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daily supplementation with grandfusion(®) improves memory and learning in aged rats.studies have shown that supplementation with extracts from various sources, including fruits and vegetables reverse the age-related changes in movement and cognition. we hypothesized that these beneficial effects result from the presence of anti-oxidants and anti-inflammatory compounds in the fruits and vegetables that contribute to reduced oxidative stress, inflammation and cell death while potentially enhancing neurogenesis. the present study was performed to determine the impact of supplement ...201728351996
history of childhood maltreatment and symptoms of anxiety and depression in women with chronic pelvic pain.to determine the prevalence of physical, sexual and emotional abuse and physical and emotional neglect suffered by women with chronic pelvic pain (cpp) during childhood and whether these occurrences are associated with symptoms of pain, anxiety and depression.201728351202
the role of the away rotation in otolaryngology residency.objective to determine the availability and purpose of away rotations during otolaryngology residency. study design cross-sectional survey. setting otolaryngology residency programs. subjects and methods an anonymous web-based survey was sent to 98 allopathic otolaryngology training program directors, of which 38 programs responded. fisher exact tests and nonparametric correlations were used to determine statistically significant differences among various strata of programs. a p value of <.05 wa ...201728349746
peripheral fundus findings in x-linked retinoschisis.vitreous haemorrhage (vh) and retinal detachment (rd) cause a precipitous decline in vision in a subset of patients with x-linked retinoschisis (xlrs), an otherwise a slowly progressive condition. this study aims to report the frequency of macular and peripheral retinal findings in a large cohort of patients with xlrs and to determine whether peripheral retinal findings are associated with vh and rd.201728348004
the effect of nefopam on lactation after caesarean section: a single-blind randomised trial.nefopam is a centrally acting analgesic which has a theoretical risk of stopping lactation due to its anticholinergic and dopaminergic effects. the aim of this study was to evaluate the effect of nefopam on lactation and to investigate potential adverse effects on newborns.201728347572
magnetic resonance imaging tumor regression shrinkage patterns after neoadjuvant chemotherapy in patients with locally advanced breast cancer: correlation with tumor biological subtypes and pathological response after therapy.the objective of this study is to analyze magnetic resonance imaging shrinkage pattern of tumor regression after neoadjuvant chemotherapy and to evaluate its relationship with biological subtypes and pathological response. we reviewed the magnetic resonance imaging studies of 51 patients with single mass-enhancing lesions (performed at time 0 and at the ii and last cycles of neoadjuvant chemotherapy). tumors were classified as luminal a, luminal b, her2+, and triple negative based on biological ...201728347225
high-resolution isotopic monitoring of cave air co2.co2 is the main driver of many chemical processes in cave environments. understanding co2 fluxes in a given cave system through monitoring campaigns has become a standard procedure in a wide variety of fields such as paleoclimatology or show cave management. however, conventional methods lack the resolution of isotopic data to capture many transient processes occurring in caves.201728346708
patient comprehension of carpal tunnel surgery: an investigation of health literacy.background: health literacy is the ability of a patient to understand their medical condition. the purpose of this investigation is to determine whether patients are able to obtain an elementary understanding of the fundamental principles of carpal tunnel release and the postoperative instructions after going through the process of informed consent and being provided an additional standardized postoperative instruction document. our hypothesis is that patients will lack an understanding of these ...201728344530
physicochemical attributes and dissolution testing of ophthalmic ointments.the investigation of semisolid ophthalmic ointments is challenging due to their complex physicochemical properties and the unique anatomy of the human eye. using lotemax(®) as a model ophthalmic ointment, three different manufacturing processes and two excipient sources (fisher(®) (owp) and fougera(®) (nwp)) were used to prepare loteprednol etabonate ointments that were qualitatively and quantitatively the same across the manufactured formulations. physicochemical properties including drug conte ...201728344172
staphylococcus aureus nasal carriage in health care workers: first report from a major public hospital in argentina.staphylococcus aureus causes numerous mild to severe infections in humans, both in health facilities and in the community. patients and health care workers (hcws) may disseminate strains during regular medical examinations or hospitalization. the aim of this study was to determine the nasal carriage rate of methicillin-susceptible and methicillin-resistant s. aureus among health care workers at hospital provincial del centenario, a public general hospital in rosario, argentina. a transversal stu ...201728343857
effect of probiotic on innate inflammatory response and viral shedding in experimental rhinovirus infection - a randomised controlled trial.ingestion of probiotics appears to have modest effects on the incidence of viral respiratory infection. the mechanism of these effects is not clear; however, there is evidence from animal models that the probiotic may have an effect on innate immune responses to pathogens. the purpose of this randomised, placebo-controlled study was to determine the effect of administration of bifidobacterium animalis subspecies lactis bl-04 on innate and adaptive host responses to experimental rhinovirus challe ...201728343401
cervical disc arthroplasty: do conflicts of interest influence the outcome of clinical studies?cervical disc arthroplasty (cda) is an emerging technique for the treatment of cervical degenerative disease. multiple studies have investigated the outcomes of cda, particularly in comparison with cervical arthrodesis techniques such as anterior cervical discectomy and fusion (acdf). as many entities have financial interests in cda implants, it is imperative to consider the influence of conflicts of interest on the results of studies investigating the efficacy of cda.201728343045
