Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| identification of human acrosomal antigen sp-10 in primates and pigs. | the intra-acrosomal human sperm protein sp-10 was previously designated a "primary vaccine candidate" by a world health organization taskforce on contraceptive vaccines. in the present study, a monoclonal antibody to sp-10 (mhs-10) was employed on western blots to identify immunoreactive sp-10 in sperm extracts from baboon (papio cyanocephalus anubis) and two macaques (macaca mulatta and macaca fascicularis). in each of these primates, the mhs-10 monoclonal antibody recognized a polymorphic patt ... | 1990 | 2337631 |
| effects of anterior corpus callosum section on cortical glucose utilization in baboons. a sequential positron emission tomography study. | cortical glucose utilization was measured under light anaesthesia using positron emission tomography and 18f-fluorodeoxyglucose before and serially after stereotaxic anterior corpus callosum section in 3 adult baboons (papio papio); in 1 animal needles were introduced but callosotomy was not performed ('sham' operation). lesion efficacy was verified by x-ray computerized tomography and by postmortem examination which indicated effective anterior two-thirds callosal section in all 3 baboons, as w ... | 1990 | 2397393 |
| anticonvulsant action of the beta-carboline abecarnil: studies in rodents and baboon, papio papio. | abecarnil (zk 112119; isopropyl-6-benzyloxy-4-methoxymethyl-beta-carboxylate) is a metabolically stable beta-carboline derivative with potent anxiolytic and few sedative and ataxic effects in rodents. the anticonvulsant and muscle relaxant actions of abecarnil have been evaluated in mice, rats, gerbils and baboons. abecarnil raised the threshold for tonic electroconvulsions in mice after corneal but not after auricular application, had no effect on maximal electroshock-induced tonic convulsions ... | 1990 | 1970362 |
| effects of localized, chronic gaba infusions into different cortical areas of the photosensitive baboon, papio papio. | the effects of chronic (7 days) intracortical gaba infusions were investigated in both naturally photosensitive and non-photosensitive baboons. bilateral and unilateral infusions into motor and occipital regions blocked photosensitivity, while premotor and prefrontal cortex infusions had no effect on the electro-clinical manifestations of this type of reflex epilepsy; the monkeys with prefrontal gaba infusions, however, showed selective attention deficits, detected with the delayed response test ... | 1989 | 2464486 |
| lack of effect of aspartame or of l-phenylalanine on photically induced myoclonus in the baboon, papio papio. | the effects of large doses of l-phenylalanine and of aspartame on seizure susceptibility and severity have been assessed in baboons papio papio from senegal which show photosensitive epileptic responses similar to primary generalised epilepsy in man. l-phenylalanine, 50, 150 or 450 mg/kg, or aspartame, 300 or 1000 mg/kg, were administered orally. peak plasma l-phenylalanine concentrations of approximately 2000 mumoles/l occurred 1-4 h after the highest dose of l-phenylalanine or aspartame. the p ... | 1989 | 2502388 |
| gabaergic mechanisms in the pathogenesis and treatment of epilepsy. | 1. evidence relating to the role of gaba in the pathogenesis of epilepsy is reviewed. 2. impaired gabaergic function appears to contribute to seizure susceptibility in a variety of genetically-determined syndromes in animals, e.g. genetically epilepsy prone rats showing sound-induced seizures, gerbils with genetically determined epilepsy, and baboons, papio papio, with photosensitive epilepsy. 3. in epilepsy secondary to a cerebral insult there is some morphological and biochemical evidence for ... | 1989 | 2667605 |
| demonstration of gaba immunoreactive cells in the inferior olive of baboons (papio papio and papio anubis). | the distribution of gamma-aminobutyric acid (gaba)-like immunoreactivity was studied in semithin sections through the inferior olivary complex in two baboon species. about 5% of the olivary neurons were gaba-immunoreactive. the gaba-immunoreactive neurons differed from the large majority of olivary neurons by their smaller size and their lower contents of aspartate, as judged by analysis of alternate sections labelled with an aspartate antiserum. the present observations raise the possibility th ... | 1989 | 2671810 |
| n-methyl-d-aspartate receptors in the cortex and hippocampus of baboon (papio anubis and papio papio). | in vitro autoradiography was used to examine the n-methyl-d-aspartate receptor in the brain of a baboon species, papio anubis, and compared to that of papio papio which exhibits a photosensitive epilepsy. the epilepsy originates in the frontal cortex and is accompanied by an enhanced sensitivity to n-methyl-d-aspartate. in both papio anubis and papio papio, the density of n-methyl-d-aspartate receptors was greatest in the hippocampus, followed by associational areas including frontal cortex, and ... | 1989 | 2573860 |
| phosphorylated thiamine derivatives and cortical activity in the baboon papio papio: effect of intermittent light stimulation. | the effect of intermittent light stimulation (ils) on the distribution of thiamine derivatives in three brain areas (occipital, motor, and premotor) was compared in photosensitive and nonphotosensitive baboons. ils induces paroxysmal discharges in the motor and premotor areas of photosensitive animals only. in baboons submitted to ils, thiamine triphosphate (ttp) decreases in both photosensitive and nonphotosensitive animals; thiamine monophosphate (tmp) increases in photosensitive animals, whic ... | 1989 | 2723664 |
| dopaminergic-cholinergic interaction in a myoclonus of papio papio baboon. | 1989 | 2517809 | |
| supplementary motor area kindling in the photosensitive baboons. | two senegalese baboons (papio papio) were subjected to daily electrical stimulation at the sma. when compared with the results of kindling at different frontal cortical sites, adt and gst at the sma were lower than those at other sites. on the other hand, the number of stimulations required for stage 4 asymmetrical generalization was much greater at the sma (mean of 78.0) than that for the pma (22.5). these findings suggest that partial seizure originating from the pma rather than the sma seems ... | 1989 | 2625802 |
| role of the forebrain commissure and hemispheric independence in photosensitive response of epileptic baboon, papio papio. | the effect of monocular intermittent light stimulation (ils) of either hemivisual field (hvf) of the full visual field (fvf) was examined in papio papio with or without forebrain bisection. ils of the hvf or the fvf in non-bisected baboons produced bisymmetrical and bisynchronous spike and wave which was followed by a self-sustained seizure without eeg evidence of hemispheric independence. ils of the fvf in bisected baboons also produced bilateral spike and wave and self-sustained seizures of a ... | 1988 | 2450734 |
