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bacterial contamination of ct equipment: use of atp detection and culture results to target quality improvement.this study aimed to evaluate the use of an adenosine triphosphate (atp) monitoring system to minimize surface contamination on inpatient computed tomography (ct) scanners.201728259604
female sex independently predicts mortality after thoracic endovascular aortic repair for intact descending thoracic aortic aneurysms.whereas sex differences in the pathogenesis, presentation, and outcomes of repair for abdominal aortic aneurysms are well studied, less is known about sex differences after thoracic endovascular aortic repair (tevar). the goal of this study was to evaluate the association between sex and morbidity and mortality after tevar.201728259576
research in pediatric residency: national experience of pediatric chief residents.to determine factors associated with increased research productivity, satisfaction, and perceived barriers to research within residency from the experience of pediatric chief residents.201728259335
guillain-barré syndrome.guillain-barré syndrome is an acute inflammatory immune-mediated polyradiculoneuropathy presenting typically with tingling, progressive weakness, and pain. variants and formes frustes may complicate recognition. the best known variant is the sensory ataxic form of miller fisher syndrome, which also affects the oculomotor nerves and the brain stem. divergent pathologic mechanisms lead to demyelinating, axonal, or mixed demyelinating-axonal damage. in the demyelinating form, yet to be identified a ...201728259232
association of oncogenic mutations in patients with advanced cutaneous squamous cell carcinomas treated with cetuximab.cetuximab was recently proposed for advanced cutaneous squamous cell carcinomas (cscc); however, its efficacy is inconsistent and identification of predictive biomarkers for response is necessary.201728259104
effects of starting a gastroenterology fellowship training program on quality measures of colonoscopy.adenoma detection rate (adr) is the most established indicator of the quality of screening colonoscopy. the effect of gastroenterology (gi) fellows on the quality of screening colonoscopies has been evaluated previously; however, the effect of starting a new gi fellowship program on the quality of screening colonoscopies has not been studied. the aim of our study was to assess the effects of starting a gi fellowship program and the participation of fellows in screening colonoscopies on adr and o ...201728257545
cytologic characteristics of circulating epithelioid cells in pancreatic disease.circulating epithelioid cells (cecs), also known as circulating tumor, circulating cancer, circulating epithelial, or circulating nonhematologic cells, are a prognostic factor in various malignancies that can be isolated via various protocols. in the current study, the authors analyzed the cytomorphologic characteristics of cecs isolated by size in a cohort of patients with benign and malignant pancreatic diseases to determine whether cytomorphological features could predict cec origin.201728257167
weak value amplification can outperform conventional measurement in the presence of detector saturation.weak value amplification (wva) is a technique by which one can magnify the apparent strength of a measurement signal. some have claimed that wva can outperform more conventional measurement schemes in parameter estimation. nonetheless, a significant body of theoretical work has challenged this perspective, suggesting wva to be fundamentally suboptimal. optimal measurements may not be practical, however. two practical considerations that have been conjectured to afford a benefit to wva over conve ...201728256865
quantum estimation methods for quantum illumination.quantum illumination consists in shining quantum light on a target region immersed in a bright thermal bath with the aim of detecting the presence of a possible low-reflective object. if the signal is entangled with the receiver, then a suitable choice of the measurement offers a gain with respect to the optimal classical protocol employing coherent states. here, we tackle this detection problem by using quantum estimation techniques to measure the reflectivity parameter of the object, showing a ...201728256851
a clinical trial comparing the effect of peer education and orientation program on the anxiety levels of pre-cabg surgery patients.background and objectives: one of the main treatment methods of coronary artery disease is coronary artery bypass graft (cabg) surgery. the anxiety level in patients undergoing this surgery is relatively very high. thus, reducing anxiety in these patients is an important step toward wellness. this study aimed to compare the effects of peer education (pe) and orientation program (op) on the anxiety levels of patients before cabg surgery. material and methods:this randomized controlled trial was c ...201528255400
prevalence of acute deep vein thrombosis in patients with ankle and foot fractures treated with nonoperative management-a pilot study.the prevalence of deep vein thrombosis (dvt) among patients with ankle and foot fractures in australia treated nonsurgically is unknown. indications for thromboprophylaxis screening and management are unclear. the primary outcome was the prevalence rate of dvt among nonsurgically managed ankle and foot fracture patients. patients were enrolled into a prospective cross-sectional pilot study at an outpatient hospital fracture clinic. dvt risk factors and symptoms were recorded at time of recruitme ...201728255217
