Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| authentication of panax notoginseng by 5s-rrna spacer domain and random amplified polymorphic dna (rapd) analysis. | the great majority of panax species are well-known herbal medicines in the orient, and many of them share a close resemblance in appearance and chemical composition. among these panax species, the root of p. notoginseng (sanqi) is a unique herb that has distinct clinical usage. here, the 5s-rrna spacer domains were isolated from p. notoginseng, p. japonicus var. major, p. stipuleanatus, p. quinquefolius, p. ginseng, p. zingiberensis, and p. wangianus, and four common adulterants of p. notoginsen ... | 2003 | 12865989 |
| antitumor activity of extract of zingiber aromaticum and its bioactive sesquiterpenoid zerumbone. | the anticancer properties of zerumbone (2,6,9 humulatriene-8-one, a sesquiterpenoid) from zingiber aromaticum were compared with those of curcumin from curcuma longa in an in vitro mtt tetrazolium salt assay using ht-29, caco-2, and mcf-7 cancer cells and in an azoxymethane (aom)-induced animal model of colon cancer using aberrant crypt foci (acfs) as a preneoplastic marker. the ic50 of zerumbone was approximately 10 mm and that of curcumin was 25 mm. cell cycle arrest in ht-29 cells was observe ... | 2003 | 12881017 |
| screening pharmaceutical preparations containing extracts of turmeric rhizome, artichoke leaf, devil's claw root and garlic or salmon oil for antioxidant capacity. | pharmaceutical preparations derived from natural sources such as vegetables often contain compounds that contribute to the antioxidant defence system and apparently play a role in the protection against degenerative diseases. in the present study, commercial preparations containing extracts of turmeric, artichoke, devil's claw and garlic or salmon oil were investigated. the products were divided into fractions of different polarity, and their antioxidant activity was determined using the trolox ... | 2003 | 12906755 |
| effects of curcuma drugs on vasomotion in isolated rat aorta. | the effectiveness of curcuma drugs against "oketsu" and the differences in their efficacy were evaluated by examining their vasomotional effects as one index. since nitric oxide (no) is the relaxation factor of vascular smooth muscle and also an inhibitor of platelet aggregation in blood vessels, substances showing no-dependent relaxation are thought to be effective in improving oketsu. in this study, five curcuma drugs derived from curcuma longa, c. kwangsiensis, c. phaeocaulis, c. wenyujin, an ... | 2003 | 12913265 |
| oral administration of a turmeric extract inhibits erythrocyte and liver microsome membrane oxidation in rabbits fed with an atherogenic diet. | the aim of this study was to evaluate the effects of an oral supplementation with a curcuma longa ethanol and aqueous extract on the susceptibility to oxidation of cellular and subcellular membranes affected in the atherosclerotic process, such as erythrocyte membranes and liver microsomes, in rabbits fed with a high-fat diet. | 2003 | 12921893 |
| antispasmodic effects of curcuminoids on isolated guinea-pig ileum and rat uterus. | curcuminoids, a yellow constituent isolated from curcuma longa linn. rhizomes was studied for its antispasmodic activity in isolated guinea-pig ileum and rat uterus. curcuminoids at the concentration of 12 microg/ml significantly inhibited the ileum pre-contracted with acetylcholine (ach) 5 x 10(-7) m and histamine 5 x 10(-7) m. (force of contraction was 62.84 +/- 4.66% and 75.60 +/- 4.66% respectively) and the effects were prominently observed when the concentration of curcuminoids was increase ... | 2003 | 12930003 |
| a chromatographic study of the curcuminoids in curcuma longa, l. | 1953 | 13070173 | |
| inhibitory effect of dibenzoylmethane on mutagenicity of food-derived heterocyclic amine mutagens. | dibenzoylmethane (dbm), a structural analogue of curcumin (a bioactive phytochemical present in a widely used spice turmeric) was screened for its inhibitory effect against seven cooked food mutagens (heterocyclic amines): 2-amino-3-methylimidazo[4,5-f]quinoline (iq), 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (meiq), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (meiqx), 3-amino-1,4-dimethyl-5h-pyrido[4,3-b]indole (trp-p-1), 3-amino-1-methyl-5h-pyrido[4,3-b]indole (trp-p-2), 2-amino-1-methyl-6 ... | 2003 | 13678246 |
| evaluation of nitric oxide scavenging activity of certain spices in vitro: a preliminary study. | the plant extracts of some commonly used spices were examined for their possible regulatory effect on nitric oxide (no) levels using sodium nitroprusside as a no donor in vitro. most of the extracts tested demonstrated direct scavenging of no and exhibited significant activity and the potency of scavenging activity was in the following order: foeniculum vulgare (aqueous) > citrus limettiodes > murraya koenigii (seed, aqueous) > murraya koenigii (leaf, aqueous) > curcuma aromatica (aqueous) > mur ... | 2003 | 13678266 |
| curcumin inhibits uv irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermoid carcinoma a431 cells. | ultraviolet (uv) light is a strong apoptotic trigger that induces caspase-dependent biochemical changes in cells. previously we showed that uv irradiation can activate caspase-3, and the subsequent cleavage and activation of p21(cdc42/rac)-activated kinase 2 (pak2) in human epidermoid carcinoma a431 cells. in this study we demonstrate that curcumin (cur), the yellow pigment of curcuma longa with known anti-oxidant and anti-inflammatory properties, can prevent uv irradiation-induced apoptotic cha ... | 2003 | 14505349 |
| induction of apoptosis by curcumin: mediation by glutathione s-transferase p1-1 inhibition. | expression of glutathione s-transferase p1-1 (gstp1-1) is correlated to carcinogenesis and resistance of cancer cells against chemotherapeutic agents. curcumin, a natural compound extracted from curcuma longa, has shown strong antioxidant and anticancer properties and also the ability to regulate a wide variety of genes that require activating protein 1 and nuclear factor kappab (nf-kappab) activation. in the present study, we examined the inhibitory effect of curcumin on the expression of gstp1 ... | 2003 | 14555224 |
| comparison of yield, composition, and antioxidant activity of turmeric (curcuma longa l.) extracts obtained using various techniques. | turmeric extracts were obtained from two lots of raw material (m and s) using various techniques: hydrodistillation, low pressure solvent extraction, soxhlet, and supercritical extraction using carbon dioxide and cosolvents. the solvents and cosolvents tested were ethanol, isopropyl alcohol, and their mixture in equal proportions. the composition of the extracts was determined by gas chromatography-flame ionization detection (gc-fid) and uv. the largest yield (27%, weight) was obtained in the so ... | 2003 | 14558784 |
| sensitive and rapid isocratic liquid chromatography method for the quantitation of curcumin in plasma. | an hplc assay was developed using three methods of plasma sample preparation in order to quantitate curcumin, the main constituent in the herbal dietary supplement turmeric. each method involves simple and rapid processing of samples (either an ethyl acetate or chloroform extraction) with resulting different quantitation limits for curcumin. the assay was developed in an effort to quantify extremely low curcumin plasma concentrations observed in preliminary in vivo studies. the most sensitive as ... | 2003 | 14581073 |
