Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| aviators have been grounded due to the development of asthma. | 1993 | 8447811 | |
| demonstration of chlamydia pneumoniae in atherosclerotic lesions of coronary arteries. | chlamydia pneumoniae is a human respiratory pathogen that causes acute respiratory disease and approximately 10% of community-acquired pneumonia. the infections are geographically widespread. antibody prevalence studies have shown that virtually everyone is infected with the c. pneumoniae organisms at some time and that reinfection is common. in addition to respiratory disease, seroepidemiologic studies have shown an association of this organism with coronary artery disease. c. pneumoniae was de ... | 1993 | 8450249 |
| amplification of chlamydia trachomatis dna by ligase chain reaction. | amplification of chlamydia trachomatis dna by polymerase chain reaction was compared with amplification by ligase chain reaction (lcr). both amplification procedures were able to consistently amplify amounts of dna equivalent to three c. trachomatis elementary bodies. all 15 c. trachomatis serovars were amplified to detectable levels by lcr, and no dna from 16 organisms potentially found in clinical specimens or from chlamydia psittaci and chlamydia pneumoniae was amplified by lcr. | 1993 | 8458974 |
| [association of chlamydia pneumoniae infection with otitis media with effusion]. | chlamydia pneumoniae has recently been recognized to cause various human respiratory tract diseases, including pharyngitis, bronchitis and pneumonia. the most common pathogens of respiratory tract infections such as streptococcus pneumoniae and haemophilus influenzae are frequently present in middle ear effusions. therefore, it is possible that c. pneumoniae play a role in otitis media with effusion (ome). isolation of c. pneumoniae from middle ear aspirates of ome was performed by the culture m ... | 1993 | 8459307 |
| acute lower respiratory tract infection associated with chlamydia pneumoniae in germany. | serum specimens from 223 patients with acute lower respiratory tract infection were examined for antibodies to chlamydia pneumoniae using the microimmunofluorescence test. antibodies to chlamydia pneumoniae were detected in 18 (20%) of 91 children and 64 (48%) of 132 adults. among those individuals, 4 (4%) children and 15 (11%) adults had elevated igg antibody titres indicating acute or recent infection. specific igm antibodies were observed in two patients. these results suggest that a signific ... | 1993 | 8462558 |
| the epidemic cycle of chlamydia pneumoniae infection in eastern finland, 1972-1987. | the epidemic cycle of chlamydia pneumoniae infection was examined in two areas in eastern finland over a period of 15 years, 1972-87. the c. pneumoniae igg antibody prevalence was determined with 5-year intervals in a random sample of the population aged 25-59 years. the total number of sera studied using immunofluorescence was 2387. in 1972 the antibody prevalence was 57% and it increased to 66% in 1977. over the next 5 years the prevalence decreased to 44% in 1982, but by 1987 it had again inc ... | 1993 | 8472779 |
| a mouse model of chlamydia pneumoniae strain twar pneumonitis. | chlamydia pneumoniae is a common cause of acute respiratory infections in humans. we evaluated mice as experimental animals for c. pneumoniae. intranasal inoculation of swiss webster mice with c. pneumoniae induced a prolonged course of lung infection, as demonstrated by reisolation of organisms from lungs (at 42 days) and persistence of lung pathology (> 60 days). the lung pathology was characterized by patchy interstitial pneumonitis with predominantly polymorphonuclear leukocyte infiltration ... | 1993 | 8478091 |
| cell-mediated immunity to chlamydia pneumoniae measured as lymphocyte blast transformation in vitro. | the purpose of the present study was to analyze chlamydia pneumoniae-induced, antigen-specific, cell-mediated immunity. peripheral blood mononuclear cells of four persons infected with c. pneumoniae kajaani 6 and 17 healthy volunteers were stimulated with antigen composed of whole elementary bodies of c. pneumoniae kajaani 6 (cp-ag). definitive antigen-specific lymphoproliferation (lp) responses were developed after recent infection. the lp responses of healthy people to cp-ag varied considerabl ... | 1993 | 8478110 |
| comparison of macrolide antibiotics. | macrolides have been in use since the early 1950s. in recent years new macrolides have been developed to try to overcome the problems associated with erythromycin. in general they have fairly similar in-vitro activity, although azithromycin has superior activity against haemophilus influenzae and some gram-negative organisms. clarithromycin shows superior in-vitro activity against legionella spp. and against the type strain of chlamydia pneumoniae. the pharmacology of macrolides produces many in ... | 1993 | 8478301 |
| serological evidence of the three chlamydial species in an aboriginal community in the northern territory. | to determine the pattern of seropositivity to the three species of chlamydia in women and children from a single community. | 1993 | 8479376 |
| [chlamydia pneumoniae--pathogenesis and perspectives]. | chlamydia pneumoniae, a gram-negative bacterium, formerly named twar but identified as a distinct species since 1988, is now considered to be the most common agent of chlamydial infection in scandinavia. c pneumoniae has a different tissue trophism from that of chlamydia trachomatis, since c pneumoniae may infect bronchi and lungs, macrophages, monocytes, and endothelial cells. c pneumoniae, like other chlamydiae, has a slow, intracellular life cycle. an absence of reaction from the host cells, ... | 1993 | 8480296 |
