| occurrence of aflatoxins and aflatoxin-producing moulds in fresh and processed meat in egypt. | a survey was carried out to detect aflatoxins and isolate aflatoxigenic moulds contaminating fresh and processed meat products. the fungal contamination was examined in 215 samples of fresh and processed meat products and 130 samples of spices used in the meat industry collected from different local companies in cairo, egypt. processed meat products such as beefburger, hot-dog, kubeba, sausage, luncheon meat had the highest count of moulds as compared with fresh and canned meat. out of 150 sampl ... | 1991 | 1778268 |
| effect of dietary curcumin and ascorbyl palmitate on azoxymethanol-induced colonic epithelial cell proliferation and focal areas of dysplasia. | curcumin, a major yellow pigment of turmeric obtained from powdered rhizomes of the plant curcuma longa linn., is commonly used as a coloring agent in foods, drugs and cosmetics. ascorbyl palmitate is a lipid soluble derivative of ascorbic acid. both curcumin and ascorbyl palmitate have antioxidant activity and are potent inhibitors of 12-o-tetradecanoyl-phorbol-13-acetate-induced tumor promotion in mouse skin. the effects of dietary curcumin and ascorbyl palmitate on azoxymethanol (aom)-induced ... | 1992 | 1611594 |
| protective single/combined treatment with betel leaf and turmeric against methyl (acetoxymethyl) nitrosamine-induced hamster oral carcinogenesis. | the inhibitory effect of oral administration of betel-leaf extract (ble) and 2 of its constituents, beta-carotene and alpha-tocopherol, as single agents or in combination with dietary turmeric on methyl(acetoxymethyl)nitrosamine (dmn-oac)-induced oral carcinogenesis in syrian hamsters was studied. dmn-oac was administered twice monthly for 6 months. the chemopreventive effect of ble or its constituents with turmeric was determined by comparing tumor incidence observed in treated groups with that ... | 1992 | 1592532 |
| turmerin: a water soluble antioxidant peptide from turmeric [curcuma longa]. | dietary spice components have been screened for their protective effect against reactive oxygen species (ros)-induced, lipid peroxide-mediated membrane and dna damage and mutagenecity. a new, water soluble, 5-kda peptide--turmerin--from turmeric (curcuma longa) has been found to be an efficient antioxidant/dna-protectant/antimutagen. turmerin forms 0.1% of the dry weight of turmeric and is obtained in a crystalline form. it is a heat stable, noncyclic peptide containing 40 amino acid residues, w ... | 1992 | 1731625 |
| the effect of spices on cholesterol 7 alpha-hydroxylase activity and on serum and hepatic cholesterol levels in the rat. | the effect of feeding curcumin, capsaicin, ginger, mustard, black pepper and cumin on cholesterol and bile acid metabolism was studied in rats. the activity of hepatic cholesterol-7 alpha-hydroxylase, the rate-limiting enzyme of bile acid biosynthesis, was significantly elevated in curcumin (turmeric), capsaicin (red pepper), ginger and mustard treated animals. the enzyme activity was comparable to controls in black pepper and cumin fed rats. serum and liver microsomal cholesterol contents were ... | 1991 | 1806542 |
| turmeric (curcuma longa)-induced reduction in urinary mutagens. | rats were fed turmeric at various levels in the diet for up to 3 months and then exposed to benzo[a]pyrene (b[a]p) or 3-methylcholanthrene (3-mc) by ip injection. urinary mutagens were detected using the salmonella typhimurium assay. turmeric fed at 0.5% and above inhibited b[a]p- and 3-mc-mediated mutagenicity. turmeric did not adversely affect the food intake, or weight gain of the rats and no histological changes were detected. these findings are significant in view of the widespread exposure ... | 1991 | 1660015 |
| studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes. | polyunsaturated fatty acids (pufa) are vulnerable to peroxidative attack. protecting pufa from peroxidation is essential to utilize their beneficial effects in health and in preventing disease. the antioxidants vitamin e, t-butylhydroxy toluene (bht) and t-butylhydroxy anisole (bha) inhibited ascorbate/fe(2+)-induced lipid peroxidation in rat liver microsomes. in addition, a number of spice principles, for example, curcumin (5-50 microm) from turmeric, eugenol (25-150 microm) from cloves and cap ... | 1992 | 1588934 |
| anticarcinogenic effects of some indian plant products. | the anticarcinogenic properties of some commonly consumed spices and leafy vegetables were investigated. the effects of feeding the plant products on the induction of squamous cell carcinomas in the stomachs of swiss mice by feeding benzo[a]pyrene(b[a]p) and on the induction of hepatomas in wistar rats by feeding 3'-methyl-4-dimethylaminoazobenzene (3'medab) were investigated. among the nine plant products tested, cumin seeds (cuminum cyminum linn) and basil leaves (ocimum sanctum linn) signific ... | 1992 | 1473788 |
| the use and efficacy of azadirachta indica adr ('neem') and curcuma longa ('turmeric') in scabies. a pilot study. | in the ayurvedha and sidha system of medicine (indian system of medicine) azadirachta indica adr ('neem') and curcuma longa ('turmeric') has been used for healing chronic ulcers and scabies. the 'neem' and 'turmeric' was used as a paste for the treatment of scabies in 814 people. in 97% of cases cure was obtained within 3 to 15 days of treatment. we find that this is a very cheap, easily available, effective and acceptable mode of treatment for the villagers in the developing countries. we have ... | 1992 | 1496714 |
| antivenom and biological effects of ar-turmerone isolated from curcuma longa (zingiberaceae) | a potent antivenom against snakebite was isolated from curcuma longa, a plant commonly used in traditional brazilian medicine. the fraction consisting of ar-turmerone neutralized both the hemorrhagic activity present in bothrops jararaca venom, and the lethal effect of crotalus durissus terrificus venom in mice. immunological studies demonstrated that this fraction also inhibited the proliferation and the natural killer activity of human lymphocytes. | 1992 | 1440627 |
| curcumin as an inhibitor of cancer. | curcumin i (cur i) and curcumin iii (cur iii) are the yellow coloring phenolic compounds isolated from the spice turmeric. the effect of curcumins on different stages of development of cancer was studied. cur i inhibited benzopyrene- (bp) induced forestomach tumors in female swiss mice, and cur iii inhibited dimethylbenzanthracene- (dmba) induced skin tumors in swiss bald mice. cur i also inhibited dmba-initiated, tetradeconyl phorbol acetate-promoted skin tumors in female swiss mice. in vitro 3 ... | 1992 | 1578097 |