| extraction of essential oil and pigments from curcuma longa [l] by steam distillation and extraction with volatile solvents. | curcuma longa [linn] (turmeric), of the zingiberaceae family, has a great importance in the food, textile, and pharmaceutical industries. the aim of this work was to identify the best processing conditions to maximize the yields of essential oil and pigments, as well as their content of ar-turmerone, (alpha and beta)-turmerone, and the curcuminoids, respectively. autoclave pressure and distillation time were the variables studied for the steam distillation process. the highest yields of essentia ... | 2003 | 14582978 |
| cancer risk and diet in india. | india is a developing country with one of the most diverse populations and diets in the world. cancer rates in india are lower than those seen in western countries, but are rising with increasing migration of rural population to the cities, increase in life expectancy and changes in lifestyles. in india, rates for oral and oesophageal cancers are some of the highest in the world. in contrast, the rates for colorectal, prostate, and lung cancers are one of the lowest. studies of indian immigrants ... | 2005 | 14597785 |
| biomimetic oxidation of curcumin with hydrogen peroxide catalyzed by 5,10,15,20-tetraarylporphyrinatoiron(iii) chlorides in dichloromethane. | the biomimetic oxidation of curcumin, a main turmeric pigment with hydrogen peroxide catalyzed by different 5,10,15,20-tetraarylporphyrinatoiron(iii) chlorides [tapfe(iii)cl] in dichloromethane has been studied to give a c-c coupled curcumin dimer in 40-70% yield. the structure of the dimer has been elucidated by (1)h-, (13)c-nmr, ir and fab-mass spectroscopic data. | 2003 | 14600390 |
| curcumin inhibits protease-activated receptor-2 and -4-mediated mast cell activation. | curcumin, a major yellow pigment and active component of turmeric powder extracted from curcuma longa l. (gingiberaceae), has been shown to possess anti-inflammatory and anti-cancer activities. protease-activated receptors (pars) play a role in inflammation, and human leukemic mast cells (hmc-1) co-express par2 and par4. in the present study, the effect of curcumin on par2- and par4-mediated hmc-1 activation was examined. | 2003 | 14637278 |
| curcumin-induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. | there is evidence for increased levels of circulating reactive oxygen species (ros) in diabetics, as indirectly inferred by the findings of increased lipid peroxidation and decreased antioxidant status. direct measurements of intracellular generation of ros using fluorescent dyes also demonstrate an association of oxidative stress with diabetes. although phenolic compounds attenuate oxidative stress-related tissue damage, there are concerns over toxicity of synthetic phenolic antioxidants and th ... | 2003 | 14660871 |
| redox regulation of heat shock protein expression in aging and neurodegenerative disorders associated with oxidative stress: a nutritional approach. | oxidative stress has been implicated in mechanisms leading to neuronal cell injury in various pathological states of the brain. alzheimer's disease (ad) is a progressive disorder with cognitive and memory decline, speech loss, personality changes and synapse loss. many approaches have been undertaken to understand ad, but the heterogeneity of the etiologic factors makes it difficult to define the clinically most important factor determining the onset and progression of the disease. however, incr ... | 2003 | 14661103 |
| application of single-nucleotide polymorphism analysis of the trnk gene to the identification of curcuma plants. | we previously found that curcuma plants and drugs derived from curcuma longa, c. phaeocaulis, c. zedoaria, and c. aromatica could be identified by the nucleotide differences at two sites and the existence of a 4-base indel on trnk gene. in this paper, based on species-specific nucleotide sequences, the application of a new method, single-nucleotide polymorphism (snp) analysis was investigated to identify curcuma plants more conveniently. first, three types of reverse primer were synthesized in d ... | 2004 | 14709921 |
| repellency of aromatic turmeric curcuma aromatica under laboratory and field conditions. | three curcuma species, curcuma aeruginosa (pink and blue ginger), cu. aromatica (aromatic turmeric), and cu. xanthorrhiza (giant curcuma), were selected for investigation of mosquito repellent activity. in a laboratory study, a 95% ethanol extract of each plant was tested for repellent activity of aedes togoi on human volunteers. only cu. aromatica extract showed repellency against ae. togoi with ed50 and ed95 values of 0.061 and 1.55 mg/cm2, respectively. it also provided biting protection for ... | 2003 | 14714673 |
| effect of curcuma on radiation-induced apoptosis in human cancer cells. | there have been considerable efforts to search for naturally occurring substances for the intervention of carcinogenesis. many components from dietary or medicinal plants have been identified that possess substantial chemopreventive properties. curcuma, a yellow pigment from curcuma longa, exhibits anti-inflammatory, antitumor, and antioxidative properties. although its precise mode of action has not been elucidated so far, studies have shown that chemopreventive action of curcuma might be due t ... | 2004 | 14719108 |
| hepatobiliary clearance of labelled mebrofenin in normal and d-galactosamine hcl-induced hepatitis rats and the protective effect of turmeric extract. | this study was carried out to see the hepatobiliary clearance of 99m tc-mebrofenin radiopharmaceutical in d-galactosamine induced hepatic rats. furthermore, protective effect of turmeric extract has been studied in these hepatitis rats. hepatitis was induced with intraperitoneal injection of d-galactosamine (400 mg/kg b. wt) in these rats. 1% turmeric extract was given along with their normal diet for 15 days. turmeric extract treatment significantly increased the hepatic uptake of radioactivity ... | 2003 | 14723320 |
| through metal binding, curcumin protects against lead- and cadmium-induced lipid peroxidation in rat brain homogenates and against lead-induced tissue damage in rat brain. | curcumin, the major constituent of turmeric is a known, naturally occurring antioxidant. the present study examined the ability of this compound to protect against lead-induced damage to hippocampal cells of male wistar rats, as well as lipid peroxidation induced by lead and cadmium in rat brain homogenate. the thiobarbituric assay (tba) was used to measure the extent of lipid peroxidation induced by lead and cadmium in rat brain homogenate. the results show that curcumin significantly protects ... | 2004 | 14729307 |
| inhibition of b(a)p induced strand breaks in presence of curcumin. | incidence of cancer at different sites may be related to oxidative damage to host genome by genotoxicants. these oxidative actions may be modified by phytochemicals present in foods. the non-nutritive dietary constituents which possess antimutagenic property appear to be promising chemopreventive agents. this study reports the protective effect of curcumin on b(a)p induced dna damage in human peripheral blood lymphocyte cells. the study group consisted of 10 male smokers, 10 non-smokers and 10 n ... | 2004 | 14729375 |
