Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| activation of apoptotic protein in u937 cells by a component of turmeric oil. | aromatic (ar)-turmerone from turmeric oil displays anti-tumorigenesis activity that includes inhibited cell proliferation. this study investigated ar-turmerone-mediated apoptotic protein activation in human lymphoma u937 cells. ar-turmerone treatment inhibited u937 cell viability in a concentration-dependent fashion, with inhibition exceeding 84%. moreover, the treatment produced nucleosomal dna fragmentation and the percentage of sub-diploid cells increased in a concentration-dependent manner; ... | 2009 | 19250610 |
| determining the effects of lipophilic drugs on membrane structure by solid-state nmr spectroscopy: the case of the antioxidant curcumin. | curcumin is the active ingredient of turmeric powder, a natural spice used for generations in traditional medicines. curcumin's broad spectrum of antioxidant, anticarcinogenic, antimutagenic, and anti-inflammatory properties makes it particularly interesting for the development of pharmaceutical compounds. because of curcumin's various effects on the function of numerous unrelated membrane proteins, it has been suggested that it affects the properties of the bilayer itself. however, a detailed a ... | 2009 | 19256547 |
| curcuminoid biosynthesis by two type iii polyketide synthases in the herb curcuma longa. | curcuminoids found in the rhizome of turmeric, curcuma longa, possess various biological activities. despite much attention regarding the biosynthesis of curcuminoids because of their pharmaceutically important properties and biosynthetically intriguing structures, no enzyme systems have been elucidated. here we propose a pathway for curcuminoid biosynthesis in the herb c. longa, which includes two novel type iii polyketide synthases. one of the type iii polyketide synthases, named diketide-coa ... | 2009 | 19258320 |
| binding and stabilization of transthyretin by curcumin. | biophysical evidences suggest that transthyretin (ttr) tetramer dissociation to the monomeric intermediate and subsequent polymerization leads to amyloid fibril formation, which is implicated in the pathogenesis of familial amyloid polyneuropathy (fap) and senile systemic amyloidosis (ssa). hence, inhibition of fibril formation is considered a potential therapeutic strategy. here in we demonstrate that curcumin, a phenolic constituent of curry spice turmeric, binds to the active site of ttr thro ... | 2009 | 19268650 |
| turmeric: the intriguing yellow spice with medicinal properties. | 2016 | 19272583 | |
| pharmacokinetics prediction and drugability assessment of diphenylheptanoids from turmeric (curcuma longa l). | cheminformatics approaches are currently not employed in any of the spices to study the medicinal properties traditionally attributed to them. the aim of this study is to find the most efficacious molecule which do not have toxic effects but at the same time have desired pharmacokinetic profile. in the present study of the class 'diphenylheptanoids' from turmeric, cheminformatics methods were employed to predict properties such as physicochemical properties, absorption, distribution, metabolism, ... | 2009 | 19275711 |
| a simple hplc-fluorescence method for quantitation of curcuminoids and its application to turmeric products. | an hplc method using fluorescence detection for the quantitation of curcuminoids, such as curcumin (c), demethoxycurcumin (dmc), and bisdemethoxycurcumin (bdmc) in turmeric products is described. this method involves a simple ultrasonic extraction with methanol as a pretreatment of turmeric products. the separation of curcuminoids and 2,5-xylenol (internal standard) was achieved within 30 min on a cadenza cd-c(18) column (250 x 4.6 mm; i.d., 3 microm) with a mixture of acetate buffer and ch(3)cn ... | 2009 | 19276595 |
| molecular and biochemical diversity among isolates of radopholus spp. from different areas of the world. | eleven isolates of radopholus similis from various banana-growing areas around the world and one isolate of r. bridgei from turmeric in indonesia were compared using dna and isoenzyme analysis. the polymerase chain reaction (pcr) was used to amplify a fragment of ribosomal dna (rdna), comprising the two internal transcribed spacers (its) and the 5.8s gene. restriction fragment length polymorphisms (rflps) in this rdna fragment were used to compare the 10 isolates. the analysis of this rdna regio ... | 1996 | 19277160 |
| further examination of antiradical properties of crocus sativus stigmas extract rich in crocins. | data for antiradical properties of saffron extract and its bioactive constituents (crocins, crocetin) are limited and poorly discussed in comparison with those of extracts containing potent scavengers. further examination was sought using the folin-ciocalteu (f-c) reagent and various free radical species produced in cell-free or cell model systems. oregano and turmeric methanol extracts, rich in well established scavengers, and also crocetin, rosmarinic acid, and curcumin, representing the major ... | 2009 | 19284715 |
| prophylactic role of curcumin in dextran sulfate sodium (dss)-induced ulcerative colitis murine model. | we have addressed in this study the possible protective role of the main principle of turmeric pigment; curcumin on a murine model of ulcerative colitis (uc). colitis was induced by administration of dextran sulfate sodium (dss) (3% w/v) in drinking water to male swiss albino rats for 5 consecutive days. dss challenge induced uc model that was well characterized morphologically and biochemically. dss produced shrinkage of colon length and increased the relative colon weight/length ratio accompan ... | 2009 | 19285535 |
| curcumin inhibits proliferation and migration by increasing the bax to bcl-2 ratio and decreasing nf-kappabp65 expression in breast cancer mda-mb-231 cells. | curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), is extracted from the plant curcuma longa. it has cytotoxic effects and induces apoptosis in many human cancer cells but the molecular mechanisms are not fully understood. in the present study, we evaluated the effects of curcumin on human breast cancer mda-mb-231 cells. the cytotoxic effects of curcumin on mda-mb-231 cells were measured by mtt assay. the percentages of cell cycle were determined by flow cytometry. the prote ... | 2009 | 19288022 |
| curcumin inhibits adipogenesis in 3t3-l1 adipocytes and angiogenesis and obesity in c57/bl mice. | angiogenesis is necessary for the growth of adipose tissue. dietary polyphenols may suppress growth of adipose tissue through their antiangiogenic activity and by modulating adipocyte metabolism. we investigated the effect of curcumin, the major polyphenol in turmeric spice, on angiogenesis, adipogenesis, differentiation, apoptosis, and gene expression involved in lipid and energy metabolism in 3t3-l1 adipocyte in cell culture systems and on body weight gain and adiposity in mice fed a high-fat ... | 2009 | 19297423 |