| reversal of aflatoxin induced liver damage by turmeric and curcumin. | the effect of certain food additives on aflatoxin production by aspergillus parasiticus has been studied in vitro. extracts of turmeric (curcuma longa), garlic (allium sativum) and asafoetida (ferula asafoetida) inhibited the aflatoxin production considerably (more than 90%) at concentrations of 5-10 mg/ml. similar results were also seen using butylated hydroxytoluene, butylated hydroxyanisole and ellagic acid at concentration 0.1 mm. curcumin, the antioxidant principle from curcuma longa did no ... | 1992 | 1394115 |
| homeostasis as regulated by activated macrophage. ii. lps of plant origin other than wheat flour and their concomitant bacteria. | in order to seek a macrophage-activating substance, lipopolysaccharide (lps) of plant origin other than that of wheat flour was surveyed. a large amount of lps (10-100 micrograms/g) was detected in laminaria japonica (kelp), curcuma longa (turmeric), undaria pinnatifida and other substances. since concomitant bacteria possibly existing in root of farm products can be considered to contribute to lps of plant origin, a count was taken of bacterial cells both dead and alive. this count revealed tha ... | 1992 | 1525958 |
| inhibitory effect of curcumin on fatty acid desaturation in mortierella alpina 1s-4 and rat liver microsomes. | an extract of rhizomes of curcuma longta l. (turmeric) inhibited the desaturation of dihomo-gamma-linolenic acid (dgla) in the arachidonic acid (aa) producing fungus mortierella alpina 1s-4. the factor responsible for this phenomenon was isolated and identified as curcumin (diferuloyl methane). mycelial dgla levels increased about two-fold (22.3 mg/g dry weight) with a concomitant decrease in aa levels when the fungus was cultivated with curcumin. the 50% inhibitory concentration against delta 5 ... | 1992 | 1453881 |
| the analysis of essential oils and extracts (oleoresins) from seasonings--a critical review. | a critical review of the analytical methods employed for the determination of the relevant components of seasonings is presented. where the available methods were inadequate, new ones have been devised. particular emphasis has been placed on those methods of analysis that provide a rapid and sufficiently accurate appraisal of seasoning extracts and essential oils from seasonings under routine control laboratory conditions. at the same time, the margin of error of these methods has been determine ... | 1977 | 336288 |
| inhibitory effect of curcumin, an anti-inflammatory agent, on vascular smooth muscle cell proliferation. | the effects of curcumin, an anti-inflammatory agent from curcuma longa, on the proliferation of blood mononuclear cells and vascular smooth muscle cells were studied. proliferative responses were determined from the uptake of tritiated thymidine. in human peripheral blood mononuclear cells, curcumin dose dependently inhibited the responses to phytohemagglutinin and mixed lymphocyte reaction at the dose ranges of 10(-6) to 3 x 10(-5) and 3 x 10(-6) to 3 x 10(-5) m, respectively. curcumin (10(-6) ... | 1992 | 1426014 |
| inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin. | topical application of curcumin, the major yellow pigment in turmeric and curry, has a potent inhibitory effect on 12-o-tetradecanoylphorbol-13-acetate (tpa)-induced tumor promotion in mouse skin. the structurally related compounds chlorogenic acid, caffeic acid and ferulic acid are less potent inhibitors. curcumin is a potent inhibitor of tpa-induced ornithine decarboxylase activity and inflammation in mouse skin whereas chlorogenic acid, caffeic acid and ferulic acid are only weakly active or ... | 1991 | 1908616 |
| inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. | topical application of curcumin, the yellow pigment in turmeric and curry, strongly inhibited 12-o-tetradecanoylphorbol-13-acetate (tpa)-induced ornithine decarboxylase activity, dna synthesis, and tumor promotion in mouse skin (huang et al., cancer res., 48: 5941-5946, 1988). chlorogenic acid, caffeic acid, and ferulic acid (structurally related dietary compounds) were considerably less active. in the present study, topical application of curcumin markedly inhibited tpa- and arachidonic acid-in ... | 1991 | 1899046 |
| mutagenic activity of south indian food items. | dietary components and food dishes commonly consumed in south india were screened for their mutagenic activity. kesari powder, calamus oil, palm drink, toddy and kewra essence were found to be strongly mutagenic; garlic, palm oil, arrack, onion and pyrolysed portions of bread toast, chicory powder were weakly mutagenic, while tamarind and turmeric were not. certain salted, sundried and oil fried food items were also mutagenic. cissus quadrangularis was mutagenic, while 'decoctions' of cumin seed ... | 1991 | 1769715 |
| treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. | the clinical efficacy of a herbomineral formulation containing roots of withania somnifera, the stem of boswellia serrata, rhizomes of curcuma longa and a zinc complex (articulin-f), was evaluated in a randomized, double-blind, placebo controlled, cross-over study in patients with osteoarthritis. after a one-month single blind run-in period, 42 patients with osteoarthritis were randomly allocated to receive either a drug treatment or a matching placebo for a period of three months. after a 15-da ... | 1991 | 1943180 |
| antimicrobial efficacy of the essential oil of curcuma longa. | | 1978 | 730260 |
| effect of a new fluorochrome on pre- and post-uv treatment of taphrina maculans butler. | taphrin maculans butler incites leaf spots disease in turmeric (curcuma longa l.) plants. the pathogen forms two types of colonies namely, salmon-red and and creamy-white in the artificial medium when isolated from a single infection spot. both strains resemble yeasts in morphology. the two strains were subjected to uv irradiation. the salmon-red one showed higher resistance to uv than the white one, presumably due to the presence of a red pigment in the former. when spores of the salmon-red str ... | 1977 | 610063 |
| dna damage by smoke: protection by turmeric and other inhibitors of ros. | twigs-dry leaves smoke condensate (tds), as a source of clastogenic ros and carcinogenic pah, was investigated for its in vitro dna-damaging effect in calf thymus dna and human peripheral lymphocytes. an aqueous turmeric component--aq.t--with an established antioxidant activity, was tested as a dna protectant. tds induced 13-fold damage to calf thymus dna as judged by the emergence of a dna damage specific, fluorescent product (em: 405 nm). aq.t at 800 ng/microl extended 69% protection to calf t ... | 1991 | 1937145 |
| insulin potentiating factor and chromium content of selected foods and spices. | an unidentified factor that potentiates the action of insulin in glucose metabolism was investigated in selected foods and spices. chromium content of these foods and spices was also determined. foods and spices were extracted with 0.1n nh4oh (1:20, w/v) and the supernatants assayed for insulin potentiation activity in the rat epididymal fat cell assay. among the selected foods, tuna fish, peanut butter, and vanilla ice cream had some insulin potentiating activity. among the spices, apple pie sp ... | 1990 | 1702671 |
