Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| curcumin and kolaviron ameliorate di-n-butylphthalate-induced testicular damage in rats. | the present study was carried out to evaluate the ameliorative effects of kolaviron (a biflavonoid from the seeds of garcinia kola) and curcumin (from the rhizome, curcuma longa l.) on the di-n-butylphthalate (dbp)-induced testicular damage in rats. administration of dbp to rats at a dose of 2 g/kg for 9 days significantly decreased the relative testicular weights compared to the controls, while the weights of other organs remained unaffected. curcumin or kolaviron did not affect all the organ w ... | 2007 | 17214610 |
| curcumin induces g2/m arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating akt and p38 mapk. | curcumin, a major active component of turmeric, is known to induce apoptosis in several types of cancer cells, but little is known about its activity in chemoresistant cells. hence, the aim of the present study was to investigate the anticancer properties of curcumin in cisplatin-resistant human ovarian cancer cells in vitro. the results indicated that curcumin inhibited the proliferation of both cisplatin-resistant (cr) and sensitive (cs) human ovarian cancer cells almost equally. enhanced supe ... | 2007 | 17218783 |
| changes in glycoprotein components in streptozotocin--nicotinamide induced type 2 diabetes: influence of tetrahydrocurcumin from curcuma longa. | curcuma longa (zingiberaceae) has been used traditionally as antidiabetic, and has been proven scientifically to possess high antioxidant activity and anticancer properties. the active components of curcuma longa such as curcumin and tetrahydrocurcumin (thc), a major colourless metabolite of curcumin also possesses antidiabetic, antiinflammatory and antioxidant activity. the ethnopharmacological value of this plant, the effect of thc on glycoproteins was carried out in normal and streptozotocin- ... | 2007 | 17226069 |
| dysregulation of the ubiquitin-proteasome system by curcumin suppresses coxsackievirus b3 replication. | curcumin (diferuloylmethane), a natural polyphenolic compound extracted from the spice turmeric, has been reported to have anti-inflammatory, antioxidant, and antiproliferative properties by modulating multiple cellular machineries. it inhibits several intracellular signaling pathways, including the mitogen-activated protein kinases (mapks), casein kinase ii (ckii), and the cop9 signalosome (csn), in various cell types. it has also been recently demonstrated that exposure to curcumin leads to th ... | 2007 | 17229707 |
| characterization and identification of diarylheptanoids in ginger (zingiber officinale rosc.) using high-performance liquid chromatography/electrospray ionization mass spectrometry. | in our continuing investigation of diarylheptanoids in zingiberaceae plants using liquid chromatography/electrospray ionization mass spectrometry (lc/esi-ms/ms), 26 diarylheptanoids were identified from fresh ginger rhizome. of the 26 compounds, 15 diarylheptanoids appear to be new compounds. in addition, the majority of these compounds (18) were acetylated, which is different from our investigation of diarylheptanoids from turmeric, another member of the zingiberaceae, which did not possess any ... | 2007 | 17238228 |
| immune response modulation by curcumin in a latex allergy model. | there has been a worldwide increase in allergy and asthma over the last few decades, particularly in industrially developed nations. this resulted in a renewed interest to understand the pathogenesis of allergy in recent years. the progress made in the pathogenesis of allergic disease has led to the exploration of novel alternative therapies, which include herbal medicines as well. curcumin, present in turmeric, a frequently used spice in asia has been shown to have anti-allergic and inflammator ... | 2007 | 17254346 |
| possible inhibitory mechanism of curcuma drugs on cyp3a4 in 1alpha,25 dihydroxyvitamin d3 treated caco-2 cells. | curcuma longa and c. zedoaria, belonging to genus curcuma, have become prevalent as supplements in east asia. curcumin is the most well-studied bioactive component isolated from rhizomes of c. longa and other curcuma species except c. zedoaria. in this study, we investigated the affects of c. longa, c. zedoaria from japan and curcumin on cyp3a4. caco-2 cells, in which cyp3a4 expression was induced by 1alpha,25-(oh)(2)-d(3), were used to mimic the metabolism of small intestine. caco-2 cells were ... | 2007 | 17270371 |
| redox regulation of cellular stress response in neurodegenerative disorders. | there is increasing evidence that reactive oxygen species (ros) are not only toxic but play an important role in cellular signaling and in the regulation of gene expression. a number of biochemical and physiologic stimuli, such as perturbation in redox status, expression of misfolded proteins, altered glyc(osyl)ation and glucose deprivation, overloading of products of polyunsaturated fatty acid peroxidation (hydroxynonenals, hne) or cholesterol oxidation and decomposition, can disrupt redox home ... | 2006 | 17274531 |
| curcumin, a curcuma longa constituent, acts on mapk p38 pathway modulating cox-2 and inos expression in chronic experimental colitis. | ulcerative colitis (uc) is a nonspecific inflammatory disorder characterized by oxidative and nitrosative stress, leucocyte infiltration and up-regulation of pro-inflammatory cytokines. mitogen-activated protein kinases (mapks), such as the p38 and the c-jun n-terminal kinase (jnk) modulate the transcription of many genes involved in the inflammatory process. curcumin is a polyphenol derived from curcuma longa, which is known to have anti-inflammatory activity. the aim of this study was to study ... | 2007 | 17276891 |
| bax and bak genes are essential for maximum apoptotic response by curcumin, a polyphenolic compound and cancer chemopreventive agent derived from turmeric, curcuma longa. | curcumin, an active ingredient of turmeric (curcuma longa), inhibits proliferation and induces apoptosis in cancer cells, but the sequence of events leading to cell death is poorly defined. the objective of this study was to examine the molecular mechanisms by which multidomain pro-apoptotic bcl-2 family members bax and bak regulate curcumin-induced apoptosis using mouse embryonic fibroblasts (mefs) deficient in bax, bak or both genes. curcumin treatment resulted an increase in the protein level ... | 2007 | 17277231 |
| nmr study of the solution structure of curcumin. | curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] is derived from the rhizomes of curcuma longa. although early studies concluded that curcumin exists predominantly as a keto-enol tautomer, 1b, in several recent articles the solution structure of curcumin has been represented as a beta-diketone tautomer, 1a. we have investigated the structure of curcumin in solvents ranging in polarity from cdcl3 to mixtures of dmso-d6 in water, and in buffered aqueous dmso-d6 solutions with ... | 2007 | 17315954 |
| ethnoveterinary medicines used for ruminants in british columbia, canada. | the use of medicinal plants is an option for livestock farmers who are not allowed to use allopathic drugs under certified organic programs or cannot afford to use allopathic drugs for minor health problems of livestock. | 2007 | 17324258 |
| curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage. | downhill running is associated with fiber damage, inflammation, delayed-onset muscle soreness, and various functional deficits. curcumin, a constituent of the indian spice turmeric has been investigated for its anti-inflammatory activity and may offset some of the damage and functional deficits associated with downhill running. this study examined the effects of curcumin on inflammation and recovery of running performance following downhill running in mice. male mice were assigned to downhill pl ... | 2007 | 17332159 |
| involvement of bcl-2 family members, phosphatidylinositol 3'-kinase/akt and mitochondrial p53 in curcumin (diferulolylmethane)-induced apoptosis in prostate cancer. | curcumin (diferulolylmethane), an active ingredient derived from the rhizome of the plant curcuma longa, has anticancer activity in vitro and in vivo. although curcumin possesses chemopreventive properties against several types of cancer, the molecular mechanisms by which it inhibits cell growth and induces apoptosis are not clearly understood. our data revealed that curcumin inhibited growth and induced apoptosis in androgen-dependent and -independent prostate cancer cells, but had no effect on ... | 2007 | 17332930 |
| possible neuroprotective mechanisms of curcumin in attenuating 3-nitropropionic acid-induced neurotoxicity. | 3-nitropropionic acid (3-np) is a well known fungic toxin causing neurotoxicity. systemic administration of 3-np causes motor and cognitive deficits that are associated with excessive free radical generation. recently, curcumin has been implicated as a neuroprotectant in the treatment of various neurological disorders. the present study was designed to investigate the effects of curcumin in 3-np-induced cognitive impairment and oxidative stress in rats. curcumin, a potent antioxidant of dietary ... | 2007 | 17344940 |
| preparation of an enteric-soluble solid-state emulsion using oily drugs. | to improve the patient's compliance and enhance the stability of oily drugs in the gastric fluid, an enteric-soluble solid-state emulsion (ese), was developed. the ese was prepared by spreading liquid o/w-emulsions on a flat glass and drying at the oven maintained at 40 degrees c. aerosil 200 was applied as solid carrier and emulsifier. and eudragit l30d-55 was used as enteric coating material. the influence of various preparation parameters on the residual volatile oil and the release behavior ... | 2007 | 17349753 |
| prevention of liver cirrhosis in rats by curcumin. | curcumin, the major polyphenolic compound in turmeric, has been shown to attenuate hepatic damage in several animal models of liver injury. the aim of the present study was to examine the efficacy of curcumin in preventing thioacetamide-induced cirrhosis and to unravel the mechanism of curcumin's effect on hepatic fibrosis in rats. | 2007 | 17355460 |
| curcuma longa as feed additive in broiler birds and its patho-physiological effects. | broiler birds (vencob chicken of 3 days old) when given feed mixed with powdered rhizome of curcuma longa (cl; @ 1 g/kg) for 42 days of age, showed significant decrease in serum uric acid and albumin as compared to control, whereas significant increase was recorded in the level of serum total protein and globulin. level of serum glucose, alkaline phosphatase, aspartate amino transferase and calcium showed no significant variation between the two groups. micronutrient assay revealed significantly ... | 2007 | 17373373 |
| curcumin induces electrical activity in rat pancreatic beta-cells by activating the volume-regulated anion channel. | curcumin, the principal active component of turmeric, is reported to exert a number of therapeutic actions, including a hypoglycaemic/antidiabetic action. the underlying mechanisms to this action are essentially unknown. we have investigated the hypothesis that a direct stimulatory action on the pancreatic beta-cell could contribute towards the hypoglycaemic activity of this compound. electrical and ion channel activity were recorded in rat beta-cells using the patch-clamp technique. beta-cell v ... | 2007 | 17382910 |
| oral bioavailability of curcumin in rat and the herbal analysis from curcuma longa by lc-ms/ms. | this study presents a validated liquid chromatography technique coupled with tandem mass spectrometry (lc-ms/ms) to measure curcumin in rat plasma and provide curcuminoids analysis from the extract of curcumin longa l. this method was applied to investigate the pharmacokinetics of curcumin in a freely moving rat. the analytes were separated by a reversed phase c18 column (150x4.6 mm i.d., particle size 5 microm) and eluted with acetonitrile-1mm hcooh mobile phase (70:30, v/v) with a flow rate of ... | 2007 | 17400527 |
| antineoplastic and anticlastogenic properties of curcumin. | curcumin is the pigment of turmeric and has been reported as a signal transduction modulator and inhibitor of transcription factors, for example, nf-kappab. in our article we found a concentration-dependent cytotoxic activity of curcumin in a panel of eight leukemic cell lines (skw-3, cem, u-937, hl-60, hl-60/dox, k-562, lama-84, and ar-230). additive to synergistic interactions was recorded for combinations with bendamustine and idarubicine in skw-3 and lama-84 cells. noteworthy, in multiple my ... | 2007 | 17404048 |
| low concentrations of curcumin induce growth arrest and apoptosis in skin keratinocytes only in combination with uva or visible light. | it is well known that curcumin, a dietary pigment from the plant curcuma longa, inhibits cell proliferation and induces apoptosis in different cell lines at concentrations ranging from 10 to 150 microm (3.7-55 microg/ml). in this study, we show that curcumin at low concentrations (0.2-1 microg/ml) also has an antiproliferative effect when applied in combination with uva or visible light. we demonstrate that such a treatment induces apoptosis in human skin keratinocytes represented by the increas ... | 2007 | 17410200 |
| zerumbone suppresses phorbol ester-induced expression of multiple scavenger receptor genes in thp-1 human monocytic cells. | unregulated uptake of oxidized low-density lipoproteins (ox-ldl) via macrophage scavenger receptors (srs), such as lectin-like ox-ldl receptor-1 (lox-1), is a key event in atherosclerosis. in the present study, we used differentiated caco-2 cells as a model of the human small intestine to evaluate the suppressive effects of 16 traditional food items selected from okinawa on 12-o-tetradecanoylphorbol-13-acetate (tpa)-induced lox-1 mrna expression in thp-1 human monocyte-like cells. three zingiber ... | 2007 | 17420607 |
| kumkum-induced dermatitis: an analysis of 46 cases. | kumkum is a commonly used cosmetic in india, traditionally based on turmeric powder, and its ingredients can cause various types of dermatosis. we undertook a study to characterize kumkum-induced dermatitis clinically and to identify by patch testing the allergens involved. in total, 46 patients with kumkum-induced dermatitis (mean age of these cases 46.5 years; female : male ratio 1.8 : 1) were investigated. the forehead was the most commonly involved site (31/46), followed by the glabellar are ... | 2007 | 17425647 |
| molecular interactions between dimethoxycurcumin and pamam dendrimer carriers. | dimethoxycurcumin, a lipophilic analog of curcumin found as a major pigment in the indian species turmeric (curcuma longa linn.), is known to possess significant activity against various cancer cell lines, but its use as an anticancer drug is hindered by its poor water solubility. the conjugation of dimethoxycurcumin to water-soluble pamam dendrimers (generations 3.5 and 4) is demonstrated. the maximum drug-dendrimer incorporation efficiency is 4.3 and 5.0 molar for g3.5 and g4, respectively. th ... | 2007 | 17428628 |
