Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| photically-induced epilepsy and glucose metabolism in the adolescent baboon (papio papio). | 1970 | 5511226 | |
| convulsive effects of 4-deoxypyridoxine in photosensitive baboons (papio papio). | 1971 | 5572301 | |
| [photosensitive epilepsy in the baboon papio papio: clinical and electroencephalographic (cortex and deep structures) study]. | 1968 | 5700027 | |
| [enumeration of keratinophilic fungi in a population of cynocephalus monkeys (papio papio)]. | 1966 | 5987836 | |
| gabaergic agents as anticonvulsants in baboons with photosensitive epilepsy. | gabaergic agents have been evaluated for acute anticonvulsant activity in baboons, papio papio with photosensitive epilepsy. the potent gabaa agonists muscimol and thip are proconvulsant. (-)baclofen, 2 mg/kg suppresses myoclonic responses; higher doses facilitate eeg paroxysmal activity. (s) gamma-vinyl gaba, 100-200 mg/kg, suppresses myoclonic responses for more than 24 h. some derivatives of esters of beta-carboline-3-carboxylate that bind to the benzodiazepine receptor, e.g. zk 91296 and zk ... | 1984 | 6089055 |
| conservation of the human col1a1-tk-gaa synteny and homoeologous assignment in the african green monkey and the baboon (cercopithecoidae). | the pro alpha 1 (i) collagen structural gene (col1a1), the acid alpha-glucosidase (gaa), and the thymidine kinase (tk) genes, known to be closely linked in man (hsa) and mapped to hsa17, were found syntenic in two cercopithecoidae species, the baboon (papio papio, ppa) and the african green monkey (cercopithecus aethiops, cae) and assigned to homoeologous chromosomes, ppa16 and cae19, respectively. the assignment of col1a1 was obtained using two human cdna probes. hind iii restriction sites foun ... | 1984 | 6096258 |
| gamma-glutamyl transferase distribution in the organs of papio papio and macaca fascicularis. | tissue distribution of non solubilized gamma-glutamyl transferase (ggt) was studied in eight baboons and ten macaques. in both, ggt is mainly in kidney, pancreas and liver. this tissue distribution of ggt is roughly similar to that observed in man. | 1980 | 6107384 |
| [myoclonus induced by some benzodiazepines in the papio papio. comparison with myoclonus induced by intermittent light stimulation (author's transl)]. | papio papio may show two different kinds of myoclonus. a first type corresponds to myoclonus induced by photic stimulation (25 hz). this type is always preceded by paroxysmal discharges. another type of myoclonus may be induced, or at least facilitated, by some benzodiazepines, especially lorazepam and, to a lesser extent, diazepam. this type is neither preceded nor accompanied by paroxysmal discharges. a single injection of lorazepam (1 mg/kg i.v.) blocks the first type of myoclonus but favors ... | 1982 | 6125000 |
| differential effects of the benzodiazepine antagonist ro 15-1788 on two types of myoclonus in baboon papio papio. | certain benzodiazepines (bzs) like lorazepam, diazepam or clonazepam induce myoclonus jerks in photosensitive and non-photosensitive baboons. papio papio, which are not accompanied by eeg paroxysmal discharges (type b). the effect of the selective bz antagonist r0 15-1788 was evaluated in this myoclonus. ro 15-1788 completely blocked type b myoclonus without decreasing the level of vigilance in the two types of baboons, and reversed the antiepileptic action of the bzs in the photosensitive ones, ... | 1983 | 6136945 |
| antiepileptic action of excitatory amino acid antagonists in the photosensitive baboon, papio papio. | antagonists of excitation induced by dicarboxylic amino acids have been evaluated for acute anticonvulsant activity in baboons, papio papio, with photosensitive epilepsy. 2-amino-7-phosphonoheptanoic acid, 1 mmol/kg, i.v., abolishes myoclonic responses for 5 h. less prolonged protection is seen after cis-2,3-piperidine-dicarboxylic acid, 1-3.3 mmol/kg; 2-amino-5-phosphonovaleric acid, 1-3.3 mmol/kg; or glutamic acid diethyl ester, 1-3.3 mmol/kg. toxic side-effects are prominent after the latter ... | 1983 | 6138738 |
| evidence for neurotransmitter abnormalities related to seizure activity in the epileptic baboon. | the experimental evidence that indicates that alterations in neurotransmitter activity exacerbate or diminish seizure responses to intermittent light stimulation in the papio papio model of epilepsy is reviewed. studies of the effects of drugs known to modify the synthesis, storage release, or activity of known or putative neurotransmitters are included. catecholamines, to a lesser extent the indolamine, serotonin, and the inhibitory transmitter gamma-aminobutyric acid all alter seizures as do l ... | 1984 | 6145626 |
| eeg and anticonvulsant effects of dipropylacetic acid and dipropylacetamide in the baboon papio papio. | the ability of dipropylacetic acid (dpa) and dipropylacetamide (dpm) to modify eeg and seizure activity was assessed in 4 female and 3 male papio papio. doses of 30-60 mg/kg of dpa given at intervals over an 8 h period produced blood levels of 19-44 micrograms/ml which were not protective against intermittent light stimulation (ils). administration of 150-200 mg/kg doses at intervals over a 36 h period produced blood levels greater than 150 micrograms/ml and were highly protective against ils. s ... | 1980 | 6158417 |
| paroxysmal visual evoked potentials (pveps) in papio papio. i. morphological and topographical characteristics. comparison with paroxysmal discharges. | 1980 | 6160979 | |
| paroxysmal visual evoked potentials (pveps) in papio papio. ii. evidence for a facilitatory effect of intermittent photic stimulation. | 1980 | 6160980 | |
| cerebral and extracerebral blood volume in generalized seizures in the baboon papio papio. | relative variations of the cerebral and extracerebral blood volume (cbv) were measured continuously by a novel atraumatic method in baboons to explore the relationship between changes in the systemic circulation and in the cerebral (and extracerebral) vascular responses, before, during and after generalized seizures induced by photic stimulation. major bursts of generalized spikes and waves are accompanied by an increase of the mean arterial pressure and of the cerebral blood volume and a decrea ... | 1981 | 6161785 |
| cortical unit activity during intermittent photic stimulation in papio papio. relationship with paroxysmal fronto-rolandic activity. | extracellular records have been made in the fronto-rolandic (fr), parietal and occipital cortical areas in papio papio injected with allylglycine and paralysed with a synthetic curarizing agent. the organization of the unit discharges in the absence of intermittent light stimulation (ils) is normal. during ils, unit discharges in the fr cortex are organized in bursts of high frequency that are synchronous with the spikes of the eeg paroxysmal discharges (pd) in the same territory; this burst-org ... | 1981 | 6166452 |