| evaluation of turmeric (curcuma longa) for gastric and duodenal antiulcer activity in rats. | an ethanol extract of turmeric was studied in rats for its ability to inhibit gastric secretion and to protect gastroduodenal mucosa against the injuries caused by pyloric ligation, hypothermic-restraint stress, indomethacin, reserpine and cysteamine administration and cystodestructive agents including 80% ethanol, 0.6 m hcl, 0.2 m naoh and 25% nacl. an oral dose of 500 mg/kg of the extract produced significant anti-ulcerogenic activity in rats subjected to hypothermic-restraint stress, pyloruic ... | 1990 | 2345457 |
| cytotoxic and cytoprotective activities of curcumin. effects on paracetamol-induced cytotoxicity, lipid peroxidation and glutathione depletion in rat hepatocytes. | the cytoprotective effect of curcumin, a natural constituent of curcuma longa, on the cytotoxicity of paracetamol in rat hepatocytes was studied. paracetamol was selected as a model-toxin, since it is known to be bioactivated by 3-methylcholanthrene inducible cytochromes p450 presumably to n-acetyl-p-benzoquinone imine (napqi), a reactive metabolite which upon overdosage causes protein- and non-protein thiol-depletion, lipid peroxidation and cytotoxicity measured as ldh-leakage. at low concentra ... | 1990 | 2353930 |
| fuel smoke condensate induced dna damage in human lymphocytes and protection by turmeric (curcuma longa). | twigs-dry leaves smoke condensate (tds) was investigated for its dna damaging activity in human peripheral lymphocytes, by using a sensitive method, fluorescence analysis of dna unwinding (fadu). an aqueous turmeric component (aq.t) was studied as a protective agent. tds at one to 100 folds dilution induced 55% dna damage at 20 min, while 12-o-tetradecanoylphorbol-13-acetate (tpa) at 10 ng/ml induced only 25% damage. aq.t at 300 ng/microliter afforded 90% protection to dna against tds and 65% ag ... | 1990 | 2366750 |
| extracts from two frequently consumed spices--cumin (cuminum cyminum) and turmeric (curcuma longa)--inhibit platelet aggregation and alter eicosanoid biosynthesis in human blood platelets. | in the traditional indian system of medicine, ayurveda, several spices and herbs are claimed to possess medicinal properties, such as being antithrombotic, antiatherosclerotic, hypolipidemic, anti-inflammatory etc. earlier we have reported that extracts from several spices behave as antiaggregatory agents and inhibit eicosanoid synthesis. similar studies with extracts prepared from cumin (cuminum cyminum) and turmeric (curcuma longa) were undertaken. ethereal extract of both cumin and turmeric i ... | 1989 | 2503839 |
| photokilling of bacteria by the natural dye curcumin. | curcumin is a yellow-orange compound derived from the root of curcuma longa (zingiberaceae family), that has been used as a medicine, spice and coloring agent. curcumin has proved nontoxic in a number of cell culture and whole animal studies. curcumin has, however, been reported to have bactericidal effects at very high concentrations. when illuminated, curcumin exerted potent phototoxic effects in micromolar amounts. gram-negative bacteria displayed greater resistance to curcumin phototoxicity ... | 1989 | 2655550 |
| food colorants: anthocyanins. | interest in food colorants as shown by the number of patents has doubled in recent years with natural pigments outnumbering synthetics by five to one. the natural colorant area can be subdivided into anthocyanins, betalains, chlorophylls, carotenoids, flavonoids, polyphenols, monascus, hemes, quinones, biliproteins, safflower, turmeric, and miscellaneous. all involve different groups of chemical compounds which may be used directly as colorants, or may be chemically modified to produce different ... | 1989 | 2690857 |
| curcumins as inhibitors of nitrosation in vitro. | the effects of turmeric extract and its pure yellow pigments curcumin i, ii and iii were tested on the nitrosation of methylurea by sodium nitrite at ph 3.6 and 30 degrees c. the nitrosomethylurea formed was monitored by checking the mutagenicity in s. typhimurium strains ta1535 and ta100 without metabolic activation. turmeric extract as well as curcumins exhibit dose-dependent decreases of nitrosation. curcumin iii was the most effective nitrosation inhibitor among the compounds tested. the sim ... | 1988 | 3054526 |
| hypolipidaemic effects of curcuma longa l and nardostachys jatamansi, dc in triton-induced hyperlipidaemic rats. | fifty per cent ethanolic extract of curcuma longa (tuber) and nardostachys jatamansi (whole plant) feeding elevates hdl-cholesterol/total cholesterol ratio. the extracts also caused a significant reduction in the ratio of total cholesterol/phospholipids. curcuma longa exhibited better cholesterol and triglyceride lowering activity [ch = -85%; tg = -88%] as compared to n. jatamansi in triton-induced hyperlipidaemic rats. in view of the protective action of hdl against heart disease and atherogene ... | 1988 | 3215683 |
| protective role of aqueous turmeric extract against mutagenicity of direct-acting carcinogens as well as benzo [alpha] pyrene-induced genotoxicity and carcinogenicity. | turmeric (curcuma longa linn.) has been shown to inhibit chemical carcinogenesis. in this study, we compared the chemopreventive efficacy of an aqueous turmeric extract (aqte) and its constituents, curcumin-free aqueous turmeric extract (cfaqte) and curcumin, using the salmonella typhimurium mutagenicity assay and the bone marrow micronucleus test in female swiss mice. aqte exhibited antimutagenic activity against direct-acting mutagens, 4-nitro-o-phenylenediamine and 1-methyl-3-nitro-1-nitrosog ... | 1992 | 1618892 |
| organochlorine pesticide residues in different indian cereals, pulses, spices, vegetables, fruits, milk, butter, deshi ghee, and edible oils. | a total of 244 samples of cereals (wheat flour, rice, and maize), pulses (arhar, moong, gram, lentil, and black gram), spices (turmeric, chili, coriander, and black pepper), vegetables (potato, onion, spinach, cabbage, brinjal, and tomato), fruits (mango, guava, apple, and grape), milk, butter, deshi ghee, and edible oils (vegetable, mustard, groundnut, and sesame) collected from different cities of northern province (utter pradesh) were analyzed by gas liquid chromatography for the presence of ... | 1990 | 1698760 |
| plant products as protective agents against cancer. | out of various spices and leafy vegetables screened for their influence on the carcinogen-detoxifying enzyme, glutathione-s-transferase (gst) in swiss mice, cumin seeds, poppy seeds, asafoetida, turmeric, kandathipili, neem flowers, manathakkali leaves, drumstick leaves, basil leaves and ponnakanni leaves increased gst activity by more than 78% in the stomach, liver and oesophagus, - high enough to be considered as protective agents against carcinogenesis. glutathione levels were also significan ... | 1990 | 2283166 |
