Publications

biological transmission of arboviruses: reexamination of and new insights into components, mechanisms, and unique traits as well as their evolutionary trends.	among animal viruses, arboviruses are unique in that they depend on arthropod vectors for transmission. field research and laboratory investigations related to the three components of this unique mode of transmission, virus, vector, and vertebrate host, have produced an enormous amount of valuable information that may be found in numerous publications. however, despite many reviews on specific viruses, diseases, or interests, a systematic approach to organizing the available information on all f ...	0	16223950
flavidb: a data mining system for knowledge discovery in flaviviruses with direct applications in immunology and vaccinology.	the flavivirus genus is unusually large, comprising more than 70 species, of which more than half are known human pathogens. it includes a set of clinically relevant infectious agents such as dengue, west nile, yellow fever, and japanese encephalitis viruses. although these pathogens have been studied extensively, safe and efficient vaccines lack for the majority of the flaviviruses.	0	25544857
"sokuluk" virus, a new group b arbovirus isolated from vespertilio pipistrellus schreber, 1775, bat in the kirghiz s.s.r.		1973	4727779
genetic characterization of yokose virus, a flavivirus isolated from the bat in japan.	yokose virus (strain oita-36) was isolated from the bat in japan in 1971. in the present study, we determined complete nucleotide sequences of yokose virus using rt-pcr and race techniques. yokose virus genome consists of 10,857 nucleotides in length (accession no. ab114858), containing a single open reading frame (3425 amino acids) encoding 11 viral proteins. we deduced the boundaries of each protein in the polyprotein sequence according to the protein cleavage sites of other flaviviruses. the ...	2005	15661139
bats: important reservoir hosts of emerging viruses.	bats (order chiroptera, suborders megachiroptera ["flying foxes"] and microchiroptera) are abundant, diverse, and geographically widespread. these mammals provide us with resources, but their importance is minimized and many of their populations and species are at risk, even threatened or endangered. some of their characteristics (food choices, colonial or solitary nature, population structure, ability to fly, seasonal migration and daily movement patterns, torpor and hibernation, life span, roo ...	2006	16847084
universal primers that amplify rna from all three flavivirus subgroups.	species within the flavivirus genus pose public health problems around the world. increasing cases of dengue and japanese encephalitis virus in asia, frequent outbreaks of yellow fever virus in africa and south america, and the ongoing spread of west nile virus throughout the americas, show the geographical burden of flavivirus diseases. flavivirus infections are often indistinct from and confused with other febrile illnesses. here we review the specificity of published primers, and describe a n ...	2008	18218114
characterization of a novel flavivirus from mosquitoes in northern europe that is related to mosquito-borne flaviviruses of the tropics.	a novel flavivirus was isolated from mosquitoes in finland, representing the first mosquito-borne flavivirus from northern europe. the isolate, designated lammi virus (lamv), was antigenically cross-reactive with other flaviviruses and exhibited typical flavivirus morphology as determined by electron microscopy. the genomic sequence of lamv was highly divergent from the recognized flaviviruses, and yet the polyprotein properties resembled those of mosquito-borne flaviviruses. phylogenetic analys ...	2009	19570865
structure and functionality in flavivirus ns-proteins: perspectives for drug design.	flaviviridae are small enveloped viruses hosting a positive-sense single-stranded rna genome. besides yellow fever virus, a landmark case in the history of virology, members of the flavivirus genus, such as west nile virus and dengue virus, are increasingly gaining attention due to their re-emergence and incidence in different areas of the world. additional environmental and demographic considerations suggest that novel or known flaviviruses will continue to emerge in the future. nevertheless, u ...	2010	19945487
spatial disaggregation of tick occurrence and ecology at a local scale as a preliminary step for spatial surveillance of tick-borne diseases: general framework and health implications in belgium.	the incidence of tick-borne diseases is increasing in europe. sub national information on tick distribution, ecology and vector status is often lacking. however, precise location of infection risk can lead to better targeted prevention measures, surveillance and control.	2013	23800283
bed bugs and infectious disease: a case for the arboviruses.		2013	23966852
ecuador paraiso escondido virus, a new flavivirus isolated from new world sand flies in ecuador, is the first representative of a novel clade in the genus flavivirus.	a new flavivirus, ecuador paraiso escondido virus (epev), named after the village where it was discovered, was isolated from sand flies (psathyromyia abonnenci, formerly lutzomyia abonnenci) that are unique to the new world. this represents the first sand fly-borne flavivirus identified in the new world. epev exhibited a typical flavivirus genome organization. nevertheless, the maximum pairwise amino acid sequence identity with currently recognized flaviviruses was 52.8%. phylogenetic analysis o ...	2015	26355096
new insights into flavivirus evolution, taxonomy and biogeographic history, extended by analysis of canonical and alternative coding sequences.	to generate the most diverse phylogenetic dataset for the flaviviruses to date, we determined the genomic sequences and phylogenetic relationships of 14 flaviviruses, of which 10 are primarily associated with culex spp. mosquitoes. we analyze these data, in conjunction with a comprehensive collection of flavivirus genomes, to characterize flavivirus evolutionary and biogeographic history in unprecedented detail and breadth. based on the presumed introduction of yellow fever virus into the americ ...	2015	25719412
detection of entebbe bat virus after 54 years.	entebbe bat virus (entv; flaviviridae: flavivirus), closely related to yellow fever virus, was first isolated from a little free-tailed bat (chaerephon pumilus) in uganda in 1957, but was not detected after that initial isolation. in 2011, we isolated entv from a little free-tailed bat captured from the attic of a house near where it had originally been found. infectious virus was recovered from the spleen and lung, and the viral rna was sequenced and compared with that of the original isolate. ...	2015	26101270
[taxonomy of the sokuluk virus (sokv) (flaviviridae, flavivirus, entebbe bat virus group) isolated from bats (vespertilio pipistrellus schreber, 1774), ticks (argasidae koch, 1844), and birds in kyrgyzstan].	complete genome sequencing of the sokuluk virus (sokv) isolated in kyrgyzstan from bats vespertilio pipistrellus and their obligatory parasites--argasidae koch, 1844, ticks was carried out. sokv was classified as attributed to the flaviviridae family, flavivirus genus. the maximum homology (71% for nucleotide and 79% for amino acid sequences) was detected with respect to the entebbe bat virus (entv). entv and sokv form a group joining to the yellow fever virus (yfv) within the limits of the mosq ...	2016	25065143
a review of flaviviruses that have no known arthropod vector.	most viruses in the genus flavivirus are horizontally transmitted between hematophagous arthropods and vertebrate hosts, but some are maintained in arthropod- or vertebrate-restricted transmission cycles. flaviviruses maintained by vertebrate-only transmission are commonly referred to as no known vector (nkv) flaviviruses. fourteen species and two subtypes of nkv flaviviruses are recognized by the international committee on taxonomy of viruses (ictv), and tamana bat virus potentially belongs to ...	2017	28635667