Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| possible nitric oxide modulation in protective effect of (curcuma longa, zingiberaceae) against sleep deprivation-induced behavioral alterations and oxidative damage in mice. | sleep is essential for the physical and mental health of a human being. problems of sleep deprivation are increasing in modern society nowadays. recently, various antioxidants have been implicated as neuroprotectants in the treatment of stress and stress related problems. the present study was designed to explore the possible role of nitric oxide in the protective effect of curcumin (curcuma longa, zingiberaceae) against 72-h sleep deprivation-induced behavioral alterations and oxidative damage ... | 2008 | 18586477 |
| [study on growth and dry substance accumulation of curcuma longa]. | to explore the growth characteristics of curcuma longa, and provide basis for standardized cultivation. | 2008 | 18590184 |
| curcumin or saikosaponin a improves hepatic antioxidant capacity and protects against ccl4-induced liver injury in rats. | curcumin and saikosaponin a, the bioactive phytochemicals of turmeric and bupleurum, act as antioxidants. this study investigated the effects of supplementation with curcumin and/or saikosaponin a on hepatic lipids and antioxidant status in rats with ccl(4)-induced liver injury. male sprague-dawley rats were randomly divided into control, ccl(4), ccl(4) + curcumin (0.005%; cu), ccl(4) + saikosaponin a (0.004%; ss), and ccl(4) + curcumin + saikosaponin a (0.005% + 0.004%; cu+ss) groups. ccl(4) (4 ... | 2008 | 18598162 |
| bisacurone inhibits adhesion of inflammatory monocytes or cancer cells to endothelial cells through down-regulation of vcam-1 expression. | bisacurone, one of the active compounds of the traditionally used indigenous herb curcuma longa linne (zingiberaceae), has anti-oxidant, anti-inflammatory, and anti-metastatic activities. we studied how the level of vascular cell adhesion molecule-1 (vcam-1), one of the key molecules in the development of atherosclerosis as well as carcinogenesis and metastasis, might be affected by bisacurone in tumor necrosis factor-alpha (tnf-alpha)-activated human umbilical vein endothelial cells (huvecs). b ... | 2008 | 18602074 |
| the biosynthetic pathway of curcuminoid in turmeric (curcuma longa) as revealed by 13c-labeled precursors. | in order to investigate the biosynthesis of curcuminoid in rhizomes of turmeric (curcuma longa), we established an in vitro culture system of turmeric plants for feeding (13)c-labeled precursors. analyses of labeled desmethoxycurcumin (dmc), an unsymmetrical curcuminoid, by (13)c-nmr, revealed that one molecule of acetic acid or malonic acid and two molecules of phenylalanine or phenylpropanoids, but not tyrosine, were incorporated into dmc. the incorporation efficiencies of the same precursors ... | 2008 | 18603793 |
| dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat. | curcumin (diferuloylmethane), an active ingredient of turmeric, obtained from the powdered rhizomes of curcuma longa linn., has been traditionally recognized for treatment of several diseases. to evaluate the potential clinical use of curcumin, we determined the dose dependence of its effects in the therapeutic window and of the neuroprotective efficacy in a cerebral thromboembolic model of the rat. rats were subjected to occlusion of the middle cerebral artery (mcao) by a thrombus and treated w ... | 2008 | 18611416 |
| potential of spice-derived phytochemicals for cancer prevention. | although spices have been used for thousands of years and are known for their flavor, taste and color in the food, they are not usually recognized for their medicinal value. extensive research within the last two decades from our laboratory and others has indicated that there are phytochemicals present in spices that may prevent various chronic illnesses including cancerous, diabetic, cardiovascular, pulmonary, neurological and autoimmune diseases. for instance, the potential of turmeric (curcum ... | 2008 | 18612945 |
| calebin-a induces apoptosis and modulates mapk family activity in drug resistant human gastric cancer cells. | this study is the first to investigate calebin-a, a natural compound present in curcuma longa, which inhibits cell growth and induce apoptosis in sgc7901/vincristine cells, a multidrug resistant (mdr) human gastric adenocarcinoma cell line. our data suggest the drug efflux function of p-glycoprotein was inhibited by calebin-a treatment, while the expression level of p-glycoprotein was not affected. additionally, co-treatment of calebin-a and vincristine resulted in a remarkable reduction in s ph ... | 2008 | 18619958 |
| review article: new drug formulations, chemical entities and therapeutic approaches for the management of ulcerative colitis. | treatment options for ulcerative colitis (uc) are expanding with the development of novel drug formulations and dosing regimens and new chemical entities. although the goals of medical therapy for uc remain unchanged, that is to induce and to maintain remission, focus has also centred on improving patient compliance, modifying the natural course of disease and healing the mucosa. | 2008 | 18627362 |
| [analytical method for carbamate pesticides in processed foods by lc/ms/ms]. | a rapid analytical method for the simultaneous determination of carbamate pesticides in processed foods was established by liquid chromatography coupled with tandem mass spectrometry (lc/ms/ms). the pesticides were extracted from samples with acetonitrile using accelerated solvent extract equipment, except for the fine powder type spices, which were extracted in an ultrasonic bath. the crude extract was cleaned up with a multi-solvent gpc column (shodex asahipak gf-310 hq) using acetonitrile as ... | 2008 | 18633196 |
| curcumin prevents human dendritic cell response to immune stimulants. | curcumin, a compound found in the indian spice turmeric, has anti-inflammatory and immunomodulatory properties, though the mechanism remains unclear. dendritic cells (dcs) are important to generating an immune response and the effect of curcumin on human dcs has not been explored. the role curcumin in the dc response to bacterial and viral infection was investigated in vitro using lps and poly i:c as models of infection. cd14(+) monocytes, isolated from human peripheral blood, were cultured in g ... | 2008 | 18639521 |
| synergistic effects of multiple natural products in pancreatic cancer cells. | pancreatic cancer (pc) remains the fourth most common cause of cancer related death in the united states. therefore, novel strategies for the prevention and treatment are urgently needed. numerous dietary and pharmacological agents have been proposed as alternative strategies for the prevention and/or treatment of pc. isoflavone is a prominent flavonoid found in soy products and has been proposed to be responsible for lowering the incidence of pc in asians. similarly, curcumin, an active ingredi ... | 2008 | 18640131 |
| evaluation of widely consumed botanicals as immunological adjuvants. | many widely used botanical medicines are claimed to be immune enhancers. clear evidence of augmentation of immune responses in vivo is lacking in most cases. to select botanicals for further study based on immune enhancing activity, we study them here mixed with antigen and injected subcutaneously (s.c.). globo h and gd3 are cell surface carbohydrates expressed on glycolipids or glycoproteins on the cell surface of many cancers. when conjugated to keyhole limpet hemocyanin (klh), mixed with an i ... | 2008 | 18640165 |
