-tetradecanoyl phorbol-13-acetate (tpa) is a strong promoter of chemically induced skin cancer. the exact mechanism by which tpa promotes skin cancer is not clear. however, it is known that tpa elevates the expression of oncogenes involved in cell proliferation. recently, it has been shown that turmeric or curcumin significantly inhibits tpa-induced tumor promotion on mouse skin. however, the mechanism by which cu ... | 1994 | 7954373 |
| inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice. | curcumin (diferuloylmethane), a yellow pigment that is obtained from the rhizomes of curcuma longa linn., is a major component of turmeric and is commonly used as a spice and food-coloring agent. the inhibitory effects of feeding commercial grade curcumin (77% curcumin, 17% demethoxycurcumin, and 3% bisdemethoxycurcumin) in ain 76a diet on carcinogen-induced tumorigenesis in the forestomach, duodenum, and colon of mice were evaluated. administration p.o. of commercial grade curcumin in the diet ... | 1994 | 7954412 |
| curcuma longa linn. in the treatment of gastric ulcer comparison to liquid antacid: a controlled clinical trial. | 1993 | 7964234 | |
| role of capsaicin, curcumin and dietary n-3 fatty acids in lowering the generation of reactive oxygen species in rat peritoneal macrophages. | reactive oxygen species (ros) generated by activated macrophages play an important role in the initiation of inflammation. ten different spice principles, some of which with known anti-inflammatory properties, were tested for their effect on generation of superoxide anions, hydrogen peroxide and nitrite radical generation by activated rat peritoneal macrophages. preincubation of macrophages with 10 microm capsaicin (from red pepper) or 10 microm curcumin (from turmeric) completely inhibited the ... | 1994 | 7981240 |
| photocytotoxicity of curcumin. | curcumin, bis(4-hydroxy-3-methoxyphenyl)-1,6-diene-3,5-dione, is a yellow-orange dye derived from the rhizome of the plant curcuma longa. curcumin has demonstrated phototoxicity to several species of bacteria under aerobic conditions (dahl, t. a., et al., 1989, arch. microbiol. 151 183), denoting photodynamic inactivation. we have now found that curcumin is also phototoxic to mammalian cells, using a rat basophilic leukemia cell model, and that this phototoxicity again requires the presence of o ... | 1994 | 8016207 |
| spectral and photochemical properties of curcumin. | curcumin, bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, is a natural yellow-orange dye derived from the rhizome of curcuma longa, an east indian plant. in order to understand the photobiology of curcumin better we have studied the spectral and photochemical properties of both curcumin and 4-(4-hydroxy-3-methoxy-phenyl)-3-buten-2-one (hc, half curcumin) in different solvents. in toluene, the absorption spectrum of curcumin contains some structure, which disappears in more polar solvent ... | 1994 | 8016208 |
| knowledge, attitude and beliefs about malaria in a tribal area of bastar district (madhya pradesh). | a sample survey of k.a.p. about malaria was carried out among sample of 359 inhabitants selected by random sampling in a tribal area of baster district, which is a hyper-endemic area of the disease, predominantly by p.falciparum infection and understanding about the problem of malaria was poor, only about 50% (ranging from 30% to 60%) of the respondents were aware about cause and signs and symptoms of malaria, breeding & resting habit of mosquito, usefulness of insecticidal spray and ill effect ... | 1993 | 8077001 |
| inhibition of the hiv-1 and hiv-2 proteases by curcumin and curcumin boron complexes. | curcumin, a relatively non-toxic natural product isolated from curcuma longa, is a modest inhibitor of the hiv-1 (ic50 = 100 microm) and hiv-2 (ic50 = 250 microm) proteases. simple modifications of the curcumin structure raise the ic50 value but complexes of the central dihydroxy groups of curcumin with boron lower the ic50 to a value as low as 6 microm. the boron complexes are also time-dependent inactivators of the hiv proteases. the increased affinity of the boron complexes may reflect bindin ... | 1993 | 8087563 |
| retention of ascorbic acid in pickles--effect of different spices and salt (an in vitro study). | effect of spices, different concentration of sodium chloride and other salts on retention of ascorbic acid during storage period (21 days in case of spices and eight days for salts) was studied. the retention of ascorbic acid with the addition of 24% nacl was 55%, followed by 37% with red chillies, fenugreek, turmeric; 32% with the addition of pepper, sugar and 26% with mustard and asafoetida. when all the spices and salt were added together, the retention was much higher (73%) than those with i ... | 1993 | 8121472 |
| highlight on the studies of anticancer drugs derived from plants in china. | recent progress on the study of anticancer drugs originating from plants in china is reviewed in this paper. guided by the experience of traditional chinese medicine, several new drugs have been found. indirubin from indigofera tinctoria is useful for the treatment of chronic myelocytic leukemia. irisquinone from iris latea pallasii and 10-hydroxy camptothecin from camptotheca accuminata have exhibited definite activity on rodent tumors. recent studies indicate that ginsenoside rh2 is an inducer ... | 1994 | 8142920 |
| identification of an active principle in essential oils and hexane-soluble fractions of curcuma xanthorrhiza roxb. showing triglyceride-lowering action in rats. | curcuma xanthorrhiza roxb. (c. xanthorrhiza), known as temu lawak or javanese turmeric, has been traditionally used in indonesia for food and medicinal purposes. as little attention has been focused on the role of c. xanthorrhiza in lipid metabolism, the hypotriglyceridaemic activity and the active principles of the essential oil and hexane-soluble fractions prepared from c. xanthorrhiza were investigated in rats. the major component (approx. 65%) of the essential oil was identified as alpha-cur ... | 1994 | 8157222 |
| effect of dietary turmeric (curcuma longa) on iron-induced lipid peroxidation in the rat liver. | male wistar rats were fed a control diet or the control diet supplemented with 1% (by weight) turmeric for 10 wk. in rats injected with 30 mg fe2+/kg body weight, lipid peroxidation was 29 and 35% lower in liver homogenates and microsomes, respectively, of turmeric-fed rats than in those of rats fed the control diet. the activities of superoxide dismutase, catalase and glutathione peroxidase were higher (by 19, 19 and 20%, respectively) in liver homogenates of rats fed the turmeric-containing di ... | 1994 | 8157223 |
| in vitro studies on chemoprotective effect of purnark against benzo(a)pyrene-induced chromosomal damage in human lymphocytes. | human lymphocytes were used as an assay system to test chemopreventive activity of natural products. purnark, a mixture of extracts of turmeric, betel leaf and catechu, was tested for its chemoprotective activity against bp induced dna damage. sister chromatid exchange and micronuclei were used as markers to assess the protective activity of purnark. purnark gave 50-60% protection against bp induced sces and micronuclei. purnark at 100 micrograms dose did not show any genotoxicity. | 1994 | 8186767 |