| anatomical atlas of the baboon's brain in the orbito-meatal plane used in experimental positron emission tomography. | an anatomical atlas has been constructed of the brain of the baboon (papio papio) in the orbito-meatal plane (om-plane) which is frequently used in experimental positron emission tomography (pet) investigations. the atlas comprises 12 photographic reproductions of histological brain sections separated by 2.5 mm intervals, and covers telencephalic to pontine brain stem levels. the anatomical atlas was used in analysis of some pet scan images obtained after administration of either a benzodiazepin ... | 1988 | 2835124 |
| seed-eating by west african cercopithecines, with reference to the possible evolution of bilophodont molars. | data on tooth use in eating fruits and seeds were collected on 12 west african monkeys representing five species of cercopithecines, cercopithecus aethiops, cercopithecus campbelli, cercocebus atys, erythrocebus patas, and papio papio. field observations and information in the published literature were used to select fruits for captive feeding trials. a total of over 27,000 tests were conducted to determine the preferences of the monkeys for 78 fruits. data were collected on the selection of fru ... | 1988 | 3364545 |
| gaba-containing neurons in the pontine nuclei of rat, cat and monkey. an immunocytochemical study. | putative gabaergic elements in the pontine nuclei have been studied in the rat, cat and two old world monkeys (macaca mulatta and papio papio) using an antiserum against gaba-glutaraldehyde-protein conjugates and the peroxidase-antiperoxidase method. in addition, an antiserum against glutamate decarboxylase has been used in the cat. for comparison, golgi impregnated material from cat and macaque has been studied. in all species there is a moderately dense plexus of fibres with gaba-like immunore ... | 1988 | 3393281 |
| electroencephalographic manifestations of grand mal epilepsy in africans: observation of relative rarity of interictal abnormalities. | interictal eeg records of nigerian epileptic patients living in lagos and clearly diagnosed as having grand mal epilepsy were compared with those of british epileptic patients with a similar diagnosis. interictal eeg abnormalities (spike and wave discharges, (sw), photoparoxysmal discharges (ppd), and nonspecific changes) were significantly less common in nigerian patients (incidence 15.7%) compared with british patients (incidence 52.9%) irrespective of age or sex of the patients. these finding ... | 1988 | 3134191 |
| case of disseminated african histoplasmosis in a baboon. | an adult red baboon (papio cynocephalus papio) had a severe disseminated case of african histoplasmosis (histoplasma capsulatum var. duboisii) with skin lesions from small pustules to ulcerative granulomas. osteolytic lesions were seen radiographically. treatment with ketoconazole for 6 months was unsuccessful. | 1988 | 3184166 |
| photic epilepsy problems raised in man and animals. | the data gathered in 30 years' study in man and in several animal species, but especially in the papio papio baboon, tend to show that the cortex plays a decisive part in the seizure and interval discharges induced by intermittent light stimulation in photic epilepsy. two regions of the cortex predominate: the frontorolandic and occipital regions. the cortical cortex can, indeed, transmit or control the visual input to the frontorolandic region and can cause intermittent discharges in certain sp ... | 1987 | 3323124 |
| [animal models of epilepsy and experimental seizures]. | animal models of epilepsy are essential for the search of new effective antiepileptic drugs. moreover they may lead to the discovery of the basic neuronal dysfunction(s) which underlies human epilepsies. animal epilepsies as well as experimental seizures are usually considered as valid models of human epilepsies when, and only when, the drugs which are effective in human epilepsies prevent seizures in animals. this, however, precludes finding new drugs for resistant epilepsies. animal models of ... | 1987 | 3116633 |
| the role of visual reafferents during a pointing movement: comparative study between open-loop and closed-loop performances in monkeys before and after unilateral electrolytic lesion of the substantia nigra. | in order to elucidate the compensatory role of visual feedback during movement, two experiments were designed to compare the motor performances of papio papio baboons depending on whether the animals were able to visually control the limb trajectory (visual closed-loop condition) or not (visual open-loop condition). the visuomotor task used consisted of making trained pointing movements towards a stationary target. in experiment a, the baboons were successively presented with these two experimen ... | 1987 | 3556467 |
| glycine-like immunoreactivity in the cerebellum of rat and senegalese baboon, papio papio: a comparison with the distribution of gaba-like immunoreactivity and with [3h]glycine and [3h]gaba uptake. | an antiserum against conjugated glycine was characterized and applied to cerebellar sections of rats and baboons that had been perfusion-fixed with glutaraldehyde. after immunosorbent purification the serum reacted with brain protein-glutaraldehyde-glycine conjugates, but did not stain similar test conjugates prepared from other amino acids, including gaba and beta-alanine. in the rat cerebellum the glycine antiserum selectively labelled a subpopulation of golgi neurons. adjacent vibratome secti ... | 1987 | 3582532 |
| [type b myoclonus in papio papio: results of the central anticholinergic effect of benzodiazepines]. | 1987 | 3427649 | |
| bidirectional effects of beta-carbolines in reflex epilepsy. | derivatives of ethyl-beta-carboline-3-carboxylate, zk 91296, zk 93423 and zk 95962 have potent anticonvulsant activity against sound-induced seizures in audiogenic dba/2 mice and against photically-induced seizures in the baboon, papio papio. the convulsant beta-carbolines, dmcm and beta-ccm, have proconvulsant and convulsant activity in the same animal models. dmcm and beta-ccm are similar in potency as convulsants in dba/2 mice (ed50 value for dmcm: 1.3 mg/kg; ed50 value for beta-ccm; 0.8 mg/k ... | 1987 | 3119161 |
| [study of specific binding sites of benzodiazepines using positron emission tomography in live baboons (papio papio)]. | 1987 | 2831635 | |
| benzodiazepine receptors studied in living primates by positron emission tomography: inverse agonist interactions. | the convulsant actions of methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (dmcm) and of methyl beta-carboline-3-carboxylate (beta-ccm) were evaluated in the baboon (papio papio). dmcm, 0.6-4 mg/kg, induced epileptic seizures with short latency. dmcm convulsive seizures could be blocked by i.v. administration of the benzodiazepine agonist diazepam (10 mg). similarly, beta-ccm, 0.3-3 mg/kg i.v., provoked generalized seizures in the baboons. these seizures were also reversed by the admini ... | 1987 | 3040433 |
| spontaneous hand usage and handedness in a troop of baboons. | hand usage was studied in a troop of 18 guinea baboons (10 adults and 8 young) for spontaneous activities. handedness was determined by an analysis of unimanual activities and bimanual asymmetric activities. the distribution of preferential biases gave 5 right-handers and 2 left-handers, other subjects being ambidextrous. main effects were age related: the strength of the preference was greater for adults than for young; moreover, bimanual activities performed by the adult group were more asymme ... | 1987 | 3608520 |
