Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| curcumin inhibits tyrosine kinase activity of p185neu and also depletes p185neu. | curcumin, a natural compound present in turmeric, possessing both anti-inflammatory and antioxidant effects, has been studied vigorously as a chemopreventative in several cancer models. the erbb2/neu gene-encoded p185neu tyrosine kinase is a potent oncoprotein. overexpression of p185neu in breast cancer is known to be a poor prognostic factor. we investigated the effect of curcumin on p185neu tyrosine kinase and on the growth of breast cancer cell lines. curcumin dose-dependently inhibited p185n ... | 1999 | 10430096 |
| curcumin mediated apoptosis in ak-5 tumor cells involves the production of reactive oxygen intermediates. | curcumin, the active ingredient of the rhizome of curcuma longa has anti-inflammatory, antioxidant and antiproliferative activities. although its precise mode of action remains elusive, studies have shown that chemopreventive action of curcumin might be due to its ability to induce apoptosis in cancer cells. curcumin was shown to be responsible for the inhibition of ak-5 tumor (a rat histiocytoma) growth by inducing apoptosis in ak-5 tumor cells via caspase activation. this study was designed to ... | 1999 | 10456330 |
| inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and ca2+ signaling. | curcumin, a dietary spice from turmeric, is known to be anti-inflammatory, anticarcinogenic, and antithrombotic. here, we studied the mechanism of the antiplatelet action of curcumin. we show that curcumin inhibited platelet aggregation mediated by the platelet agonists epinephrine (200 microm), adp (4 microm), platelet-activating factor (paf; 800 nm), collagen (20 microg/ml), and arachidonic acid (aa: 0.75 mm). curcumin preferentially inhibited paf- and aa-induced aggregation (ic50; 25-20 micro ... | 1999 | 10484074 |
| [the effect of chelidonium- and turmeric root extract on upper abdominal pain due to functional disorders of the biliary system. results from a placebo-controlled double-blind study]. | right upper abdominal pain may often be caused by biliary dyskinesia. choleretica and cholekinetica are widely used for medical treatment of complaints due to biliary dyskinesia despite of a lack of randomized clinical trials which may prove their efficacy and potency. | 1999 | 10495621 |
| curcumin inhibits th1 cytokine profile in cd4+ t cells by suppressing interleukin-12 production in macrophages. | 1 interleukin-12 (il-12) plays a central role in the immune system by driving the immune response towards t helper 1 (th1) type responses which are characterized by high ifn-gamma and low il-4 production. in this study we investigated the effects of curcumin, a natural product of plants obtained from curcuma longa (turmeric), on il-12 production by mouse splenic macrophages and the subsequent ability of these cells to regulate cytokine production by cd4+ t cells. 2 pretreatment with curcumin sig ... | 1999 | 10510448 |
| the effect of curcumin on glutathione-linked enzymes in k562 human leukemia cells. | curcumin, an antioxidant present in the spice turmeric (curcuma longa), has been shown to inhibit chemical carcinogenesis in animal models and has been shown to be an anti-inflammatory agent. while mechanisms of its biological activities are not understood, previous studies have shown that it modulates glutathione (gsh)-linked detoxification mechanisms in rats. in the present studies, we have examined the effects of curcumin on gsh-linked enzymes in k562 human leukemia cells. one micromolar curc ... | 1999 | 10514034 |
| anti-tumor promoting potential of naturally occurring diarylheptanoids structurally related to curcumin. | in recent years, there have been considerable efforts to search for naturally occurring substances for intervention of carcinogenesis. many components from medicinal or dietary plants have been identified to possess potential chemopreventive properties. for instance, curcumin, a yellow colouring agent from turmeric (curcuma longa linn., zingiberaceae) has been shown to inhibit tumor formation in diverse animal models. alpinia oxyphylla miquel that also belongs to ginger family has been used in o ... | 1999 | 10517978 |
| molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances. | recently, considerable attention has been focused on identifying naturally occurring chemopreventive substances capable of inhibiting, retarding, or reversing the multi-stage carcinogenesis. a wide array of phenolic substances, particularly those present in dietary and medicinal plants, have been reported to possess substantial anticarcinogenic and antimutagenic activities. the majority of these naturally occurring phenolics retain antioxidative and anti-inflammatory properties which appear to c ... | 1999 | 10518003 |
| neuroprotective role of curcumin from curcuma longa on ethanol-induced brain damage. | in the present study, curcumin from curcuma longa was screened for neuroprotective activity using ethanol as a model of brain injury. oral administration of curcumin to rats caused a significant reversal in lipid peroxidation, brain lipids and produced enhancement of glutathione, a non-enzymic antioxidant in ethanol intoxicated rats, revealing that the antioxidative and hypolipidaemic action of curcumin is-responsible for its protective role against ethanol induced brain injury. | 1999 | 10548748 |
| antibacterial activity of turmeric oil: a byproduct from curcumin manufacture. | curcumin, the yellow color pigment of turmeric, is produced industrially from turmeric oleoresin. the mother liquor after isolation of curcumin from oleoresin contains approximately 40% oil. the oil was extracted from the mother liquor using hexane at 60 degrees c, and the hexane extract was separated into three fractions using silica gel column chromatography. these fractions were tested for antibacterial activity by pour plate method against bacillus cereus, bacillus coagulans, bacillus subtil ... | 1999 | 10552805 |
| inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of nf-kappab activation via the nik/ikk signalling complex. | colorectal cancer is a major cause of cancer deaths in western countries, but epidemiological data suggest that dietary modification might reduce these by as much as 90%. cyclo-oxygenase 2 (cox2), an inducible isoform of prostaglandin h synthase, which mediates prostaglandin synthesis during inflammation, and which is selectively overexpressed in colon tumours, is thought to play an important role in colon carcinogenesis. curcumin, a constituent of turmeric, possesses potent anti-inflammatory ac ... | 1999 | 10557090 |
| oral administration of a turmeric extract inhibits ldl oxidation and has hypocholesterolemic effects in rabbits with experimental atherosclerosis. | the oxidation of low-density lipoproteins (ldl) plays an important role in the development of atherosclerosis. curcumin is a yellow pigment obtained from rhizomes of curcuma longa and is commonly used as a spice and food colouring. curcumin and turmeric extracts have several pharmacological effects including antitumour, anti-inflammatory, antioxidant and antiinfectious activities although the precise mechanisms involved remain to be elicited. we evaluated the effect of an ethanol-aqueous extract ... | 1999 | 10559523 |