comparison of two massively parallel sequencing platforms using 83 single nucleotide polymorphisms for human identification.the potential of massively parallel sequencing (mps) technology to vastly expand the capabilities of human identification led to the emergence of different mps platforms that use forensically relevant genetic markers. two of the mps platforms that are currently available are the miseq(®) fgx™ forensic genomics system (illumina) and the hid-ion personal genome machine (pgm)™ (thermo fisher scientific). these are coupled with the forenseq™ dna signature prep kit (illumina) and the hid-ion ampliseq ...201728341840
gallbladder toxicity and high-dose ablative-intent radiation for liver tumors: should we constrain the dose?little is known about the risk of gallbladder toxicity from hypofractionated (hfxrt) and stereotactic body radiation therapy (sbrt). we report on gallbladder toxicity and attribution to treatment in a prospective series of patients with primary and metastatic liver tumors receiving ablative-intent hfxrt and sbrt with protons.201728341320
a non-zero variance of tajima's estimator for two sequences even for infinitely many unlinked loci.the population-scaled mutation rate, θ, is informative on the effective population size and is thus widely used in population genetics. we show that for two sequences and n unlinked loci, the variance of tajima's estimator (θˆ), which is the average number of pairwise differences, does not vanish even as n→∞. the non-zero variance of θˆ results from a (weak) correlation between coalescence times even at unlinked loci, which, in turn, is due to the underlying fixed pedigree shared by gene genealo ...201728341209
factors associated with intramammary infection in dairy cows caused by coagulase-negative staphylococci, staphylococcus aureus, streptococcus uberis, streptococcus dysgalactiae, corynebacterium bovis, or escherichia coli.the aim of this study was to determine risk factors for bovine intramammary infection (imi) associated with the most common bacterial species in finland. large databases of the finnish milk-recording system and results of microbiological analyses of mastitic milk samples from valio ltd. (helsinki, finland) were analyzed. the study group comprised 29,969 cows with imi from 4,173 dairy herds. a cow with a quarter milk sample in which dna of target species was detected in the pathoproof mastitis pc ...201728341052
ultimate precision of adaptive noise estimation.we consider the estimation of noise parameters in a quantum channel, assuming the most general strategy allowed by quantum mechanics. this is based on the exploitation of unlimited entanglement and arbitrary quantum operations, so that the channel inputs may be interactively updated. in this general scenario, we draw a novel connection between quantum metrology and teleportation. in fact, for any teleportation-covariant channel (e.g., pauli, erasure, or gaussian channel), we find that adaptive n ...201728339261
identification of the eucalyptus grandis chitinase gene family and expression characterization under different biotic stress challenges.eucalyptus grandis (w. hill ex maiden) is an australian myrtaceae tree grown for timber in many parts of the world and for which the annotated genome sequence is available. known to be susceptible to a number of pests and diseases, e. grandis is a useful study organism for investigating defense responses in woody plants. chitinases are widespread in plants and cleave glycosidic bonds of chitin, the major structural component of fungal cell walls and arthropod exoskeletons. they are encoded by an ...201728338992
[value of tumor deposits in staging and prognostic evaluation in gastric cancer patients].to analyze relationships between the tumor deposits (td) and clinicopathologic features of gastric cancer and investigate the value of td in staging and prognosis in gastric cancer patients.201728338160
comparison of amikacin pharmacokinetics in neonates following implementation of a new dosage protocol.the primary aim was to compare attainment of goal serum amikacin concentrations using two dosage regimens in patients admitted to a neonatal intensive care unit. secondary objectives included comparison of percentages of supratherapeutic trough concentrations, and subtherapeutic and supratherapeutic peak concentrations.201728337079
an updated review of ciguatera fish poisoning: clinical, epidemiological, environmental, and public health management.ciguatera fish poisoning (cfp) is the most frequently reported seafood-toxin illness in the world. it causes substantial human health, social, and economic impacts. the illness produces a complex array of gastrointestinal, neurological and neuropsychological, and cardiovascular symptoms, which may last days, weeks, or months. this paper is a general review of cfp including the human health effects of exposure to ciguatoxins (ctxs), diagnosis, human pathophysiology of cfp, treatment, detection of ...201728335428
primary versus preoperative radiation for locally advanced vulvar cancer.the objective of this study was to evaluate patterns of care and the survival impact of primary radiation and preoperative radiation therapy with surgery in women with locally advanced vulvar cancer using a large national cohort.201728333840
ultrasound image despeckling using stochastic distance-based bm3d.ultrasound image despeckling is an important research field, since it can improve the interpretability of one of the main categories of medical imaging. many techniques have been tried over the years for ultrasound despeckling, and more recently, a great deal of attention has been focused on patch-based methods, such as non-local means and block-matching collaborative filtering (bm3d). a common idea in these recent methods is the measure of distance between patches, originally proposed as the eu ...201728333627
understanding faculty and trainee needs related to scholarly activity in a large, nonuniversity graduate medical education program.graduate medical education (gme) programs must develop curriculum to ensure scholarly activity among trainees and faculty to meet accreditation requirements and to support evidence-based medicine.201728333607