| [neurotoxicity and cardiotoxicity of bupivacaine on the papio papio baboon]. | 1987 | 3434894 | |
| the protein core of the largest proteoglycan monomer of articular cartilage. gel electrophoretic pattern and tryptophanyl peptide bond cleavage. | the largest proteoglycan monomer of baboon (papio papio) articular cartilage was isolated and the protein rich core was obtained after chondroitinase ac ii and keratanase digestions. on sds-page the core yielded a single band with apparent mr of 290,000. tryptophanyl peptide bond cleavage of the core with n-chlorosuccinimide/urea gave 4 peptides with apparent mr of 105,000, 66,000, 62,000 and 56,000 | 1987 | 3132351 |
| transcallosal response (tcr) in the chronic photosensitive baboon preparation, papio papio. ii. effect of premotor cortical kindling. | the chronological pattern of transcallosal response (tcr) and its recovery cycle were studied by single or paired stimulation of the homotopic primary and the secondary (contralateral) cortical site before, during and after primary site premotor cortical kindling in papio papio. prior to kindling, the sequential pattern of tcr was early positive (p1), negative (n1), late small positive (p2) and large negative (n2) components. the recovery cycle of both p1 and n1 showed a marked supernormal phase ... | 1987 | 2445549 |
| transcallosal response (tcr) in the chronic photosensitive baboon preparation, papio papio. i. premotor cortical stimulation, recovery cycle and neurotropic drug effect. | transcallosal response (tcr) and its recovery cycle were studied in the chronic photosensitive baboon, papio papio. bipolar premotor intracortical stimulation evoked early positive (p1) and negative (n1) sequences followed by late small positivity (p2) and large negativity (n2) in the contralateral homotopic site. the sequential pattern of p1 and n1 was similar to that previously described in acute preparations. the recovery cycle as measured by means of paired stimuli with varying inter-stimulu ... | 1987 | 2445548 |
| learning set formation in a group of guinea baboons (papio papio): importance of the behavioral variable measured. | a recent report of one-trial learning in a group of saddle-back tamarins (saguinus fuscicollis) conflicted with views of learning set formation based on traditional techniques employing isolated subjects. an experiment is reported in which a group of guinea baboons (papio papio) was given a series of discrimination and habit reversal tasks. both one-trial learning and learning set formation occurred. analysis of spatial behavior revealed that the group learned in a single trial to discriminate s ... | 1986 | 31979496 |
| behavioral toxicity of chronic ethosuximide and sodium valproate treatment in the epileptic baboon, papio papio. | the purpose of this study was to assess the effects of chronic administration of gradually increasing doses of the anti-petit mal agents, ethosuximide (15-60 mg/kg/day) and valproic acid (7.5-240 mg/kg/day) on the performance of incremental repeated acquisition and incremental fixed-ratio tasks in the epileptic baboon, papio papio. at approximately equipotent anticonvulsant doses, ethosuximide (45-60 mg/kg/day) was more behaviorally toxic than valproic acid (7.5-60 mg/kg/day), as determined by t ... | 1986 | 3088261 |
| convulsant effect of ro 5-4864, a peripheral type benzodiazepine, on the baboon (papio papio). | the effects of ro 5-4864, a 1,4-benzodiazepine with a high affinity for the peripheral-type benzodiazepine (bz) binding site, were investigated in the baboon (papio papio), which is genetically predisposed to epilepsy. a proconvulsant effect of low doses (1-3 mg/kg, i.v.) of ro 5-4864 was observed by studying its effect on the photic responses induced by intermittent light stimulation in non-photosensitive baboons. higher doses of ro 5-4864 (10 mg/kg, i.v.) were overtly convulsant. the bzs clona ... | 1986 | 3014388 |
| [hypofunction of the central cholinergic neurons is the cause of stimulus-sensitive myoclonus in the baboon papio papio]. | 1986 | 3955725 | |
| cerebrospinal fluid amino acid and monoamine metabolite levels of papio papio: correlation with photosensitivity. | several putative neurotransmitter amino acids and monoamine metabolites were measured in the cerebrospinal fluid of spontaneously photosensitive baboons (papio papio) at different periods with varying degrees of photosensitivity in the same animals. at maximum photosensitivity the inhibitory amino acids gamma-aminobutyric acid and taurine were lower, and those of asparagine (metabolite of the excitatory amino acid aspartate) were higher, than when the animals were not photosensitive. thus a decr ... | 1986 | 2417669 |
| anticonvulsant action of 1,3-dimethyl-5-aminoadamantane. pharmacological studies in rodents and baboon, papio papio. | the anticonvulsant actions of memantine (1,3-dimethyl-5-aminoadamantane) have been evaluated in mice (seizures induced by maximal electroshock, pentylenetetrazol, bicuculline, picrotoxin, 3-mercaptopropionic acid and n-methyl-d,l-aspartic acid) and in photosensitive baboons, papio papio (clonic responses to intermittent photic stimulation). memantine, 5-20 mg/kg, raised the threshold for electroconvulsions and protected mice against the tonic hind limb extension in pentylenetetrazol-, bicucullin ... | 1986 | 3951570 |
| the influence of light stimulation on subcortical potentials evoked by single flashes in photosensitive papio papio. | visual evoked potentials (veps) from the frontorolandic (fr) cortex and from subcortical nuclei (colliculi superioris, pulvinar, corpori geniculati lateralis, centrum medianum, ventralis lateralis) and from pontine reticular formation were analyzed in papio papio monkeys rendered photosensitive by a subconvulsant dose of allylglycine. the veps induced by single flashes were compared statistically with those induced by flashes preceded by trains of intermittent light stimulation (ils). this latte ... | 1986 | 3948815 |
| synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy. | a series of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines derivatives was synthesized and evaluated for anticonvulsant activity. the compounds were screened in mice for their ability to antagonize maximal electroshock- and bicuculline-induced seizures; neurotoxicity was evaluated in the rotorod test. the anticonvulsant activity of the most potent compounds in this series was also examined in kindled amygdaloid rats and in photoepileptic papio papio baboons. phenobarbital, diphenylhydantoin, ca ... | 1986 | 3950916 |
| stimulus-sensitive myoclonus of the baboon papio papio: pharmacological studies reveal interactions between benzodiazepines and the central cholinergic system. | the baboon papio papio develops a nonepileptic myoclonus 20 to 30 min after i.m. benzodiazepine injection. it is characterized by bilateral jerks involving mainly the neck and the trunk, by the absence of any correlative eeg paroxysmal discharge, and by its facilitation during movement or agitation. this myoclonus resembles the intention myoclonus of human patients as seen, for example, after anoxia. we found in experiments on 10 adolescent baboons that atropine alone induced the myoclonus for s ... | 1986 | 3079707 |
