relative tissue distribution of radioactivity in rats with endocrine "autonomous" breast carcinomas after 3h-,99mtc-, and 64cu-bleomycin.the localization of 64cu-, 3h-, and 99mtc-labeled bleomycin was studied in tissues of fisher rats bearing an endocrine autonomous breast tumor. the 64cu-bleomycin showed a greater uptake than 3h- and 99mtc-bleomycin in the breast tumor at all time intervals studied, from 2 to 72 hr after the tracer. this same differential uptake was shared by the liver and kidney.197545938
alpha benzene hexachloride inhibition of aflatoxin b1-induced hepatocellular carcinoma. a preliminary report.alpha benzene hexachloride protected against the development of liver carcinoma in male albino fisher rats ingesting aflatoxin b1.197881137
interaction of bacterial cell wall polymers and rat macrophages.processing of group a and group d streptococcal cell wall was measured after phagocytosis by normal rat peritoneal cells in tissue culture. group a cell wall was practically non-biodegradable in contrast to group d, which was over 80% degraded by 4-8 days in culture. there was no difference in elimination or degradation of mucopeptide or polysaccharide of group a cell walls. neither antiserum or sensitized lymphocytes affected persistence. macrophages from fisher rats (susceptible to group a cel ...1975126561
[quantitative study of serotonin-containing cells in fetal rabbit duodenum].in order to attempt identification in vitro of parameters involved in the cellular differenciation, it was necessary to possess a standard material with identical content and distribution of serotonin cells; these two properties are investigated in this paper. falck's technic is the only sensitive and specific method in demonstrating serotonin young cells devoid of argentaffinity. from 21, 22, 23 and 25 days old rabbit foetuses, 10 mm length duodenal pieces were treated according to falck and se ...1975129233
development of hyperlipidemia associated with increased lipolytic response of isolated adipose tissue cells following prolonged stimulation by an ectopic pituitary tumor.implantation of mtt-f4 tumor, a mammotropic tumor that secretes large quantities of acth, gh and prolactin, into male fisher rats induced the development of hyperlipidemia. free fatty acid, triglyceride and cholesterol levels in the plasma were significantly increased at 31 days after tumor implantation. blood glucose and glycerol levels remained normal, while uric acid concentration in the blood was significantly decreased. the lipolytic response of isolated adipose tissue cells to acth was sig ...1978217811
[role of normal microflora in the treatment of vibrio carrier state in rat gnotobionts].materials on the study of interactions between vibrio cholera el tor and some indigenous bacteria of human intestinal tract, which proved to be active antagonists in vitro, are presented in this work. experiments were conducted on gnotobiotic rats (fisher), using various combinations and variants of the order of the microorganism administration; there were revealed no antagonistic relations between virbrio cholerae el tor and escherichia coli m-17, lactobacillus fermenti, lactobacillus plantarum ...1978352437
exotoxin production by clinical isolates of pseudomonas aeruginosa.seventy-five consecutive clinical pseudomonas aeruginosa isolates were tested for in vitro exotoxin production. exotoxin was demonstrated in culture filtrates biologically, by its ability to produce characteristic dermonecrotic lesions in guinea pigs, and seriologically, by counterimmunoelectrophoresis (cie) with rabbit antiserum elicited with purified exotoxin. by these two methods, exotoxin was detected in 87 and 89% of p. aeruginosa strains, respectively (r = 0.48, p less than 0.001). althoug ...1977404244
analytical characterization of lipopolysaccharide antigens from seven strains of pseudomonas aeruginosa.lipopolysaccharide antigens from seven different serotype strains (antigen immunotypes nos. 1-7 in the classification of fisher et al.3) of pseudomonas aeruginosa have been analyzed for neutral carbohydrate, amino sugars, lipid, protein, 3-deoxy-manno-octulosonic acid, and phosphorus. the individual amino sugars were determined for each antigen type; all contained 2-amino-2-deoxy-d-glucose and -d-galactose, together with 2-amino-2,6-dideoxygalactose; the latter as isolated from the type 2 antige ...1977405103
an animal model for the study of prostatic adenocarcinoma.after the injection of the potent carcinogen 9,10-dimethyl-1,2-benzanthracene (dmba) male rats (fisher/furth), mice (strong a/j), and golden hamsters, which had been previously conditioned by castration and in which the prostate had become histologically atrophic, developed tumors consistent with prostatic adenocarcinoma. one month after castration, intravenous injections of dmba were given in the vena cava or jugular vein once a month for 3 months. three to four months later, histologic evidenc ...1977406218
schistosoma intercalatum fisher, 1934 (cameroon) infection in the patas monkey (erythrocebus patas schreber, 1775). 1978415994
the mechanism of peripherally evoked responses in retinal ganglion cells.1. responses to stimulation of retinal regions remote from the classical receptive field were recorded from optic tract fibres in lightly anaesthetized cats. 2. x- and y-cells gave reliably different responses to the sudden reversal of the phase of a high contrast grating that fell on the retina more than 15 deg from the centre of the receptive field. 3. the mechanism that generates these responses ('shift effect' or 'periphery effect') in y-cells is insensitive to the spatial phase of the stimu ...1979458660
hyperlipoproteinemia induced by a transplantable pituitary tumor in the rat.the mtt-f4 tumor, a transplantable pituitary tumor of rats, induces significant hyperlipidemia in male fisher 344 rats. the increasive hypercholesterolemia was accompanied by hypertriglyceridemia only in the first month of tumor implantation. clofibrate feeding inhibited the development of hypercholesterolemia and maintained normal serum triglyceride levels. in contrast to the changes in lipoprotein cholesterol distribution and profile found in experimental hyperlipidemia induced by high fat and ...1979465111
hybridization and heat tolerance in rats.buffalo and fisher inbred rats and their f1--f4 hybrids were exposed to heat, 96 degrees f and 30% humidity, at 35 days of age. fisher rats which are of lighter weight survive significantly longer than buffalo rats which are heavier. body weight was significantly depressed in all hybrids. only in f2 hybrids was heat tolerance similar to that of the fisher inbreds. in all other hybrids, it was lower. no heterosis was found under the conditions used.1979525249
[action of cyclophosphane on the formation of hemagglutinins and of nonspecific immunoglobulins in a microbe-free state].a total of 39 germ-free and 28 conventional germ-free fisher rats were used to study cyclophosphamide-induced specific (hemagglutinins) and nonspecific (igg2) immunosuppression. most pronounced effect of the drug was observed in germ-free animals. 180 mg/kg of cyclophosphamide completely suppressed hemagglutinin formation for at least 8 weeks.1979442887