| evaluation of mutagenic activity of turmeric extract containing curcumin, before and after activation with mammalian cecal microbial extract of liver microsomal fraction, in the ames salmonella test. | | 1988 | 3285917 |
| nonmutagenicity of curcumin and its antimutagenic action versus chili and capsaicin. | turmeric, which is one of the commonly used spices in indian cooking, was tested for mutagenicity using the ames test. the alcoholic extract of fresh or dried turmeric, its principal components, and pyrolyzed turmeric powder and curcumin were tested for mutagenicity in salmonella typhimurium strains with and without metabolic activation. none of these were mutagenic in all the tester strains. chilies (which are used with turmeric powder) and their principal alkaloid capsaicin were mutagenic in t ... | 1986 | 3526291 |
| in vitro antimutagenicity of curcumin against environmental mutagens. | the effects of curcumin, the yellow pigment of the spice, turmeric (curcuma longa) on the mutagenicity of several environmental mutagens were investigated in the salmonella/microsome test with or without aroclor 1254-induced rat-liver homogenate (s-9 mix). with salmonella typhimurium strain ta98 in the presence of s-9 mix, curcumin inhibited the mutagenicity of bidi and cigarette smoke condensates, tobacco and masheri extracts, benzo[a]pyrne and dimethyl benzo[a]anthracene in a dose-dependent ma ... | 1987 | 3623345 |
| the influence of turmeric and curcumin on cholesterol concentration of eggs and tissues. | an experiment was conducted in order to study the hypocholesteremic effect of tumeric and its coloring principle namely curcumin both in the presence and absence of dietary cholesterol. laying hens were used as the experimental animals and they were fed the experimental diets for a duration of 8 weeks. the results of the experiment showed that tumeric or various levels of curcumin had no adverse effect on egg production, egg weight and feed to egg ratio. moreover tumeric or various levels of cur ... | 1976 | 945572 |
| comparison of anti-inflammatory activity of various extracts of curcuma longa (linn). | | 1976 | 965061 |
| curcuma longa (linn) drops in corneal wound healing. | in this study, an attempt has been made to evaluate the cortisone like inhibitory activity on healing of wounds of curcuma longa extracts-aqueous extract (2.8%) and alcoholic extract (1.125%) on the healing of superficial and penetrating corneal wounds in albino rabbits. it was observed that curcuma longa aqueous drops (a) definitely delayed healing of superficial corneal wounds (p less than 0.001), (b) delayed healing of penetrating corneal wounds also and markedly reduced the tensile strength ... | 1984 | 6535298 |
| antihepatotoxic principles of curcuma longa rhizomes. | | 1983 | 6657788 |
| lack of mutagenic effect of turmeric oleoresin and curcumin in the salmonella/mammalian microsome test. | | 1982 | 6759931 |
| toxicity studies on turmeric (curcuma longa): acute toxicity studies in rats, guineapigs & monkeys. | | 1980 | 6772551 |
| effect of 1-phenylpentanol on release of secretin and exocrine pancreatic secretion in dogs and humans. | 1-phenyl-1-hydroxy-n-pentane is a synthetic derivative of an ingredient of curcuma longa that is used as a condiment and dye. the effects of 1-phenyl-1- hydroxy-n-pentane on release of secretin, gastrin, and pancreatic secretion of bicarbonate and protein were studied in both dogs and humans. in fasting dogs with gastric fistulas and modified herrera's pancreatic fistulas, intraduodenal administration of 1-phenyl-1-hydroxy-n-pentane (ph 6.7) in three different doses (25, 50, and 100 mg/kg) resul ... | 1983 | 6840488 |
| genetic effects of turmeric and curcumin in mice and rats. | incorporation of either turmeric (0.5%) or curcumin (0.015%) into diets of mice did not show significant effect on the incidence of micronucleated polychromatic erythrocytes, structural and numerical aberrations in bone-marrow chromosomes, pregnancy rate, number of live and dead embryos, total implants and mutagenic index. also rats fed cooked diets containing turmeric (0.5 and 0.05%) did not show significant differences in the incidence of chromosomal aberrations in their bone marrow. | 1980 | 7432370 |
| chemoprevention of mammary tumor virus-induced and chemical carcinogen-induced rodent mammary tumors by natural plant products. | the natural plant products turmeric, beta-carotene, catechin, and betel leaf extract were evaluated for their antitumor effects on mammary tumorigenesis in murine mammary tumor expressing c3h (jax) mice and in wistar rats treated with the chemical carcinogen 7-12-dimethylbenz(a)anthracene (dmba). administration of turmeric through the diet and of beta-carotene, catechin, and betel leaf extract through the drinking water to virgin female c3h mice resulted in decreased tumor incidence and tumor bu ... | 1994 | 7526904 |
| effects of three dietary phytochemicals from tea, rosemary and turmeric on inflammation-induced nitrite production. | in chronic inflammation, cytokines induce the production of nitric oxide (no.) that is converted to dna damaging and carcinogenic peroxynitrite and nitrite. the compounds epigallocatechin gallate (egcg), carnosol, and curcumin are non-vitamin phytochemicals contained in commonly consumed dietary plants. they are known to be anti-inflammatory and cancer preventive. therefore, we studied their effect on the generation of peroxynitrite radicals and nitrite. they inhibited lipopolysaccharide (lps) a ... | 1995 | 7553604 |
| effects of curcumin on the formation of benzo[a]pyrene derived dna adducts in vitro. | the effects of turmeric (t), curcumins (cs), aqueous turmeric extract (ate) and curcumin-free aqueous turmeric extract (cfate) on the formation of [3h]benzo[a]pyrene ([3h]b(a)p)-derived dna adducts was studied in vitro employing mouse liver s9. a dose-dependent decrease in binding of [3h]b(a)p metabolites to calf thymus dna was observed in the presence of t, cs and ate but not in the presence of cfate, suggesting curcumins to be active principles. further studies employing mouse liver microsomes ... | 1995 | 7553610 |
| postnatal modulation of hepatic biotransformation system enzymes via translactational exposure of f1 mouse pups to turmeric and curcumin. | the potential for the transfer of active principle(s) of turmeric (curcuma longa l.) and curcumin (major pigment in turmeric) via translactational route and its modulatory influence on the hepatic biotransformation system enzymes in the lactating dams and their suckling offspring was assessed. turmeric (4 g/kg b.w. per day) and curcumin (0.4 g/kg b.w. per day) induced significant (p < 0.01) increase in the hepatic levels of glutathione s-transferase (gst) and acid soluble sulfhydryl (-sh) after ... | 1995 | 7553612 |
| anti-inflammatory studies on curcuma longa (turmeric). | | 1971 | 5132235 |