patterns of chemotherapy-induced toxicities and outcome in children and adolescents with metastatic rhabdomyosarcoma: a report from the children's oncology group.we sought to determine whether adolescents with metastatic alveolar rhabdomyosarcoma (arms) or embryonal rms (erms) had a different event-free survival (efs) compared with younger patients, and to identify treatment-related factors (adverse events, aes) that may be associated with differences in outcome.201728333415
optimizing the number of embryos to transfer on day 5: two should be the limit.to define the appropriate number of embryos to be transferred at day 5.201728333024
work related injury among saudi star agro industry workers in gambella region, ethiopia; a cross-sectional study.work injury is an important cause of morbidity and mortality, much of these work injuries burden can be found in industry required heavy manual work such as, agriculture and fishers. hence; agriculture is consistently cited as one of the most hazardous industry in the world. the objective of this study isto assess the magnitude and associated factors of work related injury among saudi star agro industry workers in gambella region, south west ethiopia.201728331533
germline genetic biomarkers of sunitinib efficacy in advanced renal cell carcinoma: results from the renal effect trial.sunitinib, the vascular endothelial growth factor pathway inhibitor, is an established standard-of-care for advanced renal cell carcinoma (rcc). this study aimed to assess correlations between candidate germline single nucleotide polymorphisms (snps) and sunitinib efficacy in patients from the renal effect trial (nct00267748), a randomized phase ii study in patients with metastatic rcc comparing the 4-weeks-on/2-weeks-off schedule and a continuous daily dosing schedule.201728330808
can mthfr c677t and a1298c polymorphisms alter the risk and severity of sporadic breast cancer in brazilian women?polymorphisms in the methylenetetrahydrofolate reductase gene (mthfr) modify the risk and severity of sporadic breast cancer (bc). in this context, the mthfr c677t and a1298c polymorphisms have been associated with risk and severity of sporadic bc.201728330681
[an investigation on immunological effect of hepatitis b vaccine amongst adult population in high-labor-export rural regions, under 4 different strategies].objective: to grope for an ideal immune strategy in grown-ups via comparison of immunological effects under 4 different vaccination schemes. methods: study population was selected by stratified random cluster sampling. a total of 4 different vaccination proposals, including strategy a (3 doses, 10 μg, administrated repeatedly into the unilateral deltoid muscle at 0-1-6 months), strategy b (2 doses, 20 μg, administrated into the bilateral deltoid muscles simultaneously), strategy c (3 doses, 10 μ ...201728329932
public views on pulse oximetry screening for critical congenital heart disease.to understand public views on pulse oximetry screening for critical congenital heart disease.201728329450
epidermal growth factor receptor mutations are linked to skip n2 lymph node metastasis in resected non-small-cell lung cancer adenocarcinomas.the impact of skip n2 metastases (i.e. n2 lymph node metastases without n1) on survival in surgically resected non-small lung cancer remains an intriguing and rarely investigated topic. the goal of our study was to elucidate (i) skip n2 influence on overall survival (os) and time to recurrence (ttr) in patients with resected lung adenocarcinoma and (ii) its link with epidermal growth factor receptor ( egfr ) and v-ki-ras2 kirsten rat sarcoma viral oncogene homolog ( kras ) mutations.201728329143
vertebrobasilar system computed tomographic angiography in central vertigo.the incidence of vertigo in the population is 20% to 30% and one-fourth of the cases are related to central causes. the aim of this study was to evaluate computed tomography angiography (cta) findings of the vertebrobasilar system in central vertigo without stroke.cta and magnetic resonance images of patients with vertigo were retrospectively evaluated. one hundred twenty-nine patients suspected of having central vertigo according to history, physical examination, and otological and neurological ...201728328808
a confident information first principle for parameter reduction and model selection of boltzmann machines.typical dimensionality reduction (dr) methods are data-oriented, focusing on directly reducing the number of random variables (or features) while retaining the maximal variations in the high-dimensional data. targeting unsupervised situations, this paper aims to address the problem from a novel perspective and considers model-oriented dr in parameter spaces of binary multivariate distributions. specifically, we propose a general parameter reduction criterion, called confident-information-first ( ...201728328513
inadequate antioxidative responses in kidneys of brain-dead rats.brain death (bd)-related lipid peroxidation, measured as serum malondialdehyde (mda) levels, correlates with delayed graft function in renal transplant recipients. how bd affects lipid peroxidation is not known. the extent of bd-induced organ damage is influenced by the speed at which intracranial pressure increases. to determine possible underlying causes of lipid peroxidation, we investigated the renal redox balance by assessing oxidative and antioxidative processes in kidneys of brain-dead ra ...201728323775
reproductive tract infections: attitude and barriers among marginalized fisher women in kerala, south india.reproductive tract infections (rtis) are the cause of severe gynecological and maternal morbidity in india. in marginalized communities, women persevere quietly when faced with a culturally sensitive health issue such as an rti. to hypothesize on the differential health behavior and low levels of reported incidents among women living in marginalized communities, we undertake an exploratory study in a coastal fishermen community in south india. we identify barriers influencing decisions to seek c ...201728323558
prognostic impact of gata binding protein-3 expression in primary lung adenocarcinoma.gata binding protein-3 (gata3) is a transcription factor that regulates cell differentiation and maintenance in some types of normal cells. this study aimed to investigate the association between gata3 expression and primary lung adenocarcinoma and to clarify the clinical significance of gata3 expression in lung adenocarcinoma. immunohistochemical gata3 expression was evaluated using completely resected lung adenocarcinoma samples from 95 cases. gata3 immunohistochemical staining was performed a ...201728322854