genetic control of the immune response to ferritin in f1 hybrid mice.the immune response to the antigen horse spleen ferritin, has been investigated in ten inbred parental strains and seven different f1 hybrid strains of mice, using an antigen excess technique. the degree of dominance in an f1 hybrid system can be estimated by using the fisher dominance index. the responses in f1 hybrid animals, obtained from crosses of high and low responder parents, varied from dominant to recessive but the overall mean dominance index for the ferritin immunogenetic system was ...1977415964
age pigments, cell loss and hippocampal function.the specific aims of this study were to perform direct correlational analyses of age differences in learning, short-term memory and arousal in relation to cell loss and lipofuscin increase in the hippocampus ca1 zone and in visual area 17 of the fisher 344 rat. the following tentative conclusions can be made from the results presented in this study: (1) significant age differences in 2 and 6 hour passive-avoidance retention or memory between mature and old rats were related to non-significant ag ...1979571502
helminth parasites of fisher martes pennanti (erxleben) from manitoba, species of helminths were recovered during a survey of 162 fisher (martes pennanti) from four areas of manitoba: baylisascaris devosi in 52 fisher; taenia sibirica in 25; physaloptera sp. in nine; alaria mustelae in two; metorchis conjunctus in one; trichinella spiralis in one of 81; molineus sp. in one. b. devosi was the most prevalent parasite and differences in its geographical distribution were possibly related to population density of fisher. the prevalence of other parasites did not ...1979574167
morphologic and biologic correlation of hyperplastic and neoplastic renal lesions occurring in buffalo and fischer strain rats ingesting n-4-(4'-fluorobiphenyl) acetamide.hyperplastic and neoplastic lesions of the kidney induced in inbred buffalo and fisher strain rats with 0.04% n-4-(4'-fluorobiphenyl) acetamide were transplanted s.c. to rats of the same strain. hyperplastic renal lesions ("areas" or nodules) did not survive and grow. carcinomas of the kidney grew and killed the animals. growth was related to the size and the degree of differentiation of the carcinoma. it is concluded that the histologic pattern of hyperplastic and neoplastic lesions of the kidn ...1977601879
experimental evaluation of nonspecific immunostimulation and chemotherapy in the intracranial tumor-bearing fisher hundred sixty rats bearing intracranial tumors were divided into groups of 10 to evaluate c-i interval +, effect of chemotherapy alone (bcnu), chemotherapy and c. parvum, and c. parvum alone in the rat tumor model. all therapy was administered intraperitoneally: bcnu -5.2 mg/kg (40% of ld10) on the 9th and 16th post tumor implant day, and c. parvum-1.4 mg regardless of the body weight and the 6th or 23rd day and 6th and 23rd post tumor implant day. an additional group received bcnu on the 9t ...1977608518
[effects of methamphetamine and enriched experience on behavioral recovery after brain damage (author's transl)].two factorial experiments (brain status x environment x drug) were designed to measure the effects of methamphetamine and enriched experience on recovery after bilateral cortical lesions. fisher male rats were operated or sham operated when 30 days old and thereafter raised in either an enriched (ec) or impoverished (ic) condition while daily injected with either methampheteamine (2 mg/kg) or saline. in ec, 12 rats lived together in a large cage with stimulus objects that were changed daily. in ...1977403543
selective lymphoid irradiation. i. an approach to transplantation.the kinetics, distribution, and radiobiologic effects of palladium (pd)-109-hematoporphyrin were determined in the rat. in addition, we studied the effect on rat heart allograft survival of pd-109-hematoporphyrin, with and without antilymphocyte serum (als). a single sublethal dose of pd-109-hematoporphyrin (up to 36 muci/kg) resulted in the following: predominant concentration in lymphoid tissue and proximal bone marrow, complete central and proximal bone marrow ablation with preservation of di ...1979380034
the capacity of histocompatibility antigens solubilized in hypertonic salt solution to induce allograft tolerance in rats.treatment of fisher rats (agb 1,26,28) with a soluble extract of histocompatibility antigens (sae) prepared from the liver of donor august rats (agb 5, 28, 31) associated with a few injections of anti-lymphocyte serum (als) provoked a specific prolongation of the median survival time of skin grafts from 27.6 +/- 11.4 days in als-treated controls to 55.1 +/- 8.8 days (p less than 0.01). the sae was obtained from liver homogenates by hypertonic kcl (3m) extraction. further purification by chromato ...1978350127
preliminary observation on the immunology of nerve allograft rejection.a preliminary experiment was devised to delineate the specificity of nerve allograft rejection. skin grafts were performed between inbred strains of fisher, agb1, and buffalo, agb6, rats to determine the time required for a first set rejection, which occurred at day 9. skin grafts also were performed two weeks after orthotopic placement of whole nerve or fascicular grafts. the rats that had previously been exposed to whole nerve showed skin graft rejection at six days, while those exposed to ner ...1978337545
dose response and time course effects of n,n-dimethyltryptamine on disruption of rat shuttlebox avoidance.n,n-dimethyltryptamine (dmt) was given (ip) in different doses (0.25, 0.5, 1.0, 2.0, 4.0, 8.0 mg/kg) in a randomized order to a group of ten rats (fisher 344/mai) who were trained to a high, stable base line of conditioned avoidance responding in the shuttlebox. dmt produced dose-dependent disruptive effects, as a sigmoid function, with 1.0 mg/kg the minimal dose causing disruption and progressively more disruption with increasing doses, reaching a plateau at the highest dose. the disruptive eff ...1977266950
experimental hyperlipidemia in rats.implantation of mtt-f4 tumor, a mammotropic tumor that secretes large quantities of acth, gh and prolactin, into male fisher rats induced the development of hyperlipidemia. free fatty acid, triglyceride and cholesterol levels in the plasma were significantly increased at 31 days after tumor implantation. blood glucose and glycerol levels remained normal, while uric acid concentration in the blood was significantly decreased. the concentrations of the serum lipoproteins were significantly increas ...1979224751
peptide mapping characterization of viral proteins generated in a cell-free coupled system for the transcription and translation of influenza virus a coupled cell-free system for the transcription and translation of the influenza mrna's, containing detergent-disrupted purified nws influenza virion and a micrococcal nuclease-preincubated rabbit reticulocyte lysate, five unglycosylated viral proteins (ns1, m, np, p1, and p3) were easily produced and isolated. their identification was based on the electrophoretic separation of peptide fragments resulting from their partial digestion with proteases of restricted specificity (d.w. cleveland, ...1978671587
