Publications

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[importance of the cat in the transmission of microsporum canis in rio grande do sul (brazil)]. 196113763293
[rapid cure of ringworm of the scalp caused by microsporum canis with an acid pomade & iodine]. 195813608248
griseofulvin in treatment of infections of scalp due to microsporum canis. 195913797908
carbohydrate metabolism in microsporum canis. 196013809439
observations on the treatment of microsporum canis tinea capitis with griseofulvin. 195913852346
microsporum canis infection in man and animals. 195913852345
[cure in about 10 days of tinea caused by "microsporum canis" by the addition of griseofulvin to the local therapy previously used alone]. 195913853799
the amino acid metabolism of microsporum canis. 196213878414
the trichophyton mentagrophytes and microsporum canis infection of the guinea-pig. 196313949396
on 1117 microsporum canis infections in montreal (1954-1961). 196313984486
[role of microsporum canis in the production of tineas in madrid]. 196314013430
[microsporia caused by microsporum canis]. 196113905384
absence of kynurenine in cultures of microsporum canis grown in tryptophane enriched sabouraud's agar. 196314085452
corneal ulcer and conjunctivitis caused by microsporum canis. 196314099408
[study of a case of tinea capitis caused by microsporum canis in an adult]. 196213914918
microsporum canis infection in cats treated with griseofulvin. 196213920963
fine particle griseofulvin: a preliminary report of clinical experiences in the treatment of microsporum canis infection of the scalp. 196214028572
microsporum canis dermatomycosis. 196514261913
the treatment of microsporum canis infection in cats with fine-particle griseofulvin. 196414220835
tinea barba due to microsporum canis. 196514229602
[on the isolation of an atypical strain of microsporum canis from a whitehanded gibbon (hylobates lar)]. 196414230191
keratinolytic activity of microsporum canis and microsporum gypseum. 196514290300
microsporum canis. pets and human ringworm. 196214466324
constituents of the argentinian medicinal plant baccharis grisebachii and their antimicrobial activity.the resinous exudate of baccharis grisebachii which is used to treat ulcers, burns, and skin sores in argentina showed activity towards dermatophytes and bacteria. two diterpenes, eight p-coumaric acid derivatives, and two flavones were isolated from the exudate and the structures elucidated by spectroscopic methods. 3-prenyl-p-coumaric acid and 3,5-diprenyl-p-coumaric acid were active towards epidermophyton floccosum and trichophyton rubrum with mics of 50 and 100-125 microg/ml, respectively. t ...200314522435
[epidemiological survey of dermatophytosis in spain (april-june 2001)].a three-month (april-june 2001) cross-sectional study was designed to assess the epidemiological profile of dermatophytosis in spain.200314572379
[in vitro activity of voriconazole and three other antifungal agents against dermatophytes].the increase in infections due to dermatophytes in recent years led us to study the effectiveness of new antifungal formulations against these microorganisms.200314572380
[current types of human dermatophytoses transmitted from animals].microsporum canis, trichophyton verrucosum and t. mentagrophytes are the most common dermatophytes isolated from human and animals. m. canis infection in human is closely related to companion animals such as cats and dogs. according to a recent epidemiological survey in japan, human m. canis infection is decreasing. t. verrucosum is usually transmitted from cows to human. t. verrucosum infection in human is not restricted to daily farming prefectures, however, suggesting that this species has al ...200314615787
epidemiology of dermatophyte infection in auckland, new zealand.this report describes the epidemiology of culture-proven dermatophyte infection in auckland, new zealand. the authors undertook a retrospective review of laboratory data for the period from june 1999 to july 2002. there were 10 004 dermatophyte isolates. the most common isolates were trichophyton rubrum (69%) and trichophyton mentagrophytes (19%). microsporum canis was mainly isolated from children. the prevalence of t. mentagrophytes increased with patient age (p < 0.001). trichophyton rubrum w ...200314616492
environmental detection of microsporum canis arthrospores in the households of infected cats and dogs.microsporum canis is the dermatophyte most frequently recovered from canine and feline ringworm cases. the household environment can be contaminated both by symptomatic animals and through asymptomatic m canis carriage, resulting in a potential human health risk. the load of m canis arthrospores was determined in households harbouring infected pets, in order to evaluate the infectivity of the animals versus the environment. the environments inhabited by 30 symptomatic animals (21 cats and 9 dogs ...200314623201
microsporum canis infection of the scalp in an adult with cicatricial alopecia. 195514363571
dermal mass aspirate from a persian cat.a 1-year-old spayed female persian cat with alopecia and weight loss had numerous variably ulcerated dermal nodules. cytologic examination of an aspirate of one of the nodules revealed pyogranulomatous inflammation along with septate hyphae and basophilic round bodies, 0.5-1.0 microm in diameter, surrounded by a thin clear halo (arthrospores). the cytologic diagnosis was dermatophytic pseudomycetoma. histologically, there were dermal granulomas containing poorly staining, septate hyphae with bul ...200314655108