non-uniform object-space pixelation (nuop) for penalized maximum-likelihood image reconstruction for a single photon emission microscope system.this paper presents a non-uniform object-space pixelation (nuop) approach for image reconstruction using the penalized maximum likelihood methods. this method was developed for use with a single photon emission microscope (spem) system that offers an ultrahigh spatial resolution for a targeted local region inside mouse brain. in this approach, the object-space is divided with non-uniform pixel sizes, which are chosen adaptively based on object-dependent criteria. these include (a) some known cha ...200928255178
fidelity of parent-offspring transmission and the evolution of social behavior in structured populations.the theoretical investigation of how spatial structure affects the evolution of social behavior has mostly been done under the assumption that parent-offspring strategy transmission is perfect, i.e., for genetically transmitted traits, that mutation is very weak or absent. here, we investigate the evolution of social behavior in structured populations under arbitrary mutation probabilities. we consider populations of fixed size n, structured such that in the absence of selection, all individuals ...201728254478
a clinicopathologic study on ss18 fusion positive head and neck synovial sarcomas.to determine clinicopathologic factors on survival in patients with head and neck synovial sarcoma.201728249647
amelioration of penetrating ballistic-like brain injury induced cognitive deficits after neuronal differentiation of transplanted human neural stem cells.penetrating traumatic brain injury (ptbi) is one of the major cause of death and disability worldwide. previous studies with penetrating ballistic-like brain injury (pbbi), a ptbi rat model revealed widespread perilesional neurodegeneration, similar to that seen in humans following gunshot wound to the head, which is unmitigated by any available therapies to date. therefore, we evaluated human neural stem cell (hnsc) engraftment to putatively exploit the potential of cell therapy that has been s ...201728249550
trends in fellowship training for female pelvic medicine and reconstructive surgery.the aim of this study was to characterize distinguishing features among gynecology, urology, and combined female pelvic medicine and reconstructive surgery (fpmrs) fellowship programs and practices.201728248848
[genetic risk factors for recurrence-free urolithiasis in the russian population].search for and identification of possible associations of recurrence-free urolithiasis with polymorphisms of urolithiasis candidate genes in the russian population.201628247721
scaphoid fracture and scaphoid pseudarthrosis.careful diagnostic and early therapy are especially important in cases of scaphoid fractures. this is due to the patients being mostly young and the high number of non-unions of these carpal bones. conservative and various operative treatments are therapeutical options. out of the patients who underwent surgery from january 1993 to february 1999 42 patients with a scaphoid fracture and 88 patients with a scaphoid non-union were, in addition to standard x-ray examination, examined clinically and ...199928246736
applying vacuum to accomplish reduced wound infections in laparoscopic pediatric surgery.the prevention of surgical site infections has received little attention in pediatric surgery. negative pressure wound therapy is used to treat complex wounds. we hypothesized that this principle could reduce wound infection rates following laparoscopic surgery. we tested this in a randomized controlled trial.201728245914
aneurysm rebleeding after placement of external ventricular drainage: a systematic review and meta-analysis.the association between external ventricular drainage (evd) and aneurysm rerupture is still a controversial issue. we performed a systematic review and meta-analysis of published series reporting data of evd placement in aneurysmal subarachnoid hemorrhage (sah) with the aim to evaluate the relationship between ventricular drainage and aneurysm rebleeding.201728243810
rod stiffness as a risk factor of proximal junctional kyphosis after adult spinal deformity surgery: comparative study between cobalt chrome multiple-rod constructs and titanium alloy two-rod constructs.little is known about the effect of rod stiffness as a risk factor of proximal junctional kyphosis (pjk) after adult spinal deformity (asd) surgery.201728242335
intensity-based axial localization approaches for multifocal plane microscopy.multifocal plane microscopy (mum) can be used to visualize biological samples in three dimensions over large axial depths and provides for the high axial localization accuracy that is needed in applications such as the three-dimensional tracking of single particles and super-resolution microscopy. this report analyzes the performance of intensity-based axial localization approaches as applied to mum data using fisher information calculations. in addition, a new non-parametric intensity-based axi ...201728241554
correlation between bile reflux gastritis and biliary excreted contrast media in the stomach.this study aimed to evaluate the relationship between biliary excreted contrast media in the stomach and the presence of bile reflux gastritis.201728240637
video-based pedestrian re-identification by adaptive spatio-temporal appearance model.pedestrian re-identification is a difficult problem due to the large variations in a person's appearance caused by different poses and viewpoints, illumination changes, and occlusions. spatial alignment is commonly used to address these issues by treating the appearance of different body parts independently. however, a body part can also appear differently during different phases of an action. in this paper we consider the temporal alignment problem, in addition to the spatial one, and propose a ...201728237930
using administrative data to look at changes in the level and distribution of out-of-pocket medical expenditure: an example using medicare data from australia.australia's universal health insurance system medicare generates very large amounts of data on out-of-pocket expenditure (oope), but only highly aggregated statistics are routinely published. our primary purpose is to develop indices from the medicare administrative data to quantify changes in the level and distribution of oope on out-of-hospital medical services over time.201728237388