| nematocidal activity of turmeric: synergistic action of curcuminoids. | a new curcuminoid, cyclocurcumin (iv), was isolated from the nematocidally active fraction of turmeric, the rhizome of curcuma longa, together with three known curcuminoids, curcumin (i), demethoxycurcumin (ii) and bisdemethoxycurcumin (iii). the structure of iv was elucidated on the basis of spectral data and confirmed by the partial synthesis from curcumin (i). although the above curcuminoids were ineffective when they were applied independently, the nematocidal activity increased remarkably w ... | 1993 | 8221978 |
| inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon. | the present study was designed to investigate the modulatory role of dietary curcumin on (i) azoxymethane (aom)-induced ornithine decarboxylase (odc), tyrosine protein kinase (tpk) and arachidonic acid metabolism in liver and colonic mucosa of male f344 rats, (ii) in vitro arachidonic acid metabolism in the liver and colonic mucosa and (iii) aom-induced aberrant crypt foci (acf) formation in the colon of f344 rats. at 5 weeks of age groups of animals were fed one of the experimental diets contai ... | 1993 | 8242846 |
| spice allergy evaluated by results of patch tests. | allergic contact dermatitis caused by spices is well documented; however, commercial patch tests are unavailable. between october, 1991, and august, 1992, a series of fifty-five patients with suspected contact dermatitis were tested at ochsner clinic for sensitivity to a group of spices at concentrations of 10 percent and 25 percent in petrolatum. concordant patch test results (positive at concentrations of 10 percent and 25 percent) were most common with ginger (seven), nutmeg(five), and oregan ... | 1993 | 8299390 |
| effect of turmeric on xenobiotic metabolising enzymes. | diet contains several substances capable of inhibiting chemical carcinogenesis. it is known that such inhibitors may either act directly by scavenging the reactive substances or indirectly by promoting mechanisms which enhance detoxification. turmeric which contains curcumin both in vitro and in vivo is an active antimutagen. studies were therefore conducted to evaluate the effects of turmeric on xenobiotic metabolising enzymes in hepatic tissue of rats fed turmeric ranging from 0.5-10% in the d ... | 1993 | 8332589 |
| arabinogalactan core structure and immunological activities of ukonan c, an acidic polysaccharide from the rhizome of curcuma longa. | controlled smith degradation of ukonan c, a phagocytosis-activating polysaccharide isolated from the rhizome of curcuma longa l., was performed. the reticuloendothelial system-potentiating, anti-complementary and alkaline phosphatase-inducing activities of ukonan c and its degradation products were investigated. methylation analyses of the primary and secondary smith degradation products and of a de-arabinosylated product indicated that structural features of the arabinogalactan core of ukonan c ... | 1993 | 8364466 |
| scavenging of superoxide anions by spice principles. | effect of spice principles on scavenging of superoxide anion has been investigated. the superoxide anions, as measured by nitrobluetetrazolium (nbt) reduction in xanthine-xanthine oxidase system, were inhibited by superoxide dismutase, spice principles eugenol (cloves) and cuminaldehyde (cumin), antioxidants, butylated hydroxy toluene and butylated hydroxyanisole in a dose-dependent manner. the k(i) values for the inhibition of nbt reduction by eugenol and cuminaldehyde were 64 microm and 120 mi ... | 1993 | 8394839 |
| effect of turmeric and curcumin on bp-dna adducts. | many human cancers that are widely prevalent today can be prevented through modifications in life-styles, of which diet appears to be an important agent. several dietary constituents modulate the process of carcinogenesis and prevent genotoxicity. many plant constituents including turmeric appear to be potent antimutagens and antioxidants. therefore the modulatory effects of turmeric and curcumin on the levels of benzo[a]pyrene induced dna adducts in the livers of rats were studied by the newly ... | 1993 | 8453726 |
| mechanism of antiinflammatory actions of curcumine and boswellic acids. | curcumine from curcuma longa and the gum resin of boswellia serrata, which were demonstrated to act as anti-inflammatories in in vivo animal models, were studied in a set of in vitro experiments in order to elucidate the mechanism of their beneficial effects. curcumine inhibited the 5-lipoxygenase activity in rat peritoneal neutrophils as well as the 12-lipoxygenase and the cyclooxygenase activities in human platelets. in a cell free peroxidation system curcumine exerted strong antioxidative act ... | 1993 | 8510458 |
| antioxidative activity of tetrahydrocurcuminoids. | in order to develop a new type of antioxidative compound which has both the phenolic and beta-diketone moiety in the same molecule, we converted three known curcuminoids, curcumin (diferuloylmethane, u1), (4-hydroxy-3-methoxycinnamoyl)methane (u2), and bis-(4-hydroxycinnamoyl)methane (u3), which are the natural antioxidants of curcuma longa l. (tumeric), to tetrahydrocurcuminoids (thu1, thu2, and thu3, respectively) by hydrogenation, and evaluated their antioxidative activity by using linoleic a ... | 1995 | 8520105 |
| protective and therapeutic effects of curcuma xanthorrhiza on hepatotoxin-induced liver damage. | curcuma xanthorrhiza roxb. (zingiberaceae family, commonly known as temu lawak or javanese turmeric in indonesia), which is found both wild and cultivated in indonesia, has been traditionally used for medicinal purposes. c. xanthorrhiza is also used as a tonic in indonesia. the aim of the present study is to clarify whether c. xanthorrhiza treatment may prevent acute liver damage induced by acetaminophen and carbon tetrachloride in mice. the results clearly indicated that extract of c. xanthorrh ... | 1995 | 8571920 |
| mutagenicity and anti-mutagenicity of selected spices. | using salmonella typhimurium strains ta 100 and ta 1535, the mutagenicity and anti-mutagenicity of extracts of several spices were checked. spices like pepper, pippali, ginger and mustard increased the number of revertants indicating their mutagenic potential. garlic extract on the other hand was found to inhibit the mutagenicity produced by direct acting mutagens such as n-methyl n'-nitro-n-nitrosoguanidine and sodium azide. asafoetida and turmetic extract were found to inhibit microsomal activ ... | 1995 | 8582746 |
| effect of curcumin and eugenol on iron-induced hepatic toxicity in rats. | male wistar rats injected i.p. with 30 mg fe2+/kg body weight show hepatic damage as measured by an increase in lipid peroxides which correlated with elevated serum enzymes, alanine aminotransferase (alat), aspartate aminotransferase (asat) and lactate dehydrogenase (ldh). oral administration of spice principles, curcumin from turmeric (30 mg/kg body weight) or eugenol from cloves (100 mg/kg body weight), for 10 days lowered the liver and serum lipid peroxide levels, serum alat, asat and ldh, en ... | 1996 | 8597030 |
| inhibition of 7,12-dimethylbenz[a]anthracene (dmba)-induced mammary tumorigenesis and dmba-dna adduct formation by curcumin. | curcumin, a constituent of the traditional indian spice and medicine turmeric, was evaluated for its capacity to inhibit the mammary tumor initiating activity of 7,12-dimethylbenz[a]anthracene (dmba) and the in vivo formation of mammary dmba-dna adducts in the female rat. administration (i.p.) of curcumin at 100 mg/kg and 200 mg/kg doses was associated with a significant decrease in the number of palpable mammary tumors and mammary adenocarcinomas. the in vivo formation of mammary dmba-dna adduc ... | 1996 | 8635149 |