a ringworm epidemic caused by microsporum canis in a rural community. 196014428785
a recombinant 31.5 kda keratinase and a crude exo-antigen from microsporum canis fail to protect against a homologous experimental infection in guinea pigs.a microsporum canis recombinant 31.5 kda keratinase and a m. canis crude exo-antigen were tested as vaccines in an experimental infection model in guinea pigs. animals were vaccinated subcutaneously three times at two-week intervals with either the keratinase, the exo-antigen or the adjuvant alone. cutaneous challenge was performed blindly. both humoral and cellular-specific immune responses to m. canis antigens were evaluated every 14 days, while a blind evaluation of clinical lesion developmen ...200314678442
epidemiology of dermatophytoses in an area south of tehran, iran.dermatophyte infections have been considered to be a major public health problem in many parts of the world. the aim of this study was to identify the etiological and epidemiological factors of dermatophyte infections in an area south of tehran. a total of 1254 patients suspected to have dermatophytic lesions were examined over a period of three years (1999-2001). material collected from skin, hair, and nails was submitted to direct microscopic examination using koh, cultured in sabouraud dextro ...200314682452
occurrence of dermatomycoses and in-vitro therapeutic efficacy of three antifungal drugs on the growth of epidermophyton floccosum.the occurrence of dermatomycoses and the in-vitro therapeutic efficacy of some antifungal agents on dermatomycotic organisms were investigated. of the 550 primary school children screened, the incidence was one hundred (18%), 70 were males (representing 20% of the males screened) and 30 females (15% of the females sampled). the differences between male and female prevalence were insignificant. three species of dermatophytes were isolated and identified. these were microsporum canis, trichophyton ...200314682454
high rate of microsporum canis feline and canine dermatophytoses in northeast brazil: epidemiological and diagnostic features.over a one year period (november 2000-december 2001), clinical specimens from 189 dogs and 38 cats, from the city of fortaleza, ceará, brazil, were examined at the specialized medical mycology center at the federal university of ceará to detect animals with dermatophytoses. the mycological analyses were conducted by direct microscopy and by fungal culture on sabouraud agar, sabouraud chloramphenicol agar and mycosel agar. dermatophytes were isolated from 27 of the 189 (14.3%) canine specimens an ...200314682455
[microsporia epidemic due to microsporum canis in southwest germany]. 195914443376
action mechanisms of modern antifungal agents and resulting problems in the management of onychomycosis.successful treatment of onychomycosis in the infection site depends not only on achieving the minimal inhibitory concentration (mic) of the antifungal agent, usually determined on fresh, proliferating fungal strains, but also on the effectivity against fungal spores dormant in nail keratin. ciclopiroxolamine and terbinafine were investigated for their fungicidal properties against proliferating and dormant dermatophyte strains. while ciclopiroxolamine was 100% effective against trichophyton ment ...200314641625
tinea barbae (tinea sycosis): experience with nine cases.tinea barbae is a rare dermatophytosis that affects the hair and hair follicles of the beard and mustache. this paper presents 9 cases of tinea barbae observed over an 18-year period of time and classified as follows: 1 was superficial and 8 were deep (6 folliculitis-like and 2 kerion-like). most of the cases (4) were associated with topical steroid therapy, others with pet contact (3 cases) and one with diabetes. the causal agents isolated were: trichophyton rubrum in 3; microsporum canis in 3; ...200314739517
tinea capitis among children and adolescents in the farwaniya region of kuwait.analysis of 325 patients (182 males, 143 females) of mycologically proven tinea capitis (tc) seen over a period of two years from january 2001--december 2002 in the farwaniya region of kuwait is presented in this study. the age range was 8 months to 17 years. peak incidence was observed in the 3-14 year age group (79.6%). positive family history and contact with pets were noted in 22% and 36.7% of the cases, respectively. the non-inflammatory 'gray patch' variety was the most common clinical typ ...200314739518
dermatophyte agents in the city of são paulo, from 1992 to 2002.dermatophytosis are superficial mycoses caused by fungi that can invade stratum corneum and keratinized tissues. in order to study the frequency of dermatophytes species and the clinical manifestations caused by these fungi, in são paulo, sp, brazil, the authors analyzed cultures isolated at the mycology laboratory from a selected population (15,300 out-patients of the hospital das clínicas, department of dermatology, faculty of medicine of university of são paulo) from january 1992 to june 2002 ...200314743665
