Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| common infections and the risk of stroke. | the occurrence of stroke in populations is incompletely explained by traditional vascular risk factors. data from several case-control studies and one large study using case series methodology indicate that recent infection is a temporarily acting, independent trigger factor for ischemic stroke. both bacterial and viral infections, particularly respiratory tract infections, contribute to this association. a causal role for infection in stroke is supported by a graded temporal relationship betwee ... | 2010 | 21060340 |
| chlamydia pneumoniae infection-related hemophagocytic lymphohistiocytosis and acute encephalitis and poliomyelitis-like flaccid paralysis. | a 3-year-old male presented with chlamydia pneumoniae infection-related hemophagocytic lymphohistiocytosis (hlh). the patient developed an episode of hlh with severe skin eruption following c. pneumoniae pneumonia. symptoms responded to steroid/cyclosporine a therapy, but the patient slowly lost consciousness and developed systemic flaccid paralysis. he was diagnosed with encephalitis/myelitis by brain and spinal mri. neurological symptoms and signs gradually resolved. we thought that the immune ... | 2010 | 21058284 |
| chlamydophila pneumoniae induces production of the defensin-like mig/cxcl9, which has in vitro antichlamydial activity. | cxc chemokines that lack the elr motif, including the monokine induced by ifn-γ (mig/cxcl9), the ifn-induced protein of 10 kda (ip-10/cxcl10), and the ifn-inducible t-cell α-chemoattractant (i-tac/cxcl11), have been shown to mediate the generation of type 1 immune responses and to possess defensin-like bactericidal effects. this study revealed that the infection of mice with chlamydophila pneumoniae via the intranasal route resulted in the local expression of mig/cxcl9, ip-10/cxcl10, and i-tac/c ... | 2010 | 21056004 |
| cleavage of the nf-{kappa}b family protein p65/rela by the chlamydial protease-like activity factor (cpaf) impairs proinflammatory signaling in cells infected with chlamydiae. | chlamydiae are obligate intracellular bacteria that frequently cause human disease. chlamydiae replicate in a membranous vacuole in the cytoplasm termed inclusion but have the ability to transport proteins into the host cell cytosol. chlamydial replication is associated with numerous changes of host cell functions, and these changes are often linked to proteolytic events. it has been shown earlier that the member of the nf-κb family of inflammation-associated transcription factors, p65/rela, is ... | 2010 | 21041296 |
| malnutrition, infection and arteriovenous fistula failure: is there a link? | the histology of neointimal hyperplasia, the primary cause of arteriovenous fistula (avf) stenosis, resembles the histology of atherosclerosis. we evaluated classic atherogenic risk factors such as hypertension, smoking, diabetes, cholesterol, and evaluated the role of expanded risk factors such as: cytomegalovirus (cmv), helicobacter pylori (h. pylori), chlamydia pneumoniae (c. pneumoniae), infection, and malnutrition, as possible causes of avf failure in hemodialysis (hd) patients. | 2011 | 21038306 |
| effects of atypical infections with mycoplasma and chlamydia on asthma. | mycoplasma pneumoniae and chlamydophila pneumoniae are atypical bacteria that are frequently found in patients with asthma. a definitive diagnosis of infection is often difficult to obtain because of limitations with sampling and detection. numerous animal studies have outlined mechanisms by which these infections may promote allergic lung inflammation and airway remodeling. in addition, there is mounting evidence from human studies suggesting that atypical bacterial infections contribute to ast ... | 2010 | 21029940 |
| bacterial infections and pediatric asthma. | streptococcus pneumoniae, haemophilus influenzae and moraxella catarrhalis seem to have no role in asthma in children. mycoplasma pneumoniae and chlamydophila pneumoniae can induce wheezing and cause asthma exacerbations in children, and chronic chlamydophila infections may even participate in asthma pathogenesis. however, studies have failed to show any benefits from antibiotics for incipient or stable pediatric asthma, as well as for asthma exacerbations in children. exposure to antibiotics in ... | 2010 | 21029939 |
| a graph-based algorithm for mining multi-level patterns in genomic data. | comparative genomics is concerned with the study of genome structure and function of different species. it can provide useful information for the derivation of evolutionary and functional relationships between genomes. previous work on genome comparison focuses mainly on comparing the entire genomes for visualization without further analysis. as many interesting patterns may exist between genomes and may lead to the discovering of functional gene segments (groups of genes), we propose an algorit ... | 2010 | 20981888 |
| nursing home-acquired pneumonia: a review of risk factors and therapeutic approaches. | to review the risk factors, etiologic profile, treatment approaches, and guidelines for the management of nursing home-acquired pneumonia (nhap). | 2010 | 20973617 |
| [epidemiology and morbidity of mycoplasma as causative agent for community-acquired pneumonia in hospitalized children in a community hospital in vienna.] | background: epidemiology and morbidity of mycoplasma-associated pneumonia in youths and children in vienna are not known. the first objective was to elucidate the incidence and the second was to evaluate a standard antibiotic regimen with addition of a macrolid in children over 5 years. methods: hospitalized patients were evaluated prospectively during 3 winter seasons. in a clinical routine setting microbiologic tests were performed, nasal secretions were tested for viruses, chlamydia pneumonia ... | 2010 | 20963506 |
| nasopharyngeal bacterial colonization during the first wheezing episode is associated with longer duration of hospitalization and higher risk of relapse in young children. | the purpose of this study was to examine the association between bacterial colonization/infection and respiratory outcomes in children younger than 3 years old who were hospitalized for their first wheezing episode. this was an observational study. the primary outcome was hospitalization time and the secondary outcomes included relapses within 2 months and time to recurrent wheezing (i.e. three physician confirmed wheezing episodes) within 12 months. bacterial antibody assays for streptococcus p ... | 2010 | 20938703 |