pain locations in the postoperative period after cardiac surgery: chronology of pain and response to treatment.postoperative pain after cardiac surgery (cs) can be generated at several foci besides the sternotomy.201728237371
moderate hypofractionated postprostatectomy volumetric modulated arc therapy with daily image guidance (vmat-igrt): a mono-institutional report on feasibility and acute toxicity.the aim of this study was to evaluate the acute toxicity profiles of a moderate hypofractionated regimen with volumetric modulated arc therapy (vmat) in patients with prostate cancer (pc) who underwent radical prostatectomy.201728237181
double-read of skeletal surveys in suspected non-accidental trauma: what we learned.missing a fracture in a child on skeletal surveys for suspected non-accidental trauma can have devastating results. double-read has the potential to improve fracture detection. however the yield of double-read is unknown.201728236132
generalized wilson-fisher critical points from the conformal operator product expansion.we study possible smooth deformations of the generalized free conformal field theory in arbitrary dimensions by exploiting the singularity structure of the conformal blocks dictated by the null states. we derive in this way, at the first nontrivial order in the ε expansion, the anomalous dimensions of an infinite class of scalar local operators, without using the equations of motion. in the cases where other computational methods apply, the results agree.201728234506
factors influencing the need for endoscopic sinus surgery in adult patients with cystic fibrosis.risk factors in adult patients with cystic fibrosis (cf) associated with surgical intervention have not been delineated.201728234153
cement-within-cement technique in revision reverse shoulder arthroplasty.the purpose of this study was to determine the complications and results of cement-within cement-humeral fixation in revision reverse shoulder arthroplasty.201728233712
in vitro evaluation of three methods for the retrieval of fractured screw fragments from dental implants.to compare the effectiveness of different methods of fractured screw fragment retrieval from dental implants, comparing a conventional method (use of an exploration probe and ultrasonic tips) with two mechanical retrieval kits.201728231345
evaluation of a radiological score in the management of pure fractures of the orbital floor.the authors had for aim to further assess the predictive power and the relevance of a previously published radiological decision taking score for pure fractures with recording of clinical data.201728230595
safety and feasibility within 24 h of discharge in patents with inoperable malignant lung nodules after percutaneous microwave ablation.minimally invasive interventional therapy is now the more effective treatment strategy for organ-confined malignancy in patients who are poor candidates for surgery. microwave ablation (mwa) in lung malignancy has been receiving much attention as an effective minimally invasive approach.201628230012
[comparison of complications following open, laparoscopic and robotic gastrectomy].to compare clinically relevant postoperative complications after open, laparoscopic, and robotic gastrectomy for gastric cancer.201728226353
comparative efficacy of b-irradiation and mitomycin-c in primary and recurrent pterygium.to determine the efficacy and safety of mitomycin-c as adjunctive treatment and to compare this drug with beta irradiation with strontium-90 after surgical excision of primary and recurrent pterygia.201728226148
intimate partner violence reported by female and male users of healthcare units.to analyze nonfatal violence suffered and committed by adult men and women, in an intimate relationship.201728225908
takotsubo in miller-fisher and guillain barre syndrome. 201728222914
recurrent angioedema: occurrence, features, and concomitant diseases in an italian single-center study.angioedema (ae) is a potentially life-threatening condition with hereditary (hae), acquired (aae), or iatrogenic causes. a careful workup allows for the identification of the etiology of attacks and the appropriate management. in this cohort study, based on a clinical practice setting, we aimed at investigating clinical and laboratory findings concerning different features of patients with recurrent ae who were referred to a single, tertiary-level center for hae.201728222436
genome-wide methylation analysis of a large population sample shows neurological pathways involvement in chronic widespread musculoskeletal pain.chronic widespread musculoskeletal pain (cwp), has a considerable heritable component, which remains to be explained. epigenetic factors may contribute to and account for some of the heritability estimate. we analysed epigenome-wide methylation using medipseq in whole blood dna from 1708 monozygotic and dizygotic caucasian twins having cwp prevalence of 19.9%. longitudinally stable methylation bins (lsbins), were established by testing repeated measurements conducted ≥3 years apart, n = 292. dna ...201728221285
fusion of spatial gray level dependency and fractal texture features for the characterization of thyroid lesions.thyroid is a small gland situated at the anterior side of the neck and one of the largest glands of the endocrine system. the abrupt cell growth or malignancy in the thyroid gland may cause thyroid cancer. ultrasound images distinctly represent benign and malignant lesions, but accuracy may be poor due to subjective interpretation. computer aided diagnosis (cad) can minimize the errors created due to subjective interpretation and assists to make fast accurate diagnosis. in this work, fusion of s ...201728219805