| curcumin prevents the development of dextran sulfate sodium (dss)-induced experimental colitis. | curcumin is a phenolic natural product isolated from the rhizome of curcuma longa (turmeric). we evaluated the effects of curcumin on the development of dextran sulfate sodium (dss)-induced experimental colitis. balb/c mice were fed a chow containing either 3.5% (wt/wt) dss or 3.5% dss + 2.0% (wt/wt) curcumin. the body weight loss was more apparent in dss-treated mice than in dss + curcumin-treated mice. the disease activity index, histological colitis score, and mpo activity were all significan ... | 2007 | 17429738 |
| curcumin-induced genotoxicity and antigenotoxicity in hepg2 cells. | curcumin, a polyphenolic yellow pigment found in turmeric, is commonly used as a coloring agent in foods, drugs, and cosmetics. in our previous study, we found that low levels of curcumin did not increase the reactive oxygen species (ros) formation and caused no damage to dna in human hepatoma g2 (hepg2) cells, but at high doses, curcumin imposed oxidative stress and damaged dna. in the present study, we are determined to investigate the genotoxic and antigenotoxic effects of curcumin using hepg ... | 2007 | 17433396 |
| inhibition of human recombinant cytochrome p450s by curcumin and curcumin decomposition products. | curcumin (diferuloylmethane) is a major yellow pigment and dietary component derived from curcuma longa. it has potent anti-inflammatory, anticarcinogenic, antioxidant and chemoprotective activities among others. we studied the interactions of curcumin, a mixture of its decomposition products, and four of its individually identified decomposition products (vanillin, vanillic acid, ferulic aldehyde and ferulic acid) on five major human drug-metabolizing cytochrome p450s (cyps). curcumin inhibited ... | 2007 | 17433521 |
| in vitro assessment of curcumin against murine neuroblastoma cells. | neuroblastoma (nb) is a well-known malignant disease in infants, which comprises 10% of childhood malignancies. despite recent advances in understanding the neuro-oncology, nb still accounts for more death in childhood than any other cancer. research in childhood tumors should not only be focused on the malignant signatures of cancer cells but also novel drug prototypes using phytochemicals. the present study was aimed to determine the role of curcumin against murine neuroblastoma cell line (n2a ... | 2007 | 17435663 |
| polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy. | curcumin, a yellow polyphenol extracted from the rhizome of turmeric (curcuma longa), has potent anti-cancer properties as demonstrated in a plethora of human cancer cell line and animal carcinogenesis models. nevertheless, widespread clinical application of this relatively efficacious agent in cancer and other diseases has been limited due to poor aqueous solubility, and consequently, minimal systemic bioavailability. nanoparticle-based drug delivery approaches have the potential for rendering ... | 2007 | 17439648 |
| curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappab-regulated gene products. | gemcitabine is currently the best treatment available for pancreatic cancer, but the disease develops resistance to the drug over time. agents that can either enhance the effects of gemcitabine or overcome chemoresistance to the drug are needed for the treatment of pancreatic cancer. curcumin, a component of turmeric (curcuma longa), is one such agent that has been shown to suppress the transcription factor nuclear factor-kappab (nf-kappab), which is implicated in proliferation, survival, angiog ... | 2007 | 17440100 |
| curcumin for chemoprevention of colon cancer. | the most practical approach to reduce the morbidity and mortality of cancer is to delay the process of carcinogenesis through the use of chemopreventive agents. this necessitates that safer compounds, especially those derived from natural sources must be critically examined for chemoprevention. a spice common to india and the surrounding regions, is turmeric, derived from the rhizome of curcuma longa. pre-clinical studies in a variety of cancer cell lines including breast, cervical, colon, gastr ... | 2007 | 17448598 |
| curcumin activates human glutathione s-transferase p1 expression through antioxidant response element. | curcumin is a plant-derived diferuloylmethane compound extracted from curcuma longa, possessing antioxidative and anticarcinogenic properties. antioxidants and oxidative stress are known to induce the expression of certain classes of detoxification enzymes. since the upregulation of detoxifying enzymes affects the drug metabolism and cell defense system, it is important to understand the gene regulation by such agents. in this study, we demonstrated that curcumin could induce the expression of h ... | 2007 | 17449203 |
| curcuma longa extract as a histological dye for collagen fibres and red blood cells. | crude ethanolic extract and column chromatographic fractions of the allepey cultivar of curcuma longa roxb, commonly called turmeric (tumeric) in commerce, were used as a stain for tissue sections. staining was carried out under basic, acidic and neutral media conditions. inorganic and organic dissolution solvents were used. the stain was used as a counterstain after alum and iron haematoxylins. c. longa stained collagen fibres, cytoplasm, red blood cells and muscle cells yellow. it also stained ... | 2007 | 17451535 |
| the relaxant effect of curcumin on porcine coronary arterial ring segments. | curcumin is a naturally occurring phenolic compound isolated as a yellow pigment from turmeric (curcuma longa). this compound has received much attention due to its diversity of biological and pharmacological activities. the purpose of this study was to assess the effect of curcumin on porcine coronary arteries and to investigate the mechanism of its action, if any. the isometric tension of coronary arterial rings taken from porcine hearts was measured and its response to curcumin (10(-11)-10(-5 ... | 2007 | 17459781 |
| the safety and efficacy of a dietary herbal supplement and gallic acid for weight loss. | the objective of this study was to test the safety and efficacy of nt, a dietary herbal supplement made from rhubarb, ginger, astragulus, red sage, and turmeric, combined with gallic acid (ga) to reduce food intake and cause weight loss. a total of 105 healthy subjects, 18-60 years old with a body mass index of 25-35 kg/m(2) and on no chronic medication, were randomized to a 300 mg/1.2 g nt-ga combination, a 600 mg/2.4 g nt-ga combination, or placebo in three divided doses daily for 24 weeks. fo ... | 2007 | 17472485 |
| drastic effect of several caffeic acid derivatives on the induction of heme oxygenase-1 expression revealed by quantitative real-time rt-pcr. | among antioxidative polyphenols, caffeic acid esters such as caffeic acid phenethyl ester (cape) and chlorogenic acid are contained in propolis, vegetables and coffee. in this study, we compared the efficacy of some polyphenols on the activation level of a cytoprotective heme oxygenase-1 (ho-1) gene in raw264.7 mouse macrophage cells using quantitative real-time rt-pcr. the quantitative study revealed a variety of activation level of ho-1 gene by the chemicals. cape and caffeic acid ethyl ester ... | 2006 | 17473375 |