| il-17a is proatherogenic in high-fat diet-induced and chlamydia pneumoniae infection-accelerated atherosclerosis in mice. | the role of il-17 in atherogenesis remains controversial. we previously reported that the tlr/myd88 signaling pathway plays an important role in high-fat diet as well as chlamydophila pneumoniae infection-mediated acceleration of atherosclerosis in apolipoprotein e-deficient mice. in this study, we investigated the role of the il-17a in high-fat diet (hfd)- and c. pneumoniae-induced acceleration of atherosclerosis. the aortic sinus plaque and aortic lesion size and lipid composition as well as m ... | 2010 | 20935201 |
| design and synthesis of 2-arylbenzimidazoles and evaluation of their inhibitory effect against chlamydia pneumoniae. | chlamydia pneumoniae is an intracellular bacterium that responds poorly to antibiotic treatment. insufficient antibiotic usage leads to chronic infection, which is linked to disease processes of asthma, atherosclerosis, and alzheimer's disease. the chlamydia research lacks genetic tools exploited by other antimicrobial research, and thus other approaches to drug discovery must be applied. a set of 2-arylbenzimidazoles was designed based on our earlier findings, and 33 derivatives were synthesize ... | 2010 | 20932010 |
| impact of seropositivity to chlamydia pneumoniae and anti-hhsp60 on cardiovascular events in hemodialysis patients. | autoimmunity to heat shock protein 60 (hsp60) has been related to atherosclerosis. chlamydia pneumoniae (cp), the most studied infectious agent implicated in promoting atherosclerosis, produces a form of hsp60, which can induce an autoimmune response, due to high antigenic homology with human hsp60 (hhsp60). in this study, we evaluated the correlations among anti-hhsp60 antibodies, cp infection, and cardiovascular disease (cvd) in a high-risk population, such as patients undergoing hemodialysis ... | 2010 | 20922511 |
| a trial of clarithromycin for the treatment of suboptimally controlled asthma. | pcr studies have demonstrated evidence of mycoplasma pneumoniae and chlamydophila pneumoniae in the lower airways of patients with asthma. | 2010 | 20920764 |
| human parainfluenza virus type 3 (hpiv 3) community-acquired pneumonia (cap) mimicking pertussis in an adult: the diagnostic importance of hoarseness and monocytosis. | background: there are relatively few causes of acute community-acquired pneumonias (caps) in adults associated with prolonged cough. in adults the most common acute caps with a prominent and persistent nonproductive cough are due to mycoplasma pneumoniae, chlamydophilia (chlamydia) pneumoniae, or bordetella pertussis (pertussis). pertussis is an underrecognized and underappreciated cause of cap in adults. different from classic pertussis in children, pertussis in adults presents with prolonged d ... | 2010 | 20888644 |
| [development of pulmonary chlamydia infection in inbred mice lines differentiated by genetically determinated sensitivity to tuberculosis infection]. | mice of i/st strain develop severe lung inflammation and die shortly following infection with virulent mycobacteria. the susceptibility does not depend on the nramp1 gene, as i/st mice carry its resistant allele, but is controlled by little interacting qtl mapped to chromosomes 3, 9, 17. to find out whether the tuberculosis-susceptible i/st mice are susceptible to other intracellular bacteria taxonomically distant pathogen of chlamydia pneumoniae was studied. comparison of i/st and tb-resistant ... | 2010 | 20882771 |
| [the clinical and morphological features of chlamydia pneumoniae-induced chorioretinitis in an experiment]. | the clinical and pathomorphological features of vitreous retinochorioidal complex lesion with the pathogen chlamydia pneumoniae were studied. three rabbits (6 eyes) were infected with ch. pneumoniae strain twar by instillation, subconjunctivally and 2 eyes were infected by intravitreally. contamination was controlled by direct immunofluorescence and cultivation (conjunctival scrapes, venous blood). a postmortem study was conducted 128 days later, by employing an immunohistochemical analysis. on ... | 2010 | 20873153 |
| chlamydia pneumoniae disturbs cholesterol homeostasis in human thp-1 macrophages via jnk-pparγ dependent signal transduction pathways. | chlamydia pneumoniae (c. pneumoniae) induces macrophage-derived foam cell formation, a hallmark of early atherosclerosis, in the presence of low density lipoprotein (ldl). however, its mechanisms have yet to be elucidated. in this study we examined the effects of live, heat-killed and uv-inactivated c. pneumoniae on cholesterol metabolism in thp-1-derived macrophages and the role of c-jun nh(2) terminal kinase (jnk), which may participate in the c. pneumoniae-induced disruption of intracellular ... | 2010 | 20870032 |
| immunohistological detection of chlamydia pneumoniae in the alzheimer's disease brain. | sporadic late-onset alzheimer's disease (ad) appears to evolve from an interplay between genetic and environmental factors. one environmental factor that continues to be of great interest is that of chlamydia pneumoniae infection and its association with late-onset disease. detection of this organism in clinical and autopsy samples has proved challenging using a variety of molecular and histological techniques. our current investigation utilized immunohistochemistry with a battery of commerciall ... | 2010 | 20863379 |
| antibodies to various mycoplasmas in patients with coronary heart disease. | clinical and epidemiologic features of coronary heart disease may not be explained solely by established risk factors. the role of infectious pathogens in the development and rupture of atherosclerotic plaques remains elusive but an association between chlamydia pneumoniae, mycoplasma pneumoniae and chd has been reported previously. | 2010 | 20862818 |
| coinfection with ebv/cmv and other respiratory agents in children with suspected infectious mononucleosis. | numerous studies have shown that epstein-barr virus (ebv) and cytomegalovirus (cmv) can infect immunocompetent patients simultaneously with other agents. nonetheless, multiple infections with other agents in ebv/cmv-infected children have received little attention. we conducted a retrospective study of children with suspected infectious mononucleosis. peripheral blood samples were analyzed by indirect immunofluorescence to detect ebv, cmv and other respiratory agents including respiratory syncyt ... | 2010 | 20858235 |
| acute and chronic chlamydia pneumoniae infection in pregnancy complicated with preeclampsia. | to investigate whether chlamydia pneumoniae (cp) infection is more common in women whose current pregnancy is complicated with preeclampsia (pe) as compared to pregnant women without pe. | 2011 | 20849251 |
