Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| in vivo visualization of central muscarinic receptors using [11c]quinuclidinyl benzilate and positron emission tomography in baboons. | the muscarinic antagonist, quinuclidinyl benzilate (qnb), labeled with carbon 11 was used as a radioligand to visualize in vivo by positron emission tomography (pet) the central muscarinic acetylcholine receptors (machr) in baboons (papio papio). the binding characteristics of [11c]qnb showed its specific binding to central machr. [11c]qnb brain uptake was high in cerebral cortex and striatum, areas that are rich in machr, whereas it decreased rapidly in cerebellum, evidencing non-specific bindi ... | 1992 | 1521561 |
| purification of two cytochrome p450 isozymes related to cyp2a and cyp3a gene families from monkey (baboon, papio papio) liver microsomes. cross reactivity with human forms. | two cytochrome p450 isozymes, fa and fi, were isolated and characterized from liver microsomes of phenobarbital-induced baboons (papio papio). the cytochrome fa possesses the same n-terminal amino acid sequence as p450 mk2 from crab-eating monkeys (macaca irus) and closely resembles the human p450 3a isozymes. this cytochrome was able to oxidize nifedipine and hydroxylate testosterone at the 6 beta position. the second baboon cytochrome (fi) is closely related to the p450 2a subfamily and has th ... | 1992 | 1541278 |
| role of the corpus callosum in photosensitive seizures of epileptic baboon papio papio. | 1992 | 1543082 | |
| relationships between benzodiazepine receptors, impairment of gabaergic transmission and convulsant activity of beta-ccm: a pet study in the baboon papio papio. | central type benzodiazepine receptors were studied in vivo by positron emission tomography in brain areas of 2 different groups of the baboon papio papio: non-photosensitive (group 1) and those with an allylglycine-induced decrease in gaba-mediated inhibition (group 2). further, a naturally photosensitive papio papio (+3 level of photosensitive response) was compared to both groups. regional brain binding of the specific benzodiazepine receptor ligand, [11c]ro 15-1788, was not significantly diff ... | 2016 | 1647949 |
| effects of pharmacological manipulation on neurotransmitter and other amino acid levels in the csf of the senegalese baboon papio papio. | the concentrations of gaba, glutamate, aspartate, glycine, taurine, glutamine, asparagine and alanine were determined in the csf of 10 senegalese baboons (papio papio) following initial ketamine anaesthesia and subsequent administration (4 h later) of different compounds known to alter either inhibitory or excitatory neurotransmission. ketamine itself was apparently without effect as the administration of a second dose of ketamine did not significantly alter the levels of any of the amino acids ... | 1991 | 1673360 |
| in vivo benzodiazepine receptor occupancy by cl 218,872 visualized by positron emission tomography in the brain of the living baboon: modulation by gabaergic transmission and relation with anticonvulsant activity. | in vivo benzodiazepine receptor occupancy by increasing doses of cl 218,872 has been evaluated in the baboon papio papio, using (11c) ro 15-1788 as specific radioligand and positron emission tomography as external detection system. although bzr heterogeneity has been previously demonstrated in the brain of the living baboon using pet, we did not observe in our studies that cl 218,872 interacts preferentially with one of the bzr subtypes. the monophasic pattern of the dose dependent cl 218,872 di ... | 1991 | 1673661 |
| myoclonus in papio papio. | 1991 | 1676136 | |
| anticonvulsant activity of two orally active competitive n-methyl-d-aspartate antagonists, cgp 37849 and cgp 39551, against sound-induced seizures in dba/2 mice and photically induced myoclonus in papio papio. | two novel n-methyl-d-aspartate (nmda) antagonists, dl-(e)-2-amino-4-methyl-5-phosphono-3-pentenoic acid cpg 37849 and the corresponding 1-ethyl ester cgp 39551, were tested as anticonvulsants in dba/2 mice and photosensitive senegalese baboons, papio papio. in dba/2 mice, cgp 37849 is more potent than cgp 39551 when administered intracerebroventricularly (i.c.v.) or intraperitoneally (i.p.) (ed50 for suppression of clonic seizures at 60 min: i.c.v. 0.038 and 0.21 nmol; i.p. 3.40 and 19.1 mumol/k ... | 2006 | 1678345 |
| the non-n-methyl-d-aspartate receptor antagonists, gyki 52466 and nbqx are anticonvulsant in two animal models of reflex epilepsy. | the effect of i.p. or i.v. administration of the non-n-methyl-d-aspartate antagonists, gyki 52466 (1-(4-aminophenyl)-4-methyl-7,8-methylendioxy-5h-2,3-benzodiazepin e.hcl, molecular weight 330) and nbqx (2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)-quinoxaline, molecular weight 342) on sound-induced seizures in rats and photically induced myoclonus in baboons was studied. in both species an anticonvulsant effect occurred 15-60 min after administration of gyki 52466 or nbqx. the ed50 value for clon ... | 1991 | 1686756 |
| effects of drugs influencing the noradrenergic neurotransmission on nonepileptic myoclonus of papio papio baboon. | 1991 | 1687862 | |
| drugs influencing the gabaergic neurotransmission have no effect on the non-epileptic myoclonus of baboons. | in papio papio baboons benzodiazepines can facilitate the appearance of a naturally occurring non-epileptic myoclonus, suggesting a possible role of gabaergic transmission in their physiopathology. nevertheless, as this myoclonus is blocked by physostigmine, the effect of benzodiazepines is probably due to their indirect action on the cholinergic system. therefore, in this study, we report the effects on the non-epileptic myoclonus of drugs influencing gabaergic transmission. systemic injections ... | 1991 | 1713829 |
| epileptic manifestations and influence on sleep in the baboon papio papio. | 1991 | 1760101 | |
| tacrine derivative in the myoclonus b of papio papio baboons. | 1991 | 1818688 | |