| chlamydia pneumoniae-specific circulating immune complexes in patients with chronic coronary heart disease. | an association of chronic chlamydia pneumoniae infection to coronary heart disease has been suggested recently. in a recent study, we demonstrated circulating immune complexes containing chlamydial genus-specific lipopolysaccharide in patients with coronary heart disease. the objective of the present study was to investigate whether c. pneumoniae species-specific immune complexes are present in chronic coronary heart disease. | 1993 | 8484830 |
| chlamydia in atherosclerosis. | 1993 | 8484831 | |
| atypical pneumonias. clinical and extrapulmonary features of chlamydia, mycoplasma, and legionella infections. | pneumonias caused by atypical organisms usually have extra-pulmonary features. chlamydial pneumonia often starts with hoarseness and fever, and respiratory tract symptoms may not appear for days. mycoplasmal pneumonia may manifest with ear pain and a nonproductive cough. legionnaires' disease presents with high fevers and central nervous system and gastrointestinal abnormalities. diagnosis of chlamydial infection is accomplished with serologic testing. patients are unresponsive to erythromycin t ... | 1993 | 8493198 |
| in vitro and in vivo antichlamydial activities of newly developed quinolone antimicrobial agents. | the in vitro and in vivo activities of three newly developed quinolone antimicrobial agents (sparfloxacin, tosufloxacin, and opc-17116) were investigated. all three agents showed potent in vitro activities against chlamydia psittaci, c. trachomatis, and c. pneumoniae with mics that ranged from 0.031 to 0.125 micrograms/ml. these values were higher than those of minocycline (0.0075 to 0.015 micrograms/ml) but lower than those of erythromycin (0.25 to 0.5 micrograms/ml) and ofloxacin and ciproflox ... | 1993 | 8494377 |
| detection of chlamydia pneumoniae and chlamydia psittaci in sputum samples by pcr. | to use the polymerase chain reaction (pcr) to detect chlamydia pneumoniae and chlamydia psittaci in sputum samples. | 1993 | 8496387 |
| [chlamydial infections (a review of the literature)]. | 1993 | 8498045 | |
| chlamydial respiratory infections. | 1993 | 8499846 | |
| antibodies to chlamydia species in patients attending a genitourinary clinic and the impact of antibodies to c. pneumoniae and c. psittaci on the sensitivity and the specificity of c. trachomatis serology tests. | in a retrospective study, the prevalence of antibodies to chlamydia trachomatis serovars d to k, c. pneumoniae, and c. psittaci in cases attending a genitourinary clinic was examined. blood samples were collected from 7,002 cases attending the clinic in doncaster, england between may 1983 and may 1990. sera from these samples were tested by a modified microimmunofluorescence test using panels of microdots of egg-grown, purified elementary bodies representing a pool of c. trachomatis d to k, a si ... | 1993 | 8503060 |
| case report: acute postoperative respiratory failure caused by chlamydia pneumoniae and diagnosed by bronchoalveolar lavage. | most chlamydia pneumoniae infections are mild, but 10% develop into pneumonia. c. pneumoniae has been observed in hospital in intubated patients undergoing major surgery or admitted with severe trauma. a patient with squamous cell carcinoma in whom severe pneumonia developed postpneumonectomy and who required mechanical ventilation is presented. the patient was initially treated for nosocomial bacterial pneumonia with the broad spectrum antibiotics ceftazidime, amikacin, and vancomycin. the pati ... | 1993 | 8506900 |
| the morphology of chlamydia pneumoniae. | the morphology of a recently isolated strain of chlamydia pneumoniae, yk-41, was compared by electronmicroscopy with c. pneumoniae twar, chlamydia trachomatis l2/434/bu and chlamydia psittaci cal 10. the results showed that "pear-shaped" morphology was not typical of c. pneumoniae. basic morphological features, such as surface projections and hexagonally arrayed, regular structures in the inside layer of the outer membrane of elementary bodies, were very similar in these strains. the structure o ... | 1993 | 8510134 |
| an unusual manifestation of chlamydia pneumoniae infection: meningitis, hepatitis, iritis and atypical erythema nodosum. | a 37-year-old man was admitted to hospital with fever, muscle tenderness, headache and mild exanthema on the right thigh. during his hospital stay, the headache worsened and aseptic meningitis was diagnosed. a bilateral iritis developed, and the exanthema developed into an atypical erythema nodosum. in liver function tests, pathological results were recorded. vasculitis was suspected but could not be confirmed. all serological tests proved negative except for a fourfold titre rise to chlamydia p ... | 1993 | 8511521 |
| significance of chlamydia pneumoniae (twar) in atherosclerotic lesions. | 1995 | 8521553 | |
| chlamydia pneumoniae (twar) in atherosclerosis of the carotid artery. | chlamydia pneumoniae has been demonstrated in atherosclerotic lesions of coronary arteries and aorta. a seroepidemiological study found c pneumoniae-specific antibody more frequently in persons with significant carotid artery wall thickening than in matched control subjects. | 1995 | 8521559 |
| [various new pathogens in pneumonia]. | the table summarizes the many newly recognized agents causing lower respiratory tract infections: gram + cocci, streptococcus agalactiae, enterococci; gram-rods, acinetobacter, aeromonas hydrophila, eikenella corrodens; mycobacterium tuberculosis resistant to multiple drugs, intracellular organisms and viruses. some details are given in four chapters: pneumococci resistant to penicillin g which must be detected and impose new therapeutic strategies; chlamydia pneumoniae with its difficulties for ... | 1995 | 8525335 |
| [an atypical course of chlamydial infection]. | in burdenko main military clinical hospital 113 patients with acute lung inflammations were examined. according to the data of serological tests with application of indirect immunofluorescent reaction an antibody titer (chlamydia pneumoniae) was disclosed in 9 patients (11% from the whole number of 82 patients). by the authors' opinion bizarre and severe course of chlamydia pneumoniae could take place, thus, it is necessary to conduct serological examinations not only during epidemic outbreaks o ... | 1995 | 8533375 |