cytotoxicity, biocompatibility, and biomineralization of the new high-plasticity mta material.mineral trioxide aggregate (mta) has excellent biological properties, but its handling properties have been criticized for both proroot mta (tulsa dental products, tulsa, ok) and white mta-angelus (mta-ang; angelus indústria de produtos odontológicos s/a, londrina, pr, brazil). angelus mta hp (high plasticity) (angelus indústria de produtos odontológicos s/a) has been introduced recently. considering the importance of biological properties of materials that will be in contact with the tissues, t ...201728320539
comparison of initial vasopressors used for delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.the main reason for morbidity after aneurysmal subarachnoid hemorrhage (asah) is delayed cerebral ischemia (dci). the mainstay of medical therapy for treating dci is induced hypertension with vasopressors to restore cerebral perfusion. both phenylephrine (pe) and norepinephrine (ne) are commonly used for induced hypertension, but the impact of the initial choice of vasopressor on the efficacy, adverse effects, or outcome after hemodynamic therapy for dci is unknown.201728319954
microcystic, elongated, and fragmented pattern invasion in ovarian endometrioid carcinoma: immunohistochemical profile and prognostic implications.microcystic, elongated, and fragmented (melf) pattern invasion is a poor prognostic indicator in uterine endometrioid carcinoma, but its existence, biology, and prognostic value have not been described in ovarian endometrioid carcinoma. we evaluated cases of ovarian endometrioid carcinoma without synchronous uterine endometrioid carcinoma for melf and other histologic features. to evaluate tumor biology, we assessed an immunohistochemical profile, including mlh1, pms2, msh2, msh6, β-catenin, e-c ...201728319570
does thromboprophylaxis cause bleeding after laparoscopic cholecystectomy?this study reports the results of a single center experience on the use of pharmacological venous thromboembolism (vte) prophylaxis in laparoscopic cholecystectomy patients.201728319411
a comprehensive analysis of programmed cell death ligand-1 expression with the clone sp142 antibody in non-small-cell lung cancer patients.programmed cell death-1 (pd-1) and programmed cell death ligand-1 (pd-l1) have been identified as novel targets for immunotherapy, with anti-pd-1 therapy currently the standard treatment for non-small-cell lung cancer (nsclc) patients after the failure of first-line chemotherapy treatment. the recent phase ii poplar and phase iii oak studies showed that atezolizumab, a representative pd-l1 inhibitor, exhibited a survival benefit compared with standard therapy in patients with nsclc.201728318951
late-life depression, hippocampal volumes, and hypothalamic-pituitary-adrenal axis regulation: a systematic review and meta-analysis.we systematically reviewed and meta-analyzed the association of late-life depression (lld) with hippocampal volume (hcv) and total brain volume (tbv), and of cortisol levels with hcv, including subgroup analyses of depression characteristics and methodological aspects.201728318491
familial cerebral cavernous malformations are associated with adrenal calcifications on ct scans: an imaging biomarker for a hereditary cerebrovascular condition.purpose to determine if adrenal calcifications seen at computed tomography (ct) are associated with familial cerebral cavernous malformations (fccms) in carriers of the ccm1 common hispanic mutation. materials and methods this study was approved by the institutional review board. the authors retrospectively reviewed abdominal ct scans in 38 patients with fccm, 38 unaffected age- and sex-matched control subjects, and 13 patients with sporadic, nonfamilial cerebral cavernous malformation (ccm). th ...201728318403
one-year survival is not affected by gastrointestinal bleeding after percutaneous coronary interventions.percutaneous coronary intervention (pci) has been the main therapy in acute coronary syndromes, and early antithrombotic agents as well as 1-year dual antiplatelet therapy are required for adjuvant therapy. however, the development of post-pci gastrointestinal (gi) bleeding may increase all-cause mortality. we compared the characteristics and outcomes of patients with gi bleeding within 1 year after pci to those who did not develop bleeding.201728317626
chlamydia trachomatis and hpv co-infections in hiv negative men from a multi-ethnic area of northern italy at high prevalence of cervical malignancies.chlamydia trachomatis and hpv coinfections in the male population are often a disregarded issue. we performed a study to evaluate the prevalence of such infections in heterosexual hiv negative men from a northern italy multi-ethnic area at high prevalence for cervical malignancies. urethral swabs (us) or first-voided urine were evaluated retrospectively from 1317 patients attending sexually transmitted infections (sti) clinic and from 3388 outpatients attending private clinics. informations abou ...201728316071
physician-scientists in obstetrics and gynecology: predictors of success in obtaining independent research funding.obstetrics and gynecology departments receive the smallest amount of national institutes of health research funding and have significantly lower application success rates compared to pediatric, internal medicine, and surgery departments. the development of mentored early career development training grants (k awards) has been one strategy implemented by the national institutes of health to help aspiring physician-scientists establish independent research careers.201728315665
estimation of some population parameters of drosophila limbata v. roser in a greenhouse.size and survival rate of a population of drosophila limbata in a cucumber greenhouse in the vicinity of groningen, the netherlands, were estimated twice in the summer of 1975 by mark-release-recapture experiments, using the fisher-ford model. the second time, an independent check was carried out by directly estimating the number of emergences. at the end of june, estimated population size was about 13,600, with a survival rate per day of 53.4%, at the end of july population size was estimated a ...197928308858