| calcium-binding protein (calbindin-d28k) and parvalbumin immunocytochemistry in the normal and epileptic human hippocampus. | the calcium-binding proteins calbindin-d28k (cabp) and parvalbumin (pv) were localized in the "normal" and "epileptic" human hippocampus to address the possible relationship between the expression of these constitutive cytosolic calcium-binding proteins and the resistance or selective vulnerability of different hippocampal neuron populations in temporal lobe epilepsy. compared to rodents and a baboon (papio papio), the pattern of cabp-like immunoreactivity (li) in the "normal" human hippocampus ... | 1991 | 1865007 |
| effect of dn-1417 on photosensitivity and cortically kindled seizure in senegalese baboons, papio papio. | the effect of dn-1417, a thyrotropin-releasing hormone (trh) analogue, on photosensitivity and cortically kindled seizures was examined in seven senegalese baboons (papio papio). intravenous (i.v.) administration of 2 mg/kg had no effect on either photosensitivity or cortically kindled seizures. when this agent was administered intracisternally, both the photomyoclonic response and cortically kindled seizures were suppressed for 4-5 days. a study of the transcallosal response also showed a long- ... | 2016 | 1898719 |
| language-apparent reflex epilepsy. | an adolescent with photosensitive epilepsy had absence seizures reproduced by forced voluntary eye closure in light or in darkness, independent of eyelid immobilization or ocular elevation. attacks preferably occurred while speaking spanish, her second language, mediated through brief, strong, automatic closing of the eyes during difficult word retrieval. complex other multidirectional ocular movements or blinking, cognitive and language tasks were ineffective. frontorolandic cortical epileptoge ... | 1991 | 1908752 |
| anticonvulsant action of the beta-carboline abecarnil: studies in rodents and baboon, papio papio. | abecarnil (zk 112119; isopropyl-6-benzyloxy-4-methoxymethyl-beta-carboxylate) is a metabolically stable beta-carboline derivative with potent anxiolytic and few sedative and ataxic effects in rodents. the anticonvulsant and muscle relaxant actions of abecarnil have been evaluated in mice, rats, gerbils and baboons. abecarnil raised the threshold for tonic electroconvulsions in mice after corneal but not after auricular application, had no effect on maximal electroshock-induced tonic convulsions ... | 1990 | 1970362 |
| infectivity of trypanosoma (trypanozoon) brucei gambiense for baboons (papio hamadryas, papio papio). | in order to study sensitivity or resistance of t.b. gambiense to baboon serum, two species of baboons, p. hamadryas and p. papio were inoculated with t.b. gambiense clone litat 1.1. both species were receptive to infection but, parasitological and immunological parameters showed that p. papio was more trypanotolerant than p. hamadryas. the vat-specific trypanolysis test and the elisa, using moab for circulating antigen detection may be appropriate for the diagnosis of human trypanosomiasis due t ... | 1991 | 2042999 |
| reflex reticular myoclonus: relationship to some brainstem pathophysiological mechanisms. | two patients with reflex reticular myoclonus [rrm] were tested electrophysiologically and pharmacologically. in one of the cases the underlying disease was chronic lyme borreliosis. in the other, the rrm attacks may have been associated with procarbazine therapy applied for hodgkin's disease. no cortical lesion could be demonstrated either clinically or electrophysiologically [eeg, averaged eeg preceeding the jerks, ssep]. an emg analysis of the jerks revealed the shortest latency in the muscles ... | 1991 | 2048395 |
| gaba withdrawal syndrome: a model of the epilepsia partialis continua. | after the chronic infusion of gaba into the cortex of baboon papio papio, a sudden stop of the infusion provoked cortical epileptic discharges around the infused area. and the baboon exhibited partial epilepsy for about 3 days. the result suggested that gaba withdrawal syndrome should be a good model not only to understand the mechanism of epilepsia partialis continua but also partial epilepsy with a circumscribed cortical focus. | 1990 | 2124304 |
| unexpected potentializing effect of a tacrine derivative (9-amino-7-methoxy-1,2,3,4 tetrahydroacridine) upon the non-epileptic myoclonus in baboons papio papio. | 1. the influence of 7-methoxytacrine (7-meota) on the non epileptic myoclonus of the papio papio baboon was studied in 5 animals. 2. this type of myoclonus is thought to depend on a cholinergic system dysfunction since it can be induced by atropine and blocked by physostigmine. 3. 7-meota, a tacrine derivative, is believed to display a conspicuous anticholinesterase activity but, surprisingly, it here potentiated the non epileptic myoclonus occuring either spontaneously or induced by atropine. 4 ... | 1990 | 2126145 |
| distribution of distinct arachidonoyl-specific and non-specific isoenzymes of diacylglycerol kinase in baboon (papio cynocephalus) tissues. | we investigated the diacyglycerol kinase species present in several baboon tissues using the substrates sn-1-stearoyl-2-arachidonoyl diacylglycerol and sn-1,2-didecanoyl diacylglycerol. chromatography of octyl glucoside extracts of the baboon (papio cynocephalus papio) tissues on hydroxyapatite columns revealed the presence of three diacylglycerol kinase species with different substrate preferences. one species markedly 'preferred' the substrate sn-1-stearoyl-2-arachidonoylglycerol, the two othe ... | 1990 | 2155609 |
| quantitative evaluation of benzodiazepine receptors in live papio papio baboons using positron emission tomography. | the binding of the 11c-labeled benzodiazepine antagonist ro 15-1788 (flumazenil) was measured in the neocortex of live papio papio baboons by positron emission tomography. this allowed us to calculate in vivo (i.e., at physiological temperature, neurotransmitters concentrations, and ionic environment) the apparent density of available benzodiazepine receptors (b'max) and the dissociation constant of ro 15-1788 (kd). by coadministering increasing doses of unlabeled ro 15-1788 with [11c]ro 15-1788 ... | 1990 | 2172764 |