| atypical pneumonia. extrapulmonary clues guide the way to diagnosis. | in atypical pneumonia, causative organisms are difficult to isolate, so careful clinical assessment is essential in arriving at a working diagnosis. definitive diagnosis through serologic testing is usually retrospective. either a high initial titer or a fourfold or greater rise between the acute and convalescent titer is considered diagnostic in a patient with compatible illness. legionella and mycoplasma organisms may be cultured from respiratory secretions if plated on appropriate culture med ... | 1996 | 8539198 |
| relevance of chlamydia pneumoniae murine pneumonitis model to evaluation of antimicrobial agents. | a mouse model of chlamydia pneumoniae pneumonitis was established in outbred mf1 mice immunosuppressed with cyclophosphamide. following intranasal inoculation with 2.2 x 10(3) inclusion-forming units of c. pneumoniae tw-183 per mouse, chlamydiae were culturable from the lungs for at least 29 days. progressive subacute pneumonitis with perivascular and peribronchial lymphoid cell hyperplasia was observed, and c. pneumoniae organisms were located in consolidated areas of tissue by immunocytochemis ... | 1995 | 8540698 |
| acute bronchial infection in chronic obstructive pulmonary disease. | bacterial bronchial infection is a frequent cause of copd exacerbation but not its only aetiology. increased purulent expectorant appears to be its best indicator rather than fever, non-productive cough or dyspnoea. the clinician must try to recognize this condition rather than systematically prescribe empirical antibiotics. haemophilus influenzae, streptococcus pneumoniae and moraxella catarrhalis are the major pathogens. although atypical bacteria are not frequent, chlamydia pneumoniae could p ... | 1995 | 8541820 |
| [role of macrolides in the treatment of respiratory tract infections in children]. | macrolides are antibiotics with high intracellular concentrations. they have a bacteriostatic activity but are also bactericides for concentrations five times greater than the minimal inhibitory concentration, concentrations in which they reach in the respiratory tract. they are usually active on streptococcus, neisseria, moraxella catarrhalis, listeria monocytogenes, bordetella pertussis, pasteurella multocida, chlamydia, mycoplasma pneumoniae, legionella pneumophila and helicobacter pylori. th ... | 1995 | 8548000 |
| [serodiagnosis of atypical bacterial respiratory infections]. | since prevalence of antibodies to bacteria causing atypical respiratory infections in israel is as yet unknown, a 5-year antibody prevalence study was performed. seroreactivity to chlamydia pneumoniae (twar), with titers > or = 1:16 by microimmunofluorescence assay (mif) was detected in 725/1305 (55.5%) of patients. 47/1012 ((4.6%) of adult patients had mif results indicating recent infection with twar, (igg titers of > or = 1:512, and/or igm titers of > or = 1:16, and/or seroconversion). antibo ... | 1995 | 8549957 |
| experimental rabbit models of chlamydia pneumoniae infection. | chlamydia pneumoniae (twar), a common cause of acute respiratory disease in humans, has recently been associated with coronary and aortic atherosclerosis. in this study, we evaluated rabbit models of chlamydial infection to investigate the pathogenesis of c. pneumoniae infection. new zealand white rabbits were inoculated intranasally and intratracheally with c. pneumoniae, strain ar-39, and primary and repeated infection were assessed. after a single inoculation, lung pathology was characterized ... | 1996 | 8579129 |
| [chlamydia pneumoniae infection in patients with pneumonia, bronchitis and acute upper respiratory tract infection in beijing]. | a prospective study for c. pneumoniae infection was conducted in 134 patients with acute respiratory disease and 134 matched patients with other medical reasons from january to may 1994 in beijing. the positive rate of micro-if (mif) igg antibodies was 93% (125/134) and 89% (119/134) respectively (0.1 < p < 0.25) and the geometric mean titers (gmt) were not found to be significant (55.9 +/- 4.2 vs 41.7 +/- 2.8, 0.1 < p < 0.20). ten patients, four (4/30) with pneumonia and six (6/81) with bronchi ... | 1995 | 8582186 |
| failure to detect chlamydia pneumoniae in ear fluids from children with otitis media. | 1995 | 8584337 | |
| application of a mycoplasma group-specific pcr for monitoring decontamination of mycoplasma-infected chlamydia sp. strains. | mycoplasma contamination of biological materials remains a major problem. most contaminations are caused by the use of mycoplasma-contaminated cell lines. we adapted a mycoplasma group-specific pcr to detect mycoplasma contamination in cell lines and demonstrate its use in monitoring decontamination procedures with mycoplasma-contaminated suspensions of chlamydia spp. three different methods were investigated: the use of mycoplasma-specific antiserum in cell culture, physical separation by the c ... | 1996 | 8593037 |
| differences in the envelope proteins of chlamydia pneumoniae, chlamydia trachomatis, and chlamydia psittaci shown by two-dimensional gel electrophoresis. | analysis by two-dimensional gel electrophoresis of the n-laurylsarkosinate(sarkosyl)-insoluble envelope complexes of l-[35]s-cysteine-labeled elementary bodies of chlamydia pneumoniae strain iol-207, chlamydia trachomatis serovar lgv2, d, and f, and chlamydia psittaci strain 6bc showed differences in the molecular charges of chlamydial outer membrane proteins. the apparent isoelectric point (pi) of the major outer membrane protein of c. pneumoniae strain iol-207 was 6.4, whereas the pi of the ma ... | 1996 | 8599533 |