endoscope or microscope-guided pediatric tympanoplasty? comparison of grafting technique and outcome.to review experience from the introduction of totally endoscopic ear surgery (tees) to a pediatric tympanoplasty practice to identify factors influencing technique selection and successful outcome.201728304079
enhancing brain lesions during acute optic neuritis and/or longitudinally extensive transverse myelitis may portend a higher relapse rate in neuromyelitis optica spectrum disorders.neuromyelitis optica spectrum disorders are inflammatory demyelinating disorders with optic neuritis and/or longitudinally extensive transverse myelitis episodes. we now know that neuromyelitis optica spectrum disorders are associated with antibodies to aquaporin-4, which are highly concentrated on astrocytic end-feet at the blood-brain barrier. immune-mediated disruption of the blood-brain barrier may manifest as contrast enhancement on brain mr imaging. we aimed to delineate the extent and fre ...201728302609
classification and adaptive behavior prediction of children with autism spectrum disorder based upon multivariate data analysis of markers of oxidative stress and dna methylation.the number of diagnosed cases of autism spectrum disorders (asd) has increased dramatically over the last four decades; however, there is still considerable debate regarding the underlying pathophysiology of asd. this lack of biological knowledge restricts diagnoses to be made based on behavioral observations and psychometric tools. however, physiological measurements should support these behavioral diagnoses in the future in order to enable earlier and more accurate diagnoses. stepping towards ...201728301476
role of addition of dexamethasone to lignocaine 2% with adrenaline in dental nerve blocks for third molar surgery: a prospective randomized control trial.dexamethasone has been frequently used in oral surgical procedure and accepted by oral and maxillofacial surgeon community worldwide. however, this is the first clinical trial that used dexamethasone as adjuvant with lignocaine in dental nerve block (dnb).201728299268
elongated styloid process evaluation on digital panoramic radiograph in a north italian population.the aim of this study is to evaluate the prevalence of elongated styloid process in digital panoramic radiographs in a north italian population in relation to age, gender and side.201728298982
attenuation of hemodynamic response to skull pin head holder insertion: intravenous clonidine versus intravenous lignocaine infusion.insertion of skull pin induces a significant increase in heart rate (hr), blood pressure (bp) and intracranial pressure. alpha 2 agonist clonidine and intravenous (i.v.) lignocaine are effective in attenuating stress response. local infiltration of pin site and scalp block with lignocaine are commonly used techniques for prevention of hemodynamic response to skull pin insertion. we compared the effectiveness of i.v. clonidine infusion and i.v. lignocaine infusion in suppressing the hemodynamic r ...201728298771
evaluation of sublingual microcirculation in a paediatric intensive care unit: prospective observational study about its feasibility and utility.evaluation of the microcirculation in critically ill patients is usually done by means of indirect parameters. the aim of our study was to evaluate the functional state of the microcirculation by direct visualization of sublingual microcirculation using sidestream dark field imaging, to determine the correlation between these findings and other parameters that are commonly used in the clinical practice and to assess the applicability of the systematic use of this technique in critically ill chil ...201728298202
accuracy of rate coding: when shorter time window and higher spontaneous activity help.it is widely accepted that neuronal firing rates contain a significant amount of information about the stimulus intensity. nevertheless, theoretical studies on the coding accuracy inferred from the exact spike counting distributions are rare. we present an analysis based on the number of observed spikes assuming the stochastic perfect integrate-and-fire model with a change point, representing the stimulus onset, for which we calculate the corresponding fisher information to investigate the accur ...201728297875
sternal development and variations and anomalies in patients with microtia: evaluation using 3-dimensional computed tomography.the objectives of this study were to evaluate sternal development and variations in patients with microtia and to identify the incidence of congenital sternal anomalies and then to investigate the interaction between microtia and sternal anomalies.201728296686
histomorphology and immunophenotype of eczematous skin lesions revisited-skin biopsies are not reliable in differentiating allergic contact dermatitis, irritant contact dermatitis, and atopic dermatitis.lesions of allergic contact dermatitis (acd), irritant contact dermatitis (icd), and atopic dermatitis (ad) share similar clinical features and thus, their diagnosis can be challenging. the aim of this study was to reassess histopathology and immunophenotyping properties to distinguish between acd, icd, and ad. charts of patients with eczema, who had undergone complete routine diagnostic workup (skin biopsies, patch tests, skin prick tests, and respectively or serum ige levels), were reviewed. t ...201728296664
comparison of readout-segmented and conventional single-shot for echo-planar diffusion-weighted imaging in the assessment of kidney interstitial fibrosis.to compare readout-segmented echo-planar imaging (epi) (resolve) to single-shot epi (ss-epi) diffusion-weighted imaging (dwi) for the assessment of renal interstitial fibrosis.201728295820
acoustic telemetry and fisheries management.this paper reviews the use of acoustic telemetry as a tool for addressing issues in fisheries management, and serves as the lead to the special feature issue of ecological applications titled acoustic telemetry and fisheries management. specifically, we provide an overview of the ways in which acoustic telemetry can be used to inform issues central to the ecology, conservation, and management of exploited and/or imperiled fish species. despite great strides in this area in recent years, there ar ...201728295789