| anticonvulsant properties of flunarizine on reflex and generalized models of epilepsy. | the anticonvulsant activity of 1-bis(4-fluorophenyl)methyl-4-(3-phenyl-2-propenyl)-piperazine, flunarizine, was studied after intraperitoneal administration in dba/2 mice (seizures induced by sound), intravenous administration in papio papio (myoclonus induced by photic stimulation) and oral administration in wistar rats (seizures induced by cefazolin). protection against sound-induced seizures was observed after intraperitoneal administration of flunarizine (5-40 mg/kg). the ed50 for suppressio ... | 1986 | 3092126 |
| evaluation of two anticonvulsant amino-pyridazine derivatives in the conflict test in rats. | two amino-phenyl-pyridazine derivatives, sr 41378 and cm 40907, have been reported to antagonize seizures in mice, rats and papio papio baboons with comparable potencies. structurally, sr 41378 differs from cm 40907 by an additional chlorine in position 6 of the phenyl ring. in the present study the activity of these two compounds in the operant approach-avoidance conflict test in rats was examined and compared with that of diazepam, pentobarbital, meprobamate and valproate. sr 41378 increased p ... | 1986 | 3095540 |
| new gene assignments and syntenic groups in the baboon (papio papio). | mdh2, sod2, peps, and itpa were assigned to papio papio chromosomes 3, 4, 5, and 10, respectively, by their concordant segregation with previously assigned gene markers in a set of baboon x mouse somatic cell hybrids. the linkage of np, idh2, sord, mpi, and pkm2 was confirmed, and three other independently segregating markers (mdh1, acy1, and pepb) were identified. syntenic groups described in the baboon are compared to those found in man and in the rhesus monkey. | 1986 | 3459637 |
| [myoclonia. from the myoclonia of papio papio to various human myoclonias]. | the baboon papio papio is naturally predisposed to present several types of myoclonus, the study of which can help in understanding the various human myoclonic symptomatologies. the three types of myoclonus which are studied have been called a, b and c. myoclonus a, which is induced by intermittent photic stimulation in photosensitive animals, is of epileptic nature: it is always preceded by spikes-waves predominating in the fronto-rolandic cortex (areas 4 and 6) and can be followed by secondari ... | 1986 | 3518016 |
| extracellular calcium and potassium concentration changes in chronic epileptic brain tissue. | repetitive electrical stimulation and application of excitatory amino acids lead to decreases in extracellular ca2+ concentration and to rises in extracellular k+ concentration [( ca2+]o, [k+]o) with a typical laminar distribution in a given neo- or allocortical structure. these ionic changes result from transmembrane ion fluxes along their respective electrochemical gradients. epileptogenic drugs that impair repolarizing k+ conductances or inhibitory synaptic transmission enhance such extracell ... | 1986 | 3518350 |
| distribution of central cholinergic neurons in the baboon (papio papio). i. general morphology. | the morphological characteristics of cholinergic neurons in the central nervous system (cns) of the baboon (papio papio) were studied by choline acetyltransferase (chat) immunohistochemistry and acetylcholinesterase (ache) pharmacohistochemistry. the distributions of central cholinergic neurons as visualized by these two histochemical techniques were similar in most, but not all regions of the brain and spinal cord. based upon these observations, central cholinergic neurons that are immunoreacti ... | 1985 | 4056094 |
| distribution of central cholinergic neurons in the baboon (papio papio). ii. a topographic atlas correlated with catecholamine neurons. | the topographic distribution of central cholinergic and catecholaminergic neurons has been investigated in the baboon (papio papio). the perikarya were mapped on an atlas through the brain and spinal cord employing sections processed for acetylcholinesterase (ache) pharmacohistochemistry coupled with choline acetyltransferase (chat) immunohistochemistry or aqueous catecholamine-fluorescence histochemistry. compared with subprimates, there is a remarkable increase in the volume occupied by and th ... | 1985 | 4056095 |
| different neuronal localization of aspartate-like and glutamate-like immunoreactivities in the hippocampus of rat, guinea-pig and senegalese baboon (papio papio), with a note on the distribution of gamma-aminobutyrate. | antisera were raised in rabbits against aspartate or glutamate conjugated to bovine serum albumin by glutaraldehyde. after immunosorbent purification the antisera reacted selectively with brain protein-glutaraldehyde conjugates of the respective amino acids. these results from model systems encouraged us to employ the antisera to study the distribution of free aspartate and glutamate in brain tissue. the aspartate antiserum produced intense staining of interneurons and deep hilar neurons and mod ... | 1985 | 2869443 |
| cm 40907: a structurally novel anticonvulsant in mice, rats and baboons. | cm 40907 [3-(4-hydroxypiperidyl)-6-(2'-chlorophenyl)-pyridazine] is a chemically original compound which possesses the pharmacological properties of a potent, p.o. active anticonvulsant. the anticonvulsant activity of cm 40907 was examined in mice, rats and photosensitive papio-papio baboons and compared to that of phenobarbital, diphenylhydantoin, carbamazepine, sodium valproate and ethosuximide. in mice, cm 40907 antagonized electroconvulsive shock and chemically induced seizures with an overa ... | 1985 | 2989499 |
| 3-amino-beta-carboline derivatives and the benzodiazepine receptor. synthesis of a selective antagonist of the sedative action of diazepam. | seven 3-n-substituted derivatives of 3-amino-beta-carboline were synthesized and their affinities for the benzodiazepine receptor were assessed in vitro. two compounds, 3-(ethylamino)-beta-carboline and 3-[(methoxycarbonyl)amino]-beta-carboline (beta-cmc), showing ic50 values of 460 and 71 nm, respectively, were selected for in vivo studies. the former compound showed long-lasting proconvulsant activity in papio papio baboons while beta-cmc was shown in mice to selectively antagonize the sedativ ... | 1985 | 2989520 |
| 2-amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission--i. anticonvulsant properties. | 2-amino-6-trifluoromethoxy benzothiazole (pk 26124) prevented convulsions induced in rodents by maximal electroshock, inhibitors of the synthesis of gamma-aminobutyric acid (gaba) and ouabain, but was inactive against seizures provoked by gaba antagonists, unlike diazepam, chlordiazepoxide, phenobarbital and valproic acid. 2-amino-6-trifluoromethoxy benzothiazole prevented seizures induced by sound stimuli in dba/2 mice (ed50 = 0.66; 2.1 and 4.1 mg/kg, i.p. according to the seizure component), p ... | 1985 | 3018617 |
| taurine in the hippocampal formation of the senegalese baboon, papio papio: an immunocytochemical study with an antiserum against conjugated taurine. | an antiserum raised against taurine conjugated to bovine serum albumin by glutaraldehyde produced intense staining of hippocampal pyramidal neurons at the ca1/ca3 transition (including ca2) and of a small proportion of the granule cells. strongly immunoreactive neurons were also found in a zone overlapping the second reflected blade in the hilus. most glial cells were unlabeled. | 1985 | 2411586 |