| opposite effects of lorazepam on two kinds of myoclonus in the photosensitive papio papio. | the action of lorazepam was studied in photosensitive baboons. animals were either naturally very photosensitive or rendered photosensitive by a previous injection of allylglycine. intravenous administration of varying doses, from 0.05 to 0.5 mg/kg, of lorazepam blocked the myoclonus induced by intermittent light stimulation in all the animals. however, in the naturally photosensitive baboon the injection of lorazepam favoured the appearance of spontaneous myoclonus with no important eeg modific ... | 1981 | 6172264 |
| characteristics and origin of frontal paroxysmal responses induced by light stimulation in the papio papio under allylglycine. | in the papio papio, curarized and rendered photosensitive by injection of a subconvulsant dose of dl-allylglycine, single flashes induce frontal paroxysmal evoked responses on condition that they be preceded by trains of intermittent light stimulation (ils). the characteristics of these responses have been compared to those of non-paroxysmal responses induced in the same cortical area by isolated flashes (not preceded by trains of ils). the paroxysmal responses resemble spikes and waves and cons ... | 1982 | 6177492 |
| the effects of constant light on eeg and seizure activity in the epileptic baboon. | the effects of a change from a standard photoperiod (12:12 ld, 45 fc) to that of constant low level illumination (ll, 5 fc) on electroencephalographic activity (eeg), photic seizures and urine cortisol excretion were investigated in the baboon papio papio. unlike the normal circadian cycle, in which maximal urine cortisol excretion occurred at 08.00 h and minimal at 20.00 h, rhythms in cortisol excretion were free running under constant light, shifting an average of 2 h/week toward an earlier ti ... | 1982 | 6179743 |
| limbic status epilepticus: behaviour and sleep alterations after intra-amygdaloid kainic acid microinjections in papio papio baboons. | limbic status epilepticus was produced with single microinjections of kainic acid in the amygdala of baboons (papio papio). long-term studies of the behavioural, electrographic and sleep alterations were performed. during status epilepticus the animals did not display aggressive behaviour. feeding behaviour was diminished. sleep was also deeply disturbed. wakefulness was greatly increased, light slow wave sleep was diminished and deep slow wave sleep and paradoxical sleep was abolished. sleep al ... | 1982 | 6183093 |
| speciation in the baboon and its relation to gamma-chain heterogeneity and to the response to induction of hbf by 5-azacytidine. | in the baboon (papio species), the two nonallelic gamma-genes produce gamma-chains that differ at a minimum at residue 75, where isoleucine (i gamma-chain) or valine (v gamma) may be present. this situation obtains in baboons that are sometimes designated as papio anubis, papio hamadryas, and papio papio. however, in papio cynocephalus, although the i gamma-chains are identical with those in the above mentioned types, the v gamma-chains have the substitutions ala----gly at residue 9 and ala----v ... | 1984 | 6201212 |
| the influence of intermittent light stimulation on potentials evoked by single flashes in photosensitive and non-photosensitive papio papio. | the effects of intermittent light stimulation (ils) on visual potentials (veps), evoked in different cortical areas, were statistically studied in baboons either naturally photosensitive or made photosensitive by allylglycine at a subconvulsant dose, as well as in non-photosensitive animals. veps were induced by single flashes (paradigm a) or by flashes preceded by trains of ils (paradigm b). in every baboon, photosensitive or not, the veps induced by paradigm b in the striate area show a decrea ... | 1984 | 6201340 |
| dna sequence of baboon highly repeated dna: evidence for evolution by nonrandom unequal crossovers. | a highly repeated dna was isolated from the west african baboon (papio papio) as a 343-base-pair fragment after digestion of total baboon dna with the restriction endonuclease bamhi. the dna sequence of this fragment was obtained by chemical cleavage methods and is compared with the dna sequence of related highly repeated primate dnas from african green monkey (cercopithecus aethiops) and man. the 343-base-pair baboon repeat consists of two related but nonidentical wings of 172 and 171 base pair ... | 1980 | 6246524 |
| silent delta-globin gene in old world monkeys. | the delta polypeptide chain is present in the adult hemoglobin of all higher primates except old world monkeys. because old world monkeys have evolved from higher primate ancestors, it can be concluded that the ability to synthesize this polypeptide has been lost relatively recently. it is shown here that the gene for delta globin exists in two of these species, the rhesus monkey (macaca mulatta) and the baboon (papio papio). restriction endonuclease fragments of monkey genomic dna bearing the d ... | 1980 | 6251467 |
| sustained limbic seizures induced by intraamygdaloid kainic acid in the baboon: symptomatology and neuropathological consequences. | in papio papio baboons chronically prepared for cortical and deep electroencephalographic recording, injection of kainic acid into the amygdala (7 animals) or temporal pole (2 animals) gave rise to focal epileptic discharges lasting 15 to 150 hours. electrographically, the seizure activity spread ipsilaterally and contralaterally within the limbic system but did not become generalized. the principal associated motor signs were arrest of movement and oral automatisms. histological examination aft ... | 1980 | 6254439 |
| assessment of cell-mediated immunity against coxsackievirus b3-induced myocarditis in a primate model (papio papio). | delayed hypersensitivity and myocarditis were induced in five baboons (papio papio) after inoculation with myocarditic murine coxsackievirus b3 (cvb3m). by means of the [3h]thymidine incorporation assay and the agarose droplet cell migration inhibition assay, specific cell-mediated immunity was detected in all five animals against viral antigens and/or kcl-extractable soluble antigens extracted from the heart of a cvb3m-inoculated baboon. kcl-extracted antigens from normal baboon heart tissues, ... | 1981 | 6260666 |
| naturally occurring yaba tumor in a baboon (papio papio). | 1981 | 6267372 | |
| anticonvulsant action in the photosensitive baboon, papio papio, of a novel beta-carboline derivative, zk 91296. | the anticonvulsant action of ethyl-5-benzyloxy-4-methoxymethyl-beta-carboline-3-carboxylate (zk 91296) has been studied in senegalese baboons, papio papio, with photosensitive epilepsy. myoclonic and paroxysmal electroencephalographic responses to stroboscopic stimulation are diminished or abolished for 2-4 h after zk 91296, 0.25-4 mg/kg, i.v. radioreceptor assay of plasma zk 91296 indicates rapid clearance (t 1/2 alpha, 5-20 min and beta, 60-90 min). in this model of generalised epilepsy zk 912 ... | 1983 | 6311579 |