| knowledge of consumers regarding the nature and extent of adulteration of indian foods. | the present study was carried out on 60 women consumers selected from three different localities of hisar city in india to study their knowledge regarding adulteration and detecting adulterants in commonly used food items. the post exposure correct responses of the respondents increased remarkably as 100.0 percent of the respondents gave correct responses regarding statements on adulteration of spices and condiments, the most common adulterated food item and to when and whom they could approach ... | 1999 | 10561864 |
| curcumin enhances wound healing in streptozotocin induced diabetic rats and genetically diabetic mice. | tissue repair and wound healing are complex processes that involve inflammation, granulation and tissue remodeling. interactions of different cells, extracellular matrix proteins and their receptors are involved in wound healing, and are mediated by cytokines and growth factors. previous studies from our laboratory have shown that curcumin (diferuloylmethane), a natural product obtained from the rhizomes of curcuma longa, enhanced cutaneous wound healing in rats and guinea pigs. in this study, w ... | 1999 | 10564565 |
| immunomodulatory activity of curcumin. | curcumin, an active ingredient present in curcuma longa, was analysed for the immunomodulatory activity in balb/c mice. curcumin administration was found to increase the total wrc count (15,290) significantly on the 12th day group of animals treated with vehicle alone showed results similar to that of normal animal (10,130 on 12th day). curcumin increased the circulating antibody titre (512) against srbc. curcumin administration increased the plaque forming cells (pfc) in the spleen and the maxi ... | 2013 | 10574627 |
| choleretic effects of curcuminoids on an acute cyclosporin-induced cholestasis in the rat. | former studies have shown that curcumin, which can be extracted from different curcuma species, is able to stimulate bile flow in rats, whereas bisdemethoxycurcumin, which is mainly found in rhizomes of curcuma longa, is believed to inhibit bile flow. to reevaluate this observation we investigated the influence of both curcuminoids on bile flow, bile acid concentration and excretion over a time period of 180 min in the bile fistula model in rats. furthermore, we tested the ability of both curcum ... | 1999 | 10575375 |
| curcuma longa inhibits tnf-alpha induced expression of adhesion molecules on human umbilical vein endothelial cells. | identification of non-steroidal anti-inflammatory small molecules is very important for the development of anti-inflammatory drugs. we demonstrate here that out of three compounds, viz diferuloylmethane, p-coumaroylferuloylmethane and di-p-coumaroylmethane, present in the ethyl acetate extract of curcuma longa, diferuloylmethane is most potent in inhibiting tnf-alpha induced expression of icam-1, vcam-1 and e-selectin on human umbilical vein endothelial cells. the inhibition by diferuloylmethane ... | 1999 | 10576620 |
| effects of marinating with asian marinades or western barbecue sauce on phip and meiqx formation in barbecued beef. | heterocyclic aromatic amines (haas), a group of chemicals formed during high-temperature cooking of meat and fish, are potent mutagens and are suspected to play a role in colorectal cancer. a recent study suggested that marinating meat may offer a way to reduce haa formation. hawaii's diverse ethnic populations, which are at various risks of colorectal cancer, often use traditional marinades when cooking meat. we compared the haa content of beef steaks marinated overnight with teriyaki sauce, tu ... | 1999 | 10578481 |
| potential role of cerebral glutathione in the maintenance of blood-brain barrier integrity in rat. | using the model of glutathione (gsh) depletion, possible role of gsh in the maintenance of blood-brain barrier (bbb) integrity was evaluated in rats. administration (i.p.) of gsh depletors, diethyl maleate (dem, 1-4 mmol/kg), phorone (2-3 mmol/kg) and 2-cyclohexene-1-one (chx, 1 mmol/kg), to male adults was found to deplete brain and liver gsh and increase the bbb permeability to micromolecular tracers (sodium fluorescein and [14c]sucrose) in a dose-dependent manner at 2h. however, bbb permeabil ... | 1999 | 10591399 |
| interaction of curcumin with phosphatidylcholine: a spectrofluorometric study. | curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3, 5-dione], the main constituent of the rhizomes of the plant curcume longa l. (turmeric), is a powerful antioxidant in both enzymatic and nonenzymatic systems. the interactions of curcumin with egg and soy phosphatidylcholine were followed by fluorescence spectroscopy. curcumin had very weak fluorescence in aqueous system, which was enhanced in apolar environments. curcumin emitted at 490 nm after being excited at 451 nm in phosphatid ... | 1999 | 10606563 |
| a dose dependent anti-genotoxic effect of turmeric. | the anti-genotoxic action of turmeric was evaluated by somatic mutation and recombination test (smart). as described in other mutagenecity tests, turmeric showed non mutagenic effects in the smart. the well known powerful mutagen urethane was used as a model to evaluate the anti-genotoxicity of turmeric. combined treatment of urethane and turmeric displayed, throughout all concentrations assayed, an inhibition of the genotoxic effect of urethane by turmeric. this anti-genotoxic effect was propor ... | 1999 | 10613194 |
| ferula asa-foetida and curcuma longa in traditional medical treatment and diet in nepal. | food and eating have powerful symbolic value among the hinduistically-influenced ethnic groups of nepal. in addition, food plays a major role in the concepts of illness and curing and constitute an integral part of traditional medical prescriptions. materials that are consumed in 0.5-1.5 g amounts in the daily diet (e.g. the spices turmeric and asafoetida) are used in minute amounts for medical purposes. why? three hypotheses are offered here to discuss this issue. | 1999 | 10616954 |
| antioxidative effects of turmeric, rosemary and capsicum extracts on membrane phospholipid peroxidation and liver lipid metabolism in mice. | phospholipid hydroperoxides (plooh) in the plasma, red blood cells (rbc) and liver of mice were measured after dietary supplementation for one week (1% w/w of diet) with a turmeric extract (curcuminoid), hexane extract of rosemary, and supercritical co2-extracted capsicum pigment (supplemented with alpha-tocopherol to prevent fading). a lower plooh level was found in rbc of the spice extract-fed mice (65-74% of the non-supplemented control mice). the liver lipid peroxidizability induced with fe2 ... | 1999 | 10664844 |
| [optimal high-yield agronomic measures for curcuma longa l]. | regression method of orthogonal conic substitution with factors was employed to build up a tuber yield simulation model. three main measures (sowing time, plant population, application rate of fertilizer) affecting the tuber yield were analyzed by the mathematical model of three unknown second order orthogonal rotative regression. the optimal agronomic measures were obtained. the results indicate that sowing time and plant population play a important role in raising the tuber yield. sowing time ... | 1997 | 10743182 |