experimental infection with schistosoma intercalatum (fisher, 1934) in the chimpanzee (pan troglodytes) and the gibbon (hylobates lar).two young chimpanzees (pan troglodytes) and two adult gibbons (hylobates lar), each exposed to 1,000 cercariae of schistosoma intercalatum (cameroon), were examined at 79 and 82 wk and 61 and 69 wk, respectively, post-infection. based upon worn returns and tissue egg deposits, these primates can be employed as hosts for experimental schistosomiasis intercalata. however, no histopathology was detected in the urogenital system.1978677377
growth control in simian virus 40-transformed rat cells: temperature-independent expression of the transformed phenotype in tsa transformants derived by agar selection.fisher rat fibroblasts (fr 3t3), transformed with the tsa30 mutant of simian virus 40 and selected by colony formation in soft agar, maintained the transformed phenotype at high temperature, whereas most transformants isolated from foci were found to undergo a phenotypic reversion toward the normal state in their saturation density, ability to grow in soft agar, and rate of 2-deoxyglucose transport. the temperature-independent phenotype observed in agar-selected transformants was not due to a re ...1978212596
impaired synaptic potentiation processes in the hippocampus of aged, memory-deficient rats.a series of neurophysiological experiments was performed on the schaffercommissural system of the hippocampus of aged and young anesthetized fischer rats. the aged fisher rats were previously found to exhibit retention performance deficits. no obvious differences were found between aged and young animals in amplitude, latency, stimulation threshold, or wave forms of typical synaptic responses when these were elicited by control (0.3 hz) stimulation pulses. further, the temporal curves of facilit ...1978208716
temperature-sensitive growth regulation in one type of transformed rat cells induced by the tsa mutant of polyoma virus.a fibroblast line of the 3t3 type with a low saturation density was established from fisher rat embryo cells. after infection with either wild-type or tsa mutant polyoma virus, transformants were isolated and cloned at 33 degrees c on the basis of their ability either to grow as dense foci on plastic in liquid medium (type n) or to form colonies in soft agar (type a). polyoma t antigen was detected in all of the transformed lines. the following growth characteristics were studied for both types ...1977201774
endogenous protein kinase inhibitors. purification, characterization, and distribution in different tissues.a thermostable inhibition of atp-protein phosphotransferase (ec (protein kinase) which is present in crude tissue extracts has been resolved by gel chromatography (sephadex g-100) into two molecular forms. these two forms will be referred to as type i and type ii inhibitor. the type i inhibitor (mr approximately or equal to 24,000) is specific for camp-dependent protein kinase and corresponds to the inhibitor described earlier (walsh, d. a., ashby, c. d., gonzalez, c., calkins, d., fis ...1977193848
[guillain barré- polyneuroradiculitis and fisher-syndrome in cytomegalovirus infections (author's transl)].in seven patients suffering from polyneuroradiculitis of the guillain-barré type and one case of fisher syndrome, a cytomegalovirus infection was found. the elevation of the virus-specific igm-antibodies was confirmed in all cases. the clinical course was severe and acute with respiratory disturbances, but complete remission occurred within 1-4 months. the complement fixing antibodies were highest during the first week of illness, so that further elevations could not be demonstrated, therefore m ...1976189727
fructose-1,6-bisphosphatase from young and adult rats.fructose-1,6-bisphosphatase (e.c. was purified from the livers of young (69-86 days) and adult (370-386 days) fisher rats. the enzyme preparations were examined for increasing amounts of missynthesized proteins by means of heat-inactivation as well as for differences in regulatory properties. no significant difference with respect to the fraction of rapidly heat-inactivated enzyme or km- and ki-values was found. these results do not support the hypothesis that error accumulation result ...1976178710
effect of antithymocyte globulin on islet of langerhans transplantation.lewis rats were treated with streptozotocin to induce hyperglycemia and glycosuria (400-600 mg/dl). transplantation of approximately 1,000 dissociated islets obtained from collagenase-treated pancreases from 4 donors will promptly correct induced diabetes. functional survival of islet allografts is related to genetic disparity between donor and recipient strains. in the closely matched fisher-to-lewis combination, islets functioned for a mean of 4.2+/-1 days while in the agb-incompatible wistar/ ...1978106312
synthesis of some 11h-indolo[3,2-c][1,8]naphthyridines.the preparation of some 11h-indolo[3,2-c] [1,8]naphthyridines (v), having oxygen functions at positions 3 or 3 and 10 or 3 and 8, as in steroidal active compounds, is described. compounds (v) were obtained using the fisher indole synthesis. the preparation of the parent nucleus: 11h-indolo [3,2-c] [1,8]naphthyridines (v n) is also described. some compounds were subjected to pharmacological screening, but none was found to be significantly active.1978744236
the rate of skin allografts within the prostate.there is good evidence demonstrating the absence of lymphatic drainage in the normal glandular prostate. in other organs, such as the brain and anterior chamber of the eye, this property is associated with an impaired response to foreign tissue antigens. we have examined the first set allograft survival of normal skin transplanted between strains of male inbred rats (lewis leads to fisher) to various sites including the prostate. the resulting data indicate that the prostate is not an immunologi ...1976786938
serotyping of pseudomonas aeruginosa isolates from patients with cystic fibrosis of the pancreas.pseudomonas aeruginosa isolates (173) from 144 patients with cystic fibrosis (cf) of the pancreas in seven hospitals were serotyped with the agglutination systems of homma (1974) and fisher et al. (1969). the two systems were complementary. strains from cf patients were much less likely to furnish a stable type on repetitive typing tests than strains from other patients. this was related to the frequent occurrence of mucoid p. aeruginosa strains. the 173 strains were divided among 11 homma serot ...1975809484
specific neutralization of defective spleen focus-forming virus in friend virus complex by rat antiserum.the spleen focus-forming virus (sffv), a rapidly transforming, replication-defective virus in friend virus (fv) complex that is readily neutralized by antisera directed against its helper virus, was examined for the presence of sffv-specific antigens. antisera prepared in fisher rats against an sffv-infected fisher rat embryo fibroblast line (sffv-fre) neutralized sffv effectively, but not friend-associated murine leukemia virus (f-mulv) whether the latter was tested alone or was mixed with sffv ...197990172
cordycepin inhibition of 3-methylcholanthrene-induced transformation in vitro.cordycepin (3-deoxyadenosine), an inhibitor of poly (a) synthesis, was found to inhibit the induction of the endogenous type "c" rna virus by 5-iodo-2'-deoxyuridine in a line of fisher rat embryo cells (h43) grown in vitro, and when continuously incorporated into the medium at those same concentrations, it was found to protect the cells from transformation by the chemical carcinogen 3-methylcholanthrene.197554927
