Publications

seasonal periodical appearance of hepatozoon canis gamont in the peripheral blood.	we investigated the appearance of gamonts in peripheral leukocytes of 13 hepatozoon canis infected dogs from june 1990 to december 1992. in almost all the dogs, the numbers of gamonts increased from spring to autumn, and decreased from autumn to winter. particularly in the dogs used for hare hunting, a large number of gamonts was detected from spring to autumn. this finding reveals that the gamont increases in number in the dog which ingested the infected ticks during the hunting season.	1993	8286552
vertical transmission of hepatozoon canis in dogs.	we experienced vertical infections of puppies with hepatozoon canis from 1990 to 1992. in 23 of 29 (79.3%) puppies from a total of 6 deliveries, gamonts or meronts were detected from 16 to 60 days after birth. the mother dogs were delivered of the puppies under tick-free conditions treated with an acaricide. there was no chance of infection of the puppies with h. canis after birth. therefore, the vertical transmission of h. canis was supposed to be established in the family of dog.	1993	8286548
detection of neospora caninum in tissue sections using a murine monoclonal antibody.	a murine monoclonal antibody (mab 6g7), isotype igg2a, produced against tachyzoites of neospora caninum (isolate nc-1) reacted specifically with tachyzoites of n. caninum in an indirect immunofluorescent antibody test. mab 6g7 did not react with tachyzoites of toxoplasma gondii, sporozoites of isospora suis, eimeria bovis, or e. tenella, or merozoites of e. bovis in the indirect immunofluorescent antibody test. mab 6g7 reacted positively with both tachyzoites and bradyzoites of n. caninum in an ...	1993	8286458
[hepatozoon canis: an important parasitic infection in dogs].	this paper reports on a case of hepatozoonosis of a dog imported from italy to germany. a survey of the biology and ecology of the causative agent as well as the pathogenesis, clinics, diagnosis, therapy and prophylaxis of hepatozoon canis infection is presented.	1994	8209369
microbesnoitia leoni bwangamoi, 1989, from the african lion (panthera leo) redetermined as a junior synonym of hepatozoon canis (james, 1905) wenyon, 1926.	hepatozoon canis-like schizonts were found in the hearts of 2 lionesses (panthera leo) from kenya. the parasite, initially described as a new genus and new species microbesnoitia leoni bwangamoi, 1989, is determined to be a junior synonym of hapatozoon canis (james, 1905) wenyon, 1926.	1994	8158481
[investigation of nitroblue tetrazolium reduction of neutrophils in the dog infected with hepatozoon canis].	investigation of nitroblue tetrazolium (nbt) reduction of neutrophils was performed in the dog infected with hepatozoon canis. no positive reactions were observed in the parasitized neutrophils by the resting and the stimulated nbt reduction tests. however, results of resting and stimulated nbt reduction tests apparently made no differences between non-parasitized neutrophils of the infected dogs and neutrophils of the non-infected dogs. these findings show that the parasitized neutrophil has no ...	1994	8119329
ultrastructure and cytochemical characteristics of leukocyte infected with hepatozoon canis.	we have observed the ultrastructure of a canine leukocyte infected with hepatozoon canis by transmission electron microscope. the infected leukocytes contained many small vesicles and a few typical granules in the cytoplasm. they also contained a few rough surfaced endoplasmic reticula, mitochondria and a segmented nucleus with condensed chromatin. cytochemical analysis indicated that the infected leukocytes with h. canis contained little alkaline phosphatase, peroxidase, naphthol as-d chloroace ...	1993	8117804
circulating antibodies to hepatozoon canis demonstrated by immunofluorescence.		1994	8011770
hepatozoon canis infection in two dogs.	infection of 60 to 90% of neutrophils with the protozoa, hepatozoon canis, was detected in 2 dogs. clinical signs included lethargy, anorexia, and weight loss. both dogs had severe anemia, leukocytosis, and thrombocytopenia as well as hypoalbuminemia, hyperglobulinemia, and high activities of serum alkaline phosphatase and creatine kinase. both dogs were treated with imidocarb dipropionate and doxycycline. one dog recovered clinically, with disappearance of parasites from wbc. the other dog died ...	1995	7790303
detection of hepatozoon canis oocyst from ticks collected from the infected dogs.	we collected 220 ticks from 58 dogs infected with hepatozoon canis from 1990 to 1992 in yamaguchi and fukuoka prefectures, the western provinces of japan. these ticks were identified as haemaphysalis campanulata, h. longicornis, h. flava, ixodes ovata, and i. nipponensis. by histopathological examination of these ticks, two oocysts which seemed to be those of h. canis were observed in the haemocoele of an adult female h. longicornis and a nymph h. flava tick. the oocyst, about 300 x 150 microns ...	1995	7756400