| natural products as a gold mine for arthritis treatment. | arthritis, an inflammation of the joints, is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines (e.g. tumour necrosis factor and interleukin-1beta) and pro-inflammatory enzymes that mediate the production of prostaglandins (e.g. cyclooxygenase-2) and leukotrienes (e.g. lipooxygenase), together with the expression of adhesion molecules and matrix metalloproteinases, and hyperproliferation of synovial fibroblasts. all of these factors are regulated by the activ ... | 2007 | 17475558 |
| a curcumin-based 1-week triple therapy for eradication of helicobacter pylori infection: something to learn from failure? | curcumin is the principal element of turmeric powder extracted from the root of curcuma longa. studies on curcumin have demonstrated some anti-helicobacter pylori activity as well as immunomodulating properties. n-acetylcysteine and lactoferrin with their respective mucolytic and antibacterial activities might also be effective in h. pylori eradication therapy. | 2007 | 17493004 |
| keratinocyte proliferation, differentiation, and apoptosis--differential mechanisms of regulation by curcumin, egcg and apigenin. | we have proposed that it is important to examine the impact of chemopreventive agents on the function of normal human epidermal keratinocytes since these cells comprise the barrier that protects the body from a range of environmental insults. in this context, it is widely appreciated that cancer may be retarded by consumption or topical application of naturally occurring food-derived chemopreventive agents. our studies show that (-)-epigallocatechin-3-gallate (egcg), a green tea-derived polyphen ... | 2007 | 17493651 |
| diabetic retinopathy: an indian perspective. | diabetic retinopathy (dr) can be defined as damage to microvascular system in the retina due to prolonged hyperglycaemia. the prevalence of dr in the chennai urban rural epidemiology (cures) eye study in south india was 17.6 per cent, significantly lower than age-matched western counterparts. however, due to the large number of diabetic subjects, dr is likely to pose a public health burden in india. cures eye study showed that the major systemic risk factors for onset and progression of dr are d ... | 2007 | 17496357 |
| potential of plant extracts in combination with bacterial antagonist treatment as biocontrol agent of red rot of sugarcane. | plant extracts and antifungal microorganisms were tested singly and in combination for biocontrol of sugarcane red rot disease (colletotrichum falcatum) using two sugarcane (saccharum officinarum l.) cultivars, coc671 and coc92061, in pot and field experiments. leaf extracts of abrus precatorius and bassia latifolia and the rhizome extract of curcuma longa reduced colletotrichum falcatum mycelial growth by 80%, 58%, and 57%, respectively. although sugarcane- planting materials (setts) treated in ... | 2007 | 17496967 |
| curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ros-independent mechanism. | curcumin, a component of turmeric (curcuma longa), has been shown to exhibit chemopreventive activity. whether analogs of curcumin (cur), such as demethoxycurcumin (dmc), bisdemethoxycurcumin (bdmc), tetrahydrocurcumin (thc) and turmerones, modulate inflammatory signaling and cell proliferation signaling to same extent as curcumin was investigated. the results indicate that the relative potency for suppression of tumor necrosis factor (tnf)-induced nuclear factor-kappab (nf-kappab) activation wa ... | 2007 | 17522064 |
| effects of curcumin on peroxisome proliferator-activated receptor gamma expression and nuclear translocation/redistribution in culture-activated rat hepatic stellate cells. | the function of peroxisome proliferator-activated receptor gamma (ppargamma) in hepatic fibrogenesis remains largely unknown. curcumin is a natural substance extracted form curcuma longa linn and has a variety of pharmacological effects. in this study, the effects of curcumin on the proliferation, activation and apoptosis of rat hepatic stellate cells (hscs) through ppargamma signaling were investigated. | 2007 | 17531121 |
| carbohydrate metabolism in dioscorea esculenta (lour.) burk. tubers and curcuma longa l. rhizomes during two phases of dormancy. | we have examined the changes in carbohydrate metabolism in food yam (dioscorea esculenta (lour.) burk.) tubers and in an economically important spice cum medicinal plant turmeric (curcuma longa l.) rhizomes under storage. both specimens showed varied levels of dormancy and sprouting appeared at the end of dormant period. harvested, fully matured tubers of yam and rhizomes of turmeric were stored in wooden boxes under the conditions of 28+/-2 degrees c temperature and 65-75% relative humidity (rh ... | 2007 | 17531451 |
| dietary curcumin does not protect kidney in glycerol-induced acute renal failure. | generation of reactive oxygen species significantly contribute to the pathogenesis of renal injury induced by myoglobin release. the present study was performed to investigate the effects of dietary curcumin, a natural antioxidant isolated from plant curcuma longa, in an experimental model of myoglobinuric acute renal failure. rats received curcumin at an oral dose of 100mg/kg/day for 30 days. renal injury was induced with injection of hypertonic glycerol (10 ml/kg 50% solution) in hind limb mus ... | 2007 | 17532108 |
| regulation of heme oxygenase-1 expression by demethoxy curcuminoids through nrf2 by a pi3-kinase/akt-mediated pathway in mouse beta-cells. | curcumin (diferuloylmethane), a component of turmeric, has been shown to have therapeutic properties. induction of phase 2 detoxifying enzymes is a potential mechanism through which some of the actions of curcumin could proceed. heme oxygenase-1 (ho-1), an antioxidant phase 2 enzyme, has been reported to have cytoprotective effects in pancreatic beta-cells. curcumin on further purification yields demethoxy curcumin (dmc) and bisdemethoxy curcumin (bdmc). the objective of the present study was to ... | 2007 | 17535857 |
| health risk assessment of villagers who live near a lead mining area: a case study of klity village, kanchanaburi province, thailand. | this was a cross-sectional study aimed at assessing environmental lead exposure and its association with blood lead levels, teeth lead levels and iq of the inhibitants who live near lead mining in kanchanaburi province, thailand. two hundred fifteen villagers from 6 villages participated in this study. exposed and non-exposed villagers were asked to perform iq tests based on raven's standard progressive matrices. environmental, blood and tooth samples were collected and analyzed to determine an ... | 2007 | 17539264 |
| new sesquiterpenes and calebin derivatives from curcuma longa. | one novel sesquiterpene with new skeleton, (6s)-2-methyl-6-(4-hydroxyphenyl-3-methyl)-2-hepten-4-one (1), two new bisabolane sesquiterpenes, (6s)-2-methyl-6-(4-hydroxyphenyl)-2-hepten-4-one (2), (6s)-2-methyl-6-(4-formylphenyl)-2-hepten-4-one (3), and two calebin derivatives, 4''-(4'''-hydroxyphenyl-3'''-methoxy)-2''-oxo-3''-butenyl-3-(4'-hydroxyphenyl)-propenoate (4) and 4''-(4'''-hydroxyphenyl)-2''-oxo-3''-butenyl-3-(4'-hydroxyphenyl-3'-methoxy)-propenoate (5) were isolated along with five kno ... | 2007 | 17541200 |
| curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappab pathway. | curcumin, a component of turmeric, has been shown to suppress inflammation and angiogenesis largely by inhibiting the transcription factor nuclear factor-kappab (nf-kappab). this study evaluates the effects of curcumin on ovarian cancer growth using an orthotopic murine model of ovarian cancer. | 2007 | 17545551 |