early complications from the use of calcium phosphate paste in mandibular lengthening surgery. a retrospective study.calcium phosphate paste is used in mandibular lengthening surgery to avoid unesthetic notching at the lower border and to help stabilize the segments when osteosynthesis slippage is a concern. the aim of this study was to investigate whether the hardened paste increases the incidence of infections.201728219630
fenestrated endovascular aneurysm repair among octogenarians at high and standard risk for open repair.octogenarians with complex abdominal aortic aneurysms are at higher risk of death and morbidity after open repair. fenestrated endovascular aneurysm repair (fevar) is an alternative to open repair for high-risk patients, such as octogenarians. the aim of this study was to evaluate perioperative and midterm outcomes of fevar among octogenarians at high and standard risk for open repair.201728216359
the pattern and degree of capsular fibrous sheaths surrounding cochlear electrode arrays.an inflammatory tissue reaction around the electrode array of a cochlear implant (ci) is common, in particular at the electrode insertion region (cochleostomy) where mechanical trauma often occurs. however, the factors determining the amount and causes of fibrous reaction surrounding the stimulating electrode, especially medially near the perimodiolar location, are unclear. temporal bone (tb) specimens from patients who had undergone cochlear implantation during life with either advanced bionics ...201728216124
incidence of fever in labor and risk of neonatal sepsis.the current recommendation regarding the management of a term newborn delivered of a mother with an intrapartum fever or a diagnosis of clinical chorioamnionitis is that the neonate should have baseline laboratory work drawn along with blood cultures and be universally treated with antibiotics until culture results return. these guidelines report that the rate of intrapartum fever is about 3%; however, a few large studies suggest that the rate is higher at about 7%.201728216060
dietary intake, nutritional status, and body composition in children with end-stage kidney disease on hemodialysis or peritoneal dialysis.this study aimed to demonstrate that dietary intake, anthropometric indicators, and body composition in children with end-stage kidney disease differs between those on peritoneal dialysis (pd) and those on hemodialysis (hd).201728215492
association of toll-like receptor 4 single-nucleotide polymorphisms asp299gly and thr399ile with the risk of primary open angle glaucoma.toll-like receptor 4 (tlr4) is a transmembrane receptor that mediates immune responses to exogenous and endogenous ligands. previously, non-coding single nucleotide polymorphisms (snps) in the tlr4 gene were related to primary open angle glaucoma (poag). this study was undertaken to investigate whether coding tlr4 asp299gly (rs4986790 a/g) and thr399ile (rs4986791 c/t) are associated with poag in a mexican population.201728214954
oncoplastic breast conservation surgery is oncologically safe when compared to wide local excision and mastectomy.support for the oncological safety of oncoplastic breast conservation surgery (obcs) is mostly based on evidence comparing recurrence rates after obcs to wide local excision (wle). however, obcs is often indicated for larger cancers and oncological results should also be compared to patients treated with mastectomy. in this study we compared recurrence and survival following obcs, mastectomy and wle.201728214785
routine urethrography after buccal graft bulbar urethroplasty: the impact of initial urethral leak on surgical success.to determine the long-term impact of extravasation at initial post-urethroplasty urethrogram, we present a novel classification system and report the association of leak severity with outcome.201728214570
effect of reduction mammoplasty on acute radiation side effects and use of lumpectomy cavity boosts.reduction mammoplasty (rm) during breast-conserving surgery is popular among women with large-volume breasts because it reduces redundant breast folds and may decrease skin-related morbidity from radiation therapy. however, rm may obscure the lumpectomy cavity (lc) and pose challenges to administering an lc boost, potentially affecting local control. we investigated the impact of rm on acute side effects and use of lc boosts.201728214145
multiple cranial nerve neuropathies, ataxia and, areflexia: miller fisher syndrome in a child and review. 201728214063
mri findings of optic pathway involvement in miller fisher syndrome in 3 pediatric patients and a review of the literature.miller fisher syndrome (mfs) is a rare demyelinating condition which may have involvement of cranial nerves. there are a few case reports of optic pathway involvement in children. we describe 3 patients with optic pathway enhancement in pediatric patients with mfs.201728209311
aquaporin 3 and e-cadherin expression in perilesional vitiligo skin.vitiligo is a common dermatologic disorder with debated aetiology. most studies focused on role of melanocytes and few investigated the role of keratinocytes in pathogenesis of the disease.201628208984
role of routine subhepatic abdominal drain placement following uncomplicated laparoscopic cholecystectomy: a prospective randomised study.routine abdominal drainage after laparoscopy cholecystectomy is an issue of considerable debate. reason for draining is to detect early bile/blood leak and allow co2 insufflate during laparoscopy to escape via drain site thereby decreased shoulder tip pain and post-operative nausea and vomiting. but some studies show no difference in post-operative nausea /vomiting/pain between drain and no drain group.201628208922