| chlamydia pneumoniae infection as a risk factor for accelerated atherosclerosis in hemodialysis patients. | atherosclerotic cardiovascular disease is the main cause of morbidity and mortality for end-stage renal disease patients undergoing chronic haemodialysis (hd). several studies in recent years have identified chlamydia pneumoniae, a respiratory pathogen, as risk factor for cardiovascular diseases in the general population. the aim of our study is to evaluate chlamydial load, in peripheral blood mononuclear cells (pbmc) of hd patients. furthermore, the correlation between dna chlamydial load and m ... | 2010 | 20846485 |
| ectopic lymphoid tissue formation in the lungs of mice infected with chlamydia pneumoniae is associated with epithelial macrophage inflammatory protein-2/cxcl2 expression. | infection with chlamydia pneumoniae (cp) accounts for around 10% of community acquired bacterial pneumonia and has been associated with other chronic inflammatory conditions. we describe a c57/bl6 murine model of cp lung infection characterized by a dose-dependent, resolving neutrophilia followed by lymphocytic infiltration of the lungs. by 21 days post-infection, mice exhibit a t helper type 1 (th1) polarized serum antibody response with local mucosal antibody secretion and organization of ecto ... | 2010 | 20840653 |
| role of myd88 and toll-like receptors 2 and 4 in the sensing of parachlamydia acanthamoebae. | parachlamydia acanthamoebae is a chlamydia-related organism whose pathogenic role in pneumonia is supported by serological and molecular clinical studies and an experimental mouse model of lung infection. toll-like receptors (tlrs) play a seminal role in sensing microbial products and initiating innate immune responses. the aim of this study was to investigate the roles of myd88, tlr2, and tlr4 in the interaction of parachlamydia with macrophages. here, we showed that parachlamydia entered bone- ... | 2010 | 20837714 |
| chlamydia pneumoniae infection in preeclampsia. | the maternal syndrome of preeclampsia results from systemic endothelial activation by a number of factors that primarily derive from the intervillous space, so-called intervillous soup. co-precipitants, such as innate immune activators, may lower the threshold to develop the maternal syndrome in preeclampsia. we examined whether, like atherosclerosis, preeclampsia is associated with infection with chlamydia pneumoniae (c. pneumoniae). | 2010 | 20818953 |
| the role of infections in the pathogenesis and course of multiple sclerosis. | interplay between susceptibility genes and environmental factors is considered important player in the genesis of multiple sclerosis (ms). among environmental factors, a role for an infectious pathogen has long been considered central to the disease process. this opinion has support both from epidemiological data and the findings of immunological abnormalities in spinal fluid that reflect an immune response to an as yet undetermined antigen, possibly a pathogen, in the cerebrospinal fluid. our r ... | 2010 | 20814489 |
| respiratory syncytial virus infection and risk of acute myocardial infarction. | increasing evidences have shown that pathogens may promote atherosclerosis and trigger acute myocardial infarction (ami). there is no report on the association between respiratory syncytial virus (rsv) infection and ami. the case-control study was used to assess the association of previous rsv infection and acute myocardial infarction. | 2010 | 20811272 |
| persistent chlamydia pneumoniae serology is related to decline in lung function in women but not in men. effect of persistent chlamydia pneumoniae infection on lung function. | chlamydia pneumoniae (c pn) infection causes an acute inflammation in the respiratory system that may become persistent, but little is known about the long-term respiratory effects of c pn infections. aim: to estimate the long term respiratory effects of c pn with change in forced expiratory volume in one second (fev1) and forced vital capacity (fvc) as a main outcome variable. | 2010 | 20738859 |
| serological diagnosis of chlamydia pneumoniae infection: limitations and perspectives. | chlamydia pneumoniae is an obligate intracellular human pathogen responsible for a wide range of acute and chronic human diseases, including pneumonia and other respiratory diseases. serological methods for the diagnosis of c. pneumoniae infection vary widely, and several authors have reported significant inter- and intra-laboratory variability in diagnostic methods and criteria. over the past 10 years, numerous studies have focused on the identification of specific antigens for application in s ... | 2010 | 20724512 |
| is chlamydia pneumoniae seropositivity associated with atherothrombotic cerebrovascular infarction? | several studies suggested that chlamydia pneumoniae (cp) infection may be a risk factor for cerebrovascular disease. since these studies have reported controversial results, we performed this study to identify whether cp-immunoglobulin was associated with atherothrombotic cerebrovascular infarction (aci) in iranian patients. | 2009 | 20701868 |
| [the implication of chlamydia pneumoniae in damage to human aortic endotheliocytes in atherosclerosis]. | a cytological technique was used to study the impressions of the aortic intima of dead patients. endothelial cell chlamydia pneumoniae (cp) was detected in 26 (56.5%) of 46 dead patients; the bacterium was found in the unaffected intact intimal areas in 9 (19.6%) cases. three morphological forms of cp--inclusions, spots, and aggregates were described. the whole life cycle of cp and the specific features of disintegration of the host cell--the endothelium were observed. cp leads to extensive infe ... | 2010 | 20698311 |
| [one year observation of natural course of aortic valve stenosis in patients with normal and abnormal lipoprotein (a) plasma level]. | the observation of natural course of aortic valvae stenosis (avs) in patients with high lipoprotein (a) [lp(a)]. | 2010 | 20687376 |
| identification of phylogenetic position in the chlamydiaceae family for chlamydia strains released from monkeys and humans with chlamydial pathology. | based on the results of the comparative analysis concerning relatedness and evolutional difference of the 16s-23s nucleotide sequences of the middle ribosomal cluster and 23s rrna i domain, and based on identification of phylogenetic position for chlamydophila pneumoniae and chlamydia trichomatis strains released from monkeys, relatedness of the above stated isolates with similar strains released from humans and with strains having nucleotide sequences presented in the genbank electronic databas ... | 2010 | 20671971 |