| anticonvulsant actions of ds 103-282. pharmacological studies in rodents and the baboon, papio papio. | the anticonvulsant actions of ds 103-282 [5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3- benzothiadazole , tizanidine], have been evaluated after intraperitoneal administration in dba/2 mice (seizures induced by sound), in swiss s mice (seizures induced by n-methyl-d,l-aspartate; nmdla ) and following intravenous or oral administration in papio papio (seizure responses to intermittent photic stimulation). protection against sound-induced seizures occurred after intraperitoneal administration of ds ... | 1984 | 6377114 |
| comparative assessment of dopamine agonist aporphines as anticonvulsants in two models of reflex epilepsy. | the anticonvulsant action of various aporphine derivatives that act on dopamine receptors has been investigated in two genetically determined animal models--dba/2 mice with sound-induced seizures and baboons papio papio with photically-induced seizures. protection against the clonic and tonic phases of the seizures response in dba/2 mice was seen for 15-60 min after (-)2,10,11-trihydroxy-n-n-propylnoraporphine (1.25 mg/kg) and (-)10,11-methyl-enedioxy-n-n-propylnoraporphine (0.625-1.25 mg/kg) an ... | 1983 | 6415743 |
| action of suriclone in naturally and allyglycine-induced photosensitive baboons, papio papio. | suriclone (sc) is a new anxiolytic compound with a chemical structure different from that of benzodiazepines (bzd) but sc possesses a high affinity for the so-called bzd receptors. sc was tested in the naturally or the allylglycine-treated photosensitive baboon papio papio. as active bzd administered by the intramuscular or oral route, this new compound possesses a marked protective effect against the excessive photosensitivity of the baboons, it blocks myoclonus following eeg spike and waves di ... | 1984 | 6436048 |
| dental microwear and mechanisms in early hominids from laetoli and hadar. | the dentition of early hominids from laetoli and hadar provide evidence of "incisal stripping" and a shear-grinding action for c/p3 complex through microscopic examination of wear facets on dental crowns. this masticatory pattern of dental wear resembles that of papio papio and suggests behavioral analogies between early hominids and papio. | 1984 | 6437237 |
| heterogeneity of hepatic microsomal udp-glucuronosyltransferase(s) activities: comparison between human and mammalian species activities. | the first comparative profiles of udp-glucuronosyltransferase(s) (udpgt) activities obtained under standard conditions in vitro in mammals (man, rat [wistar and gunn], mouse, monkey [papio papio and cynomolgus], pig, guinea pig, rabbit, dog) are presented for 16 aglycones. a decreasing scale of these activities was obtained from planar to bulky molecules. the scale was identical for each of the mammals studied, including man. statistical analysis of the results revealed a division of the aglycon ... | 1984 | 6439424 |
| genetic animal models of epilepsy as a unique resource for the evaluation of anticonvulsant drugs. a review. | genetic animal models of epilepsy comprise genetically predisposed animal species in which seizures either occur spontaneously or in response to sensory stimulation. the major advantage of these naturally occurring epilepsies in animals as models of human epilepsy is that they simulate the clinical situation more closely than any other experimental epilepsy. models with idiopathic spontaneous recurrent seizures are epileptic dogs, tottering mice, and rats with spike-wave absence (petit mal) seiz ... | 1984 | 6439966 |
| effects of addition of nitrogen during rapid compression of baboons. | a series of dives was carried out to depths of 600 and 800 m seawater (msw) using baboons (papio papio). experiments were designed to study the effects of compression and the use of a he-n2-o2 gas mixture on high-pressure nervous syndrome (hpns). when n2 was added to the he-o2 mixture at the beginning of a linear compression (200 msw/h), the symptoms associated with hpns were still seen; in addition, the electroencephalogram (eeg) changes were more severe than those seen without n2. by use of an ... | 1984 | 6469803 |
| hpns of baboons during helium-nitrogen-oxygen slow exponential compressions. | from the results obtained with the experimental series corasin (fast compression with he-n2-o2), a method of compression has been developed for the baboon (papio papio) to dive deeper than 600 m. this method utilizes an exponential compression profile with stages of 40 min every 100 m and with the introduction of n2 before each stage from 200 m onward to maintain a concentration of 5.5%. between 0 and 800 m, this procedure did not produce myoclonus or epileptic seizures; tremor appeared beyond 4 ... | 1984 | 6469804 |
| behavioural and convulsant actions of two methyl esters of beta-carboline-3-carboxylic acid in photosensitive baboons and in dba/2 mice. | the proconvulsant and convulsant actions of methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (dmcm) and of methyl-beta-carboline-3-carboxylate (beta-ccm) have been evaluated in two animal models of reflex epilepsy, the photosensitive baboon, papio papio, and the audiogenic seizure prone dba/2 mouse. in baboons, myoclonic responses to photic stimulation are markedly enhanced 1 min after dmcm, 0.25 mg/kg i.v. in the absence of photic stimulation dmcm, 0.5 mg/kg i.v. induces a single brief ... | 1984 | 6499918 |
| [connections of the laterodorsal nucleus of the thalamus in the monkey. study of efferents]. | efferent pathways of the ld nucleus of the thalamus were studied in 6 papio-papio baboons with the retrograde transport technique utilizing hrp. injections were made in cingular and parietal cortex and hippocampal formation. large projection from the ld to the cingular and subicular cortex were visualized as reciprocal connections. no pathway to parietal area 7 was found. the course of the fibers is via the fornix, the cingular bundle and the retro-lenticular portion of the internal capsule. the ... | 1984 | 6505490 |
| physostigmine antagonizes benzodiazepine-induced myoclonus in the baboon, papio papio. | the antagonism of some benzodiazepine (bz) actions by physostigmine was investigated in 4 papio papio baboons. as a model of these actions, the myoclonus induced in this species by clonazepam i.m. administration was used. the baboon develops, 20-30 min after bz i.m. injection, a non-epileptic myoclonus characterized by clinical symptomatology (jerks involving mainly the neck and the trunk bilaterally), by the absence of any correlative eeg discharge, and by its facilitation during movement. this ... | 1984 | 6527840 |
| amygdaloid kindling in papio cynocephalus and subsequent recurrent spontaneous seizures. | three baboons, papio cynocephalus, (two photosensitive and one nonphotosensitive) were subjected to amygdaloid kindling. electroclinical profile of seizure development-developed seizure compares very favourably to that described in photosensitive baboons, papio papio, with rapid seizure progression and ultimate emergence of stage 5 bisymmetrical and bisynchronous generalized convulsive state. in addition, one baboon developed spontaneous recurrent seizures which were identical to the kindled sta ... | 1984 | 6532930 |