derivatives of phosphate schiff base transition metal complexes: synthesis, studies and biological activity.we report the synthesis and structural characterization of series of tetra- and hexacoordinate metal chelate complexes of phosphate schiff base ligands having the general composition lmx(n).h(2)o and l(2)mx(n) (l=phosphate schiff base ligand; m=ag(+), mn(2+), cu(2+), zn(2+), cd(2+), hg(2+), or fe(3+) and x=no(3)(-), br(-) or cl(-)). the structure of the prepared compounds was investigated using elemental analysis, ir, 1h and 31p nmr, uv-vis, mass spectra, solid reflectance, magnetic susceptibili ...200414670488
antimicrobial activity of hyptis ovalifolia towards dermatophytes.the essential oil and the aqueous, hexane and methanolic fractions from hyptis ovalifolia leaves were evaluated for their antifungal activity in vitro against 60 strains of dermatophytes: 10 strains of microsporum canis, 10 of m. gypseum, 20 of trichophyton rubrum and 20 of t. mentagrophytes. the extracts inhibited growth of the dermatophytes tested at different concentrations. the most biologically active was the essential oil from the leaves which inhibited 57 isolates (95%) at a concentration ...200414762526
multiplication of an ancestral gene encoding secreted fungalysin preceded species differentiation in the dermatophytes trichophyton and microsporum.dermatophytes are human and animal pathogenic fungi which cause cutaneous infections and grow exclusively in the stratum corneum, nails and hair. in a culture medium containing soy proteins as sole nitrogen source a substantial proteolytic activity was secreted by trichophyton rubrum, trichophyton mentagrophytes and microsporum canis. this proteolytic activity was 55-75 % inhibited by o-phenanthroline, attesting that metalloproteases were secreted by all three species. using a consensus probe co ...200414766908
pcr and pcr-rflp techniques targeting the dna topoisomerase ii gene for rapid clinical diagnosis of the etiologic agent of dermatophytosis.we have focused on the dna topoisomerase ii genes of several pathogenic fungi, and developed polymerase chain reaction (pcr) and pcr-restriction fragment length polymorphism (rflp) methods targeting this gene for identification of dermatophytes.200414757280
the effect of various substances on the oxygen uptake of microsporum canis growth in submerged culture. 195114850779
the pathogenesis of tinea capitis due to microsporum audouini and microsporum canis. i. gross observations following the inoculation of humans. 195214908198
isolation of a promoter region of a secreted metalloprotease gene from microsporum canis.mep3 of microsporum canis encodes a 43.5 kda extracellular keratinolytic metalloprotease, which is thought to be one of the virulence-related factors in dermatophytosis. in order to analyze the system underlying the regulation of mep3 gene expression, the 5'-upstream region was isolated by inverse pcr. the nucleotide sequence of a dna fragment of about 2.1 kb containing the coding region contains putative transcription factor binding sites and transcriptional initiation points. further analyses ...200414985633
therapeutic options in the treatment of tinea capitis.tinea capitis is primarily a disease of pre-adolescent children. in north america and the uk, trichophyton tonsurans is responsible for > 90% of cases. microsporum canis is the predominant pathogen in certain parts of europe. the standard of care for the treatment of tinea capitis is oral griseofulvin and so far, it remains the only medication approved by the us fda for this condition. the newer oral antifungal agents, such as terbinafine, itraconazole and fluconazole, appear to be effective, sa ...200414996619
in vitro antifungal activity of sertaconazole against 309 dermatophyte clinical isolates.three hundred and nine strains belonging to 11 species of dermatophyte moulds were tested against sertaconazole following mainly the national committee for clinical laboratory standards (m38-p) for filamentous fungi. however, several important factors such as the temperature (28 degrees c vs 35 degrees c) and time of incubation (4-10 d vs 21-74 h), have been modified. sertaconazole was active against all the clinically important dermatophyte moulds involved in human infections tested. overall ge ...200314998079
molecular typing study of the microsporum canis strains isolated from an outbreak of tinea capitis in a school.tinea capitis is a dermatophyte infection of the scalp that occurs most often in prepubescent children. tinea capitis may be transmitted by shared use of contaminated hairbrush, by contact with fomites or by direct physical contact with an infected person. occasionally, outbreak of tinea capitis would happen under some special conditions. last year, we found an outbreak of tinea capitis in a school due to microsporum canis. in epidemiological study, we performed the prevalence survey to all of t ...200415008343
efficacy and tolerability of 8 weeks' treatment with terbinafine in children with tinea capitis caused by microsporum canis: a comparison of three doses.tinea capitis caused by microsporum canis is the most common mycosis of the scalp in preschool and school-aged children in greece.200415009293