| curcumin eliminates leptin's effects on hepatic stellate cell activation via interrupting leptin signaling. | nonalcoholic steatohepatitis (nash) is commonly found in patients with obesity and is often accompanied with abnormally elevated levels of plasma leptin, i.e. hyperleptinemia. a relatively high population of nash patients develops hepatic fibrosis, even cirrhosis. hepatic stellate cells (hscs) are the major effector cells during liver fibrogenesis and could be activated by leptin. the antioxidant curcumin, a phytochemical from turmeric, has been shown to suppress hsc activation in vitro and in v ... | 2009 | 19299451 |
| antidepressant-like effects of curcumin on serotonergic receptor-coupled ac-camp pathway in chronic unpredictable mild stress of rats. | serotonergic receptors take their physiologic effects by affecting adenylyl cyclase (ac) catalytic activity and cyclic adenosine monophosphate (camp) concentration. ac-camp second messenger pathway has been recently suggested to play an important role in depression. therefore, the compound that regulates the signal pathway may have potential as antidepressant. curcumin is the main component of curcuma longa l, a well-known indigenous herb with comprehensive bioactivities. in the present study, w ... | 2009 | 19302828 |
| modulation of in vitro murine b-lymphocyte response by curcumin. | curcumin is a phenolic natural product isolated from the rhizome of curcuma longa (tumeric). it was previously described that curcumin had a potent anti-inflammatory effect and inhibited the proliferation of a variety of tumor cells. in the present study, we investigated the inhibitory effects of curcumin on the response of normal murine splenic b cells. curcumin inhibited the proliferative response of purified splenic b cells from balb/c mice stimulated with the toll-like receptor ligands lps a ... | 2009 | 19303754 |
| tea polyphenols and their roles in cancer prevention and chemotherapy. | many plant-derived, dietary polyphenols have been studied for their chemopreventive and chemotherapeutic properties against human cancers, including green tea polyphenols, genistein (found in soy), apigenin (celery, parsley), luteolin (broccoli), quercetin (onions), kaempferol (broccoli, grapefruits), curcumin (turmeric), etc. the more we understand their involved molecular mechanisms and cellular targets, the better we could utilize these "natural gifts" for the prevention and treatment of huma ... | 2008 | 19325799 |
| amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of alzheimer's type (sdat). | recent evidence indicates that curcumin (cur), the principal curcuminoid of turmeric, exhibits antioxidant potential and protects the brain against various oxidative stressors. the aim of the present study was to examine the modulating impacts of cur against cognitive deficits and oxidative damage in intracerebroventricular-streptozotocin (icv-stz) infused rats. rats were injected bilaterally with icv-stz (3 mg/kg), while sham rats received the same volume of vehicle and then supplemented with c ... | 2009 | 19329286 |
| curcumin synergizes the growth inhibitory properties of indian toad (bufo melanostictus schneider) skin-derived factor (bm-anf1) in hct-116 colon cancer cells. | curcumin, an active ingredient of turmeric with no discernable toxicity, inhibits the growth of transformed cells and the development and progression of colon carcinogenesis in experimental animals. recent data from one of our laboratories demonstrated that a crude skin extract or a purified crystalline compound (bufo melanostictus-antineoplastic factor 1, bm-anf1) from indian common toad (bufo melanostictus, schneider) skin inhibits the growth of human leukemic cells. the present investigation ... | 2009 | 19331178 |
| new structural analogues of curcumin exhibit potent growth suppressive activity in human colorectal carcinoma cells. | colorectal carcinoma is one of the major causes of morbidity and mortality in the western world. novel therapeutic approaches are needed for colorectal carcinoma. curcumin, the active component and yellow pigment of turmeric, has been reported to have several anti-cancer activities including anti-proliferation, anti-invasion, and anti-angiogenesis. clinical trials have suggested that curcumin may serve as a potential preventive or therapeutic agent for colorectal cancer. | 2009 | 19331692 |
| uses of turmeric in dentistry: an update. | turmeric has been used for thousands of years as a dye, a flavoring, and a medicinal herb. in india, it has been used traditionally as a remedy for stomach and liver ailments, as well as topically to heal sores. ancient indian medicine has touted turmeric as an herb with the ability to provide glow and luster to the skin as well as vigor and vitality to the entire body. since turmeric has antimicrobial, antioxidant, astringent, and other useful properties, it is quite useful in dentistry also. t ... | 2015 | 19336870 |
| systematic review of the management of canine osteoarthritis. | this review assesses the evidence for the efficacy of therapies used in the management of osteoarthritis in dogs on the basis of papers published in peer-reviewed journals in english between 1985 and july 2007. sixty-eight papers were identified and evaluated. they considered four alternative therapies, one use of functional food, two intra-articular agents, six nutraceutical agents, 21 pharmacological agents, two physical therapies, three surgical techniques and two combinations of weight contr ... | 2009 | 19346540 |
| curcumin blocks ccl2-induced adhesion, motility and invasion, in part, through down-regulation of ccl2 expression and proteolytic activity. | expression and activity of cc motif ligand 2 (ccl2) is down-regulated by curcumin, the active phytochemical ingredient of turmeric (curcuma longa), a dietary supplement often self-prescribed to promote prostate health. ccl2 is a potent chemotactic factor of prostate cancer (pca) with important roles in development of bone metastasis. the relationship between ccl2 and curcumin, however, has not been studied in pca. adhesion, invasion and motility of pc-3 cells were measured in response to exposur ... | 2009 | 19360344 |
| curcumin binding to dna and rna. | curcumin, the yellow pigment from the rhizoma of curcuma longa, is a widely studied phytochemical with a variety of biological activities. the ongoing research and clinical trials have proved that this natural phenolic compound has great and diverse pharmacological potencies. beside its effective antioxidant, antiinflammatory, and antimicrobial/antiviral properties, curcumin is also considered as a cancer chemopreventive agent. while the antioxidant activity of curcumin is well documented, its i ... | 2009 | 19364279 |
| curcumin blocks brain tumor formation. | turmeric, an essential ingredient of culinary preparations of southeast asia, contains a major polyphenolic compound, named curcumin or diferuloylmethane, which eliminates cancer cells derived from a variety of peripheral tissues. although in vitro experiments have addressed its anti-tumor property, no in vivo studies have explored its anti-cancer activity in the brain. oral delivery of this food component has been less effective because of its low solubility in water. we show that a soluble for ... | 2009 | 19368804 |