| suppression by hydrangeae dulcis folium of d-galactosamine-induced liver injury in vitro and in vivo. | hydrangeae dulcis folium, the fermented and dried leaves of hydrangea macrophylla ser. var. thunbergii makino, suppressed d-galactosamine-induced liver injury by 85.2% when added to the diet at 1% and fed to rats for fifteen days. the hepatoprotective effect is more potent than that of a milk thistle extract and turmeric powder. some fractionated extracts showed hepatoprotective activity in the d-galactosamine-induced in vitro liver injury model. | 2003 | 14730144 |
| curcumin-induced apoptosis in scleroderma lung fibroblasts: role of protein kinase cepsilon. | scleroderma, a disease involving excessive collagen deposition, can be studied using fibroblasts cultured from affected tissues. we find that curcumin, the active component of the spice turmeric, causes apoptosis in scleroderma lung fibroblasts (slf), but not in normal lung fibroblasts (nlf). this effect is likely to be linked to the fact that although curcumin induces the expression of the phase 2 detoxification enzymes heme oxygenase 1 and glutathione s-transferase p1 (gst p1) in nlf, slf are ... | 2004 | 14742295 |
| the curcuma antioxidants: pharmacological effects and prospects for future clinical use. a review. | in agreement with the predictions of the oxygen-stress theory of aging and age-related degenerative diseases, diet supplementation with a number of phenolic or thiolic antioxidants has been able to increase the life span of laboratory animals, protect against senescent immune decline and preserve the respiratory function of aged mitochondria. in addition to the above, more recent data reviewed here suggest that the polyphenolic compound curcumin and related non-toxic antioxidants from the rhizom ... | 2002 | 14764309 |
| laccur stain for detection of mucin in adenocarcinoma. | identification of cytoplasmic mucin, usually by mayer's mucicarmine stain, is one of the criteria to diagnose adenocarcinoma. the inexpensive laccur stain, made up of curcuma longa (khamin-shan) and secreta of laccifer lacca (krang) has been introduced. the aim of this study was to compare the mayer's mucicarmine and laccur stains in the detection of mucin material. the specimens included 17 adenocarcinomas of the stomach, 16 of the colon, 18 of the lung, 16 of the breast, and 12 of the bile duc ... | 2004 | 14971540 |
| curcumin confers radiosensitizing effect in prostate cancer cell line pc-3. | curcumin (diferuloylmethane) is a major chemical component of turmeric (curcuma longa) and is used as a spice to give a specific flavor and yellow color in asian food. curcumin exhibits growth inhibitory effects in a broad range of tumors as well as in tpa-induced skin tumors in mice. this study was undertaken to investigate the radiosensitizing effects of curcumin in p53 mutant prostate cancer cell line pc-3. compared to cells that were irradiated alone (sf(2)=0.635; d(0)=231 cgy), curcumin at ... | 2004 | 14985701 |
| protective effect of curcumin against lead neurotoxicity in rat. | curcumin (diferuloylmethane), an active ingredient of turmeric, is known to have multiple activities, including an antioxidant property, and has been suggested to be of use in treatment of several diseases. the present study has been undertaken to investigate the protective effect of curcumin against lead-induced neurotoxicity in rats. exposure of rats to lead (50 mg/kg po) for 45 days caused an increase in lipid peroxidation (lpo) and a decrease in reduced glutathione (gsh) levels in cerebellum ... | 2003 | 14992327 |
| curcumin as a dna topoisomerase ii poison. | curcumin, the major active component of the spice turmeric, is recognised as a safe compound with great potential for cancer chemoprevention and cancer therapy. it induces apoptosis, but its initiation mechanism remains poorly understood. curcumin has been assessed on the human cancer cell lines, tk-10, mcf-7 and uacc-62, and their ic50 values were 12.16, 3.63, 4.28 microm respectively. the possibility of this compound being a topoisomerase ii poison has also been studied and it was found that 5 ... | 2003 | 15008515 |
| curcumin blocks nf-kappab and the motogenic response in helicobacter pylori-infected epithelial cells. | infection of epithelial cells by the microbial pathogen helicobacter pylori leads to activation of the transcription factor nuclear factor kappab (nf-kappab), the induction of pro-inflammatory cytokine/chemokine genes, and the motogenic response (cell scattering). here we report that h. pylori-induced nf-kappab activation and the subsequent release of interleukin 8 (il-8) are inhibited by curcumin (diferuloylmethane), a yellow pigment in turmeric (curcuma longa l.). our results demonstrate that ... | 2004 | 15044093 |
| effect of curcumin on radiation-impaired healing of excisional wounds in mice. | to study the effect on wound contraction of pretreatment with various doses of curcumin (the most important active ingredient of the spice turmeric) in mice exposed to 6 gy whole-body gamma radiation. | 2004 | 15045805 |
| contraceptive effect of curcuma longa (l.) in male albino rat. | to study the contraceptive effect of the crude extracts of curcuma longa in male albino rats. | 2004 | 15064838 |
| curcumin inhibits dose-dependently and time-dependently neuroglial cell proliferation and growth. | curcumin (cur), the active chemical of the asian spice turmeric, has strong anti-oxidant and anti-inflammatory properties. cur inhibits proliferation and growth of several cell types, e.g. cancer cells. while cur inhibitory effects on microglial cells are demonstrated, little is known of its effects on neuroglia, astrocytes (ast) and oligodendrocytes (olg). our work focuses on cur's effects on neuroglial proliferation and growth in vitro, utilizing c-6 rat glioma 2b-clone cells, a mixed colony o ... | 2003 | 15073579 |
| modulation of human multidrug-resistance mdr-1 gene by natural curcuminoids. | multidrug resistance (mdr) is a phenomenon that is often associated with decreased intracellular drug accumulation in patient's tumor cells resulting from enhanced drug efflux. it is related to the overexpression of a membrane protein, p-glycoprotein (pgp-170), thereby reducing drug cytotoxicity. a variety of studies have tried to find mdr modulators which increase drug accumulation in cancer cells. | 2004 | 15090070 |
| anti-apoptotic effects of curcumin on photosensitized human epidermal carcinoma a431 cells. | photodynamic treatment (pdt) can elicit a diverse range of cellular responses, including apoptotic cell death. previously, we showed that pdt stimulates caspase-3 activation and subsequent cleavage and activation of p21-activated kinase 2 (pak2) in human epidermal carcinoma a431 cells. curcumin, the yellow pigment of curcuma longa, is known to have anti-oxidant and anti-inflammatory properties. in the present study, using rose bengal (rb) as the photosensitizer, we investigated the effect of cur ... | 2004 | 15095415 |
| curcumin, a major constituent of turmeric, corrects cystic fibrosis defects. | cystic fibrosis is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (cftr). the most common mutation, deltaf508, results in the production of a misfolded cftr protein that is retained in the endoplasmic reticulum and targeted for degradation. curcumin is a nontoxic ca-adenosine triphosphatase pump inhibitor that can be administered to humans safely. oral administration of curcumin to homozygous deltaf508 cftr mice in doses comparable, on a weight-p ... | 2004 | 15105504 |