| diet, nutrition & cancer--the indian scenario. | cancer continues to be a major health problem despite advances in medical technology for its diagnosis and treatment. hence prevention strategies are needed to decrease the burden of the disease. of all the environmental factors, dietary components appear to play an important role in the initiation/progression of the disease. nutrients and non-nutrients in the diet can influence the carcinogenic process at various stages, from initiation to overt manifestation. the national institute of nutritio ... | 1995 | 8675239 |
| determination of selected trace elements in foodstuffs and biological materials by destructive neutron activation analysis. | concentration of trace elements in nescafé, fariman sugar, and sadaf turmeric and mercury content in cancerous blood were determined by radiochemical, neutron activation analysis. by this separation method levels of 110mag, 198au, 203hg, 76se, 51cr, 24na, 42k, 99mo, 122sb, 82br, 59fe, 60co were measured without interference in the gamma spectroscopy. a nondestructive method has also been used for the analysis of sodium, potassium, and bromine. | 2000 | 8748216 |
| inhibitory effect of spices on in vitro histamine production and histidine decarboxylase activity of morganella morganii and on the biogenic amine formation in mackerel stored at 30 degrees c. | the inhibitory effects of clove, cinnamon, cardamom, turmeric and pepper on the histamine production and histidine decarboxylase activity of morganella morganii (a potent histamine-producing bacteria in fish) was examined at 30 degrees c using hplc. cinnamon and clove exhibited a significant (p < 0.01) inhibitory effect, whereas turmeric and cardamom had a moderate effect. these spices were applied to whole mackerel at a level of 3% and their inhibitory effect on biogenic amine formation at 30 d ... | 1996 | 8765991 |
| inhibition of cyclic amp-dependent protein kinase by curcumin. | curcumin [diferuloylmethane; 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione], a major bioactive secondary metabolite found in the rhizomes of turmeric (curcuma longa), is an inhibitor of ca(2+)- and phospholipid-dependent protein kinase c (pkc) and of the catalytic subunit (cak) of cyclic amp-dependent protein kinase (ic50 values 15 and 4.8 microm, respectively). curcumin inhibits plant ca(2+)-dependent protein kinase (cdpk) (ic50 41 microm), but does not inhibit myosin light chain ... | 1996 | 8768315 |
| antifungal activity of turmeric oil extracted from curcuma longa (zingiberaceae). | turmeric oil and curcumin, isolated from curcuma longa l., were studied against fifteen isolates of dermatophytes, four isolates of pathogenic molds and six isolates of yeasts. the inhibitory activity of turmeric oil was tested in trichophyton-induced dermatophytosis in guinea pigs. the results showed that all 15 isolates of dermatophytes could be inhibited by turmeric oil at dilutions of 1:40-1:320. none of the isolates of dermatophytes were inhibited by curcumin. the other four isolates of pat ... | 1995 | 8824742 |
| antimutagenic and anticarcinogenic activity of natural and synthetic curcuminoids. | five synthetic curcuminoids and three natural curcuminoids were investigated for their antimutagenic and anti-promotional activity. the natural curcuminoids, curcumin i (diferuloylmethane), curcumin ii (feruloyl-p-hydroxycinnamoylmethane) and curcumin iii (bis-(p-hydroxycinnamoyl)methane) isolated from curcuma longa were found to be potent inhibitors of mutagenesis and crotean oil-induced tumour promotion. curcumin iii produced 87.6% inhibition to 2-acetamidofluorene (2-aaf) induced mutagenesis, ... | 1996 | 8879271 |
| curcumin protects against 4-hydroxy-2-trans-nonenal-induced cataract formation in rat lenses. | age-related cataractogenesis is a significant health problem worldwide. oxidative stress has been suggested to be a common underlying mechanism of cataractogenesis, and augmentation of the antioxidant defenses of the ocular lens has been shown to prevent or delay cataractogenesis. the present studies were designed to test the efficacy of curcumin, an antioxidant present in the commonly used spice turmeric, in preventing cataractogenesis in an in vitro rat model. rats were maintained on an ain-76 ... | 1996 | 8901798 |
| curcumin inhibits the proliferation and cell cycle progression of human umbilical vein endothelial cell. | we have studied the effect of curcumin (diferuloylmethane), a major component of the food flavor turmeric, on the proliferation and cell cycle progression of human umbilical vein endothelial cells (huvec). curcumin inhibited the dna synthesis of huvec as revealed by [3h]thymidine incorporation in a dose-dependent manner without significantly affecting the viability of the cells. the growth of huvec stimulated with fibroblast growth factor (fgf) and endothelial growth supplement (ecgs) was also i ... | 1996 | 8913274 |
| induction of hsp70 gene expression by modulation of ca(+2) ion and cellular p53 protein by curcumin in colorectal carcinoma cells. | curcumin (diferuloyl methane) is the major active yellow pigment of turmeric and curry. studies in recent years have indicated that curcumin is a potent inhibitor of the initiation and promotion of chemical carcinogen-induced skin carcinogenesis in mice. when colo205 colorectal carcinoma cells were treated with curcumin (60 microm), the appearance of apoptotic dna ladders was delayed about 5 h, and g1 arrest was detected. further analysis of the endonuclease activities in these cells revealed th ... | 1996 | 8989916 |
| enhancing effect of ultraviolet a on ornithine decarboxylase induction and dermatitis evoked by 12-o-tetradecanoylphorbol-13-acetate and its inhibition by curcumin in mouse skin. | previous studies have demonstrated appreciable tumor induction in mouse skin by daily irradiation with high-power long-wavelength ultraviolet a (uva). | 1996 | 8993955 |
| effect of plant extracts and systemic fungicide on the pineapple fruit-rotting fungus, ceratocystis paradoxa. | antifungal activities of extracts of sixteen plants were tested against ceratocystis paradoxa which causes soft rot of pineapples. xanthium strumarium was the most effective followed by allium sativum. the effectiveness of various extracts against c. paradoxa was in the decreasing order of meriandra bengalensis, mentha piperita, curcuma longa, phlogacanthus thyrsiflorus, toona ciliata, vitex negundo, azadirachta indica, eupatorium birmanicum, ocimum sanctum and leucas aspera. extracts of cassia ... | 1996 | 9022263 |
| hypolipidemic action of curcumin, the active principle of turmeric (curcuma longa) in streptozotocin induced diabetic rats. | streptozotocin-induced diabetic rats were maintained on 0.5% curcumin containing diet for 8 weeks. blood cholesterol was lowered significantly by dietary curcumin in these diabetic animals. cholesterol decrease was exclusively from ldl-vldl fraction. significant decrease in blood triglyceride and phospholipids was also brought about by dietary curcumin in diabetic rats. in a parallel study, wherein diabetic animals were maintained on a high cholesterol diet, the extents of hypercholesterolemia a ... | 1997 | 9046034 |