| social facilitation in a troop of guinea baboons (papio papio) living in an enclosure. | a method is described of assessing whether or not social facilitation occurred in a troop of guinea baboons (papio papio) living in an enclosure. the method did not involve the removal of individuals from the troop. the study revealed an interaction between social facilitation and the quality of social relationship involved; affiliative relationships enhanced the social facilitation of leaving an experimental zone. the theoretical implications of this finding are discussed. the method also discl ... | 1985 | 24896698 |
| plasma growth hormone responses to microinfusion of noradrenergic agents into or electrical stimulation of the hypothalamus and amygdala in baboons. | in nine baboons (papio papio) guide cannulae and electrodes were stereotaxically implanted into the medial basal or lateral hypothalamus, the anterior hypothalamus or the dorsal amygdala. plasma gh responses were measured after microinfusion (1 microliter) of the alpha2 adrenergic agonist, clonidine, or the beta adrenergic antagonist, propranolol, or electrical stimulation, in each of these sites. clonidine, 100 nmol/microliter, infused into the medial basal or lateral hypothalamus elevated plas ... | 1985 | 2995219 |
| chemical synaptic transmission is not necessary for epileptic seizures to persist in the baboon papio papio. | the spread and persistence of epileptic seizures have generally been attributed to chemical synaptic interactions. using ion-sensitive microelectrodes, we showed that in the allylglycine-treated photosensitive baboon, prolonged light-induced generalized seizures were accompanied by abnormally large decreases in the concentration of extracellular calcium ions, reaching values at which chemical synaptic transmission was certainly very reduced or blocked. this feature was observed in all cortical l ... | 1985 | 2988992 |
| serum anticonvulsant levels during chronic administration in the immature epileptic baboon, papio papio. | 1985 | 4070243 | |
| physiological sleep myoclonus in baboons. | physiological sleep myoclonus (sleep onset myoclonus and myoclonus during paradoxical sleep) was recorded from the tails of 6 baboons (2 papio hamadryas and 4 papio papio) and its relationship with spontaneously occurring eeg paroxysmal discharges was studied. it was observed that during light slow wave sleep tail myoclonus (sleep onset myoclonus) was almost always associated with eeg paroxysmal discharges predominating in the fronto-rolandic cortex. during deep slow wave sleep the number of eeg ... | 1985 | 2578368 |
| speciation in the baboon and its relation to gamma-chain heterogeneity and to the response to induction of hbf by 5-azacytidine. | in the baboon (papio species), the two nonallelic gamma-genes produce gamma-chains that differ at a minimum at residue 75, where isoleucine (i gamma-chain) or valine (v gamma) may be present. this situation obtains in baboons that are sometimes designated as papio anubis, papio hamadryas, and papio papio. however, in papio cynocephalus, although the i gamma-chains are identical with those in the above mentioned types, the v gamma-chains have the substitutions ala----gly at residue 9 and ala----v ... | 1984 | 6201212 |
| amygdaloid kindling in papio cynocephalus and subsequent recurrent spontaneous seizures. | three baboons, papio cynocephalus, (two photosensitive and one nonphotosensitive) were subjected to amygdaloid kindling. electroclinical profile of seizure development-developed seizure compares very favourably to that described in photosensitive baboons, papio papio, with rapid seizure progression and ultimate emergence of stage 5 bisymmetrical and bisynchronous generalized convulsive state. in addition, one baboon developed spontaneous recurrent seizures which were identical to the kindled sta ... | 1984 | 6532930 |
| guinea baboons (papio papio) at a sleeping site. | descriptive and quantitative observations were made of wild guinea baboons (papio papio) at a regularly used sleeping tree (ceiba pentandra) in senegal. observations concentrated on the transition from darkness before sunrise until the baboons had left the tree. behavior at sleeping sites is affected by a variety of social and nonsocial factors. sleeping postures were adjusted during the night and to suit weather conditions. the baboons began to leave the tree earlier before sunrise in the dry s ... | 1984 | 31986846 |
| action of suriclone in naturally and allyglycine-induced photosensitive baboons, papio papio. | suriclone (sc) is a new anxiolytic compound with a chemical structure different from that of benzodiazepines (bzd) but sc possesses a high affinity for the so-called bzd receptors. sc was tested in the naturally or the allylglycine-treated photosensitive baboon papio papio. as active bzd administered by the intramuscular or oral route, this new compound possesses a marked protective effect against the excessive photosensitivity of the baboons, it blocks myoclonus following eeg spike and waves di ... | 1984 | 6436048 |
| dental microwear and mechanisms in early hominids from laetoli and hadar. | the dentition of early hominids from laetoli and hadar provide evidence of "incisal stripping" and a shear-grinding action for c/p3 complex through microscopic examination of wear facets on dental crowns. this masticatory pattern of dental wear resembles that of papio papio and suggests behavioral analogies between early hominids and papio. | 1984 | 6437237 |
| hpns of baboons during helium-nitrogen-oxygen slow exponential compressions. | from the results obtained with the experimental series corasin (fast compression with he-n2-o2), a method of compression has been developed for the baboon (papio papio) to dive deeper than 600 m. this method utilizes an exponential compression profile with stages of 40 min every 100 m and with the introduction of n2 before each stage from 200 m onward to maintain a concentration of 5.5%. between 0 and 800 m, this procedure did not produce myoclonus or epileptic seizures; tremor appeared beyond 4 ... | 1984 | 6469804 |
| effects of addition of nitrogen during rapid compression of baboons. | a series of dives was carried out to depths of 600 and 800 m seawater (msw) using baboons (papio papio). experiments were designed to study the effects of compression and the use of a he-n2-o2 gas mixture on high-pressure nervous syndrome (hpns). when n2 was added to the he-o2 mixture at the beginning of a linear compression (200 msw/h), the symptoms associated with hpns were still seen; in addition, the electroencephalogram (eeg) changes were more severe than those seen without n2. by use of an ... | 1984 | 6469803 |
| evidence for neurotransmitter abnormalities related to seizure activity in the epileptic baboon. | the experimental evidence that indicates that alterations in neurotransmitter activity exacerbate or diminish seizure responses to intermittent light stimulation in the papio papio model of epilepsy is reviewed. studies of the effects of drugs known to modify the synthesis, storage release, or activity of known or putative neurotransmitters are included. catecholamines, to a lesser extent the indolamine, serotonin, and the inhibitory transmitter gamma-aminobutyric acid all alter seizures as do l ... | 1984 | 6145626 |