| curcumin, a major component of food spice turmeric (curcuma longa) inhibits aggregation and alters eicosanoid metabolism in human blood platelets. | in traditional medicine, ayurveda, several spices and herbs are held to possess medicinal properties. earlier we have reported that extracts from several spices, including turmeric, inhibit platelet aggregation and modulate eicosanoid biosynthesis. due to their eicosanoid-modulating property, it was suggested that the spices may serve to provide clues to drugs directed to arachidonic acid (aa) pathway enzymes as pharmacological targets. curcumin, a major component of turmeric, inhibited platelet ... | 1995 | 7784468 |
| [effect of an alcohol extract and of active ingredients from curcuma longa on bacteria and fungi (author's transl)]. | | 1974 | 4848567 |
| anti-inflammatory and anti-arthritic activity of volatile oil of curcuma longa (haldi). | | 1972 | 5029117 |
| inhibition of human immunodeficiency virus type-1 integrase by curcumin. | curcumin (diferuloylmethane) is the yellow pigment in turmeric (curcuma longa l.) that is widely used as a spice, food coloring (curry) and preservative. curcumin exhibits a variety of pharmacological effects including antitumor, anti-inflammatory, and anti-infectious activities and is currently in clinical trials for aids patients. the effects of curcumin have been determined on purified human immunodeficiency virus type 1 (hiv-1) integrase. curcumin has an inhibitory concentration50 (ic50) for ... | 1995 | 7748198 |
| inhibition of tumor necrosis factor by curcumin, a phytochemical. | curcumin, contained in the rhizome of the plant curcuma longa linn, is a naturally occurring phytochemical that has been used widely in india and indonesia for the treatment of inflammation. the pleiotropic cytokine tumor necrosis factor-alpha (tnf) induces the production of interleukin-1 beta (il-1), and, together, they play significant roles in many acute and chronic inflammatory diseases. they have been implicated in the pathogenesis of intracellular parasitic infections, atherosclerosis, aid ... | 1995 | 7786295 |
| natural antioxidants. iii. antioxidative components isolated from rhizome of curcuma longa l. | | 1985 | 4042250 |
| chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. | human epidemiological and laboratory animal model studies have suggested that nonsteroidal antiinflammatory drugs reduce the risk of development of colon cancer and that the inhibition of colon carcinogenesis is mediated through the alteration in cyclooxygenase metabolism of arachidonic acid. curcumin, which is a naturally occurring compound, is present in turmeric, possesses both antiinflammatory and antioxidant properties, and has been tested for its chemopreventive properties in skin and fore ... | 1995 | 7812955 |
| effect of retinol deficiency and curcumin or turmeric feeding on brain na(+)-k+ adenosine triphosphatase activity. | the effect of retinol deficiency and curcumin and turmeric feeding on brain microsomal na(+)-k(+)atpase activity was investigated. the brain na(+)-k(+)atpase activity registered an increase of 148.5% as compared to the control group. upon treating retinol deficient rats with curcumin or turmeric, the abnormally elevated activity showed a decrease of 36.9 and 47.1%, respectively, when compared to the retinol deficient group. an increase in vmax by 67% and km by 66% for atp was observed in the ret ... | 1994 | 7845384 |
| curcumin inhibits tpa induced expression of c-fos, c-jun and c-myc proto-oncogenes messenger rnas in mouse skin. | curcumin is a major chemical constituent of turmeric normally eaten by humans. 12-o-tetradecanoyl phorbol-13-acetate (tpa) is a strong promoter of chemically induced skin cancer. the exact mechanism by which tpa promotes skin cancer is not clear. however, it is known that tpa elevates the expression of oncogenes involved in cell proliferation. recently, it has been shown that turmeric or curcumin significantly inhibits tpa-induced tumor promotion on mouse skin. however, the mechanism by which cu ... | 1994 | 7954373 |
| inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice. | curcumin (diferuloylmethane), a yellow pigment that is obtained from the rhizomes of curcuma longa linn., is a major component of turmeric and is commonly used as a spice and food-coloring agent. the inhibitory effects of feeding commercial grade curcumin (77% curcumin, 17% demethoxycurcumin, and 3% bisdemethoxycurcumin) in ain 76a diet on carcinogen-induced tumorigenesis in the forestomach, duodenum, and colon of mice were evaluated. administration p.o. of commercial grade curcumin in the diet ... | 1994 | 7954412 |
| influence of spices on protein utilisation of winged bean (psophocarpus tetragonolobus) and horsegram (dolichos biflorus). | the influence of a mixture of eleven spices commonly consumed in india on the utilisation of protein from boiled winged bean (psophocarpus tetragonolobus) and horsegram (dolichos biflorus) was studied at 10 and 20 percent level of protein intake in experimental rats. spices used in the mixture include red chillies (capsicum annum), black pepper (piper nigrum), coriander (coriandrum sativum), cumin (cuminum cyminum), garlic (allium sativum), ajowan (carum copticum), turmeric (curcuma longa), cara ... | 1994 | 7855088 |
| photocytotoxicity of curcumin. | curcumin, bis(4-hydroxy-3-methoxyphenyl)-1,6-diene-3,5-dione, is a yellow-orange dye derived from the rhizome of the plant curcuma longa. curcumin has demonstrated phototoxicity to several species of bacteria under aerobic conditions (dahl, t. a., et al., 1989, arch. microbiol. 151 183), denoting photodynamic inactivation. we have now found that curcumin is also phototoxic to mammalian cells, using a rat basophilic leukemia cell model, and that this phototoxicity again requires the presence of o ... | 1994 | 8016207 |
| subchronic oral toxicity of turmeric oleoresin in pigs. | turmeric oleoresin was fed for 102-109 days to groups of eight pigs (males and females) at dietary levels providing intakes of 60, 296 and 1551 mg/kg body weight/day. twelve pigs served as controls. the highest dose group showed a reduction in weight gain and in food-conversion efficiency. statistically significant dose-related increases in the weight of the liver and the thyroid were recorded at all dose levels. pericholangitis, hyperplasia of the thyroid and epithelial changes in the kidney an ... | 1985 | 4076930 |
| effect of curcuma longa (rhizomes) on fertility in experimental animals. | | 1974 | 4427957 |
| role of capsaicin, curcumin and dietary n-3 fatty acids in lowering the generation of reactive oxygen species in rat peritoneal macrophages. | reactive oxygen species (ros) generated by activated macrophages play an important role in the initiation of inflammation. ten different spice principles, some of which with known anti-inflammatory properties, were tested for their effect on generation of superoxide anions, hydrogen peroxide and nitrite radical generation by activated rat peritoneal macrophages. preincubation of macrophages with 10 microm capsaicin (from red pepper) or 10 microm curcumin (from turmeric) completely inhibited the ... | 1994 | 7981240 |