| [effect of cultivating measures on the tuber yield of curcuma longa l]. | the effect of cultivating measures on the tuber yield of curcuma longa was observed. dibble planting has been proved move effective in raising the tuber yield than drill culture, and the dibble planting quantity has no effect on the tuber. the rational producing area, soil, seed tuber and so on were selected according to the experiments. | 1997 | 10743196 |
| l-929 cells harboring ectopically expressed rela resist curcumin-induced apoptosis. | curcumin (diferuloyl methane), the yellow pigment in turmeric (curcuma longa), is a potent chemopreventive agent. curcumin induces apoptosis of several, but not all, cancer cells. many cancer cells protect themselves against apoptosis by activating nuclear factor-kappab (nf-kappab)/rel, a transcription factor that helps in cell survival. signal-induced activation of nf-kappab is known to be inhibited by curcumin. to understand the role of nf-kappab in curcumin-induced apoptosis, we stably transf ... | 2000 | 10747850 |
| berberine. | berberine is a plant alkaloid with a long history of medicinal use in both ayurvedic and chinese medicine. it is present in hydrastis canadensis (goldenseal), coptis chinensis (coptis or goldenthread), berberis aquifolium (oregon grape), berberis vulgaris (barberry), and berberis aristata (tree turmeric). the berberine alkaloid can be found in the roots, rhizomes, and stem bark of the plants. berberine extracts and decoctions have demonstrated significant antimicrobial activity against a variety ... | 2000 | 10767672 |
| spice extracts as dose-modifying factors in radiation inactivation of bacteria. | three spices, chili, black pepper, and turmeric, were tested for the effect of their aqueous extracts on the sensitivity of three bacteria, escherichia coli, bacillus megaterium, and bacillus pumilusspores, to gamma-radiation. it was found that the extracts of the three spices offered protection to these organisms against inactivation by gamma-radiation. these spice extracts were also tested for their protection of naked plasmid dna. radiation-induced degradation of plasmid puc18 dna was reduced ... | 2000 | 10775394 |
| curcumin is an in vivo inhibitor of angiogenesis. | curcumin is a small-molecular-weight compound that is isolated from the commonly used spice turmeric. in animal models, curcumin and its derivatives have been shown to inhibit the progression of chemically induced colon and skin cancers. the genetic changes in carcinogenesis in these organs involve different genes, but curcumin is effective in preventing carcinogenesis in both organs. a possible explanation for this finding is that curcumin may inhibit angiogenesis. | 1998 | 10780880 |
| an hydroalcoholic extract of curcuma longa lowers the abnormally high values of human-plasma fibrinogen. | 2000 | 10802125 | |
| dietary curcumin prevents ocular toxicity of naphthalene in rats. | administration of naphthalene is known to cause cataract formation in rats and rabbits and naphthalene-initiated cataract is frequently used as a model for studies on senile cataract in humans. oxidative stress has been implicated in the mechanism of naphthalene-induced cataract. curcumin, a constituent of turmeric, a spice used in indian curry dishes, is an effective antioxidant and is known to induce the enzymes of glutathione-linked detoxification pathways in rats. during the present studies, ... | 2000 | 10814889 |
| therapeutic potential of curcumin in human prostate cancer. ii. curcumin inhibits tyrosine kinase activity of epidermal growth factor receptor and depletes the protein. | in a search for alternative and preventive therapies for prostate cancer, attention was focused on the ways in which curcumin (turmeric), used in food and medicine in india for centuries, could interfere with the growth factor signaling pathways in both androgen-dependent and androgen-independent prostate cancer cells, as exemplified by the epidermal growth factor receptor (egf-r) signaling. | 2000 | 10851300 |
| a simple and efficient separation of the curcumins, the antiprotozoal constituents of curcuma longa. | a simple and efficient method for the separation of the three phenolic diketones, curcumin 1, demethoxycurcumin 2, and bis-demethoxycurcumin 3, isolated from the rhizomes of curcuma longa has been developed. the method is of general applicability for the separation of compounds containing acidic and chelating groups and is amenable to large scale separations. the curcumins 1-3 show moderate activity against plasmodium falciparum (ic50: 3.5, 4.2 and 3.0 micrograms/ml) and leishmania major (ic50: ... | 2000 | 10865470 |
| supercritical carbon dioxide extraction of turmeric (curcuma longa). | turmeric oil was extracted from turmeric (curcuma longa) with supercritical carbon dioxide in a semicontinuous-flow extractor. extraction rate was measured as a function of pressure, temperature, flow rate, and particle size. the extraction rate increased with an increase in co(2) flow rate and with a reduction of particle size. the effect of pressure and temperature on turmeric extraction suggested the use of higher pressure and lower temperature at which solvent density is greater and thus the ... | 2000 | 10888520 |
| potential interactions between alternative therapies and warfarin. | potential and documented interactions between alternative therapy agents and warfarin are discussed. an estimated one third of adults in the united states use alternative therapies, including herbs. a major safety concern is potential interactions of alternative medicine products with prescription medications. this issue is especially important with respect to drugs with narrow therapeutic indexes, such as warfarin. herbal products that may potentially increase the risk of bleeding or potentiate ... | 2000 | 10902065 |
| review on some plants of indian traditional medicine with antioxidant activity. | a lot of medicinal plants, traditionally used for thousands of years, are present in a group of herbal preparations of the indian traditional health care system (ayurveda) named rasayana proposed for their interesting antioxidant activities. among the medicinal plants used in ayurvedic rasayana for their therapeutic action, some of these have been throughly investigated. in the present paper seven plants (emblica officinalis l., curcuma longa l., mangifera indica l., momordica charantia l., sant ... | 2000 | 10904144 |
| turmeric. | 2000 | 10911509 | |
| effect of cinnamon, clove and some of their constituents on the na(+)-k(+)-atpase activity and alanine absorption in the rat jejunum. | the effect of a water extract of some spices on the in vitro activity of the rat jejunal na(+)-k(+)-atpase was investigated. extracts of nutmeg, cinnamon, clove, cumin, coriander, turmeric and caraway all inhibited the atpase, while anise seed and white pepper exerted no significant effects. the extracts of clove and cinnamon had the most potent inhibitory effect on the intestinal atpase as compared to extracts of other spices. they also inhibited the in vitro na(+)-k(+)-atpase activity in a cru ... | 2000 | 10930696 |