| gabaergic agents as anticonvulsants in baboons with photosensitive epilepsy. | gabaergic agents have been evaluated for acute anticonvulsant activity in baboons, papio papio with photosensitive epilepsy. the potent gabaa agonists muscimol and thip are proconvulsant. (-)baclofen, 2 mg/kg suppresses myoclonic responses; higher doses facilitate eeg paroxysmal activity. (s) gamma-vinyl gaba, 100-200 mg/kg, suppresses myoclonic responses for more than 24 h. some derivatives of esters of beta-carboline-3-carboxylate that bind to the benzodiazepine receptor, e.g. zk 91296 and zk ... | 1984 | 6089055 |
| limbic kindling in the forebrain-bisected photosensitive baboon, papio papio. | when forebrain-bisected photosensitive baboons, papio papio, were kindled from the amygdala or hippocampus, bilateralization of convulsive seizure proved difficult, and the final stage of bisymmetrical and bisynchronous convulsive seizure unique to this species did not develop despite more than twice the number of kindling stimulations required for its development in nonbisected baboons. at the secondary site amygdala, convulsive seizure development was suppressed. findings of the present and pr ... | 1984 | 6723588 |
| anticonvulsant actions of ds 103-282. pharmacological studies in rodents and the baboon, papio papio. | the anticonvulsant actions of ds 103-282 [5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3- benzothiadazole , tizanidine], have been evaluated after intraperitoneal administration in dba/2 mice (seizures induced by sound), in swiss s mice (seizures induced by n-methyl-d,l-aspartate; nmdla ) and following intravenous or oral administration in papio papio (seizure responses to intermittent photic stimulation). protection against sound-induced seizures occurred after intraperitoneal administration of ds ... | 1984 | 6377114 |
| the influence of intermittent light stimulation on potentials evoked by single flashes in photosensitive and non-photosensitive papio papio. | the effects of intermittent light stimulation (ils) on visual potentials (veps), evoked in different cortical areas, were statistically studied in baboons either naturally photosensitive or made photosensitive by allylglycine at a subconvulsant dose, as well as in non-photosensitive animals. veps were induced by single flashes (paradigm a) or by flashes preceded by trains of ils (paradigm b). in every baboon, photosensitive or not, the veps induced by paradigm b in the striate area show a decrea ... | 1984 | 6201340 |
| naloxone reversal and morphine exacerbation of neurologic deficits secondary to focal cerebral ischemia in baboons. | the effects of an opiate agonist (morphine) and antagonist (naloxone) on neurologic function in conditions of acute and subacute focal cerebral ischemia were tested in a baboon model. fourteen baboons (papio papio) underwent unilateral transorbital microsurgical occlusion of the middle cerebral artery (mca). blood pressure, heart rate and core temperature were monitored continuously; frequent arterial blood gas measurements were made. cardiac output, cardiac filling pressures, and regional cereb ... | 1984 | 6692145 |
| heterogeneity of hepatic microsomal udp-glucuronosyltransferase(s) activities: comparison between human and mammalian species activities. | the first comparative profiles of udp-glucuronosyltransferase(s) (udpgt) activities obtained under standard conditions in vitro in mammals (man, rat [wistar and gunn], mouse, monkey [papio papio and cynomolgus], pig, guinea pig, rabbit, dog) are presented for 16 aglycones. a decreasing scale of these activities was obtained from planar to bulky molecules. the scale was identical for each of the mammals studied, including man. statistical analysis of the results revealed a division of the aglycon ... | 1984 | 6439424 |
| genetic animal models of epilepsy as a unique resource for the evaluation of anticonvulsant drugs. a review. | genetic animal models of epilepsy comprise genetically predisposed animal species in which seizures either occur spontaneously or in response to sensory stimulation. the major advantage of these naturally occurring epilepsies in animals as models of human epilepsy is that they simulate the clinical situation more closely than any other experimental epilepsy. models with idiopathic spontaneous recurrent seizures are epileptic dogs, tottering mice, and rats with spike-wave absence (petit mal) seiz ... | 1984 | 6439966 |
| behavioural and convulsant actions of two methyl esters of beta-carboline-3-carboxylic acid in photosensitive baboons and in dba/2 mice. | the proconvulsant and convulsant actions of methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (dmcm) and of methyl-beta-carboline-3-carboxylate (beta-ccm) have been evaluated in two animal models of reflex epilepsy, the photosensitive baboon, papio papio, and the audiogenic seizure prone dba/2 mouse. in baboons, myoclonic responses to photic stimulation are markedly enhanced 1 min after dmcm, 0.25 mg/kg i.v. in the absence of photic stimulation dmcm, 0.5 mg/kg i.v. induces a single brief ... | 1984 | 6499918 |
| [connections of the laterodorsal nucleus of the thalamus in the monkey. study of efferents]. | efferent pathways of the ld nucleus of the thalamus were studied in 6 papio-papio baboons with the retrograde transport technique utilizing hrp. injections were made in cingular and parietal cortex and hippocampal formation. large projection from the ld to the cingular and subicular cortex were visualized as reciprocal connections. no pathway to parietal area 7 was found. the course of the fibers is via the fornix, the cingular bundle and the retro-lenticular portion of the internal capsule. the ... | 1984 | 6505490 |
| physostigmine antagonizes benzodiazepine-induced myoclonus in the baboon, papio papio. | the antagonism of some benzodiazepine (bz) actions by physostigmine was investigated in 4 papio papio baboons. as a model of these actions, the myoclonus induced in this species by clonazepam i.m. administration was used. the baboon develops, 20-30 min after bz i.m. injection, a non-epileptic myoclonus characterized by clinical symptomatology (jerks involving mainly the neck and the trunk bilaterally), by the absence of any correlative eeg discharge, and by its facilitation during movement. this ... | 1984 | 6527840 |
| conservation of the human col1a1-tk-gaa synteny and homoeologous assignment in the african green monkey and the baboon (cercopithecoidae). | the pro alpha 1 (i) collagen structural gene (col1a1), the acid alpha-glucosidase (gaa), and the thymidine kinase (tk) genes, known to be closely linked in man (hsa) and mapped to hsa17, were found syntenic in two cercopithecoidae species, the baboon (papio papio, ppa) and the african green monkey (cercopithecus aethiops, cae) and assigned to homoeologous chromosomes, ppa16 and cae19, respectively. the assignment of col1a1 was obtained using two human cdna probes. hind iii restriction sites foun ... | 1984 | 6096258 |
