Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| [chlamydia pneumonia and atherosclerosis]. | 1999 | 10347632 | |
| effect of azithromycin plus rifampin versus that of azithromycin alone on the eradication of chlamydia pneumoniae from lung tissue in experimental pneumonitis. | azithromycin, doxycycline, and rifampin, alone or in combination, were tested in vitro against chlamydia pneumoniae ar-39. the combination of azithromycin plus rifampin showed the strongest activity and produced higher rates of eradication of c. pneumoniae from lung tissues than azithromycin alone in experimental mouse pneumonitis. | 1999 | 10348778 |
| [chlamydia pneumoniae in patients with acquired pneumonia in the santiago of chile community]. | the prevalence of chlamydia pneumoniae infection varies according to the population and geographic area studied. | 1998 | 10349163 |
| infectious agents that play a role in atherosclerosis and vasculopathies. what are they? what do we do about them? | much of the published data suggest a link between herpes infection and atherosclerosis, as well as herpes infection and restenosis. mechanistically, herpesvirus has been shown to promote inflammation, thrombin generation and platelet binding, and infected cells have been shown to be resistant to apoptosis. there is also good evidence of a link between chlamydia pneumoniae infection and atherosclerosis. in preliminary studies, antichlamydial antibiotic intervention has been shown to reduce signif ... | 1999 | 10350677 |
| value of the polymerase chain reaction assay in noninvasive respiratory samples for diagnosis of community-acquired pneumonia. | we studied the causes of community-acquired pneumonia (cap) in 184 patients. microbiologic evaluation included sputum examination, blood culture, assessment of acute and convalescent antibody titers for legionella pneumophila, mycoplasma pneumoniae, chlamydia pneumoniae, coxiella psitacci, coxiella burnetii and respiratory viruses, polymerase chain reaction (pcr) assays for m. pneumoniae and c. pneumoniae in throat swab, and pcr assay based on the amplification of pneumolysin gene fragment in se ... | 1999 | 10351932 |
| relation between direct detection of chlamydia pneumoniae dna in human coronary arteries at postmortem examination and histological severity (stary grading) of associated atherosclerotic plaque. | numerous studies have suggested a link between chlamydia pneumoniae infection, atherosclerosis, and coronary artery disease. however, it is still unclear whether c pneumoniae plays a causal role in the pathogenesis of these conditions. accordingly, we have performed a systematic dissection of the 3 coronary arteries on 33 postmortem subjects and studied the relationship in individual artery segments between the presence of c pneumoniae dna and the severity of associated atherosclerosis. | 1999 | 10351965 |
| induction of hla class i-restricted cd8+ ctls specific for the major outer membrane protein of chlamydia trachomatis in human genital tract infections. | hla class i-restricted cd8+ ctls specific for the major outer membrane protein (momp) of chlamydia trachomatis are present in the peripheral blood of humans who acquired genital tract infections with the organism. three hla-a2-restricted epitopes and two hla-b51-restricted epitopes were identified in serovar e-momp. one of the five epitopes spans a variable segment of momp and is likely a serovar e-specific epitope. the other four epitopes are localized in constant segments and are c. trachomati ... | 1999 | 10352308 |
| chlamydia pneumoniae infection accelerates the progression of atherosclerosis in apolipoprotein e-deficient mice. | accumulating evidence supports an association between chlamydia pneumoniae infection and atherosclerosis. to determine whether there is a causal relationship, the effects of chronic infection with c. pneumoniae on the development of atherosclerosis in apolipoprotein e (apoe)-deficient mice were evaluated. eight-week-old male apoe-deficient mice were inoculated intranasally with c. pneumoniae three times, at 8, 9, and 10 weeks of age. the combined area of atherosclerotic lesions in the lesser cur ... | 1999 | 10353889 |
| chlamydia pneumoniae-reactive t lymphocytes in abdominal aortic aneurysms: the smoking gun? | 1999 | 10354205 | |
| chlamydia pneumoniae reactive t lymphocytes in the walls of abdominal aortic aneurysms. | the presence of chlamydia pneumoniae in the walls of abdominal aortic aneurysms (aaas) has been demonstrated recently, but its role in the cause and/or maintenance of aortic wall inflammation is not known. in the present study, we have investigated the possible relationship between c. pneumoniae and the antigen specificity of t lymphocytes mediating inflammation in aaa tissue. | 1999 | 10354217 |
| immunoglobulin a antibodies against chlamydia pneumoniae are associated with expansion of abdominal aortic aneurysm. | the aim of this study was to examine the possible association between the progression of small abdominal aortic aneurysm (aaa) and chronic infection with chlamydia pneumoniae. | 1999 | 10361184 |
| vascular surgical society of great britain and ireland: immunoglobulin a antibodies against chlamydia pneumoniae are associated with expansion of small abdominal aortic aneurysms and declining ankle blood pressure | background: the potential correlation between chronic infection with chlamydia pneumoniae and the progression of small abdominal aortic aneurysms (aaas) and lower limb atherosclerosis was studied. methods: mass screening for aaa was carried out in outdoor clinics at all hospitals in the county. some 139 men (aged 65-73 years) with a 3.0-4.9-cm aaa were followed prospectively for 1-3 (mean 2.7) years. initially, an interview and examination was performed, and blood samples were taken. results: so ... | 1999 | 10361204 |