| new gene assignments in the baboon and new chromosome homoeologies with man. | eight new gene assignments were demonstrated in the baboon (papio papio, ppa) by cosegregation analysis of twelve hybrid clones obtained by fusion between ppa fibroblasts and a mouse cell line deficient in thymidine kinase. the following markers and syntenic groups were assigned: sod1 to ppa3, glo-me1 to ppa-4, pgm2 to ppa5, ckbb-sord to ppa7, ldhb to ppa11 and ldha to ppa14. these localizations are in agreement wit hthe following homoeologies with the human karyotype: ppa3-hsa21, ppa4-hsa6, ppa ... | 1983 | 6604489 |
| heredofamilial retinal dystrophy in guinea baboons. i. a histopathologic study. | we performed a histopathologic study of a heredofamilial retinal dystrophy in a colony of guinea baboons. a bull's-eye appearance was noted in the maculas of six baboons of three generations. histologic examination of 13 eyes from this colony showed primary degeneration of both rod and cone cells initially in the parafoveal region, which subsequently involved the photoreceptor cells of the equator and periphery of the retina. the retinal pigment epithelium and choriocapillaris showed mild change ... | 1983 | 6626015 |
| [thymosin-testosterone interaction in spontaneous rosette formation in the baboon monkey (papio papio)]. | thymosine fraction v was shown to exert a stimulation activity on t lymphocytes from papio papio, as determined by e. rosette and active e. rosette formation. testosterone inhibited this effect of thymosin. | 1983 | 6627910 |
| heredofamilial retinal dystrophy in guinea baboons. ii. electron microscopic observations. | electron microscopic study of an inherited retinal degeneration in guinea baboons disclosed primary pathologic alterations in photoreceptor cells. these changes were first seen in the perifoveal region. cell death occurred in two forms: hydropic degeneration and densification and/or necrosis. the hydropic type was mainly associated with cone cells, whereas densification and/or necrosis was largely seen in rod cells. lamellar bodies and granular membrane-bound inclusions were noted in the inner s ... | 1983 | 6639434 |
| naloxone reversal and morphine exacerbation of neurologic deficits secondary to focal cerebral ischemia in baboons. | the effects of an opiate agonist (morphine) and antagonist (naloxone) on neurologic function in conditions of acute and subacute focal cerebral ischemia were tested in a baboon model. fourteen baboons (papio papio) underwent unilateral transorbital microsurgical occlusion of the middle cerebral artery (mca). blood pressure, heart rate and core temperature were monitored continuously; frequent arterial blood gas measurements were made. cardiac output, cardiac filling pressures, and regional cereb ... | 1984 | 6692145 |
| limbic kindling in the forebrain-bisected photosensitive baboon, papio papio. | when forebrain-bisected photosensitive baboons, papio papio, were kindled from the amygdala or hippocampus, bilateralization of convulsive seizure proved difficult, and the final stage of bisymmetrical and bisynchronous convulsive seizure unique to this species did not develop despite more than twice the number of kindling stimulations required for its development in nonbisected baboons. at the secondary site amygdala, convulsive seizure development was suppressed. findings of the present and pr ... | 1984 | 6723588 |
| effects of the bicyclic gaba agonist, thip, on myoclonic and seizure responses in mice and baboons with reflex epilepsy. | thip, 4,5,6,7-tetra hydroisoxazolo[5,4-c]pyridine-3-ol, has been evaluated as an anticonvulsant in dba/2 mice showing audiogenic seizures, and in baboons, papio papio, with photosensitive epilepsy. no protection against seizures was seen after thip, 1-4 mg/kg, intraperitoneally in mice. thip, 8 mg/kg, reduced clonic and subsequent seizure responses at 1 h. it also reduced rectal temperature and impaired posture and spontaneous activity. in baboons thip, 0.25-8 mg/kg, iv, failed to protect agains ... | 1980 | 6767614 |
| proteoglycan populations of baboon (papio papio) cartilages from different anatomical sites: gel electrophoretic analysis of dissociated proteoglycans and of fractions obtained by density gradient centrifugation. | proteoglycans extracted by 4 m guanidinium chloride from different cartilages and vertebral discs of young baboons (papio papio) were purified by ion-exchange chromatography and assessed by gel electrophoresis. proteoglycans fractionated by equilibrium density gradient centrifugation under 'dissociative' conditions were similarly purified and assessed. (1) non-fractionated proteoglycans from articular, nasal, laryngeal, tracheal, costal, vertebral plate and ear cartilage and from anulus fibrosus ... | 1980 | 6770906 |
| circadian periodicity of brain activity and urinary excretion in the epileptic baboon. | a 24-h rhythm in the proclivity of the baboon papio papio to exhibit a seizure response to intermittent light stimulation (ils) has been uncovered. seizure response to ils was found to be greatest in the morning at about 0900 h, 2 h after lights on, and least severe in the evening at about 2000 h 1 h after lights off. urine cortisol and potassium excretion rhythms followed the same pattern as seizure susceptibility and sodium rhythms were 3 or 4 delayed. mean values for urine cortisol per 4 h ra ... | 1980 | 6772040 |
| anticonvulsant and proconvulsant properties of viloxazine hydrochloride: pharmacological and pharmacokinetic studies in rodents and the epileptic baboon. | viloxazine hcl is evaluated as an anticonvulsant in a wide range of rodent seizure models and in the epileptic baboon (papio papio). in the maximal electroshock test, the oral ed50 for abolition of tonic extension was 9 mg/kg-1 after 30-min pretreatment (mouse) rising to 30 mg/kg-1 after 60 min (mouse and rat). comparable ed50 values were also found for protection against tonic extension in the mouse induced by the administration of the chemical convulsants metrazole or 3-mercaptopropionic acid. ... | 1982 | 6808538 |
| [consequences of pulpectomy followed by canal obturation on the renewal of periodontal ligament in the baboon (papio papio)]. | endodontic root filling following pulpectomy in baboons was shown to induce diphasic consequences at the level of the periodontal ligament according to the time of the observation. initially the specific activity of previously incorporated 3h glycine decreased and the weight of extractible ligament increased at the same time. later on, the turnover slowed down and, unexpectedly, the weight of the extractible ligament decreased. this could be explained since the periodotal ligament was shown to e ... | 1982 | 6812879 |