| current lead natural products for the chemotherapy of human immunodeficiency virus (hiv) infection. | a large variety of natural products have been described as anti-hiv agents, and for a portion thereof the target of interaction has been identified. cyanovirin-n, a 11-kda protein from cyanobacterium (blue-green alga) irreversibly inactivates hiv and also aborts cell-to-cell fusion and transmission of hiv, due to its high-affinity interaction with gp120. various sulfated polysaccharides extracted from seaweeds (i.e., nothogenia fastigiata, aghardhiella tenera) inhibit the virus adsorption proces ... | 2000 | 10934347 |
| antifungal potential of some higher plants against fusarium udum causing wilt disease of cajanus cajan. | the fungitoxic effects of different plant extracts on fusarium udum, which causes wilt disease of cajanus cajan in vitro and in vivo, were examined. the complete arrest of the radial growth of the pathogen occurred at a 10% concentration of leaf extract from adenocallyma alliaceum. a leaf extract of citrus medica, a root extract of asparagus adscendens, rhizome extracts of curcuma longa and zingiber officinale, and a bulb extract of allium sativum inhibited up to 100% growth at higher concentrat ... | 2000 | 10955831 |
| role of curcumin in idiopathic inflammatory orbital pseudotumours. | the present report, describes for the first time the clinical efficacy of curcumin, the active constituent of rhizomes of curcuma longa, in the treatment of patients suffering from idiopathic inflammatory orbital pseudotumours. curcumin was administered orally at a dose of 375 mg/3 times/day orally for a period of 6-22 months in eight patients. they were followed up for a period of 2 years at 3 monthly intervals. five patients completed the study, out of which four recovered completely and in on ... | 2000 | 10960899 |
| cytotoxicity, antioxidant and anti-inflammatory activities of curcumins i-iii from curcuma longa. | curcumin i, curcumin ii (monodemethoxycurcumin) and curcumin iii (bisdemethoxycurcumin) from curcuma longa were assayed for their cytotoxicity, antioxidant and anti-inflammatory activities. these compounds showed activity against leukemia, colon, cns, melanoma, renal, and breast cancer cell lines. the inhibition of liposome peroxidation by curcumins i-iii at 100 microg/ml were 58, 40 and 22%, respectively. the inhibition of cox-i and cox-ii enzymes by the curcumins was observed. curcumins i-iii ... | 2000 | 10969724 |
| curcumin-glutathione interactions and the role of human glutathione s-transferase p1-1. | curcumin (diferuloylmethane), a yellow pigment of turmeric with antioxidant properties has been shown to be a cancer preventative in animal studies. it contains two electrophilic alpha, beta-unsaturated carbonyl groups, which can react with nucleophilic compounds such as glutathione (gsh), but formation of the gsh-curcumin conjugates has not previously been demonstrated. in the present studies, we investigated the reactions of curcumin with gsh and the effect of recombinant human glutathione s-t ... | 2000 | 10996298 |
| chemopreventive effect of curcumin on n-nitrosomethylbenzylamine-induced esophageal carcinogenesis in rats. | modifying effects of curcumin (derived from the rhizome of curcuma longa l.) during the initiation or post-initiation phase of n-nitrosomethylbenzylamine (nmba)-induced esophageal carcinogenesis were investigated in male f344 rats. five-week-old rats were divided into 5 groups, and groups 1, 2 and 3 were given intraperitoneal injections of nmba (0.5 mg / kg body weight / injection 15 times) for 5 weeks from 7 weeks old to induce esophageal neoplasms. groups 2 and 3 were fed the diet containing 5 ... | 2000 | 11011116 |
| curcumin inhibits lipoxygenase by binding to its central cavity: theoretical and x-ray evidence. | many lipoxygenase inhibitors including curcumin are currently being studied for their anti-carcinogenic properties. curcumin is a naturally occurring polyphenolic phytochemical isolated from the powdered rhizome of the plant curcuma longa that possesses anti-inflammatory properties and inhibits cancer formation in mice. recently it was shown that the soybean lipoxygenase l1 catalyzed the oxygenation of curcumin and that curcumin can act as a lipoxygenase substrate. in the current study, we inves ... | 2000 | 11029517 |
| differential modulation of nitric oxide production by curcumin in host macrophages and nk cells. | curcumin, the yellow pigment from curcuma longa, has been shown to possess tumoricidal activity. we have earlier reported the induction of apoptosis in ak-5, rat histiocytic cells by curcumin leading to the inhibition of tumor growth in vivo. in this study we have observed differential activation status in host macrophages and nk cells induced by curcumin during the spontaneous regression of subcutaneously transplanted ak-5 tumors. closer scrutiny of the cytokine profile and nitric oxide (no) pr ... | 2000 | 11033360 |
| inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats. | curcumin (ccm), a major yellow pigment of turmeric obtained from powdered rhizomes of the plant curcuma longa linn, is commonly used as coloring agent in foods, drugs and cosmetics. in this study we report that gavage administration of 200 mg/kg or 600 mg/kg ccm effectively suppressed diethylnitrosamine (den)-induced liver inflammation and hyperplasia in rats, as evidenced by histopathological examination. immunoblotting analysis showed that ccm strongly inhibited den-mediated the increased expr ... | 2000 | 11038236 |
| [ontogeny of curcuma longa l]. | based on the research of growth of organs, accumulation of dry matter, distribution of photosynthetic production and displacement of growth centre, the growth of turmeric can be divided into three stages. there are 13 leaves in the life of turmeric. leaf formation takes place rapidly to form 8 leaves in the seedling stage. the leaf area and increase of dry matter per day in roots and leaves are smaller or lower in the seedling stage. in the daughter rhizome formation stage, nar reaches the maxim ... | 1997 | 11038924 |
| an hydroalcoholic extract of curcuma longa lowers the apo b/apo a ratio. implications for atherogenesis prevention. | it is generally accepted that free-radical induced blood lipid peroxidation and especially peroxidized ldl play a central role in the pathogenesis of atherosclerosis and related cardiovascular disease. moreover, recent research highlights the key contribution of apolipoprotein b (apo b) to atherogenesis as the main inductor of one of its earlier steps, i.e. macrophage proliferation. this has led us to investigate the apo b response to a very effective phenolic lipid-antioxidant, namely an hydroa ... | 2000 | 11040400 |
| inhibition of formation of oxidative volatile components in fermented cucumbers by ascorbic acid and turmeric. | two naturally occurring antioxidants, ascorbic acid and turmeric, were effective in inhibiting formation of hexanal, (e)-2-penenal, (e)-2-hexenal, (e)-2-heptenal, and (e)-2-octenal when slurries of fermented cucumber tissue were exposed to oxygen. added ascorbic acid prevented formation of most of these oxidative aldehydes at 175 ppm or greater. turmeric, which is used commercially as a yellow coloring in cucumber pickle products, was found to almost completely prevent aldehyde formation at 40 p ... | 2000 | 11052754 |