| inhibitory effects of spices and herbs on iron availability. | spices and herbs are extensively used in indigenous diets in tropical regions where prevalence of iron deficiency is still high. they are rich in polyphenolic compounds that are expected to inhibit iron absorption by forming iron complexes in the intestine, making dietary iron less available for absorption. the effects of six spices and herbs (chili pepper, garlic, 'pak kyheng' (thai leafy vegetable), shallot, tamarind, turmeric) and one mixture of spices (curry paste) on iron availability were ... | 2009 | 18651292 |
| new mechanisms and therapeutic potential of curcumin for colorectal cancer. | curcumin is a polyphenol derived from curcuma longa. over the last few years, a number of studies have provided evidence of its main pharmacological properties including chemosensitizing, radiosensitizing, wound healing activities, antimicrobial, antiviral, antifungical, immunomodulatory, antioxidant and anti-inflammatory. more recent data provide interesting insights into the effect of this compound on cancer chemoprevention and chemotherapy. in fact, preclinical studies have shown its ability ... | 2008 | 18655004 |
| curcumin has anticonvulsant activity on increasing current electroshock seizures in mice. | epilepsy is one of the most common serious disorders of the brain. several experimental studies have reported neuroprotective and antioxidant activity of certain natural products like curcumin, an active ingredient of turmeric. the present study was designed to explore the effect of acute administration of curcumin at doses 50, 100 and 200 mg/kg, orally (p.o.) and its chronic (x 21 days) administration in 100 mg/kg, p.o. on increasing current electroshock (ices) test, elevated plus maze and acto ... | 2008 | 18661468 |
| [study on extracting process for tiao zhian mixture]. | to study the technology of optimal extraction for tiao zhian mixture. | 2008 | 18661837 |
| potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. | although safe in most cases, ancient treatments are ignored because neither their active component nor their molecular targets are well defined. this is not the case, however, with curcumin, a yellow-pigment substance and component of turmeric (curcuma longa), which was identified more than a century ago. for centuries it has been known that turmeric exhibits anti-inflammatory activity, but extensive research performed within the past two decades has shown that this activity of turmeric is due t ... | 2009 | 18662800 |
| potential of resveratrol in anticancer and anti-inflammatory therapy. | phytochemicals present in food have shown significant prospects in the treatment and management of a vast array of human diseases. resveratrol is a stilbene-type aromatic phytoalexin predominantly found in grapes, peanuts, berries, turmeric, and other food products. resveratrol has been reported to exhibit several physiological activities including anticancer and anti-inflammatory activities in vitro and in experimental animal models, as well as in humans. anticancer activity of this compound is ... | 2008 | 18667005 |
| anti-inflammatory ingredients. | there is a growing public awareness and concern among individuals regarding the condition of their skin, with a concomitant desire to use natural products to treat skin conditions. the increased interest in these products has spurred scientific and clinical studies evaluating the composition and clinical usefulness of natural products in the treatment of inflammatory skin dermatoses. there are numerous natural ingredients that have been demonstrated to possess anti-inflammatory properties that m ... | 2008 | 18681154 |
| ef24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits hif-1. | curcumin, the yellow pigment of the spice turmeric, has emerged as a promising anticancer agent due to its antiproliferative and antiangiogenic properties. however, the molecular mechanism of action of this compound remains a subject of debate. in addition, curcumin's low bioavailability and efficacy profile in vivo further hinders its clinical development. this study focuses on the mechanism of action of ef24, a novel curcumin analog with greater than curcumin biological activity and bioavailab ... | 2008 | 18682687 |
| application of scion image software to the simultaneous determination of curcuminoids in turmeric (curcuma longa). | curcumin, desmethoxycurcumin and bisdesmethoxycurcumin are bioactive constituents of turmeric (curcuma longa). owing to their different potency, quality control of turmeric based on the content of each curcuminoid is more reliable than that based on total curcuminoids. however, to perform such an assay, high-cost instrument is needed. | 2009 | 18683171 |
| dietary turmeric modulates dmba-induced p21ras, map kinases and ap-1/nf-kappab pathway to alter cellular responses during hamster buccal pouch carcinogenesis. | the chemopreventive efficacy of turmeric has been established in experimental systems. however, its mechanism(s) of action are not fully elucidated in vivo. the present study investigates the mechanism of turmeric-mediated chemoprevention in 7,12-dimethylbenz(a)anthracene (dmba)-induced hamster buccal pouch (hbp) carcinogenesis at 2, 4, 6, 10 and 12 weeks. dietary turmeric (1%) led to decrease in dmba-induced tumor burden and multiplicity, and enhanced the latency period in parallel, to its modu ... | 2008 | 18687351 |
| differential effects of curcumin on cryopreserved versus fresh primary human hepatocytes. | curcumin (cur) is a major component of a dietary spice derived from the roots of curcuma longa. it has strong antioxidant activities and hepatoprotective properties. primary human hepatocytes are clinically used in transplantation or in bioartificial liver devices for the treatment of patients with liver failure. fresh and cryopreserved hepatocytes are also used in vitro for the study of drugs in pharmacotoxicology. we aimed to assess whether cur could improve human liver cell viability and prev ... | 2008 | 18697189 |
| curcumin inhibits osteoclastogenesis by decreasing receptor activator of nuclear factor-kappab ligand (rankl) in bone marrow stromal cells. | curcumin (diferuloylmethane), a pigment derived from turmeric, has anti-oxidant and anti-inflammatory activities. accumulating evidence points to a biochemical link between increased oxidative stress and reduced bone density. osteoclast formation was evaluated in co-cultures of bone marrow stromal cells (bmsc) and whole bone marrow cells (bmc). expression of receptor activator of nuclear factor-kappab ligand (rankl) was analyzed at the mrna and protein levels. exposure to curcumin led to dose-de ... | 2008 | 18719352 |
| androgen responsive and refractory prostate cancer cells exhibit distinct curcumin regulated transcriptome. | curcumin (diferuloylmethane) is the major active component of turmeric and is being actively investigated for its anti-cancer properties. to better understand the biological mechanisms of the chemopreventive potential of curcumin in prostate cancer, we have evaluated curcumin regulated transcriptome in prostate cancer cells. hierarchical clustering methods and functional classification of the curcumin-gene expression response (cu-ger) showed temporal co-regulation of genes involved in oxidative ... | 2008 | 18719366 |