| inhibitory effects of topical application of low doses of curcumin on 12-o-tetradecanoylphorbol-13-acetate-induced tumor promotion and oxidized dna bases in mouse epidermis. | the effects of topical applications of very low doses of curcumin (the major yellow pigment in turmeric and the indian food curry) on 12-o-tetradecanoylphorbol-13-acetate (tpa)-induced oxidation of dna bases in the epidermis and on tumor promotion in mouse skin were investigated. cd-1 mice were treated topically with 200 nmol of 7,12-dimethylbenz[a]anthracene followed one week later by 5 nmol of tpa alone or together with 1, 10, 100 or 3000 nmol of curcumin twice a week for 20 weeks. curcumin-me ... | 1997 | 9054592 |
| allergic contact dermatitis from curcumin (turmeric). | 1997 | 9062750 | |
| presence of an acidic glycoprotein in the serum of arthritic rats: modulation by capsaicin and curcumin. | levels of various serum proteins were found to change in adjuvant induced arthritis. increased levels of a glycoprotein with an apparent molecular weight of 72 kda (gp a72) were observed in the sera of arthritic rats. gp a72 is an acidic glycoprotein with a pi of 5.1. gp a72 also showed antitryptic activity. the appearance of gp a72 in the serum preceded the onset of paw inflammation in arthritic rats and persisted in the chronic phase. oral administration of the antiinflammatory spice principle ... | 1997 | 9089639 |
| protective effect of food additives on aflatoxin-induced mutagenicity and hepatocarcinogenicity. | food additives such as turmeric (curcuma longa), and active ingredient curcumin (diferuloyl methane), asafoetida (flavouring agent), butylated hydroxyanisole (bha), butylated hydroxytoluene (bht) and ellagic acid were found to inhibit the mutagenesis induced by aflatoxin b1 (afb1) (0.5 microg/plate) in salmonella tester strains ta 98 and ta 100. turmeric and curcumin, which were the most active, inhibited mutation frequency by more than 80% at concentrations of 2 microg/plate. other food additiv ... | 1997 | 9149115 |
| curcumin and genistein, plant natural products, show synergistic inhibitory effects on the growth of human breast cancer mcf-7 cells induced by estrogenic pesticides. | curcumin and genistein are two natural products of plants obtained from curcuma longa linn (turmeric) and soybeans, respectively. both compounds when present at micromolar concentrations are able to inhibit the growth of estrogen-positive human breast mcf-7 cells induced individually or by a mixture of the pesticides endosulfane, ddt and chlordane or 17-beta estradiol. when curcumin and genistein were added together to mcf-7 cells, a synergistic effect resulting in a total inhibition of the indu ... | 1997 | 9168916 |
| antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines. | pharmacologically safe compounds that can inhibit the proliferation of tumor cells have potential as anticancer agents. curcumin, a diferuloylmethane, is a major active component of the food flavor turmeric (curcuma longa) that exhibits anticarcinogenic properties in vivo. in vitro, it suppressed c-jun/ap-1 and nf-kappab activation and type 1 human immunodeficiency virus long-terminal repeat-directed gene expression. we examined the antiproliferative effects of curcumin against several breast tu ... | 1997 | 9215611 |
| inhibitory effect of dietary curcumin on skin carcinogenesis in mice. | laboratory animal model studies have suggested that curcumin may play an important role in inhibiting the process of carcinogenesis. curcumin, the yellow pigment that is obtained from rhizomes of the plant curcuma longa linn (family zingiberaceae), is commonly used as a spice and food coloring agent. the present study was designed to investigate the chemopreventive action of dietary curcumin on 7,12-dimethylbenz[a]anthracene (dmba)-initiated and 12-o-tetradecanoylphorbol-13-acetate (tpa)-promote ... | 1997 | 9215864 |
| effect of turmeric oil and turmeric oleoresin on cytogenetic damage in patients suffering from oral submucous fibrosis. | in vitro studies on the effect of alcoholic extracts of turmeric (te), turmeric oil (to) and turmeric oleoresin (tor), on the incidence of micronuclei (mn) in lymphocytes from normal healthy subjects showed that the test compounds did not cause any increase in the number of mn as compared with those found in untreated controls. further it was observed that all three compounds offered protection against benzo[a]pyrene induced increase in mn in circulating lymphocytes. in subsequent studies, patie ... | 1997 | 9215873 |
| protective effect of curcuminoids on epidermal skin cells under free oxygen radical stress. | curcuminoids from curcuma longa l. (zingiberaceae) protected normal human keratinocytes from hypoxanthine/ xanthine oxidase injury. since curcuminoids synergistically inhibited nitroblue tetrazolium reduction, a decrease in superoxide radical formation leading to lower levels of cytotoxic hydrogen peroxide was proposed as an explanation for this protective effect. | 1997 | 9225611 |
| inhibitory effects of curcumin-free aqueous turmeric extract on benzo[a]pyrene-induced forestomach papillomas in mice. | the modulating effects of curcumin-free aqueous turmeric extract (cfate), ethanolic turmeric extract (ete) and turmeric (t) powder on the benzo(a)pyrene (b(a)p)-induced forestomach tumors were investigated in swiss female albino mice receiving oral administration of b(a)p at a dose of 1 mg twice weekly for 4 weeks. administration of 0.2%/1.0%/5.0% turmeric-derived cfate as sole source of drinking water or 0.01%/0.05%/0.25% ete in diet or 0.2%/1.0%/5.0% t in diet, 2 weeks before, during and 2 wee ... | 1997 | 9310263 |
| influence of retinol deficiency and curcumin/turmeric feeding on tissue microsomal membrane lipid peroxidation and fatty acids in rats. | the effect of retinol deficiency and curcumin/turmeric on lipid peroxidation and fatty acid profile was studied in liver, kidney, spleen and brain microsomes of rats. results revealed an increase in lipid peroxidation in retinol deficient liver by 32%, kidney 30%, spleen 24% and brain 43% compared to the controls. feeding 0.1% curcumin or turmeric for three weeks in diet to retinol deficient rats reduced the lipid peroxidation respectively to 12.5 or 22.6%, in liver, 23.7 or 24.1% in kidney, 14. ... | 1997 | 9350032 |
| inhibition of proliferation and apoptosis of human and rat t lymphocytes by curcumin, a curry pigment. | curcumin (diferuoylmethane), the yellow pigment in the rhizome of tumeric (curcuma longa), an ingredient of curry spice, is known to exhibit a variety of pharmacological effects including antitumor, antiinflammatory, and antiinfectious activities. although its precise mode of action remains elusive, curcumin has been shown to suppress the activity of the ap-1 transcription factor in cells stimulated to proliferate. in this study, we observed that curcumin (50 microm) inhibited proliferation of r ... | 1997 | 9354590 |
| free radical reactions of curcumin in membrane models. | free radical reactions of curumin, a lipid soluble antioxidant from turmeric (curcuma longa), have been studied with a variety of oxidants using tx 100 micelle as a model membrane. the phenoxyl radicals of curcumin generated by one electron oxidizing azide radicals in acetonitrile-water mixture and tx 100 micelles show very similar spectral behavior. however, in membrane models the radical lifetimes and the molar extinction coefficients are significantly different from the homogeneous solutions. ... | 1997 | 9378362 |