| failure to detect chlamydia pneumoniae in coronary atheromas of patients undergoing atherectomy. | to further investigate a proposed relationship between chlamydia pneumoniae and coronary heart disease, coronary atheromas were collected from patients undergoing percutaneous atherectomy. fifty-eight atheroma specimens were examined by culture and polymerase chain reaction (pcr) and 22 by electron microscopy. all were negative for c. pneumoniae, except a single specimen that was pcr-positive. these results differ from studies in other populations, in which this organism was identified by noncul ... | 1996 | 8603977 |
| reactivation of chlamydia pneumoniae infection in mice by cortisone treatment. | reactivation of chlamydia pneumoniae infection was studied by inducing immunosuppression by cortisone acetate treatment given every other day for 14 days in intranasally infected nih/s mice. the treatment started 2 or 4 weeks after primary infection, when no c. pneumoniae was detected. c. pneumoniae could be recovered from the lung cultures on days 7 and 9 in 10 and 60% of the mice, respectively, when cortisone treatment was begun 30 days after infection. these results confirm the persistent nat ... | 1996 | 8606126 |
| replication of chlamydia pneumoniae in vitro in human macrophages, endothelial cells, and aortic artery smooth muscle cells. | chlamydia pneumoniae has recently been associated with atherosclerotic lesions in coronary arteries. to investigate the biological basis for the dissemination and proliferation of this organism in such lesions, the in vitro growth of c. pneumoniae was studied in two macrophage cell lines, peripheral blood monocyte-derived macrophages, human bronchoalveolar lavage macrophages, several endothelial cell lines, and aortic smooth muscle cells. five strains of c. pneumoniae were capable of three passa ... | 1996 | 8613369 |
| c reactive protein and its relation to cardiovascular risk factors: a population based cross sectional study. | to test the hypothesis that minor chronic insults such as smoking, chronic bronchitis, and two persistent bacterial infections may be associated with increases in c reactive protein concentration within the normal range and that variations in the c reactive protein concentration in turn may be associated with levels of cardiovascular risk factors and chronic coronary heart disease. | 1996 | 8616412 |
| evaluation of a direct fluorescent antibody assay for detection of chlamydia pneumoniae. | we examined the utility of the direct immunofluorescent antibody test kit, imagen (dako diagnostic co., ltd.). the stainability of inclusions and purified elementary bodies (ebs) of all the chlamydia pneumoniae strains used in this study was highly specific. immunoelectron microscopy and light microscopy of stained ebs revealed the target antigen of imagen to be located on the surface of the eb outer membrane. in a clinical study, we tested oropharyngeal swab specimens obtained from 41 patients ... | 1996 | 8621963 |
| chlamydia pneumoniae infection in thai children: serological diagnosis. | recent chlamydia pneumoniae infections were investigated in children with respiratory tract infections and in normal children. four groups of sera were tested for c. pneumoniae antibody igg and igm serum fraction by the method of mif test. a total of 7 cases of recent infection were detected, 3 of 116 with pneumonia, 3 of 123 with other respiratory tract infections, 1 of 263 normal school children and none in sera from cord blood. the cases with recent c. pneumoniae infection were as young as 24 ... | 1995 | 8629071 |
| chlamydia linked to atherosclerosis. | 1996 | 8633229 | |
| increased incidence of chlamydia species within the coronary arteries of patients with symptomatic atherosclerotic versus other forms of cardiovascular disease. | the objectives of this study were to test prospectively for an association between chlamydia and atherosclerosis by comparing the incidence of the pathogen found within atherosclerotic plaques in patients undergoing directional coronary atherectomy with a variety of control specimens and comparing the clinical features between the groups. | 1996 | 8636536 |
| epidemiology and control of acute respiratory diseases with emphasis on group a beta-hemolytic streptococcus: a decade of u.s. army experience. | to summarize the experiences of the u.s. army regarding prevention and control, and frequencies, rates, trends, and determinants of febrile acute respiratory diseases (ards), particularly group a beta-hemolytic streptococcus (gabhs). | 1996 | 8637783 |
| [seroprevalence of chlamydia trachomatis infection in std consultants in morocco]. | we have conducted a seroepidemiological survey of chlamydia trachomatis infection among 400 std consultants in comparison with 400 blood donors. the study was performed by using the indirect microimmunofluorescence technique with chlamydia trachomatis, chlamydia psittaci and chlamydia pneumoniae as antigens. the overall seroprevalences were 60% and 46% for std consultants and blood donors respectively. the seroprevalences of chlamydia trachomatis alone were 12.5% for std consultants and 7.5% for ... | 1995 | 8640084 |
| chronic infection and asthma. | 1996 | 8642373 | |
| [familial occurrence of chlamydia pneumoniae infection]. | the clinical courses of six patients involved in a family outbreak of chlamydia pneumoniae respiratory tract infection are described. the diagnosis was established by use of culture, polymerase chain reaction and determination of species specific antibodies. the patients had mild influenza-like symptoms with sore throat, occluded eustachian tubes and long-lasting cough. all patients received recommended antibiotic treatment regimens. two out of the six patients needed further antibiotic treatmen ... | 1996 | 8644428 |
| chlamydia pneumoniae and atherosclerotic plaque. | 1996 | 8648234 | |
| detection and widespread distribution of chlamydia pneumoniae in the vascular system and its possible implications. | to attempt to detect chlamydia pneumoniae dna in atheromatous vascular tissue. | 1996 | 8655672 |
