| development of an experimental model of microsporum canis infection in cats. | an experimental infection model was developed for reliable induction of microsporum canis skin infections in cats, using a defined number of macroconidia harvested from the fungus in culture. the strain of m. canis used produced highly fluorescent hairs under ultraviolet illumination. kittens 8 to 9 weeks of age (n = 6) received 10(5) macroconidia applied topically to a closely-shaved area of skin. sites were dressed with an occlusive bandage for 3 days, then grooming was restricted for an addit ... | 1994 | 9133054 |
| the use of oral terbinafine (lamisil) in children. | in an ongoing study of lamisil in children, 21 patients have so far been enrolled and preliminary data are reported in this paper. eighteen have tinea capitis and 1 has tinea corporis. so far, trichophyton tonsurans has been identified in 17 and trichophyton violaceum in 2. lamisil has so far proved to be well tolerated, efficacious and cost-effective in a 2-week course in those children with a trichophyton species. if microsporum canis is isolated, a longer course is probably indicated. lamisil ... | 1997 | 9154402 |
| in vitro evaluation of antifungal properties of 8.o.4'-neolignans. | eighteen racemic 8.o.4'-neolignans with six different substitution patterns in rings a and b, in their ketone and in their erythro and threo alcoholic forms, were evaluated for antifungal activity by the agar dilution method. only the alcohols exhibited a broad spectrum of activities against microsporum canis, microsporum gypseum, tricophyton mentagrophytes, tricophyton rubrum, and epidermophyton floccosum. (+/-)-erythro-3,4-(methylenedioxy) -7-hydroxy-1'-allyl-3',5'-dimethoxy-8.o.4'-neolignan ( ... | 1997 | 9249968 |
| [microsporum infections in hajdú-bihar county]. | mycotic infections caused by microsporum canis occurred in 237 cases between 1983-1995 in hajdú-bihar county. the disease accumulated seasonally up during the beginning of summer and the end of autumn, in particularly. children and young people had often got microsporiasis. women patients seemed to be more frequent than men. the disease in many cases, appeared on all members of families. a main factor in spreading of pathogen were apparently healthy persian cats. only few cases could be observed ... | 1997 | 9254352 |
| systemic antifungal treatment of children with terbinafine. | at present, griseofulvin is the only licensed drug for oral treatment of dermatophyte infections in children. | 1997 | 9310719 |
| dermatophytomycoses in children in rural kenya: the impact of primary health care. | in a survey of 5780 children from 13 schools in rural kisumu district (western kenya) in 1993, a prevalence rate of dermatophytomycoses of 10.1% was found. three-quarters of the affected children suffered from tinea capitis (prevalence rate 7.8%), caused by microsporum audouinii var. langeronii, trichophyton violaceum and microsporum canis. in 1994, a dermatology programme within the primary health care system was started. twelve community health workers (chws), trained in diagnosis and treatmen ... | 1997 | 9260482 |
| prevalence and characterization of microsporum canis carriage in cats. | in order to determine the prevalence and to characterize the carriage of microsporum canis in cats, different mycological examinations (including a culture obtained by hair brushing and wood's light examination) were performed on 632 animals of different origins. group 1 comprised 467 healthy pet cats belonging to veterinary students. in this group, prevalence of carriage was 2.1%: eight cats were asymptomatic transient carriers and one cat was an asymptomatic infected animal presenting discrete ... | 1997 | 9292421 |
| contact-sensing by hyphae of dermatophytic and saprophytic fungi. | contact-sensing or thigmotropism is the directional growth response of cells in relation to topographical guidance cues. thigmotropism is thought to play a major role in the location of infectable sites on plants by phytopathogenic fungi and has recently been shown to be a property of hyphae in the human pathogenic fungus candida albicans. here we show that hyphae of the dermatophytes epidermophyton floccosum, microsporum canis and trichophyton mentagrophytes reorientate their direction of growt ... | 1997 | 9292428 |
| dermatophytes isolated from domestic animals in barcelona, spain. | this retrospective study deals with the main samples studied at the mycology diagnostic service of the faculty of veterinary science of barcelona: animals with suspected dermatophytosis. over a ten-year period from 1986 to 1995, 136 dermatophytes were identified from dog and cat cultures submitted for identification and from specimens submitted for mycological examination from a variety of other domestic animals. the most frequent dermatophytes isolated were microsporum canis (55.9%), trichophyt ... | 1997 | 9335154 |