| inhibitory effect on curcumin on mammalian phospholipase d activity. | curcumin, the major yellow pigment of turmeric (curcuma longa), has strong anti-carcinogenic and anti-inflammatory activities. we examined the effects of curcumin on enzyme activities of the following phospholipases in a cell-free system: g protein-mediated phospholipase d (pld), phosphatidylinositol-specific phospholipase c, and phospholipase a2 from mouse macrophage-like cell line j774.1 cells, sphingomyelinase from bovine brain, and phosphatidylcholine-phospholipase c from bacillus cereus. cu ... | 1997 | 9395294 |
| effect of curcumin and capsaicin on arachidonic acid metabolism and lysosomal enzyme secretion by rat peritoneal macrophages. | the inflammatory mediators secreted by macrophages play an important role in autoimmune diseases. spice components, such as curcumin from turmeric and capsaicin from red pepper, are shown to exhibit antiinflammatory properties. the influence of these spice components on arachidonic acid metabolism and secretion of lysosomal enzymes by macrophages was investigated. rat peritoneal macrophages preincubated with 10 microm curcumin or capsaicin for 1 h inhibited the incorporation of arachidonic acid ... | 1997 | 9397403 |
| curcumin, a natural plant phenolic food additive, inhibits cell proliferation and induces cell cycle changes in colon adenocarcinoma cell lines by a prostaglandin-independent pathway. | curcumin, the active ingredient of the rhizome of the plant turmeric (curcuma longa linn), a commonly used spice, prevents cancer in animal tumor models. its mechanism of action is unknown; curcumin may act by inhibiting arachidonic acid metabolism. to explore the mechanism of curcumin's chemopreventive effect, we studied its role in proliferation and apoptosis in the ht-29 and hct-15 human colon cancer cell lines. curcumin dose-dependently reduced the proliferation rate of both cell lines, caus ... | 1997 | 9422331 |
| curcuma longa: culinary turmeric. | 1997 | 9422340 | |
| effect of turmeric, turmerin and curcumin on h2o2-induced renal epithelial (llc-pk1) cell injury. | cell injury by oxidative stress is an important mechanism for renal epithelial cell destruction. this study observed the protective effect of turmeric and its constituents on h2o2-induced injury. turmeric consists of a water soluble turmerin and lipid soluble curcumin with potent antioxidant properties. confluent llc-pk1 cells were labelled with 3h-arachidonic acid at 0.1 microci/ml over 18 h and then further labelled with 51cr. turmeric ( 100 microg/ml-0.1 microg/ml), turmerin (800 ng/ml-0.8 ng ... | 1998 | 9436613 |
| the effect of curcumin on human b-cell immortalization by epstein-barr virus. | cyclosporine is a commonly used immunosuppressant in solid-organ transplantation. it is, however, associated with an increased incidence of epstein-barr virus (ebv)induced post-transplant lymphoproliferative disorder (ptld). in this study, human b lymphocytes isolated from healthy volunteers were immortalized in vitro with ebv. the effect of oxidative stress mediated by cyclosporine a or hydrogen peroxide on in vitro b cell immortalization was studied by coculturing immortalized b cells with cyc ... | 1998 | 9457037 |
| chemopreventive efficacy of curcumin-free aqueous turmeric extract in 7,12-dimethylbenz[a]anthracene-induced rat mammary tumorigenesis. | the modulating effects of turmeric (t), ethanolic turmeric extract (ete) and curcumin-free aqueous turmeric extract (cfate) on the initiation or post-initiation phases of dmba-induced mammary tumorigenesis were investigated in female sprague-dawley rats. dietary administration of 1% t/0.05% ete 2 weeks before, on the day of dmba treatment (day 55) and 2 weeks after the single dose (15 mg/animal) of dmba (during the initiation period) resulted in significant suppression of dmba-induced mammary tu ... | 1998 | 9461015 |
| studies on the anticlastogenic effect of turmeric and curcumin on cyclophosphamide and mitomycin c in vivo. | turmeric and its main constituent curcumin were assessed in vivo for their anticlastogenic potential. in one experimental set, swiss albino male mice were given turmeric (8, 12 and 16 mg/kg body weight) or curcumin (2, 4 and 8 mg/kg body weight) as a single intraperitoneal injection. in another set, the mice were given 8 mg/kg body weight of turmeric or one of three concentrations of curcumin (2, 4 and 8 mg/kg body weight) as a dietary supplement by gavage for 7 consecutive days. 30 min after th ... | 1998 | 9487365 |
| strand scission in dna induced by curcumin in the presence of cu(ii). | curcumin, a naturally occurring phytochemical responsible for the colour of turmeric, has shown a wide range of pharmacological properties including anti-inflammatory, anti-tumour promoter and anti-oxidant effects. in this paper we show that in the presence of cu(ii), curcumin caused breakage of calf thymus and supercoiled plasmid pbr322 dna. the products were relaxed circles with no detectable linear forms. other metal ions tested (mg(ii), ca(ii), fe(ii) and ni(ii)) were ineffective or less eff ... | 1998 | 9500187 |
| quantitation of chemopreventive synergism between (-)-epigallocatechin-3-gallate and curcumin in normal, premalignant and malignant human oral epithelial cells. | an in vitro model for oral cancer was used to examine the growth inhibitory effects of chemopreventive agents when used singly and in combination. the model consists of primary cultures of normal oral epithelial cells, newly established cell lines derived from dysplastic leukoplakia and squamous cell carcinoma. two naturally occurring substances, (-)-epigallocatechin-3-gallate (egcg) from green tea and curcumin from the spice turmeric were tested. cells were treated singly and in combination and ... | 1998 | 9525275 |
| detection of antitumor promoting activity in raji cells carrying epstein-barr virus genome by immunoblotting analysis. | extract of raji cells treated with sodium n-butyrate (1 mm) and a tumor promoter, 12-o-tetradecanoylphorbol-13-acetate (tpa, 40 ng/ml), was analyzed by immunoblotting using ten human sera with different antibody titers against epstein-barr virus early antigens. two human sera reacted with one induced polypeptide of 48 kda and its induction was inhibited by curcumin (4 micrograms/ml), an antitumor promoter from turmeric. a mouse antiserum against p3hr-1 cells treated with tpa and sodium n-butyrat ... | 1998 | 9532799 |
| curcumin and curcumin derivatives inhibit tat-mediated transactivation of type 1 human immunodeficiency virus long terminal repeat. | the transcription of hiv1 provirus is regulated by both cellular and viral factors. various evidence suggests that tat protein secreted by hiv1-infected cells may have additional action in the pathogenesis of aids because of its ability to also be taken up by non-infected cells. curcumin [diferuloylmethane or 1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] is the yellow pigment in turmeric curcuma longa (linn). it exhibits a variety of pharmacological effects including antiinflamma ... | 1998 | 9561563 |
| amelioration of renal lesions associated with diabetes by dietary curcumin in streptozotocin diabetic rats. | curcumin, the coloring principle of the commonly used spice turmeric (curcuma longa) was fed at 0.5% in the diet to streptozotocin-induced diabetic wistar rats for 8 weeks. renal damage was assessed by the amount of proteins excreted in the urine and the extent of leaching of renal tubular enzymes: nag, ldh, asat, alat, alkaline and acid phosphatases. the integrity of kidney was assessed by measuring the activities of several key enzymes of the renal tissue: glucose-6-phosphate dehydrogenase, gl ... | 1998 | 9562245 |
