Publications

brazilian guidelines for the clinical management of paracoccidioidomycosis.	paracoccidioidomycosis is a systemic fungal disease occurring in latin america that is associated with rural environments and agricultural activities. however, the incidence and prevalence of paracoccidiodomycosis is underestimated because of the lack of compulsory notification. if paracoccidiodomycosis is not diagnosed and treated early and adequately, the endemic fungal infection could result in serious sequelae. while the paracoccidioides brasiliensis ( p. brasiliensis ) complex has been know ...	2017	28746570
pulmonary and sinus fungal diseases in non-immunocompromised patients.	the human respiratory tract is exposed daily to airborne fungi, fungal enzymes, and secondary metabolites. the endemic fungi histoplasma capsulatum, coccidioides spp, blastomyces dermatitidis, and paracoccidioides brasiliensis, and occasionally aspergillus fumigatus, are primary pulmonary pathogens of otherwise healthy people. such infections resolve in most people, and only a few infections lead to disease. however, many fungi are directly allergenic by colonising the respiratory tract or indir ...	2017	28774699
the ido-ahr axis controls th17/treg immunity in a pulmonary model of fungal infection.	in infectious diseases, the enzyme indoleamine 2,3 dioxygenase-1 (ido1) that catalyzes the tryptophan (trp) degradation along the kynurenines (kyn) pathway has two main functions, the control of pathogen growth by reducing available trp and immune regulation mediated by the kyn-mediated expansion of regulatory t (treg) cells via aryl hydrocarbon receptor (ahr). in pulmonary paracoccidioidomycosis (pcm) caused by the dimorphic fungus paracoccidioides brasiliensis, ido1 was shown to control the di ...	2017	28791025
subtractive phage display selection for screening and identification of peptide sequences with potential use in serodiagnosis of paracoccidioidomycosis caused by paracoccidioides brasiliensis.	paracoccidioidomycosis (pcm) is a systemic granulomatous disease endemic in latin america whose aetiologic agents are the thermodimorphic fungi paracoccidioides brasiliensis and paracoccidioides lutzii. despite technological advances, some problems have been reported for the fungal antigens used for serological diagnosis, and inconsistencies among laboratories have been reported. the use of synthetic peptides in the serological diagnosis of infectious diseases has proved to be a valuable strateg ...	2017	28796894
approach to fungal infections in human immunodeficiency virus-infected individuals: pneumocystis and beyond.	many fungi cause pulmonary disease in patients with human immunodeficiency virus (hiv) infection. pathogens include pneumocystis jirovecii, cryptococcus neoformans, aspergillus spp, histoplasma capsulatum, coccidioides spp, blastomyces dermatitidis, paracoccidioides brasiliensis, talaromyces marneffei, and emmonsia spp. because symptoms are frequently nonspecific, a high index of suspicion for fungal infection is required for diagnosis. clinical manifestations of fungal infection in hiv-infected ...	2017	28797489
paracoccin distribution supports its role in paracoccidioides brasiliensis growth and dimorphic transformation.	paracoccidioides brasiliensis yeast was reported to express paracoccin, a glcnac-binding protein that displays n-acetyl-β-d-glucosaminidase (nagase) activity. highly specific anti-paracoccin antibodies have been previously used to examine the localization of paracoccin in yeast and inhibit its growth in vitro. in the present study, anti-paracoccin antibodies were used to characterize, by scanning confocal microscopy, the distribution of paracoccin in p. brasiliensis hyphae, transition forms from ...	2017	28846733