| cerebellar control of eye movements studied with injection of harmaline in the trained baboon. | 1. the alteration of the cortical cerebellar mechanisms resulting from the activation of the olivo-cerebellar pathway by harmaline (h) administered at doses which were subthreshold for skeletomotor tremor (5 mg/kg, im) yields, in the trained baboon (papio papio), a marked decrease of oculomotor system performance. 2. the mean angular excursion of the spontaneous eye movements produced in the dark over a given period of time is increased by 50%. the increase is basically due to an increase of the ... | 1983 | 6847319 |
| noradrenergic regulation of growth hormone secretion in the baboon. | we have investigated the effects of iv administered noradrenergic agonists and antagonists on plasma gh concentration in the adolescent baboon, papio papio, with the aim of defining the relative roles of adrenergic receptor subtypes (alpha 1, alpha 2, beta 1, and beta 2) in the regulation of gh release. clonidine (0.02 mg/kg) or uk-14,304 (0.02 mg/kg), potent centrally acting alpha 2 noradrenergic agonists, were infused into 24 animals pretreated with either saline, or selective alpha 1 and alph ... | 1983 | 6847820 |
| cerebellar nuclear topography of simple and synergistic movements in the alert baboon (papio papio). | movements elicited by the stimulation of the cerebellar nuclei were studied in alert baboons chronically prepared. the motor responses were filmed and recorded in eight muscles through chronically implanted electrodes. two types of motor effects were observed: (1) simple movements that concerned the unidirectional displacement of a limb segment. (2) complex movements that involved distinct and frequently noncontiguous muscles were stereotyped and could not be dissociated. these movements are def ... | 1982 | 6889975 |
| comparative gene mapping of the baboon (papio papio) and man. | seven new gene assignments were demonstrated in the baboon (papio papio) by cosegregation analysis of twelve cell hybrids obtained between ppa fibroblasts and a mouse cell line deficient in thymidine kinase. the following markers and syntenic groups were localized : gusb on ppa3 ; np-mpi-pkm2-idh2 on ppa7; ada on ppa10 and idh1 on ppa12. these results are consistent with the following homoeologies of ppa and hsa chromosomes : ppa3-hsa7 ; ppa7-hsa14 and 15 ; ppa10-hsa20 and ppa12-hsa2q | 1982 | 6979294 |
| production of 18f-labelled 2-deoxy-2-fluoro-d-glucose and preliminary imaging results. | to allow an additional approach to the study of brain metabolism in our laboratory, the synthesis of 18f-2-deoxy-2-fluoro-d-glucose (18fdg) has been adapted by the development of simple, reliable control techniques for routine use. by positron emission computed tomography, it has been established, in the baboon papio papio, that there was a correlation between an epileptic focus and an increase in glucose incorporation. on the other hand, in man, a comparison between the local glucose utilizatio ... | 1982 | 6981509 |
| okt8 human phenotype expressed by papio papio monkey lymphocytes. | the potential cross-reactivity between human and papio papio monkey lymphocyte antigens was investigated using various monoclonal antibodies specific for human t cell subsets and hla-dr antigens. monkey circulating lymphocytes expressed the okt8 antigen, specific for the suppressor/cytotoxic t cell population and the htla antigens. these reactivities were also detected on lymphoid cells in the thymus and lymph nodes of the papio monkey. | 1982 | 6982277 |
| the evoked epilepsies. | epileptic activity may be strongly influenced by events occurring outside the central nervous system. at least 6% of recurrent seizures are evoked by specific afferent stimuli, and these are reviewed. the commonest environmental stimulus is light; photosensitive epilepsy occurs not only in humans but also in the baboon (papio papio). recognition and hence avoidance of factors which evoke seizures is an important part of the management of the epilepsies. | 1982 | 7079862 |
| action of progabide in the photosensitive baboon, papio papio. | progabide is a gaba agonist which is nontoxic and crosses the blood-brain barrier. progabide was tested in naturally and allylglycine-induced photosensitive baboons (papio papio). intravenous injection of various doses (30 to 100 mg/kg) of progabide induced a protective effect against intermittent light stimulation (25 hz) in both test situations. this protection lasted 10 to 120 min. this duration was dose-dependent and was generally shorter in allylglycine-treated than in naturally photosensit ... | 1982 | 7140662 |
| transient abolition of generalized photosensitive epileptic discharge in humans by apomorphine, a dopamine-receptor agonist. | apomorphine, an agonist of dopamine receptors, blocks or significantly reduces photically induced seizures in the baboon (papio papio). we therefore studied the effect of subcutaneously administered apomorphine in 11 patients with generalized photosensitive epilepsy. visual evoked potentials were not altered by apomorphine, but in nine patients apomorphine transiently blocked the epileptic photosensitivity for an average of 45 minutes. therefore, dopaminergic mechanisms play a role in the pathop ... | 1980 | 7191513 |
| the influence of d-penicillamine treatment upon seizure activity and trace metal status in the senegalese baboon, papio papio. | reports suggesting participation of trace metals in processes of seizure initiation and propagation in humans and experimental animals prompted an investigation of the relationship between copper and zinc status and seizure activity in the senegalese baboon, papio papio. an evaluation of serum trace metal concentrations in three species of nonhuman primates revealed the presence of elevated zinc levels in p. papio moderately sensitive to photically induced seizures, compared with mildly seizure- ... | 1981 | 7205648 |
| [stereological analysis of normal papio papio liver parenchymal cells (author's transl)]. | stereological analysis of normal papio papio liver parenchymal cells has been performed according to the method of weibel (1969). the study was carried out on liver samples collected from 3 males and 3 females. sampling was done at three levels of magnification (x 250, x 5 000, x 15 000) without taking into consideration the lobular variations. the lobular stereological model included the hepatocyte, all the cellular organelles and the extra-hepatocytic space compartment. surface and volume dens ... | 1980 | 7212697 |
| experimental study on epileptogenic transference phenomena in kindled senegales baboons, papio papio. | 1980 | 7216051 | |
| [impairments in initiation and execution of a visually-guided movement in baboon during cooling or after lesion of the internal pallidal segment (author's transl)]. | in the present experiment, the participation of the internal part of the globus pallidus (gp) in the initiation and the execution of a pointing movement was investigated in four baboons (papio papio). the effects of gp exclusion on the response latency, the movement execution time and the pointing accuracy were analyzed. two different methods were used to exclude the gp. in two cases, cryogenic blockade was induced using a chronic cryoprobe, implanted contralaterally to the operant hand. two oth ... | 1981 | 7230049 |