| preservation of alpha-tocopherol in sunflower oil by herbs and spices. | the ability of some commercially available herb and spice extracts to preserve alpha-tocopherol in sunflower oil during heating at 85-105 degrees c was assessed using sunflower oil as a model system. the rancimat was evaluated for the heating stage and was used throughout as it was shown to be viable: alpha-tocopherol did not evaporate under the test conditions. the delay in the onset of rancidity was found to be directly related to the initial alpha-tocopherol concentration (p < 0.01). rosemary ... | 2000 | 11103298 |
| occurrence of orally administered curcuminoid as glucuronide and glucuronide/sulfate conjugates in rat plasma. | curcuminoids, curcumin and its structurally related compounds, constitute the phenolic yellowish pigment of turmeric. we investigated the absorption and metabolism of orally administered curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) in rats. hplc and lc-ms analyses after enzymatic hydrolyses showed that the predominant metabolites in plasma following administration were glucuronides and glucuronide/sulfates (conjugates with both glucuronide and sulfate) of curcuminoids. the ... | 2000 | 11105995 |
| effect of solvent on the excited-state photophysical properties of curcumin. | photophysical properties of curcumin, 1,7-bis-(4-hydroxy-3-methoxy phenyl)-1,6-heptadiene-2,5-dione, a pigment found in the rhizomes of curcuma longa (turmeric) have been studied in different kinds of organic solvent and also in triton x-100 aqueous micellar media using time-resolved fluorescence and transient absorption techniques having pico and nanosecond time resolution, in addition to steady-state absorption and fluorescence spectroscopic techniques. steady-state absorption and fluorescence ... | 2000 | 11107847 |
| studies on the genotoxicity of turmeric extracts in bacterial system. | 2000 | 11118850 | |
| changes in the prostaglandin levels in alcohol toxicity: effect of curcumin and n-acetylcysteine. | the present study was undertaken to evaluate the potential role of curcumin, the antioxidant principal from curcuma longa linn., and the sulphur-containing amino acid n-acetylcysteine against ethanol-induced changes in the levels of prostanoids. biochemical assessment of liver damage was done by measuring the activities of serum enzymes (i.e., aspartate transaminase and alkaline phosphatase), which were significantly increased in rats fed ethanol, whereas the elevated levels of these enzymes wer ... | 2000 | 11120449 |
| color stability of highly filled composite resin materials for facings. | the aim of the investigation was to examine the color stability of seven resin-based facing composites with a high content of inorganic filling material (colombus, artglass, sinfony, targis, zeta lc, zeta hc, belleglass hp/dentine, belleglass hp/enamel). | 2001 | 11124418 |
| dietary strategies to counteract the effects of mycotoxins: a review. | we reviewed various dietary strategies to contain the toxic effects of mycotoxins using antioxidant compounds (selenium, vitamins, provitamins), food components (phenolic compounds, coumarin, chlorophyll and its derivatives, fructose, aspartame), medicinal herbs and plant extracts, and mineral and biological binding agents (hydrated sodium calcium aluminosilicate, bentonites, zeolites, activated carbons, bacteria, and yeast). available data are primarily from in vitro studies and mainly focus on ... | 2001 | 11198434 |
| effects of turmeric on the activities of benzo(a)pyrene-induced cytochrome p-450 isozymes. | turmeric and/or its main coloring component, curcumin (diferuloylmethane), have been shown to inhibit benzo(a)pyrene [b(a)p]-induced forestomach papillomas in mice. however, the mechanisms of turmeric-mediated chemoprevention are not well understood. to study the mechanisms of turmeric-mediated chemoprevention, we investigated the effects of turmeric feeding on the activities of isozymes of cytochrome p-450 (cyp450)--namely, ethoxyresorufin o-deethylase (erod, cyp1a1) and methoxyresorufin o-deme ... | 2001 | 11215708 |
| inhibitory effects of curcumin and capsaicin on phorbol ester-induced activation of eukaryotic transcription factors, nf-kappab and ap-1. | recently, considerable attention has been focused on identifying dietary and medicinal phytochemicals that can inhibit, retard or reverse the multi-stage carcinogenesis. spices and herbs contain phenolic substances with potent antioxidative and chemopreventive properties. curcumin, a yellow colouring agent from turmeric and capsaicin, a pungent principle of red pepper exhibit profound anticarcinogenic and antimutagenic activities. two well-defined eukaryotic transcription factors, nuclear factor ... | 2000 | 11216470 |
| characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin e2 production. | curcumin, the yellow pigment in turmeric, has been shown to prevent malignancies in a variety of tissues in rodents, especially in the intestinal tract. pharmacological activities of curcumin in cells in situ germane to chemoprevention, such as inhibition of expression of cyclooxygenase-2 (cox-2), require drug concentrations in the 10(-5) - 10(-4) m range. the systemic bioavailability of curcumin is low, so that its pharmacological activity may be mediated, in part, by curcumin metabolites. to i ... | 2001 | 11221833 |
| antioxidant phenolics and flavonoids in common indian foods. | to determine antioxidant phenolics and flavonoids in commonly consumed indian foods we chemically analysed 85 food-stuffs comprising of cereals, pulses, nuts, oilseeds, vegetables, fruits and beverages. total phenolics were measured biochemically and flavonoids were measured as a sum of quercetin, kaempferol, luteolin and pelargonidin. high flavonoid content (> 100 mg/100 gm) was present in tea, coffee, apple, guava, terminalia bark, fenugreek seeds, mustard seeds, cinnamon, red chili powder, cl ... | 1998 | 11229280 |
| inhibition of carcinogen induced c-ha-ras and c-fos proto-oncogenes expression by dietary curcumin. | we investigated the chemopreventive action of dietary curcumin on 7,12-dimethylbenz(a)anthracene (dmba)-initiated and 12,0-tetradecanoylphorbol-13-acetate (tpa)-promoted skin tumor formation in swiss albino mice. curcumin, a yellow coloring matter isolated from roots of curcuma longa linn, is a phenolic compound possessing antioxidant, free radical scavenger, and antiinflammatory properties. it has been shown by previously reported work that tpa-induced skin tumors were inhibited by topical appl ... | 2001 | 11231886 |
| [contents of free amino acids and water-soluble carbohydrates in curcuma longa l. at different stages of growth]. | closely related to the development of plant organs, the contents of free amino acids and water-soluble carbohydrates in curcuma longa vary with the course of growth. the ratio of the two contents rises with the growing periods, and reaches a maximum in the later stages of growth. | 1997 | 11243180 |
| curcuma longa activates nf-kappab and promotes adhesion of neutrophils to human umbilical vein endothelial cells. | upregulation of expression of cell adhesion molecules, such as icam-1, vcam-1 and e-selectin, is important for immune surveillance. extravasation and migration of body's effector cells to the site of immune activation is controlled by the expression of cell adhesion molecules on endothelial cells. we demonstrate here that an aqueous extract prepared from curcuma longa (claqe), a dietary component, promotes the adhesion of peripheral neutrophils to human umbilical vein endothelial cells. to delin ... | 2001 | 11282439 |