a method for the routine assessment of fore- and hindlimb grip strength of rats and mice.a technique to measure the fore-and hindlimb grip strength of rats (adult and preweanling) and mice is described. the procedure utilizes inexpensive equipment, is rapid and efficient, and provides continuous level data. as a means of validating the sensitivity of the test, the effects of phenobarbital and chlordiazepoxide on the grip strength of adult fisher strain and sprague-dawley derived adult rats were investigated. dose-related decreases in fore- and hindlimb grip scores were observed in b ...1979551317
effects of carbon disulfide on motor function and responsiveness to d-amphetamine in rats.male, albino rats of the fisher strain were exposed to 2 mg carbon disulfide/l of air for 4 hours per day, 5 days per week for 6 weeks. neurobehavioral effects were not observed after 3 weeks of dosing, but hindlimb extensor responses and performance on the inclined screen (motor coordination) were impaired after 6 weeks of exposure. forelimb grip strength and exploratory locomotor activity were not affected. three weeks after cessation of dosing, recovery of function was observed. rats exposed ...1979551304
a comparison of the characteristics of two strains of schistosoma intercalatum fisher, 1934 in mice.schistosoma intercalatum from cameroon and zaire each have their specific snail intermediate host. hybridization experiments between s. intercalatum from cameroon and zaire have resulted in viable miracidia for only two generations. if the two strains are of the same species, cross breeding should be possible for several generations. this paper presents a comparison of the characteristics of the two strains of s. intercalatum in experimental infections in mice. worm return, male-female worm rati ...1979541492
the influence of diazepam administration in rats bearing the r3230ac mammary carcinoma.the growth of the r3230ac mammary carcinoma was studied in female fisher 344 rats that were treated with diazepam. diazepam at 250 micrograms/animal/day (2.5 mg/kg body weight) and 500 micrograms/day was administered for 4 weeks, starting 2 days before subcutaneous transplantation of uniform pieces of the tumour. tumour size was significantly increased in the group receiving 250 micrograms but was below the levels observed in the saline treated controls in those given 500 micrograms diazepam. pl ...1979552103
tolerance to amphetamine's facilitation of self-stimulation responding: anatomical specificity.further work on the phenomenon reported by leith and barrett, wherein tolerance was shown to develop to the well-known d-amphetamine-induced facilitation of self-stimulation, clearly indicates that the development of such tolerance is dependent on the location of the stimulating electrode. thirty-seven fisher or harlan rats were trained to bar press for hypothalamic stimulation (60 hz, ac). following several sessions during which small doses of d-amphetamine were administered to demonstrate faci ...1978638781
effect of oil composition on both adjuvant-induced arthritis and delayed hypersensitivity to purified protein derivative and peptidoglycans in various rat strains.we confirmed that, when immunized with a conventional complete freund adjuvant (water in oil), lewis rats were highly susceptible to adjuvant arthritis, fisher rats were less susceptible, and buffalo rats were much less susceptible. however, mycobacterial delipidated cells in squalane (squalane-type adjuvant) produced severe arthritis with almost 100% incidence even in the less susceptible rat strains except for buffalo rats. with regard to an immune response, freund complete adjuvant induced st ...1977892904
complement in graft versus host disease: il depletion of complement components during a systemic graft versus host reaction in the rat (38499).serum complement (c) and c components were examined during a systemic graft versus host (gvh) reaction in the rat. in our series of experiments (lewis times brown norway) f-1 hybrid rats (60-80g) were given 200 times 10-6 or 400 times 10-6 lewis spleen cells intravenously. clinical gvh disease appeared 5-7 days after cell injection. five of six rats in the experimental groups had a fall in levels of serum c2 (20-76%) and c4 (75-98%). only one of six rats in the control group had a significant fa ...1975236566
studies on schistosoma intercalatum fisher, 1934 and its intermediate snail host in the kisangani area, zaire. 1978677950
loss of synapses in the cerebellar cortex of the senescent rat.numbers of synapses were compared in the cerebellar cortex of adult (12 months of age) and senescent (25 months of age) male rats of the fisher-344 strain. the total number of axodendritic synapses was found to be 24% lower in the senescent rats as compared with adults. a differential analysis of synapses involving dendritic shafts and spines showed no significant change in numbers of synapses involving shafts, but a highly sigificant 33% decrease in numbers involving spines in senescent rats. t ...1979512301
the effect of halothane anaesthesia on liver regeneration.the effects of halothane and diethyl ether on the regenerating liver following 70 per cent hepatectomy were studied in fisher/344 (f) rats. our aim was to discover whether halothane administered repeatedly and over prolonged periods could influence the liver regenerative process or hepatocyte function. we also wished to know if the effects of halothane differed from those of diethyl ether. we found: 1. prolonged halothane or diethyl ether anaesthesia did not inhibit liver mitotic activity, even ...1978667672
assignment of nadh-cytochrome b5 reductase (dia1 locus) to human chromosome 22.nadh-cytochrome b5 reductase (dia1, ec. from human fibroblasts and from chinese hamster cells, both identified by immunologic studies, were clearly distinguished after polyacrylamide gel isoelectro-focusing followed by staining for nadh diaphorase activity. in thirteen independent man-hamster hybrids, the human enzyme dia1 presented a positive correlation with the human chromosome g22. eight hybrids were dia1(+) g22(+) and five hybrids were dia1(-) g22(-). these data agree with the rece ...1978669708
role of galactose in the antigenic properties of thyroglobulin.thyroglobulins (tg) from a "hot" human thyroid nodule and from fisher rats have been purified and the effects of progressive removal of sialic acid and galactose on the immunoreactive properties of the proteins were studied. terminal sialic acid and galactose were released by stepwise hydrolysis with neuraminidase and beta-galactosidase. agalacto-tg shows a slower electrophoretic mobility than native tg, but in polyacrylamide gel electrophoresis and immunoelectrophoresis it migrates in the same ...1976822669
measurement of acute and chronic behavioural effects of methamphetamine in the mouse.a simple and reliable method was developed for rating the dose-related behavioural effects of methamphetamine in male swiss albino mice for acute or chronic drug treatment. this procedure was based on a frequency count of certain behaviours made at 15-min intervals over a 90-min period following drug administration. the fisher randomization procedure was adapted to analyze behavioural data for the chronic studies. clear-cut, dose-related behavioural responses occurred following acute (+)-methamp ...1976823582