| [chlamydia pneumoniae pneumonia. radiographic features in a patient with lung transplantation]. | 1999 | 10363065 | |
| chlamydia pneumoniae in a free-ranging giant barred frog (mixophyes iteratus) from australia. | the koala biovar of chlamydia pneumoniae was identified in lung tissue from a sick, free-ranging giant barred frog (mixophyes iteratus) by using electron microscopy, c. pneumoniae-specific fluorescent-antibody staining, cell culture, and sequencing of the ompa, ompb and 16s rrna genes. this is the first report of a chlamydial strain infecting both a homeotherm and a poikilotherm and only the fourth host (in addition to humans, koalas, and horses) to be naturally infected with this species of chl ... | 1999 | 10364623 |
| chlamydia trachomatis nucleic acids can be found in the synovium of some asymptomatic subjects. | the recent identification of antigens or nucleic acids of infectious agents in the joints of patients with reactive arthritis has raised questions about whether chlamydial or other infectious agent nucleic acids are also present in normal joints. we had the opportunity to study synovium from 30 asymptomatic volunteer subjects by use of polymerase chain reaction (pcr) for attempted identification of chlamydia and other infectious agents. | 1999 | 10366123 |
| antibiotics and heart disease. the story heats up. | 1999 | 10368527 | |
| chlamydia pneumoniae and coronary heart disease. | to review the potential association between chlamydia pneumoniae (cp) infection and coronary artery disease (cad), and to describe possible therapeutic interventions. | 1999 | 10369627 |
| chlamydia pneumoniae as a triggering infection in reactive arthritis. | to determine the role of chlamydia pneumoniae as a triggering infection in reactive arthritis (rea). | 1999 | 10371278 |
| in vitro hyperreactivity to lipopolysaccharide in patients with history of unstable angina is not associated with seropositivity for cytomegalovirus, helicobacter pylori and chlamydia pneumoniae. | inflammation and possibly chronic infections are associated with acute coronary syndromes; however, the mechanisms responsible for this association are not yet fully elucidated. the aim of this study was to assess whether the hyperreactivity of the inflammatory system, that we have shown in unstable patients with persistently elevated c-reactive protein and with recurrence of symptoms, was associated with chronic infection. | 1999 | 10371790 |
| azithromycin: single 1.5 g dose in the treatment of patients with atypical pneumonia syndrome--a randomized study. | an open comparative study was undertaken in order to assess the efficacy and safety of a single dose of azithromycin in the treatment of community-acquired atypical pneumonia. a total of 100 adult patients with atypical pneumonia syndrome were randomized to receive 1.5 g of azithromycin as a single dose, or 500 mg once daily for 3 days. the presence of mycoplasma pneumoniae, chlamydia pneumoniae, chlamydia psittaci, coxiella burnetii, and legionella pneumophila infection was diagnosed by serolog ... | 1999 | 10378132 |
| evidence of 2 waves of chlamydia pneumoniae infection in gävle, sweden, 1990-96. | chlamydia pneumoniae is a common respiratory tract pathogen. the majority of adults have serological evidence of previous exposure. most infections are probably asymptomatic or subclinical. recent studies have implicated c. pneumoniae as a risk factor for the development of cardiovascular disease. it was therefore of interest to study new blood donors collected between the years of 1990 and 1996 for the purpose of delineating the epidemiological situation in the gävle area of sweden. sera from a ... | 1999 | 10381224 |
| seroprevalence of chlamydia pneumoniae in chile. | we used microimmunofluorescence to survey the prevalence of antibodies to chlamydia pneumoniae in 403 serum samples from asymptomatic subjects aged 6 months to 89 y in santiago, chile. the results suggest that chlamydia pneumoniae infection is endemic in chile, with a seroprevalence of 60% which does not differ by gender. | 1999 | 10381230 |
| [assay of specific anti-chlamydia pneumoniae antibodies by elisa method. 3. setting of serological criteria]. | "hitazyme c. pneumoniae" (or "hitazyme cpn", for short) is a diagnostic reagent that has been recently developed by adopting an elisa method for detection of anti-chlamydia pneumoniae (c. pneumoniae) antibodies. when this reagent is used under a current diagnostic standard that has been set as a provisional standard, however, high antibody positive rates are often produced for both igg and iga even using the specimens of healthy persons. so, it is difficult to distinguish c. pneumoniae-infected ... | 1999 | 10386026 |
| in vitro susceptibilities of chlamydia pneumoniae isolates from german patients and synergistic activity of antibiotic combinations. | the susceptibilities of six chlamydia pneumoniae type strains and of six german patient isolates to erythromycin, azithromycin, roxithromycin, clarithromycin, doxycycline, ofloxacin, and rifampin were investigated. mics and minimal chlamydicidal concentrations were all within the ranges reported previously. combinations of azithromycin with either ofloxacin, doxycycline, or rifampin, as well as combinations of three antibiotics (rifampin, azithromycin, and ofloxacin or doxycycline), showed syner ... | 1999 | 10390251 |