| some aspects of dermatophytoses seen at university hospital in florianópolis, santa catarina, brazil. | dematophytoses comprise mycoses which are very frequently diagnosed in the routine of clinical laboratories of florianópolis, like any other brazilian cities. however, no clinical or epidemiological studies data have been published for that city so far. to partially clarify these questions, we carried out a study on this subject on patients who sought the mycology services of hospital of federal university of santa catarina, from january 1995 to november 1996. the most prevalent dermatophyte was ... | 1997 | 9460252 |
| prevalence of undetected tinea capitis in a school survey in spain. | from october 1994 to november 1995, a prospective study aiming to detect dermatophytes on the scalp was undertaken in 5000 unselected school children aged between 3 and 16 years (mean age 8.34 years, sd +/- 3.83). thirty-two (0.64%) had dermatophytes in the scalp, 22. (0.44%) had tinea capitis and 10 were asymptomatic scalp carriers. it is important to point out that 33% of the patients with tinea capitis and 60% of the asymptomatic scalp carriers also had ringworm in other body sites. there was ... | 1997 | 9375502 |
| povidone-iodine wash solutions in the prevention of superficial fungal infections; predictive evaluation using the corneofungimetry bioassay. | prevention of superficial mycoses remains a stubborn problem. the effect of antiseptics for that purpose is largely unknown. we studied the potential fungitoxic activity of povidone iodine (pvp-i) contained in wash solutions. | 1997 | 9403279 |
| a succinylanthranilic acid ester and other bioactive constituents of jolyna laminarioides. | methyl 2-[propanamide-2'-methoxycarbonyl] benzoate, fucosterol, trans-phytol and p-formylphenol were isolated for the first time from a methanolic extract of jolyna laminarioides. methyl 2-[propanamide-2'-methoxycarbonyl]-benzoate exhibited chymotrypsin inhibitory activity and also found to be active against escherichia coli and shigella boydii. fucosterol exhibited antifungal activity against curvularia lunata, stachybotrys atra and microsporum canis. | 1997 | 9423291 |
| wood's light in microsporum canis positive patients. | in 64 patients with culturally proven microsporum canis infections, wood's light examination was performed. in 30 patients (47%) the characteristic fluorescence correlated with the cultural findings, whereas in the remaining 34 patients (53%), microsporum canis was isolated, although wood's light examination was negative. of the 30 positive and 34 negative cases eight patients of each group had been pre-treated. from the results presented, wood's light examination has a poor sensitivity in cases ... | 1997 | 9470413 |
| dermatophytes isolated from asymptomatic stray cats. | most human cases of dermatophytosis diagnosed in siena, italy, in the last 5 years have been caused by two zoophilic species: microsporum canis and trichophyton mentagrophytes. since many patients had a history of contact with apparently healthy stray cats, we examined the fur of 173 stray cats for dermatophytes. the cats were captured in different parts of siena and none of them had mycotic lesions. microsporum canis was isolated in 82 cats, trichophyton mentagrophytes in three and microsporum ... | 1997 | 9470415 |
| prevalence and aetiology of dermatophytoses in isfahan, iran. | in this study the prevalence and causative agents of dermatophytoses in isfahan, a large province of iran, were determined. of 16,578 clinically suspected cases 13.3% were affected with dermatophytoses. lesions of tinea capitis were the most prevalent clinical type of dermatophytoses (54.1%), followed by tinea corporis (23.8%) and tinea pedis (8.9%). trichophyton verrucosum was the most frequent causative agent (32.8%), followed by epidermophyton floccosum (17.6%), t. mentagrophytes (16.2%) and ... | 1997 | 9476518 |
| tinea capitis in children in the district of cagliari, italy. | between 1986 and 1995, 4104 children were observed in the clinic of dermatology in cagliari, italy. three hundred and thirty-six children (8.2%), 188 boys and 148 girls, aged 1 month to 13 years, were affected by tinea capitis. microsporum canis was detected in 278 cases (82.7%) and trichophyton mentagrophytes in 58 cases (17.3%). systemic treatment with 20-25 mg kg-1 day-1 griseofulvin led to complete recovery in 30-40 days. none of the patients relapsed. the epidemiology of the infection was a ... | 1997 | 9476495 |
| griseofulvin and terbinafine in the treatment of tinea capitis in children. | to compare the effectiveness of griseofulvin and terbinafine in the treatment of tinea capitis in children. | 1998 | 9539918 |
| itraconazole susceptibility of feline isolates of microsporum canis. | the in vitro activity of itraconazole against microsporum canis was evaluated with 38 feline isolates. based on the observed minimum inhibitory concentrations it can be concluded that the drug could be effective in the therapy of cats affected by m. canis ringworm. | 1997 | 9476516 |
| [two cases of tinea capitis with different clinical courses]. | we report cases of two 4-year-old boys with tinea capitis who attend the same daynursery. clinically, on the first visit both lesions were a superficial type, however we initiated treatment with a dose of 50 mg/day of oral itraconazole. althougth the lesion of case 2 improved after 11 weeks of treatment, case 1 developed to kerion celsi and required continued treatment for 22 weeks for cure. microsporum canis was isolated from the hairs of both cases and mic of itraconazole against both isolates ... | 1998 | 9580037 |