| biological properties of curcumin-cellular and molecular mechanisms of action. | curcuminoids, a group of phenolic compounds isolated from the roots of curcuma longa (zingiberaceae), exhibit a variety of beneficial effects on health and on events that help in preventing certain diseases. a vast majority of these studies were carried out with curcumin (diferuloyl methane), which is a major curcuminoid. the most detailed studies using curcumin include anti-inflammatory, antioxidant, anticarcinogenic, antiviral, and antiinfectious activities. in addition, the wound healing and ... | 2004 | 15116757 |
| protective effects of a mixture of dietary agents against 7,12-dimethylbenz[a]anthracene-induced genotoxicity and oxidative stress in mice. | we investigated the effects of pretreatment with tomato, garlic, and turmeric, alone and in combination, against 7,12-dimethylbenz[a]anthracene (dmba)-induced genetic damage and oxidative stress in male swiss mice. measurement of the incidence of bone marrow micronuclei as well as the extent of lipid peroxidation and the status of the antioxidants reduced glutathione, glutathione peroxidase, and glutathione-s-transferase in the liver and erythrocytes were used as biomarkers of chemoprotection. i ... | 2004 | 15117554 |
| spice phenolics inhibit human pmnl 5-lipoxygenase. | a wide variety of phenolic compounds and flavonoids present in spices possess potent antioxidant, antimutagenic and anticarcinogenic activities. we examined whether 5-lipoxygenase (5-lo), the key enzyme involved in biosynthesis of leukotrienes is a possible target for the spices. effect of aqueous extracts of turmeric, cloves, pepper, chili, cinnamon, onion and also their respective active principles viz., curcumin, eugenol, piperine, capsaicin, cinnamaldehyde, quercetin, and allyl sulfide were ... | 2004 | 15120715 |
| curcumin (diferuloylmethane) inhibits receptor activator of nf-kappa b ligand-induced nf-kappa b activation in osteoclast precursors and suppresses osteoclastogenesis. | numerous studies have indicated that inflammatory cytokines play a major role in osteoclastogenesis, leading to the bone resorption that is frequently associated with cancers and other diseases. gene deletion studies have shown that receptor activator of nf-kappab ligand (rankl) is one of the critical mediators of osteoclastogenesis. how rankl mediates osteoclastogenesis is not fully understood, but an agent that suppresses rankl signaling has potential to inhibit osteoclastogenesis. in this rep ... | 2004 | 15128775 |
| bulk and trace element analysis of spices: the applicability of k0-standardization and energy dispersive x-ray fluorescence. | methodology has been developed for the bulk and trace element analysis of spices such as curry powder and turmeric powder originated from sri lanka by the k0-standardization method (inaa-k0) and by energy dispersive x-ray fluorescence (edxrf). srm 1572 citrus leaves was used to check the accuracy of the results obtained by the two nuclear techniques. the elements determined quantitatively in these matrices by the edxrf analysis were bromine, calcium, copper, iron, potassium, magnesium, manganese ... | 2004 | 15139383 |
| modulatory properties of various natural chemopreventive agents on the activation of nf-kappab signaling pathway. | to study and compare effects of selected natural chemopreventive agents on the transcription activation of nuclear factor-kappa b (nf-kappab) in human ht-29 colon cancer cells. | 2004 | 15139523 |
| nutritional antioxidants and the heme oxygenase pathway of stress tolerance: novel targets for neuroprotection in alzheimer's disease. | oxidative stress has been implicated in mechanisms leading to neuronal cell injury in various pathological states of the brain. alzheimer's disease (ad) is a progressive disorder with cognitive and memory decline, speech loss, personality changes and synapse loss. many approaches have been undertaken to understand ad, but the heterogeneity of the etiologic factors makes it difficult to define the clinically most important factor determining the onset and progression of the disease. however, incr ... | 2003 | 15141484 |
| induction of apoptosis in human lung cancer cells by curcumin. | curcumin, a phenolic compound from the rhizome of the plant curcuma longa has anti-inflammatory, antioxidant and anti-cancer activities. although the precise mode of action of this compound is not yet elucidated, studies have shown that chemo-preventive action of curcumin might be due to its ability to induce apoptosis and to arrest cell cycle. this study investigated the cellular and molecular changes induced by curcumin leading to the induction of apoptosis in human lung cancer cell lines-a549 ... | 2004 | 15142674 |
| antimutagenicity of herbal detoxification formula smoke shield against environmental mutagens. | smoke shield is a formulation designed to reduce smoke related mutagenicity and toxicity in the population. smoke shield contains a dual extract of turmeric (curcuma longa) obtained by supercritical co2 gas extraction and post-supercritical hydroethanolic extraction together with extracts of green tea and other spices, whose presence synergistically increases the activity of turmeric. in the present study we have shown its antimutagenic activity to various environmental mutagens in vitro and in ... | 2004 | 15149152 |
| role of curcumin, a naturally occurring phenolic compound of turmeric in accelerating the repair of excision wound, in mice whole-body exposed to various doses of gamma-radiation. | the healing of irradiated wounds has always been a central consideration in medical practice because radiation disrupts normal response to injury, leading to a protracted recovery period. the quest for clinically effective wound healing agents is important in the medical management of irradiated wounds. therefore, the present study was conceptualized to investigate the effect of curcumin (natural yellow, diferuloylmethane), a major yellow pigment and an active component of turmeric on wound heal ... | 2004 | 15172199 |
| patented antiinflammatory plant drug development from traditional medicine. | patents secured on antiinflammatory plant drugs derived from 38 plants are reviewed. an attempt has been made to compare the modern and traditional use of plant drugs and to establish the relevance of folk claims in developing modern drugs. the role of plant botanicals such as polysaccharides, terpenes, curcuminoids, alkaloids, etc. in alleviating inflammatory diseases including arthritis, rheumatism, acne skin allergy and ulcers is highlighted. chemicals that alleviate swelling are derived from ... | 2004 | 15173991 |
| antimicrobial and chemopreventive properties of herbs and spices. | herbs and spices have been used for generations by humans as food and to treat ailments. scientific evidence is accumulating that many of these herbs and spices do have medicinal properties that alleviate symptoms or prevent disease. a growing body of research has demonstrated that the commonly used herbs and spices such as garlic, black cumin, cloves, cinnamon, thyme, allspices, bay leaves, mustard, and rosemary, possess antimicrobial properties that, in some cases, can be used therapeutically. ... | 2004 | 15180577 |