| design and optimization of ultrasound assisted extraction of curcumin as an effective alternative for conventional solid liquid extraction of natural products. | the first step in the qualitative and quantitative analysis of medicinal plant constituents is the extraction step. ideally, an extraction procedure should be exhaustive with respect to the constituents to be analyzed, rapid, simple, and for routine analysis amenable to automation. usually, the traditional techniques require long extraction times, with more consumption of energy resources and organic solvent, have low efficiency and are often unsafe for thermolabile botanicals. the taguchi based ... | 2009 | 19370883 |
| curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model. | curcumin (diferuloylmethane), a yellow pigment in turmeric, has been shown to inhibit the activation of nuclear factor-kappab (nf-kappab), a transcription factor closely linked to chemoresistance in multiple myeloma cells. whether curcumin can overcome chemoresistance and enhance the activity of thalidomide and bortezomib, used to treat patients with multiple myeloma, was investigated in vitro and in xenograft model in nude mice. our results show that curcumin inhibited the proliferation of huma ... | 2009 | 19372569 |
| curcumin arrests endometriosis by downregulation of matrix metalloproteinase-9 activity. | curcumin, a polyphenol derived from turmeric (curcuma longa) possesses diverse pharmacological properties including antioxidant, anti-inflammatory and antiproliferative activities. endometriosis is a gyneocological disorder characterized by growth of endometrial tissues outside uterus that involves aberrant matrix remodeling. in this study the effect of curcumin was studied on surgically developed endometriosis in mice. endometriosis with varying severity was developed in mice by peritoneal impl ... | 2009 | 19374255 |
| curcumin attenuates aluminium-induced functional neurotoxicity in rats. | curcumin is a polyphenol extracted from the rhizome of curcuma longa and well known as a multi-functional drug with antioxidative, anti-cancerous and anti-inflammatory activities. curcumin's antiaging and neuroprotective potential is widely reported. in the present study, effect of curcumin treatment dose 30 mg kg(-1) day(-1) was investigated against aluminium neurotoxicity in young and old animals. direct and indirect intakes of aluminium have been reported to be involved in the etiology of sev ... | 2009 | 19376155 |
| green tea, vitamins d and b, milk thistle, cranberries, and turmeric top list of ingredients ranked; call for methods issued. | 2009 | 19382549 | |
| curcumin in combination with bortezomib synergistically induced apoptosis in human multiple myeloma u266 cells. | growth of multiple myeloma cells is controlled by various factors derived from host bone marrow microenvironments. interaction between multiple myeloma cells and bone marrow stromal cells (bmscs) plays an important role in the expression of adhesive molecules and secretion of growth factors involved in multiple myeloma (mm) cell growth, survival, and resistance to anticancer drugs. recently, the possibility of developing novel anti-cancer therapeutic strategies targeting both mm cells and mm cel ... | 2008 | 19383353 |
| curcumin analogues exhibit enhanced growth suppressive activity in human pancreatic cancer cells. | curcumin, a yellow pigment and the active component of turmeric, has been shown to protect against carcinogenesis and prevent tumor development in several types of cancer. however, its low bioavailability and potency prevent it from being effective in most chemotherapeutic applications. one potential means of circumventing this problem has been the creation of synthetic curcumin analogues. we tested the efficacy of two such analogues, known as flll11 and flll12, in human pancreatic cancer cell l ... | 2009 | 19384191 |
| effects of curcuminoid supplement on cardiac autonomic status in high-fat-induced obese rats. | sudden cardiac death in obesity is frequently associated with sympathetic activation due to an elevated plasma free-fatty acid (ffa) level. curcuminoids, the phenolic yellowish pigments of turmeric, display antioxidative and lipid-lowering activities. we hypothesized that curcuminoids ameliorate cardiac sympathovagal disturbance in high-fat-induced obese rats. | 2009 | 19398300 |
| a simple isocratic hplc method for the simultaneous determination of curcuminoids in commercial turmeric extracts. | turmeric (curcuma longa) extracts contain three curcuminoids (curcumin, desmethoxycurcumin and bisdesmethoxycurcumin) as major bioactive substances. previously reported hplc-uv methods for the determination of curcuminoids have several disadvantages, including unsatisfactory separation times, poor resolution and/or complicated solvent mixtures with gradient elution. | 2013 | 19402187 |
| antiviral effect of curcuma longa linn extract against hepatitis b virus replication. | a medicinal herb curcuma longa linn has been used for treating various liver diseases caused by hepatitis b virus (hbv) in asia. | 2009 | 19409970 |
| isolation of dihydrocurcuminoids from cell clumps and their distribution in various parts of turmeric (curcuma longa). | in addition to well-known curcuminoids, three colored metabolites were isolated from cultured cell clumps that had been induced from buds on turmeric rhizomes. the isolated compounds were identified as dihydro derivatives of curcuminoids, dihydrocurcumin (dihydrocurc), dihydrodesmethoxycurcumin-a (dihydrodmc-a), and dihydrobisdesmethoxycurcumin (dihydrobdmc). the cell clumps did not contain dihydrodmc-b, an isomer of dihydrodmc-a. a comparison of the distribution profiles of curcuminoids and dih ... | 2009 | 19420708 |
| demethoxycurcumin induces bcl-2 mediated g2/m arrest and apoptosis in human glioma u87 cells. | docking analysis of curcumin (c1), demethoxycurcumin (c2) and bisdemethoxycurcumin (c3) with bcl-2 illustrated that among the three curcuminoids, c2 binds more efficiently into its putative active site. c1, c2 and c3 were purified from turmeric rhizomes to demonstrate the molecular mechanism of their anticancer activity on human glioma u87 cells. human glioma u87 cells treated with curcuminoids resulted in activation of bcl-2 mediated g2 checkpoint, which was associated with the induction of g2/ ... | 2009 | 19422808 |
| curcumin protects neuronal cells from japanese encephalitis virus-mediated cell death and also inhibits infective viral particle formation by dysregulation of ubiquitin-proteasome system. | japanese encephalitis (je) is an arboviral disease common in southeast asia encompassing a population of 3 billion people. periodic outbreak of je takes hundreds of lives. children are major victims of je. about one third of je patients die, and many of the survivors suffer from permanent neuropsychiatric sequel, owing to the lack of specific therapeutic measure. curcumin is a naturally occurring phenolic compound extracted from curcuma longa l. previous studies have reported that curcumin posse ... | 2009 | 19434500 |
| bubbling hookah smoke through heat-solubilized curcumin/turmeric and incorporation of the curry spice as an additive or filter in cigarettes to minimize tobacco smoke-related toxicants. | 2009 | 19435657 | |
| reversible antifertility effect of aqueous rhizome extract of curcuma longa l. in male laboratory mice. | the purpose of the present study was to evaluate the antifertility potential of curcuma longa l. in the male laboratory mouse. | 2009 | 19442785 |
