| once-weekly fluconazole in children with tinea capitis due to microsporum canis. | | 2005 | 15868642 |
| repetitive-sequence-pcr-based dna fingerprinting using the diversilab system for identification of commonly encountered dermatophytes. | the performance of repetitive-sequence-based pcr (rep-pcr) using the diversilab system for identification of dermatophytes commonly isolated in a clinical laboratory was assessed by comparing results to those of conventional tests (colony morphology, microscopic examination of slide cultures, and, for suspected trichophyton species, use of additional media). sixty-one cultures were tested in phase 1, the feasibility portion of the study; 64 additional cultures were tested in phase 2, the validat ... | 2005 | 15872233 |
| antifungal activities of six south african terminalia species (combretaceae). | a serial microplate dilution method developed for bacteria was modified slightly and gave good results with several fungi. the antifungal activity of acetone, hexane, dichloromethane and methanol leaf extracts of six terminalia species (terminalia prunioides, terminalia brachystemma, terminalia sericea, terminalia gazensis, terminalia mollis and terminalia sambesiaca) were tested against five fungal animal pathogens (candida albicans, cryptococcus neoformans, aspergillus fumigatus, microsporum c ... | 2005 | 15894142 |
| organometallic-based antibacterial and antifungal compounds: transition metal complexes of 1,1'-diacetylferrocene-derived thiocarbohydrazone, carbohydrazone, thiosemicarbazone and semicarbazone. | organometallic-based, 1,1'-diacetylferrocene-derived antibacterial and antifungal thiocarbohydrazone, carbohydrazone, thiosemicarbazone and semicarbazone have been prepared by condensing equimolar amount of 1,1'-diacetylferrocene with thiocarbohydrazide, carbohydrazide thiosemicarbazide and semicarbazide, respectively. these were used as ligands for the preparation of their cobalt (ii), copper (ii), nickel (ii) and zinc (ii) metal complexes. all the synthesized ligands and their complexes were c ... | 2005 | 15895689 |
| therapeutic options for the treatment of tinea capitis: griseofulvin versus fluconazole. | tinea capitis is a relatively common fungal infection of childhood. griseofulvin has been the mainstay of treatment for many years. however, newer oral antifungal agents are being used more frequently. | 2005 | 15897167 |
| antidermatophyte activity of ether extract of nigella sativa and its active principle, thymoquinone. | the antifungal activity of ether extract of nigella sativa seed and its active principle thymoquinone was tested against eight species of dermatophytes: four species of trichophyton rubrum and one each of trichophyton interdigitale, trichophyton mentagrophytes, epidermophyton floccosum and microsporum canis. agar diffusion method with serial dilutions of ether extract of nigella sativa, thymoquinone and griseofulvin was employed. the incubation was carried out at 30 degrees c for 14 days. the di ... | 2005 | 15908151 |
| fluconazole upregulates sconc expression and inhibits sulphur metabolism in microsporum canis. | azole derivatives such as fluconazole are the mainstay of therapeutic agents for the treatment of fungal infections. their mode of action involving alteration in the conversion of lanosterol to ergosterol is well established. here we report the effect of fluconazole on the sulphur metabolism negative regulator gene (sconc) in microsporum canis. characterization of the m. canis sconc gene revealed that its orf is comprised of 495bp interrupted by four introns of 47-70bp. exposure of m. canis in s ... | 2005 | 15922636 |
| [incidence, immunity and treatment of feline dermatophytosis]. | feline dermatophytosis is a superficial skin infection characterized by the invasion of cornified tissues such as hair and nails. this infection is nearly always caused by microsporum canis. infected animals release infective spores in the environment which will then contaminate other animals or humans. infected animals usually develop immunity so the infection will spontaneously disappear after a few weeks to months. long haired and immunocom-promised cats do not have the same ability to acquir ... | 2005 | 15929601 |
| [evaluation the antimycotic activity of itraconazole in human stratum corneum with vitro fungi cultivation]. | to establish a new model to evaluate the antifungal activity of antimycotics. | 2005 | 15949332 |
| in-vitro antibacterial, antifungal and cytotoxic properties of sulfonamide--derived schiff's bases and their metal complexes. | a series of new antibacterial and antifungal schiff's bases derived from sulfonamides, as well as their transition metal complexes incorporating cobalt (ii), copper (ii), nickel (ii) and zinc (ii) were synthesized, characterized and screened for their in-vitro antibacterial activity against six gram-negative (escherichia coli, klebsiella pneumoniae, proteus mirabilis, pseudomonas aeruginosa, salmonella typhi and shigella dysentriae) and four gram-positive (bacillus cereus, corynebacterium diphth ... | 2005 | 15968823 |
| inter-single-sequence-repeat-pcr typing as a new tool for identification of microsporum canis strains. | microsporum canis is a ubiquitous dermatophyte that commonly causes human infections. since contact with infected animals is the usual way of infection, tracing its source is an essential preventive measure. | 2005 | 15978415 |
| evaluation of antimicrobial activities of several mannich bases and their derivatives. | the aim of this study was to evaluate the antimicrobial activities of several mannich bases and their derivatives against pathogenic bacteria and fungi. 3-dimethylamino-1-phenyl-1-propanone hydrochloride (ig1) as mono-mannich base, bis(beta-aroylethyl)methylamine hydrochlorides (b1, b5) as bis-mannich bases, 3-aroyl-4-aryl-1-methyl-4-piperidinol hydrochlorides (c1, c5) as piperidinol derivatives, which are structural isomers of bis-mannich bases, n,n'-bis(3-dimethylamino-1-phenylpropylidene)hydr ... | 2005 | 15981301 |
| antifungal susceptibilities of dermatophytic agents isolated from clinical specimens. | the aim of this study was to investigate the susceptibility to four antifungal agents: ketoconazole, terbinafine, itraconazole and fluconazole, of the different species of dermatophyte strains isolated from clinical specimens. a total of 128 specimens were collected from toe nail, foot, inguinal region, trunk, hands and head. the dermatophytes tested included trichophyton rubrum 108 (84.4%), trichophyton mentagrophytes 11 (8.6%), epidermophyton floccosum 5 (3.9%), microsporum canis 2 (1.5%) and ... | 2005 | 16048753 |
| dermatophytes growth curve and in vitro susceptibility test: a broth micro-titration method. | the introduction of systemic antifungal drugs which act upon different targets is the main issue of the in vivo antifungal resistance control. different factors, such as growth curve phase, quality of the specimen, quantity of the inoculum, temperature, ph, culture medium composition, incubation duration and solvent, are believed important factors affecting minimum inhibitory concentration (mic) value to most of the antifungal agents. we assayed an in vitro susceptibility test with 40 isolates o ... | 2005 | 16110777 |