[carcinoid papillomatosis].papilomatosis carcinoides, presents clinical and histological characteristics that may be authentically described as a transition state between the benign papillomatous proliferations and spindle cell carcinoma. it involves a series of clinical conditions, that are described with different names that correspond to the condyloma accuminatum gigantum. [buschke and lowenstein) wartic carcinoma [ackerman], papillomatosis oral florid [rock and fisher], carcinomatoid [gilbert] profuse conjuntival papi ...19761035386
age differences in short-term memory and cell loss in the cortex of the rat.studies with human and animal subjects have indicated age declines in short-term memory and cell loss in the cortex. cell loss has been estamated by descriptive nonautomated methods. declines in short-term memory may be related to reduced learning, movtivation, motor capacity, or some combination of these factors. passive-avoidance tests of memory minimize these factors. direct correlational studies on learning and memory in relation to cell loss in the same subject are not feasible in man and t ...1978624457
effects of a zinc deficient diet upon fluid intake in the rat.zinc deficient rats demonstrate an increased intake of sodium chloride (nacl) containing solutions as compared to normal rats, presumably related to decreased taste acuity. the purpose of this study was to determine if zinc deficient rats would show altered intake of other solutions since changes in nacl intake may be reflective of serious pathophysiologic processes not related to taste. eight littermate pairs of inbred fisher cdf rats, 29 days of age, were divided into two groups and individual ...1977845680
haploidploidy and the evolution of the social insect.halminton (1) was apparently the first to appreciate that the synthesis of mendelian genetics with darwin's theory of natural selection had profound implications for social theory. in particular, insofar as almost all social behavior is either selfish or altruistic (or has such effects), genetical reasoning suggests that an individual's social behavior should be adjusted to his or her degree of relatedness, r, to all individuals affected by the behavior. we call this theory kinship theory. the s ...19761108197
is the biomechanical principle of 'antagonistic compensation' valid also on the genetic level?according to 'antagonistic compensation', appendicular bones rendered hypofunctional by surgical means, become shorter and more robust. in normal buffalo rats, appendicular bones are short and very robust and in fisher rats they are long and gracile. total body constitution is robust in buffalo rats and gracile in fisher rats. in grl rats, appendicular bones are short but body constitution is gracile and the robusticity of the appendicular bones is intermediate between fischer and buffalo rats. ...1977848266
distribution of 99mtc-1-thioglucose in rats: effect of administration route on pancreatic specificity.tissue distribution of 99mtc-1-thioglucose was studied in inbred albino fisher rats. high levels of radioactivity were observed in the kidney with concurrent low pancreatic levels and pancreas/liver ratios of 0.4 following intravenous administration of the agent. high pancreatic concentration were observed with pancreas/liver ratios of 4.0 after intraperitoneal administrations. future studies on pancreatic radiopharmaceuticals should avoid production of artificially high pancreatic values by int ...1977887787
adipocyte cholesterol storage: effect of experimental hypercholesterolemia in the order to more clearly define the influence of adipocyte size and plasma cholesterol on adipose tissue cholesterol storage, hypercholesterolemia was induced in male fisher rats at a time when body weight and adipocyte size become fixed. in one experiment (experiment 1), increasing amounts (0, 0.05, 0.5 and 5.0%) of dietary cholesterol were added to a fat-free, purified diet (sucrose-casein-cellulose) fed to 1 year old virgin males. in experiment 2, retired breeder rats were fed 0 or 5% cholest ...1979512709
host-parasite relationship of bulinus forskalii (ehrenberg) and schistosoma intercalatum fisher 1934, from cameroun.the susceptibility of 13 different b. forskalii strains from zaire, cameroun, gabon, senegal, rhodesia and tanzania and b. reticulatus wrighti aden has been tested to infection with schistosoma intercalatum from cameroun. the most common prepatent period was 23-28 days. b. forskalii from zaire, cameroun and gabon were excellent intermediate hosts with infection rates varying from 59-0 to 97-4% and with very low death rates, 0-28-4%. the strains from senegal and rhodesia had infection rates from ...19751151052
transport of deutherium oxide across isolated rat small intestine.1. transport of deuterium oxide from a luminal perfusate containing 1% d2o was studied in fisher & gardners (1974) isolated preparation of perfused rat small intestine. 2. the kinetics of appearance of d2o in the intestinal secretion at the serosal surface fitted well to a single exponential function. 3. the steady-state concentration of d2o in this secretion was not significantly different from the concentration in the luminal perfusate. 4. the total tissue water contained d2o at a concentratio ...19751177106
age-related changes in the lipid metabolism of fisher 344 rats.lipid metabolism of male fisher 344 rats aged 2-24 months was studied. serum and liver cholesterol levels did not display the age-related gradual increase seen in other rat strains. an increase in the serum plus liver cholesterol pool from 2 to 6 months was followed by a plateau through 18 months and then another increase at 24 months of age. the triglyceride pool increased from 2 to 6 months and then remained unchanged through 24 months of age. cholesterol synthesis from acetate decreased 50% b ...1976972580
the evolution of epistasis and the advantage of recombination in populations of bacteriophage t4.experiments reported here test two hypotheses about the evolution of recombination: first, the fisher-muller concept that sexual organisms respond to selection more rapidly than do asexual ones, and second, that epistasis is more likely to evolve in the absence of recombination. populations of bacterio-phage t4 were selected by the drug proflavine in discrete generations and the change in mean population fitness was monitored. three separate selection series yielded results supporting the fisher ...1977892424
[development of resistance in fisher lymphadenosis cells to dipin and bruneomycin when these preparations are used separately and in combination].it was shown that dipin and bruneomycin resistant tumor cells appeared in mice with transplanted lymphadenosis after 10 passages on single use of the drugs. when the drugs were used in combination, no lymphadenosis cells resistant either to bruneomycin, or to dipin and their combination were found. the combined use of the drugs prevented development of resistance to them in the lymphadenosis cells at least during 10 passages on mice. the data on the possible prevention of the resistance developm ...19751211895