| acute purulent exacerbation of chronic obstructive pulmonary disease and chlamydia pneumoniae infection. | in order to investigate the role of bacteria, including mycoplasma pneumoniae and especially chlamydia pneumoniae in acute purulent exacerbations of chronic obstructive pulmonary disease (copd), we examined sputum specimens and acute and convalescent sera taken 26 d apart from 49 outpatients experiencing an acute purulent exacerbation of copd. the sera were tested for antibodies to c. pneumoniae with the microimmunofluorescence test, and for antibodies to m. pneumoniae with the indirect fluoresc ... | 1999 | 10390424 |
| microbial etiology and bacterial resistance. | the nature of the causative organisms involved in community-acquired pneumonia has always attracted the interest of investigators. despite multiple studies using different methodological approaches, it remains a matter of controversy because a reliable cause cannot be obtained in a significant percentage of cases, even when using more sophisticated diagnostic procedures. the recent discovery of new pathogens such as the legionella species or chlamydia pneumoniae, highly prevalent worldwide shows ... | 1999 | 10391406 |
| community-acquired pneumonia in the elderly. | the incidence of community-acquired pneumonia (cap) in the elderly is higher compared to younger populations. in addition, pneumonia in the elderly is a life-threatening problem. as our demographics have changed, clinicians have developed a heightened interest in managing pneumonia in the elderly. the development of pneumonia in elderly patients differs from that in younger individuals due to a complex array of factors. (1) the organisms involved depend on the setting in which the pneumonia deve ... | 1999 | 10391411 |
| atherosclerosis is not an infectious process. | 1999 | 10393403 | |
| the species specificity of the microimmunofluorescence antibody test and comparisons with a time resolved fluoroscopic immunoassay for measuring igg antibodies against chlamydia pneumoniae. | to examine the species specificity of the microimmunofluorescence test (mif) and assess a time resolved fluoroscopic immunoassay (tria) for measuring igg antibodies to c pneumoniae. | 1999 | 10396235 |
| strong correlation between helicobacter pylori seropositivity and chlamydia pneumoniae igg concentrations. | 1998 | 10396525 | |
| demonstration of viable chlamydia pneumoniae in atherosclerotic plaques of carotid arteries by reverse transcriptase polymerase chain reaction. | the presence of chlamydia pneumoniae in atheromas has been demonstrated in several studies. culture of the organism from arterial tissue has been difficult. we report the use of a reverse transcriptase polymerase chain reaction to detect viable chlamydia pneumoniae in carotid atheromas. we analyzed 30 patients (14 females, mean age 69.6 +/- 8.8 years) who underwent surgery for the removal of atherosclerotic plaques from carotid arteries. during surgery, samples of lingual vein and superior thyro ... | 1999 | 10398739 |
| does persistent infection with chlamydia pneumoniae increase the risk of atherosclerosis in chronic renal failure? | 1999 | 10400517 | |
| chlamydia pneumoniae infection of the central nervous system in multiple sclerosis. | our identification of chlamydia pneumoniae in the cerebrospinal fluid (csf) of a patient with multiple sclerosis (ms) led us to examine the incidence of this organism in the csf from 17 patients with relapsing-remitting ms, 20 patients with progressive ms, and 27 patients with other neurological diseases (ond). csf samples were examined for c pneumoniae by culture, polymerase chain reaction assays, and csf immunoglobulin (ig) reactivity with c pneumoniae elementary body antigens. c pneumoniae wa ... | 1999 | 10401775 |
| chlamydia pneumoniae infection and ethnic origin. | to test the association of chlamydia pneumoniae infection with ethnic origin. | 1998 | 10403105 |
| comparative in-vitro activity of moxifloxacin, minocycline and azithromycin against chlamydia spp. | the in-vitro activity of moxifloxacin, a new 8-methoxyquinolone, was compared with minocycline and azithromycin against 40 strains of chlamydia trachomatis, chlamydia pneumoniae and chlamydia psittaci. both the mic and the mbc of moxifloxacin ranged from 0.03 to 0.125 mg/l. mics of minocycline ranged from 0.015 to 0.06 mg/l and mbcs between 0.03 and 0.25 mg/l. mics of azithromycin ranged from 0.03 to 0.125 mg/l and the mbcs between 0.06 and 0.5 mg/l. mbc values of moxifloxacin were the same as m ... | 1999 | 10404322 |
| association of cervical artery dissection with recent infection. | cervical artery dissection (cad) is an important cause of ischemic stroke in younger patients. however, its cause is insufficiently understood. | 1999 | 10404987 |
| association of seropositivity for chlamydia pneumoniae and coronary artery disease in heterozygous familial hypercholesterolaemia. | in patients with familial hypercholesterolaemia heterozygous for the north karelia (finland) mutation, the presence of unequivocal coronary heart disease was significantly associated with high titres of igg and iga antibodies to chlamydia pneumoniae. | 1999 | 10406370 |
| chlamydia pneumoniae infection and incident coronary heart disease: the atherosclerosis risk in communities study. | pathologic findings and cross-sectional epidemiologic studies suggest that past infection with chlamydia pneumoniae is associated with clinical and subclinical atherosclerotic disease, although evidence from prospective studies is still scarce. the association between chronic infection by c. pneumoniae and incident coronary heart disease (chd) was investigated in a case-cohort study conducted among participants in the atherosclerosis risk in communities study who were free of chd at the baseline ... | 1999 | 10412959 |