| immunomodulatory activity of curcumin: suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production in vitro. | curcumin (diferuloylmethane), a major curcumanoid found in the spice turmeric, exhibits anti-inflammatory, anti-oxidant, and chemopreventive activities. however, the effect of curcumin on the development of t cell-mediated immunological responses largely remains unknown. in this study we have investigated the effect of curcumin on mitogen/antigen induced proliferation of splenic lymphocytes, induction of cytotoxic t lymphocytes (ctls), lymphokine activated killer (lak) cells, and the production ... | 2004 | 15183117 |
| curcumin blocks multiple sites of the tgf-beta signaling cascade in renal cells. | over-expression of transforming growth factor-beta (tgf-beta) contributes greatly to fibrotic kidney disease. the activator protein-1 (ap-1) inhibitor curcumin, a polyphenolic compound derived from curcuma longa, has been shown to reduce collagen accumulation in experimental pulmonary fibrosis. here, we investigate curcumin's ability to modulate tgf-beta's profibrotic actions in vitro. | 2004 | 15200418 |
| quantitative determination of curcuminoids in curcuma rhizomes and rapid differentiation of curcuma domestica val. and curcuma xanthorrhiza roxb. by capillary electrophoresis. | the three major curcuminoids, curcumin, demethoxycurcumin and bis-demethoxycurcumin, from curcuma domestica val. (curcuma longa l.) and curcuma xanthorrhiza roxb. (zingiberaceae) were fully separated and quantified in less than 5 min using a capillary zone electrophoresis method with standard fused-silica capillaries and photodiode array detection. an electrolyte solution of 20 mm phosphate, 50 mm sodium hydroxide and 14 mm beta-cyclodextrin was found to be appropriate. quantification was perfor ... | 2016 | 15202598 |
| ectopic expression of bcl-xl or ku70 protects human colon cancer cells (sw480) against curcumin-induced apoptosis while their down-regulation potentiates it. | curcumin, the yellow pigment derived from curcuma longa, is known to induce apoptosis of several cancer cells. however, many cancer cells protect themselves by over-expressing antiapoptotic proteins such as bcl-xl or ku70. to study their role in curcumin-induced apoptosis, human colon cancer cells (sw480) were made to over-express or under-express bcl-xl (by stable transfection) and ku70 (by transient transfection) using plasmid constructs that express their genes in sense or antisense orientati ... | 2004 | 15205359 |
| inhibitory activity of diarylheptanoids on farnesyl protein transferase. | diarylheptanoids [curcumin (1), demethoxycurcumin (2), bisdemethoxycurcumin (3), bisdimethoxymethylcurcumin (4), and 1,2-dihydrobis(de-o-methyl)curcumin (5)] were isolated from the methanolic extract of curcuma longa l. and a new cyclic diarylheptanoid (6) and a known compound 7 were isolated from fruits of alnus japonica steud. diarylheptanoids (1-3) inhibited farnesyl protein transferase (fptase) with an ic50 of 29-50 microm. the other compounds very mildly inhibited fptase, therefore, the inh ... | 2004 | 15214479 |
| in vitro and in vivo anti-tumoral effect of curcumin against melanoma cells. | curcumin, the active ingredient from the spice turmeric (curcuma longa linn), is known to be an anti-oxidant and an anti-inflammatory agent. it has been demonstrated recently to possess anti-angiogenic effects and pro-apoptotic activities against ehrlich ascites tumor cells. in the current study, curcumin was found to be cytotoxic in vitro for b16-r melanoma cells resistant to doxorubicin either cultivated as monolayers or grown in three-dimensional (3-d) cultures (spheroids). we have demonstrat ... | 2004 | 15221965 |
| indian food ingredients and cancer prevention - an experimental evaluation of anticarcinogenic effects of garlic in rat colon. | the major food items of indian cuisine include rice, wheat, diary products, and abundant fruits and vegetables. beside these, there are several kinds of herbs and spices as important ingredients, containing many phytochemicals with medicinal properties, adding taste to indian cuisine. an impressive body of data exists in support of the concept that indian food ingredients can be used in preventive strategies aimed at reducing the incidence and mortality of different types of cancers because of t ... | 2004 | 15244513 |
| interventions in aging and age-associated pathologies by means of nutritional approaches. | so-called antioxidant strategies have not been shown convincingly to be effective in increasing life spans of animals. thus, the general consensus of experimental gerontology in the last century was that the only reproducible means of prolonging survivals of animals is the calorie restriction paradigm. as a challenge against this dogma, we attempted to examine the effect of two potent antioxidants, one tetrahydrocurcumin (a biotransformed metabolite of curcumin contained in turmeric of indian cu ... | 2004 | 15247057 |
| curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/apo2l by inhibiting nuclear factor-kappab through suppression of ikappabalpha phosphorylation. | epidemiologic studies suggest that diet rich in plant-derived foods plays an important role in the prevention of prostate cancer. curcumin, the yellow pigment in the spice turmeric, has been shown to exhibit chemopreventive and growth inhibitory activities against multiple tumor cell lines. we have shown previously that curcumin and tumor necrosis factor-related apoptosis-inducing ligand (trail)/apo2l interact to induce cytotoxicity in the lncap prostate cancer cell line. in this study, we inves ... | 2004 | 15252141 |
| induction of apoptosis by ar-turmerone on various cell lines. | this study investigated the cytotoxic effect of ar-turmerone isolated from turmeric (curcuma longa l) on the k562, l1210, u937 and rbl-2h3 cell lines by the mtt assay. ar-turmerone exhibited potent cytotoxicity on these cancer cell lines. the ic50 values of ar-turmerone on these cell lines were 20-50 microg/ml. they showed an increased inhibition ratio on cell viability according to the drug concentration < or = 80 microg/ml in the cell lines tested. the dna fragmentation that is a characteristi ... | 2004 | 15254774 |
| curcumin induces c-jun n-terminal kinase-dependent apoptosis in hct116 human colon cancer cells. | curcumin, the major pigment of the dietary spice turmeric has the potential for chemoprevention by promotion of apoptosis. mitogen-activated protein kinase (mapk) and nf-kappa b (nfkappab) signalling cascades are thought to regulate apoptosis and cell survival. while curcumin inhibits nfkappab, its effects upon the mapk pathways are unclear. this study investigates curcumin effects upon mapk signalling and apoptosis in hct116 cells. here we report that curcumin time- and dose-dependent induction ... | 2004 | 15256484 |
| antioxidant effect of curcumin in selenium induced cataract of wistar rats. | wistar rat pups treated with curcumin, a natural constituent of curcuma longa before being administered with selenium showed no opacities in the lens. the lipid peroxidation, xanthine oxidase enzyme levels in the lenses of curcumin and selenium co-treated animals were significantly less when compared to selenium treated animals. the superoxidase dismutase and catalase enzyme activities of curcumin and selenium co-treated animal lenses showed an enhancement. curcumin co-treatment seems to prevent ... | 2004 | 15260112 |