| curcumin in cell death processes: a challenge for cam of age-related pathologies. | curcumin, the yellow pigment from the rhizoma of curcuma longa, is a widely studied phytochemical which has a variety of biological activities: anti-inflammatory and anti-oxidative. in this review we discuss the biological mechanisms and possible clinical effects of curcumin treatment on cancer therapy, and neurodegenerative diseases such as alzheimer's disease, with particular attention to the cell death processes induced by curcumin. since oxidative stress and inflammation are major determinan ... | 2007 | 17549234 |
| curcumin suppressed anti-apoptotic signals and activated cysteine proteases for apoptosis in human malignant glioblastoma u87mg cells. | glioblastoma is the most malignant human brain tumor that shows poor response to existing therapeutic agents. search continues for an effective therapy for controlling this deadliest brain tumor. curcumin (ccm), a polyphenolic compound from curcuma longa, possesses anti-cancer properties in both in vitro and in vivo. in the present investigation, we evaluated the therapeutic efficacy of ccm against human malignant glioblastoma u87mg cells. trypan blue dye exclusion test showed decreased viabilit ... | 2007 | 17562168 |
| curcumin: the indian solid gold. | turmeric, derived from the plant curcuma longa, is a gold-colored spice commonly used in the indian subcontinent, not only for health care but also for the preservation of food and as a yellow dye for textiles. curcumin, which gives the yellow color to turmeric, was first isolated almost two centuries ago, and its structure as diferuloylmethane was determined in 1910. since the time of ayurveda (1900 bc) numerous therapeutic activities have been assigned to turmeric for a wide variety of disease ... | 2007 | 17569205 |
| antioxidant and anti-inflammatory properties of curcumin. | curcumin, a yellow pigment from curcuma longa, is a major component of turmeric and is commonly used as a spice and food-coloring agent. it is also used as a cosmetic and in some medical preparations. the desirable preventive or putative therapeutic properties of curcumin have also been considered to be associated with its antioxidant and anti-inflammatory properties. because free-radical-mediated peroxidation of membrane lipids and oxidative damage of dna and proteins are believed to be associa ... | 2007 | 17569207 |
| modulation of transcription factors by curcumin. | curcumin is the active ingredient of turmeric that has been consumed as a dietary spice for ages. turmeric is widely used in traditional indian medicine to cure biliary disorders, anorexia, cough, diabetic wounds, hepatic disorders, rheumatism, and sinusitis. extensive investigation over the last five decades has indicated that curcumin reduces blood cholesterol, prevents low-density lipoprotein oxidation, inhibits platelet aggregation, suppresses thrombosis and myocardial infarction, suppresses ... | 2007 | 17569208 |
| cancer chemopreventive effects of curcumin. | chemoprevention, which is referred to as the use of nontoxic natural or synthetic chemicals to intervene in multistage carcinogenesis, has emerged as a promising and pragmatic medical approach to reduce the risk of cancer. numerous components of edible plants, collectively termed "phytochemicals" have been reported to possess substantial chemopreventive properties. curcumin, a yellow coloring ingredient derived from curcuma longa l. (zingiberaceae), is one of the most extensively investigated an ... | 2007 | 17569209 |
| regulation of cox and lox by curcumin. | turmeric (curcuma longa) is extensively used as a household remedy for various diseases. for the last few decades, work has been done to establish the biological activities and pharmacological actions of curcumin, the principle constituent of turmeric. curcumin has proven to be beneficial in the prevention and treatment of a number of inflammatory diseases due to its anti-inflammatory activity. arachidonic acid-derived lipid mediators that are intimately involved in inflammation are biosynthesiz ... | 2007 | 17569213 |
| cell growth regulation. | curcumin, the active ingredient of turmeric (curcuma longa) used in culinary and medical practices in asia, has immense potential for being used in cancer chemotherapy because of its control over the cell growth regulatory mechanisms. the present chapter throws light on the role of curcumin in modulating the various phases of the cell cycle and its apoptosis-inducing effects. this is followed by a discussion on the implications of these effects of curcumin for its use as a chemotherapeutic agent ... | 2007 | 17569215 |
| radioprotection and radiosensitization by curcumin. | this chapter gives an overview of the radioprotective and radiosensitizing effect of curcumin. ionizing radiations interact with biological molecules inducing radiolytic products like e(aq), *oh, *h, -oh, +h, o2, and peroxides. these free radicals damage important biomolecules and subsequently inflict deleterious effects in the organism. whole-body exposure to ionizing radiations results in central nervous system, gastrointestinal tract, and bone marrow syndromes, whereas chronic irradiation cau ... | 2007 | 17569217 |
| immunomodulation by curcumin. | turmeric, the bright yellow spice extracted from the tuberous rhizome of the plant curcuma longa, has been used in traditional indian and chinese systems of medicine for centuries to treat a variety of ailments, including jaundice and hepatic disorders, rheumatism, anorexia, diabetic wounds, and menstrual difficulties. most of the medicinal effects of turmeric have been attributed to curcumin, the principal curcumanoid found in turmeric. recent evidence that curcumin exhibits strong anti-inflamm ... | 2007 | 17569218 |
| beneficial role of curcumin in skin diseases. | in recent years, considerable interest has been focused on curcumin a compound, isolated from turmeric. curcumin is used as a coloring, flavoring agent and has been traditionally used in medicine and cuisine in india. the varied biological properties of curcumin and lack of toxicity even when administered at higher doses makes it attractive to explore its use in various disorders like tumors of skin, colon, duodenum, pancreas, breast and other skin diseases. this chapter reviews the data on the ... | 2007 | 17569219 |
| cardioprotective effects of curcumin. | curcumin, a major active component of turmeric, is extracted from the powdered dry rhizome of curcuma longa linn (zingiberaceae) and it has been used for centuries in indigenous medicine. we have shown that curcumin has a protective role against myocardial necrosis in rats. the antioxidant activity of curcumin could be attributed to the phenolic and methoxy groups in conjunction with the 1,3-diketone-conjugated diene system, for scavenging of the oxygen radicals. in addition, curcumin is shown t ... | 2007 | 17569220 |
| protection from acute and chronic lung diseases by curcumin. | the aim of this review has been to describe the current state of the therapeutic potential of curcumin in acute and chronic lung injuries. occupational and environmental exposures to mineral dusts, airborne pollutants, cigarette smoke, chemotherapy, and radiotherapy injure the lungs, resulting in acute and chronic inflammatory lung diseases. despite major advances in treating lung diseases, until now disease-modifying efficacy has not been demonstrated for any of the existing drugs. current medi ... | 2007 | 17569221 |