| seasonal 4-year investigation into the role of the alpine marmot (marmota marmota) as a carrier of zoophilic dermatophytes. | two hundred and six samples of alpine marmot (mamota marmota) hair (148 from adults and 58 from young subjects), 102 soil samples from the entrances to the burrows of the above individuals and 20 control specimens (obtained from adjoining areas away from the burrow systems where the rodents are not usually present) were examined from may 1994 to september 1997. seventy-five isolates belonging to six species of dermatophytes were found in 69 of the 206 hair samples examined (33.5%). two species w ... | 2005 | 16110784 |
| eighty-four consecutive cases of tinea faciei in siena, a retrospective study (1989-2003). | consecutive cases of tinea faciei diagnosed in siena between 1989 and 2003 were studied retrospectively for differences in clinical form, demographic data and species of dermatophyte isolated. the series consisted of 84 cases (59 females, 25 males) with a mean age of 27 years. mean age of females (32.4 years) was significantly greater than that of males (14.2 years). the dermatophytes most frequently isolated were microsporum canis (38 cases) and trichophyton rubrum (31 cases). clinical form was ... | 2005 | 16115106 |
| metalloprotease gene of arthroderma gypseum. | the full-length cdna sequence for metalloprotease (mep) of arthroderma gypseum (one of the teleomorphs of the microsporum gypseum complex) was determined by the 5'-rapid amplification of cdna ends (race) and 3'-race methods using cdna as a template. the full-length cdna sequence of the mep (2,670 bp) gene was proved to encode 677 amino acids. the amino acid sequence of the a. gypseum mep gene shared about 89 and 66% sequence similarity with the conserved region of the microsporum canis mep gene ... | 2005 | 16116253 |
| antifungal susceptibility and genotypical pattern of microsporum canis strains. | dermatophytes are a group of fungi that are capable of invading keratinized tissues of humans and other animals. antifungal susceptibility analysis and genetic studies by random amplification of polymorphic dna (rapd), have been used to detect polymorphism as well as determining the possible resistance of dermatophytes to antifungals. the aim of this study was to evaluate the possible correlation between the antifungal susceptibility and genotypical pattern of microsporum canis strains isolated ... | 2005 | 16121230 |
| [enzyme activities of dermatophytes isolated from different clinical samples by apizym method]. | dermatophytes' enzymes may have a role in chronic superficial infections. in this study it was planned to investigate the possible relationship between the enzymatic activities of the dermatophytes and acute or chronic course of the infections. dermatophytes were isolated from 58 (72%) out of 81 patients with superficial infections. the infections were divided into two groups as acute (< or = 6 weeks) or chronic (> 6 weeks). isolated fungi were identified by the classical methods and apizym meth ... | 2005 | 16128029 |
| lung cancer in asian women-the environment and genes. | the mortality rate of lung cancer in asian women has increased significantly in the past few decades. environmental factors include tobacco smoke (active and environmental), other indoor pollutions (cooking oil vapours, coal burning, fungus spores), diet, and infections. active tobacco smoking is not the major factor. the relative risk of lung cancer among non-smoking women ever exposed to environmental smoke from their husbands was 1.20 from a meta-analysis. cooking oil vapours associated with ... | 2005 | 16135162 |
| phenotypical and molecular characterization of microsporum canis strains in north-east brazil. | this study investigated the possible correlation between the phenotypical and genotypical characteristics of microsporum canis isolated from cats and dogs in north-east brazil. | 2005 | 16162228 |
| survey of dermatophytes on clinically normal cats in the southeast of england. | to report the incidence of dermatophytes on the hair coat of asymptomatic cats in the southeast of england. asymptomatic cats are often blamed for transmission of dermatophytes between animals and humans. this study may help to clarify whether cats are responsible for the increase in fungal infections among the human population. | 2005 | 16167594 |
| chemical composition and antidermatophytic properties of volatile fractions of hexanic extract from leaves of cupressus lusitanica mill. from cameroon. | the chemical composition of five column fractions of hexanic leaf extract of cupressus lusitanica were analysed by gas chromatography and gas chromatography-mass spectrometry and then tested for their antidermatophytic activities using the agar dilution method. the first fraction (f(1)) has only hydrocabon monoterpenes with alpha-pinene (80.0%) as major component. the main constituents of the second fraction (f(2)) were epi-bicyclosesquiphellandrene (35.3%), epi-zonarene (10.3%), 1s, cis-calamen ... | 2006 | 16169171 |
| in-vitro antibacterial, antifungal and cytotoxic activities of some coumarins and their metal complexes. | a series of new antibacterial and antifungal coumarin-derived compounds and their transition metal complexes [cobalt (ii), copper (ii), nickel (ii) and zinc (ii)] have been synthesized, characterized and screened for their in vitro antibacterial activity against escherichia coli, klebsiella pneumoniae, proteus mirabilis, pseudomonas aeruginosa, salmonella typhi, shigella dysenteriae, bacillus cereus, corynebacterium diphtheriae, staphylococcus aureus and streptococcus pyogenes bacterial strains ... | 2005 | 16206827 |
| inhibition of the growth in vitro of trichophyton mentagrophytes, trichophyton erinacei and microsporum persicolor by miconazole and chlorhexidine. | an agar dilution technique was used to assess the minimum inhibitory concentrations (mics) of miconazole, chlorhexidine and a 1:1 combination of both agents for 9 isolates of trichophyton mentagrophytes, 9 isolates of trichophyton erinacei and 5 isolates of microsporum persicolor. mics of chlorhexidine did not vary significantly between the three dermatophyte species tested, but the mics of miconazole alone and in combination with chlorhexidine for t. erinacei were significantly greater that tho ... | 2005 | 16238813 |
| activity of the triazole antifungal r126638 as assessed by corneofungimetry. | r126638 is a novel triazole exhibiting potent in vitro and in vivo antifungal activity against fungal pathogens including dermatophytes and yeasts. | 2006 | 16247249 |
| tinea faciei in a goat handler due to microsporum canis. | | 2005 | 16309360 |