| in vitro studies on chemoprotective effect of purnark against benzo(a)pyrene-induced chromosomal damage in human lymphocytes. | human lymphocytes were used as an assay system to test chemopreventive activity of natural products. purnark, a mixture of extracts of turmeric, betel leaf and catechu, was tested for its chemoprotective activity against bp induced dna damage. sister chromatid exchange and micronuclei were used as markers to assess the protective activity of purnark. purnark gave 50-60% protection against bp induced sces and micronuclei. purnark at 100 micrograms dose did not show any genotoxicity. | 1994 | 8186767 |
| the anti-oxidant activity of turmeric (curcuma longa). | the turmeric anti-oxidant protein (tap) had been isolated from the aqueous extract of turmeric. the anti-oxidant principle was found to be a heat stable protein. trypsin treatment abolished the anti-oxidant activity. the anti-oxidant principle had an absorbance maximum at 280 nm. after gel filtration, the protein showed a 2-fold increase in anti-oxidant activity and showed 2 bands in the sds-page with approximate molecular weight range of 24,000 da. the protein showed a concentration-dependent i ... | 1995 | 7500637 |
| identification of an active principle in essential oils and hexane-soluble fractions of curcuma xanthorrhiza roxb. showing triglyceride-lowering action in rats. | curcuma xanthorrhiza roxb. (c. xanthorrhiza), known as temu lawak or javanese turmeric, has been traditionally used in indonesia for food and medicinal purposes. as little attention has been focused on the role of c. xanthorrhiza in lipid metabolism, the hypotriglyceridaemic activity and the active principles of the essential oil and hexane-soluble fractions prepared from c. xanthorrhiza were investigated in rats. the major component (approx. 65%) of the essential oil was identified as alpha-cur ... | 1994 | 8157222 |
| effect of turmeric on xenobiotic metabolising enzymes. | diet contains several substances capable of inhibiting chemical carcinogenesis. it is known that such inhibitors may either act directly by scavenging the reactive substances or indirectly by promoting mechanisms which enhance detoxification. turmeric which contains curcumin both in vitro and in vivo is an active antimutagen. studies were therefore conducted to evaluate the effects of turmeric on xenobiotic metabolising enzymes in hepatic tissue of rats fed turmeric ranging from 0.5-10% in the d ... | 1993 | 8332589 |
| effect of dietary turmeric (curcuma longa) on iron-induced lipid peroxidation in the rat liver. | male wistar rats were fed a control diet or the control diet supplemented with 1% (by weight) turmeric for 10 wk. in rats injected with 30 mg fe2+/kg body weight, lipid peroxidation was 29 and 35% lower in liver homogenates and microsomes, respectively, of turmeric-fed rats than in those of rats fed the control diet. the activities of superoxide dismutase, catalase and glutathione peroxidase were higher (by 19, 19 and 20%, respectively) in liver homogenates of rats fed the turmeric-containing di ... | 1994 | 8157223 |
| mechanism of antiinflammatory actions of curcumine and boswellic acids. | curcumine from curcuma longa and the gum resin of boswellia serrata, which were demonstrated to act as anti-inflammatories in in vivo animal models, were studied in a set of in vitro experiments in order to elucidate the mechanism of their beneficial effects. curcumine inhibited the 5-lipoxygenase activity in rat peritoneal neutrophils as well as the 12-lipoxygenase and the cyclooxygenase activities in human platelets. in a cell free peroxidation system curcumine exerted strong antioxidative act ... | 1993 | 8510458 |
| mutagenicity and anti-mutagenicity of selected spices. | using salmonella typhimurium strains ta 100 and ta 1535, the mutagenicity and anti-mutagenicity of extracts of several spices were checked. spices like pepper, pippali, ginger and mustard increased the number of revertants indicating their mutagenic potential. garlic extract on the other hand was found to inhibit the mutagenicity produced by direct acting mutagens such as n-methyl n'-nitro-n-nitrosoguanidine and sodium azide. asafoetida and turmetic extract were found to inhibit microsomal activ ... | 1995 | 8582746 |
| knowledge, attitude and beliefs about malaria in a tribal area of bastar district (madhya pradesh). | a sample survey of k.a.p. about malaria was carried out among sample of 359 inhabitants selected by random sampling in a tribal area of baster district, which is a hyper-endemic area of the disease, predominantly by p.falciparum infection and understanding about the problem of malaria was poor, only about 50% (ranging from 30% to 60%) of the respondents were aware about cause and signs and symptoms of malaria, breeding & resting habit of mosquito, usefulness of insecticidal spray and ill effect ... | 1993 | 8077001 |
| effect of intraduodenal infusion of tocamphyl on pancreatic exocrine secretion and gastrointestinal hormone release in rats. | tocamphyl is a synthetic choleretic that is derived from a root extract of curcuma longa, l. we investigated the effect of tocamphyl on pancreatic exocrine secretion and bile flow, and on the release of some gastrointestinal hormones, by administering it intraduodenally using anesthetized rats. tocamphyl stimulated pancreatic exocrine secretion in terms of volume and amylase output in a dose-related manner. neither a cck-receptor antagonist, cr1505 (loxiglumide), nor atropine sulfate infused int ... | 1994 | 7930779 |
| inhibitory effect of spices on in vitro histamine production and histidine decarboxylase activity of morganella morganii and on the biogenic amine formation in mackerel stored at 30 degrees c. | the inhibitory effects of clove, cinnamon, cardamom, turmeric and pepper on the histamine production and histidine decarboxylase activity of morganella morganii (a potent histamine-producing bacteria in fish) was examined at 30 degrees c using hplc. cinnamon and clove exhibited a significant (p < 0.01) inhibitory effect, whereas turmeric and cardamom had a moderate effect. these spices were applied to whole mackerel at a level of 3% and their inhibitory effect on biogenic amine formation at 30 d ... | 1996 | 8765991 |
| effect of turmeric and curcumin on bp-dna adducts. | many human cancers that are widely prevalent today can be prevented through modifications in life-styles, of which diet appears to be an important agent. several dietary constituents modulate the process of carcinogenesis and prevent genotoxicity. many plant constituents including turmeric appear to be potent antimutagens and antioxidants. therefore the modulatory effects of turmeric and curcumin on the levels of benzo[a]pyrene induced dna adducts in the livers of rats were studied by the newly ... | 1993 | 8453726 |