| curcumin and autoimmune disease. | the immune system has evolved to protect the host from microbial infection; nevertheless, a breakdown in the immune system often results in infection, cancer, and autoimmune diseases. multiple sclerosis, rheumatoid arthritis, type 1 diabetes, inflammatory bowel disease, myocarditis, thyroiditis, uveitis, systemic lupus erythromatosis, and myasthenia gravis are organ-specific autoimmune diseases that afflict more than 5% of the population worldwide. although the etiology is not known and a cure i ... | 2007 | 17569223 |
| pharmacokinetics and pharmacodynamics of curcumin. | curcuma spp. contain turmerin, essential oils, and curcuminoids, including curcumin. curcumin [1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] is regarded as the most biologically active constituent of the spice turmeric and it comprises 2-8% of most turmeric preparations. preclinical data from animal models and phase i clinical studies performed with human volunteers and patients with cancer have demonstrated low systemic bioavailability following oral dosing. efficient first-pass ... | 2007 | 17569224 |
| natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-part 1. | an integrative approach for managing a patient with cancer should target the multiple biochemical and physiologic pathways that support tumour development and minimize normal-tissue toxicity. angiogenesis is a key process in the promotion of cancer. many natural health products that inhibit angiogenesis also manifest other anticancer activities. the present article focuses on products that have a high degree of anti-angiogenic activity, but it also describes some of the many other actions of the ... | 2006 | 17576437 |
| natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-part 2. | the herbalist has access to hundreds of years of observational data on the anticancer activity of many herbs. laboratory studies are expanding the clinical knowledge that is already documented in traditional texts. the herbs that are traditionally used for anti-cancer treatment and that are anti-angiogenic through multiple interdependent processes (including effects on gene expression, signal processing, and enzyme activities) include artemisia annua (chinese wormwood), viscum album (european mi ... | 2006 | 17576449 |
| immunostimulating activity of crude polysaccharide extract isolated from curcuma xanthorrhiza roxb. | curcuma xanthorrhiza roxb., commonly known as javanese turmeric, has been reported to possess a variety of biological activities, including anti-inflammatory effects, anticarcinogenic effects, wound healing effects, and serum cholesterol-lowering effects. cpe, crude polysaccharide extract isolated from the rhizome of c. xanthorrhiza using 0.1 n naoh, consisted of arabinose (18.69%), galactose (14.0%), glucose (50.67%), mannose (12.97%), rhamnose (2.73%), and xylose (0.94%), with an average molec ... | 2007 | 17587672 |
| effects of four indian medicinal herbs on isoniazid-, rifampicin- and pyrazinamide-induced hepatic injury and immunosuppression in guinea pigs. | to evaluate and compare the hepatoprotective and immunomodulatory effects of curcuma longa (cl), ocimum sanctum (os), tinospora cordifolia (tc) and zizyphus mauritiana (zm) on liver injury and immunosuppression induced by isoniazid (inh), rifampicin (rif) and pyrazinamide (pza). | 2007 | 17589898 |
| standardization and stability studies of neuroprotective lipid soluble fraction obtained from curcuma longa. | the lipid soluble fraction of curcuma longa, i.e. herbal medicament (hm) was isolated from rhizome of curcuma longa by solvent extraction method. the identification of chemical constituent present in hm was done with gc, gc-ms. the standardization of hm was done using hplc method on the basis of three-marker compound isolated, i.e. ar-turmerone, turmerone and curlone. the effect of temperature, ph and light on stability of marker compounds of hm was studied. the composition of marker compound in ... | 2007 | 17590557 |
| de novo synthesis of glutathione is a prerequisite for curcumin to inhibit hepatic stellate cell (hsc) activation. | on liver injury, quiescent hepatic stellate cells (hsc), the most relevant cell type for hepatic fibrogenesis, become active, characterized by enhanced cell growth and overproduction of extracellular matrix (ecm). oxidative stress facilitates hsc activation and the pathogenesis of hepatic fibrosis. glutathione (gsh) is the most important intracellular antioxidant. we previously showed that curcumin, the yellow pigment in curry from turmeric, significantly inhibited hsc activation. the aim of thi ... | 2007 | 17602960 |
| a randomized, placebo-controlled, double-blind clinical trial of curcuminoids in oral lichen planus. | we studied the efficacy of curcuminoids in the treatment of oral lichen planus (olp), a chronic, mucocutaneous, immunological disease. curcuminoids are components of turmeric (curcuma longa) that have anti-inflammatory activity. turmeric has been used in ayurveda (indian traditional medicine) for centuries. a randomized, double-blind, placebo-controlled trial was conducted. in all, 100 consecutive, eligible patients with olp presenting to the oral medicine clinic at the university of california, ... | 2007 | 17604143 |
| md-2 as the target of curcumin in the inhibition of response to lps. | curcumin is the main constituent of the spice turmeric, used in diet and in traditional medicine, particularly across the indian subcontinent. anti-inflammatory activity and inhibition of lps signaling are some of its many activities. we show that curcumin binds at submicromolar affinity to the myeloid differentiation protein 2 (md-2), which is the lps-binding component of the endotoxin surface receptor complex md-2/tlr4. fluorescence emission of curcumin increases with an absorbance maximum shi ... | 2007 | 17609337 |
| antimutagenic potential of curcumin on chromosomal aberrations in allium cepa. | turmeric has long been used as a spice and food colouring agent in asia. in the present investigation, the antimutagenic potential of curcumin was evaluated in allium cepa root meristem cells. so far there is no report on the biological properties of curcumin in plant test systems. the root tip cells were treated with sodium azide at 200 and 300 microg/ml for 3 h and curcumin was given at 5, 10 and 20 microg/ml for 16 h, prior to sodium azide treatment. the tips were squashed after colchicine tr ... | 2007 | 17610326 |
| antioxidant potential of fluoxetine in comparison to curcuma longa in restraint-stressed rats. | stress plays a potential role in the onset and exacerbation of depression. chronic restraint stress in rats, and psychosocial stress in humans, is implicated in the pathophysiology of mood and anxiety disorders. oxidative damage is an established outcome of restraint stress, which has been suggested to induce many damaging processes contributing to the pathology of stress-induced depression. however, the modulatory role of clinically effective antidepressants, such as fluoxetine, in attenuating ... | 2007 | 17610875 |
| curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1a mrna and brain-derived neurotrophic factor expression in chronically stressed rats. | curcuma longa is a major constituent of xiaoyao-san, the traditional chinese medicine, which has been used to effectively manage stress and depression-related disorders in china. as the active component of curcuma longa, curcumin possesses many therapeutic properties; we have previously described its antidepressant activity in our earlier studies using the chronic unpredictable stress model of depression in rats. recent studies show that stress-induced damage to hippocampal neurons may contribut ... | 2007 | 17617388 |