| absence of seizure activity following focal cerebral injection of enkephalins in a primate. | baboons (papio papio) with photosensitive have been chronically prepared with guide cannulae and deep electrodes to study the effects of focal injections of opioids. in the hippocampus, amygdala and thalamus (centre median) 50--100 micrograms morphine, 20--100 micrograms met-enkephalin or 2--10 micrograms fk 33,824 do not induce local or general electrographic or motor signs of epilepsy. the acute epileptogenic effect of morphine and enkephalins observed in rats is not a general phenomenon where ... | 1981 | 7302294 |
| [the problem of the use of mercurials cosmetics in senegal (author's transl)]. | the use of skin-lightening preparations appears to be a problem for the coloured women in africa as well as for the black people in general. the mercurial creams occupy a place of choice into the most useful products for the skin depigmentation. an epidemiological study from twenty senegalese women using mercurials cosmetics has permitted to determine a mean value of 155,75 +/- 75,38 ppm hg in scalp hair while the normal level is less than 10 ppm. an experimental study was realised with monkeys ... | 1981 | 7302943 |
| [observation of a photosensitive syndrome in macaca nemestrina (author's transl)]. | out of a group of 12 m. nemestrina (originating from malaysia), 9 adults had shown clinical signs induced by ils at 25 c/sec. six of them (3 males, 3 females) were very photosensitive; however, only 2 presented eyelid and/or head jerks after the end of ils (level 4), but never a generalized seizure. tactile periorbital stimuli favoured myoclonus. in all but the two of level 4, the intensity of clinical signs varied from one day to the next. in all implanted adult macaques, spontaneous paroxysmal ... | 1981 | 7323374 |
| [modification of frontal and occipital cortical excitability provoked by trains of flashes in papio papio (author's transl)]. | the experimental conditions necessary for obtaining an evoked paroxysmal response from the frontal cortex were studied in the baboon papio papio. the trigger stimulus was comprised of an isolated flash preceded by a train of intermittent light stimulation (sli). two conditions were necessary for the appearance of paroxysmal responses: a subconvulsant dose of dl-allylglycine had to be injected at least 3 h previous to recording, and a sufficient number of sli trains had to be presented to the ani ... | 1981 | 7345487 |
| [new data from a comparative study of cerebral blood volume and eeg during epileptic seizures in papio papio (author's transl)]. | a new approach to the cerebral and extracerebral circulation phenomenon, during generalized seizure discharges (gsd) in the baboon is described. it is based upon the measurement of comparative variations of the regional blood volume (rbv) a new technique. first results demonstrate the existence of an extracerebral vascular structure of the face which is quite sensitive to the ictal phenomenon and which we have named the 'nasal region'. on the whole, when bursts of spike/waves occur the mean arte ... | 1981 | 7345492 |
| a medulloblastoma in a baboon (papio papio). | a transitional medulloblastoma was found in the cerebellum of a young female baboon. the primary lesion that permitted its discovery was papillary and retinal edema in the peripapillary zone. | 1980 | 7421118 |
| initiation of a goal-directed movement in the monkey. role of the cerebellar dentate nucleus. | the participation of the dentate nucleus (dn) in the initiation of a voluntary movement was investigated in five baboons (papio papio). in these experiments, we have analyzed the effects of excluding the dn on the latency (reaction time, rt) of a learned goal-directed movement. two techniques were for excluding the dn. in three animals, the structure was cooled with a probe, stereotaxically implanted on the side ipsilateral to the active hand. in two others, a partial electrolytic destruction of ... | 1980 | 7428885 |
| calcification of thymic hassal's corpuscles in prenatal and postnatal nonhuman primates. | calcification of thymic hassal's corpuscles was found in three prematurely delivered fetuses, one each of the species papio papio, macaca mulatta, and saimiri sciureus. the cause of these lesions was not determined. | 1980 | 7464030 |
| characterization of a proteoglycan of high electrophoretic mobility. | proteoglycans from articular cartilage of young baboons (papio papio) were fractionated on an associative density gradient. material from the top of the gradient was shown to contain a proteoglycan of high electrophoretic mobility on large porosity gels. associated and/or contaminating proteins were removed by ion-exchange chromatography on deae-cellulose and subsequent gel filtration on sepharose 4b in the presence of 0.1% sds. the electrophoretically homogeneous proteoglycan (kd 0.43 on sephar ... | 1981 | 7470505 |
| a review of the preclinical pharmacology of tiagabine: a potent and selective anticonvulsant gaba uptake inhibitor. | we review the neurochemical and behavioral profile of the selective gamma-aminobutyric acid (gaba) uptake inhibitor, (r)-n-(4,4-di-(3-methylthien-2-yl)but-3-enyl) nipecotic acid hydrochloride [tiagabine (tgb), previously termed nnc 05-0328, no 05-0328, and no-328], which is currently in phase iii clinical trials for epilepsy. tgb is a potent, and specific gaba uptake inhibitor. tgb lacks significant affinity for other neurotransmitter receptor binding sites and/or uptake sites. in electrophysiol ... | 1995 | 7555976 |
| cingulate kindling in senegalese baboons, papio papio. | kindling of the cingulate cortex in the senegalese baboon papio papio led to a protracted nonconvulsive seizure state characterized by immobile staring with (anterior cingulate, ac) or without (posterior cingulate, pc) widening of eyelids and neck flexion, followed by postictal visual searching behavior. despite early bilateral spread of eeg discharges, ictal and interictal patterns remained persistently asymmetric. secondary generalization was rapid and predictable once contralateral lower faci ... | 1995 | 7588460 |
| reflex epilepsy in the papio-papio baboon, particularly photosensitive epilepsy. | papio-papio baboons may present two types of reflex paroxysmal manifestations: --myoclonia and generalized seizures are induced by intermittent light stimulation in predisposed animals; this photosensitive epilepsy resembles that observed in some human patients; it involves mainly the cerebral cortex during myoclonia which are accompanied by eeg paroxysmal discharges, and the mesencephalic reticular formation during seizures; --myoclonia of a different type, never accompanied by eeg paroxysmal d ... | 1995 | 7642345 |