| how useful is the chlamydia micro-immunofluorescence (mif) test for the gynaecologist? | three patients with a chlamydial respiratory tract infection showed significant titre rises for the three chlamydial micro-immunofluorescence tests, performed with chlamydia pneumoniae, c. psittaci and c. trachomatis. such cross-reactions procure an inaccurate discrimination between the various chlamydia species which remains speculative anyhow when only a positive serological profile against one chlamydial subspecies is performed. we consider that using the serologic assay as proof for past sex ... | 1999 | 10413220 |
| activity of grepafloxacin and other fluoroquinones and newer macrolides against recent clinical isolates of chlamydia pneumoniae. | chlamydia pneumoniae is a frequent cause of community-acquired respiratory tract infection including pneumonia and bronchitis. quinolones have attracted interest as potential therapy for community-acquired respiratory tract infections because they are active against a wide range of pathogens including c. pneumoniae and mycoplasma pneumoniae. the in vitro susceptibilities of c. pneumoniae were determined for grepafloxacin, levofloxacin, moxifloxacin, trovafloxacin, clarithromycin and azithromycin ... | 1999 | 10418764 |
| genomic relatedness of chlamydia isolates determined by amplified fragment length polymorphism analysis. | the genomic relatedness of 19 chlamydia pneumoniae isolates (17 from respiratory origin and 2 from atherosclerotic origin), 21 chlamydia trachomatis isolates (all serovars from the human biovar, an isolate from the mouse biovar, and a porcine isolate), 6 chlamydia psittaci isolates (5 avian isolates and 1 feline isolate), and 1 chlamydia pecorum isolate was studied by analyzing genomic amplified fragment length polymorphism (aflp) fingerprints. the aflp procedure was adapted from a previously de ... | 1999 | 10419941 |
| [chlamydia pneumoniae pneumonia]. | chlamydia pneumoniae causes respiratory tract infections, and it is transmitted by air and fomites. it is probably more frequent than it is described, due to asymptomatic or mild symptomatic patients. they respond to macrolides, tetracyclines and quinolones, though patients may recover slowly. an increase of the incidence of pneumonia, caused by chlamydia pneumoniae, is shown in recent multicenter surveys, being even more frequent than streptococcus pneumoniae and mycoplasma pneumoniae. recently ... | 1998 | 10420952 |
| infection and atherosclerosis: emerging mechanistic paradigms. | although definitive proof of a causal role of infection contributing to atherogenesis is lacking, multiple investigations have demonstrated that infectious agents evoke cellular and molecular changes supportive of such a role. moreover, both chlamydia pneumoniae and cytomegalovirus exacerbate lesion development in animal models of atherosclerosis and restenosis. the fact that multiple pathogens have been associated with atherosclerosis implies that many "atherogenic" pathogens exist, and recent ... | 1999 | 10421626 |
| from plaque biology to clinical setting. | coronary atherosclerosis may cause acute and chronic ischemic syndromes; the former are caused by "acute plaque events," mostly thrombosis complicating vulnerable ruptured plaques, namely severe lesions with large core, thin cap, and weak shoulder infiltrated by activated inflammatory cells. plaque rupture may also occur in nonischemic settings and is not obligatorily complicated by thrombosis. furthermore, plaque rupture is not the only thrombus substrate in acute ischemic syndromes: superficia ... | 1999 | 10426860 |
| chlamydia pneumoniae antibodies and angiographically demonstrated coronary artery disease in a sample population from italy. | recent reports suggest an association between chlamydia pneumoniae and chronic coronary heart disease. this case-control study investigates the relationship between the presence of immunoglobin g (igg) and immunoglobin a (iga) when measured by means of microimmunofluorescence (mif) and angiographically diagnosed coronary disease. cases (n = 150) were angiography patients with at least one coronary artery lesion occupying at least 50% of the luminal diameter. controls (n = 49) were angiography pa ... | 1999 | 10428298 |
| etiology of community-acquired pneumonia: impact of age, comorbidity, and severity. | the aim of this study was to determine the etiology of community-acquired pneumonia (cap) and the impact of age, comorbidity, and severity on microbial etiologies of such pneumonia. overall, 395 consecutive patients with cap were studied prospectively during a 15-mo period. regular microbial investigation included examination of sputum, blood culture, and serology. sampling of pleural fluid, transthoracic puncture, tracheobronchial aspiration, and protected specimen brush (psb) sampling were per ... | 1999 | 10430704 |
| cellular oxidation of low-density lipoprotein by chlamydia pneumoniae. | a spectrum of clinical and epidemiologic studies implicate infectious agents, including chlamydia pneumoniae, in the pathogenesis of atherosclerosis. the complexity of atherosclerotic disease necessitates examining the role of infection in the context of defined risk factors, such as high levels of native low-density lipoprotein (ldl). although native ldl does not have atherogenic properties, cellular oxidation of ldl alters the lipoprotein into a highly atherogenic form. in this report, c. pneu ... | 1999 | 10438367 |