anatomic reconstruction of the anterior cruciate ligament of the knee with or without reconstruction of the anterolateral ligament: a randomized clinical trial.rotational instability of the knee remains an issue after anterior cruciate ligament (acl) reconstruction. hypothesis/purpose: the purpose was to evaluate the subjective and objective outcomes of combined reconstruction of the acl and anterolateral ligament (all) of the knee. the hypothesis was that favorable outcomes can be achieved with this surgical procedure compared with isolated anatomic reconstruction of the acl.201728293966
reproductive biology of leptocybe invasa fisher & la salle (hymenoptera: eulophidae).leptocybe invasa fisher & la salle (hymenoptera: eulophidae) is an invasive pest in eucalyptus plantations around the world. the successful colonization of l. invasa is possibly related to its reproductive biology. the objective of this study was to examine the reproductive biology of l. invasa. in guangxi province, the sex ratio (proportion of female, 0.99) of l. invasa was female-dominant throughout the year based on natural and artificial infestation. this result was similar to the ratios obs ...201728293863
body image drawings dissociate ethnic differences and anorexia in adolescent girls.to distinguish between ethnic differences among segregated schoolgirls and restrictive anorexia nervosa using a simple culture-fair test of body image (bi) figure drawings.201728293285
[prevalence and factors associated with anemia in pregnant women attending the general hospital in douala].anemia is a public health problem, prevalent among children and women of childbearing age. our study aims to determine the prevalence and factors associated with anemia in pregnant women at douala general hospital.201628292095
after the recall: reexamining multiple magnet ingestion at a large pediatric hospital.to evaluate the effectiveness of a mandatory product recall on the frequency of multiple mini-magnet ingestion at a large tertiary pediatric hospital, and to examine the morbidity and mortality associated with these ingestions.201728291530
towards a chromatographic similarity index to establish localised quantitative structure-retention relationships for retention prediction. ii use of tanimoto similarity index in ion chromatography.quantitative structure-retention relationships (qsrr) are used to predict retention times of compounds based only on their chemical structures encoded by molecular descriptors. the main concern in qsrr modelling is to build models with high predictive power, allowing reliable retention prediction for the unknown compounds across the chromatographic space. with the aim of enhancing the prediction power of the models, in this work, our previously proposed qsrr modelling approach called "federation ...201728291517
significance of micrometastases in the calculation of the lymph node ratio for papillary thyroid cancer.the lymph node ratio (lnr) is an important prognostic factor in papillary thyroid carcinoma (ptc), but micrometastases in cervical lymph nodes (lns) are not of great clinical importance. in this study, we analyzed the accuracy of prediction of the prognosis depending on whether micrometastases were included in the number of metastatic lns when calculating lnr.201728289664
therapeutic effect of microcurrent therapy in children with in-toeing gait caused by increased femoral anteversion: a pilot study.to investigate the efficacy of portable microcurrent therapy device (pmtd) of the hip internal rotators in the treatment of in-toeing gait caused by increased femoral anteversion in children over 8 years of age.201728289642
daily users compared to less frequent users find vape as or more satisfying and less dangerous than cigarettes, and are likelier to use non-cig-alike vaping products.we assessed the roles of perceived satisfaction and perceived danger and vaping-product-type as correlates of more frequent use of vaping products. in a baseline assessment of a longitudinal study of us army reserve/national guard soldiers and their partners (new york state, usa, 2014-2016), participants were asked about current use of vaping products (e-cigarettes) and perceived satisfaction and danger in comparison to cigarettes as well as type of product used. fisher-exact tests and multiple ...201728289597
predicting life expectancy for pirfenidone in idiopathic pulmonary fibrosis.conducting an adequately powered survival study in idiopathic pulmonary fibrosis (ipf) is challenging due to the rare nature of the disease and the need for extended follow-up. consequently, registration trials of ipf treatments have not been designed to estimate long-term survival.201728287347
systematic review and network meta-analysis of idiopathic pulmonary fibrosis treatments.the antifibrotics pirfenidone and nintedanib are both approved for the treatment of idiopathic pulmonary fibrosis (ipf) by regulatory agencies and are recommended by health technology assessment bodies. other treatments such as n-acetylcysteine are used in clinical practice but have not received regulatory approval. no head-to-head trials have been conducted to directly compare the efficacy of these therapies in ipf.201728287346
[postoperative complications of labia minora reduction. comparative study between wedge and edge resection].labia minora reduction interventions rise in europe and in north america. several techniques are described. the objective of this study was to compare postoperative complications of the two most practiced interventions: wedge resection and edge resection.201728285885
screening obese adolescents for binge eating disorder in primary care: the adolescent binge eating scale.to investigate the performance of a simple and developmentally appropriate 10-item questionnaire (adolescent binge eating scale) for the prediction of binge eating disorder (bed) diagnosis in adolescents seen for obesity.201728285753
factors leading to oro-facial herpetic eruptions in patients undergoing surgery for vestibular schwannoma.to study factors influencing oro-facial herpetic eruptions (hes) in patients undergoing retromastoid suboccipital craniectomy for vestibular schwannomas (vs).201728284969
diplopia and ptosis after diarrhea - a diagnostic challenge.a woman developed transient diplopia and ptosis of the left eyelid after a campylobacter infection. the symptoms were interpreted as a miller fisher syndrome, a variant of guillain barré syndrome.201728284899