| prevention of hepatotoxicity due to anti tuberculosis treatment: a novel integrative approach. | to evaluate the ability of curcuma longa (cl) and tinospora cordifolia (tc) formulation to prevent anti-tuberculosis (tb) treatment (att) induced hepatotoxicity. | 2008 | 18720535 |
| qualitative and quantitative analysis of four species of curcuma rhizomes using twice development thin layer chromatography. | the rhizomes of curcuma phaeocaulis, curcuma kwangsiensis, curcuma wenyujin and curcuma longa are used as ezhu or jianghuang in traditional chinese medicine for a long time. due to their similar morphological characters, it is difficult to distinguish their origins of raw materials used in clinic. in this study, a simple, rapid and reliable twice development tlc method was developed for qualitative and quantitative analysis of the four species of curcuma rhizomes. the chromatography was performe ... | 2008 | 18722068 |
| influence of food acidulants and antioxidant spices on the bioaccessibility of beta-carotene from selected vegetables. | four common food acidulants--amchur, lime, tamarind, and kokum--and two antioxidant spices--turmeric and onion--were examined for their influence on the bioaccessibility of beta-carotene from two fleshy and two leafy vegetables. amchur and lime generally enhanced the bioaccessibility of beta-carotene from these test vegetables in many instances. such an improved bioaccessibility was evident in both raw and heat-processed vegetables. the effect of lime juice was generally more pronounced than tha ... | 2008 | 18729454 |
| modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells. | apoptosis is a highly regulated mechanism by which cells undergo cell death in an active way. as one of the most challenging tasks concerning cancer is to induce apoptosis in malignant cells, researchers increasingly focus on natural products to modulate apoptotic signaling pathways. curcumin, a natural compound isolated from the plant curcuma longa, has chemopreventive properties, which are mainly due to its ability to arrest cell cycle and to induce apoptosis. this article reviews the main eff ... | 2008 | 18755156 |
| antidepressant activity of curcumin: involvement of serotonin and dopamine system. | curcumin is a major active principle of curcuma longa, one of the widely used preparations in the indian system of medicine. it is known for its diverse biological actions. | 2008 | 18766332 |
| curcumin diminishes human osteoclastogenesis by inhibition of the signalosome-associated i kappab kinase. | curcumin is a natural polyphenolic derogate extracted from spice turmeric, exhibiting anti-inflammatory and chemopreventive activities. it was described to interact with the signalosome-associated kinases and the proteasome-ubiquitin system, which both are involved in the osteoclastogenesis. thus, we hypothesized that curcumin could diminish osteoclast differentiation and function. | 2009 | 18766375 |
| quantitation of curcuminoids in curcuma rhizome by near-infrared spectroscopic analysis. | this study investigated a nondestructive and rapid quantitation method for the curcuminoids, including curcumin, demethoxycurcumin, and bisdemethoxycurcumin, present in turmeric using near-infrared (nir) spectroscopy and multivariate statistics. in the second derivatives of the nir spectra of turmeric samples, two characteristic absorptions of curcuminoids were detected around 1700 and 2300-2320 nm. partial least-squares regression (pls-r) analysis was applied to the nir spectra obtained from 34 ... | 2008 | 18767866 |
| biological activities of curcumin and its analogues (congeners) made by man and mother nature. | curcumin, a yellow pigment present in the indian spice turmeric (associated with curry powder), has been linked with suppression of inflammation; angiogenesis; tumorigenesis; diabetes; diseases of the cardiovascular, pulmonary, and neurological systems, of skin, and of liver; loss of bone and muscle; depression; chronic fatigue; and neuropathic pain. the utility of curcumin is limited by its color, lack of water solubility, and relatively low in vivo bioavailability. because of the multiple ther ... | 2008 | 18775680 |
| in vivo effects of pain relieving plaster on closed soft tissue injury in rabbit ears. | soft tissue injury imposes major public health burdens worldwide. the positive effect of china's tibetan medicine and the lamiophlomis rotata-based herbal pain relieving plaster (prp) on healing closed soft tissue injury (csti) has been reported. the herbs contained in plaster are also referred as 'blood-activating and stasis-dispelling' in herbal medicine. the formula of the plaster contains four china's tibetan medical herbs, including lamiophlomis rotata, oxytropis falcate bunge, curcuma long ... | 2008 | 18793392 |
| curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo. | curcumin (diferuloylmethane) is the major active ingredient of turmeric (curcuma longa) used in south asian cuisine for centuries. curcumin has been shown to inhibit the growth of transformed cells and to have a number of potential molecular targets. however, the essential molecular targets of curcumin under physiologic conditions have not been completely defined. herein, we report that the tumor cellular proteasome is most likely an important target of curcumin. nucleophilic susceptibility and ... | 2008 | 18794115 |
| curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor hlj1. | curcumin (diferuloylmethane) is an active component of the spice turmeric and has a diversity of antitumor activities. in this study, we found that curcumin can inhibit cancer cell invasion and metastasis through activation of the tumor suppressor dnaj-like heat shock protein 40 (hlj1). human lung adenocarcinoma cells (cl1-5) treated with curcumin (1-20 mumol/l) showed a concentration-dependent reduction in cell migration, invasion, and metastatic ability, and this was associated with increased ... | 2008 | 18794131 |
| the effect of curcumin (active substance of turmeric) on the acetic acid-induced visceral nociception in rats. | in the present study, the effect of chronic oral administration of curcumin in the presence or absence of morphine and noloxone was investigated on the visceral nociception induced by acetic acid in rats. intraperitoneal injection of acetic acid (1 ml, 2%) produced contractions in the abdominal musculature (writhes). the latency time to the beginning of the first writhe was measured and the total number of writhes in the 1 h after acetic acid injection was counted. the latency time to the beginn ... | 2008 | 18817212 |
| alkaloid and sesquiterpenes from the root tuber of curcuma longa. | one new quinoline alkaloid and seven known bisabolane sesquiterpenes: 2-(2'-methyl-1'-propenyl)-4, 6-dimethyl-7-hydroxyquinoline (1), 2, 5-dihydroxybisabola-3, 10-diene (2), 4, 5-dihydroxybisabola-2,10-diene (3), turmeronol a (4), bisacurone (5), bisacurone a (6), bisacurone b (7) , bisacurone c (8), as well as dehydrozingerone (9) and zingerone (10) were isolated from the root tuber of curcuma longa. their structures were identified by spectral evidence. compound 1 is a new compound, compounds ... | 2008 | 18819476 |