| curcumin prevents human aortic smooth muscle cells migration by inhibiting of mmp-9 expression. | the migration of vascular smooth muscle cells from the tunica media to the subendothelial region is a key event in the development of atherosclerosis. curcumin, which is consumed daily by millions of people, is a polyphenol derived from the plant curcuma longa. in this study, we investigated the effects of curcumin on tumor necrosis factor-alpha (tnf-alpha)-induced cell migration, the formation of intracellular reactive oxygen species (ros), the translocation of nuclear factor-kappab (nfkappab) ... | 2010 | 19447587 |
| the role of curcuma longa against doxorubicin (adriamycin)-induced toxicity in rats. | the major component, called curcumin, of turmeric (curcuma longa l.) (family zingiberaceae) powder is responsible for its biological actions. the present study aimed to prove the protective effect of turmeric extract against doxorubicin (dox)-induced cardiac, hepatic, and renal toxicity as evaluated in rats. body weight and urine volume of the animal groups under investigation were recorded daily throughout the experimental period. also, the cardiac, hepatic, and renal toxicities were determined ... | 2009 | 19459743 |
| new synthetic glucosyl-curcuminoids, and their (1)h and (13)c nmr characterization, from curcuma longa l. | turmeric extracts, among which curcumin and bis-demethoxycurcumin, are by far known for their therapeutic activities. in this study we propose easy and low cost synthetic pathways in order to obtain glucosyl-curcuminoids, safe and water soluble potential drugs and dyes, which may be implied in different fields ranging from pharmacology to food chemistry. the complete (1)h and (13)c nmr characterization of naturally occurring curcumin, bis-demethoxycurcumin and new synthetic glucosyl-curcuminoids ... | 2009 | 19462241 |
| curcumin, a potential inhibitor of up-regulation of tnf-alpha and il-6 induced by palmitate in 3t3-l1 adipocytes through nf-kappab and jnk pathway. | to investigate the attenuating effect of curcumin, an anti-inflammatory compound derived from dietary spice turmeric (curcuma longa) on the pro-inflammatory insulin-resistant state in 3t3-l1 adipocytes. | 2009 | 19462685 |
| partially purified curcuma longa inhibits alpha-melanocyte-stimulating hormone-stimulated melanogenesis through extracellular signal-regulated kinase or akt activation-mediated signalling in b16f10 cells. | bioassay-guided fractionation of curcuma longa by solvent partitioning and purification with octadecylsilane open column chromatography yielded a partial purification. the active 80% methanol chromatographic fraction from the ethyl acetate layer [partial purification from c. longa (ppc)] was used to investigate the alpha-melanocyte-stimulating hormone (alpha-msh)-stimulated melanogenesis signal pathway in b16f10 cells. in cells stimulated alpha-msh, ppc inhibited cellular melanin contents, tyros ... | 2009 | 19469902 |
| curcumin modulates efflux mediated by yeast abc multidrug transporters and is synergistic with antifungals. | curcumin (cur), a natural product of turmeric, from rhizomes of curcuma longa, is a known agent of reversal of drug resistance phenotypes in cancer cells overexpressing atp-binding cassette (abc) transporters, viz., abcb1, abcg2, and abcc1. in the present study, we evaluated whether cur could also modulate multidrug transporters of yeasts that belong either to the abc family or to the major facilitator superfamily (mfs). the effect of cur on multidrug transporter proteins was demonstrated by exa ... | 2009 | 19470507 |
| in vitro screening for anthelmintic and antitumour activity of ethnomedicinal plants from thailand. | this study screened for anthelmintic and/or antitumour bioactive compounds from thai indigenous plants and evaluated effectiveness against three different worm species and two cancer cell lines. | 2009 | 19473794 |
| curcumin inhibits the migration and invasion of human a549 lung cancer cells through the inhibition of matrix metalloproteinase-2 and -9 and vascular endothelial growth factor (vegf). | it is well known that matrix metalloproteinases (mmps) act an important role in the invasion, metastasis and angiogenesis of cancer cells. agents suppressed the mmps could inhibited the cancer cells migration and invasion. numerous evidences had shown that curcumin (the active constituent of the dietary spice turmeric) has potential for the prevention and therapy of cancer. curcumin can inhibit the formation of tumors in animal models of carcinogenesis and act on a variety of molecular targets i ... | 2009 | 19477063 |
| curcumin inhibits cellular condensation and alters microfilament organization during chondrogenic differentiation of limb bud mesenchymal cells. | curcumin is a well known natural polyphenol product isolated from the rhizome of the plant curcuma longa, anti-inflammatory agent for arthritis by inhibiting synthesis of inflammatory prostaglandins. however, the mechanisms by which curcumin regulates the functions of chondroprogenitor, such as proliferation, precartilage condensation, cytoskeletal organization or overall chondrogenic behavior, are largely unknown. in the present report, we investigated the effects and signaling mechanism of cur ... | 2009 | 19478554 |
| hypotensive and endothelium-independent vasorelaxant effects of methanolic extract from curcuma longa l. in rats. | curcuma longa l. (cl) is a yellow rhizome that is used in african traditional medicine to treat palpitation, hypertension or other related blood circulation disorders. | 2009 | 19481144 |
| simple hplc method for resolution of curcuminoids with antioxidant potential. | development of methodology for qualitative analysis and quantitative separation of individual curcuminoids in curcumin removed turmeric oleoresin (crto) and study of antioxidant activity of individual curcuminoids have been achieved in the present study. a simple hplc protocol was outlined for optimal resolution of curcuminoids (i), (ii), and (iii) on an exil-nh(2) column using isocratic elution with a mixture of isopropanol and water. crto is shown to be good source for the compounds ii and iii ... | 2013 | 19490317 |
| nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer. | curcumin, a derived product from common spice turmeric that is safe and beneficial in several aliments was formulated into biodegradable nanoparticles with a view to improve its oral bioavailability. the curcumin encapsulated nanoparticles prepared by emulsion technique were spherical in shape with particle size of 264nm (polydispersity index 0.31) and 76.9% entrapment at 15% loading. the curcumin encapsulated nanoparticles were able to withstand the international conference on harmonisation (ic ... | 2009 | 19491009 |
| development of curcuminoids loaded poly(butyl) cyanoacrylate nanoparticles: physicochemical characterization and stability study. | curcumininoids, obtained from the rhizomes of curcuma longa l., zingiberaceae (turmeric), are the most widely used phytoconstituent in food industry and recently for its therapeutic activity. it has very wide spectrum of therapeutic use like in inflammation, psoriasis, various tumors, wound healing and also in neurodegenerative diseases like alzheimer's disease. but its highly lipophilic nature and very poor bioavailability hampers its therapeutic usefulness. poly(butyl) cyanoacrylate (pbca) nan ... | 2009 | 19491031 |