| antibodies to chlamydia trachomatis heat shock proteins in women with tubal factor infertility are associated with prior infection by c. trachomatis but not by c. pneumoniae. | the antibody response to heat shock proteins 60 and 10 were studied in 163 patients with tubal factor infertility and in 163 age-matched pregnant women. the associations of these antibodies with specific antibodies to chlamydia trachomatis and to chlamydia pneumoniae as well as with antibodies to the common chlamydial lipopolysaccharide antigen were studied. patients with tubal factor infertility had significantly higher frequencies and titres of all antibodies except to c. pneumoniae. in a logi ... | 1999 | 10438411 |
| detection of viral, chlamydia pneumoniae and mycoplasma pneumoniae infections in exacerbations of asthma in children. | a high frequency of virus infections has been recently pointed out in the exacerbations of asthma in children. | 1999 | 10443789 |
| chlamydial antibodies in an elderly finnish population. | the characteristic feature of chlamydia is its tendency to cause chronic infections. it has been hypothesized that prior exposure to c. pneumoniae may lead to chronic infection and the development of associated chronic cardiopulmonary disease. few studies have so far addressed the occurrence of chlamydial antibodies in an elderly, unselected population. this information is important for the development of possible treatment strategies. chlamydial antibodies were analysed from 1179 serum samples ... | 1999 | 10447321 |
| depletion of cd8+ cells abolishes memory in acquired immunity against chlamydia pneumoniae in balb/c mice. | the importance of t cells in chlamydia pneumoniae infection in mice was assessed by comparing wild-type balb/c mice with nude mice and mice depleted in vivo of either cd4+ or cd8+ t cells. whereas wild-type mice cleared the primary infection in 3 weeks, nude mice were only able to restrict the infection and could not clear it during the observation period of 56 days. nude mice exhibited a greater number of macrophages in their lungs and the pulmonary cells secreted a higher level of tumour necro ... | 1999 | 10447772 |
| legionella, chlamydia pneumoniae and mycoplasma infection in patients admitted to christchurch hospital with pneumonia. | to determine the incidence, clinical features and outcome of community acquired pneumonia caused by mycoplasma pneumoniae, legionella species, coxiella burnetti, chlamydia pneumoniae and chlamydia psittaci requiring admission to hospital. | 1999 | 10448994 |
| conservation of putative promoter sequences located upstream of chlamydial major sigma factor gene, siga among chlamydia spp. | a highly conserved 40-nucleotide sequence was identified. two completely conserved sequences, tagatt and taaact, separated by 17 nucleotides resemble the consensus sequence recognized by the escherichia coli major sigma factor and sequence found in other chlamydial promoters. in addition, the adenine-rich sequence present in many chlamydial promoters was also conserved upstream of the putative -35 element. these findings suggest that the conserved sequence may play a role in the regulatory funct ... | 1999 | 10449248 |
| low prevalence of chlamydia pneumoniae in atherectomy specimens from patients with coronary heart disease. | coronary atherectomy specimens from 50 patients with coronary heart disease were examined for the presence of chlamydia pneumoniae by two different methods of polymerase chain reaction (pcr) and by in situ hybridization. c. pneumoniae dna was detected by pcr in atherosclerotic plaques of four patients (8%). two patients' coronary atheromas were positive, both by a single-step 16s rrna-based pcr and by an omp1-based nested pcr. the other two patients' specimens were positive only by the nested pc ... | 1999 | 10452622 |
| the role of chlamydia pneumoniae in atherosclerosis. | 1999 | 10452623 | |
| chlamydia pneumoniae infection and early asymptomatic carotid atherosclerosis. | chronic chlamydia pneumoniae infection has been implicated in the pathogenesis of atherosclerosis but whether it plays a role at an early stage in the disease is uncertain. an early estimate of atherosclerosis can be obtained by ultrasonic imaging of the carotid artery to determine intima-media thickness (imt) and the thickness of any atheroma plaques. | 1999 | 10458719 |
| etiology of acute lower respiratory tract infection in central australian aboriginal children. | aboriginal children in central australia have attack rates for acute lower respiratory tract infection (alri) that are similar to those in developing countries. although mortality rates are much lower than in developing countries, morbidity is high and alri is still the leading cause of hospitalization. however, there are no data on the etiology of alri in this population. | 1999 | 10462342 |
| in vitro activities of azithromycin and ofloxacin against chlamydia pneumoniae in a continuous-infection model. | chlamydia pneumoniae is a well-established cause of community-acquired pneumonia and bronchitis in adults and children. chronic infections with c. pneumoniae have been implicated in the development of atherosclerosis and other diseases in humans. methods currently used for the culture and propagation of c. pneumoniae are not analogous to the infection as it occurs in vivo. we have established a model of continuous c. pneumoniae infection in vitro. hep-2 cells inoculated with cm-1 and tw-183 stra ... | 1999 | 10471577 |
| can infections cause heart attacks? | 1999 | 10472205 | |
| antimicrobial therapy for chlamydia pneumoniae: its potential role in atherosclerosis and asthma. | 1999 | 10473220 | |
| multiplex polymerase chain reaction for the simultaneous detection of mycoplasma pneumoniae, chlamydia pneumoniae, and chlamydia psittaci in respiratory samples. | to develop a multiplex polymerase chain reaction (pcr) for the simultaneous detection of mycoplasma pneumoniae, chlamydia pneumoniae, and chlamydia psittaci in respiratory samples. | 1999 | 10474515 |