the relative capacity of corneal, heart, kidney and skin cells to stimulate allogeneic stimultaneous experiments, the ability of inbred wistar-furth rat corneal cells to stimulate inbred fisher rat lymphocytes in mixed culture was compared with the stimulatory capacity of the same number of wistar-furth skin, kidney, heart and lymphocyte cells. the tissue cells were dissociated and after inhibition by mitomycin c cultured with an equal number of allogeneic spleen lymphocytes for 5 days. in all of these mixed cell cultures, the allogeneic lymphocytic response was mainly to the m ...1979437826
selective effect on t and b cell subpopulations in rat lymphoid organs after urethan vitro phytohemagglutinin (pha) and concanavalin a (con a) responsiveness of thymus and bone marrow cells, and e, ea, and eac rosette-forming cells (e, ea, eac) of these organs and spleen were studied in fisher rats at various time intervals following a carcinogenic treatment with urethan (ur). immediately after treatment, organ cellularities were drastically reduced with a progressive recovery as time passed. 1 day after treatment, the response of thymocytes to pha showed a fourfold increase ...19761083833
cloning and surface expression of pseudomonas aeruginosa o antigen in escherichia a step toward developing recombinant oral vaccines, we have explored the feasibility of expression of o polysaccharide antigens from pseudomonas aeruginosa by escherichia coli. we cloned in e. coli hb101 a 26.2-kilobase dna fragment from p. aeruginosa strain pa103 that specifies the production of the o polysaccharide of fisher immunotype 2 (it-2) strains. the recombinant organism incorporated the p. aeruginosa it-2 o polysaccharide onto the core of the e. coli lipopolysaccharide (lps). transf ...19921279692
creativity and body image boundaries.descriptions of the creative individual or the individual who can regress in the service of the ego seem to parallel fisher and cleveland's (1968) description of the high barrier individual: well-integrated; self-sufficient, but often outgoing and communicative; and able to experience a full range of sensation and emotions without neurotic anxiety. the relationships between barrier and five measures associated with creativity were investigated, using 100 paid male college student volunteers. the ...1976943498
survival of normal and magnesium-deficient erythrocytes in rats: effect of magnesium-deficient diet vs. splenectomy.magnesium deficiency in rats causes anemia, the mechanism of which is unknown. the effect of dietary magnesium, splenectomy, and magnesium content of erythrocytes on erythrocyte survival was studied in fisher rats. half of the animals were splenectomized, the remainder sham-splenectomized; each group was subdivided, and some were placed on a magnesium-deficient diet, the rest on a control diet. after 6 weeks, each of the four subgroups was divided, half were given 51cr-labeled red cells from mag ...1978641390
hybridization between different strains of schistosoma intercalatum fisher, 1934 from cameroun and zaïre.the offspring from hybridization experiments between schistosoma intercalatum, cameroun (intermediate host bulinus forskalii) and s. intercalatum, zaïre (intermediate host b. globosus) was investigated. reciprocal crosses between the two forms were performed. f1- and f2-miracidia developed in both parental intermediate hosts. the minimum prepatent period was 24 days at 26 degrees c, an average of the prepatent periods for the two parental strains. the total cercariae production per 100 exposed s ...1978659822
automated rodent respiratory monitor and histogram computer--a preliminary report.the system described in this paper was designed to monitor total inhaled volume (v), tidal volume (vt), and respiratory frequency (f) of fisher rats before, during, and after exposure to cigarette smoke. the systems consists of three major subsystems: plethysmograph, analog signal conditioner, and histogram computer. the volume type whole body plethysmograph incorporates a rubber nose seal. tidal flow rate (v) from the tube, measured by a pneumotachometer, is integrated by the signal conditionin ...1976977275
androgen receptor dependent and independent activities of testosterone on hepatic microsomal drug metabolism.administration of testosterone for 6 days to intact female and castrate male balb/cj mice stimulated hepatic microsomal ethylmorphine n-demethylase activity and cytochrome p-450 content by 50-75%. testosterone also stimulated hepatic microsomal nadph-oxidase activity, but to a lesser degree. to probe the mechanism of this effect of androgens, two antiandrogens (cyproterone acetate and flutamide) were employed. since cyproterone acetate was a potent stimulator of hepatic microsomal ethylmorphine ...1976991826
feminization of hepatic s metabolism in male rats with a transplanted (mtt/f4).after transplantation of mtt/f4 pituitary tumor cells to male rats of the fisher strain, the masculine type of hepatic steroid metabolism was changed into a feminine pattern of enzyme activities. liver metabolism of steroid hormones in female rats was relatively unaffected following transplantation of pituitary tumor cells. futhermore, extract from mtt/f4 tumors and "autonomous" pituitary tissue increased the 5alpha-reductase activity of hepatoma cells in the culture (htc cells) at subsaturation ...1976947549
constitution and body proportions in different strains of rats. a study of race formation in breeding isolates.(1) there are considerable differences in body constitution in different strains of rats, ranging from very robust to very gracile forms. the differences are greater in the larger males than in the smaller females. (2)craniofacial and postcranial proportions of the trunk in domesticated strains of rats differ either uniformly or mosaically from the wild form. (3)nasal shape differs greatly in rats ranging from extreme leptorrhine to extreme platyrrhine forms, giving a total range greater than in ...1976961343
isolation and characterization of two benzene-derived hemoglobin adducts in vivo in rats.the present study was aimed at the characterization of the major adducts formed by reaction of the metabolites of [14c]benzene with rat hemoglobin in vivo. groups of 12-week-old male fisher rats received i.p. injections of a single dose of 10 mmol/kg body weight or three equal daily subdoses of 3.3 mmol/kg body weight of [14c]benzene. high-performance liquid chromatographic analysis of strong acid hydrolysates of the [14c]benzene-modified globin indicated that the two major adducts in rats cochr ...19921303132
[change in the concentration and non-homogeneity of rna and sh-group distribution in pyramidal neurons of cat cerebral cortex following epileptiform activity].concentrations of rna and sh-groups were determined in pyramidal neurons of somatosensory cortex of the intact cats and after epileptiform activity induced by electrical stimulation. the mean concentrations of rna and of sh-groups and the fisher information exponent were calculated in different zones of the pyramidal neuron cytoplasm zone of the apical dendrite and that of the axon departure. with epileptiform activity, rna and sh-group contents and the information exponent were seen decreased. ...1978695011