| analysis of binding interaction of curcumin and diacetylcurcumin with human and bovine serum albumin using fluorescence and circular dichroism spectroscopy. | the current study reports the binding of curcumin (cur) as the main pharmacologically active ingredient of turmeric and diacetylcurcumin (dac) as a bioactive derivative of curcumin to human serum albumin (hsa) and bovine serum albumin (bsa). the apparent binding constants and number of substantive binding sites have been evaluated by fluorescence quenching method. the distance (r) between donor (hsa and bsa) and acceptor (cur and dac) was obtained on the basis of the förster's theory of non-radi ... | 2009 | 19495944 |
| effects of curcumin for preventing restenosis in a hypercholesterolemic rabbit iliac artery stent model. | to evaluate the efficacy of the curcumin-coating stent (ccs) on the inhibition of restenosis in a rabbit iliac artery stent model. | 2009 | 19496118 |
| systemic delivery of curcumin: 21st century solutions for an ancient conundrum. | curcumin, a polyphenolic compound derived from the dietary spice turmeric, possesses diverse pharmacologic effects including anti-inflammatory, anti-oxidant, anti-proliferative and anti-angiogenic activities. accumulating experimental evidence suggests that curcumin interferes with a variety of molecular targets and processes involved in cancer. further, data obtained in multiple preclinical models, as well as in preliminary clinical trials, have documented minimal toxicity of curcumin, even at ... | 2009 | 19496751 |
| polyphenols in the prevention and treatment of sepsis syndromes: rationale and pre-clinical evidence. | sepsis is the overwhelming systemic response to infection of a normally sterile body compartment. despite advances in elucidating its pathophysiology, severe sepsis remains a leading cause of death in the critically ill. polyphenols are a family of chemicals found in food and beverages derived from plants, such as cocoa, green tea, turmeric, and soya, as well as in medicinal herbs. these phytochemicals exhibit anti-inflammatory and vasculoprotective properties in clinical and preclinical studies ... | 2009 | 19502006 |
| clinical development of novel proteasome inhibitors for cancer treatment. | emerging evidence demonstrates that targeting the tumor proteasome is a promising strategy for cancer therapy. | 2009 | 19505187 |
| curcumin induces apoptosis through fas and fadd, in caspase-3-dependent and -independent pathways in the n18 mouse-rat hybrid retina ganglion cells. | curcumin, a naturally occurring yellow pigment isolated from turmeric, is a well known antioxidant with broad spectrum of anti-tumor activities against many human cancer cells. in this study, curcumin-induced cytotoxic effect of mouse-rat hybrid retina ganglion cells (n18) were investigated. for determining cell viability, the trypan blue exclusion and flow cytometric analysis were used. the curcumin-caused cell cycle arrest in n18 cells was examined by flow cytometry. curcumin affect on the pro ... | 2009 | 19513510 |
| curcumin has bright prospects for the treatment of inflammatory bowel disease. | inflammatory bowel disease (ibd) is a chronic relapsing-remitting condition that afflicts millions of people throughout the world and impairs their daily functions and quality of life. while the aetiology of ibd is not understood well, it appears to be driven by inflammatory cytokines such as tumor necrosis factor (tnf)-alpha. hence, there is a strong interest in agents that can block the generation or actions of inflammatory cytokines. curcumin is a bioactive substance present in the rhizomes o ... | 2009 | 19519446 |
| preparation and characterization of zedoary turmeric oil-loaded insulin-modified sterically stabilized liposomes. | the poor selectivity of anticancer drugs often leads to their multiplicate dose-limiting toxicities in humans, which severely restricts their clinical application. in this study, a novel liposomal formulation of zedoary turmeric oil (zto) targeting the insulin receptor (ir) was prepared by covalently conjugating insulin to the terminal of the polyethylene glycol (peg) chain of sterically stabilized liposomes. in vitro assays indicated that a higher uptake of insulin-modified sterically stabilize ... | 2010 | 19522660 |
| curcumin inhibits cell proliferation of mda-mb-231 and bt-483 breast cancer cells mediated by down-regulation of nfkappab, cyclind and mmp-1 transcription. | curcumin, an active constituent of turmeric, has been shown to possess inhibitory effect of cell proliferation and induction of apoptosis towards a board range of tumors. cell inhibition activities of curcumin are behaved differently in various cell types. to investigate the mechanism basis for the cell inhibition of curcumin on breast cancer cell lines, we examine curcumin effect on nfkappab, cell cycle regulatory proteins and matrix metalloproteinases (mmps) in two breast cancer cell lines (md ... | 2009 | 19524420 |
| [effect of different seminal rhizomes on yield and quality of curcuma longa]. | to study the effect of different seminal rhizomes on the growth, quality and quantity of curcuma longa root. | 2009 | 19526779 |
| determination of minimum effective dose and optimal dosing schedule for liposomal curcumin in a xenograft human pancreatic cancer model. | curcumin is a food chemical present in tumeric (curcuma longa) that has pharmacological activity to suppress carcinogenesis and inhibits multiple signaling pathways such as nuclear factor kappab (nf-kappab), cyclooxygenase-2 (cox-2) and interleukin-8 (il-8). oral curcumin has poor oral bioavailability limiting its clinical activity; however, a patent pending liposomal formulation of curcumin was developed to improve drug delivery and has demonstrated activity in multiple cancers. this study was ... | 2009 | 19528445 |
| direct analysis of curcumin in turmeric by dart-ms. | the new ion source technique, direct analysis in real time (dart) atmospheric pressure ionisation, allows high resolution mass measurements of gas, liquid and solid samples. as dart-ms produces [m + h](+) molecular ions of most compounds, relatively simple and clear mass spectra are obtained even of multi-component samples. in order to take advantage of the capacity of dart-ms for the real time analysis of individual compounds in natural raw materials, a pilot study was performed using the well- ... | 2016 | 19533593 |
| photostability of natural orange-red and yellow fungal pigments in liquid food model systems. | the variation in the photostability among the currently authorized natural pigments limits their application span to a certain type of food system, and more robust alternatives are being sought after to overcome this problem. in the present study, the photostability of an orange-red and a yellow fungal pigment extract produced by ascomycetous fungi belonging to the genera penicillium and epicoccum , respectively, were studied in a soft drink model medium and in citrate buffer at low and neutral ... | 2009 | 19534525 |