humoral and cellular immune response to a microsporum canis recombinant keratinolytic metalloprotease (r-mep3) in experimentally infected guinea pigs.in order to better understand the host-fungus relationship in microsporum canis dermatophytosis and to identify major fungal antigens, the immune response to a crude exoantigen preparation and to a purified recombinant keratinolytic metalloprotease (r-mep3) was evaluated in guinea pigs experimentally infected with m. canis. humoral and cellular immune responses were assessed from day 0 to day 57 post-infection (pi), the former by enzyme-linked immunosorbent assay (elisa) and the latter via a lym ...200314725323
[tinea capitis in children from goiânia, brazil].during the period january 1999 to july 2002 a total de 164 cases of tinea capitis were diagnosed by mycological examination in instituto de patologia tropical e saúde pública of the universidade federal de goiás. of the 164 patients 94 (57.3%) were males, with an age of 3 months to 13 years. laboratory studies were performed by direct examination with 20% koh and cultivated on mycobiotic agar medium and sabouraud dextrose agar with chloramphenicol. the following species were identified: microspo ...200315049102
treatment of microsporum spp. tinea capitis with pulsed oral terbinafine.oral terbinafine is widely used in the treatment of superficial dermatomycoses as well as subcutaneous and systemic mycoses. it is also useful in treating tinea capitis, although for microsporum canis and some ectothrix organisms, the effectiveness of the drug may be less than for some endothrix infections. in this study, we undertook a double-blind randomized trial comparing standard and double doses of terbinafine given in a pulsed protocol (1 week on, 3 weeks off) in treating microsporum spp. ...200415115516
study of the dermatophytes in dogs and the risk of human infection.the infiltrative growth of fungi that multiplies in the tissues (dermatophytes, candida, agents of visceral mycoses) is the generally known proof of "active" functioning of these organisms. the relative importance of fungi as inducers of human and animal diseases grows constantly.200315168865
evaluation of immunogenicity and protective efficacy of a microsporum canis metalloprotease subunit vaccine in guinea pigs.in order to identify protective immunogens against microsporum canis infection, a purified recombinant keratinolytic metalloprotease (r-mep3) was tested as a subunit vaccine in experimentally infected guinea pigs. both humoral and cellular specific immune responses developing towards r-mep3 were evaluated, by enzyme-linked immunosorbent assay and by in vitro lymphocyte transformation tests respectively. vaccination induced a strong antibody response, and a significant but transient lymphoprolife ...200414734190
new treatments for tinea capitis.tinea capitis, a dermatophyte infection involving the hair shaft on the scalp, is primarily a disease of preadolescent children. the predominant pathogen varies according to the geographical location. trichophyton tonsurans and microsporum canis account for the majority of infections in north america and certain parts of europe. the current standard of care for the treatment of tinea capitis in the usa is oral griseofulvin, but evidence is accumulating that some of the newer antifungal agents ma ...200415021047
effect of roentgen rays on microsporum canis; an in vitro study. 195114829055
kerion celsi in a newborn due to microsporum canis.the present study deals with a case of a 40-day-old girl with kerion celsi caused by microsporum canis. the source of the infection were the parents who presented tinea corporis caused by m. canis. systemic treatment was carried out with terbinafine and complete recovery was achieved. tinea capitis is unusual in children during their first year of life and its evolution towards kerion is very rare in newborns.200415189191
development of an in vitro, isolated, infected spore testing model for disinfectant testing of microsporum canis isolates.the isolated infected hair model is a commonly used technique to test the fungicidal efficacy of topical therapies against microsporum canis. the most commonly used model uses mats of infective hairs, and results from various laboratories have differed. the objectives of this study were to develop a method to produce spores for testing when only mycelial forms were available and to develop a semiquantitative testing method that used only infective spores from hairs, and not pooled hair samples f ...200415214954
generalized microsporum canis dermatophytosis in six yorkshire terrier dogs.six yorkshire terrier dogs with generalized, chronic dermatophytosis caused by microsporum canis were seen over a 3-year period. specific tests showed that they also had concurrent leishmaniosis (four cases), leishmaniosis and ehrlichiosis (one case) or diabetes mellitus (one case). although specific therapy for these infectious diseases was instituted and the dogs were treated systemically and topically with appropriate antifungal drugs, only partial clinical resolution of the dermatophytosis w ...200415214955