| purification of curcumin, demethoxycurcumin, and bisdemethoxycurcumin by high-speed countercurrent chromatography. | curcuminoids are substances of great interest because of their important pharmacological activities, particularly anti-inflammatory, anticarcinogenic, and anti-alzheimer's activities. in this study, we report the first procedure and effect of processing for the high, efficient, and useful purification of curcumin, demethoxycurcumin, and bisdemethoxycurcumin from turmeric powder. purification involves high-speed countercurrent chromatographic (hsccc) separation of these curcuminoids using a simpl ... | 2008 | 18826228 |
| neuroprotective efficacy and therapeutic window of curcuma oil: in rat embolic stroke model. | among the naturally occurring compounds, turmeric from the dried rhizome of the plant curcuma longa has long been used extensively as a condiment and a household remedy all over southeast asia. turmeric contains essential oil, yellow pigments (curcuminoids), starch and oleoresin. the present study was designed for investigating the neuroprotective efficacy and the time window for effective therapeutic use of curcuma oil (c. oil). | 2008 | 18826584 |
| comparison of inhibitory potency of three different curcuminoid pigments on nitric oxide and tumor necrosis factor production of rat primary microglia induced by lipopolysaccharide. | microglia are the resident innate immune cells in the central nervous system. evidence supports that the unregulated activation of microglia results in the production of pro-inflammatory cytokines and chemokines that propagate neuronal injury and finally cause neurodegenerative diseases. curcuminn (cur), demethoxycurcumin (dmc), and bisdemethoxycurcumin (bdmc) are curcuminoid pigments extracted from turmeric (curcuma longa l.). cur has been reported to suppress the activation of microglia by red ... | 2008 | 18838107 |
| survey of heavy metal pollution in four chinese crude drugs and their cultivated soils. | a two-year survey on the residues of heavy metals in four chinese crude drugs and their cultivated soils was conducted. targeted heavy metals were copper (cu), arsenic (as), lead (pb), nickel (ni), and cadmium (cd). herbs surveyed include white peony root (radix paeoniae alba), turmeric root tuber (radix curcumae), thunberg fritillary bulb (bulbus fritillariae thumbergii), and tuber of dwarf lilyturf (radix ophiopogonis). concentrations of all heavy metals were under the permitted levels except ... | 2008 | 18839045 |
| anti-inflammatory activity of curcumin in macrophages stimulated by lipopolysaccharides from porphyromonas gingivalis. | porphyromonas gingivalis, a major periodontopathic bacterium, is necessary for periodontitis to take place. the lipopolysaccharide (lps) of p. gingivalis stimulates cytokine secretion in immune cells, and thereby initiates the inflammation related to periodontitis. macrophages are the important ones of the immune cells that are prominent at inflammatory periodontal sites. curcumin, a major curcumanoid found in the spice turmeric, exhibits anti-inflammatory properties. the aim of this study was t ... | 2008 | 18849645 |
| screening of korean medicinal plants for possible osteoclastogenesis effects in vitro. | bone undergoes continuous remodeling through bone formation and resorption, and maintaining the balance for skeletal rigidity. bone resorption and loss are generally attributed to osteoclasts. differentiation of osteoclasts is regulated by receptor activator of nuclear factor nf-kb ligand (rankl), a member of tumor necrosis factor family. when the balance is disturbed, pathological bone abnormality ensues. through the screening of traditional korean medicinal plants, the effective molecules for ... | 2008 | 18850234 |
| curcumin suppresses constitutive activation of nuclear factor-kappa b and requires functional bax to induce apoptosis in burkitt's lymphoma cell lines. | we provide evidence that curcumin, a natural compound isolated from rhizomes of plant curcuma longa, induces apoptosis in several burkitt's lymphoma cell lines expressing bax protein (as283a, kk124, and pa682pb), whereas it has no effects in cell lines with no bax expression (bml895 and ca46). our data show that curcumin treatment results in down-regulation of constitutive activation of nuclear factor-kappab (nf-kappab) via generation of reactive oxygen species where it causes conformational cha ... | 2008 | 18852135 |
| histological evaluation of curcuma longa-ghee formulation and hyaluronic acid on gingival healing in dog. | the experimental finding of asian traditional medicine revealed the pharmacological effect of the local application of ghee which was taken from cow butterfat and the rhizomes of curcuma longa. these materials significantly improved the healing process of the wound. in addition, ancient physicians of middle east discovered that the powdered rhizomes of curcuma longa (common turmeric) also had impressive medicinal qualities. over the centuries, this spice has been used as a pain relieving, anti-i ... | 2008 | 18929638 |
| inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in alzheimer's disease. | curcuminoids (a mixture of curcumin, bisdemethoxycurcumin and demethoxycurcumin) share vital pharmacological properties possessed by turmeric, a well known curry spice, considered useful in alzheimer's disease (ad). the aim of this study was to evaluate if curcuminoids possess acetylcholinesterase (ache) inhibitory and memory enhancing activities. the in-vitro and ex-vivo models of ache inhibitory activity were used along with morris water maze test to study the effect on memory in rats. curcumi ... | 2009 | 18930076 |
| in vitro and in vivo studies of the use of some medicinal herbals against the pathogen aeromonas hydrophila in goldfish. | aeromonas hydrophila is a ubiquitous and opportunistic bacterial pathogen that produces ulcerative dermatitis under stress conditions and inflicts severe losses on global fisheries and fish culture. this study evaluates the antimicrobial potency of aqueous and ethanolic decoction (individual extract) and concoction (mixed extract) of three common medicinal herbs, turmeric curcuma longa, tulsi plant ocimum sanctum, and neem azadirachta indica, against the in vitro growth of a. hydrophila. among t ... | 2008 | 18942593 |
| standardization of the ayurvedic formulation haridra khanda using high-performance thin-layer chromatography-densitometry. | the present study aimed to standardize the ayurvedic preparation haridra khanda containing curcuma longa as a major ingredient. various physicochemical parameters such as alcohol-soluble extractive, water-soluble extractive, total ash, and acid-insoluble ash were determined according to the ayurvedic pharmacopoeia of india. microscopic evaluation of the formulation revealed the presence of various diagnostic cell structures of c. longa. trace metal analysis indicated the absence of toxic metals ... | 2013 | 18980135 |
| demethoxycurcumin and its semisynthetic analogues as antitubercular agents. | demethoxycurcumin, isolated from the rhizomes of curcuma longa, was found to possess antitubercular activity against mycobacterium tuberculosis h (37)rv strain at 200 microg/ml. derivatisation of this active principle yielded a potent agent 6, exhibiting considerable activity with a minimum inhibitory concentration (mic) value of 7.8 microg/ml. h (37)rv:mycobacterium tuberculosis h (37)rv strain mic:minimum inhibitory concentration. | 2008 | 18991209 |
| anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes. | curcumin, a yellow pigment extracted from rhizomes of the plant curcuma longa (turmeric), has been widely used as food additive and also as a herbal medicine throughout asia. the present study was designed to study the pharmacological, biochemical and neurochemical effects of daily administration of curcumin to rats subjected to chronic unpredictable stress. curcumin treatment (20 and 40 mg/kg, i.p., 21 days) significantly reversed the chronic unpredictable stress-induced behavioral (increase im ... | 2009 | 19000708 |
| natural derivatives of curcumin attenuate the wnt/beta-catenin pathway through down-regulation of the transcriptional coactivator p300. | curcumin, a component of turmeric (curcuma longa), has been reported to suppress beta-catenin response transcription (crt), which is aberrantly activated in colorectal cancer. however, the effects of its natural analogs (demethoxycurcumin [dmc] and bisdemethoxycurcumin [bdmc]) and metabolite (tetrahydrocurcumin [thc]) on the wnt/beta-catenin pathway have not been investigated. here, we show that dmc and bdmc suppressed crt that was activated by wnt3a conditioned-medium (wnt3a-cm) without alterin ... | 2008 | 19000900 |
| inhibitory effect of curcumin on the invasion of rat ascites hepatoma cells in vitro and ex vivo. | curcumin, a yellow pigment in turmeric, is a food factor withantioxidative activity. the effect of curcumin on the proliferation and invasion of the rat ascites hepatoma ah109acells was studied in vitro and ex vivo assay systems. especially, a co-culture system of the hepatoma cellswith mesothelial cells derived from rat mesentery was employed to investigate the invasive motility. curcumin suppressed thehepatoma slipping motility in a dose-dependent manner up to 5 mum and thereafter maintained t ... | 2001 | 19003281 |
| curcumin attenuates acrylamide-induced cytotoxicity and genotoxicity in hepg2 cells by ros scavenging. | acrylamide (aa), a proven rodent carcinogen, has recently been discovered in foods heated at high temperatures. this finding raises public health concerns. in our previous study, we found that aa caused dna fragments and increase of reactive oxygen species (ros) formation and induced genotoxicity and weak cytotoxicity in hepg2 cells. presently, curcumin, a natural antioxidant compound present in turmeric was evaluated for its protective effects. the results showed that curcumin at the concentrat ... | 2008 | 19012407 |
| an ethnobotanical study of medicinal plants in chandauli district of uttar pradesh, india. | chandauli district is one of the less studied regions of india for its ethnobotanical values. the present paper synthesizes the first report related to the documentation and conservation of ethnomedicinal plants of chandauli district and their socio-economic relationship with the forests and its resources. | 2009 | 19022368 |
| curcumin and muscle wasting: a new role for an old drug? | sepsis, severe injury, and cancer are associated with loss of muscle mass. muscle wasting in these conditions is mainly caused by increased proteolysis, at least in part regulated by nuclear factor-kappab. despite recent progress in the understanding of mediators and mechanisms involved in muscle wasting, effective and universally accepted treatments by which muscle atrophy can be prevented or reversed are still lacking. we review recent evidence suggesting that curcumin (diferuloylmethane), a c ... | 2009 | 19028079 |
| curcuminoids modulates oxidative damage and mitochondrial dysfunction in diabetic rat brain. | diabetes exacerbates neuronal injury induced by hyperglycemia mediated oxidative damage and mitochondrial dysfunction. the aim of the present study is to investigate the effects of curcuminoids, polyphenols of curcuma longa (l.) on oxidative stress and mitochondrial impairment in the brain of streptozotocin (stz)-induced diabetic rats. a marked increase in lipid peroxidation and nitrite levels with simultaneous decrease in endogenous antioxidant marker enzymes was observed in the diabetic rat br ... | 2008 | 19031318 |
| effect of dietary turmeric on breath hydrogen. | turmeric is widely used in indian cuisine. the main constituents of turmeric are curcumin and its analogues, which are well-known antioxidant compounds. in the present study, we hypothesized that turmeric in curry might increase bowel motility and activate hydrogen-producing bacterial flora in the colon, thereby increasing the concentration of breath hydrogen. eight healthy subjects fasted for 12 h and ingested curry and rice with or without turmeric (turmeric knockout curry). breath-hydrogen co ... | 2009 | 19034660 |
| inhibition of human dendritic cell activation by hydroethanolic but not lipophilic extracts of turmeric (curcuma longa). | turmeric has been extensively utilized in indian and chinese medicine for its immune-modulatory properties. dendritic cells (dcs) are antigen-presenting cells specialized to initiate and regulate immunity. the ability of dcs to initiate immunity is linked to their activation status. the effects of turmeric on human dcs have not been studied. here we show that hydroethanolic (hee) but not lipophilic "supercritical" extraction (sce) of turmeric inhibits the activation of human dcs in response to i ... | 2009 | 19034830 |
| curcumin in combination with visible light inhibits tumor growth in a xenograft tumor model. | it is known that curcumin, a dietary pigment from the plant curcuma longa, inhibits cell proliferation and induces apoptosis in different cell lines; however, the therapeutic benefit is hampered by very low absorption after transdermal or oral application. recent studies from our laboratory have demonstrated that curcumin at low concentrations (0.2-1 microg/ml) offered the described effects only when applied with uva or visible light. nevertheless, the in vivo efficacy of this combination is lac ... | 2009 | 19035461 |
| treatment of hiv-associated diarrhea with curcumin. | curcumin is the organic extract of turmeric and possesses known anti-inflammatory properties. our aim was to explore the utility of curcumin in patients with hiv-associated diarrhea. eight patients with hiv-associated diarrhea were given a mean daily dose of 1,862 mg of curcumin and followed for a mean of 41 weeks. all had resolution of diarrhea and normalization of stool quality in a mean time of 13 +/- 9.3 days. mean number of bowel movements per day dropped from 7 +/- 3.6 to 1.7 +/- 0.5. seve ... | 2009 | 19051018 |
| developing curcumin into a viable therapeutic for lymphoma. | emerging evidence suggests that natural plant ingredients have played an important role in the healthcare of many countries. several of these natural plant products possess therapeutic potential for various diseases including cancer. curcumin is the pigment of turmeric, a well-known chemopreventive agent that has been shown to suppress the proliferation of a wide variety of tumor cells, including lymphoma. curcumin has been shown to have cancer chemopreventive potential against a variety of tumo ... | 2009 | 19053882 |
| newborn umbilical cord and skin care in sylhet district, bangladesh: implications for the promotion of umbilical cord cleansing with topical chlorhexidine. | newborn cord care practices may directly contribute to infections, which account for a large proportion of the four million annual global neonatal deaths. this formative research study assessed current umbilical and skin care knowledge and practices for neonates in sylhet district, bangladesh, in preparation for a cluster-randomized trial of the impact of topical chlorhexidine cord cleansing on neonatal mortality and omphalitis. unstructured interviews (n=60), structured observations (n=20), rat ... | 2008 | 19057570 |