| reproducible genetic transformation system for two dermatophytes, microsporum canis and trichophyton mentagrophytes. | a reproducible genetic transformation system was developed for two major dermatophytes, microsporum canis and trichophyton mentagrophytes. two circular transformation vectors carrying either the bacterial hygromycin b phosphotransferase gene (hph) or both the hph and green fluorescent protein (egfp) genes under the control of a promoter sequence from cochlibolus heterostrophus were introduced independently into the protoplasts by a polyethylene glycol (peg)-mediated method. polymerase chain reac ... | 2005 | 16320496 |
| effect of a killer toxin of yeast on eucaryotic systems. | the saccharomyces cerevisiae killer toxin kt 28, which inhibits sensitive yeasts, was shown to have no effect on several pathogenic fungi or on the protozoan trichomonas vaginalis. at concentrations of about 0.1 mg/ml, a partial inhibition of the skin pathogenic fungi trichophyton rubrum and microsporum canis was observed at ph 6.5. no pharmacological activity was detected in various tests with several animal organs. | 1988 | 16347605 |
| aetiological agents of tinea capitis in tehran (iran). | a total of 1568 patients with suspected tinea capitis were examined for causative fungal agents between 1994 and 2001. laboratory examination confirmed tinea capitis in 209 patients. males were affected more frequently (67.5%) than females (32.5%) and in both sexes, those who were 3-11 years old, were more infected. trichophyton violaceum was the most common aetiological agent (37.3%) followed by trichophyton schoenleinii (21.5%), microsporum canis (18.6%), trichophyton verrocosum (14.8%), trich ... | 2006 | 16367822 |
| antifungal activity of fluid extract and essential oil from anise fruits (pimpinella anisum l., apiaceae). | antifungal activities of fluid extract and essential oil obtained from anise fruits pimpinella anisum l. (apiaceae) were tested in vitro on clinical isolates of seven species of yeasts and four species of dermatophytes. diffusion method with cylinders and the broth dilution method were used for antifungal activity testing. anise fluid extract showed antimycotic activity against candida albicans, c. parapsilosis, c. tropicalis, c. pseudotropicalis and c. krusei with mic values between 17 and 20% ... | 2005 | 16375827 |
| anti-fungal activity of crude extracts and essential oil of moringa oleifera lam. | investigations were carried out to evaluate the therapeutic properties of the seeds and leaves of moringa oleifera lam as herbal medicines. ethanol extracts showed anti-fungal activities in vitro against dermatophytes such as trichophyton rubrum, trichophyton mentagrophytes, epidermophyton floccosum, and microsporum canis. gc-ms analysis of the chemical composition of the essential oil from leaves showed a total of 44 compounds. isolated extracts could be of use for the future development of ant ... | 2007 | 16406607 |
| evaluation of fungicidal efficacy of benzalkonium chloride (steramina g u.v.) and virkon-s against microsporum canis for environmental disinfection. | the aim of this study is to evaluate the antifungal efficacy of steramina g u.v. (10% solution of alkyldimetylbenzylammonium chloride; formenti grünenthal) and virkon-s (multipurpose system; antec international) against microsporum canis-infected hairs and spores. samples were collected from a random sample of household cats and from subjects from catteries. seventy m. canis-positive hairbrushes containing furs, keratin scales and other organic material were treated with each of the two disinfec ... | 2006 | 16437301 |
| is itraconazole the treatment of choice in microsporum canis tinea capitis? | mycotic scalp infection caused by microsporum canis is the most dominant cause of tinea capitis in greece. griseofulvin has been the gold standard for the treatment of tinea capitis, but it is unavailable in our country. in this study, we evaluated 111 children with m. canis tinea capitis that were treated with itraconazole. eighty-one of them were treated with itraconazole capsule pulse therapy (group a) and 30 (group b) were treated with oral suspension administered in continuous regimen. twen ... | 2005 | 16444907 |
| tinea capitis in eastern nepal. | tinea capitis is an increasing public health concern throughout the world. the clinical types and etiological agents vary from time to time and place to place. this study was undertaken to identify the etiological agents and to determine the clinico-etiological correlation of tinea capitis in eastern nepal. | 2006 | 16445495 |
| [statistical study of dermatomycosis - observations in sendai national hospital over a 30 year period]. | a statistical 30-year study of dermatomycosis in sendai national hospital (1968-1997) revealed many changes in the prevalent diseases: tinea pedis and tinea unguium constantly increased during this period, and the ratio of the former associated with nail infection finally reached 30% of all tinea pedis patients. on the contrary, tinea corporis and cruris showed a remarkable decreasing tendency. patient age distribution of each disease also showed distinctive changes, generally increasing in the ... | 2006 | 16465134 |
| [new studies on the characterization of virulence factors in microsporum canis]. | microsporum canis is a worldwide distributed zoophilic and zoonotic dermatophyte which is responsible for most cases of feline ringworm. its prevalence is on the rise in developed countries. since 1995, the author and his laboratory have developed a research programme to better understand the pathogenesis of m. canis dermatophytosis. both the potential fungal virulence factors and the host immune response were investigated. a 31.5 kda keratinolytic subtilase (sub) and a 43.5 kda keratinolytic me ... | 2005 | 16465781 |
| [dermatophytic disease in a tunisian family]. | dermatophytic disease is a rare chronic infection caused by common dermatophytes and characterized by cutaneous and subcutaneous invasion. it is observed mainly in north africa where it is presumably inherited via an autosomal recessive trait. cellular immunodeficiency could account for the chronic nature of the disease and for its refractoriness to drug treatment. the purpose of this report is to describe the occurrence of dermatophytic disease in three sisters of consanguineous parents in a ru ... | 2005 | 16465820 |
| dermatophytoses in monterrey, méxico. | in the present report we reviewed a total of 2397 cases of dermatophytosis from superficial cutaneous lesions between the years 1978 and 1990. the cases included were from the department of dermatology at the university hospital located in the city of monterrey, méxico. a total of 726 tinea pedis, 613 tinea unguium, 441 tinea capitis, 395 tinea corporis and 222 tinea cruris cases were observed. the most commonly isolated dermatophyte species was trichophyton rubrum (45%), followed by trichophyto ... | 2006 | 16466445 |
| prevalence of zoonotic agents in dogs visiting hospitalized people in ontario: implications for infection control. | visitation of hospitalized people by dogs is becoming commonplace, but little is known about the potential health risks of introducing dogs to healthcare settings. this cross-sectional study evaluated the prevalence of zoonotic agents in a group of 102 visitation dogs from a variety of sources across ontario. between may and july 2004, owners were interviewed by a standardized questionnaire while dogs underwent a standardized physical examination. one specimen of faeces, hair-coat brushings and ... | 2006 | 16466831 |