| purification and characterization of a approximately 34 kda antioxidant protein (beta-turmerin) from turmeric (curcuma longa) waste grits. | beta-turmerin from turmeric (curcuma longa) waste grits obtained after extraction of curcumin was purified by successive gel permeation chromatography. homogeneity of beta-turmerin was confirmed by its movement as single band both in sds-page and as well as in native (basic) page. the apparent molecular mass is approximately 34 kda by sds-page. it is more hydrophobic protein and showed sharp single peak in rp-hplc with retention time of 62.17 min. it is a glycoprotein as it shows the presence of ... | 2009 | 19539010 |
| amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of il-17 production. | experimental autoimmune encephalomylitis (eae), an animal mode of multiple sclerosis (ms), was previously considered that be mediated by th1 cells. however, a number of recent studies provided strong evidence that t helper cells that produce il-17 play a dominant role in the pathogenesis of eae. curcumin (1,7-bis 94-hydroxy-3-methoxyphenyl)-1,6 heptadiene-3, 5-di-one) is a naturally occurring polyphenolic phytochemical isolated from the rhizome of the medicinal plant curcuma longa. it has been s ... | 2009 | 19539560 |
| curcumin improves vascular function and alleviates oxidative stress in non-lethal lipopolysaccharide-induced endotoxaemia in mice. | oxidative stress is implicated in various pathological conditions, including septic shock, and other diseases associated with local or systemic inflammation. curcumin, a major component from turmeric (curcuma longa), possesses diverse anti-inflammatory, anti-tumour and antioxidant properties. the aim of this study was to investigate the effect of curcumin on modulation of vascular dysfunction and oxidative stress induced by lipopolysaccharide (lps) in mice. male icr mice were treated with curcum ... | 2009 | 19540224 |
| curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress. | chronic stress occurs in everyday life and induces impaired spatial cognition, neuroendocrine and plasticity abnormalities. a potential therapeutic for these stress related disturbances is curcumin, derived from the curry spice turmeric. previously we demonstrated that curcumin reversed the chronic stress-induced behavioral deficits in escape from an aversive stimulus, however the mechanism behind its beneficial effects on stress-induced learning defects and associated pathologies are unknown. t ... | 2009 | 19540859 |
| new curcumin analogues exhibit enhanced growth-suppressive activity and inhibit akt and signal transducer and activator of transcription 3 phosphorylation in breast and prostate cancer cells. | curcumin, the active component of turmeric, has been shown to protect against carcinogenesis and prevent tumor development in cancer. to enhance its potency, we tested the efficacy of synthetic curcumin analogues, known as flll11 and flll12, in cancer cells. we examined the impact of flll11 and flll12 on cell viability in eight different breast and prostate cancer cell lines. flll11 and flll12 (ic(50) values 0.3-5.7 and 0.3-3.8 micromol/l, respectively) were substantially more potent than curcum ... | 2009 | 19558577 |
| structure elucidation and nmr assignments for curcuminoids from the rhizomes of curcuma longa. | thirteen curcuminoids (1-13) were isolated from the rhizomes of curcuma longa. among them, 1,5-dihydroxy-1,7-bis(4-hydroxyphenyl)-4,6-heptadiene-3-one (1), 1,5-dihydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-4,6-heptadiene-3-one (2), 1,5-dihydroxy-1-(4-hydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-4,6-heptadiene-3-one (3), and 3-hydroxy-1,7-bis-(4-hydroxyphenyl)-6-heptene-1,5-dione (4) are new compounds, and 1-(4-hydroxyphenyl)-7-(3, 4-dihydroxyphenyl)-1, 6-heptadiene-3, 5-dione (5) i ... | 2009 | 19569074 |
| determining the adulteration of spices with sudan i-ii-ii-iv dyes by uv-visible spectroscopy and multivariate classification techniques. | we propose a very simple and fast method for detecting sudan dyes (i, ii, iii and iv) in commercial spices, based on characterizing samples through their uv-visible spectra and using multivariate classification techniques to establish classification rules. we applied three classification techniques: k-nearest neighbour (knn), soft independent modelling of class analogy (simca) and partial least squares discriminant analysis (pls-da). a total of 27 commercial spice samples (turmeric, curry, hot p ... | 2009 | 19576460 |
| effects of a turmeric extract (curcuma longa) on chronic ultraviolet b irradiation-induced skin damage in melanin-possessing hairless mice. | turmeric (the rhizomes of curcuma longa l., zingiberacease) is widely used as a dietary pigment and spice, and has been traditionally used for the treatment of inflammation, skin wounds and hepatic disorders in ayurvedic, unani and chinese medicine. although the topical application or oral administration of turmeric is used to improve skin trouble, there is no evidence to support this effect. the aim of this study was to clarify whether turmeric prevents chronic ultraviolet b (uvb)-irradiated sk ... | 2009 | 19577913 |
| curcumin derivatives: molecular basis of their anti-cancer activity. | curcumin, a phenolic compound from the plant curcuma longa l., has shown a wide-spectrum of chemopreventive, antioxidant and antitumor properties. although its promising chemotherapeutic activity, preclinical and clinical studies highlight curcumin limited therapeutic application due to its instability in physiological conditions. to improve its stability and activity, many derivatives have been synthesized and studied, among which bis-demethoxycurcumin (bdmc) and diacetylcurcumin (dac). in this ... | 2009 | 19580791 |
| curcumin and cancer cells: how many ways can curry kill tumor cells selectively? | cancer is a hyperproliferative disorder that is usually treated by chemotherapeutic agents that are toxic not only to tumor cells but also to normal cells, so these agents produce major side effects. in addition, these agents are highly expensive and thus not affordable for most. moreover, such agents cannot be used for cancer prevention. traditional medicines are generally free of the deleterious side effects and usually inexpensive. curcumin, a component of turmeric (curcuma longa), is one suc ... | 2009 | 19590964 |
| anti-inflammatory properties of curcumin, a major constituent of curcuma longa: a review of preclinical and clinical research. | curcuma longa (turmeric) has a long history of use in ayurvedic medicine as a treatment for inflammatory conditions. turmeric constituents include the three curcuminoids: curcumin (diferuloylmethane; the primary constituent and the one responsible for its vibrant yellow color), demethoxycurcumin, and bisdemethoxycurcumin, as well as volatile oils (tumerone, atlantone, and zingiberone), sugars, proteins, and resins. while numerous pharmacological activities, including antioxidant and antimicrobia ... | 2009 | 19594223 |