| early human safety study of turmeric oil (curcuma longa oil) administered orally in healthy volunteers. | turmeric extract and turmeric oil have shown chemoprotective effect against chemically-induced malignancies in experimental animals. they can reverse precancerous changes in oral submucous fibrosis in humans. the use of turmeric or curcuma longa linn as a spice and household remedy has been known to be safe for centuries. in view of the long term administration required for cancer prevention a phase i clinical trial of turmeric oil (to) was designed to study the safety and tolerance of to in vol ... | 2003 | 15260388 |
| mining medline for implicit links between dietary substances and diseases. | text mining systems aim at knowledge discovery from text collections. this work presents our text mining algorithm and demonstrates its use to uncover information that could form the basis of new hypotheses. in particular, we use it to discover novel uses for curcuma longa, a dietary substance, which is highly regarded for its therapeutic properties in asia. | 2004 | 15262811 |
| protective effects of curcuma longa on ischemia-reperfusion induced myocardial injuries and their mechanisms. | the present study was undertaken to evaluate the cardioprotective potential of curcuma longa (turmeric) in the ischemia-reperfusion (i/r) model of myocardial infarction (mi). wistar rats were divided into three groups and received saline orally (sham, control i/r group) and curcuma longa 100 mg/kg (cl-100 treated group) respectively for one month. on the 31st day, rats of the control i/r and cl treated groups were subjected to 45 min of occlusion of the lad coronary artery and were thereafter re ... | 2004 | 15268970 |
| evidence against the rescue of defective deltaf508-cftr cellular processing by curcumin in cell culture and mouse models. | curcumin, the yellow colored component of the spice turmeric, has been reported to rescue defective deltaf508-cystic fibrosis transmembrane conductance regulator (cftr) cellular processing in homozygous mutant mice, restoring nasal potential differences and improving survival (egan, m. e., pearson, m., weiner, s. a., rajendran, v., rubin, d., glockner-pagel, j., canny, s., du, k., lukacs, g. l., and caplan, m. j. (2004) science 304, 600-602). because of the implied potential use of curcumin or s ... | 2004 | 15280357 |
| curcumin damages dna in human gastric mucosa cells and lymphocytes. | the naturally occurring pigment curcumin, a major component of the spice turmeric, is reported to be a potent inhibitor of the initiation and promotion of many cancers. due to its presence in the diet, one of its primary targets is the human gastric mucosa (gm) cells. using the sensitive single cell electrophoresis method (comet assay), we found that curcumin at of 15, 25, and 50 microm caused dna damage in gm cells and human peripheral blood lymphocytes. there was no difference between the exte ... | 1999 | 15281237 |
| sulfur free radical reactivity with curcumin as reference for evaluating antioxidant properties of medicinal zingiberales. | rhizome extracts of some members of the medicinal zingiberales are widely used in dietary intake as well as in the traditional system of medicine. curcumin, the chrome orange-yellow coloring compound present in turmeric rhizomes, has long been known to possess antioxidant property. crude methanol extracts of the rhizomes of 11 species--alpinia allughas, a. galanga, curcuma amada, c. caesia, c. leucorrhiza, hedychium coronarium, h. coccineum, h. flavescens, kaempferia galanga, zingiber cassumunar ... | 2004 | 15312045 |
| curcumin interaction with copper and iron suggests one possible mechanism of action in alzheimer's disease animal models. | curcumin is a polyphenolic diketone from turmeric. because of its anti-oxidant and anti-inflammatory effects, it was tested in animal models of alzheimer's disease, reducing levels of amyloid and oxidized proteins and preventing cognitive deficits. an alternative mechanism of these effects is metal chelation, which may reduce amyloid aggregation or oxidative neurotoxicity. metals can induce abeta aggregation and toxicity, and are concentrated in ad brain. chelators desferrioxamine and clioquinol ... | 2004 | 15345806 |
| a water extract of curcuma longa l. (zingiberaceae) rescues pc12 cell death caused by pyrogallol or hypoxia/reoxygenation and attenuates hydrogen peroxide induced injury in pc12 cells. | a number of studies indicate that free radicals are involved in the neurodegeneration in alzheimer's disease (ad). the role of superoxide anion (o2*-) in neuronal cell injury induced by reactive oxygen species (ros) was examined in pc12 cells using pyrogallol (1,2,3-benzenetrior), a donor to release o2*-. pyrogallol induced pc12 cell death at concentrations, which evidently increased intracellular o2*-, as assessed by o2*- sensitive fluorescent precursor hydroethidine (het). a water extract of c ... | 2004 | 15350833 |
| comparative effects of curcumin and an analog of curcumin on alcohol and pufa induced oxidative stress. | alcoholic liver disease is a major medical complication of alcohol abuse and a common liver disease in western countries. increasing evidence demonstrates that oxidative stress plays an important etiologic role in the development of alcoholic liver disease. alcohol alone or in combination with high fat is known to cause oxidative injury. the present study therefore aims at evaluating the protective role of curcumin, an active principle of turmeric and a synthetic analog of curcumin (ca) on alcoh ... | 2004 | 15367386 |
| effect of curcumin on normal and tumor cells: role of glutathione and bcl-2. | curcumin, a well-known dietary pigment derived from curcuma longa, inhibited growth of several types of malignant cells both in vivo and in vitro. however, its mechanism of action still remains unclear. in this study, we have focused primarily on the cytotoxic effects of curcumin on three human tumor cell lines and rat primary hepatocytes. curcumin induced apoptosis in mcf-7, mdamb, and hepg2 cells in a dose-dependent and time-dependent manner. apoptosis was mediated through the generation of re ... | 2004 | 15367704 |
| curcumin, a novel p300/creb-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. | acetylation of histones and non-histone proteins is an important post-translational modification involved in the regulation of gene expression in eukaryotes and all viral dna that integrates into the human genome (e.g. the human immunodeficiency virus). dysfunction of histone acetyltransferases (hats) is often associated with the manifestation of several diseases. in this respect, hats are the new potential targets for the design of therapeutics. in this study, we report that curcumin (diferuloy ... | 2004 | 15383533 |
| evaluation of dna damage in mice topically exposed to total particulate matter from mainstream and sidestream smoke from cigarettes and bidis. | the genotoxic potential of total particulate matter (tpm) from mainstream smoke (ms) and sidestream smoke (ss) of indian smoking products, namely cigarettes and bidis, as well as a brand of us cigarettes, was studied by determining the levels of bulky aromatic dna adducts in mouse tissues. tpm from ms or ss of various smoking products [equal weights (2.5 mg) or the amount derived from equal (0.25) cigarette/bidi] was applied topically to mouse skin once a day for four consecutive days and adduct ... | 2004 | 15388816 |