| new gene assignments in the baboon and new chromosome homoeologies with man. | eight new gene assignments were demonstrated in the baboon (papio papio, ppa) by cosegregation analysis of twelve hybrid clones obtained by fusion between ppa fibroblasts and a mouse cell line deficient in thymidine kinase. the following markers and syntenic groups were assigned: sod1 to ppa3, glo-me1 to ppa-4, pgm2 to ppa5, ckbb-sord to ppa7, ldhb to ppa11 and ldha to ppa14. these localizations are in agreement wit hthe following homoeologies with the human karyotype: ppa3-hsa21, ppa4-hsa6, ppa ... | 1983 | 6604489 |
| heredofamilial retinal dystrophy in guinea baboons. i. a histopathologic study. | we performed a histopathologic study of a heredofamilial retinal dystrophy in a colony of guinea baboons. a bull's-eye appearance was noted in the maculas of six baboons of three generations. histologic examination of 13 eyes from this colony showed primary degeneration of both rod and cone cells initially in the parafoveal region, which subsequently involved the photoreceptor cells of the equator and periphery of the retina. the retinal pigment epithelium and choriocapillaris showed mild change ... | 1983 | 6626015 |
| [thymosin-testosterone interaction in spontaneous rosette formation in the baboon monkey (papio papio)]. | thymosine fraction v was shown to exert a stimulation activity on t lymphocytes from papio papio, as determined by e. rosette and active e. rosette formation. testosterone inhibited this effect of thymosin. | 1983 | 6627910 |
| heredofamilial retinal dystrophy in guinea baboons. ii. electron microscopic observations. | electron microscopic study of an inherited retinal degeneration in guinea baboons disclosed primary pathologic alterations in photoreceptor cells. these changes were first seen in the perifoveal region. cell death occurred in two forms: hydropic degeneration and densification and/or necrosis. the hydropic type was mainly associated with cone cells, whereas densification and/or necrosis was largely seen in rod cells. lamellar bodies and granular membrane-bound inclusions were noted in the inner s ... | 1983 | 6639434 |
| antiepileptic action of excitatory amino acid antagonists in the photosensitive baboon, papio papio. | antagonists of excitation induced by dicarboxylic amino acids have been evaluated for acute anticonvulsant activity in baboons, papio papio, with photosensitive epilepsy. 2-amino-7-phosphonoheptanoic acid, 1 mmol/kg, i.v., abolishes myoclonic responses for 5 h. less prolonged protection is seen after cis-2,3-piperidine-dicarboxylic acid, 1-3.3 mmol/kg; 2-amino-5-phosphonovaleric acid, 1-3.3 mmol/kg; or glutamic acid diethyl ester, 1-3.3 mmol/kg. toxic side-effects are prominent after the latter ... | 1983 | 6138738 |
| anticonvulsant action in the photosensitive baboon, papio papio, of a novel beta-carboline derivative, zk 91296. | the anticonvulsant action of ethyl-5-benzyloxy-4-methoxymethyl-beta-carboline-3-carboxylate (zk 91296) has been studied in senegalese baboons, papio papio, with photosensitive epilepsy. myoclonic and paroxysmal electroencephalographic responses to stroboscopic stimulation are diminished or abolished for 2-4 h after zk 91296, 0.25-4 mg/kg, i.v. radioreceptor assay of plasma zk 91296 indicates rapid clearance (t 1/2 alpha, 5-20 min and beta, 60-90 min). in this model of generalised epilepsy zk 912 ... | 1983 | 6311579 |
| differential effects of the benzodiazepine antagonist ro 15-1788 on two types of myoclonus in baboon papio papio. | certain benzodiazepines (bzs) like lorazepam, diazepam or clonazepam induce myoclonus jerks in photosensitive and non-photosensitive baboons. papio papio, which are not accompanied by eeg paroxysmal discharges (type b). the effect of the selective bz antagonist r0 15-1788 was evaluated in this myoclonus. ro 15-1788 completely blocked type b myoclonus without decreasing the level of vigilance in the two types of baboons, and reversed the antiepileptic action of the bzs in the photosensitive ones, ... | 1983 | 6136945 |
| noradrenergic regulation of growth hormone secretion in the baboon. | we have investigated the effects of iv administered noradrenergic agonists and antagonists on plasma gh concentration in the adolescent baboon, papio papio, with the aim of defining the relative roles of adrenergic receptor subtypes (alpha 1, alpha 2, beta 1, and beta 2) in the regulation of gh release. clonidine (0.02 mg/kg) or uk-14,304 (0.02 mg/kg), potent centrally acting alpha 2 noradrenergic agonists, were infused into 24 animals pretreated with either saline, or selective alpha 1 and alph ... | 1983 | 6847820 |
| cerebellar control of eye movements studied with injection of harmaline in the trained baboon. | 1. the alteration of the cortical cerebellar mechanisms resulting from the activation of the olivo-cerebellar pathway by harmaline (h) administered at doses which were subthreshold for skeletomotor tremor (5 mg/kg, im) yields, in the trained baboon (papio papio), a marked decrease of oculomotor system performance. 2. the mean angular excursion of the spontaneous eye movements produced in the dark over a given period of time is increased by 50%. the increase is basically due to an increase of the ... | 1983 | 6847319 |
| comparative assessment of dopamine agonist aporphines as anticonvulsants in two models of reflex epilepsy. | the anticonvulsant action of various aporphine derivatives that act on dopamine receptors has been investigated in two genetically determined animal models--dba/2 mice with sound-induced seizures and baboons papio papio with photically-induced seizures. protection against the clonic and tonic phases of the seizures response in dba/2 mice was seen for 15-60 min after (-)2,10,11-trihydroxy-n-n-propylnoraporphine (1.25 mg/kg) and (-)10,11-methyl-enedioxy-n-n-propylnoraporphine (0.625-1.25 mg/kg) an ... | 1983 | 6415743 |
| limbic status epilepticus: behaviour and sleep alterations after intra-amygdaloid kainic acid microinjections in papio papio baboons. | limbic status epilepticus was produced with single microinjections of kainic acid in the amygdala of baboons (papio papio). long-term studies of the behavioural, electrographic and sleep alterations were performed. during status epilepticus the animals did not display aggressive behaviour. feeding behaviour was diminished. sleep was also deeply disturbed. wakefulness was greatly increased, light slow wave sleep was diminished and deep slow wave sleep and paradoxical sleep was abolished. sleep al ... | 1982 | 6183093 |
| action of progabide in the photosensitive baboon, papio papio. | progabide is a gaba agonist which is nontoxic and crosses the blood-brain barrier. progabide was tested in naturally and allylglycine-induced photosensitive baboons (papio papio). intravenous injection of various doses (30 to 100 mg/kg) of progabide induced a protective effect against intermittent light stimulation (25 hz) in both test situations. this protection lasted 10 to 120 min. this duration was dose-dependent and was generally shorter in allylglycine-treated than in naturally photosensit ... | 1982 | 7140662 |