| clinical characteristics of chlamydia pneumoniae infection as the sole cause of community-acquired pneumonia. | the clinical characteristics of 26 patients with community-acquired pneumonia due to chlamydia pneumoniae as the only identified pathogen who required hospitalization were evaluated. most patients (18) had reinfection based on serological results. the mean age of the patients was 55 years (38 years, patients with primary infection; 63 years, patients with reinfection), and the gender representation was equal. generally, illness was mild and associated with limited temperature elevation and nonsp ... | 1999 | 10476753 |
| chronic chlamydia pneumoniae infection: a treatable cause of chronic fatigue syndrome. | 1999 | 10476765 | |
| [chlamydia pneumoniae--a suspected pathogenetic factor in coronary arteriosclerosis]. | 1999 | 10478365 | |
| infection with chlamydia pneumoniae and atherosclerosis: a review. | there are numerous studies that were able to find c. pneumoniae infections as a contributing factor in atherosclerosis pathogenesis. positive serology for c. pneumoniae was found in most studies in patients with atherosclerosis (igg, iga, igm). most studies were able to correlate an elevated iga antibody titer rather than the igg titer to the risk for atherosclerosis. c. pneumoniae and its components (dna, antigens) were detected in atherosclerotic plaques using immunohistochemistry, pcr, electr ... | 1999 | 10478518 |
| [chlamydia pneumoniae and arteriosclerosis: an innocent onlooker?]. | 1999 | 10481330 | |
| [detection of anti-chlamydia trachomatis antibody by means of enzyme immunoassay using synthetic peptide antigen]. | newly developed diagnostic kits for the detection of anti-chlamydia trachomatis, peptide-chlamvdia (loy: meiji milk products co., ltd., tokyo; for igg and iga), were evaluated using the microimmunofluorescence assay (mif) as the gold standard. these results were also compared to results of testing by sero-ipalisa and immunoblot (i-b). detection by loy in based on enzyme immunoassay with synthetic peptides as the antigen. thirty serum samples from pediatric patients and 130 serum samples from gyn ... | 1999 | 10481397 |
| the presence of chlamydia pneumoniae in atherosclerotic plaques--a report of three cases of ischaemic heart disease. | the report presents three cases of ischaemic heart disease in which chlamydia pneumoniae infections were detected first serologically, later the bacteria were shown in atherosclerotic plaques with electron microscopy, and finally c. pneumoniae strains were isolated from the tissues. | 1999 | 10481533 |
| chlamydia pneumoniae is an important cause of community-acquired pneumonia in school-aged children: serological results of a prospective, population-based study. | the aetiology of community-acquired pneumonia in childhood was studied in the total population of 8851 children in the area of 4 municipalities in eastern finland. all cases of community-acquired pneumonia (n = 201) were registered during a surveillance period of 12 months between september 1, 1981 and august 31, 1982. the diagnosis of pneumonia was verified radiologically in all identified cases. the diagnosis of chlamydial infection was based on an antibody response measured by complement fixa ... | 1999 | 10482053 |
| no serological evidence of association between chlamydia pneumonia infection and acute coronary heart disease. | today's medical literature shows more and more evidence that chlamydia pneumoniae plays a role in coronary atherosclerotic disease. this cross-sectional study examines the serostatus for c. pneumoniae of patients with an acute cardiovascular event. a total of 58 patients with acute myocardial infarction or with proven unstable angina (occlusion > or = 70% of at least 1 vessel at coronary angiography) ('patients') were compared with 58 age- and sex-matched patients without a cardiovascular event ... | 1999 | 10482054 |
| bordetella pertussis, bordetella parapertussis, mycoplasma pneumoniae, chlamydia pneumoniae and persistent cough in children. | material collected during a prospective pertussis vaccine trial in 1992-95 was examined for bordetella pertussis (culture and serology), bordetella parapertussis (culture), mycoplasma pneumoniae and chlamydia pneumoniae (pcr). from 64% (99/155) of episodes with cough for less than 100 d, 115 aetiological agents were identified in one southern and one northern subset of dt-recipients. the most common single agent was b. pertussis, representing 56%(64/115), with a median cough period of 51 d, foll ... | 1999 | 10482058 |
| chlamydia pneumoniae as a trigger of reactive arthritis. | 1999 | 10482071 | |
| lack of association of restenosis following coronary angioplasty with elevated c-reactive protein levels or seropositivity to chlamydia pneumoniae. | seventy-five consecutive patients undergoing directional coronary atherectomy were evaluated by measuring anti-chlamydia immunoglobulin g and anticytomegalovirus immunoglobulin g antibodies, and serum levels of c-reactive proteins (before atherectomy). the results showed that although both chlamydia infection and elevated c-reactive protein levels are associated with coronary artery disease and coronary artery disease events, neither of these appears to play a role in the development of restenos ... | 1999 | 10482163 |
| [chlamydia pneumoniae infection and atherosclerosis]. | 1999 | 10483155 | |
| chlamydia pneumoniae in redo and first-time coronary artery bypass graft surgery. | 1999 | 10483982 | |