| [value of the monkey papio papio for the study of epilepsy]. | the baboon papio papio is the only animal model showing a natural photosensitive epilepsy very similar to that observed in some human epileptic patients. in the baboon, intermittent light stimulation (ils) induces bilateral and synchronous myoclonic twitches which are associated with paroxysmal discharges (pds) predominating in the frontal cortex, and can be followed by generalized tonic-clonic seizures. we were able to demonstrate the motor cortical origin of all these manifestations since neur ... | 1990 | 2186340 |
| [epithelial and stromal healing after radial keratotomy. scanning electron microscopy analysis]. | a study of corneal healing after radial keratotomy was conducted under scanning electron microscopy in 28 papio-papio baboons. the appearance of the incisions after follow-ups ranging from one hour to three and a half years postoperatively permits to emit some hypotheses regarding the precise mechanisms of action of radial keratotomy, as well as those governing any functional or anatomical complications susceptible to occur after the operation. | 2006 | 2235013 |
| anticonvulsant activity of the nmda antagonists, d(-)4-(3-phosphonopropyl) piperazine-2-carboxylic acid (d-cpp) and d(-)(e)-4-(3-phosphonoprop-2-enyl) piperazine-2-carboxylic acid (d-cppene) in a rodent and a primate model of reflex epilepsy. | d-(-)4-(3-phosphonopropyl)piperazine-2-carboxylic acid (d-cpp) and its unsaturated analogue (d(-)(e)-4-(3-phosphonoprop-2-enyl) piperazine-2-carboxylic acid (d-cppene) have been administered to dba/2 mice (intracerebroventricularly, i.c.v., intraperitoneally, i.p., and orally, p.o.) and to photosensitive baboons, papio papio (intravenously, i.v., and orally), and their effects on reflexly induced epileptic responses assessed. in dba/2 mice the clonic phase of the seizure response to sound is sup ... | 1990 | 2292244 |
| identification of human acrosomal antigen sp-10 in primates and pigs. | the intra-acrosomal human sperm protein sp-10 was previously designated a "primary vaccine candidate" by a world health organization taskforce on contraceptive vaccines. in the present study, a monoclonal antibody to sp-10 (mhs-10) was employed on western blots to identify immunoreactive sp-10 in sperm extracts from baboon (papio cyanocephalus anubis) and two macaques (macaca mulatta and macaca fascicularis). in each of these primates, the mhs-10 monoclonal antibody recognized a polymorphic patt ... | 1990 | 2337631 |
| effects of anterior corpus callosum section on cortical glucose utilization in baboons. a sequential positron emission tomography study. | cortical glucose utilization was measured under light anaesthesia using positron emission tomography and 18f-fluorodeoxyglucose before and serially after stereotaxic anterior corpus callosum section in 3 adult baboons (papio papio); in 1 animal needles were introduced but callosotomy was not performed ('sham' operation). lesion efficacy was verified by x-ray computerized tomography and by postmortem examination which indicated effective anterior two-thirds callosal section in all 3 baboons, as w ... | 1990 | 2397393 |
| taurine in the hippocampal formation of the senegalese baboon, papio papio: an immunocytochemical study with an antiserum against conjugated taurine. | an antiserum raised against taurine conjugated to bovine serum albumin by glutaraldehyde produced intense staining of hippocampal pyramidal neurons at the ca1/ca3 transition (including ca2) and of a small proportion of the granule cells. strongly immunoreactive neurons were also found in a zone overlapping the second reflected blade in the hilus. most glial cells were unlabeled. | 1985 | 2411586 |
| cerebrospinal fluid amino acid and monoamine metabolite levels of papio papio: correlation with photosensitivity. | several putative neurotransmitter amino acids and monoamine metabolites were measured in the cerebrospinal fluid of spontaneously photosensitive baboons (papio papio) at different periods with varying degrees of photosensitivity in the same animals. at maximum photosensitivity the inhibitory amino acids gamma-aminobutyric acid and taurine were lower, and those of asparagine (metabolite of the excitatory amino acid aspartate) were higher, than when the animals were not photosensitive. thus a decr ... | 1986 | 2417669 |
| transcallosal response (tcr) in the chronic photosensitive baboon preparation, papio papio. i. premotor cortical stimulation, recovery cycle and neurotropic drug effect. | transcallosal response (tcr) and its recovery cycle were studied in the chronic photosensitive baboon, papio papio. bipolar premotor intracortical stimulation evoked early positive (p1) and negative (n1) sequences followed by late small positivity (p2) and large negativity (n2) in the contralateral homotopic site. the sequential pattern of p1 and n1 was similar to that previously described in acute preparations. the recovery cycle as measured by means of paired stimuli with varying inter-stimulu ... | 1987 | 2445548 |
| transcallosal response (tcr) in the chronic photosensitive baboon preparation, papio papio. ii. effect of premotor cortical kindling. | the chronological pattern of transcallosal response (tcr) and its recovery cycle were studied by single or paired stimulation of the homotopic primary and the secondary (contralateral) cortical site before, during and after primary site premotor cortical kindling in papio papio. prior to kindling, the sequential pattern of tcr was early positive (p1), negative (n1), late small positive (p2) and large negative (n2) components. the recovery cycle of both p1 and n1 showed a marked supernormal phase ... | 1987 | 2445549 |