| chlamydia pneumoniae (twar). | chlamydia pneumoniae (twar) is a recently recognized third species of the genus chlamydia that causes acute respiratory disease. it is distinct from the other two chlamydial species that infect humans, c. trachomatis and c. psittaci, in elementary body morphology and shares less than 10% of the dna homology with those species. the organism has a global distribution, with infection most common among children between the ages of 5 and 14 years. in children, twar infection is usually mild or asympt ... | 1995 | 8665464 |
| chlamydia pneumoniae antibodies in chronic obstructive pulmonary disease. | the significance of persistent or recurrent respiratory infections in adult life for the development of chronic obstructive pulmonary disease (copd) is still to a large extent unknown. a few clinical and experimental animal studies suggest that peripheral airways diseases may be due to the cumulative effects of recurrent respiratory infections over an extended period. | 1996 | 8671570 |
| [optimization of the etiological diagnosis and adequate antibacterial therapy in acute disseminated pneumonias]. | analysing literature data and results of the own studies, the authors note, that etiological spectrum of the modern acute widespread pneumonias have modified essentially. the origin of the given pneumonias is determined today by the next pneumotropicous infections: streptococcus pneumoniae, mycoplasma pneumoniae, chlamydia pneumoniae and legionella spp. in this connection prescribing of the modern generation of macrolides to the patients with pulmonary inflammation have been proved to be correct ... | 1996 | 8677643 |
| [unilateral pulmonary edema in an infant]. | 1995 | 8681845 | |
| immune response to chlamydia trachomatis heat-shock protein in infertile female patients and influence of chlamydia pneumoniae antibodies. | a total of 446 sera from 245 patients with primary or secondary infertility, all of whom were examined laparoscopically, 117 patients with chlamydia trachomatis-positive cervical swabs, and 84 control persons (50 obstetric patients and 34 female blood donors) were tested for antibodies to chlamydia trachomatis and to chlamydia pneumoniae with the microimmunofluorescence (mif) test. mif test antibody rates were highest in patients with complete tubal occlusion (73%) and in patients with proven ch ... | 1995 | 8681981 |
| the epidemiology of infectious myocarditis, lymphocytic myocarditis and dilated cardiomyopathy. | infectious myocarditis is a common condition which often passes unrecognized, and the true incidence is thus unknown. lymphocytic myocarditis has been recorded in 1.06% of 12,747 unselected routine autopsies performed over a 10-year period. dilated cardiomyopathy (dcm) has an estimated frequency of 7.5-10% per 100,000 inhabitants per year. overall, the enteroviruses, and particularly the coxsackie-b viruses, predominate among viruses as the cause of myocarditis. as new molecular biological techn ... | 1995 | 8682098 |
| [atypical pneumonias]. | 1996 | 8689016 | |
| chlamydia pneumoniae (twar) infection in tanzanian children. | 1996 | 8693557 | |
| [chlamydia pneumoniae infection associated with autoimmune hemolytic anemia due to warm antibodies]. | chlamydia pneumoniae has often been implicated in respiratory tract infections concomitant with other pathogens. although this agent has also been associated with other nonrespiratory diseases, to our knowledge it has never been described with autoimmune hemolytic anemia. we present a case of pneumonia in which c. pneumoniae was found in association with another important respiratory pathogen, legionella, and with hemolytic autoimmune igg to warm antibodies, an entity that has not been reported ... | 1996 | 8696650 |
| chlamydia pneumoniae pneumonia in hospitalized patients. clinical characteristics and diagnostic value of polymerase chain reaction detection in bal. | to evaluate the incidence and clinical characteristics of chlamydia pneumoniae infection as detected by polymerase chain reaction (pcr) and culture of bal in hospitalized patients with pneumonia, hiv-infected persons, and control subjects. | 1996 | 8697832 |
| chlamydia in coronary plaques--hidden culprit or harmless hobo? | 1996 | 8705849 | |
| [acute community-acquired pneumonia of moderate and grave severity investigated by bronchoscopy. analysis of 193 cases hospitalized in a general hospital]. | between february 1989 and june 1994 193 cases of acute community acquired pneumonia (pac) which were of intermediate or great severity were admitted to two hospitals in the south west of france. these patients were explored using bronchofibroscopy (fb) with a protected brush (bp) and alveolar microlavage (mlba) and quantitative cultures were performed, also there were other specimens taken in a regular fashion. the percentage of positive examinations was 60% for brushings (bp), 59% for mlba and ... | 1996 | 8711237 |
| multiple pathogens in adult patients admitted with community-acquired pneumonia: a one year prospective study of 346 consecutive patients. | the purpose of this study was to assess the causes of community-acquired pneumonia in adult patients admitted to hospital. | 1996 | 8711652 |
| clinical picture of community-acquired chlamydia pneumoniae pneumonia requiring hospital treatment: a comparison between chlamydial and pneumococcal pneumonia. | the importance of chlamydia pneumoniae as a cause of pneumonia has remained controversial. the clinical picture of c pneumoniae and streptococcus pneumoniae in patients admitted to hospital with community-acquired pneumonia was compared during a c pneumoniae epidemic in finland. | 1996 | 8711653 |