| novel bioactivities of curcuma longa constituents. | bioassay-directed fractionation of ethyl acetate extract from curcuma longa linn. rhizomes yielded three curcuminoids, which displayed topoisomerase i and ii enzyme inhibition activity. curcumin iii (3) was the most active curcuminoid, inhibiting topoisomerase at 25 micrograms ml-1. curcumin i (1) and curcumin ii (2) inhibited the topoisomerases at 50 micrograms ml-1. fractionation of the volatile oil from the rhizomes afforded ar-turmerone (4), which displayed mosquitocidal activity with an ld1 ... | 1998 | 9584408 |
| retardation of experimental tumorigenesis and reduction in dna adducts by turmeric and curcumin. | turmeric and its active principle curcumin have been extensively investigated for their antimutagenic and antioxidant effects in bacterial and animal systems. because oral cancers are common in india, an experimental model of 7,12-dimethylbenzanthracene-induced buccal pouch tumors in syrian golden hamsters was used to evaluate the tumor retardation effects of turmeric and curcumin. turmeric and/or curcumin was administered in the diet and/or applied locally for 14 weeks along with 7,12-dimethylb ... | 1998 | 9589436 |
| inhibitory effects of curcumin on tumorigenesis in mice. | curcumin (diferuloylmethane), the naturally occurring yellow pigment in turmeric and curry, is isolated from the rhizomes of the plant curcuma longa linn. curcumin inhibits tumorigenesis during both initiation and promotion (post-initiation) periods in several experimental animal models. topical application of curcumin inhibits benzo[a]pyrene (b[a]p)-mediated formation of dna-b[a]p adducts in the epidermis. it also reduces 12-o-tetradecanoylphorbol-13-acetate (tpa)-induced increases in skin infl ... | 1997 | 9591190 |
| influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. | the medicinal properties of curcumin obtained from curcuma longa l. cannot be utilised because of poor bioavailability due to its rapid metabolism in the liver and intestinal wall. in this study, the effect of combining piperine, a known inhibitor of hepatic and intestinal glucuronidation, was evaluated on the bioavailability of curcumin in rats and healthy human volunteers. when curcumin was given alone, in the dose 2 g/kg to rats, moderate serum concentrations were achieved over a period of 4 ... | 1998 | 9619120 |
| the effect of environmental factors on elastomeric chain and nickel titanium coil springs. | it is well known that elastomers exhibit viscoelasticity and as such have their mechanical properties modified by temperature. nickel titanium archwires are also affected by temperature and have been modified with specific temperature related properties for clinical use. what is less well known is the effect that other environmental factors, such as food, might have on the force delivery properties of both elastomeric materials and nickel titanium coil springs used for space closure. for instanc ... | 1998 | 9633170 |
| [rules of the absorption, distribution and translocation of nitrogen, phosphorus and potassium in turmeric plant]. | it has been found out that the percentages of nitrogen (n), phosphorus (p) and potassium (k) in turmeric plant (curcuma longa) are higher in young organs. varying with the growth stages, the nutrient contents of the plant, whose amount order is k > n > p are the highest in the seedling stage. nutrient absorption occurs mainly in the young turmeric forming stage and enriching stage. nutrient translocation takes place mainly from leaves and leaf stalks to young and old turmeric, the rate of p bein ... | 1996 | 9642404 |
| effects of curcumin on p-glycoprotein in primary cultures of rat hepatocytes. | curcumin is a natural phenolic compound found in the rhizomes of curcuma longa and endowed with beneficial biological activities including antioxidant, anticarcinogenic and hepatoprotective effects. in this study curcumin was tested for its potential ability to interact in vitro with hepatic p-glycoprotein (pgp), in a model system represented by primary cultures of rat hepatocytes, in which spontaneous overexpression of multidrug resistance (mdr) genes occurs. in both freshly-plated hepatocytes, ... | 1998 | 9651124 |
| ethnoveterinary medicines used for ruminants in trinidad and tobago. | ethnoveterinary research was conducted in trinidad and tobago in 1995, in order to document existing ethnoveterinary practices. this paper describes 20 medicinal plants used to treat ruminants. the main plants used were azadirachta indica and curcuma longa. medicinal plants were used predominantly for endoparasites, internal and external injuries and pregnancy-related conditions. a 4-stage process was used to conduct the research and document the ethnoveterinary practices. this documentation cou ... | 1998 | 9658442 |
| effect of the beta-diketones diferuloylmethane (curcumin) and dibenzoylmethane on rat mammary dna adducts and tumors induced by 7,12-dimethylbenz[a]anthracene. | curcumin is a beta-diketone constituent of the spice turmeric that possesses anticarcinogenic properties in several animal models. the present studies were conducted in order to identify beta-diketones structurally-related to curcumin that would be effective dietary blocking agents toward the initiation stage of 7,12-dimethylbenz[a]anthracene (dmba)-induced rat mammary carcinogenesis. of the beta-diketone compounds initially screened for their capacity to induce quinone-reductase (qr) activity i ... | 1998 | 9667742 |
| mechanisms of anticarcinogenic properties of curcumin: the effect of curcumin on glutathione linked detoxification enzymes in rat liver. | curcumin, an antioxidant isolated from turmeric (curcuma longa), has been shown to attenuate chemical carcinogenesis in rodents. previous studies have shown that curcumin causes an increase in glutathione s-transferase (gst) activity in rodent liver which may contribute to its anti-cancer and anti-inflammatory activities. since the effects of curcumin on specific gst isozymes and other glutathione (gsh)-linked enzymes are incompletely defined, we have examined in the present studies the effect o ... | 1998 | 9675878 |
| an ethanolic-aqueous extract of curcuma longa decreases the susceptibility of liver microsomes and mitochondria to lipid peroxidation in atherosclerotic rabbits. | atherosclerosis is characterized by oxidative damage which affects lipoproteins, the walls of blood vessels and subcellular membranes. this study evaluates the antioxidant capacity of a curcuma longa extract on the lipid peroxidation of liver mitochondria and microsome membranes in atherosclerotic rabbits. male rabbits fed a 3% (w/w) lard and 1.3% (w/w) cholesterol diet were randomly assigned to three groups. two groups were treated with different dosages of a turmeric extract (a and b) and the ... | 1998 | 9699009 |
| subchronic oral toxicity of turmeric and ethanolic turmeric extract in female mice and rats. | subchronic oral toxicity of turmeric and ethanolic turmeric extract was studied in female swiss mice and wistar rats fed turmeric (0, 1 and 5%) and ethanolic turmeric extract (0, 0.05 and 0.25%) through diet for 14 and/or 90 days. the administration of a high dose of turmeric (5%) for longer duration (90 days) showed a significant reduction in body weight gain, alterations in absolute and/or relative liver weights, and hepatotoxicity i.e. focal necrosis or focal necrosis with regeneration both i ... | 1998 | 9704820 |