| role of the forebrain commissure and hemispheric independence in photosensitive response of epileptic baboon, papio papio. | the effect of monocular intermittent light stimulation (ils) of either hemivisual field (hvf) of the full visual field (fvf) was examined in papio papio with or without forebrain bisection. ils of the hvf or the fvf in non-bisected baboons produced bisymmetrical and bisynchronous spike and wave which was followed by a self-sustained seizure without eeg evidence of hemispheric independence. ils of the fvf in bisected baboons also produced bilateral spike and wave and self-sustained seizures of a ... | 1988 | 2450734 |
| effects of localized, chronic gaba infusions into different cortical areas of the photosensitive baboon, papio papio. | the effects of chronic (7 days) intracortical gaba infusions were investigated in both naturally photosensitive and non-photosensitive baboons. bilateral and unilateral infusions into motor and occipital regions blocked photosensitivity, while premotor and prefrontal cortex infusions had no effect on the electro-clinical manifestations of this type of reflex epilepsy; the monkeys with prefrontal gaba infusions, however, showed selective attention deficits, detected with the delayed response test ... | 1989 | 2464486 |
| lack of effect of aspartame or of l-phenylalanine on photically induced myoclonus in the baboon, papio papio. | the effects of large doses of l-phenylalanine and of aspartame on seizure susceptibility and severity have been assessed in baboons papio papio from senegal which show photosensitive epileptic responses similar to primary generalised epilepsy in man. l-phenylalanine, 50, 150 or 450 mg/kg, or aspartame, 300 or 1000 mg/kg, were administered orally. peak plasma l-phenylalanine concentrations of approximately 2000 mumoles/l occurred 1-4 h after the highest dose of l-phenylalanine or aspartame. the p ... | 1989 | 2502388 |
| effect of macular and peripheral retina coagulation on photosensitive epilepsy in the forebrain bisected baboon, papio papio. | the effects of macular and peripheral retina coagulation were examined in photosensitive baboons, papio papio (pp), with or without forebrain bisection. the temporal part of the macula and surrounding retina of the left eye were coagulated with an argon laser and later confirmed histologically. in forebrain nonbisected baboons, intermittent light stimulation of the operated eye produced bisymmetrical and bisynchronous spikes and waves and self-sustained seizures. in forebrain-bisected baboons in ... | 2006 | 2507308 |
| dopaminergic-cholinergic interaction in a myoclonus of papio papio baboon. | 1989 | 2517809 | |
| n-methyl-d-aspartate receptors in the cortex and hippocampus of baboon (papio anubis and papio papio). | in vitro autoradiography was used to examine the n-methyl-d-aspartate receptor in the brain of a baboon species, papio anubis, and compared to that of papio papio which exhibits a photosensitive epilepsy. the epilepsy originates in the frontal cortex and is accompanied by an enhanced sensitivity to n-methyl-d-aspartate. in both papio anubis and papio papio, the density of n-methyl-d-aspartate receptors was greatest in the hippocampus, followed by associational areas including frontal cortex, and ... | 1989 | 2573860 |
| physiological sleep myoclonus in baboons. | physiological sleep myoclonus (sleep onset myoclonus and myoclonus during paradoxical sleep) was recorded from the tails of 6 baboons (2 papio hamadryas and 4 papio papio) and its relationship with spontaneously occurring eeg paroxysmal discharges was studied. it was observed that during light slow wave sleep tail myoclonus (sleep onset myoclonus) was almost always associated with eeg paroxysmal discharges predominating in the fronto-rolandic cortex. during deep slow wave sleep the number of eeg ... | 1985 | 2578368 |
| supplementary motor area kindling in the photosensitive baboons. | two senegalese baboons (papio papio) were subjected to daily electrical stimulation at the sma. when compared with the results of kindling at different frontal cortical sites, adt and gst at the sma were lower than those at other sites. on the other hand, the number of stimulations required for stage 4 asymmetrical generalization was much greater at the sma (mean of 78.0) than that for the pma (22.5). these findings suggest that partial seizure originating from the pma rather than the sma seems ... | 1989 | 2625802 |
| gabaergic mechanisms in the pathogenesis and treatment of epilepsy. | 1. evidence relating to the role of gaba in the pathogenesis of epilepsy is reviewed. 2. impaired gabaergic function appears to contribute to seizure susceptibility in a variety of genetically-determined syndromes in animals, e.g. genetically epilepsy prone rats showing sound-induced seizures, gerbils with genetically determined epilepsy, and baboons, papio papio, with photosensitive epilepsy. 3. in epilepsy secondary to a cerebral insult there is some morphological and biochemical evidence for ... | 1989 | 2667605 |
| demonstration of gaba immunoreactive cells in the inferior olive of baboons (papio papio and papio anubis). | the distribution of gamma-aminobutyric acid (gaba)-like immunoreactivity was studied in semithin sections through the inferior olivary complex in two baboon species. about 5% of the olivary neurons were gaba-immunoreactive. the gaba-immunoreactive neurons differed from the large majority of olivary neurons by their smaller size and their lower contents of aspartate, as judged by analysis of alternate sections labelled with an aspartate antiserum. the present observations raise the possibility th ... | 1989 | 2671810 |
| phosphorylated thiamine derivatives and cortical activity in the baboon papio papio: effect of intermittent light stimulation. | the effect of intermittent light stimulation (ils) on the distribution of thiamine derivatives in three brain areas (occipital, motor, and premotor) was compared in photosensitive and nonphotosensitive baboons. ils induces paroxysmal discharges in the motor and premotor areas of photosensitive animals only. in baboons submitted to ils, thiamine triphosphate (ttp) decreases in both photosensitive and nonphotosensitive animals; thiamine monophosphate (tmp) increases in photosensitive animals, whic ... | 1989 | 2723664 |