| ultrastructural analysis of chlamydia pneumoniae in the alzheimer's brain. | we recently reported identification of the bacterium chlamydia pneumoniae in affected brain regions of patients with alzheimer's disease (ad) (balin et al., 1998). in this report, we extend those initial observations to demonstrate that, in addition to the frequently described, standard morphological forms of the organism, pleiomorphic forms are also present in the ad brain. all ad and control brain tissues examined were verified to be pcr-positive and negative, respectively, for the organism. d ... | 1999 | 20671799 |
| [role of chlamydia pneumoniae and mycoplasma pneumoniae infections in the course of asthma]. | respiratory infections are one of the major causes of asthma exacerbations. among numerous pathogens that may lead to exacerbations, particular attention should be paid to atypical bacteria: chlamydia pneumoniae and mycoplasma pneumoniae. despite significant frequency, infections caused by these species are underestimated due to untypical clinical course and lack of easily accessible diagnostic tests. although acute infection can be easily linked with deterioration of asthma control, the role of ... | 2010 | 20665449 |
| stratification for confounding--part 1: the mantel-haenszel formula. | stratification allows to control for confounding by creating two or more categories or subgroups in which the confounding variable either does not vary or does not vary very much. the mantel-haenszel formula is applied in cohort and in case-control studies to calculate an overall, unconfounded, effect estimate of a given exposure for a specific outcome by combining stratum-specific relative risks (rr) or odds ratios (or). stratum-specific rrs or ors are calculated within each stratum of the conf ... | 2010 | 20664286 |
| sequencing of chlamydia pneumoniae in coronary artery disease patients attending tertiary hospital in india. | 2010 | 20656133 | |
| possibilities for therapeutic interventions in disrupting chlamydophila pneumoniae involvement in atherosclerosis. | strong sero-epidemiologic, pathologic, and experimental evidence suggests that chlamydophila pneumoniae (cpn) infection may play a causative role in the development of atherosclerosis. cpn is an obligate intracellular gram-negative bacterium that is responsible for 10% of cases of community-acquired pneumonia. in addition to its presence in the respiratory tract, live cpn has been found within atherosclerotic plaques. experimental findings have established cpn's ability to infect vascular cells ... | 2010 | 20653790 |
| inducible expression of human {beta}-defensin 2 by chlamydophila pneumoniae in brain capillary endothelial cells. | defensins are an important family of natural antimicrobial peptides. chlamydophila pneumoniae, a common cause of acute respiratory infection, has a tendency to cause persistent inflammatory diseases such as atherosclerosis, which may lead to cardiovascular disease or stroke. as endothelial cells are related to the physiopathology of stroke, the effects of in vitro c. pneumoniae infection on the expression of human beta-defensin 2 (hbd-2) in brain capillary endothelial cells (bb19) was investigat ... | 2010 | 20647256 |
| divergent modulation of chlamydia pneumoniae infection cycle in human monocytic and endothelial cells by iron, tryptophan availability and interferon gamma. | chlamydia pneumoniae is an obligatory intracellular bacterium causing chronic inflammatory diseases in humans. we studied the role of the nutritive factors, iron and tryptophan, towards the course of infection and immune response pathways in c. pneumoniae infected endothelial cells and monocytes. human endothelial (ea.hy923) and monocytic cells (thp-1) were infected with c. pneumoniae, supplemented with iron or 1-methyltryptophan (1-mt), an inhibitor of the tryptophan degrading enzyme indoleamin ... | 2010 | 20646782 |
| comparison of koala lpcoln and human strains of chlamydia pneumoniae highlights extended genetic diversity in the species. | chlamydia pneumoniae is a widespread pathogen causing upper and lower respiratory tract infections in addition to a range of other diseases in humans and animals. previous whole genome analyses have focused on four essentially clonal (> 99% identity) c. pneumoniae human genomes (ar39, cwl029, j138 and tw183), providing relatively little insight into strain diversity and evolution of this species. | 2010 | 20646324 |
| the effect of chlamydophila pneumoniae major outer membrane protein (momp) on macrophage and t cell-mediated immune responses. | the major outer membrane protein (momp) belongs to the membrane complex of cysteine-rich proteins of chlamydophila pneumoniae. although momp can elicit strong immune responses it fails to confer long-term protection against infection in animal models. this effect has been attributed, at least in part, to an inadequate induction of protective th1-mediated immune responses. in an effort to understand the cellular mechanisms associated to the immunomodulatory properties of momp we studied the effec ... | 2011 | 20637522 |
| apolipoprotein e-deficient mice develop an anti-chlamydophila pneumoniae t helper 2 response and resist vascular infection. | hypercholesterolemia could inhibit the immune response against various pathogens. no information is available about its impact on the immune response toward chlamydophila pneumoniae. | 2010 | 20632890 |
| the potential for the noninvasive delivery of polymeric nanocarriers using propellant-based inhalers in the treatment of chlamydial respiratory infections. | a novel strategy for pulmonary delivery of polymeric nanocarriers (ncs) pressurized-metered dose inhalers (pmdis) is reported in this work. core-shell particles consisting of a water soluble, hydrofluoroalkane(hfa)-philic biodegradable copolymer of chitosan and poly(lactic acid), and a core of poly(d,l-lactide-co-glycolide) (plga) ncs were prepared by a modified emulsification-diffusion methodology. dispersions of the core-shell particles in hfa propellant revealed enhanced physical stability co ... | 2010 | 20615546 |
| inhibitory effect of the natural product betulin and its derivatives against the intracellular bacterium chlamydia pneumoniae. | chlamydia pneumoniae is a universal pathogen that has been indicated to play a part in the development of asthma, atherosclerosis and lung cancer. the complete eradication of this intracellular bacterium is in practice impossible with the antibiotics that are currently in use and studies on new antichlamydial compounds is challenging because chlamydia research lacks the tools required for the genetic modification of this bacterium. betulin is a natural lupane-class triterpene derived from plants ... | 2010 | 20615390 |
| limited utility of culture for mycoplasma pneumoniae and chlamydophila pneumoniae for diagnosis of respiratory tract infections. | we assessed the utility of culture for mycoplasma pneumoniae and chlamydophila pneumoniae to diagnose respiratory tract infections. compared to pcr and igm serology, culture was less sensitive and had extremely low yield. culture is not recommended for these pathogens, and this method should be eliminated from routine practice. | 2010 | 20610673 |