body mass index and the clinicopathological characteristics of clinically localized renal masses-an international retrospective review.to investigate the potential association between body mass index (bmi) and clinicopathological features of clinically localized renal masses.201728284892
use of gadolinium-based magnetic resonance imaging contrast agents and awareness of brain gadolinium deposition among pediatric providers in north america.numerous recent articles have reported brain gadolinium deposition when using linear but not macrocyclic gadolinium-based contrast agents (gbcas).201728283727
conformal bootstrap in mellin space.we propose a new approach towards analytically solving for the dynamical content of conformal field theories (cfts) using the bootstrap philosophy. this combines the original bootstrap idea of polyakov with the modern technology of the mellin representation of cft amplitudes. we employ exchange witten diagrams with built-in crossing symmetry as our basic building blocks rather than the conventional conformal blocks in a particular channel. demanding consistency with the operator product expansio ...201728282195
histomorphologic and ultrastructural recovery of myopathy in rats treated with low-level laser therapy.the purpose of the present work was to study the effect of low-level laser therapy (lllt): helium-neon (he-ne) and gallium arsenide (ga-as) laser on the histomorphology of muscle and mitochondria in experimental myopathy in rats. thirty suquía strain female rats were distributed in groups: (a) control (intact), (b) injured, (c) injured and treated with he-ne laser, (d) injured and treated with ga-as laser, (e) irradiated with he-ne laser on the non-injured muscle, and (f) irradiated with ga-as l ...201728280999
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 expression in brain arteriovenous malformations and its association with brain arteriovenous malformation size.brain arteriovenous malformations (bavm) are severe conditions that can cause severe neurologic deficits and mortality. the underlying cellular and molecular mechanisms associated with bavm growth and rupture remain unclear. the objective of this study was to explore the potential role of plod2 (procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2) in the pathophysiology of bavm.201728279775
end-of-life care and discussions in japanese geriatric health service facilities.geriatric health service facilities (ghsfs) play important roles as intermediate care facilities for elderly individuals temporarily when they need rehabilitation before returning home. however, the number of residents spending their end-of-life (eol) period in such facilities is increasing. to improve the quality of eol care, end-of-life discussions (eolds) are recommended by some guidelines and studies.201728279073
adult quality of life post cleft palate repair: a comparison of two techniques.in 1989, the cleft palate-craniofacial journal published the first randomized prospective cleft surgery study, comparing the kriens intravelar veloplasty (ivv) with a non-ivv 2-flap repair. results in that and follow-up publications yielded no difference between the 2 groups for need for secondary velopharyngeal management. the subjects have now reached adulthood. this study was designed to ask: is there any difference between the groups in the outcomes that multidisciplinary team care addresses ...201728277486
the impact of androgen receptor expression on endometrial carcinoma recurrence and survival.endometrial carcinomas (ecs) are the most common gynecologic cancers in the western world. the impact of androgen receptor (ar) on clinicopathologic parameters of ec is not well studied. the aim of our study is to assess the role of ar expression in ecs and correlate its expression with estrogen (er) and progesterone (pr). a retrospective review of 261 ec was conducted. h&e slides were reviewed and clinicopathologic parameters were analyzed. immunohistochemical stains for ar, er, and pr were per ...201728277313
optimal adaptive control for quantum metrology with time-dependent hamiltonians.quantum metrology has been studied for a wide range of systems with time-independent hamiltonians. for systems with time-dependent hamiltonians, however, due to the complexity of dynamics, little has been known about quantum metrology. here we investigate quantum metrology with time-dependent hamiltonians to bridge this gap. we obtain the optimal quantum fisher information for parameters in time-dependent hamiltonians, and show proper hamiltonian control is generally necessary to optimize the fi ...201728276428
assessing long-term complications in patients undergoing immediate postmastectomy breast reconstruction and adjuvant radiation.the purpose of this article is to report the long-term rate and timing of complications associated with postmastectomy radiation therapy (pmrt) following immediate breast reconstruction in a large patient population.201728274406
[analysis of clinical characteristics and factors associated with short term outcomes in early term neonates].objective: to investigate the clinical characteristics of early term and full term neonates, and analyze the risk factors associated with short term outcomes in early term neonates. method: neonates with birth weight (bw) ≥2 500 g from year 2013 were analyzed retrospectively based on american congress of obstericians & gynecologists (acog) latest definition of term infants. according to inclusion and exclusion criteria, early term (gestational age 37-38 weeks) and full term(gestational age 39-40 ...201728273701
evaluation of the precision id ancestry panel for crime case work: a snp typing assay developed for typing of 165 ancestral informative markers.the application of massive parallel sequencing (mps) methodologies in forensic genetics is promising and it is gradually being implemented in forensic genetic case work. one of the major advantages of these technologies is that several traditional electrophoresis assays can be combined into one single mps assay. this reduces both the amount of sample used and the time of the investigations. this study assessed the utility of the precision id ancestry panel (thermo fisher scientific, waltham, usa ...201728273506
the possible role of diabetes in the etiology of laryngeal cancer.laryngeal cancer and oral cancer are not always correlated with genetic mutations, hpv infection, smoking, and alcohol abuse. in the absence of these risk factors, there is an increase on these cancers with a parallel increase of diabetes. the aim of this study is to verify if diabetes could be a risk factor for the laryngeal cancer.201728272002