| turmeric, haldi or haridra, in eye disease. | 1950 | 15409637 | |
| some like it hot: curcumin and cftr. | the activation of mutant forms of the cystic fibrosis transmembrane conductance regulator (cftr), particularly the most frequent mutant allele (deltaf508), is a potential strategy for the treatment of the disease cystic fibrosis (cf). therefore, it is of great interest that curcumin, a component of the spice turmeric, is reported to restore function to this allele, both in heterologous expression systems and in deltaf508 cf mice. although other laboratories have not been able to confirm the init ... | 2004 | 15464445 |
| prooxidant activity of curcumin: copper-dependent formation of 8-hydroxy-2'-deoxyguanosine in dna and induction of apoptotic cell death. | curcumin, a well-known antioxidant in a principal ingredient of turmeric, acted as a prooxidant causing a copper-dependent dna damage and the induction of apoptosis. treatment of dna from plasmid pbr322 and calf thymus with curcumin plus copper ion caused strand scission and the formation of 8-hydroxy-2(')-deoxyguanosine in dna. addition of catalase protected dna from the curcumin-dependent injuries, indicating that hydroxyl radical may participate in the dna damage. flow cytometry analysis show ... | 2004 | 15465643 |
| biochemical mechanism of modulation of human p-glycoprotein (abcb1) by curcumin i, ii, and iii purified from turmeric powder. | p-glycoprotein (pgp, abcb1) is an atp-dependent drug efflux pump linked to development of multidrug resistance (mdr) in cancer cells. previously [biochem pharmacol 2002;64:573-82], we reported that a curcumin mixture could modulate both function and expression of pgp. this study focuses on the effect of three major curcuminoids--curcumin i, ii and iii purified from a curcumin mixture--on modulation of pgp function in a multidrug resistant human cervical carcinoma cell line (kb-v1). the similar i ... | 2004 | 15476675 |
| antimicrobial activity of ultrasound-assisted solvent-extracted spices. | the objective of this research was to determine the antimicrobial activity of conventional and high-intensity ultrasound-assisted (hi-us) solvent-extracted thai spices, including ginger (zingiber officinale rose), fingerroot (bosenbergia pandurata holtt) and turmeric (curouma longa linn). | 2004 | 15482429 |
| activation of ppar{gamma} by curcumin inhibits moser cell growth and mediates suppression of gene expression of cyclin d1 and egfr. | colorectal cancer is a leading cause of cancer-related morbidity and mortality in the united states. curcumin, the yellow pigment in turmeric, possesses inhibitory effects on growth of a variety of tumor cells by reducing cell proliferation and inducing apoptosis. effects of the peroxisome proliferator-activated receptor-gamma (ppargamma) on stimulating cell differentiation and on inducing cell cycle arrest have attracted attention from the perspective of treatment and prevention of cancer. the ... | 2005 | 15486348 |
| constitutive activation of transcription factor ap-1 in cervical cancer and suppression of human papillomavirus (hpv) transcription and ap-1 activity in hela cells by curcumin. | the transcription factor ap-1 plays a central role in the transcriptional regulation of specific types of high-risk human papillomaviruses (hpvs) such as hpv16 and hpv18, which are etiologically associated with the development of cancer of the uterine cervix in women. in our study, we investigated the ap-1 binding activity and the expression pattern of different members of the ap-1 transcription factor family (c-jun, junb, jund, c-fos, fosb, fra-1 and fra-2) in different grades of cervical lesio ... | 2005 | 15514944 |
| antihyperglycaemic and antioxidant effect of hyponidd, an ayurvedic herbomineral formulation in streptozotocin-induced diabetic rats. | hyponidd is a herbomineral formulation composed of the extracts of ten medicinal plants ( momordica charantia, melia azadirachta, pterocarpus marsupium, tinospora cordifolia , gymnema sylvestre, enicostemma littorale, emblica officinalis, eugenia jambolana, cassia auriculata and curcuma longa). we have investigated hyponidd for its possible antihyperglycaemic and antioxidant effect in diabetic rats. rats were rendered diabetic by streptozotocin (stz) (45 mg kg(-1) body weight). oral administrati ... | 2004 | 15525451 |
| antioxidant availability of turmeric in relation to its medicinal and culinary uses. | turmeric (curcuma longa) has been used in indian cooking, and in herbal remedies. its possible mechanism of action was examined in terms of antioxidant availability during actual cooking conditions and in therapeutic applications using standardized extracts. the assays involve different levels of antioxidant action such as oxygen radical absorbance capacity (orac), radical scavenging abilities using 1,1-diphenyl-2-picryl hydrazyl (dpph), 2,2'-azobis-3-ethylbenzthiazoline-6-sulfonic acid (abts), ... | 2004 | 15551376 |
| curcumin, the active constituent of turmeric, inhibits amyloid peptide-induced cytochemokine gene expression and ccr5-mediated chemotaxis of thp-1 monocytes by modulating early growth response-1 transcription factor. | epidemiological studies show reduced risk of alzheimer's disease (ad) among patients using non-steroidal inflammatory drugs (nsaid) indicating the role of inflammation in ad. studies have shown a chronic cns inflammatory response associated with increased accumulation of amyloid peptide and activated microglia in ad. our previous studies showed that interaction of abeta1-40 or fibrilar abeta1-42 caused activation of nuclear transcription factor, early growth response-1 (egr-1), which resulted in ... | 2004 | 15569263 |
| botanical medicine and cancer: a review of the safety and efficacy. | it is currently estimated that > 50% of all patients diagnosed with cancer explore complementary and alternative medicine - especially herbal medicine. we conducted a comprehensive review to assess the safety and efficacy of herbal medicines commonly used by patients in an attempt to: prevent cancer; treat cancer; and treat adverse effects associated with conventional cancer treatments. current evidence suggests that asian ginseng, garlic, green tea, tomatoes and soy intake as part of the diet m ... | 2004 | 15571467 |
| [study on the sfe condition for curcumin in curcuma longa]. | to optimize the conditions of supercritical fluid extraction (sfe) for curcumin in curcuma longa. | 2004 | 15575202 |
| curcumin for malaria therapy. | malaria remains a major global health concern. new, inexpensive, and effective antimalarial agents are urgently needed. here we show that curcumin, a polyphenolic organic molecule derived from turmeric, inhibits chloroquine-resistant plasmodium falciparum growth in culture in a dose dependent manner with an ic(50) of approximately 5 microm. additionally, oral administration of curcumin to mice infected with malaria parasite (plasmodium berghei) reduces blood parasitemia by 80-90% and enhances th ... | 2005 | 15582601 |