| an evaluation of the clinical, cytological, infectious and histopathological features of feline acne. | clinical, cytological, microbial and histopathological features of feline acne were investigated in 22 cats referred or volunteered to a veterinary dermatology practice in the south-west region of the usa. for comparison, same parameters were evaluated in five unaffected pet cats. additionally, all cats were evaluated by immunohistochemistry (ihc) for the presence of feline calicivirus (fcv) and feline herpes virus (fhv-1) in acne lesions. the age of onset of acne in affected cats ranged from 6 ... | 2006 | 16515656 |
| kerion and dermatophytic granuloma. mycological and histopathological findings in 19 children with inflammatory tinea capitis of the scalp. | inflammatory tinea capitis or kerion is the result of a hypersensitivity reaction to a dermatophytic infection. majocchi's granuloma, in contrast, usually begins as a suppurative folliculitis and culminates in a granulomatous reaction. | 2006 | 16533218 |
| [tinea capitis in department of dermatology and venerology in the university hospital of donka at conakry, guinea]. | the authors report the results of a study carried out on tinea capitis, in the department of dermatology and venerology at the university hospital of donka in conakry, during one year in this department, the tinea capitis represents 3.2% of the consultations and remains the second mycosis. out of 414 consulted children, a male predominance of 75% was noted especially regarding the trichophytic tinea. school children aged of 6-14 years old are the most affected by the disease. the trichophytic ti ... | 2006 | 16568680 |
| oxovanadium(iv) complexes of hydrazides: potential antifungal agents. | oxovanadium(iv) -derived antifungals have been prepared by condensing equimolar amounts of vanadyl sulfate with hydrazides. all the synthesized ligands and their metal complexes were characterized by ir, uv-visible and micro analytical data. these synthesized compounds were screened for their antifungal activity against aspergillus flavus (a. flavus), trichophyton longifusus (t. longifusus), candida albicans (c. albicans), microsporum canis (m. canis), fusarium solani (f. solani) and candida gla ... | 2006 | 16570503 |
| in vitro antibacterial, antifungal & cytotoxic activity of some isonicotinoylhydrazide schiff's bases and their cobalt (ii), copper (ii), nickel (ii) and zinc (ii) complexes. | isonicotinoylhydrazide schiff's bases formed by the reaction of substituted and unsubstituted furyl-2-carboxaldehyde and thiophene-2-carboxaldehyde with isoniazid and, their co (ii), cu (ii), ni (ii) and zn (ii) complexes have been synthesized, characterized and screened for their in vitro antibacterial activity against mycobacterium tuberculosis, escherichia coli, klebsiella pneumoniae, proteus mirabilis, pseudomonas aeruginosa, salmonella typhi, shigella dysenteriae, bacillus cereus, corynebac ... | 2006 | 16570512 |
| synthesis and evaluation of antimicrobial and anticonvulsant activities of some new 3-[2- (5-aryl-1,3,4-oxadiazol-2-yl/4-carbethoxymethylthiazol-2-yl) imino-4-thiazolidinon-5-ylidene]-5-substituted/nonsubstituted 1h-indole-2-ones and investigation of their structure-activity relationships. | in the present study, 20 new compounds having 3-[2-(5-aryl-1,3,4-oxadiazol-2-yl) imino-4-thiazolidinon-5-ylidene]-5-substituted/nonsubstituted 1h-indole-2-one (i-xii) and 3-[2-(4-carbethoxymethylthiazol-2-yl)imino-4-thiazoldinon-5-ylidenel-5-substituted/nonsubstituted ih-indole-2-one (xiii-xx) systems were synthesized. the structures were confirmed by spectral methods (uv, ir, 1h-nmr, 13c-nmr, 13c-dept (135), electron impact mass spectrometry) and elemental analysis. all compounds were tested fo ... | 2006 | 16618017 |
| [a new bioassay model of antibiotic susceptibility by corneofungimetry]. | to study the value of a new bioassay model of antibiotic susceptibility by corneofungimetry which is more similar to human internal environment. | 2006 | 16677528 |
| isolation, characterization, and disruption of dnr1, the area/nit-2-like nitrogen regulatory gene of the zoophilic dermatophyte, microsporum canis. | a homolog of the major nitrogen regulatory genes area from aspergillus nidulans and nit-2 from neurospora crassa was isolated from the zoophilic dermatophyte, microsporum canis. this gene, dnr1, encodes a polypeptide of 761 amino acid residues containing a single zinc-finger dna-binding domain, which is almost identical in amino acid sequence to the zinc-finger domains of area and nit-2. the functional equivalence of dnr1 to area was demonstrated by complementation of an area loss-of-function mu ... | 2006 | 16702104 |
| unify qsar approach to antimicrobials. part 1: predicting antifungal activity against different species. | most of up-to-date reported molecular descriptors encode only information about the molecular structure. in previous papers, we have extended stochastic descriptors to encode additional information such as target site, partition system, or biological species [bioorg. med. chem. lett.2005, 15, 551; bioorg. med. chem. 2005, 13, 1119]. this work develops an unify markov model to describe with a single linear equation the biological activity of 74 drugs tested in the literature against some of the f ... | 2006 | 16759868 |
| epidemiology of tinea capitis in ceyhan district, adana in cukurova region, turkey. | this study was conducted on the primary school students in ceyhan district of adana, turkey between may and june 2002 to determine the clinical form, causative agents and prevalence of tinea capitis. a total of 9576 students, with a male-to-female ratio of 50.6-49.4% were screened in 24 primary schools. tinea capitis superficialis was diagnosed in seven cases, and kerion celsi in one. among eight cases, there were seven boys and one girl. trichophyton violaceum was the most frequent causative ag ... | 2006 | 16784454 |
| antimicrobial activity of indigofera suffruticosa. | various organic and aqueous extracts of leaves of indigofera suffruticosa mill (fabaceae) obtained by infusion and maceration were screened for their antibacterial and antifungal activities. the extracts were tested against 5 different species of human pathogenic bacteria and 17 fungal strains by the agar-solid diffusion method. most of the extracts were devoid of antifungal and antibacterial activities, except the aqueous extract of leaves of i. suffruticosa obtained by infusion, which showed s ... | 2006 | 16786057 |
| antibacterial, antifungal and cytotoxic properties of some sulfonamide-derived chromones. | a series of antibacterial and antifungal sulfonamide (sulfanilamide, sulfaguanidine, sulfamethaxozole, 4-aminoethylbenzene-sulfonamide and 4-amino-6-trifluoromethyl-benzene-1,3-disulfonamide) derived chromones, previously reported as inhibitors of carbonic anhydrase, have been screened for in-vitro antibacterial activity against four gram-negative (escherichia coli, pseudomonas aeruginosa, salmonella typhi and shigella flexener) and two gram-positive (bacillus subtilis and staphylococcus aureus) ... | 2006 | 16789431 |