| enhancing effect of ultraviolet a on ornithine decarboxylase induction and dermatitis evoked by 12-o-tetradecanoylphorbol-13-acetate and its inhibition by curcumin in mouse skin. | previous studies have demonstrated appreciable tumor induction in mouse skin by daily irradiation with high-power long-wavelength ultraviolet a (uva). | 1996 | 8993955 |
| inhibition of 7,12-dimethylbenz[a]anthracene (dmba)-induced mammary tumorigenesis and dmba-dna adduct formation by curcumin. | curcumin, a constituent of the traditional indian spice and medicine turmeric, was evaluated for its capacity to inhibit the mammary tumor initiating activity of 7,12-dimethylbenz[a]anthracene (dmba) and the in vivo formation of mammary dmba-dna adducts in the female rat. administration (i.p.) of curcumin at 100 mg/kg and 200 mg/kg doses was associated with a significant decrease in the number of palpable mammary tumors and mammary adenocarcinomas. the in vivo formation of mammary dmba-dna adduc ... | 1996 | 8635149 |
| nematocidal activity of turmeric: synergistic action of curcuminoids. | a new curcuminoid, cyclocurcumin (iv), was isolated from the nematocidally active fraction of turmeric, the rhizome of curcuma longa, together with three known curcuminoids, curcumin (i), demethoxycurcumin (ii) and bisdemethoxycurcumin (iii). the structure of iv was elucidated on the basis of spectral data and confirmed by the partial synthesis from curcumin (i). although the above curcuminoids were ineffective when they were applied independently, the nematocidal activity increased remarkably w ... | 1993 | 8221978 |
| hypolipidemic action of curcumin, the active principle of turmeric (curcuma longa) in streptozotocin induced diabetic rats. | streptozotocin-induced diabetic rats were maintained on 0.5% curcumin containing diet for 8 weeks. blood cholesterol was lowered significantly by dietary curcumin in these diabetic animals. cholesterol decrease was exclusively from ldl-vldl fraction. significant decrease in blood triglyceride and phospholipids was also brought about by dietary curcumin in diabetic rats. in a parallel study, wherein diabetic animals were maintained on a high cholesterol diet, the extents of hypercholesterolemia a ... | 1997 | 9046034 |
| effect of plant extracts and systemic fungicide on the pineapple fruit-rotting fungus, ceratocystis paradoxa. | antifungal activities of extracts of sixteen plants were tested against ceratocystis paradoxa which causes soft rot of pineapples. xanthium strumarium was the most effective followed by allium sativum. the effectiveness of various extracts against c. paradoxa was in the decreasing order of meriandra bengalensis, mentha piperita, curcuma longa, phlogacanthus thyrsiflorus, toona ciliata, vitex negundo, azadirachta indica, eupatorium birmanicum, ocimum sanctum and leucas aspera. extracts of cassia ... | 1996 | 9022263 |
| inhibition of the hiv-1 and hiv-2 proteases by curcumin and curcumin boron complexes. | curcumin, a relatively non-toxic natural product isolated from curcuma longa, is a modest inhibitor of the hiv-1 (ic50 = 100 microm) and hiv-2 (ic50 = 250 microm) proteases. simple modifications of the curcumin structure raise the ic50 value but complexes of the central dihydroxy groups of curcumin with boron lower the ic50 to a value as low as 6 microm. the boron complexes are also time-dependent inactivators of the hiv proteases. the increased affinity of the boron complexes may reflect bindin ... | 1993 | 8087563 |
| antimutagenic and anticarcinogenic activity of natural and synthetic curcuminoids. | five synthetic curcuminoids and three natural curcuminoids were investigated for their antimutagenic and anti-promotional activity. the natural curcuminoids, curcumin i (diferuloylmethane), curcumin ii (feruloyl-p-hydroxycinnamoylmethane) and curcumin iii (bis-(p-hydroxycinnamoyl)methane) isolated from curcuma longa were found to be potent inhibitors of mutagenesis and crotean oil-induced tumour promotion. curcumin iii produced 87.6% inhibition to 2-acetamidofluorene (2-aaf) induced mutagenesis, ... | 1996 | 8879271 |
| spice allergy evaluated by results of patch tests. | allergic contact dermatitis caused by spices is well documented; however, commercial patch tests are unavailable. between october, 1991, and august, 1992, a series of fifty-five patients with suspected contact dermatitis were tested at ochsner clinic for sensitivity to a group of spices at concentrations of 10 percent and 25 percent in petrolatum. concordant patch test results (positive at concentrations of 10 percent and 25 percent) were most common with ginger (seven), nutmeg(five), and oregan ... | 1993 | 8299390 |
| protective effect of food additives on aflatoxin-induced mutagenicity and hepatocarcinogenicity. | food additives such as turmeric (curcuma longa), and active ingredient curcumin (diferuloyl methane), asafoetida (flavouring agent), butylated hydroxyanisole (bha), butylated hydroxytoluene (bht) and ellagic acid were found to inhibit the mutagenesis induced by aflatoxin b1 (afb1) (0.5 microg/plate) in salmonella tester strains ta 98 and ta 100. turmeric and curcumin, which were the most active, inhibited mutation frequency by more than 80% at concentrations of 2 microg/plate. other food additiv ... | 1997 | 9149115 |
| inhibitory effect of dietary curcumin on skin carcinogenesis in mice. | laboratory animal model studies have suggested that curcumin may play an important role in inhibiting the process of carcinogenesis. curcumin, the yellow pigment that is obtained from rhizomes of the plant curcuma longa linn (family zingiberaceae), is commonly used as a spice and food coloring agent. the present study was designed to investigate the chemopreventive action of dietary curcumin on 7,12-dimethylbenz[a]anthracene (dmba)-initiated and 12-o-tetradecanoylphorbol-13-acetate (tpa)-promote ... | 1997 | 9215864 |
| inhibitory effects of topical application of low doses of curcumin on 12-o-tetradecanoylphorbol-13-acetate-induced tumor promotion and oxidized dna bases in mouse epidermis. | the effects of topical applications of very low doses of curcumin (the major yellow pigment in turmeric and the indian food curry) on 12-o-tetradecanoylphorbol-13-acetate (tpa)-induced oxidation of dna bases in the epidermis and on tumor promotion in mouse skin were investigated. cd-1 mice were treated topically with 200 nmol of 7,12-dimethylbenz[a]anthracene followed one week later by 5 nmol of tpa alone or together with 1, 10, 100 or 3000 nmol of curcumin twice a week for 20 weeks. curcumin-me ... | 1997 | 9054592 |
| inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon. | the present study was designed to investigate the modulatory role of dietary curcumin on (i) azoxymethane (aom)-induced ornithine decarboxylase (odc), tyrosine protein kinase (tpk) and arachidonic acid metabolism in liver and colonic mucosa of male f344 rats, (ii) in vitro arachidonic acid metabolism in the liver and colonic mucosa and (iii) aom-induced aberrant crypt foci (acf) formation in the colon of f344 rats. at 5 weeks of age groups of animals were fed one of the experimental diets contai ... | 1993 | 8242846 |
| antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines. | pharmacologically safe compounds that can inhibit the proliferation of tumor cells have potential as anticancer agents. curcumin, a diferuloylmethane, is a major active component of the food flavor turmeric (curcuma longa) that exhibits anticarcinogenic properties in vivo. in vitro, it suppressed c-jun/ap-1 and nf-kappab activation and type 1 human immunodeficiency virus long-terminal repeat-directed gene expression. we examined the antiproliferative effects of curcumin against several breast tu ... | 1997 | 9215611 |
| effect of curcumin and eugenol on iron-induced hepatic toxicity in rats. | male wistar rats injected i.p. with 30 mg fe2+/kg body weight show hepatic damage as measured by an increase in lipid peroxides which correlated with elevated serum enzymes, alanine aminotransferase (alat), aspartate aminotransferase (asat) and lactate dehydrogenase (ldh). oral administration of spice principles, curcumin from turmeric (30 mg/kg body weight) or eugenol from cloves (100 mg/kg body weight), for 10 days lowered the liver and serum lipid peroxide levels, serum alat, asat and ldh, en ... | 1996 | 8597030 |
| protective effect of curcuminoids on epidermal skin cells under free oxygen radical stress. | curcuminoids from curcuma longa l. (zingiberaceae) protected normal human keratinocytes from hypoxanthine/ xanthine oxidase injury. since curcuminoids synergistically inhibited nitroblue tetrazolium reduction, a decrease in superoxide radical formation leading to lower levels of cytotoxic hydrogen peroxide was proposed as an explanation for this protective effect. | 1997 | 9225611 |
| inhibition of cyclic amp-dependent protein kinase by curcumin. | curcumin [diferuloylmethane; 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione], a major bioactive secondary metabolite found in the rhizomes of turmeric (curcuma longa), is an inhibitor of ca(2+)- and phospholipid-dependent protein kinase c (pkc) and of the catalytic subunit (cak) of cyclic amp-dependent protein kinase (ic50 values 15 and 4.8 microm, respectively). curcumin inhibits plant ca(2+)-dependent protein kinase (cdpk) (ic50 41 microm), but does not inhibit myosin light chain ... | 1996 | 8768315 |
| antifungal activity of turmeric oil extracted from curcuma longa (zingiberaceae). | turmeric oil and curcumin, isolated from curcuma longa l., were studied against fifteen isolates of dermatophytes, four isolates of pathogenic molds and six isolates of yeasts. the inhibitory activity of turmeric oil was tested in trichophyton-induced dermatophytosis in guinea pigs. the results showed that all 15 isolates of dermatophytes could be inhibited by turmeric oil at dilutions of 1:40-1:320. none of the isolates of dermatophytes were inhibited by curcumin. the other four isolates of pat ... | 1995 | 8824742 |
| curcumin, a natural plant phenolic food additive, inhibits cell proliferation and induces cell cycle changes in colon adenocarcinoma cell lines by a prostaglandin-independent pathway. | curcumin, the active ingredient of the rhizome of the plant turmeric (curcuma longa linn), a commonly used spice, prevents cancer in animal tumor models. its mechanism of action is unknown; curcumin may act by inhibiting arachidonic acid metabolism. to explore the mechanism of curcumin's chemopreventive effect, we studied its role in proliferation and apoptosis in the ht-29 and hct-15 human colon cancer cell lines. curcumin dose-dependently reduced the proliferation rate of both cell lines, caus ... | 1997 | 9422331 |
| influence of retinol deficiency and curcumin/turmeric feeding on tissue microsomal membrane lipid peroxidation and fatty acids in rats. | the effect of retinol deficiency and curcumin/turmeric on lipid peroxidation and fatty acid profile was studied in liver, kidney, spleen and brain microsomes of rats. results revealed an increase in lipid peroxidation in retinol deficient liver by 32%, kidney 30%, spleen 24% and brain 43% compared to the controls. feeding 0.1% curcumin or turmeric for three weeks in diet to retinol deficient rats reduced the lipid peroxidation respectively to 12.5 or 22.6%, in liver, 23.7 or 24.1% in kidney, 14. ... | 1997 | 9350032 |
| inhibitory effect of curcuminoids on mcf-7 cell proliferation and structure-activity relationships. | curcumin, demethoxycurcumin and bisdemethoxycurcumin are the yellow coloring phenolic compounds isolated from the spice turmeric. this study was part of a program correlating the biological activity and molecular structure of antitumor agents; the effect of these curcuminoids and cyclocurcumin (cyclocur) was examined on the proliferation of mcf-7 human breast tumor cells. curcuminoids appeared to be potent inhibitors, whereas cyclocur was less inhibitory. to contribute to our understanding of th ... | 1998 | 9714342 |
| antioxidative activity of tetrahydrocurcuminoids. | in order to develop a new type of antioxidative compound which has both the phenolic and beta-diketone moiety in the same molecule, we converted three known curcuminoids, curcumin (diferuloylmethane, u1), (4-hydroxy-3-methoxycinnamoyl)methane (u2), and bis-(4-hydroxycinnamoyl)methane (u3), which are the natural antioxidants of curcuma longa l. (tumeric), to tetrahydrocurcuminoids (thu1, thu2, and thu3, respectively) by hydrogenation, and evaluated their antioxidative activity by using linoleic a ... | 1995 | 8520105 |
| curcumin protects against 4-hydroxy-2-trans-nonenal-induced cataract formation in rat lenses. | age-related cataractogenesis is a significant health problem worldwide. oxidative stress has been suggested to be a common underlying mechanism of cataractogenesis, and augmentation of the antioxidant defenses of the ocular lens has been shown to prevent or delay cataractogenesis. the present studies were designed to test the efficacy of curcumin, an antioxidant present in the commonly used spice turmeric, in preventing cataractogenesis in an in vitro rat model. rats were maintained on an ain-76 ... | 1996 | 8901798 |
| adjuvant chemoprevention of experimental cancer: catechin and dietary turmeric in forestomach and oral cancer models. | catechin and dietary turmeric (curcuma longa) were used as chemopreventive agents in benzo[a]pyrene induced forestomach tumors in swiss mice and methyl-(acetoxymethyl)-nitrosamine induced oral mucosal tumors in syrian golden hamsters. catechin in drinking water and dietary turmeric significantly inhibited the tumor burden and tumor incidence in both tumor models. the induction of oral tumors in golden hamsters was delayed by catechin and dietary turmeric. adjuvant chemoprevention utilising both ... | 1994 | 7898128 |