study on distribution of scorpions to provide prevention and interventions in combating scorpionism in poldokhtar county, lorestan province, iran.scorpions are arthropods of medical importance classified in the class arachnida, inhabiting hot and dry environments. all scorpions have a venomous sting and several thousand people die each year from scorpion stings, but this mortality is due to the venom of about 25 species located in northern africa, the middle east, india, mexico and parts of south america. poldokhtar county belongs to one of the southern cities of lorestan province, providing suitable habitats for many different species of ...201628208885
beyond flory theory: distribution functions for interacting lattice trees.while flory theories [j. isaacson and t. c. lubensky, j. physique lett. 41, 469 (1980)jpslbo0302-072x10.1051/jphyslet:019800041019046900; m. daoud and j. f. joanny, j. physique 42, 1359 (1981)jopqag0302-073810.1051/jphys:0198100420100135900; a. m. gutin et al., macromolecules 26, 1293 (1993)mamobx0024-929710.1021/ma00058a016] provide an extremely useful framework for understanding the behavior of interacting, randomly branching polymers, the approach is inherently limited. here we use a combinat ...201728208462
neutral aggregation in finite-length genotype space.the advent of modern genome sequencing techniques allows for a more stringent test of the neutrality hypothesis of darwinian evolution, where all individuals have the same fitness. using the individual-based model of wright and fisher, we compute the amplitude of neutral aggregation in the genome space, i.e., the probability of finding two individuals at genetic (hamming) distance k as a function of the genome size l, population size n, and mutation probability per base ν. in well-mixed populati ...201728208412
magnetic resonance imaging evaluation of the effects of surgical invasiveness on paravertebral muscles after muscle-preserving interlaminar decompression (mild).this is a retrospective study.201728207618
weakly supervised patchnets: describing and aggregating local patches for scene recognition.traditional feature encoding scheme (e.g., fisher vector) with local descriptors (e.g., sift) and recent convolutional neural networks (cnns) are two classes of successful methods for image recognition. in this paper, we propose a hybrid representation, which leverages the discriminative capacity of cnns and the simplicity of descriptor encoding schema for image recognition, with a focus on scene recognition. to this end, we make three main contributions from the following aspects. first, we pro ...201728207394
using receiver operating characteristic curves to optimize discovery-based software with comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry.we report a quantitative approach to optimize implementation of discovery-based software for comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (gc × gc-tofms). the software performs a tile-based fisher ratio (f-ratio) analysis and facilitates a supervised nontargeted analysis based upon the experimental design to aid in the discovery of analytes with statistically different variances between sample classes. the quantitative approach for software optim ...201728207236
the barrow neurological institute scale revisited: predictive capabilities for cerebral infarction and clinical outcome in patients with aneurysmal subarachnoid hemorrhage.in 2012, a new computed tomography (ct) grading scale was introduced by the barrow neurological institute group ("bni scale") to predict angiographic and symptomatic vasospasm in aneurysmal subarachnoid hemorrhage.201728201763
calibration strategies for ft-ir and other isotope ratio infrared spectrometer instruments for accurate δ(13)c and δ(18)o measurements of co2 in air.this paper describes calibration strategies in laboratory conditions that can be applied to ensure accurate measurements of the isotopic composition of the co2 in ultradry air, expressed as δ(13)c and δ(18)o on the vpdb scale, with either ft-ir (in this case a vertex 70 v (bruker)) or an isotope ratio infrared spectrometer (iris) (in this case a delta ray (thermo fisher scientific)). in the case of ft-ir a novel methodology using only two standards of co2 in air with different mole fractions but ...201728199097
body composition in patients with crohn's disease and ulcerative colitis.the nutritional status of individuals with inflammatory bowel diseases is directly related to the severity of the disease and is associated with poor prognosis and the deterioration of immune competence.201728198913
convergence to travelling waves in fisher's population genetics model with a non-lipschitzian reaction term.we consider a one-dimensional population genetics model for the advance of an advantageous gene. the model is described by the semilinear fisher equation with unbalanced bistable non-lipschitzian nonlinearity f(u). the "nonsmoothness" of f allows for the appearance of travelling waves with a new, more realistic profile. we study existence, uniqueness, and long-time asymptotic behavior of the solutions u(x, t), [formula: see text]. we prove also the existence and uniqueness (up to a spatial shift ...201728197714
effect of a scalp cooling device on alopecia in women undergoing chemotherapy for breast cancer: the scalp randomized clinical trial.chemotherapy may induce alopecia. although scalp cooling devices have been used to prevent this alopecia, efficacy has not been assessed in a randomized clinical trial.201728196254
correlates of health literacy and its impact on illness beliefs for emergency department patients with acute heart failure.to study the relationship between health literacy (hl) and socioeconomic, demographic factors and disease-specific illness beliefs among patients who present to the emergency department with heart failure (hf).201728195940