on factors possibly restricting the distribution of schistosoma intercalatum fisher, 1934.two hypotheses have been postulated explaining the limited distribution of schistosoma intercalatum. the first hypothesis is correlated with physical factors and behaviour of cercariae. histochemical and ultrastructural studies have shown that in response to increased temperature change the cercariae of s. intercalatum form aggregates, unlike other schistosome cercariae of man, which are non-infective to the definitive host. the aggregates are formed by the release of the adhesive post-acetabula ...1978695826
effects of the combination of lipopolysaccharide-specific monoclonal antibodies and sparfloxacin against pseudomonas aeruginosa pneumonia in neutropenic mice.the effects of the combination of a murine monoclonal antibody (mab) specific for the o side chain of pseudomonas aeruginosa fisher immunotype 1 lipopolysaccharide and sparfloxacin in a neutropenic mouse model of p. aeruginosa pneumonia were examined. under the condition that neither mab at a dose of 500 micrograms per mouse administered intravenously nor a suboptimal dose of oral sparfloxacin (5 mg/kg of body weight) protected mice from challenge with a fatal dose, the combination therapy with ...19921324643
[effect of microbial and tumor cell adaptation to rubomycin on their uptake of rubomycin and carminomycin].anthracycline antibiotics rubomycin (daunomycin) and carminomycin rapidly accumulated in the bacterial and ascitic tumor cells and their intracellular concentrations significantly exceeded the concentrations in the medium. the strains of staph. aureus and fisher mouse ascitic lymphadenosis l-5178/p resistant to rubomycin preserved sensitivity to carminomycin. the resistance of the bacterial and tumor strains to rubomycin was accompanied by a significant decrease in the accumulation of rubomycin ...1978697342
growth behavior of low passage cultured cells derived from human non-small cell lung carcinoma in deepithelialized rat tracheas transplanted into nude mice.proliferation behavior of six low passage cell lines derived from human non-small cell lung carcinoma was investigated both by cell inoculation into deepithelialized fisher 344 rat tracheas xenotransplanted into nude mice and by direct cell injection into the subcutis of nude mice. in the tracheal transplants, all the cell lines showed a comparable or higher degree of differentiation than in the primary lesion, while most cell lines showed a lower degree of differentiation in the mouse subcutis. ...19921325571
[effect of normal microflora, age and sex of rats on serum igg2 levels].germfree and conventional rats of fisher inbred strain and mongrel animals were used in this study. igg2 was separated from the pool serum of mongrel rats, and anti-igg2 was obtained by hyperimmunization of rabbits. igg2 content was determined by in the sera of different groups of rats radial immunodiffusion. there was 5.4 times less igg2 in the sera of fisher germfree rats than in conventional fisher animals; its level in female animals was by 10--15% higher than in the male ones. the first hou ...1978698380
histology and ultrastructure of the r-3327 c-f transplantable prostate tumor of cophenhagen-fisher rats.the r-3327 c-f tumor is an adenocarcinoma of the prostate maintained by serial transplantation in male copenhagen-fisher hybrid rats. the tumor is histologically different from other tumor sublines derived from the original r-3327 tumor discovered in 1961 in an aged copenhagen rat. light and electron microscopy have shown that the r-3327 c-f tumor contains a well organized glandular epithelium with myoepithelial cells and a continuous basement membrane, although epithelial cells were much less d ...1978711418
metabolic clearance of endogenous and radioiodinated thyroglobulin in rats.the basal concentration and metabolic clearance of radiolabeled and endogenous thyroglobulin (tg) were measured in normal male rats. serum tg concentrations (by ria) in sprague-dawley adult males ranged from 70-680 ng/ml (mean +/- sd, 218 +/- 177). in male fisher rats, basal serum tg concentrations were 32-263 ng/ml. the fractional disappearance rate of endogenously radioiodinated rat tg and of endogenous rat tg after thyroidectomy were both about 8%/h. the mcr of endogenously labeled tg was 2.4 ...1978744090
experimental chronic serum sickness in rats. a model of immune complex glomerulonephritis and systemic immune complex deposition.this article describes a method of immunization that produces chronic serum sickness in rats within a relatively short time. fisher rats, which were immunized subcutaneously three times with bovine serum albumin (bsa) in adjuvant, responded with high titers of antibodies to bsa. 2 weeks after the third subcutaneous immunization, daily increasing amounts of bsa were injected either intraperitoneally or intravenously. when an intravenous dose of 2mg of bsa was reached, the rats were given daily in ...1979156700
elevated expression of thymidylate synthase in doxorubicin resistant human non small cell lung carcinomas.human non-small cell lung carcinomas of previously untreated patients were analyzed for expression of thymidylate synthase (ts) using immunohistochemistry. of the 94 tumors, 67 were positive for ts and 27 negative. a significant correlation between the expression of ts and the resistance to doxorubicin was found (p < 0.0001). eighty-four percent of the ts-positive tumors were resistant to doxorubicin, whereas of the 27 ts-negative tumors only 44 percent were resistant. a group of patients (n = 1 ...19921338282
age-associated reduction in pineal beta-adrenergic receptor density is prevented by life-long food restriction in 28 months of age (old rats), male fisher 344 rats which had been fed 40% of the ad libitum food intake since they were 6 months old, had a similar beta-adrenergic receptor density (bmax) in their pineal gland as young, 3-month-old rats. in contrast, old rats which had been fed ad libitum for the same period had approximately 50% of the bmax value compared to that of young rats. the beta-receptor density of cerebral cortical tissue and the beta-receptor affinity (kd) of both the cortex and the ...19921339169
[cross resistance in tumor cells and staphylococci with respect to anthracycline-group antineoplastic antibiotics].the variants of the tumor cells of fisher lymphadenosis, strain l-5178 and staph. aureus resistant to rubomycin simultaneously became partially less sensitive to adriamycin. sensitivity to karminomycin in the rubomycin resistant strains did not practically change as compared to the sensitivity of the initial strains. sensitivity to adriamycin and rubomycin in staph. aureus decreased 67 and 4 times respectively after 7 passages on media with increasing concentrations of adriamycin, while sensitiv ...1976999240
hepatic phenylalanine 4-monooxygenase is a phosphoprotein.phenylalanine hydroxylase [phenylalanine 4-monooxygenase; ec; l-phenylalanine, tetrahydropteridine:oxygen oxidoreductase(4-hydroxylating)] isolated from rat liver is a phosphoprotein containing approximately 0.31 mumol of protein-bound phosphate per mumol of subunit (50,000 molecular weight). when the enzyme is further phosphorylated in the presence of atp and a 3'5'-cyclic-amp-dependent protein kinase (ec; atp:protein phsophotransferase), an additional 0.7 mumol of phosphate ...19761064028