| synthesis and biological evaluation of isomeric derivatives of naturally occurring spatozoate. | an isomer of the natural phthalate ester spatozoate (1), n-butyl 2-benzoyloxymethylbenzoate (2a) and a series of its new derivatives 2b-2s were synthesized and exposed to selected biological screening, as phthalates were reported to possess different biological activities. compound 2g was found to be the most potent cytotoxic agent with a ld50 = 8.98 microg/ml. in a bactericidal assay the compounds showed a broad spectrum of activities. compound 2a has a very promising fungicidal activity agains ... | 2006 | 16821646 |
| [etiologic and epidemiologic study of dermatomycoses in navarra (spain)]. | we review the etiology of the dermatophytosis in navarra (spain) over a 5-year period and it is compared with previous studies. we have isolated 312 strains of dermatophyte fungi in 285 patients (188 men and 97 women). trichophyton rubrum was the most frequently isolated species (58.6%) followed by trichophyton mentagrophytes (26.2%) and microsporum canis (10.5%). concerning the location of the lesions, tinea pedis was the clinical pattern found in the greatest number of patients, followed by ti ... | 1997 | 16854174 |
| a twenty-year survey of dermatophytoses in braga, portugal. | modifications in social habits together with the increase of emigration have contributed not only to increased dermatophytoses but also to an altered etiology. during the last few years, braga has suffered a radical change from a rural to a cosmopolitan life-style. | 2006 | 16863519 |
| mycetes and urban areas. | mycetes are ubiquitous organisms that can cause mycoses in human and animals. the role of animals in the epidemiology of human mycoses in urban areas is multiform, but here will be discuss only two features: a) animals as vectors of mycoses and b) animal substrates as growth factor of pathogenic fungi. a) animals as vectors of mycoses: this role is important as zoofilic dermatophytes are very important agents of zoonosis; the urban dermatophytozoonoses are prevalent caused by microsporum canis w ... | 2006 | 16881412 |
| [mixed dermatophyte infection in a cat]. | skin mycoses in animals are mostly caused by microsporum canis, microsporum persicolor, microsporum gypseum and in rare cases by trichophyton mentagrophytes. as a rule only one dermatophyte species is isolated from skin lesions, but at times mixed infection with bacteria occur. in the described case in a cat with typical dermatomycosis, microsporum canis and trichophyton mentagrophytes were isolated simultaneously. to the best of our knowledge this is the first case of mixed dermatophyte infecti ... | 2001 | 16886403 |
| incidence of tinea capitis in são paulo, brazil. | to determine the incidence of tinea capitis in são paulo, brazil, an investigation was performed in private and public pediatrics service involving 4,500 children from 0 to 15 years old during 5 years (1996-2000). samples were taken from 132 children with suspected fungal infection of the scalp, for direct microscopy and culture. tinea of scalp was mycologically confirmed in 112 patients (85%). males were more affected than females in all age groups. children below 8 years old accounted for more ... | 2006 | 16897586 |
| importance of mycological confirmation of clinically suspected cases of tinea corporis, tinea pedis and tinea cruris. | tinea corporis, tinea cruris, and tinea pedis are of the most prevalent dermatophytoses. several conditions that mimic dermatophytoses and atypical and steroid modified forms of the disease usually present difficulties in diagnosis. hence, the present investigation aimed at studying these conditions on mycological basis. the study included 163 cases clinically diagnosed as having tinea corporis, tinea pedis or tinea cruris. specimens were taken by skin scraping. samples were cultured on sabourau ... | 2004 | 16916049 |
| in vitro antifungal and anti-elastase activity of some aliphatic aldehydes from olea europaea l. fruit. | olea europaea preparations are traditionally employed in a variety of troubles, including skin infections. olive extracts and some of their pure compounds have shown antimicrobial activity in vitro. the present study deals with the antifungal activity of some aliphatic aldehydes from olive fruit [hexanal, nonanal, (e)-2-hexenal, (e)-2-heptenal, (e)-2-octenal, (e)-2-nonenal] against tricophyton mentagrophytes (6 strains), microsporum canis (1 strains) and candida spp. (7 strains). the capability ... | 2006 | 16920510 |
| tinea incognito in italy: a 15-year survey. | tinea incognito or steroid modified tinea is a dermatophytic infection in which topical or systemic steroids, administered as a result of dermatological misdiagnosis or preexisting pathologies, have modified the clinical appearance of the fungal infection, transforming the typical ringworm and mimicking other skin diseases. this is a retrospective study of the agents, clinical aspects, sources of infection of 200 cases (98 males, 102 females, mean age 42 years) of tinea incognito, observed in si ... | 2006 | 16922789 |
| isolation of microsporum canis from the hair coat of pet dogs and cats belonging to owners diagnosed with m. canis tinea corporis. | microsporum canis has been frequently isolated from human cases of tinea capitis and tinea corporis. the infection may be acquired from infected animals with cutaneous lesions but also from asymptomatic carriers or from the environment. as asymptomatic m. canis carriers are considered to be a critical factor in the epidemiology of dermatophytosis in humans, this study investigated the relationship between the presence of dermatophytes on the hair coats of dogs and cats without cutaneous lesions ... | 2006 | 16961818 |
| "carry-on" dermal baggage: a nodule from a dog. pyogranulomatous inflammation with intralesional fungal agents. | a 2-year-old intact female australian cattle dog presented with a 1-cm diameter nonexudative dermal nodule on the medial aspect of the right thigh. fine-needle aspiration revealed pyogranulomatous inflammation and many ovoid, 2-4 microm diameter, thin-capsulated, basophilic bodies that appeared to be fungal spores or yeast. results of cbc, serum chemistry panel, lymph node palpation, and radiographs were unremarkable. excisional biopsy and histopathology revealed pyogranulomatous folliculitis, f ... | 2006 | 16967419 |
| persistence of antibodies in blood and body fluids in decaying fox carcasses, as exemplified by antibodies against microsporum canis. | to assist in evaluating serological test results from dead animals, 10 silver foxes (vulpes vulpes) and 10 blue foxes (alopex lagopus), 6 of each species previously vaccinated against and all challenged with microsporum canis, were blood sampled and euthanased. fox carcasses were stored at +10 degrees c, and autopsy was performed on days 0, 2, 4, 7, and 11 post mortem during which samples from blood and/or body fluid from the thoracic cavity were collected. antibodies against m. canis were measu ... | 2006 | 16987389 |