| effects of dietary quillaja saponin and curcumin on the performance and immune status of weaned piglets. | the objective of this study was to determine whether dietary quillaja saponin and curcumin (extract of turmeric) can modify piglet immune status and performance immediately after weaning. piglets (n = 192) were weaned at 29 +/- 0.1 d and allocated to treatment (six replicates of eight pig per treatment) accounting for weight, litter, and gender, using a 2 x 2 factorial arrangement. factors were diets with or without (as-fed basis) quillaja saponin (750 mg/kg during wk 1, 300 mg/kg during wk 2 to ... | 2005 | 15583046 |
| correction of the cf defect by curcumin: hypes and disappointments. | cystic fibrosis (cf), the most-common lethal hereditary disease in the white population, is caused by mutations in the cystic fibrosis transmembrane conductance regulator (cftr) gene. the mutation that is most frequently responsible for the disease, deltaf508, causes misfolding and retention of the cftr protein in the endoplasmic reticulum. this leads to a series of cellular dysfunctions and results in a multi-organ disease. in a recent report, egan et al.(1) demonstrated that curcumin, a non-to ... | 2005 | 15612029 |
| curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer. | matrix metalloproteinases (mmps) are suggested to play a critical role in extracellular matrix degradation and remodeling during inflammation and wound healing processes. however, the role of mmps in indomethacin-induced gastric ulcer and its healing process are not clearly understood. this study is aimed at determining the regulation of mmp-9 and -2 activities in indomethacin-induced acute gastric ulceration and healing. indomethacin-ulcerated stomach extracts exhibit significant up-regulation ... | 2004 | 15615723 |
| a novel formulation design about water-insoluble oily drug: preparation of zedoary turmeric oil microspheres with self-emulsifying ability and evaluation in rabbits. | to enhance in vivo absorption of zedoary turmeric oil (zto) and develop new formulations of a water-insoluble oily drug, novel zto microspheres with self-emulsifying ability, called self-emulsifying microspheres here, were prepared in a liquid system by the quasi-emulsion solvent diffusion method. the microspheres containing hydroxypropyl methylcellulose acetate succinate (hpmcas-lg), talc and aerosil 200 formed the stable surfactant-free emulsion when exposed to the ph 6.8 phosphate buffer, and ... | 2004 | 15620872 |
| hepatoprotective effect of sesquiterpenes in turmeric. | hepatoprotective effect of turmeric together with its sesquiterpenes and curcuminoids fractions were examined on d-galactosamine induced liver injury in rats. all the diets individually contained the turmeric extract, the curcuminoids fraction, and the sesquiterpenes fraction suppressed the increase of ldh, alt, and ast levels caused by d-galn treatment. since few anti-oxidative activities are expected in the sesquiterpenes fraction, it is presumed that hepatoprotective mechanism of sesquiterpen ... | 2004 | 15630192 |
| curcumin influences hepatic expression patterns of matrix metalloproteinases in liver toxicity. | hepatic fibrosis is a result of an imbalance between enhanced matrix synthesis and diminished breakdown of connective tissue proteins, the net result of which is increased deposition of extra cellular matrix. in this concept matrix metalloproteinases play an important role because their activity is largely responsible for extra cellular matrix breakdown. in the present study we have tested the influence of curcumin, the active principle of turmeric, on matrix metalloproteinase expression during ... | 2004 | 15646009 |
| effects of dietary chemopreventive phytochemicals on p-glycoprotein function. | the effects of dietary phytochemicals on p-glycoprotein function were investigated using human multidrug-resistant carcinoma kb-c2 cells and the fluorescent p-glycoprotein substrates daunorubicin and rhodamine 123. the effects of natural chemopreventive compounds, capsaicin found in chilli peppers, curcumin in turmeric, [6]-gingerol in ginger, resveratrol in grapes, sulforaphane in broccoli, 6-methylsulfinyl hexyl isothiocyanate (6-hitc) in japanese horseradish wasabi, indole-3-carbinol (i3c) in ... | 2005 | 15649425 |
| curcumin induces glutathione biosynthesis and inhibits nf-kappab activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity. | oxidants and tumor necrosis factor-alpha (tnf-alpha) activate transcription factors such as nuclear factor-kappab (nf-kappab), which is involved in the transcription of proinflammatory mediators, including interleukin-8 (il-8). curcumin (diferuloylmethane) is a naturally occurring flavonoid present in the spice turmeric, which has a long traditional use as a chemotherapeutic agent for many diseases. we hypothesize that curcumin may possess both antioxidant and antiinflammatory properties by incr ... | 2013 | 15650394 |
| suppression of the nuclear factor-kappab activation pathway by spice-derived phytochemicals: reasoning for seasoning. | the activation of nuclear transcription factor kappab has now been linked with a variety of inflammatory diseases, including cancer, atherosclerosis, myocardial infarction, diabetes, allergy, asthma, arthritis, crohn's disease, multiple sclerosis, alzheimer's disease, osteoporosis, psoriasis, septic shock, and aids. extensive research in the last few years has shown that the pathway that activates this transcription factor can be interrupted by phytochemicals derived from spices such as turmeric ... | 2004 | 15659827 |
| human colon cancer cells lacking bax resist curcumin-induced apoptosis and bax requirement is dispensable with ectopic expression of smac or downregulation of bcl-xl. | multiple apoptotic stimuli induce conformational changes in bax, a proapoptotic protein from the bcl-2 family and its deficiency is a frequent cause of chemoresistance in colon adenocarcinomas. curcumin, a dietary compound from turmeric, is known to induce apoptosis in a variety of cancer cells. to understand the role of bax in curcumin-induced apoptosis we used hct116 human colon cancer cells with one allele of bax gene (bax+/-) and bax knockout hct116 (bax-/-) cells in which bax gene is inacti ... | 2005 | 15661804 |
| screening of antioxidants from medicinal plants for cardioprotective effect against doxorubicin toxicity. | doxorubicin is an important and effective anticancer drug widely used for the treatment of various types of cancer but its clinical use is limited by dose-dependent cardiotoxicity. elevated tissue levels of cellular superoxide anion/oxidative stress are a mechanism by which doxorubicin-induced cardiotoxicity. selected medicinal plant extracts were tested for their antioxidant capacity and cardioprotective effect against doxorubicin-induced cardiotoxicity. the cardiac myoblasts h9c2 were incubate ... | 2005 | 15667600 |
| consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences. | curcumin, a constituent of the spice turmeric, has been shown to reduce the adenoma burden in rodent models of colorectal cancer accompanied by a reduction of levels of the oxidative dna adduct 3-(2-deoxy-beta-di-erythro-pentafuranosyl)-pyr[1,2-alpha]-purin-10(3h)one (m(1)g) and of expression of the enzyme cyclooxygenase-2 (cox-2). we tested the hypothesis that pharmacologically active levels of curcumin can be achieved in the colorectum of humans as measured by effects on levels of m(1)g and co ... | 2005 | 15668484 |