| [study on the preparation of zedoary turmeric oil spray and its anti-virus effects]. | to prepare the zedoary turmeric oil spray and investigate its anti-virus effects. | 2007 | 17634047 |
| a potential role for the vanilloid receptor trpv1 in the therapeutic effect of curcumin in dinitrobenzene sulphonic acid-induced colitis in mice. | a protective role of the transient potential vanilloid receptor 1 (trpv1) in intestinal inflammation induced by dinitrobenzene sulphonic acid (dnbs) has been recently demonstrated. curcumin, the major active component of turmeric, is also able to prevent and ameliorate the severity of the damage in dnbs-induced colitis. we evaluated the possibility that curcumin (45 mg kg(-1) day p.o. for 2 days before and 5 days after the induction of colitis) was able to reduce dnbs-induced colitis in mice, by ... | 2007 | 17640182 |
| the detection of antibacterial actions of whole herb tinctures using luminescent escherichia coli. | two whole cell escherichia coli luminescent biosensors were used to determine the antibacterial actions of 16 herbal tinctures. these bioassays can detect genotoxic (strain dpd2794) and general oxidative stress (de135) events when challenged with antibacterial substances. many of the herbal tinctures were active against these gram-negative bacteria, affecting their metabolism without, in some cases, arresting cell growth or causing cell death. antibacterial activity ranged from undetectable for ... | 2007 | 17661335 |
| effect of curcumin on hyperglycemia-induced vascular endothelial growth factor expression in streptozotocin-induced diabetic rat retina. | diabetic retinopathy is one of the most devastating microvascular complications of long standing type 1 and type 2 diabetes. neovascularization stimulated by hyperglycemia-mediated induction of vascular endothelial growth factor (vegf) has been implicated in the pathogenesis. various small molecules have been investigated for their ability to inhibit angiogenesis. in this study, we evaluated whether curcumin and its dietary source turmeric can inhibit vegf expression in strepotzotocin (stz)-indu ... | 2007 | 17662242 |
| antihyperglycaemic effect of 'ilogen-excel', an ayurvedic herbal formulation in streptozotocin-induced diabetes mellitus. | 'ilogen-excel', an ayurvedic herbal formulation is composed of eight medicinal plants (curcuma longa, strychnos potatorum, salacia oblonga, tinospora cordifolia, vetivelia zizanioides, coscinium fenestratum, andrographis paniculata and mimosa pudica). the present study evaluates the antihyperglycemic effect of 'ilogen-excel' in streptozotocin induced diabetic rats. rats were rendered diabetic by streptozotocin (stz) (45 mg/kg body weight). oral administration of 'ilogen-excel' (50 mg/kg and 100 ... | 2007 | 17665851 |
| aflatoxin induced hemolysis and its amelioration by turmeric extracts and curcumin in vitro. | the present investigation is an attempt to evaluate the possible ameliorative effect of turmeric extracts/curcumin on aflatoxin induced hemolysis in vitro. blood samples were collected from healthy adult human beings (25-30 years old) in edta vials and were used for preparation of rbc suspension in saline. saline suspension of rbc was treated with aflatoxin (0.5-2.0 microg/ml) with and without turmeric extracts/curcumin (1-100 microg/ml). the results revealed that addition of aflatoxin (0.5-2.0 ... | 2007 | 17665866 |
| curcumin attenuates inflammatory responses of tnf-alpha-stimulated human endothelial cells. | curcumin, a yellow pigment of turmeric in curry, is reported to interfere with nuclear factor (nf)-kappab. this study was designed to investigate the underlying pathway of antiinflammation of curcumin on endothelial cells. human umbilical vein endothelial cells (huvecs) were stimulated with 10 ng/ml tumor necrosis factor (tnf)-alpha. curcumin blocked the activation of nf-kappab by tnf-alpha. curcumin also reduced the intracellular reactive oxygen species (ros), monocyte adhesion, phosphorylation ... | 2007 | 17666914 |
| curcumin induces apoptosis and inhibits prostaglandin e(2) production in synovial fibroblasts of patients with rheumatoid arthritis. | rheumatoid arthritis (ra) is a chronic inflammatory disease that is characterized by hyperplasia of the synovial fibroblasts, which is partly the result of decreased apoptosis. this study investigated the mechanisms through which curcumin, a polyphenolic compound from the rhizome of curcuma longa, exerts its anti-proliferative action in the synovial fibroblasts obtained from patients with ra. exposure of the synovial fibroblasts to curcumin resulted in growth inhibition and the induction of apop ... | 2007 | 17671742 |
| a pilot and feasibility study on the effects of naturopathic botanical and dietary interventions on sex steroid hormone metabolism in premenopausal women. | naturopathic physicians commonly make dietary and/or dietary supplement recommendations for breast cancer prevention. this placebo-controlled, parallel-arm, pilot study tested the effects of two naturopathic interventions over five menstrual cycles on sex steroid hormones and metabolic markers in 40 healthy premenopausal women. the intervention arms were as follows: combination botanical supplement (curcuma longa, cynara scolymus, rosmarinus officinalis, schisandra chinensis, silybum marinum, an ... | 2007 | 17684134 |
| influence of tetrahydrocurcumin on erythrocyte membrane bound enzymes and antioxidant status in experimental type 2 diabetic rats. | curcuma longa (zingiberaceae) has been used traditionally as antidiabetic and has been proven scientifically to possess high antioxidant activity and anticancer properties. the active components of curcuma longa such as curcumin and tetrahydrocurcumin (thc), a major colourless metabolite of curcumin also possesses antidiabetic, antiinflammatory and antioxidant activity. in the present study the effect of thc and curcumin on erythrocyte membrane bound enzymes and antioxidants activity in streptoz ... | 2007 | 17693046 |
| efficient preparation of liposomes encapsulating food materials using lecithins by a mechanochemical method. | in order to evaluate to the feasibility of using lecithins for nanocapsules including functional food materials, liposomes were prepared from different commercially available lecithins (slp-white, slp-pc70 and pl30s) by the bangham method, and their physicochemical properties were examined by using a confocal laser scanning microscopy (clsm) and the measurements of trapping efficiency. there was little difference in the trapping efficiency among the three types of liposomes. in all cases, the tr ... | 2006 | 17693697 |
| curcumin induces apoptosis through mitochondrial hyperpolarization and mtdna damage in human hepatoma g2 cells. | curcumin, a major pigment of turmeric, is a natural antioxidant possessing a variety of pharmacological activities and therapeutic properties. but its mechanisms are unknown. in our previous study, we found that a 2-h exposure to curcumin induced dna damage to both the mitochondrial dna (mtdna) and the nuclear dna (ndna) in hepg2 cells and that mtdna damage was more extensive than ndna damage. therefore, experiments were initiated to evaluate the role of mtdna damage in curcumin-induced apoptosi ... | 2007 | 17697941 |