intra- and interlaboratory study of a method for testing the antifungal susceptibilities of dermatophytes.the national committee for clinical laboratory standards (nccls) m38-a standard for the susceptibility testing of conidium-forming filamentous fungi does not explicitly address the testing of dermatophytes. this multicenter study, involving six laboratories, investigated the mic reproducibility of seven antifungal agents tested against 25 dermatophyte isolates (5 blinded pairs of five dermatophyte species per site for a total of 300 tests), using the method of dermatophyte testing developed at t ...200415243047
frequency and risk factors of dermatophytosis in students living in rural areas in eskişehir, turkey.our study included 2384 students from five villages around eskişehir, turkey. we asked every student for their personal identification and also for their sanitation in order to get an idea about dermatophytosis. samples taken from suspicious lesion were collected and inoculated onto sabouraud dextrose agar slants. for identification of fungi which were grown, macroscopic appearance of colonies, microscopic examination and biochemical tests were used. we found suspicious lesions in 245 (10.3%) an ...200415281399
etiology of tinea capitis in athens, greece -- a 6-year (1996-2001) retrospective study.a total of 577 patients with tinea capitis have been diagnosed at the mycology laboratory of 'a. sygros' hospital of skin and venereal diseases, athens, greece between 1996 and 2001. from these patients, 100 were immigrants from balkan, near east and african countries. the vast majority of the patients (95%) were children, mainly at preschool and school age and only 5% were adults. zoophilic dermatophytes accounted for 86.5% followed by anthropophilic (12.4%) and geophilic (1.2%) dermatophytes. ...200415189185
[statistical study of dermatomycosis for 30 years (1968-1997) in sendai national hospital].a statistical study on dermatomycoses for the 30 years from 1968 to 1997 in the dermatologic section of sendai national hospital was carried out with the following results. the total number of dermatomycosis patients was 14,259 and accounted for 9.59% of all new outpatients during this period. these cases of dermatomycoses were composed of the following: dermatophytoses 10,656, candidiasis 3,287, malassezia infection 566, sporothrichosis 20, aspergillosis 7, and chromomycosis 1. annual changes i ...200415284829
the epidemiology of microsporum canis infections in rijeka area, croatia.the aim of the study was to analyze the microsporum canis infections in the rijeka area, croatia, observed between 1990 and 2001. a total of 724 cases of dermatophytosis caused by m. canis were diagnosed in 320 individuals with the tinea capitis and 404 with tinea corporis. the m. canis infections constituted 32.8% of all dermatophytes isolated during the study period.200415189188
dermatophytoses in split and dalmatia, croatia, 1996-2002.the aim of the study was to investigate the epidemiology of dermatophyte infections in split and dalmatia county, croatia, between 1996 and 2002. of 5792 samples 1318 (23.8%) were positive. tinea corporis and tinea cruris were the most common types of dermatophytoses. microsporum canis (36.5%), trichophyton mentagrophytes (24.8%), and t. rubrum (21.5%) were the main etiologic factors.200415310333
dermatophytosis in children and adolescents in gdansk, poland.during a 3-year period (1999-2001) a total of 94 cases of dermatophytosis were seen in patients from 0 to 18 years of age attending the department of dermatology, venerology and allergology of gdańsk medical university. mycoses were diagnosed on the basis of clinical picture and direct microscopy and were confirmed by positive cultures. the most frequent pathogens were microsporum canis (62%) and trichophyton rubrum (12%). the most often forms of dermatophytosis in children were tinea cutis glab ...200415310339
the novel azole r126638 is a selective inhibitor of ergosterol synthesis in candida albicans, trichophyton spp., and microsporum canis.r126638 is a novel triazole with in vitro activity similar to that of itraconazole against dermatophytes, candida spp., and malassezia spp. in animal models of dermatophyte infections, r126638 showed superior antifungal activity. r126638 inhibits ergosterol synthesis in candida albicans, trichophyton mentagrophytes, trichophyton rubrum, and microsporum canis at nanomolar concentrations, with 50% inhibitory concentrations (ic(50)s) similar to those of itraconazole. the decreased synthesis of ergo ...200415328084
itraconazole in the treatment of tinea capitis caused by microsporum canis: experience in a large cohort.mycotic scalp infection caused by microsporum canis is one of the more recalcitrant disorders, with increasing incidence during the last decade. we report our experience with administration of itraconazole in 163 children (86 girls, 77 boys) with m. canis tinea capitis. fifty-five patients had previous treatment with terbinafine without success. in all children, the dosage of itraconazole was adjusted according to body weight, with 5 mg/kg/day given in a continuous regimen either as a capsule (1 ...200415283801
antifungal cobalt(ii), copper(ii), nickel(ii) and zinc(ii) complexes of furanyl-,thiophenyl-, pyrrolyl-, salicylyl- and pyridyl-derived cephalexins.some novel cephalexin-derived furanyl, thiophenyl, pyrrolyl, salicylyl and pyridyl schiff's bases and their cobalt (ii), copper (ii), nickel (ii) and zinc (ii) complexes have been synthesized and studied for their antifungal properties against trichophyton longifusus, candida albicans, aspergillus flavus, microsporum canis, fusarium solani and candida glaberata. the presence of metal ions in the investigated schiff's base complexes reported here lead to significant antifungal activity, whereas t ...200415202498