| a reverse transcriptase-pcr based assay for in-vitro antibiotic susceptibility testing of chlamydia pneumoniae. | infections caused by chlamydia spp are an important cause of human disease, and the accuracy and reproducibility of antimicrobial susceptibility tests for these bacteria could have considerable clinical implications. we have developed a reverse transcriptase pcr (rt-pcr) based method to determine the antibiotic susceptibility of chlamydia spp., and compared this with conventional tests using immunofluoresence (if) staining. the mics of antimicrobial agents for a test strain of chlamydia pneumoni ... | 1996 | 8722533 |
| chlamydia pneumoniae infection in patients with cystic fibrosis. | the prevalence of atypical community-acquired infections as acute pulmonary exacerbations in patients with cystic fibrosis was prospectively studied. thirty-two patients admitted to the hospital because of acute pulmonary exacerbations and 24 clinically stable patients seen for their routine visits were examined. the prevalence of infection with chlamydia pneumoniae was assessed by culture and serology, and the presence of ige to c. pneumoniae was studied by immunoblotting. a subgroup of patient ... | 1996 | 8722938 |
| ofloxacin versus standard therapy in treatment of community-acquired pneumonia requiring hospitalization. pneumonia study group. | community-acquired pneumonia occurs 3 to 4 million times per year in the united states, accounting for about 500,000 hospitalizations annually. empiric treatment is usually instituted because of a lack of early organism-specific diagnostic tests. this study compared empiric therapy with ofloxacin to standard antibiotic regimens (usually a beta-lactam with or without a macrolide) for patients hospitalized for community-acquired pneumonia. therapy was administered to 298 patients (146 receiving of ... | 1996 | 8723461 |
| acute community-acquired bacterial pneumonia in human immunodeficiency virus (hiv) infected and non-hiv-infected adult patients in cameroon: aetiology and outcome. | yaounde central hospital, jamot hospital, yaounde, and cebec hospital in douala. | 1996 | 8733414 |
| association of chlamydia pneumoniae and acute coronary heart disease events in non-insulin dependent diabetic and non-diabetic subjects in finland. | it has been suggested that chlamydia pneumoniae, a gram-negative intracellular bacterium, is a risk factor for both myocardial infarction and chronic coronary heart disease. previous studies have been done predominantly in non-diabetic subjects and thus the effect of diabetes on the association between c. pneumoniae antibodies and coronary heart disease has not been analysed. the aim of our study was to investigate the association between prior chlamydial infection and the risk of serious corona ... | 1996 | 8737098 |
| chlamydia pneumoniae associated with central nervous system infections. | we identified 15 patients with serological evidence of current chlamydia pneumoniae infection when we studied 263 patients with central nervous system infections among an adult population of 3 million in 1993. in 9 of the 15 patients no other associated or etiological agents were found. one patient died. sequelae appeared in 7 patients. in neurological infections, c. pneumoniae may be more prevalent as an associated agent than appreciated, and adequate antibiotic therapy may be life-saving. | 1996 | 8738947 |
| chlamydia pneumoniae community-acquired pneumonia: a review of 62 hospitalized adult patients. | in a prospective study, chlamydia pneumoniae was identified as the etiological agent in 62 (17.9%) of 346 adult patients hospitalized over the course of one year for community-acquired pneumonia at the soroka medical center in beer-sheva, israel. the diagnosis of c. pneumoniae infection was based on serological testing of antibodies by the mif technique. in 43 of these patients (69.4%), at least one other etiological agent, in addition to c. pneumoniae for community-acquired pneumonia was identi ... | 1996 | 8740101 |
| molecular cloning, sequence analysis, and functional characterization of the lipopolysaccharide biosynthetic gene kdta encoding 3-deoxy-alpha-d-manno-octulosonic acid transferase of chlamydia pneumoniae strain tw-183. | the gene kdta of chlamydia pneumoniae strain tw-183, encoding the enzyme 3-deoxy-alpha-d-manno-octulosonic acid (kdo) transferase of lipopolysaccharide biosynthesis, was cloned and sequenced. a single open reading frame of 1314 bp was identified, the deduced amino acid sequence of which revealed 69% similarity and 43% identity with kdta of chlamydia trachomatis and chlamydia psittaci. the gene was expressed in the gram-positive host corynebacterium glutamicum and the primary gene product was cha ... | 1995 | 8748024 |
| diagnosis of ornithosis by cell culture and polymerase chain reaction in a patient with chronic pneumonia. | we report the case of a woman who had pneumonia due to chlamydia psittaci. a chlamydia species was determined to be the causative agent of the pneumonia because it was isolated from bronchoalveolar lavage fluid, because it could be detected in lung biopsy specimens by the direct immunofluorescence technique, and because chlamydia-specific antibodies could be detected by elisa and microimmunofluorescence. the infectious agent could not be identified at the species level with use of serological te ... | 1995 | 8749643 |
| pneumonia due to chlamydia pneumoniae: prevalence, clinical features, diagnosis, and treatment. | the association of chlamydia pneumoniae with pneumonia was first reported in 1985. this review summarizes the data collected during the subsequent 10 years on the prevalence, clinical features, diagnosis, and treatment of this disease, which is now associated with approximately 10% of all cases of pneumonia worldwide. primary infections are documented most often in schoolchildren and young adults, while reinfections are prominent among the elderly. c. pneumoniae pneumonia is difficult to diagnos ... | 1995 | 8749673 |