| curcumin is a modulator of bilayer material properties. | curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) is the major bioactive compound in turmeric (curcuma longa) with antioxidant, antiinflammatory, anticarcinogenic, and antimutagenic effects. at low mum concentrations, curcumin modulates many structurally and functionally unrelated proteins, including membrane proteins. because the cell membranes' lipid bilayer serves as a gate-keeper and regulator of many cell functions, we explored whether curcumin modifies general bilayer ... | 2007 | 17705403 |
| curcuminoids-cellular uptake by human primary colon cancer cells as quantitated by a sensitive hplc assay and its relation with the inhibition of proliferation and apoptosis. | curcumin, which is a bright orange-yellow pigment of turmeric with antioxidant properties, has been shown to produce a potent preventative action against several types of cancers in recent studies. it has also been reported to protect the development of colon tumor in animals being fed with carcinogen. in the colon cancer cells, curcumin was illustrated to inhibit cell proliferation and induce apoptosis. as an antioxidant, it acts as an anti-inflammatory as well as an antitumor agent. curcumin h ... | 2007 | 17760412 |
| improving the solubility and pharmacological efficacy of curcumin by heat treatment. | lipid peroxidation has been implicated in a variety of diseases. 4-hydroxy-2-nonenal (hne), a major oxidation by-product, is cytotoxic, mutagenic, and genotoxic, being involved in disease pathogenesis. naturally occurring pharmacologically active small molecules are very attractive as natural nonsteroidal anti-inflammatory agents. interest has greatly increased recently in the pharmacotherapeutic potential of curcumin, the yellow pigment found in the rhizomes of the perennial herb curcuma longa ... | 2007 | 17767425 |
| influence of tetrahydrocurcumin on hepatic and renal functional markers and protein levels in experimental type 2 diabetic rats. | curcumin is the most active component of turmeric. it is believed that curcumin is a potent antioxidant and anti-inflammatory agent. tetrahydrocurcumin is one of the major metabolites of curcumin that exhibits many of the same physiologic and pharmacological activities as curcumin and in some systems may exert greater antioxidant activity than curcumin. oral administration of tetrahydrocurcumin at 80 mg/kg body weight to diabetic rats for 45 days resulted in a significant reduction in blood gluc ... | 2007 | 17845505 |
| effect of selected natural dyes in reduction on colour changes of egyptian linen textiles by fungi. | linen is the most historical egyptian textile fibre liable to fungal deterioration. fungal deterioration of dyed linen textiles may appear as undesirable different stains. in order to success in removing of fungal stains from biodeteriorated historical egyptian dyed linen textiles, it is necessary to understand the nature and causes of these stains, hence their subsequent removal. so this paper aims to investigate the effect of fungi on dyed linen textiles. in this study linen textile samples we ... | 2007 | 17867537 |
| curcumin suppresses the transformation of an aryl hydrocarbon receptor through its phosphorylation. | halogenated and polycyclic aromatic hydrocarbons induce diverse biochemical responses through the transformation of a cytosolic aryl hydrocarbon receptor (ahr). in mouse hepatoma hepa-1c1c7 cells, curcumin, a yellow pigment of curcuma longa, did not inhibit the 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd)-induced translocation of the ahr into the nucleus, but rather accelerated it. in the nucleus, curcumin inhibited the tcdd-induced heterodimerization of the ahr with an ahr nuclear translocator (a ... | 2007 | 17880909 |
| repellent activity of essential oils against cockroaches (dictyoptera: blattidae, blattellidae, and blaberidae) in thailand. | seven commercial essential oils extracted from the plant species boesenbergia rotunda (l.) mansf., citrus hystrix dc., curcuma longa l., litsea cubeba (lour.) pers., piper nigrum l., psidium guajava l. and zingiber officinale roscoe, and naphthalene as a control, were evaluated for repellent activity against the three cockroach species periplaneta americana (l.), blattella germanica (l.) and neostylopyga rhombifolia (stoll) under laboratory conditions. the essential oil derived from citrus hystr ... | 2007 | 17883004 |
| herbal mixtures consisting of puerarin and either polyenylphosphatidylcholine or curcumin provide comprehensive protection against alcohol-related disorders in p rats receiving free choice water and 15% ethanol in pure water. | chronic alcohol drinking has been associated with the development of a number of abnormalities, including neuron-behavioral disorders, liver, pancreas, and heart-related diseases and inflammation and immune disorders. because diverse mechanisms are involved in the development of these disorders, the commonly used receptor- or enzyme-specific drugs do not provide comprehensive protection against the adverse effects of alcoholism. this study describes possible therapeutic potency of puerarin (pu) ... | 2007 | 17887948 |
| curcumin contributes to in vitro removal of non-transferrin bound iron by deferiprone and desferrioxamine in thalassemic plasma. | non-transferrin-bound iron (ntbi) is detectable in plasma of beta-thalassemia patients with transfusional iron overload. this form of iron may cause oxidative tissue damage and increased iron uptake, into several vital organs. removal of ntbi species is incomplete and transient using standard intermittent desferrioxamine (dfo) or deferiprone (dfp) monotherapy. combinations of these or other chelators may improve the protection time from ntbi and increase removal of harmful ntbi species. curcumin ... | 2007 | 17897073 |
| curcumin as "curecumin": from kitchen to clinic. | although turmeric (curcuma longa; an indian spice) has been described in ayurveda, as a treatment for inflammatory diseases and is referred by different names in different cultures, the active principle called curcumin or diferuloylmethane, a yellow pigment present in turmeric (curry powder) has been shown to exhibit numerous activities. extensive research over the last half century has revealed several important functions of curcumin. it binds to a variety of proteins and inhibits the activity ... | 2008 | 17900536 |
| antischistosomal and liver protective effects of curcuma longa extract in schistosoma mansoni infected mice. | with a view to clarify the induction of the "crabtree consequence" in liver cells of s. mansoni infected mice, the curative effect of oil extract of c. longa was tested and compared to praziquantel (pzq) the effective drug against all schistosome species occurring in man. protein, glucose, glucose-6-phopsphatase, amp-deaminase, adensoine deaminase, urea concentration, pyravate kinase (pk), phosphoenol pyruvate carboxykinase (pepck) and pk/pepck ratio were estimated. in addition, worm burden and ... | 2007 | 17907745 |
| knowledge, attitude and practices about animal bites and rabies in general community--a multi-centric study. | rabies a disease as old as our civilization, continues to be the most feared of all communicable diseases. despite the availability the state-of-the-art tools which ensure near cent percent protection against rabies, india is the largest contributant to rabies mortality in the world. a multicentric study was carried out from april 2001 to september 2002 with the objective of assessing the knowledge, attitudes, beliefs and practices (kap) about animal bites and rabies in the general community. th ... | 2006 | 17913213 |