antibacterial and antifugal mono- and di-substituted symmetrical and unsymmetrical triazine-derived schiff-bases and their transition metal complexes.a new series of antibacterial and antifungal triazine-derived mono- and di-substituted (symmetrical and unsymmetrical) schiff-bases and their cobalt(ii), copper(ii), nickel(ii) and zinc(ii) metal complexes have been synthesized and characterized by their elemental analyses, molar conductances, magnetic moments and ir and electronic spectral measurements. ir spectra indicated the ligands to act as tridentate towards divalent metal ions via a trazine-n, the azomethine-n and, indole-nh and deproton ...200415449731
population structure and evolutionary origins of microsporum canis, m. ferrugineum and m. audouinii.the recurrent evolutionary emergence of asexual lineages within sexual zoo- and anthropophilic dermatophyte species living in animal-frequented soil is likely to be triggered by changes in ecological niche, i.e., shifts of host animal. subsequent adaptation to the new host species is noted. sometimes geographic isolation or intrinsic host factors like human race may also play a role in speciation. in the present study, we elaborate concepts of speciation in dermatophytes using the microsporum ca ...200415450196
lung cancer epidemiology and risk factors in asia and africa.in industrialised countries, lung cancer is the most common form of cancer among males and it is growing among females. for both sexes, rates reflect smoking behaviours. the pattern appears to be different in asia, particularly in china, where lung cancer rates in men reflect high smoking rates but high rates among non-smoking women appear to be related to other factors. the incidence of lung cancer is low in most african countries, but it is increasing. in addition to tobacco smoking, a number ...200415455588
tinea capitis in a dermatology center in the city of fortaleza, brazil: the role of trichophyton tonsurans.over a 3-year period (march 1999 to march 2002), 944 patients with scalp lesions attended a dermatology reference center in the city of fortaleza, ceará, brazil. clinical specimens were examined at the specialized medical mycology center, federal university of ceará, fortaleza-ce, brazil, to detect patients with tinea capitis.200415304180
effect of yeast extract on microsporum audouini and microsporum canis. 195015433400
tinea capitis caused by microsporum canis treated with terbinafine.tinea capitis is a disease found throughout the world. it frequently affects children and only rarely adults, usually post-menopausal women. numerous dermatophytes of the genus microsporum and tricophyton can cause tinea capitis and griseofulvin is still today the treatment of choice. to study the effectiveness and tolerability of terbinafine treatment in tinea capitis caused by microsporum canis we treated 26 patients - 22 children and four women - for a period of 12 weeks. dosage adopted was 6 ...200415504128
bizarre annular lesion emerging as tinea incognito.tinea incognito has first been described in 1968. the term describes a tinea infection whose clinical morphology has been modified by the application of topical corticosteroids. the clinical manifestation can masquerade a number of other dermatoses and leads to misdiagnosis of annular eruptions. we describe a patient who showed a bizarre appearance of annular, inflammatory skin lesions at the umbilical region. mycological culture yielded microsporum canis.200415504132
efficacy of pre-treatment with lufenuron for the prevention of microsporum canis infection in a feline direct topical challenge model.oral lufenuron is reportedly an effective treatment for some cats with dermatophytosis. the purpose of this study was to determine if lufenuron, when used as a pre-treatment prior to challenge exposure, would be protective against the development of infection after the direct topical application of fungal macrocondia (microsporum canis spores). three groups (n = 6/group) of juvenile cats were treated with either monthly oral lufenuron (30 or 133 mg/kg) or placebo. after 2 months of treatment, ki ...200415585010
[identification of geophilic and zoophilic dermatophytes in siblings with tinea capitis. a pathogenic factor or contamination?].two siblings of african origin presented with multiple scaling patches and alopecia on the scalp four weeks after returning from a vacation in eritrea. direct koh examination revealed fungal elements; trichophyton mentagrophytes and trichophyton terrestre were identified in the fungal culture. we discuss the putative pathogenic role of both microorganisms in causing disease. although infection with microsporum canis currently accounts for almost fifty percent of all cases of tinea capitis in ger ...200415340708
[dermatophyte infection and colonization in dogs from south santiago, chile].our main aim was to determine the dermatophyte infection and colonization prevalence in canines from south santiago, chile. we studied 241 dogs, 121 of them presented cutaneous lesions suggestive of dermatophytosis and the other 120 were free from lesions and were considered clinically healthy. dermatophytes were isolated from the lesions of 48.8% of animals with cutaneous diseases and from 5% of healthy dogs. microsporum canis was the principal species isolated with a frequency of 98.3% from de ...200315456352