| the role of natural color additives in food allergy. | a critical evaluation of the available information demonstrates that reactions to natural color additives are rare. studies of turmeric and carotenoid pigments administered in mixtures with other food colorings failed to definitely identify reactions to either color additive. for carotenoids, the one case report of an adverse reaction was not conclusive. an anaphylactic reaction to saffron does suggest an ige-mediated reaction, but the high use of saffron as compared with this single report of a ... | 2001 | 11285683 |
| curcuminoids from curcuma longa l. (zingiberaceae) that protect pc12 rat pheochromocytoma and normal human umbilical vein endothelial cells from betaa(1-42) insult. | beta-amyloid (betaa) induced oxidative stress is a well-established pathway of neuronal cell death in alzheimer's disease. from turmeric, curcuma longa l. (zingiberaceae), three curcuminoids, curcumin, demethoxycurcumin, and bisdemethoxycurcumin, were found to protect pc12 rat pheochromocytoma and normal human umbilical vein endothelial (huvec) cells from betaa(1-42) insult, as measured by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide reduction assay. ed(50) values of curcumin, de ... | 2001 | 11297823 |
| chemical composition of turmeric oil--a byproduct from turmeric oleoresin industry and its inhibitory activity against different fungi. | curcumin, the yellow coloring pigment of turmeric is produced industrially from turmeric oleoresin. the mother liquor after isolation of curcumin from oleoresin known as curcumin removed turmeric oleoresin (crto) was extracted three times with n-hexane at room temperature for 30 min to obtain turmeric oil. the turmeric oil was subjected to fractional distillation under vacuum to get two fractions. these fractions were tested for antifugal activity against aspergillus flavus, a. parasiticus, fusa ... | 2001 | 11302211 |
| curcumin, a natural product present in turmeric, decreases tumor growth but does not behave as an anticachectic compound in a rat model. | systemic administration of curcumin [1,7-bis(4-hydroxy-3-methoxyphenil)1,6-heptadiene-3,5-dione] (20 microg/kg body weight) for 6 consecutive days to rats bearing the highly cachectic yoshida ah-130 ascites hepatoma resulted in an important inhibition of tumor growth (31% of total cell number). interestingly, curcumin was also able to reduce (24%) in vitro tumor cell content at concentrations as low as 0.5 microm without promoting any apoptotic events. although systemic administration of curcumi ... | 2001 | 11323096 |
| curcumin modifies apc(min) apoptosis resistance and inhibits 2-amino 1-methyl-6-phenylimidazo[4,5-b]pyridine (phip) induced tumour formation in apc(min) mice. | curcumin, the active ingredient of the rhizome of curcuma longa, promotes apoptosis and may have chemopreventive properties. this study investigates the effects of curcumin on apoptosis and tumorigenesis in male apc(min) mice treated with the human dietary carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (phip). intestinal epithelial apoptotic index in response to phip treatment was approximately twice as great in the wild-type c57bl/6 apc(+/+) strain than in apc(min) mice (3.7% apc(+ ... | 2001 | 11323404 |
| effect of curcumin on the apoptosis of rodent and human nonproliferating and proliferating lymphoid cells. | curcumin, a major active component of turmeric, has been recognized as an anticarcinogenic agent because of its propensity to induce apoptosis in vivo and in vitro. previously, we showed that curcumin protects cells against oligonucleosomal dna fragmentation and induces a novel apoptosis-like pathway in jurkat cells (piwocka et al. exp cell res 249, 299-307, 1999). here, we have studied the ability of curcumin to induce cell death in other human and rodent transformed as well as normal cells. no ... | 2000 | 11341039 |
| inhibition of cytochrome p450 isozymes by curcumins in vitro and in vivo. | to study the mechanism(s) of turmeric-mediated chemoprevention and to compare the chemopreventive efficacy of turmeric/curcumin(s) against benzo[a]pyrene (b(a)p) and 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (nnk, a tobacco-specific carcinogen), the effects of turmeric/curcumin (c), demethoxycurcumin (dmc), bis-demethoxycurcumin (bdmc) and phenyl and phenethyl-isothiocyanates (pitc and peitc) on the dealkylation of ethoxyresorufin (er), methoxyresorufin (mr) and pentoxyresorufin (pr) by rat l ... | 2001 | 11346483 |
| curcumin trial finds no activity. | a study by the community research initiatives of new england (crine) shows no anti-hiv activity associated with curcumin, a popular herbal medication derived from the spice turmeric. this study contrasts an earlier one done by the search alliance of los angeles, which observed a reduction in viral load. crine attempted to reproduce the earlier results by enrolling forty people in a study. two dosages were used and results were nil for both dosages. neither viral load nor cd4 counts changed signi ... | 1996 | 11363386 |
| chemical studies on antioxidant mechanism of curcumin: analysis of oxidative coupling products from curcumin and linoleate. | as a part of a research project on the antioxidant mechanism of natural phenolics in food components, curcumin, a turmeric antioxidant, was investigated in the presence of ethyl linoleate as one of the polyunsaturated lipids. during the antioxidation process, curcumin reacted with four types of linoleate peroxyl radicals. six reaction products were observed in the reaction and subsequently isolated. their structures were determined by physical techniques, revealing that they have novel tricyclic ... | 2001 | 11368633 |
| in vitro propagation and rhizome formation in curcuma longa linn. | turmeric (curcuma longa linn.) which is cultivated by underground rhizomes is a slow propagating species. multiplication and callus induction starting from the rhizome buds and shoot tips of c. longa in ms medium was carried out. a combination of naphthalene acetic acid (naa; 1.0 mg/l) with kinetin (kn; 1.0 mg/l) or naa (1.0 mg/l) with 6-benzylaminopurine (bap; 2.0 mg/l) was optimum for rapid clonal propagation of turmeric. a concentration of 2.5-3.0 mg/l of 2,4-dichlorophenoxy-acetic acid (2,4- ... | 2001 | 11393773 |
| therapeutic potential of curcumin in human prostate cancer. iii. curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of lncap prostate cancer cells in vivo. | earlier work from our laboratory highlighted the therapeutic potential of curcumin (turmeric), used as a dietary ingredient and as a natural anti-inflammatory agent in india and other southeast asian countries. this agent was shown to decrease the proliferative potential and induce the apoptosis potential of both androgen-dependent and androgen-independent prostate cancer cells in vitro, largely by modulating the apoptosis suppressor proteins and by interfering with the growth factor receptor si ... | 2001 | 11398177 |