| the association of infectious agents and schizophrenia. | the influence of infectious agents on the pathogenesis of psychiatric disorders has been discussed for decades. pre- and postnatal infections are risk factors for schizophrenia. this may be explained by chronic infections or an altered immune status. however most of the studies have only focused on one single pathogen and not on the impact of different infectious agents. we investigated the association between schizophrenia and various neurotophic infectious agents. | 2010 | 20602604 |
| isolation of chlamydia pneumoniae from serum samples of the patients with acute coronary syndrome. | limited body of evidence suggests that lipopolysaccharide of c. pneumoniae as well as c. pneumoniae-specific immune complexes can be detected and isolated from human serum. the aim of this study was to investigate the presence of viable elementary bodies of c.pneumoniae in serum samples of patients with acute coronary syndrome and healthy volunteers. | 2010 | 20596362 |
| exploiting antigenic diversity for vaccine design: the chlamydia artj paradigm. | we present an interdisciplinary approach that, by incorporating a range of experimental and computational techniques, allows the identification and characterization of functional/immunogenic domains. this approach has been applied to artj, an arginine-binding protein whose orthologs in chlamydiae trachomatis (ct artj) and pneumoniae (cpn artj) are shown to have different immunogenic properties despite a high sequence similarity (60% identity). we have solved the crystallographic structures of ct ... | 2010 | 20592031 |
| primary chlamydial infection correlates with high level of serum interleukin 12 (il-12). | according to the existing data, cytokines actively participate in the pathogenesis of chlamydia infection. however, the role of il-12 in chlamydiosis development has not been studied yet. the aim of our research is to define the role of il-12 in the pathogenesis of the disease. the levels of il-12, il-4 and ifn-gamma were determined in 27 healthy and 56 chlamydia infected individuals by using sandwich elisa in vitro. enzyme-linked immunosorbent assay, direct and indirect immunoflourescence were ... | 2010 | 20587833 |
| induced expression of lectin-like oxidized ldl receptor-1 in vascular smooth muscle cells following chlamydia pneumoniae infection and its down-regulation by fluvastatin. | microorganisms such as chlamydia pneumoniae have been shown to infect vascular cells and are believed to contribute to vascular inflammation and atherosclerotic plaque development. plasma levels of oxidized low density lipoprotein (oxldl) have received considerable attention as potential predictors of prognosis in atherosclerotic diseases. lectin-like oxidized ldl receptor-1 (lox-1) is one of the major receptors for oxidized ldl. it was investigated whether c. pneumoniae infection can stimulate ... | 2010 | 20587387 |
| fastidious intracellular bacteria as causal agents of community-acquired pneumonia. | intracellular bacteria are common causes of community-acquired pneumonia that grow poorly or not at all on standard culture media and do not respond to beta-lactam antibiotic therapy. apart from well-established agents of pneumonia such as legionella pneumophila, mycoplasma pneumoniae, chlamydia pneumoniae, chlamydia psittaci and coxiella burnetii, some new emerging pathogens have recently been recognized, mainly parachlamydia acanthamoebae and simkania negevensis, two chlamydia-related bacteria ... | 2010 | 20586563 |
| systemic inflammation caused by chronic periodontite in patients victims of acute ischemic heart attack. | infectious and inflammatory processes mediated by bacteria in distant sites have been described as a risk factor for acute ischemic heart disease (aihd). | 2010 | 20563468 |
| association of carotid plaque lp-pla(2) with macrophages and chlamydia pneumoniae infection among patients at risk for stroke. | we previously showed that the burden of chlamydia pneumoniae in carotid plaques was significantly associated with plaque interleukin (il)-6, and serum il-6 and c-reactive protein (crp), suggesting that infected plaques contribute to systemic inflammatory markers in patients with stroke risk. since lipoprotein-associated phospholipase a2 (lp-pla(2)) mediates inflammation in atherosclerosis, we hypothesized that serum lp-pla(2) mass and activity levels and plaque lp-pla(2) may be influenced by pla ... | 2010 | 20543948 |
| [acute renal failure following chlamydia pneumoniae pneumonia in a child]. | acute renal failure (arf) following chlamydia pneumoniae pneumonia is rarely reported in adults. we present an observation in a 10-year-old child, who had c. pneumoniae pneumonia treated with roxithromycin for a period of 10 days, without any other nephrotoxic drug, in particular nonsteroidal anti-inflammatory drugs. at the end of antibiotic treatment, he presented with asthenia, polyuria, polydipsia, increased plasma creatinine, metabolic acidosis, hypokalemia, and markers of tubular damage. th ... | 2010 | 20541377 |
| rapamycin can inhibit the development of chlamydia pneumoniae, which might partly contribute to the prevention of in-stent restenosis. | rapamycin, an immunosuppressive and antiproliferative drug, is used to prevent neointima formation to reduce the risk of in-stent restenosis with rapamycin eluting-stents. chronic infection of chlamydia pneumoniae has been associated with cardiovascular diseases, and could play an important role in the mechanism of restenosis. we examined the effect of rapamycin on the growth of c. pneumoniae in cell cultures. | 2010 | 20532971 |
| chlamydia pneumoniae and metabolic syndrome. | 2010 | 20531037 | |
| atypical bacteria and macrolides in asthma. | : chlamydophila pneumoniae and mycoplasma pneumoniae are common pathogens causing acute illness in both the upper and lower airways. several observations are supportive of a possible causative role of these pathogens in asthma; however, more evidence is required before this becomes meaningful in clinical practice. atypical bacteria can enhance airway hyperresponsiveness and inflammation, both of which have been associated with exacerbations in patients with preexisting asthma. it is less clear w ... | 2008 | 20525132 |
| clarithromycin use and risk of death in patients with ischemic heart disease. | to examine whether treatment with clarithromycin was associated with an increased risk of death in patients with preexisting ischemic heart disease (ihd). | 2010 | 20523043 |
