Publications

photodynamic inactivation of paracoccidioides brasiliensis helps the outcome of oral paracoccidiodomycosis.	the antifungal drug therapy often employed to treat paracoccidiodomycosis (pcm), an important neglected fungal systemic infection, leads to offensive adverse effects, besides being very long-lasting. in addition, pcm compromises the oral health of patients by leading to oral lesions that are very painful and disabling. in that way, photodynamic therapy (pdt) arises as a new promising adjuvant treatment for inactivating paracoccidioides brasiliensis (pb), the responsible fungus for pcm, and also ...	2017	28349345
anti-apoptotic effects of decyl gallate on the induction of apoptosis in a549 pneumocytes by paracoccidioides brasiliensis gp43.	apoptosis is considered an escape mechanism from the host immune system for the fungus paracoccidioides spp, and it serves as a vehicle for entry into macrophages without stimulating microbicidal activities. recently, gp43 of p. brasiliensis was demonstrated to be involved in this process. therefore, as a new therapeutic alternative, it is very important to study compounds that could reduce the modulation of the induction of apoptosis caused by this fungus. decyl gallate (g14) is a known antifun ...	2017	28339963
animal models and antifungal agents in paracoccidioidomycosis: an overview.	paracoccidioides brasiliensis is the etiologic agent of paracoccidioidomycosis, the most prevalent systemic mycosis in latin america. the morbidity and mortality associated with paracoccidioidomycosis necessitate our understanding of fungal pathogenesis and discovering of new agents to treat this infection. animal models have contributed much to the knowledge of fungal infections and their corresponding therapeutic treatments. this is true for animal models of the primary fungal pathogens such a ...	2017	28324244
miltefosine is fungicidal to paracoccidioides spp. yeast cells but subinhibitory concentrations induce melanisation.	paracoccidioidomycosis (pcm) is a systemic mycosis caused by the dimorphic fungi paracoccidioides spp. the duration of antifungal treatment ranges from months to years and relapses may nevertheless occur despite protracted therapy. thus, there remains an urgent need for new therapeutic options. miltefosine (mlt), an analogue of alkylphospholipids, has antifungal activity against species of yeast and filamentous fungi. the aim of this study was to evaluate the antifungal effects of mlt on the yea ...	2017	28279786
standardization and validation of dot-elisa assay for paracoccidioides brasiliensis antibody detection.	paracoccidioidomycosis (pcm) is a neglected systemic mycosis caused by a dimorphic fungus of the paracoccidioides genus. the standard diagnosis is based on isolation of the fungi in culture, and by microscopic visualization of characteristic multiple budding yeast cells in biological samples. however, in some situations, access to the site of injury prevents the collection of biological material. a variety of immuno-serological techniques has proven useful for allowing inferring diagnosis with a ...	2017	28239394
effects of two 6-quinolinyl chalcones on the integrity of plasma membrane of paracoccidioides brasiliensis.	paracoccidioidomycosis is the most prevalent systemic mycosis in latin america, yet few therapeutic options exist. our aim was to search for new compounds with high efficacy, low toxicity, shorter treatment time and affordable cost. we studied two synthetic 6-quinolinyl chalcones, 3b and 3e, to determine their effects on vero cells, antifungal activity, survival curve, interaction with other drugs and phenotypic effects against several isolates of paracoccidioides spp. in this study, we verified ...	2017	28074055