| [study of specific binding sites of benzodiazepines using positron emission tomography in live baboons (papio papio)]. | 1987 | 2831635 | |
| anatomical atlas of the baboon's brain in the orbito-meatal plane used in experimental positron emission tomography. | an anatomical atlas has been constructed of the brain of the baboon (papio papio) in the orbito-meatal plane (om-plane) which is frequently used in experimental positron emission tomography (pet) investigations. the atlas comprises 12 photographic reproductions of histological brain sections separated by 2.5 mm intervals, and covers telencephalic to pontine brain stem levels. the anatomical atlas was used in analysis of some pet scan images obtained after administration of either a benzodiazepin ... | 1988 | 2835124 |
| different neuronal localization of aspartate-like and glutamate-like immunoreactivities in the hippocampus of rat, guinea-pig and senegalese baboon (papio papio), with a note on the distribution of gamma-aminobutyrate. | antisera were raised in rabbits against aspartate or glutamate conjugated to bovine serum albumin by glutaraldehyde. after immunosorbent purification the antisera reacted selectively with brain protein-glutaraldehyde conjugates of the respective amino acids. these results from model systems encouraged us to employ the antisera to study the distribution of free aspartate and glutamate in brain tissue. the aspartate antiserum produced intense staining of interneurons and deep hilar neurons and mod ... | 1985 | 2869443 |
| chemical synaptic transmission is not necessary for epileptic seizures to persist in the baboon papio papio. | the spread and persistence of epileptic seizures have generally been attributed to chemical synaptic interactions. using ion-sensitive microelectrodes, we showed that in the allylglycine-treated photosensitive baboon, prolonged light-induced generalized seizures were accompanied by abnormally large decreases in the concentration of extracellular calcium ions, reaching values at which chemical synaptic transmission was certainly very reduced or blocked. this feature was observed in all cortical l ... | 1985 | 2988992 |
| cm 40907: a structurally novel anticonvulsant in mice, rats and baboons. | cm 40907 [3-(4-hydroxypiperidyl)-6-(2'-chlorophenyl)-pyridazine] is a chemically original compound which possesses the pharmacological properties of a potent, p.o. active anticonvulsant. the anticonvulsant activity of cm 40907 was examined in mice, rats and photosensitive papio-papio baboons and compared to that of phenobarbital, diphenylhydantoin, carbamazepine, sodium valproate and ethosuximide. in mice, cm 40907 antagonized electroconvulsive shock and chemically induced seizures with an overa ... | 1985 | 2989499 |
| 3-amino-beta-carboline derivatives and the benzodiazepine receptor. synthesis of a selective antagonist of the sedative action of diazepam. | seven 3-n-substituted derivatives of 3-amino-beta-carboline were synthesized and their affinities for the benzodiazepine receptor were assessed in vitro. two compounds, 3-(ethylamino)-beta-carboline and 3-[(methoxycarbonyl)amino]-beta-carboline (beta-cmc), showing ic50 values of 460 and 71 nm, respectively, were selected for in vivo studies. the former compound showed long-lasting proconvulsant activity in papio papio baboons while beta-cmc was shown in mice to selectively antagonize the sedativ ... | 1985 | 2989520 |
| plasma growth hormone responses to microinfusion of noradrenergic agents into or electrical stimulation of the hypothalamus and amygdala in baboons. | in nine baboons (papio papio) guide cannulae and electrodes were stereotaxically implanted into the medial basal or lateral hypothalamus, the anterior hypothalamus or the dorsal amygdala. plasma gh responses were measured after microinfusion (1 microliter) of the alpha2 adrenergic agonist, clonidine, or the beta adrenergic antagonist, propranolol, or electrical stimulation, in each of these sites. clonidine, 100 nmol/microliter, infused into the medial basal or lateral hypothalamus elevated plas ... | 1985 | 2995219 |
| convulsant effect of ro 5-4864, a peripheral type benzodiazepine, on the baboon (papio papio). | the effects of ro 5-4864, a 1,4-benzodiazepine with a high affinity for the peripheral-type benzodiazepine (bz) binding site, were investigated in the baboon (papio papio), which is genetically predisposed to epilepsy. a proconvulsant effect of low doses (1-3 mg/kg, i.v.) of ro 5-4864 was observed by studying its effect on the photic responses induced by intermittent light stimulation in non-photosensitive baboons. higher doses of ro 5-4864 (10 mg/kg, i.v.) were overtly convulsant. the bzs clona ... | 1986 | 3014388 |
| 2-amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission--i. anticonvulsant properties. | 2-amino-6-trifluoromethoxy benzothiazole (pk 26124) prevented convulsions induced in rodents by maximal electroshock, inhibitors of the synthesis of gamma-aminobutyric acid (gaba) and ouabain, but was inactive against seizures provoked by gaba antagonists, unlike diazepam, chlordiazepoxide, phenobarbital and valproic acid. 2-amino-6-trifluoromethoxy benzothiazole prevented seizures induced by sound stimuli in dba/2 mice (ed50 = 0.66; 2.1 and 4.1 mg/kg, i.p. according to the seizure component), p ... | 1985 | 3018617 |
| benzodiazepine receptors studied in living primates by positron emission tomography: inverse agonist interactions. | the convulsant actions of methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (dmcm) and of methyl beta-carboline-3-carboxylate (beta-ccm) were evaluated in the baboon (papio papio). dmcm, 0.6-4 mg/kg, induced epileptic seizures with short latency. dmcm convulsive seizures could be blocked by i.v. administration of the benzodiazepine agonist diazepam (10 mg). similarly, beta-ccm, 0.3-3 mg/kg i.v., provoked generalized seizures in the baboons. these seizures were also reversed by the admini ... | 1987 | 3040433 |