| the gamma-aminobutyric acid uptake inhibitor, tiagabine, is anticonvulsant in two animal models of reflex epilepsy. | the effects of i.p. administration of the gamma-aminobutyric acid (gaba) uptake inhibitors r(-)n-(4,4-di(3-methylthien-2-yl)-but-3-enyl) nipecotic acid hydrochloride (tiagabine; molecular weight 412.0), (1-(2-(((diphenylmethylene)-amino)oxy)ethyl)-1,2,5,6-tetrahydro-3- pyridinecarboxylic acid hydrochloride (nnc-711; molecular weight 386.9), and (+/-)-nipecotic acid (molecular weight 128.2) are compared with those of carbamazepine (molecular weight 236.3) on sound-induced seizures and locomotor p ... | 1995 | 7737333 |
| control of lipolysis in intra-abdominal fat cells of nonhuman primates: comparison with humans. | the mechanisms that control lipolysis in intra-abdominal fat cells from various primate species, the marmoset (callithrix jacchus), the baboon (papio papio), and the macaque (macaca fascicularis), were compared to those of human intraabdominal fat cells. selective beta 1- or beta 2-adrenoceptor agonists induced lipolysis in all species. selective beta 3-agonists (brl 37344, cl 316243, and sr 58611) acted as partial agonists in marmoset but were inefficient in other primates, including humans. al ... | 1995 | 7775857 |
| beta-adrenergic control of lipolysis in primate white fat cells: a comparative study with nonprimate mammals. | the beta-adrenoceptor subtypes involved in the control of lipolysis in white fat cells of rat, dog, marmoset (callithrix jacchus), baboon (papio papio), macaque (macaca fascicularis), and human were compared. in all species [3h]cgp-12177 binding (up to 3 nm) indicated the existence of a homogeneous population of binding sites in fat cell membranes, and competition studies showed that beta 1- and beta 2-adrenoceptors were present. selective beta 1 or beta 2-adrenoceptor agonists induced lipolysis ... | 1994 | 7914069 |
| globus pallidus and motor initiation: the bilateral effects of unilateral quisqualic acid-induced lesion on reaction times in monkeys. | the results of many experimental studies have shown that the globus pallidus (gp) is involved in the control of motor activities, particularly during motor execution. whether or not the gp is involved in the initiation phase is still a matter of controversy, however. this question was investigated in the present study in papio papio monkeys after gp lesion using a simple reaction time (rt) task, focusing particularly on the initiation phase. the monkeys were trained to perform this task, which c ... | 1994 | 7925805 |
| video-task assessment of stimulus novelty effects on hemispheric lateralization in baboons (papio papio). | in a video matching-to-sample task, we examined the effects of stimulus novelty on hemispheric specialization in 6 baboons (papio papio). after familiarization with a set of 8 composite stimuli, baboons were tested with either familiar stimuli paired in a novel way, novel stimuli composed of familiar elements, or novel stimuli differing in structure from the previous stimuli. analyses focused on visual field differences between initial and later trials in each condition. the findings reflected s ... | 1994 | 8026167 |
| spontaneous isolated lipoma of the choroid plexus in the baboon. | a case of symptomless, solitary lipoma of the choroid plexus is described. the tumour was found in the left lateral ventricle of an adult female baboon (papio papio) in the course of post-mortem examination. routine histological investigation showed that the tumour was composed exclusively of characteristic adipose cells with scarce collagen septa and without other hamartoma-like constituents, such as glial cells, neurons, cartilage or muscle fibres. the tumour mass was lined by a typical single ... | 1994 | 8056876 |
| tissue specificity of the acrosomal protein sp-10: a contraceptive vaccine candidate molecule. | the tissue specificity of the intra-acrosomal protein sp-10 was examined by northern blot and polymerase chain reaction (pcr) analysis. messenger rna from 36 tissues in the female baboon (papio papio) was isolated, separated on agarose gels, transferred to nylon, and probed with either sp-10, beta-actin, or cyclophilin cdna. northern blots, which were processed at both low and high stringency, showed sp-10 to be expressed exclusively in the testis. the mrna from each tissue was also reverse tran ... | 1994 | 8167233 |
| use of stones in a captive group of guinea baboons (papio papio). | 1993 | 8206422 | |
| the cholinergic system-dependent myoclonus of the baboon papio papio is a reticular reflex myoclonus. | neurophysiological studies were performed on four papio papio baboons presenting with nonepileptic myoclonus (a startle response resembling stimulus-sensitive jerk). investigations of the eeg, back-averaged eeg, and somatosensory evoked potentials revealed the absence of cortical correlates preceding the jerks, and exclusion of cerebral cortex involvement. no long-latency reflexes could be recorded in these animals. the jerks were symmetric when evoked by unilateral stimulation in normal baboons ... | 1993 | 8419805 |
| mirror-image matching and mental rotation problem solving by baboons (papio papio): unilateral input enhances performance. | three experiments, using a matching-to-sample procedure, were conducted to examine hemispheric specialization in mirror-image discrimination and mental rotation in baboons (papio papio). in experiment 1, no significant difference was found in discrimination of mirror-image and asymmetric pattern stimuli. in experiment 2, orientation discrimination was assessed within the left (lvf) and right (rvf) visual half-fields. an rvf advantage was found in accuracy for asymmetric patterns, whereas an lvf ... | 1993 | 8440977 |
| cloning and sequencing of baboon and cynomolgus monkey intra-acrosomal protein sp-10: homology with human sp-10 and a mouse sperm antigen (msa-63). | in this study, cdnas encoding the intraacrosomal protein sp-10 were cloned and sequenced from baboon (papio papio) and macaque (macaca fascicularis) testis libraries and the sequence compared to that of human sp-10. two alternatively spliced sp-10 cdnas were obtained from both baboon and macaque testis libraries. the two cdnas in each species contained open reading frames encoding proteins of exactly 285 and 251 amino acids. a 98% homology between baboon and macaque sp-10 was found at the protei ... | 1993 | 8442953 |
| manual and hemispheric specialization in the manipulation of a joystick by baboons (papio papio). | manual performance asymmetries were examined in 8 baboons (papio papio). using a joystick, monkeys had to track and hit with a cursor a randomly moving target on a monitor. the left or right hand was tested first, depending on group assignment, followed by a transfer to the other hand. a transfer effect is reported for the total number of trials to criterion and total number of successful trials. no effect was found for response time. however, for both test and transfer, the group initially test ... | 1993 | 8447954 |