| characterization of the murine antibody response to peptides representing the variable domains of the major outer membrane protein of chlamydia pneumoniae. | in an attempt to gain more knowledge about the immunogenicity of the variable domains (vds) of the major outer membrane protein (momp) of chlamydia pneumoniae, peptides representing these areas were used to immunize balb/c and c57bl/6 mice. antisera to the peptides and to peptides conjugated to keyhole limpet hemocyanin (klh) were characterized by their ability to recognize the immunizing peptide and elementary bodies (ebs) of c. pneumoniae by enzyme-linked immunosorbent assay (elisa) and wester ... | 1996 | 8757875 |
| [clinical manifestations of chlamydia pneumoniae infections]. | 1996 | 8760681 | |
| chlamydia pneumoniae and atherosclerosis. | 1996 | 8760682 | |
| relation of c reactive protein to cardiovascular risk factors. h pylori and c pneumoniae infections may account for most acute coronary syndromes. | 1996 | 8761257 | |
| sudden cardiac death in young athletes: orienteering on chlamydia pneumoniae? | 1996 | 8781814 | |
| an increase in sudden unexpected cardiac deaths among young swedish orienteers during 1979-1992. | background: sixteen cases of sudden unexpected cardiac death, 15 males and one female, are known to have occurred among young swedish orienteers from 1979 to 1992, of which seven cases occurred between 1989 and 1992. this is considered to be indicative of an increased death rate. results: histopathological evaluation showed myocarditis in a higher than expected proportion of cases. in one such case, which we studied before the sudden unexpected death occurred, the victim had suffered a chlamydia ... | 1996 | 8781830 |
| chlamydia pneumoniae as a cause of community-acquired pneumonia in hospitalized patients in berlin. | the incidence of community-acquired pneumonia due to chlamydia pneumoniae was evaluated in a 1-year prospective study of 236 hospitalized patients with 237 manifestations of pneumonia. the microbiological diagnosis was based on results of cultures of blood and sputum or bronchoalveolar lavage fluid and results of complement fixation tests and indirect immunofluorescence of acute- and convalescent-phase sera for c. pneumoniae, mycoplasma pneumoniae, legionella species, coxiella burnetii, and resp ... | 1996 | 8783693 |
| lymphocyte subset counts during the course of community-acquired pneumonia: evolution according to age, human immunodeficiency virus status, and etiologic microorganisms. | we investigated the evolution of lymphocyte subsets in blood samples from 94 consecutive patients with community-acquired pneumonia; these samples were obtained 72 hours after hospitalization and at follow-up, when the patients were considered to be cured. acute-phase lymphocyte counts, as compared with follow-up counts, were decreased in the overall population (p < .0001); however, the percentage of cd4+ t cells remained unchanged during the course of pneumonia in each patient. these changes th ... | 1996 | 8783719 |
| in vitro activities of azithromycin, clarithromycin, erythromycin, and tetracycline against 13 strains of chlamydia pneumoniae. | thirteen strains of chlamydia pneumoniae were evaluated for their in vitro susceptibilities to azithromycin, clarithromycin, erythromycin, and tetracycline. the mic ranges were 0.125 to 0.5 micrograms/ml for azithromycin, 0.031 to 1.0 micrograms/ml for clarithromycin, 0.125 to 1.0 micrograms/ml for erythromycin, and 0.25 to 1.0 micrograms/ml for tetracycline. the ranges for the minimal lethal concentrations were 0.125 to 0.5 micrograms/ml for azithromycin, 0.031 to 1.0 micrograms/ml for clarithr ... | 1996 | 8787907 |
| roentgenographic findings of pneumonia caused by chlamydia pneumoniae. a comparison with streptococcus pneumonia. | pneumonia caused by chlamydia pneumoniae or streptococcus pneumoniae cannot be reliably differentiated by clinical signs or symptoms. | 1996 | 8790080 |
| respiratory infections: community-acquired pneumonia and newer microbes. | respiratory infections, especially community-acquired forms of pneumonia (cap), are challenging for clinicians because (1) a causative microorganism can only be found in about 50% of cases; (2) initial therapy, therefore, must be based on a probable or most likely etiology in the context of the patient's overall medical condition; and (3) new microbes or those considered previously as normal flora or less virulent forms seem responsible for some cases. it is important to be acquainted with new c ... | 1996 | 8791258 |
| chlamydia pneumoniae. new diagnostic tools for detection of a common pathogen. | 1996 | 8797397 | |
| detection of serum antibodies against chlamydia pneumoniae by elisa. | chlamydia pneumoniae causes pneumonia and other respiratory infections in children, adolescents and adults. we tried to evaluate the diagnostic value of detection of serum antibodies by elisa for c. pneumoniae infections in japanese children. serum igg, iga and igm antibodies to c. pneumoniae were determined by the microimmunofluorescence (mif) test. serum igg and iga antibodies were also determined by elisa test kits. results obtained by elisa were compared with those obtained by mif test. igg ... | 1996 | 8809554 |
| community-acquired pneumonia in a cohort of former injection drug users with and without human immunodeficiency virus infection: incidence, etiologies, and clinical aspects. | although the association among bacterial pneumonia, human immunodeficiency virus (hiv) infection, and injection-drug use seems to have been well established, accurate estimates of the risk of community-acquired pneumonia among hiv-positive and hiv-negative injection-drug users (idus) are still needed. to estimate the incidence of pneumonia in a community of former idus, we followed 4,236 persons between 1991 and 1994; 1,114 (26.3%) were hiv-positive and 3,122 (73.7%) were hiv-negative. all patie ... | 1996 | 8816138 |