| inhibitory effect of curcuminoids on mcf-7 cell proliferation and structure-activity relationships. | curcumin, demethoxycurcumin and bisdemethoxycurcumin are the yellow coloring phenolic compounds isolated from the spice turmeric. this study was part of a program correlating the biological activity and molecular structure of antitumor agents; the effect of these curcuminoids and cyclocurcumin (cyclocur) was examined on the proliferation of mcf-7 human breast tumor cells. curcuminoids appeared to be potent inhibitors, whereas cyclocur was less inhibitory. to contribute to our understanding of th ... | 1998 | 9714342 |
| effect of curcumin on cell cycle progression and apoptosis in vascular smooth muscle cells. | 1. the possible mechanisms of the antiproliferative and apoptotic effects of curcumin (diferuloylmethane), a polyphenol in the spice turmeric, on vascular smooth muscle cells were studied in rat aortic smooth muscle cell line (a7r5). 2. the proliferative response was determined from the uptake of [3h]-thymidine. curcumin (10(-6)-10(-4) m) inhibited serum-stimulated [3h]-thymidine incorporation of both a7r5 cells and rabbit cultured vascular smooth muscle cells in a concentration-dependent manner ... | 1998 | 9720770 |
| protective effect of turmeric (curcuma longa l.) extract on carbon tetrachloride-induced liver damage in rats. | the protective effect of tumeric extract (te) in diet on ccl4-treated rats was studied. rats were divided into 5 groups: (1) untreated, (2) ccl4 treated, (3) pre-te for 2 weeks followed by ccl4, (4) te + ccl4 given concurrently and (5) 5% te as positive control. the serum levels of bilirubin, cholesterol, aspartate aminotransferase, (ast), alanine amino transferase (ast), (alt) and alkaline phosphatase were estimated after 1, 2 and 3 months. ccl4 caused a maximum increase (2-3-fold in all the ab ... | 1998 | 9731471 |
| curcumin blocks cyclosporine a-resistant cd28 costimulatory pathway of human t-cell proliferation. | curcumin (cur) is a phenolic component of common spice, turmeric. we have reported earlier that it possesses antineoplastic and immunosuppressive properties in vitro. it has been reported that cyclosporine a (cya), a commonly used immunosuppressant does not inhibit cd28 costimulatory pathway of t-cell activation. we hypothesized that cur, a tyrosine kinase inhibitor, would block cya-resistant cd28 costimulatory pathway of human t cell proliferation. | 1998 | 9733605 |
| mechanism of inhibition of benzo[a]pyrene-induced forestomach cancer in mice by dietary curcumin. | curcumin (diferuloylmethane), the major yellow pigment in turmeric, has been shown to inhibit benzo[a]pyrene (bap)-induced forestomach cancer in mice through mechanism(s) not fully understood. it is well known that while cytochrome p4501a1 (cyp1a1) and epoxide hydrolase (eh) are important in the conversion of bap to its activated form, (+)-anti-7,8-dihydroxy-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene [(+)-anti-bapde], the detoxification of (+)-anti-bapde is accomplished by glutathione (gsh) s-tr ... | 1998 | 9744529 |
| suppression of mouse skin tumor promotion and induction of apoptosis in hl-60 cells by alpinia oxyphylla miquel (zingiberaceae). | there have been considerable efforts to search for naturally occurring substances for the intervention of carcinogenesis. many components from dietary or medicinal plants have been identified that possess substantial chemopreventive properties. an example is curcumin (curcuma longa linn., zingiberaceae), which has been shown to inhibit tumor promotion in experimental carcinogenesis. alpinia oxyphylla miquel, another plant of the ginger family used in oriental herbal medicine, contains diarylhept ... | 1998 | 9744532 |
| stimulation of the stress-induced expression of stress proteins by curcumin in cultured cells and in rat tissues in vivo. | curcumin, a major component of turmeric, a seasoning commonly used in indian food, and a known antioxidant, anti-inflammatory and anti-carcinogenic agent, is a potent stimulator of the stress-induced expression of hsp27, alphab crystallin and hsp70. when c6 rat glioma cells were exposed to arsenite (100 microm for 1 h), cdcl2 (100 microm for 1 h) or heat (42 degrees c for 30 min) in the presence of 3-10 microm curcumin, induction of the synthesis of all three proteins was markedly stimulated, as ... | 1998 | 9764755 |
| [curcuma longa l. tuber yield simulation model and its application under combined agronomic measures for good-quality, high-yield and obvious economic results]. | a design of second order orthogonal rotative regression was developed and field tested, and the tuber models for yield, quality and benefit were simulated and built. the effect of agronomic measures on the tuber yield is plant density > phosphorus > sowing date > nitrogen > potassium. there is a clear interrelation effect among agronomic measures. the results of simulation experiment have shown that the optimal combination of farming practices can greatly increase the tuber yield, quality and be ... | 1996 | 9772639 |
| enhancement of wound healing by curcumin in animals. | tissue repair and wound healing are complex processes that involve inflammation, granulation, and remodeling of the tissue. in this study, we evaluated the in vivo effects of curcumin (difeurloylmethane), a natural product obtained from the rhizomes of curcuma longa on wound healing in rats and guinea pigs. we observed faster wound closure of punch wounds in curcumin-treated animals in comparison with untreated controls. biopsies of the wound showed reepithelialization of the epidermis and incre ... | 1998 | 9776860 |
| subchronic oral hepatotoxicity of turmeric in mice--histopathological and ultrastructural studies. | dietary administration of the whole spice turmeric (0.2%, 1.0%, 5.0%) or ethanolic turmeric extract (ete, 0.05%, 0.25%) for 14 days, at doses reported to be cancer preventive in model systems, were found to be hepatotoxic in mice. histopathological evaluation showed coagulative necrosis accompanied by a zone of regenerating parenchymal cells of liver. the ultrastructural changes in liver parenchymal cells were non-specific reaction to injury. results suggest mouse to be a susceptible species for ... | 1998 | 9782784 |
| [effect of organic fertilizer and mineral fertilizer on the tuber yield of curcuma longa l]. | regression method of orthogonal conic substitution with factors was employed to build up the tuber models for yield, quality and benefit. three main measures affecting the tuber yield, quality and benefit were analyzed by these mathematical models. the effect of agronomic measures on the tuber yield is human and livestock excreta, rape cake > ca3(po4)2 > kcl. the optimal combination of farming practices has been obtained according to the analysis of these models. | 1996 | 9812688 |
| bioactive phytochemicals with emphasis on dietary practices. | diet can modify the pathophysiological processes of various metabolic disorders and can be an effective preventive strategy for various disease processes most of which are known to involve oxidative damage. both nutrient and non-nutrient components of the diet have been recognized for their anti-oxidant and other potential benefits. plant foods contain phytochemicals such as flavonoids, phenolic acids, etc., which show biological activity. some common foods used in indian culinary practices were ... | 1998 | 9863273 |