| fontana-positive grains in mycetoma caused by microsporum canis. | we describe mycetoma caused by microsporum canis occurring in a 9-year-old african-american girl. pathologic evaluation showed a granulomatous dermatitis with numerous large fungal grains containing septate hyphae that were fontana-masson positive. two cultures of pure grains grew m. canis. mycetoma due to dermatophytes is very uncommon. the few instances reported have been pseudomycetoma (grains in the absence of sinus tracts). our patient developed sinus tracts (true mycetoma). no prior report ... | 2006 | 17014645 |
| study of the its region in an atypical isolate and comparison with six species of microsporum. | microsporum species are a frequent cause of cutaneous mycoses in humans. atypical strains of microsporum can sometimes be difficult to identify with conventional methods. recently, we have obtained a microsporum isolate with atypical morphology and special nutritional requirements (microsporum chus-126-02). as several molecular techniques have been developed for the identification of fungi, we analysed six microsporum species (m. canis, m. gypseum, m. gallinae, m. nanum, m. ferrugineum and m. pe ... | 2006 | 17022760 |
| prevalence of dermatophytosis in junior secondary schoolchildren in ogun state, nigeria. | a total of 2772 randomly selected junior secondary school pupils (aged 8-14) from 60 schools were examined for dermatophytic infections by direct microscopy and culture-based laboratory diagnostic methods. of these, 641 (23.21%) had dermatophytosis. out of these, 376 (13.56%) were male while 265 (9.56%) were female. aetiological agents identified with infection were microsporum canis (30.19%), microsporum audouinii (32.92%), trichophyton interdigitale (14.37%), trichophyton soudanense (9.73%) an ... | 2006 | 17022768 |
| canine dermatophytosis caused by an anthropophilic species: molecular and phenotypical characterization of trichophyton tonsurans. | microsporum canis is the most common species isolated from canine and feline dermatophytosis in the world. however, this study reports a rare case of canine dermatophytosis caused by the anthropophilic dermatophyte trichophyton tonsurans in the city of fortaleza, ceará, brazil. the fungal characterization was performed by classical mycological examination and by genotypical analysis using the restriction enzymes sau3a, rsai, ddei and ecori. the phenotypical characteristics were compatible with t ... | 2006 | 17030920 |
| in vitro activity of citrus bergamia (bergamot) oil against clinical isolates of dermatophytes. | recently, bergamot oil was shown to be a potent antifungal agent in vitro against clinically important candida species. in this study, the activities of bergamot natural essence and its furocoumarin-free and distilled extracts on dermatophytes such as trichophyton, microsporum and epidermophyton species were investigated. | 2007 | 17118937 |
| use of isolated infected spores to determine the sporocidal efficacy of two commercial antifungal rinses against microsporum canis. | in this study, isolated infective microsporum canis spores were used in an in vitro test model to compare the sporocidal activity of two commercial topical antifungal rinses. the two commercial test solutions used in the study were a lime sulphur solution 97.8% (lymdyp) and miconazole base 5.2%/chlorhexidine gluconate 5.9% mixture (malaseb concentrate rinse). water and household bleach were used as controls. isolated infective spores were harvested from infected hairs and 500 microl of the spore ... | 2007 | 17222242 |
| in-vitro antibacterial, antifungal and cytotoxic activity of cobalt (ii), copper (ii), nickel (ii) and zinc (ii) complexes with furanylmethyl- and thienylmethyl-dithiolenes: [1, 3-dithiole- 2-one and 1,3-dithiole-2-thione]. | some antibacterial and antifungal furanylmethyl-and thienylmethyl dithiolenes and, their co(ii), cu(ii), ni (ii) and zn (ii) complexes have been synthesized, characterized and screened for their in vitro antibacterial activity against four gram-negative; escherichia coli, pseudomonas aeruginosa, salmonella typhi and shigella flexeneri, and two gram-positive; bacillus subtilis and staphylococcus aureus bacterial strains, and for in-vitro antifungal activity against trichophyton longifusus, candid ... | 2006 | 17252947 |
| antimicrobial bioassay of colchicum luteum baker. | the methanolic extract of the corms of colchicum luteum baker (liliaceae) and its subsequent fractions in different solvent systems were screened for antibacterial and antifungal activities. the crude extract and all the fractions demonstrated moderate to excellent antifungal activities against tested pathogens in antifungal bioassay. excellent antifungal activity was shown against trichophyton longifusus, up to 75%, and microsporum canis, up to 85%, while the crude extract and subsequent fracti ... | 2006 | 17252951 |
| in-vitro antibacterial, antifungal and cytotoxic properties of metal-based furanyl derived sulfonamides. | a new series of antibacterial and antifungal furanyl-derived sulfonamides and their cobalt (ii), copper (ii), nickel (ii) and zinc (ii) metal complexes have been synthesized, characterized and screened for their in-vitro antibacterial activity against four gram-negative (escherichia coli, shigella flexneri, pseudomonas aeruginosa and salmonella typhi) and two gram-positive (bacillus subtilis and staphylococcus aureus) bacterial strains and, for in-vitro antifungal activity against trichophyton l ... | 2006 | 17252952 |
| glucose improves the in vitro viability of microsporum canis and trichophyton mentagrophytes var. mentagrophytes. | we describe simple and cost-effective methods using carbohydrates to improve the in vitro viability of dermatophytes. glucose and sucrose in different concentrations (3, 6, 9 and 12%) were used to maintain fifteen strains of m. canis and t. mentagrophytes var. mentagrophytes at 4 and -20 degrees c. the strains were phenotypically analyzed before storage and reevaluated at 1, 3, 6 and 9 months. at 1 and 3 months, any alterations in the viability or phenotype pattern of the stored strains were not ... | 2007 | 17254654 |
| isolation and identification of a new antifungal sesquiterpene lactone from inula viscosa. | a new sesquiterpene - tayunin - has been isolated and purified from powdered leaves of inula viscosa (l.) ait. the chemical structure was determined by 1d and 2d nmr analysis, and ir and ms. tayunin inhibits the growth of microsporum canis at a concentration of 10 microg/ml and trichophyton rubrum at 50 microg/ml(mic). | 1999 | 17260308 |
| dermatophytes and other fungi associated with skin mycoses in tripoli, libya. | our objective in this study was to obtain information on the prevalence of fungi responsible for superficial mycoses in the region of tripoli, libya. | 2001 | 17264550 |