| stimulus-sensitive myoclonus of the baboon papio papio: pharmacological studies reveal interactions between benzodiazepines and the central cholinergic system. | the baboon papio papio develops a nonepileptic myoclonus 20 to 30 min after i.m. benzodiazepine injection. it is characterized by bilateral jerks involving mainly the neck and the trunk, by the absence of any correlative eeg paroxysmal discharge, and by its facilitation during movement or agitation. this myoclonus resembles the intention myoclonus of human patients as seen, for example, after anoxia. we found in experiments on 10 adolescent baboons that atropine alone induced the myoclonus for s ... | 1986 | 3079707 |
| behavioral toxicity of chronic ethosuximide and sodium valproate treatment in the epileptic baboon, papio papio. | the purpose of this study was to assess the effects of chronic administration of gradually increasing doses of the anti-petit mal agents, ethosuximide (15-60 mg/kg/day) and valproic acid (7.5-240 mg/kg/day) on the performance of incremental repeated acquisition and incremental fixed-ratio tasks in the epileptic baboon, papio papio. at approximately equipotent anticonvulsant doses, ethosuximide (45-60 mg/kg/day) was more behaviorally toxic than valproic acid (7.5-60 mg/kg/day), as determined by t ... | 1986 | 3088261 |
| anticonvulsant properties of flunarizine on reflex and generalized models of epilepsy. | the anticonvulsant activity of 1-bis(4-fluorophenyl)methyl-4-(3-phenyl-2-propenyl)-piperazine, flunarizine, was studied after intraperitoneal administration in dba/2 mice (seizures induced by sound), intravenous administration in papio papio (myoclonus induced by photic stimulation) and oral administration in wistar rats (seizures induced by cefazolin). protection against sound-induced seizures was observed after intraperitoneal administration of flunarizine (5-40 mg/kg). the ed50 for suppressio ... | 1986 | 3092126 |
| evaluation of two anticonvulsant amino-pyridazine derivatives in the conflict test in rats. | two amino-phenyl-pyridazine derivatives, sr 41378 and cm 40907, have been reported to antagonize seizures in mice, rats and papio papio baboons with comparable potencies. structurally, sr 41378 differs from cm 40907 by an additional chlorine in position 6 of the phenyl ring. in the present study the activity of these two compounds in the operant approach-avoidance conflict test in rats was examined and compared with that of diazepam, pentobarbital, meprobamate and valproate. sr 41378 increased p ... | 1986 | 3095540 |
| [animal models of epilepsy and experimental seizures]. | animal models of epilepsy are essential for the search of new effective antiepileptic drugs. moreover they may lead to the discovery of the basic neuronal dysfunction(s) which underlies human epilepsies. animal epilepsies as well as experimental seizures are usually considered as valid models of human epilepsies when, and only when, the drugs which are effective in human epilepsies prevent seizures in animals. this, however, precludes finding new drugs for resistant epilepsies. animal models of ... | 1987 | 3116633 |
| bidirectional effects of beta-carbolines in reflex epilepsy. | derivatives of ethyl-beta-carboline-3-carboxylate, zk 91296, zk 93423 and zk 95962 have potent anticonvulsant activity against sound-induced seizures in audiogenic dba/2 mice and against photically-induced seizures in the baboon, papio papio. the convulsant beta-carbolines, dmcm and beta-ccm, have proconvulsant and convulsant activity in the same animal models. dmcm and beta-ccm are similar in potency as convulsants in dba/2 mice (ed50 value for dmcm: 1.3 mg/kg; ed50 value for beta-ccm; 0.8 mg/k ... | 1987 | 3119161 |
| the protein core of the largest proteoglycan monomer of articular cartilage. gel electrophoretic pattern and tryptophanyl peptide bond cleavage. | the largest proteoglycan monomer of baboon (papio papio) articular cartilage was isolated and the protein rich core was obtained after chondroitinase ac ii and keratanase digestions. on sds-page the core yielded a single band with apparent mr of 290,000. tryptophanyl peptide bond cleavage of the core with n-chlorosuccinimide/urea gave 4 peptides with apparent mr of 105,000, 66,000, 62,000 and 56,000 | 1987 | 3132351 |
| electroencephalographic manifestations of grand mal epilepsy in africans: observation of relative rarity of interictal abnormalities. | interictal eeg records of nigerian epileptic patients living in lagos and clearly diagnosed as having grand mal epilepsy were compared with those of british epileptic patients with a similar diagnosis. interictal eeg abnormalities (spike and wave discharges, (sw), photoparoxysmal discharges (ppd), and nonspecific changes) were significantly less common in nigerian patients (incidence 15.7%) compared with british patients (incidence 52.9%) irrespective of age or sex of the patients. these finding ... | 1988 | 3134191 |
| case of disseminated african histoplasmosis in a baboon. | an adult red baboon (papio cynocephalus papio) had a severe disseminated case of african histoplasmosis (histoplasma capsulatum var. duboisii) with skin lesions from small pustules to ulcerative granulomas. osteolytic lesions were seen radiographically. treatment with ketoconazole for 6 months was unsuccessful. | 1988 | 3184166 |
| epileptic discharges induced by intermittent light stimulation in photosensitive baboons: a current source density study. | the current source density (csd) method was applied to the study of paroxysmal discharges (pds) induced by intermittent light stimulation (ils) in papio papio baboons made photosensitive by a subconvulsant dose of allylglycine. csd was studied in the motor and premotor areas (4 and 6). laminar profiles of sinks and sources are similar in both areas. nevertheless, the motor area seems to become involved first since it shows the earliest and most prominent sink in layer iii. such a sink, correlate ... | 2013 | 3197674 |