neonatal resuscitation program rolling refresher: maintaining chest compression proficiency through the use of simulation-based education.structured training courses have shown to improve patient outcomes; however, guidelines are inconsistently applied in up to 50% of all neonatal resuscitations. this is partly due to the fact that psychomotor skills needed for resuscitation decay within 6 months to a year from the completion of a certification course. currently, there are no recommendations on how often refresher training should occur to prevent skill decay.201728195835
masculinity, work, and the fountain of youth: irving fisher and the life extension institute, 1914-31.in 1914, progressive era reformer irving fisher and wealthy contractor harold ley founded the life extension institute (lei), a business venture organized to address the problems of american health. for approximately two decades, from 1914 until the death of its medical director in 1931, the life extension institute widely promoted its health maintenance program of annual physical examinations and health literature. the advertised goal of the lei was to extend life without old age, as well as im ...199928195809
retreatability of two endodontic sealers, endosequence bc sealer and ah plus: a micro-computed tomographic comparison.recently, bioceramic sealers like endosequence bc sealer (bc sealer) have been introduced and are being used in endodontic practice. however, this sealer has limited research related to its retreatability. hence, the aim of this study was to evaluate the retreatability of two sealers, bc sealer as compared with ah plus using micro-computed tomographic (micro-ct) analysis.201728194360
a generalized fellner-schall method for smoothing parameter optimization with application to tweedie location, scale and shape models.we consider the optimization of smoothing parameters and variance components in models with a regular log likelihood subject to quadratic penalization of the model coefficients, via a generalization of the method of fellner (1986) and schall (1991). in particular: (i) we generalize the original method to the case of penalties that are linear in several smoothing parameters, thereby covering the important cases of tensor product and adaptive smoothers; (ii) we show why the method's steps increase ...201728192595
the stability of many-body systems.we apply the pair interaction stability criteria of fisher and ruelle (1966 j. math. phys. 7 260) to establish the range of thermodynamic stability for a number of simple analytic potential forms used for condensed matter theory and modelling in the literature. we identify the ranges of potential parameters where, for a given potential, the system is thermodynamically stable, unstable and of uncertain stability. this was further explored by carrying out molecular dynamics simulations on the doub ...200728192333
safety and efficacy of percutaneous microwave hepatic ablation near the heart.to evaluate safety and efficacy of percutaneous hepatic microwave (mw) ablation performed near the heart.201728190707
cervical spine imaging for young children with inflicted trauma: expanding the injury pattern.the purpose of this study was to document the incidence and pattern of cervical spine (c-spine) injuries in children below 36months with inflicted trauma.201728190553
maintenance of polygenic sex determination in a fluctuating environment: an individual-based model.r. a. fisher predicted that individuals should invest equally in offspring of both sexes, and that the proportion of males and females produced (the primary sex ratio) should evolve towards 1:1 when unconstrained. for many species, sex determination is dependent on sex chromosomes, creating a strong tendency for balanced sex ratios, but in other cases, multiple autosomal genes interact to determine sex. in such cases, the maintenance of multiple sex-determining alleles at multiple loci and the c ...201728187242
immunohistochemical detection of hematopoietic cell-specific protein-tyrosine phosphatase (tyrosine phosphatase shp-1) in a series of endometrioid and serous endometrial carcinoma.in this study, we evaluated the expression of shp-1 (ptpn6) in endometrioid (ec) and serous (sc) subtypes of endometrial carcinoma by immunohistochemical analysis. in total, 114 patients with ec carcinoma and 48 patients with sc carcinoma were enrolled in this study. the correlation between the type of histology, the grade of tumor, the stage of development, and immunoreactivity to shp-1 was evaluated. kaplan-meier and multivariate survival analyses, using a cox regression model, were performed ...201728187032
de novo upper extremity lymphedema after elective hand surgery in breast cancer survivors.the safety of elective hand surgery in breast cancer (bc) survivors is controversial because of concerns of developing upper extremity lymphedema. this study aimed to evaluate the risk of developing lymphedema after elective hand surgery among patients that underwent ipsilateral axillary lymph node dissection (alnd), sentinel lymph node biopsy (slnb), and/or radiation therapy (rt).201728187025
the value of diagnostic bilateral intracranial electroencephalography in treatment-resistant focal epilepsy.we assessed the efficacy and risks of diagnostic bilateral intracranial electroencephalography (biceeg) in patients with treatment-resistant epilepsy (tre) with poorly lateralized epileptogenic zone on noninvasive studies as reflected by progress to resection, engel outcome, and complication rate.201728185968
rapid documented growth of aneurysm bleb led to rupture of an incidental intracranial anterior communicating artery aneurysm.background a major challenge in the management of patients with unruptured intracranial aneurysms (uias) is to identify criteria indicating a higher risk of future uia rupture. we report a rare patient with documented short-term bleb growth of an uia followed by a fatal aneurysm rupture supporting the high risk of rupture of short-term shape changes in uias. case description a 72-year-old man with an incidental unruptured anterior communicating artery aneurysm of 9 mm showed a bleb growth on the ...201728183143