isatin-derived antibacterial and antifungal compounds and their transition metal complexes.a series of isatins incorporating thiazole, thiadiazole, benzothiazole and p-toluene sulfonyl hydrazide moieties, along with their cobalt(ii), copper(ii), nickel(ii) and zinc(ii) metal complexes have been synthesized and characterized by elemental analyses, molar conductances, magnetic moments, ir, nmr and electronic spectral data. these compounds have been screened for antibacterial activity against escherichia coli, bacillus subtillis, shigella flexneri, staphylococcus aureus, pseudomonas aeru ...200415648656
use of magnetic beads to extract fungal dna.authors compare two methods of extracting dna from different fungi: the classic method with phenol/chloroform (p/c) and that with magnetic beads. both were tested on candida albicans and cryptococcus neoformans var. neoformans, belonging to the yeast group and microsporum canis, m. gypseum, trichophyton rubrum, t. interdigitale, t. ajelloi, epidermophyton floccosum, belonging to the dermatophytes group. extraction products underwent polymerase chain reaction (pcr) fingerprinting with the appropr ...200515679657
tinea capitis in diyarbakir, turkey.the incidence and types of tinea capitis in 234 children aged 1-12 referred to our laboratory with a preliminary diagnosis of tinea capitis infection in the past 5 years were investigated. tinea capitis was determined in 149 (63.7%) of these patients, of which agents grew in culture in 124 (83.2%). the most frequently isolated agents, in order of frequency, are as follows: trichophyton violaceum (43.6%), microsporum canis (37.9%), t. mentagrophytes (8.1%) and t. verrucosum (4.8%).200515679658
epidemiology of dermatomycoses in children living in northern greece 1996-2000.in the 5-years period, 1996-2000, 1045 children under 13 years old were examined for suspected dermatomycosis. in 611 cases fungi were isolated. male children were mainly affected on the scalp and body area. girls were more affected in the location of the arms and legs. there was a greater proportion of cases in the age range 2-12 years. the most prominent fungus was microsporum canis (515 cases) followed by trichophyton rubrum (34) and candida albicans (20). tinea capitis (280 cases) mainly cau ...200515679659
characteristics of dermatophytoses among children in an area south of tehran, iran.the aim of this study was to determine the prevalence and etiological agents of dermatophytoses, and also their distribution according to age, gender, and body site among children in an area south of tehran. a total of 382 children aged </=16 years suspected to have dermatophytic lesions were examined over a period of 3 years (1999-2001). the incidence rate of dermatophytoses was 6.6 per 100 000 person-years. trichophyton violaceum was the most frequent isolate (28.3%) followed by microsporum ca ...200515679663
evaluation of microsporum canis in different methods of storage.the main objective of this investigation was to evaluate different methods of storage for microsporum canis based on materials and equipment that are readily available in developing countries. we tested 32 strains of m. canis at - 20 degrees c in potato dextrose agar (pda) in its plain condition, or amended with 10% dimethyl sulfoxide or with 10% glycerol. in addition, we tested 25 degrees c storage of isolates in plain saline (0.9% nacl) and in saline covered with a mineral-oil layer. after 9 m ...200415682637
[dermatophyte species isolated from patients prediagnosed as onychomycosis and the value of fungal culture].in this study, the clinical specimens taken from 390 patients who were prediagnosed as onychomycosis have been investigated by direct microscopy and culture methods, in the mycology unit of central laboratory of kocaeli university medical faculty. twenty-one (41.2%) of the 51 microscopically positive samples revealed positive cultures for dermatophytes, whereas 32 (9.4%) samples were culture positive among the 399 samples which were microscopically negative. the most frequently isolated dermatop ...200415700670
[investigation of the inter-observer agreement rates for morphometric evaluation of the growth of microsporum canis colonies].morphometry is a newly applied method for investigation of the in-vitro growth dynamics of dermatophyte colonies. this study was undertaken to evaluate the correlation and agreement rates between the morphometric data obtained by different observers. for this purpose, five different microsporum canis growth data were evaluated by six observers. the results of the study suggested that the agreement rates among the data obtained by different observers were low (r1 = -5.3509), while the results obt ...200415700671
in vitro antifungal activity of dragon's blood from croton urucurana against dermatophytes.based on ethnobotanical approach, the dragon's blood collected from croton urucurana baill. bark (euphorbiaceae) was tested for antifungal activity against five dermatophytes by paper disk diffusion method. the minimal inhibitory concentration (mic) showing no visible fungal growth was also determined, using tube dilution technique. the test dermatophytes were tricophyton tonsurans, trichophyton mentagrophytes, trichophyton rubrum, microsporum canis and epidermophyton floccossum. the dragon's bl ...200515707783