| curcumin-induced recovery from hepatic injury involves induction of apoptosis of activated hepatic stellate cells. | hepatic stellate cells (hscs) undergo activation and transdifferentiation to myofibroblast like cells in liver injury, leading to liver fibrosis. during recovery from injury, activated hscs may either revert back to quiescent state or undergo apoptosis or both. in the present study, we have examined whether recovery from hepatic injury involves apoptosis of activated hscs and tested whether curcumin (the yellow pigment from curcuma longa linn.) promotes recovery from hepatic injury by inducing a ... | 2008 | 19069843 |
| modules of co-regulated metabolites in turmeric (curcuma longa) rhizome suggest the existence of biosynthetic modules in plant specialized metabolism. | turmeric is an excellent example of a plant that produces large numbers of metabolites from diverse metabolic pathways or networks. it is hypothesized that these metabolic pathways or networks contain biosynthetic modules, which lead to the formation of metabolite modules-groups of metabolites whose production is co-regulated and biosynthetically linked. to test whether such co-regulated metabolite modules do exist in this plant, metabolic profiling analysis was performed on turmeric rhizome sam ... | 2009 | 19073964 |
| curcumin suppresses the induction of indoleamine 2,3-dioxygenase by blocking the janus-activated kinase-protein kinase cdelta-stat1 signaling pathway in interferon-gamma-stimulated murine dendritic cells. | indoleamine 2,3-dioxygenase (ido) catalyzes the initial and rate-limiting step in the degradation of tryptophan and is strongly induced in interferon-gamma (ifngamma)-stimulated dendritic cells (dcs). ido has recently been established as a key enzyme in t-cell suppression-mediated immune tolerance to tumors. stat1 phosphorylation appears to play an important role in the control of ido expression by ifngamma, but the precise regulatory mechanism remains obscure. here we present a novel mechanism ... | 2009 | 19075017 |
| immune defects in alzheimer's disease: new medications development. | alzheimer's disease (ad) is a neurodegenerative disease characterized by the accumulation of intracellular and extracellular aggregates. according to the amyloid beta (abeta) hypothesis, amyloidosis occurring in the brain is a leading cause of neurodegeneration in ad. defects in the innate immune system may decrease the clearance of abeta in the brain. macrophages of most ad patients do not transport abeta into endosomes and lysosomes, and monocytes from ad patients do not efficiently clear abet ... | 2008 | 19090986 |
| [comparison and correlative analysis of trace elements in five kinds of radix curcumae]. | traditional chinese medicine materials (tcm) contained abundant trace elements needed in human body. mixed acid (hno3:hclo4) was added into samples treated by microwave digestion, and a systematic study was carried out by selection of the most appropriate working conditions and optimization of the sample mass. some inorganic elements in 5 kinds of radix curcumae (curcuma wenyujin y. h. chen et c. ling, curcuma longa l., curcuma kwangsiensis s. g. lee et c. f. liang, curcuma phaeocaulis val. and ... | 2008 | 19093592 |
| pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. | curcumin (diferuloylmethane), a yellow pigment in the spice turmeric (also called curry powder), has been used for centuries as a treatment for inflammatory diseases. extensive research within the past two decades has shown that curcumin mediates its anti-inflammatory effects through the downregulation of inflammatory transcription factors (such as nuclear factor kappab), enzymes (such as cyclooxygenase 2 and 5 lipoxygenase) and cytokines (such as tumor necrosis factor, interleukin 1 and interle ... | 2009 | 19110321 |
| curcuminoid-phospholipid complex induces apoptosis in mammary epithelial cells by stat-3 signaling. | curcumin (from the rhizome of curcuma longa) is well documented for its medicinal properties in indian and chinese systems of medicine where it is widely used for the treatment of several diseases. epidemiological observations are suggestive that curcumin consumption may reduce the risk of some form of cancers and provide other protective biological effects in humans. these biological properties have been attributed to curcuminoids that have been widely studied for their anti-inflammatory, anti- ... | 2008 | 19116450 |
| involvement of na(+)-ca (2+) exchanger in the endothelium-independent vasorelaxation induced by curcuma longa l. in isolated rat superior mesenteric arteries. | previous studies confirmed that the methanolic extract from curcuma longa l. (clme) lowers arterial blood pressure and heart rate in rats due to the blockade of extracellular ca(2+) influx. the aim of this study was to investigate the involvement of na(+)-ca (2+) exchanger in the vasorelaxant effects elicited by clme in isolated rat superior mesenteric arteries. clme (1-1,000 microg/ml) concentration-dependently relaxed phenylephrine (phe) (10 microm) pre-contracted arterial rings with intact-en ... | 2008 | 19122379 |
| curcuma zedoaria rosc. (white turmeric): a review of its chemical, pharmacological and ethnomedicinal properties. | curcuma zedoaria rosc is a perennial herb found in tropical countries, such as india, japan and thailand. various parts of this plant are used in ayurveda and other folk medicines for the treatment of different ailments such as diarrhoea, cancer, flatulence and dyspepsia. this study is an attempt to compile an up-to-date and comprehensive review of c. zedoaria that covers its traditional and folk medicinal uses, phytochemistry and pharmacology. | 2009 | 19126292 |
| epidemiology of animal bites and rabies cases in india. a multicentric study. | rabies, a disease of antiquity continues to be a major public health problem in india. multiple factors contribute to high mortality and morbidity due to animal bites. an effective strategy for control of rabies takes into account the epidemiology of animal bites, rabies and factors influencing post exposure treatment. the study was carried out as a part of agreement for performance of work (apw) from world health organization (who) during the period april 2001 to september 2002. two sets of pro ... | 2008 | 19127666 |
| molecular orbital basis for yellow curry spice curcumin's prevention of alzheimer's disease. | it is demonstrated by using high-level ab initio computations that the yellow curcumin pigment, bis-(4-hydroxy-3-methoxyphenyl)-1,6-diene-3,5-dione, in the east indian root plant turmeric (curcuma longa) exhibits unique charge and bonding characteristics that facilitate penetration into the blood-brain barrier and binding to amyloid beta (abeta). alzheimer's disease is caused by abeta accumulation in the brain cells combined with oxidative stress and inflammation. consistent with the recent expe ... | 2006 | 19127718 |
| a poly-herbal formulation accelerates normal and impaired diabetic wound healing. | in the present study, a poly-herbal formulation (phf) was prepared by combining the aqueous lyophilized leaf extracts of hippophae rhamnoides l. and aloe vera l. and the ethanol rhizome extract of curcuma longa l., in an optimized ratio (1 : 7 : 1). the efficacy of phf treatment was studied in normal and impaired diabetic rats using a full-thickness cutaneous wound model. topical phf treatment increased cellular proliferation and collagen synthesis at the wound site in normal rats, as evidenced ... | 2008 | 19128249 |