diffuse pulmonary ossification in fibrosing interstitial lung diseases: prevalence and associations.purpose to investigate the prevalence of diffuse pulmonary ossification (dpo) in patients with fibrosing interstitial lung disease (ild) and determine whether there are differences among the types of ilds. materials and methods institutional review board approval was given and patient consent was not required for this study. the study population comprised 892 consecutive patients with fibrosing ild, including 456 patients with idiopathic pulmonary fibrosis (ipf) (men, 366; women, 90; median age, ...201728182861
evaluation of thyroid nodules classified as bethesda category iii on fnac.the bethesda (bsrtc) category iii has been ascribed a malignancy rate of 5-15%, however, the probability of malignancy remains variable.201728182068
multiplexed transcriptome analysis to detect alk, ros1 and ret rearrangements in lung cancer.alk, ros1 and ret gene fusions are important predictive biomarkers for tyrosine kinase inhibitors in lung cancer. currently, the gold standard method for gene fusion detection is fluorescence in situ hybridization (fish) and while highly sensitive and specific, it is also labour intensive, subjective in analysis, and unable to screen a large numbers of gene fusions. recent developments in high-throughput transcriptome-based methods may provide a suitable alternative to fish as they are compatibl ...201728181564
an examination of disparities in pediatric pain management centered on socioeconomic factors and hospital characteristics.very little is known about pediatric pain management resource differences. in contrast, disparities in pain management within the adult population are known to exist. this research examined whether significant differences exist between hospitals in the state of new york and what factors impact these pain resources.201728181199
complications of open approaches to the skull base in the endoscopic era.objective it is important to characterize the developing complication profile of the open approach as it becomes reserved for more complex disease during the endoscopic era. our objective was to characterize complication rates of current open skull base surgery. design retrospective chart review. setting tertiary care center. participants the study group consisted of 103 patients and 117 open skull base surgeries were performed from 2008 to 2012. main outcome measures intraoperative/postoperativ ...201728180037
gravitational-wave data analysis. formalism and sample applications: the gaussian case.the article reviews the statistical theory of signal detection in application to analysis of deterministic gravitational-wave signals in the noise of a detector. statistical foundations for the theory of signal detection and parameter estimation are presented. several tools needed for both theoretical evaluation of the optimal data analysis methods and for their practical implementation are introduced. they include optimal signal-to-noise ratio, fisher matrix, false alarm and detection probabili ...201228179835
correction: to fish or not to fish: factors at multiple scales affecting artisanal fishers' readiness to exit a declining fishery.[this corrects the article doi: 10.1371/journal.pone.0031460.].201728178343
ct perfusion as an early biomarker of treatment efficacy in advanced ovarian cancer: an acrin and gog study.purpose: acrin 6695 was a feasibility study investigating whether ct perfusion (ctp) biomarkers are associated with progression-free survival (pfs) at 6 months (pfs-6) in patients with advanced ovarian cancer who were treated with carboplatin and either dose-dense (weekly) or conventional (3-weekly) paclitaxel, with optional bevacizumab in the prospective phase iii gog-0262 trial.experimental design: acrin 6695 recruited participants with residual disease after primary cytoreductive surgery or p ...201728174234
statistical inference in the wright-fisher model using allele frequency data.the wright–fisher model provides an elegant mathematical framework for understanding allele frequency data. in particular, the model can be used to infer the demographic history of species and identify loci under selection. a crucial quantity for inference under the wright–fisher model is the distribution of allele frequencies (daf). despite the apparent simplicity of the model, the calculation of the daf is challenging. we review and discuss strategies for approximating the daf, and how these a ...201728173553
bright spots of sustainable shark fishing.sharks, rays and chimeras (class chondrichthyes; herein 'sharks') today face possibly the largest crisis of their 420 million year history. tens of millions of sharks are caught and traded internationally each year, many populations are overfished to the point where global catch peaked in 2003, and a quarter of species have an elevated risk of extinction [1-3]. to some, the solution is to simply stop taking them from our oceans, or prohibit carriage, sale or trade in shark fins [4]. approaches s ...201728171764
[evaluation of a new information tool in an emergency department]aims : emergency departments represent unique and complex entities that must be understood by the public. objectives : to increase, by setting up screens, the number of information integrated by the patients during their waiting before medical care. method : cohort, before/after implementation of information screens, prospective, evaluative, monocentric study. patients were interviewed on the location of the hospital, the organization of the emergency department, their legal rights. the primary ...201628169817
are sawfishes still present in mozambique? a baseline ecological study.sawfishes (pristidae) were formerly abundant in the western indian ocean, but current data on sawfish presence and distribution are lacking for most of the region. this paper summarises historical records of sawfishes in mozambican waters and presents the findings of the first assessment of the presence and status of sawfishes in mozambique. a countrywide baseline assessment was undertaken between may and july 2014, using interviews with artisanal, semi-industrial and industrial fishers, fish tr ...201728168114