| fdg/pet uptake in asymptomatic multilobar chlamydia pneumoniae pneumonia. | fdg-pet is a diagnostic imaging procedure effective in staging primary and recurrent cancer. false-positive uptake already has been described in both inflammatory and infectious respiratory diseases, although no reports associate chlamydia pneumoniae infection to fdg uptake. | 2010 | 20512095 |
| viruses and atypical bacteria associated with asthma exacerbations in hospitalized children. | objectives and working hypothesis: to evaluate the prevalence of respiratory viruses mycoplasma pneumoniae and chlamydophila pneumoniae and gain insight into their seasonal circulation pattern in children with acute asthma exacerbations in a temperate southern hemisphere region. | 2010 | 20503289 |
| chlamydia pneumoniae is genetically diverse in animals and appears to have crossed the host barrier to humans on (at least) two occasions. | chlamydia pneumoniae is a common human and animal pathogen associated with a wide range of diseases. since the first isolation of c. pneumoniae twar in 1965, all human isolates have been essentially clonal, providing little evolutionary insight. to address this gap, we investigated the genetic diversity of 30 isolates from diverse geographical locations, from both human and animal origin (amphibian, reptilian, equine and marsupial). based on the level of variation that we observed at 23 discreet ... | 2010 | 20502684 |
| chlamydia pneumoniae infection and risk for lung cancer. | we evaluated the relationship of chlamydia pneumoniae infection with prospective lung cancer risk using traditional serologic markers [microimmunoflourescence (mif) igg and iga antibodies] and chlamydia heat shock protein-60 (chsp-60) antibodies, a marker for chronic chlamydial infection. | 2010 | 20501758 |
| development of triplex sybr green real-time pcr for detecting mycoplasma pneumoniae, chlamydophila pneumoniae, and legionella spp. without extraction of dna. | although mycoplasma pneumoniae, chlamydophila pneumoniae, and legionella spp. are prevalent causes of community-acquired pneumonia, rapid and sensitive diagnosis is difficult. real-time pcr provides rapid and sensitive diagnosis, however, dna extraction is still required, which is time-consuming, costly and includes a risk of contamination. therefore, we aimed to develop triplex real-time pcr without dna extraction. ampdirect(r) plus which inhibits pcr inhibitors was used as the pcr buffer. melt ... | 2010 | 20495268 |
| a multicenter pilot external quality assessment programme to assess the quality of molecular detection of chlamydophila pneumoniae and mycoplasma pneumoniae. | an external quality assessment (eqa) panel consisting of a total of 13 samples in broncho alveolar lavage (bal) or transport medium was prepared to assess the proficiency of laboratories in the correct detection of chlamydophila pneumoniae and mycoplasma pneumoniae by nucleic acid amplification techniques (naats) (6 samples containing various concentrations (4.9-490 inclusion forming units (ifu)/ml) of c. pneumoniae, 5 samples containing various concentrations (20-5000 color-changing units (ccu) ... | 2010 | 20493214 |
| increased inflammation and impaired resistance to chlamydophila pneumoniae infection in dusp1(-/-) mice: critical role of il-6. | the mapk phosphatase dusp1 is an essential negative regulator of tlr-triggered innate immune activation. here, we have investigated the impact of dusp1 on inflammatory and antimicrobial host responses to the intracellular pathogen chlamydophila pneumoniae. following nasal infection, dusp1-deficient mice mounted an enhanced pulmonary cytokine (il-1beta, il-6) and chemokine response (ccl3, ccl4, cxcl1, cxcl2), leading to increased leukocyte infiltration. of interest, the increased inflammatory res ... | 2010 | 20483921 |
| in vitro antibacterial activities of s-013420, a novel bicyclolide, against respiratory tract pathogens. | the in vitro activity of s-013420, a novel bicyclolide, was investigated. | 2010 | 20472695 |
| chlamydia pneumoniae infection suppresses staphylococcus enterotoxin b-induced proliferation associated with down-expression of cd25 in lymphocytes. | chlamydia pneumoniae (chlamydophila pneumoniae) infects lymphocytes and modulates their immune functions; this is critical in the development of chronic inflammatory diseases associated with this pathogen. therefore, to clarify this immune modulation due to c. pneumoniae infection, the effect of this infection on the proliferation of human peripheral blood lymphocytes was examined. lymphocytes were proliferated by stimulation with staphylococcus aureus enterotoxin b, and the cell number was incr ... | 2010 | 20453895 |
| chlamydia pneumoniae infection and alzheimer's disease: a connection to remember? | alzheimer's disease (ad) is the most common cause of dementia in the elderly, whereby it is customary to distinguish between early familial fad and late-onset ad (load). the development of load, the most prevalent form of ad, is believed to be a multifactorial process that may also involve infections with bacterial or viral pathogens. after the first report on the presence of chlamydia pneumoniae (cpn) in brains of patients with ad appeared in 1998, this bacterium has most often been implicated ... | 2010 | 20445987 |
| the evolving story of chlamydia-induced reactive arthritis. | there have been tremendous recent insights into our understanding of the epidemiology, pathophysiology, and treatment of chlamydia-induced reactive arthritis (cirea). some of these advances embellish our previous understanding of cirea, whereas others suggest that a change in the paradigm is required. | 2010 | 20445454 |
| association of myocardial infarction with mononuclear cell expression of the cytomegalovirus chemokine receptor us28 in patients with niddm. | infectious agents have been linked to atherosclerosis and its acute manifestations; however, little is known about their influence in the context of established risk factors. | 2001 | 20428272 |
| deficiency of xiap leads to sensitization for chlamydophila pneumoniae pulmonary infection and dysregulation of innate immune response in mice. | obligate intracellular chlamydophila pneumoniae induce apoptosis resistance in host cells to escape eradication by immune effector cells. apoptosis resistance depends on the increased expression and stabilization of cellular inhibitor of apoptosis proteins (ciaps) and x-linked inhibitor of apoptosis protein (xiap). here we investigated the role of xiap in experimental pulmonary infection of mice with c. pneumoniae. xiap knock out (ko) mice were sensitized for c. pneumoniae infection compared wit ... | 2010 | 20427267 |