incidence of brown dog ticks, rhipicephalus sanguineus, at a kennel in okayama prefecture.	twenty two adult dogs suffered from tick infestation at a kennel in okayama prefecture in the summer of 1994. four of them had been introduced from u.s.a. some dogs showed pyoderma, anemia, neutrophilia or eosinophilia. neither babesia gibsoni nor hepatozoon canis was detected on the smear samples of peripheral blood. the ticks detected were morphologically identified as rhipicephalus sanguineus. this case was a rare incidence of the tick in the other areas of japan than okinawa.	1995	7548423
[pathologic anatomy of hepatozoon canis infection].		1982	7178884
experimental transmission of the texas strain of hepatozoon canis.	nine dogs were fed hepatozoon canis-exposed rhipicephalus sanguineus ticks; 6 showed clinical signs suggestive of canine hepatozoonosis, and the parasite was found in sections of muscle tissue from 2 of the dogs. schizont-like cysts were found in the skeletal muscle of both infected dogs as were gametocytes in the circulating leucocytes. periosteal new-bone lesions were seen in 1 dog. attempts to infect a raccoon, 3 cats, 6 laboratory mice, and tick- or canine-cells in vitro, failed.	1984	6542719
the incidence of canine haematozoa in peninsular malaysia.	in 3 urban areas in selangor, peninsular malaysia between 1973 and 1981, blood from 4084 dogs was examined for haematozoa. the following frequencies were found: babesia gibsoni 17.7%; microfilariae of dirofilaria immitis 9.6%; hepatozoon canis 1.2%; b. canis 1.1%; ehrlichia canis 0.2%; trypanosoma evansi 0.1%. a detailed examination of b. gibsoni infections and microfilariasis due to d. immitis with regards to monthly distribution, breed frequency, sex and age, revealed that pedigree and non-ped ...	1985	3922103
hepatozoon sp. in wild carnivores in texas.	twelve coyotes (canis latrans), three bobcats (lynx rufus) and six ocelots (felis pardalis) from the gulf coast of texas were infected with hepatozoon sp. the geographic distribution of infected wild animals coincides with the highest prevalence of hepatozoon canis infection in domestic dogs for which the wild species may act as a reservoir.	1988	3411720
hepatozoonosis in foxes from portugal.	hepatozoon, sp. is described for the first time in foxes (vulpes vulpes silacea) in portugal. of 301 foxes examined, 143 (48%) were infected. the gametocyte was the predominant stage of the life cycle and was found in every organ except the bone marrow, where schizonts were the most abundant stage. the morphological similarity of this parasite's gametocytes to hepatozoon canis is emphasized.	1988	3373641
hepatozoon canis in a dog with oral pyogranulomas and neurologic disease.	a ten-month-old cocker spaniel presented for fever, difficulty walking, and oral lesions. muscle pain, bloody diarrhea, respiratory disease and central nervous system inflammation were found while the animal was hospitalized. merozoites of hepatozoon canis were discovered in association with pyogranulomas in a muscle biopsy. no other etiologic agent for the clinical signs was identified.	1988	3131065
diagnostic parasitology.	diagnosis of parasitic infections in small animals is challenging, interesting, and fun, and involves the recognition of parasite stages based on size, morphology, color, and movement. size and morphology are the major diagnostic parameters, and a calibrated microscope is the essential tool in the diagnostic laboratory. the fecal flotation technique is used routinely for the diagnosis of most parasites that reside within the gastrointestinal tract. the specific gravity and type of solution used ...	1989	2678716
neutrophil myeloperoxidase deficiency associated with canine hepatozoonosis.	hepatozoonosis is a very important disease in dogs in nigeria. hepatozoonosis was reported in nigeria in 18 dogs. the clinical signs included fever, anorexia, loss of weight, lameness, oculonasal discharge and conjunctivitis. hematologic findings included leukocytosis due to neutrophilia and eosinophilia. parasitemia varied from 1 to 9% of the circulating neutrophils in the peripheral blood smears of the dogs examined. hepatozoon canis gametocytes were identified in circulating neutrophils of do ...	1989	2561399
cytochemical identification of canine circulating leucocytes parasitized by the gametocyte of hepatozoon canis.		1991	1836390
first case of hepatozoon canis infection of a dog in japan.		1991	1790224
concurrent hepatozoon canis and toxoplasma gondii infections in a dog.	a female 1-year-old dog died suddenly and was submitted for necropsy. numerous grey-tan-colored nodules were seen in the lungs, brain and lymph nodes. microscopically, the predominant lesion was necrosis associated with numerous toxoplasma gondii tachyzoites. the parasites reacted positively with anti-t. gondii serum in an immunohistochemical test. schizonts of hepatozoon canis were seen in sections of lymph nodes and the spleen.	1992	1496795
hepatozoon canis infection in dogs: clinical, radiographic, and hematologic findings.	hepatozoon canis gametocytes were identified in circulating neutrophils of 3 dogs from different parts of texas. clinical signs included intermittent fever, stiffness, and inappetence. the dogs had marked neutrophilic leukocytosis (35,000--51,000/mm3). parasitemia varied from less than 1% to 60% of the circulating neutrophils. two of the dogs had periosteal new born reaction on the vertebrae, ilia, ribs, and bones of the limbs proximal to the carpus and tarsus. there was no evidence that specifi ...	1978	721677