| stable parkinsonian syndrome and uneven loss of striatal dopamine fibres following chronic mptp administration in baboons. | the progressive degeneration of dopamine neurons observed in idiopathic parkinson's disease was mimicked by injecting low doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) to baboons, on a chronic basis. five papio papio baboons were treated on two different regimens (chronic intravenous administration at weekly intervals for 20-21 months or, daily mptp treatment for five days followed five to six months later by chronic weekly injections for 5-21.5 months). all animals were assessed ... | 1993 | 8469305 |
| electrographic studies of the effects of rp 60180, a novel kappa agonist, on the photosensitive baboon papio papio. | 1. the authors describe here the effects of intravenous administration of rp 60180, a novel kappa agonist, on conscious baboons of the species papio papio, which spontaneously present photically induced epileptic responses. 2. animals (n = 2) were chronically implanted with epidural recording electrodes and tested whilst seated in a primate chair. the electrocorticogram (ecog) and electrocardiogram (ecg) were recorded during a control period of at least 30 minutes before the injection of rp 6018 ... | 1995 | 8588066 |
| primary (idiopathic) generalized epilepsy and underlying mechanisms. | primary generalized epilepsy (pge) has been more hotly debated over the past decades than other forms of epileptic seizure disorder. the sudden synchronous appearance of bilateral spikes and spike-waves (mainly with myoclonus resp. absence) used to perplex the earliest generation of electroencephalographers, and the enigmatic genesis of these discharges (and seizures) has not ceased to fascinate the investigators of this phenomenon. a "centrencephalic" concept with paroxysmal discharges arising ... | 1996 | 8719497 |
| gaba and epilepsy in the photosensitive baboon papio papio. | 1996 | 8895974 | |
| [somatosensory evoked potentials: morphology and interareal s1-m1 relationships in the baboon (papio papio)]. | primary somatosensory potentials (seps) were elicited by electrical stimulation of the medial sciatic (proprioceptive) or sural (cutaneous) nerves. they were detected by contacts on si and mi dura on both cortical sides against a cephalic reference. seps were averaged (n = 20). primary si sep consisted of positive, then negative, pi6/n30 waves. n30 was absent from mi records. local electrocoagulation of the si cortex on one side has entailed some reduction, but not suppression of together the ho ... | 1996 | 9102564 |
| processing of global and local visual information and hemispheric specialization in humans (homo sapiens) and baboons (papio papio). | global precedence was examined in 8 baboons and 14 humans using compound stimuli presented in the left visual hemifield (lvf) or the right visual hemifield (rvf). humans showed a global advantage and global-to-local interference. baboons showed a local advantage and no interference. for humans and baboons, a lvf advantage appeared for global matching and an unsignificant rvf advantage appeared for local matching. the local advantage in baboons still emerged when the memory load of the task was r ... | 1997 | 9104003 |
| sequence and characterization of the sperm protein sp17 from the baboon. | in this study, cdnas encoding the sperm protein sp17 from the baboon (papio papio) have been cloned and sequenced. three clones, differing in the lengths of their 3' untranslated regions, were identified, which were encoded by mrna transcripts of 0.8-1.35 kb. the open reading frame encodes 163 amino acids with a predicted molecular mass of 18.8 kda. the baboon sp17 protein sequence is 97% identical to human sp17 but differs significantly by the addition of 12 amino acids at the c-terminal, provi ... | 1997 | 9110316 |
| localization of fcgr1 encoding fcgamma receptor class i in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1. | the human high-affinity receptor for immunoglobulin g, fcgammari (fcgr1), is encoded by a family of three genes that share over 95% sequence homology. curiously, the three genes in this recently duplicated gene family flank the centromere of human chromosome 1, with fcgr1b located at 1p12 and both fcgr1a and fcgr1c located at 1q21. we have previously speculated that a pericentric inversion could account for the separation of the genes in the fcgr1 family and explain their current chromosomal loc ... | 1998 | 9763663 |
| comparative assessment of distance processing and hemispheric specialization in humans and baboons (papio papio). | this comparative study explored the ability to process distance and its lateralization in humans and baboons. using a conditional matching-to-sample procedure in a divided-field format, subjects had to decide whether or not the distance between a line and a dot belonged to a short- or a long-distance category. experiments 1, 2, and 4 demonstrated the ability of baboons to process and categorize distances. moreover, humans showed better distance processing for right visual field/left hemisphere p ... | 1998 | 9853095 |
| reproductive parameters and paracallosal skin color changes in captive female guinea baboons, papio papio. | reproductive data are presented for female papio papio housed in the zoological park of paris and are compared with previously published data from free-ranging populations of other baboon species. the results indicate similar intermenstrual intervals and durations of sexual swelling. sexual swelling and pregnancy are accelerated in captivity, while postpartum amenorrhea and interbirth interval are reduced. interbirth intervals in p. papio were short, approximately 13 months in the case of viable ... | 1999 | 9888723 |
| synthesis of a fluorine-18 labeled derivative of epibatidine for in vivo nicotinic acetylcholine receptor pet imaging. | epibatidine (exo-2-(2'-chloro-5'-pyridyl)-7-azabicyclo[2.2.1]heptane), a natural compound isolated from the skin of the ecuadorian poison frog epipedobates tricolor, is the most potent nicotinic acetylcholine receptor (nachr) agonist reported to date. in order to visualize and quantify in vivo these receptors in human brain using positron emission tomography (pet), [18f]norchlorofluoroepibatidine (exo-2-(2'-[18f]fluoro-5'-pyridyl)-7-azabicyclo[2.2.1]heptane), a fluorine-18 (t(1/2): 110 min) radi ... | 1999 | 10220033 |
| intronic sequence motifs of hla-dqb1 are shared between humans, apes and old world monkeys, but a retroviral ltr element (dqltr3) is human specific. | long terminal repeats (ltrs) of the human endogenous retrovirus k (herv-k) family have been found at several sites within the human genome, of which one is located in the vicinity of hla-dqb1. since this dqltr3 is only present on some haplotypes, we performed a linkage analysis in 130 caucasian families. in order to date the integration event we also investigated the presence of this dqltr3 in apes and old world monkeys. additionally, we sequenced the adjacent region of dqltr3-positive and -nega ... | 1999 | 10395105 |