erythrocyte membrane plaques from rats with magnesium deficiency.this study investigated the anemia of dietary magnesium deficiency in inbred fisher white rats using freeze-fracture electron microscopy. the plasma membranes of erythrocytes from animals receiving two different magnesium-deficient and control diets were observed at weekly or biweekly intervals for 6 wk. the earliest changes were small plaques on the external surface (es) and fracture face (pf) of erythrocyte plasma membranes, which occurred after 2 wk of either magnesium-deficient diet. these p ...1977843624
oxidative energy metabolism in germ-free and conventional rat liver mitochondria.the adp:o ratios and state 3 (adp-stimulated) and state 4 (controlled) rates of succinate, beta-hydroxybutyrate, isocitrate, glutamate, pyruvate + malate, alpha-ketoglutarate, and ascorbate + n,n,n',n'-tetramethylphenylenediamine (tmpd) oxidation were examined in liver mitochondria from germ-free and conventional rats of both lobund wistar (100-day-old) and fisher (120-day-old) strains. the state 3 respiration rates of isolated mitochondria from germ-free and conventional rats were comparable ex ...19751122009
endophthalmitis at the bristol eye hospital: an 11-year review of 47 patients.we reviewed data from 47 patients who were treated for endophthalmitis at our hospital during the 11-year period 1980-90. the most common clinical features were hypopyon (75%), diminished vision (72%), ocular pain (68%), discharge (57%), corneal oedema (51%), conjunctival injection (49%), abnormal red reflex (34%), corneal ulcer (32%) and corneal perforation (6%). a total of 54 isolates were obtained from 41 (87%) of the 47 patients. gram-positive bacteria were more common (72%), than gram-negat ...19921363106
a modification of the jump-flinch technique for measuring pain sensitivity in rats.the jump-flinch procedure provides a sensivite alternative to the hot-plate and tail-flick procedures. analysis of the components of motor responses to increasing intensity of foot shock presentation has allowed the observational discrimination of five reliably elicited categories of unlearned responses to inescapable foot shock. morphine sulfate differentially altered response category thresholds in rats. response category thresholds also differed between wistar and fisher strain rats in analge ...19751129354
[renal effects and metabolism of sevoflurane in fisher 3444 rats: an in-vivo and in-vitro comparison with methoxyflurane].sevoflurane, 1.4 per cent (mac), was administered to groups of fischer 344 rats for 10 hours, 4 hours, or 1 hour; additional rats received 0.5 per cent methoxyflurane for 3 hours or 1 hour. urinary inorganic fluoride excretion of sevoflurane in vivo was a third to a fourth that of methoxyflurane. however, using hepatic microsomes, sevoflurane and methoxyflurane were defluorinated in vitro at essentially the same rate. the discrepancy between defluorination of sevoflurane and methoxyflurane in vi ...19751147310
synthetic capacity and cell metabolites of bile duct obstructed rat livers. effect of free and conjugated dihydroxy bile acids.morphologic alterations in liver cells after bile duct ligation are well known and documented in numerous reports. biochemical studies concerning metabolic changes in cholestatic liver are rare. therefore, in this study, liver cell metabolites and the capacity of the perfused cholestatic rat liver to produce glucose, urea and ketone bodies were measured. in addition the influence of dihydroxy bile acids on normal and bile duct ligated rat livers was studied. concentrations of adenine nucleotides ...19751199667
influence of age on size and number of fat cells in the epididymal depot.the extensive literature on the effect of rat age on the size and number of adipocytes in adipose tissue depots relates solely to young developing rats and young adults. therefore a study was carried out in our laboratory on the cellular characteristics of the epididymal depot of the fisher 344 strain of rats through virtually the entire life-span. collagenase digests of this depot prepared from rats of 9, 13, 26, 52, 104, and 130 wk of age yield a population of cells with diameters greater than ...19751239957
synthetic peptides representing epitopes of outer membrane protein f of pseudomonas aeruginosa that elicit antibodies reactive with whole cells of heterologous immunotype strains of p. using the published amino acid sequence for mature outer membrane protein f of pseudomonas aeruginosa, a computer-assisted analysis was performed to identify sites with potential as surface-exposed, antigenic regions located throughout the length of the protein molecule. synthetic peptides 13 to 15 amino acid residues in length were synthesized for 10 such regions. mice were immunized with each of the 10 synthetic peptides conjugated to keyhole limpet hemocyanin. an enzyme-linked immunosorben ...19921379985
l-696,229 specifically inhibits human immunodeficiency virus type 1 reverse transcriptase and possesses antiviral activity in vitro.l-696,229 (3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methyl-pyridin-2 (1h)-one) is a specific inhibitor of human immunodeficiency virus type 1 (hiv-1) reverse transcriptase (rt) activity that possesses antiviral activity in cell culture (w.s. saari, j.m. hoffman, j.s. wai, t.e. fisher, c.s. rooney, a.m. smith, c.m. thomas, m. e. goldman, j. a. o'brien, j. h. nunberg, j. c. quintero, w. a. schleif, e. a. emini, and p. s. anderson, j. med. chem. 34:2922-2925, 1991). in the present study, the rt-inhib ...19921380788
[angiogenesis induced by rat glioma cells in vitro].angiogenesis induced by rat glioma cells was examined in vitro using a double chamber co-culture system. cultured microvascular endothelial cells from fisher 344 rat brain, rat c6 glioma cells and rat t9 gliosarcoma cells were used for this study. endothelial cells, cultured on type i collagen, formed capillary-like structures. in the co-culture system, c6 glioma cells promoted this formation. on the other hand t9 gliosarcoma cells had no effect on it. the supernatants of c6 glioma cells and t9 ...19921280347
[immunotherapy in ocular diseases].basic and clinical studies on immunotherapy in immune-mediated ocular disorders, i.e. uveitis, allograft rejection in corneal transplantation and allergic conjunctivitis, were carried out using a variety of immunosuppressants, including immunophilin ligands (fk506 and cyclosporine). 1. in an animal model for uveitis, experimental autoimmune uveitis (eau), immunophilin ligands were demonstrated in the rat and monkey to have unique immunological activities: (1) intense and prolonged suppression of ...19921283052
glutamine facilitates chemotherapy while reducing toxicity.dose intensification of chemotherapy is thought to increase survival. with recent advances in hemopoietic cell modulators such as granulocyte colony stimulating factor, the limiting toxicity of intensifying chemotherapeutic regimens has become the severity of the associated enterocolitis. in animal models, glutamine protects the host from methotrexate-induced enterocolitis. this study evaluates the effects of a glutamine-supplemented diet on the tumoricidal effectiveness of methotrexate. sarcoma ...19921287230
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