| photic epilepsy problems raised in man and animals. | the data gathered in 30 years' study in man and in several animal species, but especially in the papio papio baboon, tend to show that the cortex plays a decisive part in the seizure and interval discharges induced by intermittent light stimulation in photic epilepsy. two regions of the cortex predominate: the frontorolandic and occipital regions. the cortical cortex can, indeed, transmit or control the visual input to the frontorolandic region and can cause intermittent discharges in certain sp ... | 1987 | 3323124 |
| seed-eating by west african cercopithecines, with reference to the possible evolution of bilophodont molars. | data on tooth use in eating fruits and seeds were collected on 12 west african monkeys representing five species of cercopithecines, cercopithecus aethiops, cercopithecus campbelli, cercocebus atys, erythrocebus patas, and papio papio. field observations and information in the published literature were used to select fruits for captive feeding trials. a total of over 27,000 tests were conducted to determine the preferences of the monkeys for 78 fruits. data were collected on the selection of fru ... | 1988 | 3364545 |
| gaba-containing neurons in the pontine nuclei of rat, cat and monkey. an immunocytochemical study. | putative gabaergic elements in the pontine nuclei have been studied in the rat, cat and two old world monkeys (macaca mulatta and papio papio) using an antiserum against gaba-glutaraldehyde-protein conjugates and the peroxidase-antiperoxidase method. in addition, an antiserum against glutamate decarboxylase has been used in the cat. for comparison, golgi impregnated material from cat and macaque has been studied. in all species there is a moderately dense plexus of fibres with gaba-like immunore ... | 1988 | 3393281 |
| [type b myoclonus in papio papio: results of the central anticholinergic effect of benzodiazepines]. | 1987 | 3427649 | |
| [neurotoxicity and cardiotoxicity of bupivacaine on the papio papio baboon]. | 1987 | 3434894 | |
| new gene assignments and syntenic groups in the baboon (papio papio). | mdh2, sod2, peps, and itpa were assigned to papio papio chromosomes 3, 4, 5, and 10, respectively, by their concordant segregation with previously assigned gene markers in a set of baboon x mouse somatic cell hybrids. the linkage of np, idh2, sord, mpi, and pkm2 was confirmed, and three other independently segregating markers (mdh1, acy1, and pepb) were identified. syntenic groups described in the baboon are compared to those found in man and in the rhesus monkey. | 1986 | 3459637 |
| [myoclonia. from the myoclonia of papio papio to various human myoclonias]. | the baboon papio papio is naturally predisposed to present several types of myoclonus, the study of which can help in understanding the various human myoclonic symptomatologies. the three types of myoclonus which are studied have been called a, b and c. myoclonus a, which is induced by intermittent photic stimulation in photosensitive animals, is of epileptic nature: it is always preceded by spikes-waves predominating in the fronto-rolandic cortex (areas 4 and 6) and can be followed by secondari ... | 1986 | 3518016 |
| extracellular calcium and potassium concentration changes in chronic epileptic brain tissue. | repetitive electrical stimulation and application of excitatory amino acids lead to decreases in extracellular ca2+ concentration and to rises in extracellular k+ concentration [( ca2+]o, [k+]o) with a typical laminar distribution in a given neo- or allocortical structure. these ionic changes result from transmembrane ion fluxes along their respective electrochemical gradients. epileptogenic drugs that impair repolarizing k+ conductances or inhibitory synaptic transmission enhance such extracell ... | 1986 | 3518350 |
| the role of visual reafferents during a pointing movement: comparative study between open-loop and closed-loop performances in monkeys before and after unilateral electrolytic lesion of the substantia nigra. | in order to elucidate the compensatory role of visual feedback during movement, two experiments were designed to compare the motor performances of papio papio baboons depending on whether the animals were able to visually control the limb trajectory (visual closed-loop condition) or not (visual open-loop condition). the visuomotor task used consisted of making trained pointing movements towards a stationary target. in experiment a, the baboons were successively presented with these two experimen ... | 1987 | 3556467 |
| glycine-like immunoreactivity in the cerebellum of rat and senegalese baboon, papio papio: a comparison with the distribution of gaba-like immunoreactivity and with [3h]glycine and [3h]gaba uptake. | an antiserum against conjugated glycine was characterized and applied to cerebellar sections of rats and baboons that had been perfusion-fixed with glutaraldehyde. after immunosorbent purification the serum reacted with brain protein-glutaraldehyde-glycine conjugates, but did not stain similar test conjugates prepared from other amino acids, including gaba and beta-alanine. in the rat cerebellum the glycine antiserum selectively labelled a subpopulation of golgi neurons. adjacent vibratome secti ... | 1987 | 3582532 |
| spontaneous hand usage and handedness in a troop of baboons. | hand usage was studied in a troop of 18 guinea baboons (10 adults and 8 young) for spontaneous activities. handedness was determined by an analysis of unimanual activities and bimanual asymmetric activities. the distribution of preferential biases gave 5 right-handers and 2 left-handers, other subjects being ambidextrous. main effects were age related: the strength of the preference was greater for adults than for young; moreover, bimanual activities performed by the adult group were more asymme ... | 1987 | 3608520 |