| update on infection and antibiotics in asthma. | asthma pathogenesis seems to be a result of a complex mixture of genetic and environmental influences. there is evidence that mycoplasma pneumoniae and chlamydophila pneumoniae (formerly known as chlamydia pneumoniae) play a role in promoting airway inflammation that could contribute to the onset and clinical course of asthma. evidence also indicates that when antimicrobial therapy can eradicate or suppress these organisms, it may be possible to alter the course of the disease. certain macrolide ... | 2010 | 20425516 |
| [experience accumulated in hospital setting with levofloxacin, in monotherapy and in association therapy]. | levofloxacin possesses a wide antimicrobial spectrum which encompasses gram positive (also including penicillin-resistant streptococcus pneumoniae) and gram negative, and atypical respiratory pathogens chlamydia pneumoniae, legionella pneumophila and mycoplasma pneumoniae) as well. comparative clinical studies (macrolides, beta-lactams, and other fluoroquinolones), have evidenced bacteriological and clinical efficacy in community-acquired pneumonia (cap), acute exacerbation of chronic bronchitis ... | 2009 | 20424535 |
| the acute phase reactant response to respiratory infection with chlamydia pneumoniae: implications for the pathogenesis of atherosclerosis. | the acute phase response to chlamydia pneumoniae infection was analyzed over a 72 h period post-infection in c57bl/6j mice. a single intra-nasal inoculation stimulated statistically significant increases in the plasma levels of il-2, il-5, il-6, il-10, il-12, gm-csf, ifn-gamma, and serum amyloid a but not tnf-alpha, il-1beta, il-4 and serum amyloid p. there was also a decrease in the activity of the hdl protective enzyme paraoxonase as well as a reduced ability of hdl to prevent oxidation of pal ... | 2010 | 20417302 |
| the pathogenic role of chlamydia in spondyloarthritis. | topics relating to the spondyloarthropathies have been reviewed recently, but the detailed roles of chlamydia trachomatis and c. pneumoniae in induction of spondyloarthritis have not been discussed. this review focuses on new information regarding how these pathogens elicit joint disease, with emphasis on c. trachomatis in its role in chlamydia-induced reactive arthritis. | 2010 | 20414116 |
| detection of chlamydia pneumoniae in peripheral blood mononuclear cells of healthy blood donors in tehran regional educational blood transfusion centre. | chlamydia pneumoniae is a common pathogen in the world often causing upper or lower respiratory tract infection and may also be linked to some chronic inflammatory diseases. recent studies have shown that a high percentage of healthy blood donors harbour chlamydia dna and antigens. the objective of this study was to investigate the presence of this microorganism among blood donors. blood samples were collected between november 2004 and march 2005 from 196 healthy blood donors. ten millilitre of ... | 2010 | 20409072 |
| sudden bilateral deafness and chlamydophila infection. | 2010 | 20402619 | |
| [throat infection, neck spinal disease, chest pain and cardiac response: a new clinical syndrome?]. | to analyze the characteristics of a new clinical syndrome, including throat infection, neck spinal disease, chest pain and cardiac response. | 2010 | 20398562 |
| inflammation and fibrosis during chlamydia pneumoniae infection is regulated by il-1 and the nlrp3/asc inflammasome. | chlamydia pneumoniae is a common respiratory pathogen associated with atypical pneumonia, and it has been suggested as a trigger or promoter of several chronic inflammatory conditions, such as asthma and atherosclerosis. the beta form of il-1 (il-1beta) is a proinflammatory cytokine released by many cell types and is an important mediator of inflammation during infection. il-1beta production is a tightly controlled process that includes regulation at multiple levels and typically requires two di ... | 2010 | 20393140 |
| choroidal neovascularization enhanced by chlamydia pneumoniae via toll-like receptor 2 in the retinal pigment epithelium. | choroidal neovascularization (cnv) is directly related to visual loss in persons with age-related macular degeneration (amd) and other macular disorders. chlamydia pneumoniae, a prokaryotic pathogen that causes chronic inflammation, is recognized as a risk factor for cardiovascular diseases. in this study, the authors investigated the association between c. pneumoniae infection and amd using a laser-induced cnv model in mice. | 2010 | 20393111 |
| [clinical investigation of postinfectious cough among adult patients with prolonged cough]. | to prospectively investigate the incidence and clinical findings of "postinfectious cough" among adult patients with prolonged cough, enrolled from july 2006 to june 2008, we studied the serum antibodies of mycoplasma pneumoniae, chlamydophila pneumoniae and bordetella pertussis in those who complained of cough lasting 3-8 weeks but with no abnormalities on their chest x-ray films. mycoplasma pneumoniae bronchitis, chlamydophila pneumoniae bronchitis, and pertussis were diagnosed based on serolo ... | 2010 | 20387520 |
| induction of interferon-stimulated genes by chlamydia pneumoniae in fibroblasts is mediated by intracellular nucleotide-sensing receptors. | recognition of microorganisms by the innate immune system is mediated by pattern recognition receptors, including toll-like receptors and cytoplasmic rig-i-like receptors. chlamydia, which include several human pathogenic species, are obligate intracellular gram-negative bacteria that replicate in cytoplasmic vacuoles. the infection triggers a host response contributing to both bacterial clearance and tissue damage. for instance, type i interferons (ifn)s have been demonstrated to exacerbate the ... | 2010 | 20386592 |
| persistent chlamydophila pneumoniae infection in thoracic aortic aneurysm and aortic dissection? | chlamydophila pneumoniae (c. pneumoniae) has been associated with atherosclerosis and abdominal aortic aneurysm and is probably disseminated by peripheral blood mononuclear cells (pbmc). viable and metabolically active bacteria can be demonstrated by the presence of bacterial mrna and on-going dissemination by the presence of bacteria in pbmc. the aim of this study was to determine the prevalence of c. pneumoniae dna and mrna in aortic biopsies and c. pneumoniae dna in pbmc in thoracic aortic an ... | 2010 | 20384541 |
| detection of chlamydophila pneumoniae in patients with arthritis: significance and diagnostic value. | the aim of this study was to assess the potential clinical implications of chlamydophila pneumoniae in patients with acute and chronic arthritic diseases and to investigate whether blood monocytes might reflect a concomitant synovial or persistent systemic infection. c. pneumoniae was investigated with advanced pcr and reverse transcriptase (rt) pcr techniques targeting different genes and combined with cell line cultures, in synovial fluid (sf) and peripheral blood mononuclear cell (pbmc) speci ... | 2010 | 20383512 |