a prospective study on predicting local recurrence of giant cell tumour of bone by evaluating preoperative imaging features of the tumour around the knee joint.to evaluate the role of medical imaging in predicting local recurrence of giant cell tumour of bone (gctb) by assessing the preoperative imaging features of gctb around the knee.201728271359
dictionary learning for sparse representation and classification of neural spikes.spike sorting is the problem of identifying and clustering neurons spiking activity from recorded extracellular electro-physiological data. this is important for experimental neuroscience. existing approaches to solve this problem consist of three steps: spike detection, feature extraction, and clustering. in our method, we use fisher discriminant based dictionary learning to learn dictionary, whose sub-dictionaries are class specific, and estimate discriminative sparse coding coefficients by mi ...201628269050
posterior decentering of the humeral head on shoulder mr arthrography: significant association with posterior synovial proliferation.the purpose of this study is to analyze mri findings associated with posterior decentering of the humeral head on shoulder mr arthrogram.201728267370
prostate imaging reporting and data system, version 2, assessment categories and pathologic outcomes in patients with gleason score 3 + 4 = 7 prostate cancer diagnosed at biopsy.the purpose of this study is to assess associations between prostate imaging reporting and data system, version 2 (pi-radsv2), categories and the presence of a tumor with a gleason score (gs) of 4 + 3 = 7 or greater or the presence of extraprostatic extension (epe) at radical prostatectomy (rp) in patients with a gs 3 + 4 = 7 tumor at biopsy.201728267359
out of amazonia: the unexpected trans-andean distribution of <i>cochranella</i> <i>resplendens</i> (lynch and duellman, 1978) (anura: centrolenidae).the glassfrog genus cochranella, with nine recognized species, is distributed in the lowlands and mid elevation of the neotropical forests, from nicaragua to bolivia (guayasamin et al. 2009; twomey et al. 2014). four species are trans-andean-c. granulosa (taylor 1949) occurs in the lowlands and mountains, at mid elevation, of central america, c. litoralis (ruiz-carranza & lynch 1996) and c. mache guayasamin & bonaccorso 2004 occur in the pacific lowlands and the western cloud forests of colombia ...201728264259
the fisher technique for correction of penile torsion in children: who are the candidates?to report our experience in the treatment of penile torsion with a special reference to the fisher technique.201728263821
the optimal rate for resolving a near-polytomy in a phylogeny.the reconstruction of phylogenetic trees from discrete character data typically relies on models that assume the characters evolve under a continuous-time markov process operating at some overall rate λ. when λ is too high or too low, it becomes difficult to distinguish a short interior edge from a polytomy (the tree that results from collapsing the edge). in this note, we investigate the rate that maximizes the expected log-likelihood ratio (i.e. the kullback-leibler separation) between the fou ...201728263815
finite-size effects on bacterial population expansion under controlled flow conditions.the expansion of biological species in natural environments is usually described as the combined effect of individual spatial dispersal and growth. in the case of aquatic ecosystems flow transport can also be extremely relevant as an extra, advection induced, dispersal factor. we designed and assembled a dedicated microfluidic device to control and quantify the expansion of populations of e. coli bacteria under both co-flowing and counter-flowing conditions, measuring the front speed at varying ...201728262769
on the impact of smoothing and noise on robustness of ct and cbct radiomics features for patients with head and neck cancers.we investigated the characteristics of radiomics features extracted from planning ct (pct) and cone beam ct (cbct) image datasets acquired for 18 oropharyngeal cancer patients treated with fractionated radiation therapy. images were subjected to smoothing, sharpening, and noise to evaluate changes in features relative to baseline datasets.201728261818
alternatives to acellular dermal matrix: utilization of a gore dualmesh sling as a cost-conscious adjunct for breast reconstruction.objective: this study seeks an alternative to acellular dermal matrix in 2-staged breast reconstruction while minimizing cost. it was hypothesized that use of a gore dualmesh would allow for similar intraoperative tissue expander fill volumes, time to second-stage reconstruction, and number of postoperative fills compared with acellular dermal matrix at only a fraction of the expense. methods: retrospective analysis comparing gore dualmesh (59 breasts, 34 patients), acellular dermal matrix (13 b ...201728261372
immunohistochemical and molecular characterizations in urothelial carcinoma of bladder in patients less than 45 years.bladder tumours in early-onset patients are rare and seem to exhibit unique clinicopathological features. only few studies have investigated somatic alterations in this specific age of onset group and evidence is accumulating of a distinct molecular behaviour of early-onset bladder tumours. we collected the largest cohort of early-onset tumours of patients 45 years old or younger and aimed to test genomic alterations typically found in bladder cancer. tumours of 118 early-onset patients were com ...201728261332
classification of alzheimer's disease and prediction of mild cognitive impairment-to-alzheimer's conversion from structural magnetic resource imaging using feature ranking and a genetic algorithm.we developed a novel computer-aided diagnosis (cad) system that uses feature-ranking and a genetic algorithm to analyze structural magnetic resonance imaging data; using this system, we can predict conversion of mild cognitive impairment (mci)-to-alzheimer's disease (ad) at between one and three years before clinical diagnosis. the cad system was developed in four stages. first, we used a voxel-based morphometry technique to investigate global and local gray matter (gm) atrophy in an ad group co ...201728260614
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