| reciprocal inhibition between seizures induced by intermittent light stimulation and premotor cortical stimulation in senegalese baboons, papio papio. | the temporal relationship between the degree of photosensitivity and the intensity of kindling stimulus response was examined in four senegalese baboons, papio papio, kindled at the premotor cortical area. when fully kindled, the intensity of photosensitivity diminished significantly in all the animals. with successive daily intermittent light stimulation, two animals showed partial recovery and the other two showed complete recovery to the prekindling level of photosensitivity. when premotor co ... | 2006 | 3691413 |
| the influence of light stimulation on subcortical potentials evoked by single flashes in photosensitive papio papio. | visual evoked potentials (veps) from the frontorolandic (fr) cortex and from subcortical nuclei (colliculi superioris, pulvinar, corpori geniculati lateralis, centrum medianum, ventralis lateralis) and from pontine reticular formation were analyzed in papio papio monkeys rendered photosensitive by a subconvulsant dose of allylglycine. the veps induced by single flashes were compared statistically with those induced by flashes preceded by trains of intermittent light stimulation (ils). this latte ... | 1986 | 3948815 |
| synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy. | a series of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines derivatives was synthesized and evaluated for anticonvulsant activity. the compounds were screened in mice for their ability to antagonize maximal electroshock- and bicuculline-induced seizures; neurotoxicity was evaluated in the rotorod test. the anticonvulsant activity of the most potent compounds in this series was also examined in kindled amygdaloid rats and in photoepileptic papio papio baboons. phenobarbital, diphenylhydantoin, ca ... | 1986 | 3950916 |
| anticonvulsant action of 1,3-dimethyl-5-aminoadamantane. pharmacological studies in rodents and baboon, papio papio. | the anticonvulsant actions of memantine (1,3-dimethyl-5-aminoadamantane) have been evaluated in mice (seizures induced by maximal electroshock, pentylenetetrazol, bicuculline, picrotoxin, 3-mercaptopropionic acid and n-methyl-d,l-aspartic acid) and in photosensitive baboons, papio papio (clonic responses to intermittent photic stimulation). memantine, 5-20 mg/kg, raised the threshold for electroconvulsions and protected mice against the tonic hind limb extension in pentylenetetrazol-, bicucullin ... | 1986 | 3951570 |
| [hypofunction of the central cholinergic neurons is the cause of stimulus-sensitive myoclonus in the baboon papio papio]. | 1986 | 3955725 | |
| distribution of central cholinergic neurons in the baboon (papio papio). i. general morphology. | the morphological characteristics of cholinergic neurons in the central nervous system (cns) of the baboon (papio papio) were studied by choline acetyltransferase (chat) immunohistochemistry and acetylcholinesterase (ache) pharmacohistochemistry. the distributions of central cholinergic neurons as visualized by these two histochemical techniques were similar in most, but not all regions of the brain and spinal cord. based upon these observations, central cholinergic neurons that are immunoreacti ... | 1985 | 4056094 |
| distribution of central cholinergic neurons in the baboon (papio papio). ii. a topographic atlas correlated with catecholamine neurons. | the topographic distribution of central cholinergic and catecholaminergic neurons has been investigated in the baboon (papio papio). the perikarya were mapped on an atlas through the brain and spinal cord employing sections processed for acetylcholinesterase (ache) pharmacohistochemistry coupled with choline acetyltransferase (chat) immunohistochemistry or aqueous catecholamine-fluorescence histochemistry. compared with subprimates, there is a remarkable increase in the volume occupied by and th ... | 1985 | 4056095 |
| serum anticonvulsant levels during chronic administration in the immature epileptic baboon, papio papio. | 1985 | 4070243 | |
| photic and drug-induced epilepsy in the baboon (papio papio): the effects of isoniazid, thiosemicarbazide, pyridoxine and amino-oxyacetic acid. | 1970 | 4097203 | |
| preliminary study of the effect of high pressures in oxygen-helium atmospheres on papio papio. | 1971 | 4103153 | |
| changes in visual evoked potentials and in photosensitivity produced by lsd in papio papio. | 1971 | 4103166 | |
| preliminary studies of the electrical changes following section of the corpus callosum in photosensitive papio papio. | 1971 | 4103167 | |
| [behavioral and electrographic effects of d-lysergic acid diethylamide (lsd 25) on the photosensitive papio papio]. | 1971 | 4103501 | |
| frequent attacks and anatomical lesions in the photosensitive papio papio. | 2012 | 4103565 | |
| effects of psilocybin, dimethyltryptamine, mescaline and various lysergic acid derivatives on the eeg and on photically induced epilepsy in the baboon (papio papio). | 1971 | 4111479 | |
| [effect of p-chlorophenylalanine on sleep in the baboon papio papio]. | 1972 | 4113280 | |
| behavioural and electrographic effects of l-5-hydroxytryptophan and d, l-parachlorophenyl-alanine on epileptic senegalese baboon (papio papio). | 1972 | 4116436 | |
| chronic epileptogenic foci in the photosensitive baboon, papio papio. | 1973 | 4120310 | |
| [section of the facial nerves and the periocular muscles in the photosensitive papio papio]. | 1973 | 4123260 | |
| [similarities and differences in the sleep of 2 baboons, papio hamadryas and papio papio]. | 1973 | 4124615 | |
| a study of the periocular projections towards the frontal cortex in papio papio. | 2014 | 4129628 | |
| the influence of thyroxine in photosensitive baboons papio papio. | 1974 | 4130603 | |
| [differential effects of p-chlorophenylalanine on sleep in primates, papio papio and papio hamadryas]. | 1974 | 4135023 | |
| [a specific striated muscle antigen of papio papio monkey (author's transl)]. | 1973 | 4143159 | |
| studies on the epilepsy induced by photic stimulation in papio papio. | 1967 | 4165608 | |
| preliminary results of an eeg study of the effects of hyperbaric treatment of experimental carotid gas embolism in papio papio. | 1967 | 4169852 |