| curcumin suppresses expression of low-density lipoprotein (ldl) receptor, leading to the inhibition of ldl-induced activation of hepatic stellate cells. | obesity is often accompanied by hypercholesterolemia characterized by elevated levels of plasma low-density lipoprotein (ldl) and associated with non-alcoholic steatohepatitis, which could progress to hepatic fibrosis. hepatic stellate cells (hscs) are the major effectors of hepatic fibrogenesis. this study aims to clarify effects of ldl on activation of hsc, to evaluate roles of curcumin in suppressing these effects and to further elucidate the underlying molecular mechanisms. experimental appr ... | 2009 | 19594758 |
| protective effect of curcumin (curcuma longa), against aluminium toxicity: possible behavioral and biochemical alterations in rats. | aluminium is a potent neurotoxin and has been associated with alzheimer's disease (ad) causality for decades. prolonged aluminium exposure induces oxidative stress and increases amyloid beta levels in vivo. current treatment modalities for ad provide only symptomatic relief thus necessitating the development of new drugs with fewer side effects. the aim of the study was to demonstrate the protective effect of chronic curcumin administration against aluminium-induced cognitive dysfunction and oxi ... | 2009 | 19616038 |
| innate immune response and disease resistance in carassius auratus by triherbal solvent extracts. | this study reports the effect of aqueous, ethanol and methanol triherbal solvent extract from azadirachta indica, ocimum sanctum and curcuma longa on innate immune mechanisms such as phagocytosis activity, respiratory burst activity, alternative complement activity and lysozyme activity and disease resistance in goldfish (carassius auratus) against aeromonas hydrophila. fish were intraperitoneally injected with different doses of 0, 5, 50 and 100 mg kg(-1) body weight of each triherbal solvent e ... | 2009 | 19616631 |
| identification and characterization of multiple curcumin synthases from the herb curcuma longa. | curcuminoids are pharmaceutically important compounds isolated from the herb curcuma longa. two additional type iii polyketide synthases, named curs2 and curs3, that are capable of curcuminoid synthesis were identified and characterized. in vitro analysis revealed that curs2 preferred feruloyl-coa as a starter substrate and curs3 preferred both feruloyl-coa and p-coumaroyl-coa. these results suggested that curs2 synthesizes curcumin or demethoxycurcumin and curs3 synthesizes curcumin, bisdemetho ... | 2009 | 19622354 |
| curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin d1, cox-2, mmp-9, vegf and cxcr4 expression in an orthotopic mouse model. | because of the poor prognosis and the development of resistance against chemotherapeutic drugs, the current treatment for advanced metastatic colorectal cancer (crc) is ineffective. whether curcumin (a component of turmeric) can potentiate the effect of capecitabine against growth and metastasis of crc was investigated. the effect of curcumin on proliferation of crc cell lines was examined by mitochondrial dye-uptake assay, apoptosis by esterase staining, nuclear factor-kappab (nf-kappab) by ele ... | 2009 | 19623659 |
| curcumin delays development of medroxyprogesterone acetate-accelerated 7,12-dimethylbenz[a]anthracene-induced mammary tumors. | combined hormone therapy (ht) containing estrogen and progestin (medroxyprogesterone acetate [mpa]) leads to increased risk of breast cancer in postmenopausal women, compared with ht regimens containing estrogen alone or placebo. we previously reported that in animal models, progestins can accelerate the development of mammary tumors by increasing vascular endothelial growth factor (vegf) levels. we furthermore showed that curcumin, an indian spice derived from the turmeric root, specifically in ... | 2010 | 19629015 |
| turmeric reduces inflammatory cells in hamster opisthorchiasis. | the curcumin compound from turmeric is effective in the treatment of many inflammatory diseases. the aim of our present study was to evaluate the efficacy of turmeric on reducing the histopathological changes of hamster opisthorchiasis. hamsters were infected with opisthorchis viverrini and then administered turmeric. using light microscopic observation, liver function tests for alanine transaminase (alt), alkaline phosphatase, and direct bilirubin were investigated. the resulting histopathologi ... | 2009 | 19633869 |
| surface-enhanced raman spectroscopy: a direct method to identify colorants in various artist media. | surface-enhanced raman spectroscopy (sers) has been developed as a direct, extractionless, nonhydrolysis tool to detect lake pigments and colorants of various classes used in a variety of artist materials. presented first is the sers analysis of the natural colorant turmeric (curcuma longa l.), main component curcumin, as present in dry lake pigment grains, dyed textile yarns, and reference paint layers containing the lake pigment bound in animal glue painted on glass. this experiment demonstrat ... | 2009 | 19637904 |
| curcumin is not a ligand for peroxisome proliferator-activated receptor-γ | curcumin, a compound found in the spice turmeric, has been shown to possess a number of beneficial biological activities exerted through a variety of different mechanisms. some curcumin effects have been reported to involve activation of the nuclear transcription factor peroxisome proliferator-activated receptor-γ (ppar-γ), but the concept that curcumin might be a ppar-γ ligand remains controversial. results reported here demonstrate that, in contrast to the ppar-γ ligands ciglitazone and rosigl ... | 2009 | 19644570 |
| curcumin inhibits acth- and angiotensin ii-stimulated cortisol secretion and ca(v)3.2 current. | adrenocorticotropic hormone and angiotensin ii stimulate cortisol secretion from bovine adrenal zona fasciculata cells by the activation of adenylate cyclase and phospholipase c-coupled receptors. curcumin (1- 20 mum), a compound found in the spice turmeric, inhibited cortisol secretion stimulated by acth, angii, and 8cpt-camp. curcumin also suppressed acth-stimulated increases in mrnas coding for steroid acute regulatory protein and cyp11a1 steroid hydroxylase. in whole cell patch clamp recordi ... | 2009 | 19653644 |
| neuroinflammation in alzheimer's disease: different molecular targets and potential therapeutic agents including curcumin. | alzheimer's disease (ad) is a neurodegenerative disorder of the elderly. deposition of amyloid beta plaque and associated neuroinflammation are the major hallmarks of ad. whereas reactive oxygen species (ros) and activated microglial cells contribute to neuronal loss, nuclear factor kappab and apolipoprotein e participate in inflammatory process of ad. current fda approved drugs provide only symptomatic relief in ad. for broad spectrum of activity, some natural products are also being tested. tu ... | 2009 | 19656726 |
| curcumin enhances paraquat-induced apoptosis of n27 mesencephalic cells via the generation of reactive oxygen species. | curcumin, the active compound of the rhizome of curcuma longa has anti-inflammatory, antioxidant and antiproliferative activities. this agent has been shown to regulate numerous transcription factors, cytokines, protein kinases, adhesion molecules, redox status and enzymes that have been linked to inflammation. while curcumin has been identified as an activator of apoptosis in several cell lines, the mechanism by which it initiates apoptosis, however, remains poorly understood. we considered cur ... | 2009 | 19660496 |