| stability of chlamydophila pneumoniae in a harsh environment without a requirement for acanthamoebae. | the effect of actual interactions between chlamydophila pneumoniae and amoebae (acanthamoeba) on the survival of c. pneumoniae was investigated. c. pneumoniae and amoebae were detected in 75 soil samples by ifu assay and pcr. although c. pneumoniae could not be cultured, the dna prevalence of c. pneumoniae and amoebae in natural soil was 20% and 92% (no correlation between the prevalence of dna was observed). the viability of c. pneumoniae spiked in autoclaved soil was assessed by ifu assay and ... | 2010 | 20377739 |
| chlamydia pneumoniae infection in polarized epithelial cell lines. | we set up a polarized cell culture model to study the pathogenicity of a common respiratory tract pathogen, chlamydia pneumoniae. immunofluorescence staining of zo-1 (a tight junction protein) and na(+)k(+) atpase (a protein pump localized at the basolateral membrane in the polarized epithelial cells), as well as ter measurements, suggested that the filter-grown calu-3 cells, but not the a549 cells, were polarized when grown on collagen-coated membranes. both the flat and the filter-grown cultur ... | 2010 | 20351147 |
| comparison of five commercial serological tests for the detection of anti-chlamydia trachomatis antibodies. | screening for chlamydia trachomatis-specific antibodies is valuable in investigating recurrent miscarriage, tubal infertility and extrauterine pregnancy. we compared here the performance of immunofluorescence (if) to four other commercial tests in detecting igg antibodies directed against c. trachomatis: two enzyme-linked immunosorbent assays (elisas) using the major outer membrane protein (momp) as the antigen, commercialised respectively by medac and r-biopharm (rb), one elisa using the chlamy ... | 2010 | 20349260 |
| evaluation of false-positive reaction with elisa for the detection of chlamydophila pneumoniae-specific igm antibody in adults. | 2010 | 20332585 | |
| types of infectious outbreaks and their impact in elderly care facilities: a review of the literature. | infectious outbreaks in long-term care facilities (ltcfs) tend to have a significant impact on infection rates and mortality rates of the residents. | 2010 | 20332371 |
| a systemic network for chlamydia pneumoniae entry into human cells. | bacterial entry is a multistep process triggering a complex network, yet the molecular complexity of this network remains largely unsolved. by employing a systems biology approach, we reveal a systemic bacterial-entry network initiated by chlamydia pneumoniae, a widespread opportunistic pathogen. the network consists of nine functional modules (i.e., groups of proteins) associated with various cellular functions, including receptor systems, cell adhesion, transcription, and endocytosis. the peak ... | 2010 | 20233927 |
| chlamydophila pneumoniae downregulates mhc-class ii expression by two cell type-specific mechanisms. | chlamydophila pneumoniae was shown to prevent ifn gamma-inducible upregulation of mhc-class ii molecules by secreting chlamydial protease-like activity factor (cpaf) into the cytosol of those host cells which support the complete bacterial replication cycle. cpaf acts by degrading upstream stimulatory factor 1 (usf-1). however, in cells like bone marrow-derived macrophages (bmm), which restrict chlamydial replication, we show that cpaf expression is barely detectable and the expression of usf-1 ... | 2010 | 20233301 |
| chlamydia pneumoniae igg and iga antibody titers and prognosis in patients with coronary heart disease: results from the claricor trial. | the association observed between coronary heart disease (chd) and chlamydia (chlamydophila) pneumoniae antibodies prompted, during the 1990s, several primary and secondary prevention trials with various antibiotics. in our claricor trial, a randomized placebo-controlled trial in 4372 patients with stable chd, a brief clarithromycin regimen was followed, unexpectedly, by increased long-term mortality. we now compare c. pneumoniae antibody levels at entry with population levels, with the patients' ... | 2010 | 20226329 |
| chlamydophila pneumoniae enhances secretion of vegf, tgf-beta and timp-1 from human bronchial epithelial cells under th2 dominant microenvironment. | chlamydophila pneumoniae infection in the airways is thought to be associated with the pathogenesis of asthma, especially in non-atopic severe asthma with irreversible airway obstruction that may be related to airway remodeling. here, we investigated whether c. pneumoniae infection enhances the secretion of critical chemical mediators for airway remodeling, such as vegf, tgf-beta, and timp-1, in human bronchial epithelial cells (becs) in a th2-dominant microenvironment. | 2010 | 20224677 |
| chlamydia pneumoniae-induced memory cd4+ t-cell activation in human peripheral blood correlates with distinct antibody response patterns. | chlamydia pneumoniae is a frequent pathogen of the respiratory tract, and persistent infections with this obligate intracellular bacterium have been associated with different severe sequelae. although t-cell activation during acute c. pneumoniae infections has been described, little is known about the frequency or the role of the c. pneumoniae-specific memory t cells that reside in the human body after the resolution of the infection. in the present study, the c. pneumoniae-induced t-cell respon ... | 2010 | 20219874 |
| chlamydia pneumoniae infection was associated with risk of mortality from coronary heart disease in japanese women but not men: the jacc study. | to investigate the association between chlamydia pneumoniae infection and mortality from coronary heart disease, a nested case-control study was conducted for 39,242 japanese who participated in the jacc study. | 2010 | 20215711 |
| chlamydophila pneumoniae infection and its role in neurological disorders. | chlamydophila pneumoniae is an intracellular pathogen responsible for a number of different acute and chronic infections. the recent deepening of knowledge on the biology and the use of increasingly more sensitive and specific molecular techniques has allowed demonstration of c. pneumoniae in a large number of persons suffering from different diseases including cardiovascular (atherosclerosis and stroke) and central nervous system (cns) disorders. despite this, many important issues remain unans ... | 2010 | 20182626 |
| the role of infection in carotid plaque pathogenesis and stability: the clinical evidence. | chlamydia pneumoniae was the first pathogen linked with carotid atherosclerotic changes and plaque rupture. currently, other common pathogens are also under investigation as potential contributors. | 2010 | 20180770 |