| chlamydia pneumoniae and anti-infective therapy: their role in the pathogenesis and treatment of coronary artery disease. | cardiovascular disease remains the most common cause of death in the united states; however, conventional cardiovascular risk factors fail to explain completely the pathogenesis of atherosclerosis and coronary artery disease. there has been recent interest in the association between chlamydia pneumoniae and the risk of development or progression of atherosclerotic disease. this association has become evident through serologic, pathologic, and animal-based models and, more recently, through limit ... | 1999 | 10485501 |
| does chlamydia pneumoniae cause atherosclerosis? | 1999 | 10487585 | |
| optimizing culture of chlamydia pneumoniae by using multiple centrifugations. | three methods for the recovery of chlamydia pneumoniae from spiked nasopharyngeal and blood specimens, including extended culture and additional centrifugations, were compared. additional centrifugations and a 7-day culture time resulted in a 500- to 5, 000-fold increase in the number of detectable inclusion-forming units. | 1999 | 10488218 |
| [infection hypothesis for the pathogenesis of atherosclerosis--caused by chlamydia pneumoniae?]. | possible causal relationship between development of atherosclerosis and chlamydia pneumoniae infection is discussed. if the hypothesis is verified, antibiotics will play important role in the treatment of this artery disease. | 1999 | 10494168 |
| serological investigation of chlamydia trachomatis heat shock protein 10. | the humoral immune response to chlamydia trachomatis 10-kda heat shock protein (chsp10) in populations of russian and french origin was studied by using a recombinant chsp10 enzyme-linked immunosorbent assay. a physiological but not a serological correlation of chsp10 exposure with chsp60 exposure was observed in the russian population. in the french population studied, there was a significant association between detection of anti-r-chsp10 immunoglobulin g (igg) antibodies and chronic genital tr ... | 1999 | 10496901 |
| helicobacter pylori and chronic bronchitis. | chronic infections such as those caused by helicobacter pylori, chlamydia pneumoniae, and cytomegalovirus have been epidemiologically related to coronary heart disease (chd). other studies place h. pylori in relation to other extradigestive diseases. we carried out an epidemiologic pilot study to evaluate the prevalence of h. pylori in patients with chronic bronchitis, a respiratory disease characterized by persistent chronic inflammation, in comparison with a matched control group. | 1999 | 10499486 |
| chlamydia pneumoniae infection of vascular smooth muscle and endothelial cells activates nf-kappab and induces tissue factor and pai-1 expression: a potential link to accelerated arteriosclerosis. | recent reports link c. pneumoniae infection of arteriosclerotic lesions to the precipitation of acute coronary syndromes, which also feature tissue factor and plasminogen activator inhibitor 1 (pai-1) overexpression. we investigated whether or not c. pneumoniae can induce thrombogenicity by upregulation of procoagulant proteins. | 1999 | 10500035 |
| safety and effect on anti-chlamydia pneumoniae antibody titres of a 1 month course of daily azithromycin in adults with coronary artery disease. | a pilot study of azithromycin treatment following percutaneous coronary revascularization procedures was performed to assess safety and the effect of azithromycin treatment on anti-chlamydia pneumoniae antibody titres. patients were randomized to a 1 month course of azithromycin (total dose of 8.0 g) or placebo. safety and compliance were assessed at 2 and 4 weeks and serological testing was performed on samples obtained at enrolment and at 6 months post-enrolment. azithromycin was well tolerate ... | 1999 | 10511413 |
| iron and the role of chlamydia pneumoniae in heart disease. | 1999 | 10511533 | |
| the prevalence of chlamydia pneumoniae antibodies in thai patients with coronary artery disease. | blood samples were obtained from 243 consecutive coronary artery disease (cad) patients (177 male, 66 female) aged 35-78 years (mean, 61 years) admitted for coronary angiography because of suspected coronary heart disease, and from 115 blood donors (91 male, 24 female) aged 25-60 years (mean, 47 years). of the 243 cad patients, 179 (74%) were positive by an elisa method for chlamydia pneumoniae antibodies igg and 132 (54%) were positive for c. pneumoniae iga. among the 115 blood donors, 80 (70%) ... | 1999 | 10511787 |
| chlamydia pneumoniae antibodies and high lipoprotein(a) levels do not predict ischemic cerebral infarctions. results from a nested case-control study in northern sweden. | an association between high lipoprotein(a) [lp(a)] levels and positive chlamydia pneumoniae igg titers in coronary artery disease has been described. the possibility of predicting ischemic stroke by measurements of plasma lp(a) and c pneumoniae antibodies was investigated. | 1999 | 10512900 |
| lack of association between seropositivity to chlamydia pneumoniae and carotid atherosclerosis. | since the chlamydia pneumoniae (c. pneumoniae)-specific antibody was shown to be associated with acute myocardial infarction and chronic coronary heart disease, the role of c. pneumoniae in the etiology of cardiovascular disease has been studied by a number of groups. we investigated the association between the c. pneumoniae-specific antibody, measured by microimmunofluorescence, risk factors for cardiovascular disease, and atherosclerosis in a randomly selected urban population. overall, immuno ... | 1999 | 10513782 |
| lower prevalence of chlamydia pneumoniae dna compared with chlamydia trachomatis dna in synovial tissue of arthritis patients. | to assess the presence of chlamydia pneumoniae dna in the joints of patients with reactive arthritis (rea) and other arthritides. | 1999 | 10513803 |