application of optimized large surface area date stone (phoenix dactylifera ) activated carbon for rhodamin b removal from aqueous solution: box-behnken design approach.box-behnken model of response surface methodology was used to study the effect of adsorption process parameters for rhodamine b (rhb) removal from aqueous solution through optimized large surface area date stone activated carbon. the set experiments with three input parameters such as time (10-600min), adsorbent dosage (0.5-10g/l) and temperature (25-50°c) were considered for statistical significance. the adequate relation was found between the input variables and response (removal percentage of ...201728167440
body mass index modifies the relationship between γ-h2ax, a dna damage biomarker, and pathological complete response in triple-negative breast cancer.body mass index (bmi) is largely investigated as a prognostic and predictive factor in triple-negative breast cancer (tnbc). overweight and obesity are linked to a variety of pathways regulating tumor-promoting functions, including the dna damage response (ddr). the ddr physiologically safeguards genome integrity but, in a neoplastic background, it is aberrantly engaged and protects cancer cells from chemotherapy. we herein verified the role of bmi on a previously assessed association between dd ...201728166748
design of experiments (doe) in pharmaceutical development.at the beginning of the twentieth century, sir ronald fisher introduced the concept of applying statistical analysis during the planning stages of research rather than at the end of experimentation. when statistical thinking is applied from the design phase, it enables to build quality into the product, by adopting deming's profound knowledge approach, comprising system thinking, variation understanding, theory of knowledge, and psychology. the pharmaceutical industry was late in adopting these ...201728166428
carbon dioxide washout during high flow nasal cannula versus nasal cpap support: an in vitro study.to compare co2 washout time at different levels of hfnc versus ncpap in a premature infant lung model with simulated mouth-closed and mouth-open conditions using two sizes of nasal cannula and full- and half-prong hfnc insertion depths.201728165671
effect of anesthesia-associated hypotension on neurologic outcome in dogs undergoing hemilaminectomy because of acute, severe thoracolumbar intervertebral disk herniation: 56 cases (2007-2013).objective to evaluate the effect of anesthesia-associated hypotension on final motor and urinary function in paraplegic dogs without nociception that underwent hemilaminectomy because of acute, severe thoracolumbar intervertebral disk herniation (ivdh). design retrospective case series. animals 56 paraplegic dogs with acute thoracolumbar ivdh and absent nociception. procedures medical records were reviewed, and signalment, history, anesthetic details, and results of serial neurologic assessments ...201728165305
pupillary involvement in miller fisher syndrome.miller fisher syndrome is characterised by the classical triad of ophthalmoplegia, ataxia, and areflexia. ophthalmoparesis without ataxia, without areflexia, or with neither have been attributed as atypical forms of mfs. we report two patients with mfs who had tonic pupils and raised anti-gq1b antibody titres. bilateral dilated pupils (either tonic or fixed) can be a manifestation of mfs and anti-gq1b immunoglobulin g (igg) antibodies are useful to confirm the diagnosis in unexplained cases. the ...201328163765
gravitational-wave data analysis. formalism and sample applications: the gaussian case.the article reviews the statistical theory of signal detection in application to analysis of deterministic gravitational-wave signals in the noise of a detector. statistical foundations for the theory of signal detection and parameter estimation are presented. several tools needed for both theoretical evaluation of the optimal data analysis methods and for their practical implementation are introduced. they include optimal signal-to-noise ratio, fisher matrix, false alarm and detection probabili ...200528163647
evaluation of the qiagen 140-snp forensic identification multiplex for massively parallel sequencing.a new forensic 140-snp genotyping system from qiagen, designed for massively parallel sequencing (mps) analysis, was evaluated using the ion pgm™ mps system. assessments consisted of the sequencing of: established control dnas that had been previously genotyped with alternative pcr and library preparation kits supplied by thermo fisher scientific for the ion pgm™ system; a simple set of artificial dna mixtures; dna extracted from a degraded femur; and a dilution series to gauge forensic sensitiv ...201728160618
gene selection for microarray cancer classification using a new evolutionary method employing artificial intelligence concepts.gene selection is a demanding task for microarray data analysis. the diverse complexity of different cancers makes this issue still challenging. in this study, a novel evolutionary method based on genetic algorithms and artificial intelligence is proposed to identify predictive genes for cancer classification. a filter method was first applied to reduce the dimensionality of feature space followed by employing an integer-coded genetic algorithm with dynamic-length genotype, intelligent parameter ...201728159597
patients' esthetic expectations and satisfaction with complete dentures.understanding the factors affecting patients' satisfaction with their dentures is essential to achieving higher satisfaction rates.201728159342
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