| the effects of constant light on eeg and seizure activity in the epileptic baboon. | the effects of a change from a standard photoperiod (12:12 ld, 45 fc) to that of constant low level illumination (ll, 5 fc) on electroencephalographic activity (eeg), photic seizures and urine cortisol excretion were investigated in the baboon papio papio. unlike the normal circadian cycle, in which maximal urine cortisol excretion occurred at 08.00 h and minimal at 20.00 h, rhythms in cortisol excretion were free running under constant light, shifting an average of 2 h/week toward an earlier ti ... | 1982 | 6179743 |
| [consequences of pulpectomy followed by canal obturation on the renewal of periodontal ligament in the baboon (papio papio)]. | endodontic root filling following pulpectomy in baboons was shown to induce diphasic consequences at the level of the periodontal ligament according to the time of the observation. initially the specific activity of previously incorporated 3h glycine decreased and the weight of extractible ligament increased at the same time. later on, the turnover slowed down and, unexpectedly, the weight of the extractible ligament decreased. this could be explained since the periodotal ligament was shown to e ... | 1982 | 6812879 |
| the evoked epilepsies. | epileptic activity may be strongly influenced by events occurring outside the central nervous system. at least 6% of recurrent seizures are evoked by specific afferent stimuli, and these are reviewed. the commonest environmental stimulus is light; photosensitive epilepsy occurs not only in humans but also in the baboon (papio papio). recognition and hence avoidance of factors which evoke seizures is an important part of the management of the epilepsies. | 1982 | 7079862 |
| characteristics and origin of frontal paroxysmal responses induced by light stimulation in the papio papio under allylglycine. | in the papio papio, curarized and rendered photosensitive by injection of a subconvulsant dose of dl-allylglycine, single flashes induce frontal paroxysmal evoked responses on condition that they be preceded by trains of intermittent light stimulation (ils). the characteristics of these responses have been compared to those of non-paroxysmal responses induced in the same cortical area by isolated flashes (not preceded by trains of ils). the paroxysmal responses resemble spikes and waves and cons ... | 1982 | 6177492 |
| [myoclonus induced by some benzodiazepines in the papio papio. comparison with myoclonus induced by intermittent light stimulation (author's transl)]. | papio papio may show two different kinds of myoclonus. a first type corresponds to myoclonus induced by photic stimulation (25 hz). this type is always preceded by paroxysmal discharges. another type of myoclonus may be induced, or at least facilitated, by some benzodiazepines, especially lorazepam and, to a lesser extent, diazepam. this type is neither preceded nor accompanied by paroxysmal discharges. a single injection of lorazepam (1 mg/kg i.v.) blocks the first type of myoclonus but favors ... | 1982 | 6125000 |
| cerebellar nuclear topography of simple and synergistic movements in the alert baboon (papio papio). | movements elicited by the stimulation of the cerebellar nuclei were studied in alert baboons chronically prepared. the motor responses were filmed and recorded in eight muscles through chronically implanted electrodes. two types of motor effects were observed: (1) simple movements that concerned the unidirectional displacement of a limb segment. (2) complex movements that involved distinct and frequently noncontiguous muscles were stereotyped and could not be dissociated. these movements are def ... | 1982 | 6889975 |
| anticonvulsant and proconvulsant properties of viloxazine hydrochloride: pharmacological and pharmacokinetic studies in rodents and the epileptic baboon. | viloxazine hcl is evaluated as an anticonvulsant in a wide range of rodent seizure models and in the epileptic baboon (papio papio). in the maximal electroshock test, the oral ed50 for abolition of tonic extension was 9 mg/kg-1 after 30-min pretreatment (mouse) rising to 30 mg/kg-1 after 60 min (mouse and rat). comparable ed50 values were also found for protection against tonic extension in the mouse induced by the administration of the chemical convulsants metrazole or 3-mercaptopropionic acid. ... | 1982 | 6808538 |
| comparative gene mapping of the baboon (papio papio) and man. | seven new gene assignments were demonstrated in the baboon (papio papio) by cosegregation analysis of twelve cell hybrids obtained between ppa fibroblasts and a mouse cell line deficient in thymidine kinase. the following markers and syntenic groups were localized : gusb on ppa3 ; np-mpi-pkm2-idh2 on ppa7; ada on ppa10 and idh1 on ppa12. these results are consistent with the following homoeologies of ppa and hsa chromosomes : ppa3-hsa7 ; ppa7-hsa14 and 15 ; ppa10-hsa20 and ppa12-hsa2q | 1982 | 6979294 |
| production of 18f-labelled 2-deoxy-2-fluoro-d-glucose and preliminary imaging results. | to allow an additional approach to the study of brain metabolism in our laboratory, the synthesis of 18f-2-deoxy-2-fluoro-d-glucose (18fdg) has been adapted by the development of simple, reliable control techniques for routine use. by positron emission computed tomography, it has been established, in the baboon papio papio, that there was a correlation between an epileptic focus and an increase in glucose incorporation. on the other hand, in man, a comparison between the local glucose utilizatio ... | 1982 | 6981509 |
| okt8 human phenotype expressed by papio papio monkey lymphocytes. | the potential cross-reactivity between human and papio papio monkey lymphocyte antigens was investigated using various monoclonal antibodies specific for human t cell subsets and hla-dr antigens. monkey circulating lymphocytes expressed the okt8 antigen, specific for the suppressor/cytotoxic t cell population and the htla antigens. these reactivities were also detected on lymphoid cells in the thymus and lymph nodes of the papio monkey. | 1982 | 6982277 |
| assessment of cell-mediated immunity against coxsackievirus b3-induced myocarditis in a primate model (papio papio). | delayed hypersensitivity and myocarditis were induced in five baboons (papio papio) after inoculation with myocarditic murine coxsackievirus b3 (cvb3m). by means of the [3h]thymidine incorporation assay and the agarose droplet cell migration inhibition assay, specific cell-mediated immunity was detected in all five animals against viral antigens and/or kcl-extractable soluble antigens extracted from the heart of a cvb3m-inoculated baboon. kcl-extracted antigens from normal baboon heart tissues, ... | 1981 | 6260666 |
| naturally occurring yaba tumor in a baboon (papio papio). | 1981 | 6267372 | |
| the influence of d-penicillamine treatment upon seizure activity and trace metal status in the senegalese baboon, papio papio. | reports suggesting participation of trace metals in processes of seizure initiation and propagation in humans and experimental animals prompted an investigation of the relationship between copper and zinc status and seizure activity in the senegalese baboon, papio papio. an evaluation of serum trace metal concentrations in three species of nonhuman primates revealed the presence of elevated zinc levels in p. papio moderately sensitive to photically induced seizures, compared with mildly seizure- ... | 1981 | 7205648 |