comparison of disk diffusion method and broth microdilution method for antifungal susceptibility testing of dermatophytes.the use of the agar diffusion neo-sensitabs method to determine antifungal susceptibility of 59 isolates of dermatophytes, namely epidermophyton floccosum, microsporum canis, m. gypseum, trichophyton mentagrophytes, t. rubrum and t. tonsurans to clotrimazole (clz), itraconazole (itz) and terbinafine (tbf) is described. results obtained are compared to the minimum inhibitory concentrations (mic) determined by an adaptation of the nccls-m38-a procedure. using the diffusion method, all strains show ...200515712608
in vitro evaluation of griseofulvin against clinical isolates of dermatophytes from isfahan.fifty dermatophyte isolates, recently obtained from clinical materials, belonging to trichophyton mentagrophytes, t. verrucosum, microsporum canis and epidermophyton floccosum were examined for their susceptibility to griseofulvin. the minimum inhibitory concentration (mic) values were obtained using the modified microdilution method. all 100% tested isolates had mic geometric mean at a concentration between 0.43 and 0.95 microg ml(-1) the mic(90)s and mic(50)s were 8 microg ml(-1) and <0.25-1 m ...200415601457
antifungal activity of ocimum gratissimum towards dermatophytes.the development of more effective and less toxic antifungal agents is required for the treatment of dermatophytosis. plants and their preparations have been used as medicines against infectious diseases. extracts of ocimum gratissimum leaves were investigated for in vitro antifungal activity, using agar dilution technique against dermatophytes. the extracts (hexane, chloroform fractions, the essential oil and eugenol) produced antifungal activities against microsporum canis, m. gypseum, trichoph ...200515842332
dermatophyte infections in the ljubljana region, slovenia, 1995-2002.we studied dermatophyte infections in patients, examined in the mycological laboratory of the department of dermatology, university medical centre ljubljana during the period 1995-2002. a total of 42,494 samples were collected from 33,974 patients suspected to have dermatomycosis. dermatophytes were identified in 8286 (71.2%) positive cultures. microsporum canis was the most frequent dermatophyte isolated (46.8%), followed by trichophyton rubrum (36.7%), t. mentagrophytes var. interdigitale (7.9 ...200515842334
development of an enzyme-linked immunosorbant assay (elisa) for the serodiagnosis of canine dermatophytosis caused by microsporum canis.abstract in dogs, dermatophytosis should be considered in any case of alopecic, papular or pustular lesion. the aim of this study was to develop an enzyme-linked immunosorbant assay (elisa) as an aid in the diagnosis of canine dermatophytosis. the antigen used was a whole fungal extract obtained from an isolate of microsporum canis cultured on a liquid medium from the parasitized hair of a cat with patches of alopecia. to assess the elisa performances, sera from 18 dogs with dermatophytosis caus ...200515842540
[superficial infections caused by microsporum canis in humans and animals].dermatophytic infections caused by m. canis in humans and animals have a world wide distribution and they are zoonotic. the objective in this work was to know the frequency of m. canis infections in humans and pets. we studied our cases from january 1994 to december 2002. the human samples were obtained from a dermatological department in a general hospital and we registered the next data: age, sex, job, and affected area. the animal samples were obtained from a mycological veterinary laboratory ...200415458362
once-weekly fluconazole in children with tinea capitis due to microsporum canis. 200515868642
repetitive-sequence-pcr-based dna fingerprinting using the diversilab system for identification of commonly encountered dermatophytes.the performance of repetitive-sequence-based pcr (rep-pcr) using the diversilab system for identification of dermatophytes commonly isolated in a clinical laboratory was assessed by comparing results to those of conventional tests (colony morphology, microscopic examination of slide cultures, and, for suspected trichophyton species, use of additional media). sixty-one cultures were tested in phase 1, the feasibility portion of the study; 64 additional cultures were tested in phase 2, the validat ...200515872233
antifungal activities of six south african terminalia species (combretaceae).a serial microplate dilution method developed for bacteria was modified slightly and gave good results with several fungi. the antifungal activity of acetone, hexane, dichloromethane and methanol leaf extracts of six terminalia species (terminalia prunioides, terminalia brachystemma, terminalia sericea, terminalia gazensis, terminalia mollis and terminalia sambesiaca) were tested against five fungal animal pathogens (candida albicans, cryptococcus neoformans, aspergillus fumigatus, microsporum c ...200515894142
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