| five-hour diagnosis of dermatophyte nail infections with specific detection of trichophyton rubrum. | a rapid two-step dna extraction method and a multiplex pcr for the detection of dermatophytes in general and trichophyton rubrum specifically were developed and evaluated with dna extracted from pure cultures and from clinically diseased nails. dna from the following dermatophytes was used: epidermophyton floccosum, microsporum audouinii, microsporum canis, microsporum gypseum, microsporum nanum, trichophyton mentagrophytes, trichophyton rubrum, trichophyton schoenleinii, trichophyton soudanense ... | 2007 | 17267633 |
| tinea capitis in a paediatric population. | tinea capitis is an increasing problem in europe. the pattern of infection is changing with an increase in pathogenic anthropophilic dermatophytes particularly trichophyton tonsurans. we aimed to determine the frequency of tinea capitis in a paediatric population attending dermatology outpatients and examine the clinical spectrum of disease. a retrospective analysis was performed of all laboratory proven tinea capitis cases presenting to the dermatology outpatient department at the children's un ... | 2006 | 17274169 |
| species distribution and antifungal susceptibilities of dermatophytes during a one year period at a university hospital in turkey. | dermatophyte infections have been considered to be a major public health problem in many parts of the world. the aim of this study was to determine the causative agents of dermatophytoses and their antifungal susceptibilities in a turkish university hospital, west of turkey. a total of 926 patients suspected to have dermatophytic lesions were examined over a period of 1 year (2001-2002). samples collected from skin, hair and nails were submitted to direct microscopical examination using koh and ... | 2007 | 17305776 |
| asymptomatic dermatophyte scalp carriage in school children in adana, turkey. | the aim of this study was to determine the prevalence of asymptomatic dermatophyte scalp carriage and symptomatic tinea capitis in adana province, cukurova region, turkey. for this purpose, a screening study was performed in five schools, between january 2004 and may 2005, covering a total of 5143 children with 2740 (53.3%) boys and 2403 (46.7%) girls, aged 7-14 years (9.6 +/- 2.0). the diagnosis was made using the cotton swab method with inoculation onto sabouraud glucose agar amended with cycl ... | 2007 | 17305777 |
| atypical favic invasion of the scalp by microsporum canis: report of a case and review of reported cases caused by microsporum species. | favus is an uncommon pattern of dermatophytic infection of the scalp, glabrous skin and nails. we report the first documented case of favus of the scalp caused by microsporum canis in an immunocompetent 8-year-old girl. the classic and various atypical clinical presentations of favus are discussed, as well as a brief review of the literature given. | 2007 | 17305783 |
| [dermatophytoses transmitted from animals]. | dermatophytoses are infectious skin diseases caused by some sorts of fungi - dermatophytes. based on their source dermatophytes are classified to geophilic, zoophilic and antrophophilic groups. animals are primary afflicted by zoophilic fungi, manifestations on their skin are highly infectious and fungi can be transmitted to humans. some members of zoophilic dermatophytes are: microsporum canis, trichophyton mentagrophytes var. mentagrophytes and trichophyton verrucosum. most common clinical fin ... | 2006 | 17323620 |
| epidemiology of dermatophytic infections in rome, italy: a retrospective study from 2002 to 2004. | in the present study, we determined the incidence of dermatophyte species causing superficial mycoses among outpatients referred to the department of dermatology of the "la sapienza" university of rome between 2002 and 2004. of the 3160 subjects studied, 1275 (40.3%) were positive for fungal infection, but only 252 (19.7%) of these had infections caused by dermatophytes. the dermatophyte most frequently isolated was microsporum canis. our epidemiological data were compared with those obtained pr ... | 2007 | 17325945 |
| analysis of the dermatophyte species isolated in the british isles between 1980 and 2005 and review of worldwide dermatophyte trends over the last three decades. | infections of the skin, hair and nails by dermatophyte fungi are common in developed and developing countries alike. however, the species involved and the resulting clinical entities vary both geographically and with time. we have surveyed 15,333 dermatophytes obtained from primary isolations at the mycology reference laboratory, bristol, uk from 1980 through 2005. several striking trends in dermatophyte prevalence were apparent over this period. the relative frequencies of isolations of microsp ... | 2007 | 17365649 |
| chemical composition, toxicological aspects and antifungal activity of essential oil from lippia sidoides cham. | the aims of this study were to test the essential oil from lippia sidoides cham. for antifungal activity, in vitro, against candida spp. and microsporum canis, to evaluate its acute and subchronic toxicological effects, in vivo, and to determine its chemical constituents. | 2007 | 17376793 |
| pseudomycetoma caused by microsporum canis in an immunosuppressed patient: a case report and review of the literature. | a 65-year-old woman with a history of liver and kidney transplantation presented with a pruritic and tender rash of 2-year duration on her left knee. | 2007 | 17448202 |
| identification of microsporum canis from dermatophytic pseudomycetoma in paraffin-embedded veterinary specimens using a common pcr protocol. | the effectiveness of a simple pcr protocol performed on paraffin-embedded tissues, obtained from histopathologically and culturally diagnosed cases of dermatophytic pseudomycetoma dpm was tested. the specimens were investigated using previously described primers (dh1l and dh1r) targeting the 18s rdna gene and amplifying a 183-bp fragment. microsporum canis was identified from all samples. the pcr protocol described in the present work demonstrated a 100% concordant result comparing the molecular ... | 2007 | 17472620 |
| ethnoveterinary study for antidermatophytic activity of piper betle, alpinia galanga and allium ascalonicum extracts in vitro. | crude ethanolic extracts of piper betle leaves (piperaceae), alpinia galanga rhizomes (zingiberaceae) and allium ascalonicum bulbs (liliaceae) were tested against selected zoonotic dermatophytes (microsporum canis, microsporum gypseum and trichophyton mentagrophyte) and the yeast-like candida albicans. a broth dilution method was employed to determine the inhibitory effect of the extracts and compared to those of ketoconazole and griseofulvin. all extracts suppressed the growth of the fungi in a ... | 2008 | 17482221 |