| chlamydia pneumoniae may be associated with lung cancer. preliminary report on a seroepidemiological study. | material from 117 consecutive patients with lung cancer was investigated with respect to serological markers for chronic chlamydia pneumoniae infection. specific c. pneumoniae iga antibodies were found significantly more often in patients with lung cancer than in control groups with coronary heart disease and in healthy controls, even after adjustment for smoking. the results suggest that chronic c. pneumoniae infection is common in patients with lung cancer. | 1999 | 10519317 |
| demonstration of chlamydia pneumoniae in tissue by immunohistochemistry. | chronic chlamydia pneumoniae infection may be difficult to diagnose using routine methods such as culture, antigen detection, serology and polymerase chain reaction (pcr). we describe a method for the immunohistochemical staining of tissue biopsies using a c. pneumoniae-specific monoclonal antibody and a streptavidin/biotin technique. this method provides specific identification of the organism and reveals its actual location in tissues which may or may not be inflamed. host cells containing c. ... | 1999 | 10519326 |
| quantitation of bacterial adherence by image analysis. | in studies of the adherence of pathogenic bacteria to host eukaryotic cells in vitro, the counting of the bacteria is often challenging, especially if many experiments are involved. we developed a method to use digital imaging and computer-aided recognition for the quantitation of bacteria attached to cultured cells. we employed an immunocytochemical method to stain the bacteria and leave the hosts cells relatively unstained. we describe this method for use with five species of bacteria, strepto ... | 1999 | 10520581 |
| baseline igg antibody titers to chlamydia pneumoniae, helicobacter pylori, herpes simplex virus, and cytomegalovirus and the risk for cardiovascular disease in women. | results of cross-sectional and retrospective studies have suggested that chronic infection may be a risk factor for cardiovascular disease. however, prospective data evaluating the relation between baseline antibody titers against various plausible agents and risk for cardiovascular disease are sparse, particularly among women. | 1999 | 10523217 |
| chlamydia pneumoniae infection in children with persistent cough. | 1999 | 10523255 | |
| [infections and cardiovascular disease]. | epidemiological studies indicate that respiratory tract and dental infections increase the risk of atherosclerotic cardiovascular disease. several microorganisms have been claimed as clinically important, especially chlamydia pneumoniae (cp) and cytomegalovirus (cmv), cp is frequently isolated from atherosclerotic plaques, and treatment with macrolide antibiotics may have a beneficial effect on the course of ischaemic heart disease. cmv seems to play a role in the development of coronary stenosi ... | 1999 | 10523948 |
| [chlamydia pneumoniae and atherosclerosis--the hen, the egg or five feathers?]. | 1999 | 10523951 | |
| polymerase chain reaction assay for detecting chlamydia pneumoniae in middle ear fluid of children with otitis media with effusion. | 1999 | 10530596 | |
| a multicenter study of grepafloxacin and clarithromycin in the treatment of patients with community-acquired pneumonia. | to compare the efficacies of 10-day regimens of grepafloxacin (gfx) (raxar or vaxar; glaxo wellcome; greenford, uk), 600 qd, and clarithromycin (cla) (klacid, biaxin, or klaracid; abbott laboratories; chicago, il), 500 mg bid, in patients with community-acquired pneumonia (cap), on the basis of clinical response, including radiographic evidence, and bacteriologic efficacy. | 1999 | 10531162 |
| de novo induction of atherosclerosis by chlamydia pneumoniae in a rabbit model. | chlamydia pneumoniae, a bacterial respiratory tract pathogen, has been associated with atherosclerosis in humans. c. pneumoniae infection of the respiratory tracts of rabbits fed a noncholesterol diet induced changes of atherosclerosis of the aorta in 6 (26.1%) of 23 animals after a single inoculum at 3 months. multiple inocula given three times within 6 weeks resulted in grade iii atherosclerosis in 8 (34.8%) of 23 rabbits, with an additional 5 (21. 7%) showing increased myxoid changes in the i ... | 1999 | 10531266 |
| chlamydia trachomatis (mouse pneumonitis strain) induces cardiovascular pathology following respiratory tract infection. | chlamydia, especially chlamydia pneumoniae, infection is closely associated with human cardiovascular diseases. thus far, however, few experimental studies have been carried out to investigate whether natural c. trachomatis infection can induce cardiovascular pathological changes. in this article, we report that pulmonary infection with c. trachomatis mouse pneumonitis strain (mopn) can induce myocardial and perivascular inflammation and fibrosis in c57bl/6 mice. the pulmonary mopn infection app ... | 1999 | 10531278 |
| [clinical analysis of pneumonia in the elderly in a community hospital--comparison of community-acquired pneumonia and nosocomial pneumonia]. | we experienced 530 elderly cases with pneumonia among 930 patients with pneumonia in kawasaki medical school kawasaki hospital between april 1986 and september 1998. clinical analysis of all these patients and a comparison of one group consisting of 418 patients with community-acquired pneumonia and another group composed of 112 patients with nosocomial pneumonia were performed. in all of the elderly patients with pneumonia, respiratory symptoms and inflammatory findings were less frequent, but ... | 1999 | 10535263 |