| differentiation of chlamydia spp. by sequence determination and restriction endonuclease cleavage of rnase p rna genes. | the amplification of dna from chlamydia trachomatis by pcr with degenerated primers yielded a 345-bp fragment of the putative rnase p rna gene. from the deduced dna sequence of this gene in c. trachomatis, a modified primer pair was designed. the primer pair was subsequently used to obtain the corresponding gene products from chlamydia pneumoniae and chlamydia psittaci. sequence comparisons revealed similarities of 76.6% between c. trachomatis and c. pneumoniae, 79.5% between c. trachomatis and ... | 1996 | 8818877 |
| serum gamma-interferon in patients with pneumonia caused by chlamydia pneumoniae. | 1996 | 8822295 | |
| detection of serum antibodies against chlamydia pneumoniae by in vitro neutralization and microimmunofluorescence assays. | antibodies to chlamydia pneumoniae (iol-207) were studied by the microimmunofluorescence (mif) assay and in vitro neutralization in serum samples from 230 healthy adults and 332 patients at risk of c. pneumoniae infection. in the mif test, the prevalence of immunoglobulin g (igg) antibody was 53.9% among healthy subjects and 40.7% in the patients. an mif antibody titre of > or = 1 : 512, consistent with acute infection by c. pneumoniae was documented in 23 out of 332 patients, and in none of the ... | 1996 | 8837368 |
| synchronous variations of the incidence of temporal arteritis and polymyalgia rheumatica in different regions of denmark; association with epidemics of mycoplasma pneumoniae infection. | the etiology of temporal arteritis (ta) and polymyalgia rheumatica (pmr) is unknown, but the sudden onset and the wide variation in incidence reported from various parts of the world suggest the existence of environmental and/or genetic factors. we studied the incidence of ta and pmr during a 12 year period in different regions of denmark. | 1996 | 8838518 |
| two cases of lower respiratory tract infection due to chlamydia pneumonia in singapore. | chlamydia pneumoniae, previously known as chlamydia psittaci strain twar, causes both upper and lower respiratory tract infection. we report the first two cases of culture-positive chlamydia pneumoniae lower respiratory infection in singapore. both patients had underlying fibrosing alveolitis and presented with a history of prolonged productive cough and fever. chlamydia pneumoniae was isolated from the bronchoalveolar lavage fluid in the absence of other pathogens. the patients responded clinic ... | 1995 | 8838997 |
| detection of chlamydia pneumoniae in atheroma specimens. | 1996 | 8843240 | |
| in vitro activities of azithromycin and doxycycline against 15 isolates of chlamydia pneumoniae. | fourteen isolates of chlamydia pneumoniae, 12 from clinically ill patients and 2 from subjectively healthy individuals from an area within a 400-km proximity of gävle, sweden, and strain iol-207, originally from the eye of an iranian child, were tested for susceptibilities to the antibiotics doxycycline and azithromycin. mics and minimum chlamydiacidal concentrations were found to correlate well with values reported earlier by other investigators. in addition to mic and minimum chlamydiacidal co ... | 1996 | 8843291 |
| chlamydia trachomatis as a possible cofactor for kaposi's sarcoma in aids. | aids-associated kaposi's sarcoma (ks) is much more frequent in patients acquiring hiv infection via the sexual route. epidemiological studies have confirmed the likely involvement of a sexually acquired cofactor in the pathogenesis of this form of ks. we have formulated a set of postulates, epidemiological and experimental, to fit a single unifying hypothetical agent. chlamydia trachomatis is one of 3 agents to fit the epidemiological criteria. our data suggest a possible association between inc ... | 1995 | 8845400 |
| [cough, fever and exanthema]. | we report on a 29-year-old female patient who developed a dolent nodular exanthema on both lower legs after a prolonged respiratory infection of about 14 days. the chest x-ray showed a distinct enlargement of the left hilus and reduced transparency in the left upper pulmonary lobe. these findings were interpreted as pneumonia with para-infectious erythema nodosum. the serology showed igm antibodies against chlamydia pneumoniae. therapy with a macrolide antibiotic led to a rapidly improved genera ... | 1996 | 8848662 |
| development of a simplified polymerase chain reaction-enzyme immunoassay for the detection of chlamydia pneumoniae. | the 16s rrna genes of two chlamydia pneumoniae and two c. psittaci strains of different serovars were sequenced then compared to previously reported chlamydia 16s rrna gene sequences. chlamydia pneumoniae-specific regions were identified and specific primers for nested pcr were synthesized. nested pcr reactions were performed, in a single tube, by varying the annealing temperature of the amplification cycles. the initial thermal cycles were selected to allow annealing and extension of only the o ... | 1996 | 8849645 |
| persistent chlamydia pneumoniae infection in a swedish family. | chlamydia pneumoniae, an etiological agent for respiratory tract infection, was found as a cause of persistent infection in a family group. during the observation period of 2 1/2 years, serology and polymerase chain reaction for c. pneumoniae demonstrated a failure to eradicate the organism, despite several prolonged courses of antibiotics known to be effective against chlamydia species. | 1996 | 8863360 |
| chlamydial infection in a population of ethiopian women attending obstetric, gynaecological and mother and child health clinics. | the prevalence of chlamydial infection was assessed in 1,846 ethiopian women attending clinics in addis ababa. sera were tested for type-specific anti-chlamydial antibodies using purified chlamydial antigens (c. trachomatis a-c (cta-c), c. trachomatis d-k (ctd-k), lymphogranuloma venereum (lgvi-3), and c. pneumoniae (cpn), in a micro-immunofluorescence (micro-if) test. three levels of chlamydial infection were established. sera with: 1) antibodies to cta-c, ctd-k, lgv 1-3 and cpn singly or in co ... | 1996 | 8868379 |