| modulation of ovine neutrophil function and apoptosis by standardized extracts of echinacea angustifolia, butea frondosa and curcuma longa. | impaired neutrophil function has been associated with increased infectious diseases in ruminants. attachment of neutrophils to endothelium and superoxide production is critical features of their immune activity. once the infection is cleared, programmed cell death ensures the rapid resolution of inflammation. to develop new natural therapeutics for ruminants, standard extracts of echinacea angustifolia (polinacea), butea frondosa and curcuma longa (curcuvet) were first evaluated on ovine neutrop ... | 2009 | 19128841 |
| study of curcumin and genistein interactions with human serum albumin. | curcumin, the yellow pigment from the rhizoma of curcuma longa, is a widely studied polyphenolic compound which has a variety of biological activity as anti-inflammatory and antioxidative agent. genistein one of the flavonoids found in soybean and chickpeas inhibits dna strand breaks acting as a direct scavenger of reactive oxygen species. human serum albumin (hsa) with high affinity binding sites is a major transporter for delivering several endogenous compounds and drugs in vivo. the aim of th ... | 2009 | 19135819 |
| curcumin inhibition of integrin (alpha6beta4)-dependent breast cancer cell motility and invasion. | curcumin, a polyphenol natural product isolated from the rhizome of the plant curcuma longa, has emerged as a promising anticancer therapeutic agent. however, the mechanism by which curcumin inhibits cancer cell functions such as cell growth, survival, and cell motility is largely unknown. we explored whether curcumin affects the function of integrin alpha(6)beta(4), a laminin adhesion receptor with an established role in invasion and migration of cancer cells. here we show that curcumin signifi ... | 2008 | 19138983 |
| potential effect of curcuma longa extract on infectivity and pathogenicity of schistosoma mansoni cercariae. | batch of freshly shed cercariae from infected laboratory bred biomphalaria alexandrina were exposed to different sub-lethal concentrations of turmeric extract for an hour and divided into two groups. the first one was to study the ultrastructural changes induced in them using scanning electron microscopy (sem). the second group was to study infectivity and pathogenicity of the exposed cercariae. one hundred and fifty mice were divided into 5 groups: gi: infected by normal cercariae and served as ... | 2008 | 19143127 |
| study on antifibrotic effects of curcumin in rat hepatic stellate cells. | suppression of activation or fibrogenesis and induction of apoptosis, in hepatic stellate cells (hscs) have been proposed as therapeutic strategies against liver fibrosis. curcumin, an active compound isolated from yellow curry pigment of turmeric (curcuma longa linn), has been demonstrated to be an effective anti-inflammatory and antioxidant compound. in this study, we investigated the in vitro antifibrogenic effects of curcumin on hscs at the concentration range of (1-40 microm). a cell line o ... | 2009 | 19152370 |
| currying the heart: curcumin and cardioprotection. | curcumin (diferuoylmethane) is the active ingredient of turmeric (curcuma longa). there has been a surge of research in its anti-inflammatory and antioxidative properties, and its cardiovascular effects. a host of studies in in vitro and in vivo models of cardiac injury show that curcumin treatment reduces reactive oxygen species generation, monocyte adhesion to activated endothelial cells, and phosphorylation of c-jun n-terminal kinase, p38 mitogen activated protein kinase and signal transducer ... | 2009 | 19153099 |
| curcumin attenuates oxidative damage in animals treated with a renal carcinogen, ferric nitrilotriacetate (fe-nta): implications for cancer prevention. | curcumin (diferuloylmethane), a biologically active ingredient derived from rhizome of the plant curcuma longa, has potent anticancer properties as demonstrated in a plethora of human cancer cell lines/animal carcinogenesis model and also acts as a biological response modifier in various disorders. we have reported previously that dietary supplementation of curcumin suppresses renal ornithine decarboxylase (okazaki et al. biochim biophys acta 1740:357-366, 2005) and enhances activities of antiox ... | 2009 | 19165575 |
| curcumin attenuates elastase- and cigarette smoke-induced pulmonary emphysema in mice. | curcumin, a yellow pigment obtained from turmeric (curcumina longa), is a dietary polyphenol that has been reported to possess anti-inflammatory and antioxidant properties. the effect of curcumin against the development of pulmonary emphysema in animal models is unknown. the aim of this study was to determine whether curcumin is able to attenuate the development of pulmonary emphysema in mice. nine-week-old male c57bl/6j mice were treated with intratracheal porcine pancreatic elastase (ppe) or e ... | 2009 | 19168576 |
| antioxidative effects of curcumin and its analogues against the free-radical-induced peroxidation of linoleic acid in micelles. | curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, 1) is a yellow ingredient isolated from turmeric (curcumin longa). many health benefits have been claimed for curcumin, and these have generally been ascribed to its radical-trapping antioxidant properties. in order to find more active antioxidants with 1 as the lead compound, we synthesized curcumin analogues, i.e., 1,7-bis(3,4-dihydroxyphenyl)-1,6-heptadiene-3,5-dione (2), 1-(3,4-dihydroxyphenyl)-7-(4-hydroxy-3-methoxypheny ... | 2009 | 19173279 |
| curcumin disrupts the mammalian target of rapamycin-raptor complex. | curcumin (diferuloylmethane), a polyphenol natural product of the plant curcuma longa, is undergoing early clinical trials as a novel anticancer agent. however, the anticancer mechanism of curcumin remains to be elucidated. recently, we have shown that curcumin inhibits phosphorylation of p70 s6 kinase 1 (s6k1) and eukaryotic initiation factor 4e (eif4e) binding protein 1 (4e-bp1), two downstream effector molecules of the mammalian target of rapamycin complex 1 (mtorc1) in numerous cancer cell l ... | 2009 | 19176385 |
| effects of curcumin on n-bis(2-hydroxypropyl) nitrosamine (dhpn)-induced lung and liver tumorigenesis in balb/c mice in vivo. | curcumin (diferuloylmethane), a phenolic compound from the plant curcuma longa (linn.) has been shown to exhibit antitumor activity and apoptosis in many human cancer cell lines including that of lung and liver cancer. in this study, curcumin was evaluated in balb/c mice for its ability to inhibit pulmonary and liver adenoma formation and growth after they were orally treated with n-bis(2-hydroxypropyl)nitrosamine (dhpn). animals were treated with dhpn in water for approximately 14 days before m ... | 2008 | 19181006 |
| interaction of tea catechin (-)-epigallocatechin gallate with lipid bilayers. | a major component of green tea extracts, catechin (-)-epigallocatechin gallate (egcg), has been reported to be biologically active and interacting with membranes. a recent study reported drastic effects of egcg on giant unilamellar vesicles (guvs). in particular, egcg above 30 microm caused guvs to burst. here we investigated the effect of egcg on single guvs at lower concentrations, believing that its molecular mechanism would be more clearly revealed. we used the micropipette aspiration method ... | 2009 | 19186140 |