| metal-based antibacterial and antifungal agents: synthesis, characterization, and in vitro biological evaluation of co(ii), cu(ii), ni(ii), and zn(ii) complexes with amino acid-derived compounds. | a series of antibacterial and antifungal amino acid-derived compounds and their cobalt(ii), copper(ii), nickel(ii), and zinc(ii) metal complexes have been synthesized and characterized by their elemental analyses, molar conductances, magnetic moments, and ir, and electronic spectral measurements. ligands (l(1))-(l(5)) were derived by condensation of beta-diketones with glycine, phenylalanine, valine, and histidine and act as bidentate towards metal ions (cobalt, copper, nickel, and zinc) via the ... | 2006 | 17497020 |
| cytobrush-culture method to diagnose tinea capitis. | this is a comparative study to isolate the dermatophytes of tinea capitis using the cytobrush and comparing it versus the standard method. a prospective, observational, comparative trial of 178 probable cases of tinea capitis was conducted in two dermatological centers. each patient underwent mycological tests that included direct exam with koh and cultures with either of two methods: scraping the scalp to remove hair and cell debris, and the cytobrush. a total of 135 clinically and mycologicall ... | 2007 | 17520340 |
| microsporum canis: report of a primary school outbreak. | microsporum canis is the causative organism in less than 10% of all tinea capitis infections in the uk. transmission is generally via contact with an infected family pet and there are only rare reports of case clustering. this article describes an outbreak of m. canis in a primary school classroom demonstrating human-to-human spread from an index case who was presumed to have acquired the infection prior to arriving in the uk. there was no suggestion of clinical improvement following 4 weeks of ... | 2007 | 17535194 |
| pseudomycetoma for microsporum canis: report of a case diagnosed by fine needle aspiration biopsy. | fine needle aspiration biopsy (fnab) of the skin is useful in subcutaneous lesions. dermatophytes are almost exclusively superficial cutaneous mycoses and constitute 70-80% of all mycoses and 5% of dermatologic consultations. inflammatory and invasive forms, as well as infections that remain in chronic forms or persist in spite of treatment, are more frequent in immunocompromised individuals. the clinicalpresentations of these invasive cases are dermatopbytic granulomas (granuloma of wilson-majo ... | 2007 | 17536547 |
| antifungal activity of the silver ion against contaminated fabric. | an anti-fungal efficacy test of the silver laundry machine, which electrically generates silver ions, was carried out against four fungi--trichophyton rubrum, candida albicans, microsporum canis and aspergillus flavus--which cause major fungal infection in humans and animals. compared with the conventional laundry machine, washing with the silver laundry machine regardless of detergent use was effective against most of the fungi with about 4 log(10) (cfu ml(-1)) reduction and eliminated almost a ... | 2007 | 17576317 |
| prevalence of tinea capitis in southern kuwait. | tinea capitis of the scalp, an infection caused by dermatophytes, produces a significant health problem especially among school children. the object of this study was to highlight the prevalence of tinea capitis in southern kuwait. during this retrospective study from 1998 to 2003, 1737 suspected cases were examined, 986 (58.6%) were men and 751 (43.2%) were women of which 371 cases were diagnosed as tinea capitis. of 371 cases of tinea capitis, males comprised 54.2% and females 45.8%. young chi ... | 2007 | 17576327 |
| in vivo efficacy and pharmacokinetics of voriconazole in an animal model of dermatophytosis. | the standard treatment for tinea capitis caused by microsporum species for many years has been oral griseofulvin, which is no longer universally marketed. voriconazole has been demonstrated to inhibit growth of microsporum canis in vitro. we evaluated the efficacy and tissue pharmacokinetics of oral voriconazole in a guinea pig model of dermatophytosis. guinea pigs (n = 16) were inoculated with m. canis conidia on razed skin. voriconazole was dosed orally at 20 mg/kg/day for 12 days (days 3 to 1 ... | 2007 | 17576826 |
| reconstructed interfollicular feline epidermis as a model for microsporum canis dermatophytosis. | microsporum canis is a pathogenic fungus that causes a superficial cutaneous infection called dermatophytosis. the complexity of mechanisms involved in dermatophytic infections makes relevant in vivo studies particularly difficult to perform. the aim of this study was to develop a new in vitro model of m. canis dermatophytosis using feline fetal keratinocytes in reconstructed interfollicular epidermis, and to investigate its relevance in studying the host-pathogen relationship. histological anal ... | 2007 | 17577064 |
| extracellular proteolytic activity and molecular analysis of microsporum canis strains isolated from symptomatic and asymptomatic cats. | microsporum canis is the main zoophylic dermatophyte in dogs and cats, and it is also an important zoonotic agent. the literature showed that cats are asymptomatic carriers of m. canis. this is apparently due to host resistance and/or the presence of strains with lower virulence. this study was aimed to evaluate the keratinolytic, elastinolytic and collagenolytic activities of m. canis strains and their relationship with symptomatic and asymptomatic cats. in addition, these strains were analysed ... | 2007 | 17592886 |
| in vitro antifungal activity of rhazya stricta. | rhazya stricta is a small glabrous shrub, widely distributed throughout western asia from yemen to arabia, to the north west province of india and abundantly found in various regions of pakistan. larvicidal and antifungal studies of polar and non polar aerial parts extracts of rhazya stricta were performed using brine shrimps larvae for larvicidal study and for antifungal study microorganisms, trichophyton longifusis, aspergillus flavus, candida albicans, microsporum canis and fusarium solani we ... | 2007 | 17604249 |
| design, synthesis, and antifungal activities of novel 1h-triazole derivatives based on the structure of the active site of fungal lanosterol 14 alpha-demethylase (cyp51). | a series of fluconazole (1) analogues, compounds 3a-k, were prepared as potential antifungal agents. they were designed by computational docking experiments to the active site of the cytochrome p450 14alpha-sterol demethylase (cyp51), whose crystal structure is known. preliminary biological tests showed that most of the target compounds exhibit significant activities against the eight most-common pathogenic fungi. thereby, the most potent congener, 1-[(4-tert-butylbenzyl)(cyclopropyl)amino]-2-(2 ... | 2007 | 17638327 |
| familial keratosis follicularis spinulosa decalvans associated with woolly hair. | keratosis follicularis spinulosa decalvans (kfsd) is a rare inherited disorder of keratinization clinically characterized by diffuse follicular hyperkeratosis, progressive scarring alopecia of scalp, eyebrows and eyelashes, corneal dystrophy and photophobia. woolly hair is a hereditary condition, transmitted as an autosomal dominant or recessive trait, usually seen in caucasians at birth or shortly after, in which there are curly, thick, often heavily pigmented hairs. we report two cases, a son ... | 2007 | 17651168 |