| antifungal activity of curcuma longa grown in thailand. | curcuma longa linn. or turmeric (zingiberaceae) is a medicinal plant widely used and cultivated in tropical regions. according to thai traditional texts, fresh and dried rhizomes are used as peptic ulcer treatment, carminatives, wound treatment and anti-inflammatory agent. using hydro distillation, 1.88% and 7.02% (v/w) volatile oils were extracted from fresh and dried rhizomes, respectively, and 6.95% (w/w)crude curcuminoids were extracted from dried rhizomes. dried powder was extracted with 95 ... | 2000 | 11414453 |
| syntheses of curcumin bioconjugates and study of their antibacterial activities against beta-lactamase-producing microorganisms. | in the present study curcumin bioconjugates, viz. di-o-glycinoylcurcumin (i), di-o-glycinoyl-c(4)-glycylcurcumin (ii), 5'-deoxy-5'-curcuminylthymidine (5'-cur-t) (iv), and 2'-deoxy-2'-curcuminyluridine (2'-cur-u) (v) have been synthesized and characterized by elemental analysis and (1)h nmr. the turmeric peptide (tp) was isolated from the aqueous turmeric extract of the turmeric rhizome. the antibacterial activity of these four bioconjugates and also of the turmeric peptide and sodium salt of cu ... | 2001 | 11459448 |
| repellency of volatile oils from plants against three mosquito vectors. | volatile oils extracted by steam distillation from four plant species (turmeric (curcuma longa), kaffir lime (citrus hystrix), citronella grass (cymbopogon winterianus) and hairy basil (ocimum americanum)), were evaluated in mosquito cages and in a large room for their repellency effects against three mosquito vectors, aedes aegypti, anopheles dirus and culex quinquefasciatus. the oils from turmeric, citronella grass and hairy basil, especially with the addition of 5% vanillin, repelled the thre ... | 2001 | 11469188 |
| curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice. | protective effects of curcumin (u1), one of the major yellow pigments in turmeric and its derivative, tetrahydrocurcumin (thu1), against ferric nitrilotriacetate (fe-nta)-induced oxidative renal damage were studied in male ddy mice. single fe-nta treatment (5 mg fe/kg body intraperitoneally) transiently causes oxidative stress, as shown by the accumulation of lipid peroxidation products and 8-hydroxy-2'-deoxyguanosine in the kidney. mice were fed with a diet containing 0.5 g/100 g u1 or thu1 for ... | 2001 | 11481399 |
| phase ii clinical trial on effect of the long turmeric (curcuma longa linn) on healing of peptic ulcer. | the study examined patients who had symptoms indicating peptic ulcer. forty-five patients, 24 males and 21 females, aged between 16-60 years were included in the study. twenty-five patients, 18 males and 7 females, were endoscoped, their ulcers located in the duodenal bulb and gastric (angulus). the ulcer sizes varied between 0.5 to 1.5 cm in diameter. capsule-filled turmeric was given orally in the dose of 2 capsules (300 mg each) five times daily, one half to an hour before meals, at 16.00 hou ... | 2001 | 11485087 |
| biological activities of curcuma longa l. | there are several data in the literature indicating a great variety of pharmacological activities of curcuma longa l. (zingiberaceae), which exhibit anti-inflammatory, anti-human immunodeficiency virus, anti-bacteria, antioxidant effects and nematocidal activities. curcumin is a major component in curcuma longa l., being responsible for its biological actions. other extracts of this plant has been showing potency too. in vitro, curcumin exhibits anti-parasitic, antispasmodic, anti-inflammatory a ... | 2001 | 11500779 |
| molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of cox-2 and inos through suppression of nf-kappa b activation. | a wide array of phenolic substances, particularly those present in edible and medicinal plants, have been reported to possess substantial anticarcinogenic and antimutagenic activities. the majority of naturally occurring phenolics retain antioxidative and anti-inflammatory properties which appear to contribute to their chemopreventive or chemoprotective activity. cyclooxygenase-2 (cox-2) inducible and nitric oxide synthase (inos) are important enzymes that mediate inflammatory processes. imprope ... | 2001 | 11506818 |
| essential oil composition and antimicrobial activity of three zingiberaceae from s.tomé e príncipe. | the essential oil composition of three zingiberaceae widely used as medicinal aromatic plants from s. tomé and príncipe: aframomum danielli (hook. f.) k. schum., curcuma longa l. and zingiber officinale rosc. was studied. two samples of the essential oils from fruit of a. danielli and from rhizomes of the other two species, were obtained by hydrodistillation and analyzed by gc, gc-ms, and (13)c-nmr. the essential oil from fruits of a. danielli has been studied for the first time and was characte ... | 2001 | 11509990 |
| effect of glutathione depletion on caspase-3 independent apoptosis pathway induced by curcumin in jurkat cells. | curcumin, a yellow pigment from curcuma longa, exhibits anti-inflammatory, antitumor, and antioxidative properties. although its precise mode of action has not been elucidated so far, numerous studies have shown that curcumin may induce apoptosis in normal and cancer cells. previously, we showed that in jurkat cells curcumin induced nontypical apoptosis-like pathway, which was independent of mitochondria and caspase-3. now we show that the inhibition of caspase-3 by curcumin, which is accompanie ... | 2001 | 11522452 |
| protection of radiation-induced protein damage by curcumin. | free radical reactions of lysozyme (lz), tryptophan and disulfides were studied with curcumin, a lipid-soluble antioxidant from turmeric, in aqueous solution using a pulse radiolysis technique. the binding of curcumin with lysozyme was confirmed using absorption, fluorescence and stopped-flow techniques. the free radicals of curcumin generated after repairing radicals of disulfides, lysozyme and tryptophan absorb at 500-510 nm. implication of this in evaluating the antioxidant behavior of curcum ... | 2001 | 11527584 |
| [study on the characterizations of genus curcuma plants on the strains of c. longa l. and c. aromatica salisb preserved at izu station of nihs]. | to clarify the characteristics of genus curcuma plants, we studied the properties of six strains of curcuma longa l. and two strains of c. aromatica salisb. preserved at izu experimental station for medicinal plants of national institute of health sciences. six strains of c. longa were classified into three types according to morphological characteristics, rhizome production, and differences in curcuminoid content of rhizome. the curcuminoid content of the rhizomes in each strain ranged from 2.2 ... | 2000 | 11534130 |
| inhibition of invasion and induction of apoptosis by curcumin in h-ras-transformed mcf10a human breast epithelial cells. | curcumin, a dietary pigment in turmeric, posseses anti-carcinogenic and anti-metastatic properties. the present study was conducted to study in vitro chemopreventive effects of curcumin in transformed breast cells. here, we show that curcumin inhibits h-ras-induced invasive phenotype in mcf10a human breast epithelial cells (h-ras mcf10a) and downregulates matrix metalloproteinase (mmp)-2 dose-dependently. curcumin exerted cytotoxic effect on h-ras mcf10a cells in a concentration-dependent manner ... | 2001 | 11534770 |