| inhibition of lipoxygenase 1 by phosphatidylcholine micelles-bound curcumin. | curcumin (diferuloyl methane) from rhizomes of curcuma longa l. binds to phosphatidylcholine (pc) micelles. the binding of curcumin with pc micelles was followed by fluorescence measurements. curcumin emits at 490 nm with an excitation wavelength of 451 nm after binding to pc-mixed micelles stabilized with deoxycholate. curcumin in aqueous solution does not inhibit dioxygenation of fatty acids by lipoxygenase 1 (lox1). but, when bound to pc micelles, it inhibits the oxidation of fatty acids. the ... | 1998 | 9930409 |
| chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer. | curcumin, derived from the rhizome of curcuma longa l. and having both antioxidant and anti-inflammatory properties, inhibits chemically induced carcinogenesis in the skin, forestomach, and colon when it is administered during initiation and/or postinitiation stages. this study was designed to investigate the chemopreventive action of curcumin when it is administered (late in the premalignant stage) during the promotion/progression stage of colon carcinogenesis in male f344 rats. we also studied ... | 1999 | 9973206 |
| antitumor activity of curcumin is mediated through the induction of apoptosis in ak-5 tumor cells. | curcumin, the yellow pigment of turmeric (curcuma longa), used commonly as a spice, has been shown to possess anticarcinogenic activity. curcumin inhibited ak-5 tumor growth and induced apoptosis in ak-5 cells. curcumin induced apoptosis is mediated through the activation of caspase-3, which is specifically inhibited by the tetrapeptide ac-devd-cho. in addition, curcumin induced tumor cell death is caused through the generation of reactive oxygen intermediates which is inhibited by n-acetyl-l-cy ... | 1999 | 10069393 |
| modulation of radioresponse of glyoxalase system by curcumin. | human beings have been exposed to radiation for many years. it is quite possible that antioxidant phytochemicals consumed in their diet might be providing a variable degree of radioprotection. however, their radiomodifying ability is not well understood. in the present work, curcumin (diferuloyl methane), a phytochemical present in the rhizome of curcuma longa linn. has been examined for its radioprotective property using the glyoxalase system which is vital for various biological functions. cur ... | 1999 | 10075116 |
| dietary curcumin with cisplatin administration modulates tumour marker indices in experimental fibrosarcoma. | curcumin, the active constituent of curcuma longa, which itself possesses antitumour activity against experimental tumours, enhances the antitumour effect of the widely used anticancer drug cisplatin, when used in combination against fibrosarcoma. tumour marker enzymes such as aminotransferases, lactate dehydrogenase, gamma-glutamyl transpeptidase, alkaline phosphatase, 5'-nucleotidase were analysed in liver and kidney homogenates of experimental rats. all these enzyme activities were markedly i ... | 1999 | 10094841 |
| biotransformation of curcumin through reduction and glucuronidation in mice. | curcumin, the yellow pigment in turmeric and curry, has antioxidative and anticarcinogenic activities. in this study, we investigated the pharmacokinetic properties of curcumin in mice. after i.p. administration of curcumin (0.1 g/kg) to mice, about 2.25 microg/ml of curcumin appeared in the plasma in the first 15 min. one hour after administration, the levels of curcumin in the intestines, spleen, liver, and kidneys were 177.04, 26.06, 26.90, and 7.51 microg/g, respectively. only traces (0.41 m ... | 1999 | 10101144 |
| potentiation by turmeric and curcumin of gamma-radiation-induced chromosome aberrations in chinese hamster ovary cells. | the effect of turmeric and curcumin, two natural antioxidants, on the frequencies of chromosome aberrations induced in chinese hamster ovary (cho) cells by gamma-radiation was investigated. cells were treated with three concentrations of each drug, turmeric (100, 250, and 500 microg/ml) and curcumin (2.5, 5, and 10 microg/ml), and then irradiated (2.5 gy) during different phases of the cell cycle. turmeric was not clastogenic by itself, whereas curcumin at 10 microg/ml enhanced the chromosomal d ... | 1999 | 10321406 |
| investigation of the effects of selected medicinal plants on experimental thrombosis. | six medicinal plants indigenous to africa were evaluated for their activity on experimental thrombosis in mice. of the plants screened, the extract of commiphora molmol exhibited the strongest antithrombotic activity, while the extract of ageratum conyzoides showed no marked activity. this study established the antithrombotic effect of the extracts of azadiractha indica, bridelia ferruginea, commiphora molmol, garcinia kola and curcuma longa. | 1999 | 10353165 |
| a review of plants used in the treatment of liver disease: part two. | botanical medicines have been used traditionally by herbalists and indigenous healers worldwide for the prevention and treatment of liver disease. clinical research in this century has confirmed the efficacy of several plants in the treatment of liver disease, while basic scientific research has uncovered the mechanisms by which some plants provide their therapeutic effects. this article is part two in a review of botanicals used in the treatment of liver disease. curcuma longa (turmeric), camel ... | 1999 | 10383482 |
| a diacetylenic spiroketal enol ether epoxide, al-1, from artemisia lactiflora inhibits 12-o-tetradecanoylphorbol-13-acetate-induced tumor promotion possibly by suppression of oxidative stress. | the inhibitory effects of the diacetylenic spiroketal enol ether epoxide al-1 from artemisia lactiflora on a variety of tumor promoter-induced biological responses such as oxidative stress as well as tumor promotion in icr mouse skin were investigated. al-1 inhibited tpa-induced intracellular peroxide formation in differentiated hl-60 cells, suggesting that this suppression might be attributable to the inhibition of o2- generation. in a double tpa application system in mouse skin, double pretrea ... | 1999 | 10403539 |
| efficacy of curcumin in the management of chronic anterior uveitis. | curcumin, obtained from rhizomes of curcuma longa, was administered orally to patients suffering from chronic anterior uveitis (cau) at a dose of 375 mg three times a day for 12 weeks. of 53 patients enrolled, 32 completed the 12-week study. they were divided into two groups: one group of 18 patients received curcumin alone, whereas the other group of 14 patients, who had a strong ppd reaction, in addition received antitubercular treatment. the patients in both the groups started improving after ... | 1999 | 10404539 |
| pro-oxidant, anti-oxidant and cleavage activities on dna of curcumin and its derivatives demethoxycurcumin and bisdemethoxycurcumin. | curcumin, a naturally occurring phytochemical responsible for the colour of turmeric shows a wide range of pharmacological properties including antioxidant, anti-inflammatory and anti-cancer effects. we have earlier shown that curcumin in the presence of cu(ii) causes strand cleavage in dna through generation of reactive oxygen species, particularly the hydroxyl radical. thus, curcumin shows both antioxidant as well as pro-oxidant effects. in order to understand the chemical basis of various bio ... | 1999 | 10418962 |