| curcumin inhibits proliferation of colorectal carcinoma by modulating akt/mtor signaling. | curcumin, a natural polyphenol product of the plant curcuma longa, has been shown to inhibit the growth and progression of colorectal cancer; however, the anticancer mechanism of curcumin remains to be elucidated. | 2009 | 19661333 |
| curcumin activates ampk and suppresses gluconeogenic gene expression in hepatoma cells. | curcumin, the bioactive component of curry spice turmeric, and its related structures possess potent anti-oxidant and anti-inflammatory properties. several lines of evidence suggest that curcumin may play a beneficial role in animal models of diabetes, both by lowering blood glucose levels and by ameliorating the long-term complications of diabetes. however, current understanding of the mechanism of curcumin action is rudimentary and is limited to its anti-oxidant and anti-inflammatory effects. ... | 2009 | 19665995 |
| curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of bcl-2 and survivin expression and akt signaling. | new cytotoxic agents are urgently needed for the treatment of advanced ovarian cancer because of the poor long-term response of this disease to conventional chemotherapy. curcumin, obtained from the rhizome of curcuma longa, has potent anticancer activity; however, the mechanism of curcumin-induced cytotoxicity in ovarian cancer cells remains a mystery. in this study we show that curcumin exhibited time- and dose-dependent cytotoxicity against monolayer cultures of ovarian carcinoma cell lines w ... | 2010 | 19676105 |
| antioxidant efficacy of curcuminoids from turmeric ( curcuma longa l.) powder in broiler chickens fed diets containing aflatoxin b1. | a 3-week-feeding study (1-21 d post-hatch) was conducted to evaluate the efficacy of total curcuminoids (tcmn), as an antioxidant, to ameliorate the adverse effects of aflatoxin b1 (afb1) in broiler chickens. turmeric powder (curcuma longa l.) that contained 2.55 % tcmn was used as a source of tcmn. six cage replicates of five chicks each were assigned to each of six dietary treatments, which included: basal diet; basal diet supplemented with 444 mg/kg tcmn; basal diet supplemented with 1.0 mg/k ... | 2009 | 19682401 |
| curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers. | little progress has been made in the last three decades in the treatment of bladder cancer. novel agents that are nontoxic and can improve the current standard of care of this disease are urgently needed. curcumin, a component of curcuma longa (also called turmeric), is one such agent that has been shown to suppress pathways linked to oncogenesis, including cell survival, proliferation, invasion and angiogenesis. we investigated whether curcumin has potential to improve the current therapy for b ... | 2010 | 19682434 |
| the potential role of curcumin (diferuloylmethane) in plasma cell dyscrasias/paraproteinemia. | plasma cell dyscrasias, most commonly associated with paraproteinemia, are a diverse group of diseases. monoclonal gammopathy of undefined significance (mgus) can precede multiple myeloma, a progressive neoplastic disease. mgus occurs in association with a variety of other diseases and currently no treatment is recommended but rather "watchful waiting". given that the size of the m-protein is a risk factor for disease progression, early intervention with the aim of reducing the paraprotein load ... | 2008 | 19707439 |
| possibility of fighting food borne bacteria by egyptian folk medicinal herbs and spices extracts. | phytotherapy (herbal medicine) have a long-standing history in egypt. current study investigated the antimicrobial potentialities of twenty five herbs and spices which are widely used in folk medicine by egyptian housewives to treat gastrointestinal disorders against seven bacterial strains, mostly food borne including pathogens. they were tested by using paper disc diffusion technique as qualitative assay and agar dilution method for determining the minimum inhibitory concentration (mic) of her ... | 2009 | 19712651 |
| optimized turmeric extracts have potent anti-amyloidogenic effects. | inhibition of beta-amyloid (a beta) accumulation and a beta fibril (fa beta) formation from a beta are attractive therapeutic targets for the treatment of alzheimer's disease (ad). while previous studies have shown anti-amyloidogenic effects of curcumin in vitro and in vivo, no studies have examined optimized turmeric extracts enriched in curcuminoids or turmerones. three standardized turmeric extracts, hss-838, hss-848, and hss-888, were prepared with different chemical profiles to investigate ... | 2009 | 19715544 |
| uncoupling of oxidative phosphorylation by curcumin: implication of its cellular mechanism of action. | curcumin is a phytochemical isolated from the rhizome of turmeric. recent reports have shown curcumin to have antioxidant, anti-inflammatory and anti-tumor properties as well as affecting the 5'-amp activated protein kinase (ampk), mtor and stat-3 signaling pathways. we provide evidence that curcumin acts as an uncoupler. well-established biochemical techniques were performed on isolated rat liver mitochondria in measuring oxygen consumption, f(0)f(1)-atpase activity and atp biosynthesis. curcum ... | 2009 | 19715674 |
| plant-derived health: the effects of turmeric and curcuminoids. | plants contain numerous polyphenols, which have been shown to reduce inflammation and hereby to increase resistance to disease. examples of such polyphenols are isothiocyanates in cabbage and broccoli, epigallocatechin in green tee, capsaicin in chili peppers, chalones, rutin and naringenin in apples, resveratrol in red wine and fresh peanuts and curcumin/curcuminoids in turmeric. most diseases are maintained by a sustained discreet but obvious increased systemic inflammation. many studies sugge ... | 2013 | 19721899 |
| interleukin-1beta-induced extracellular matrix degradation and glycosaminoglycan release is inhibited by curcumin in an explant model of cartilage inflammation. | osteoarthritis (oa) is a degenerative and inflammatory disease of synovial joints that is characterized by the loss of articular cartilage, for which there is increasing interest in natural remedies. curcumin (diferuloylmethane) is the main polyphenol in the spice turmeric, derived from rhizomes of the plant curcuma longa. curcumin has potent chemopreventive properties and has been shown to inhibit nuclear factor kappab-mediated inflammatory signaling in many cell types, including chondrocytes. ... | 2009 | 19723086 |
| effect of curcumin on nuclear factor kappab signaling pathways in human chronic myelogenous k562 leukemia cells. | curcumin, a natural product isolated from the plant curcuma longa, has a diverse range of molecular targets that influence numerous biochemical and molecular cascades. curcumin has been shown to inhibit nuclear factor kappab (nf-kappab) activation at several steps in the nf-kappab signaling pathways and thereby controls numerous nf-kappab-regulated genes involved in various diseases. in the present study, we investigated the effect of curcumin pretreatment on 84 tumor necrosis factor-alpha (tnf- ... | 2009 | 19723087 |