| total synthesis of calebin-a, preparation of its analogues, and their neuronal cell protectivity against beta-amyloid insult. | a total synthesis of calebin-a (1), a novel curcuminoid isolated from turmeric (curcuma longa, zingiberaceae) that has been demonstrated to protect neuronal cells from beta-amyloid insult, was successfully achieved in four steps. elaborating on this synthetic route, 13 analogues were prepared for a structure-activity relationship (sar) study. it was found that the parent compound 1 and derivatives 21, 28, and 30 protect pc12 rat pheocromocytoma and imr-32 human neuroblastoma cells from beta-amyl ... | 2001 | 11549465 |
| occurrence of ochratoxin a in black pepper, coriander, ginger and turmeric in india. | ochratoxin a (oa) contamination of black pepper, coriander seeds, powdered ginger and turmeric powder was estimated using indirect competitive elisa. samples (1 g) were extracted with 0.5% potassium chloride (kcl) in 70% methanol (5 ml) and diluted subsequently to give two-fold to ten-fold step-wise dilutions in phosphate-buffered saline containing 0.05% tween 20 and 0.2% bovine serum albumin (pbs-t bsa). for extracts from the spices analysed, elisa estimates of oa concentrations were compared w ... | 2001 | 11552750 |
| specific inhibition of cyclooxygenase-2 (cox-2) expression by dietary curcumin in ht-29 human colon cancer cells. | curcumin, a major yellow pigment and active component of turmeric, has been shown to possess anti-inflammatory and anti-cancer activities. cyclooxygenase (cox)-2 plays an important role in colon carcinogenesis. to investigate the effect of curcumin on cox-2 expression, we treated ht-29 human colon cancer cells with various concentrations of curcumin. curcumin inhibited the cell growth of ht-29 cells in a concentration- and time-dependent manner. curcumin markedly inhibited the mrna and protein e ... | 2001 | 11566484 |
| curcuma longa (turmeric). monograph. | curcuma longa, a perennial herb, is a member of the zingiberaceae (ginger) family. the plant grows to a height of three to five feet, and is cultivated extensively in asia, india, china, and other countries with a tropical climate. it has oblong, pointed leaves and bears funnel-shaped yellow flowers. the rhizome is the portion of the plant used medicinally; it is usually boiled, cleaned, and dried, yielding a yellow powder. dried curcuma longa is the source of the spice turmeric, the ingredient ... | 2001 | 11591174 |
| effects of curcuma longa on proliferation of cultured bovine smooth muscle cells and on expression of low density lipoprotein receptor in cells. | to investigate the inhibitory effects of aqueous turmeric extract (aqt) and serum of rats orally treated with ethanol extract of turmeric (set) on proliferation of vascular smooth muscle cells (vsmc) and its effects on the expression of low density lipoprotein receptor (ldl-r) antigen on the surface of smooth muscle cells. | 1999 | 11593527 |
| [effect of turmeric volatile oil on the respiratory tract]. | researching the effect of turmeric volatile oil on functions of the respiratory tract. | 1998 | 11599365 |
| the curry spice curcumin reduces oxidative damage and amyloid pathology in an alzheimer transgenic mouse. | inflammation in alzheimer's disease (ad) patients is characterized by increased cytokines and activated microglia. epidemiological studies suggest reduced ad risk associates with long-term use of nonsteroidal anti-inflammatory drugs (nsaids). whereas chronic ibuprofen suppressed inflammation and plaque-related pathology in an alzheimer transgenic appsw mouse model (tg2576), excessive use of nsaids targeting cyclooxygenase i can cause gastrointestinal, liver, and renal toxicity. one alternative n ... | 2001 | 11606625 |
| mechanisms of curcumin-induced apoptosis of ehrlich's ascites carcinoma cells. | curcumin, the active ingredient from the spice turmeric (curcuma longa linn), is a potent antioxidant and anti-inflammatory agent. it has been recently demonstrated to possess discrete chemopreventive activities. however, the molecular mechanisms underlying such anticancer properties of curcumin still remain unrealized, although it has been postulated that induction of apoptosis in cancer cells might be a probable explanation. in the current study, curcumin was found to decrease the ehrlich's as ... | 2001 | 11676493 |
| curcumin-induced differentiation of mouse embryonal carcinoma pcc4 cells. | curcumin, a natural component of turmeric extracted from the rhizomes of curcuma longa, is known to exhibit a number of biological properties. in the present study, curcumin, at low concentration, was shown to induce differentiation in embryonal carcinoma cell line pcc4. in response to curcumin, pcc4 cells ceased to proliferate and showed cell cycle arrest at g1 phase after 4 hours of treatment, followed by their differentiation which is characterized by increase of nuclear/cytoplasmic ratio. th ... | 2001 | 11686235 |
| dietary curcuminoids prevent high-fat diet-induced lipid accumulation in rat liver and epididymal adipose tissue. | curcumin and its structurally related compounds (curcuminoids), the phenolic yellowish pigments of turmeric, display antioxidative, anticarcinogenic and hypocholesterolemic activities. in this study, we investigated the effects of dietary supplemented curcuminoids [commercial grade curcumin: a mixture of curcumin (73.4%), demethoxycurcumin (16.1%) and bisdemethoxycurcumin (10.5%)] on lipid metabolism in rats. male sprague-dawley rats were assigned to three diet groups (n = 6) and fed a moderatel ... | 2001 | 11694621 |
| herbals, cancer prevention and health. | the use of herbs for medical benefit has played an important role in nearly every culture on earth. herbal medicine was practiced by ancient cultures in asia, africa, europe and the americas. the recent popularity in use of herbals can be tied to the belief that herbs can provide some benefit over and above allopathic medicine and allow users to feel that they have some control in their choice of medications. the widespread use of herbs, either directly or as dietary supplements, has raised many ... | 2001 | 11694643 |
| curcumin, a medicinal herbal compound capable of inducing the heat shock response. | there is interest in developing pharmacologic inducers of the heat shock response as a means to confer cytoprotection in the clinical setting. we propose that a potential strategy for screening novel pharmacologic inducers of the heat shock response is to examine known inhibitors of the transcription factor nuclear factor-kappab. curcumin, derived from the tropical herb curcuma longa, is a recently described inhibitor of nuclear factor-kappab and is widely used in eastern medicinal practices. we ... | 2001 | 11700423 |
| protective effects of curcumin against oxidative damage on skin cells in vitro: its implication for wound healing. | curcumin, isolated from turmeric, has been known to possess many pharmacologic properties. it has been proven to exhibit remarkable anticarcinogenic, anti-inflammatory, and antioxidant properties. turmeric curcumin may be a good potential agent for wound healing. | 2001 | 11706342 |