| comparative antiulcer effect of bisdemethoxycurcumin and curcumin in a gastric ulcer model system. | the antiulcer effect of bisdemethoxycurcumin, a yellow pigment found mainly in rhizomes of curcuma longa, was compared with curcumin in gastric ulcer model systems to validate its clinical application as a remedy for peptic ulcer. western blot analysis of mouse macrophage cell line raw 264.7 activated with lipopolysaccharide showed that bisdemethoxycurcumin inhibited inducible nitric oxide synthase (inos) production significantly but had no effect on tumor necrosis factor-alpha (tnf-alpha) produ ... | 2009 | 19188055 |
| molecular mechanism of curcumin induced cytotoxicity in human cervical carcinoma cells. | cervical cancer is the most common cancer in indian females and is associated with infection with high risk human papillomaviruses (hpvs). curcumin (diferuloyl methane), a chemopreventive agent, is a natural compound extracted from curcuma longa that allows suppression of carcinogenesis. the objective of this study was to identify the molecular mechanism of curcumin induced apoptosis in hpv positive cervical cancer hela, siha and ca ski cells. curcumin causes distinct inhibition of human telomer ... | 2009 | 19191010 |
| botanical phenolics and brain health. | the high demand for molecular oxygen, the enrichment of polyunsaturated fatty acids in membrane phospholipids, and the relatively low abundance of antioxidant defense enzymes are factors rendering cells in the central nervous system (cns) particularly vulnerable to oxidative stress. excess production of reactive oxygen species (ros) in the brain has been implicated as a common underlying factor for the etiology of a number of neurodegenerative diseases, including alzheimer's disease (ad), parkin ... | 2008 | 19191039 |
| novel artemisinin and curcumin micellar formulations: drug solubility studies by nmr spectroscopy. | artemisinin, a potent antimalarial drug derived from artemisia annua l., and curcumin, a polyphenol extracted from the roots of curcuma longa l., are reported to exert a synergistic antimalarial action, albeit manifesting a low bioavailability. in fact, both these molecules are poorly soluble in aqueous environments. in this study, we report a dosy investigation of the solubilisation capacity of micelles of sodium dodecyl sulphate (sds) for artemisinin and curcumin, individually and in combinati ... | 2009 | 19199296 |
| a simple 2-directional high-performance thin-layer chromatographic method for the simultaneous determination of curcumin, metanil yellow, and sudan dyes in turmeric, chili, and curry powders. | a method using simple extraction and 2-directional high-performance thin-layer chromatography (hptlc) was developed for the simultaneous determination of curcumin, metanil yellow, and sudan dyes in turmeric, chili, and various mixed curry powder formulations. the method offers resolution (rf) of turmeric pigments, namely, curcumin (0.77), demethoxycurcumin (0.69), bis(demethoxy)curcumin (0.61), and the synthetic dye metanil yellow (0.05) by the first-directional mobile phase, chloroform-methanol ... | 2008 | 19202799 |
| antimicrobial activity of curcumin against helicobacter pylori isolates from india and during infections in mice. | treatment failure is a major cause of concern for the helicobacter pylori-related gastroduodenal diseases like gastritis, peptic ulcer, and gastric cancer. curcumin, diferuloylmethane from turmeric, has recently been shown to arrest h. pylori growth. the antibacterial activity of curcumin against 65 clinical isolates of h. pylori in vitro and during protection against h. pylori infection in vivo was examined. the mic of curcumin ranges from 5 microg/ml to 50 microg/ml, showing its effectiveness ... | 2009 | 19204190 |
| two methods for attenuating toxoplasma gondii tachyzoites rh strain by using ethanol extract of curcuma longa. | the ethanol extract of curcuma longa proved to be an attenuated agent against toxoplasma gondii (rh strain) tachyzoites in the mice peritoneal fluid by two incubation methods. groups of female mice were injected by attenuated tachyzoites as 200 tachyzoites / ml, which treated with the ethanol extract of curcuma longa was previously treated. the result was observed after one week, as no tachyzoites were found in the peritoneal fluid of the experimental infected mice. | 2008 | 19209778 |
| turmeric and green tea: a recipe for the treatment of b-chronic lymphocytic leukemia. | two naturally occurring compounds, curcumin, the active ingredient in the spice turmeric, and the green tea extract epigallocatechin-3-gallate, have marked effects on the apoptotic machinery in chronic lymphocytic leukemia. these results provide a preclinical foundation for future clinical use of these compounds in this disease. | 2009 | 19228716 |
| curcumin inhibits prosurvival pathways in chronic lymphocytic leukemia b cells and may overcome their stromal protection in combination with egcg. | chronic lymphocytic leukemia (cll) is incurable with current chemotherapy treatments. curcumin (diferuloylmethane), an active ingredient in the spice turmeric, inhibits tumor metastasis, invasion, and angiogenesis in tumor cell lines. we evaluated the effects of curcumin on the viability of primary cll b cells and its ability to overcome stromal mediated protection. | 2009 | 19228728 |
| the protective role of curcumin in cardiovascular diseases. | curcumin (diferuloylmethane) is a polyphenol responsible for the yellow color of the curry spice turmeric. it has been used in a variety of diseases in traditional medicine. modern scientific research has demonstrated its anti-inflammatory, anti-oxidant, anti-carcinogenic, anti-thrombotic, and cardiovascular protective effects. in this review, we focused mainly on the effects of curcumin on the cardiovascular system. the antioxidant effects of curcumin have been shown to attenuate adriamycin-ind ... | 2009 | 19233493 |
| inhibition of lps-induced production of inflammatory factors in the macrophages by mono-carbonyl analogues of curcumin. | curcumin (diferuloylmethane) is an orange-yellow compound from turmeric (curcuma longa), a spice found in curry powder. traditionally known for its anti-inflammatory effects, curcumin has established itself in the last two decades to be a potent immunomodulatory agent that can regulate the activation of a variety of immunocytes and the expression of inflammatory factors. considering that the beta-diketone moiety of curcumin may result in its instability and poor metabolic property, we previously ... | 2009 | 19243473 |
| immunomodulatory effects of curcumin treatment on murine schistosomiasis mansoni. | curcumin is a polyphenol derived from the dietary spice turmeric. it has been shown to regulate numerous transcription factors, cytokines, adhesion molecules, and enzymes that have been linked to inflammation. in addition to inhibiting the growth of a variety of pathogens, curcumin has been shown to have nematocidal activity. the present study was designed to evaluate the schistosomicidal activity of curcumin in vivo as well as immunomodulation of granulomatous inflammation and liver pathology i ... | 2009 | 19249123 |