| [dermatophytes isolated in our clinics. 5-year-study in zaragoza]. | this review summarizes the different species of dermatophytes isolates in our laboratory between 1991 and 1995. we describe the clinical forms and establish the distribution over this period of time. | 1997 | 9580210 |
| butenafine. | butenafine is a new antifungal agent with primary fungicidal activity against dermatophytes such as trichophyton mentagrophytes, microsporum canis and trichophyton rubrum which cause tinea infections. 14c-labelled butenafine (approximately 30 micrograms/g tissue) was found within guinea-pig dorsal skin 24 hours after topical application. most of the drug was distributed into the epidermis including the horny layer. small amounts were found in the dermis, probably transported via sebaceous glands ... | 1998 | 9530545 |
| antimicrobial effects of aqueous plant extracts on the fungi microsporum canis and trichophyton rubrum and on three bacterial species. | aqueous extracts of 10 plants were tested for their ability to inhibit trichophyton rubrum and microsporum canis, the aetiological agents of dermal fungal infections in humans. these extracts were also evaluated for their activity against some bacteria. aqueous extracts from the leaves of inula viscosa produced detectable antifungal activity against these dermatophytes. | 1998 | 9489036 |
| [mycetomas caused by microsporum canis. report of one case]. | we report an eight years old boy presenting with a pyogenic granuloma of the scalp, generalized alopecia, descamative plates in the neck, trunk and limbs and nail involvement. cultures for fungus of all these lesions disclosed microspore canis. the patient was treated with oral griseofulvin, miconazole and topical tolnaftate. five years later and after several incomplete treatments, the patient returns with a fistulous mass of 15 x 8 cm in the dorsal area whose culture revealed microspore canis. ... | 1997 | 9567397 |
| prevalence of undetected tinea capitis in a prospective school survey in madrid: emergence of new causative fungi. | from october 1994 to december 1996, a prospective study was undertaken in 10,000 unselected school children in madrid, aged between 2 and 16 years (mean +/- sd 8.5 +/- 3.6 years). fifty-two (0.52%) (including 13 immigrants from africa) had dermatophytes in the scalp: 33 (0.33%) (including 10 immigrants from africa) had tinea capitis and 19 were scalp carriers. almost half of the symptomatic cases were caused by trichophyton tonsurans (12 of 33 cases) and microsporum canis (16 of 33 cases). t. to ... | 1998 | 9640375 |
| microsporum canis infection of the penis. | | 1997 | 9582492 |
| kerion celsi: a clinical epidemiological study. | we present a case record of patients with kerion celsi observed in the clinic of dermatology, university of cagliari (italy) from 1981 to 1995. altogether, 31 children (18 male and 13 female) with an age range of 40 days to 12 years were studied. in all cases the lesions were confined to the scalp. in 10 cases the disease developed as such, while in 21 patients it represented the inflammatory evolution of tinea capitis secondary to incongruous topical treatment. microsporum canis was isolated in ... | 1998 | 9670770 |
| the in vitro and in vivo production of a 31.5-kd keratinolytic subtilase from microsporum canis and the clinical status in naturally infected cats. | microsporum-canis-infected cats, especially the asymptomatic infected ones, are mainly responsible for the zoonotic disease. the important variability of the clinical signs in cats is poorly understood. recently, a 31.5-kd keratinolytic subtilase was found to be a putative virulence factor. | 1998 | 9669125 |
| identification of clinical isolates of microsporum canis and m. gypseum by random amplification of polymorphic dna (rapd) and southern hybridization analyses. | clinical isolates of microsporum canis and m. gypseum from humans, dogs and cats were examined by random amplification of polymorphic dna (rapd) and southern hybridization analyses. the rapd band patterns of six clinical isolates of m. canis were identical to those of standard strains of arthroderma otae. of nine clinical isolates of m. gypseum seven and two isolates showed rapd patterns identical to those of standard strains of a. gypseum and a. incurvatum respectively. southern blot analysis u ... | 1998 | 9670766 |
| [zoophilic dermatophytes as epizoonoses pathogens and their significance to dermatology]. | different dermatophytes occurring primarily in animals may be transmissible to man and produce human disease; such zoophilic fungi should be considered a possible cause of skin lesions of unclear origin. several species including trichophyton verrucosum, trichophyton mentagrophytes and microsporum canis may infect human skin, causing a variety of signs and symptoms. people who have close contact to infested cattle or cats are more often exposed to fungal infections. certain professions, such as ... | 1998 | 9675572 |
| a survey of dermatophytes isolated from human patients in the united states from 1993 to 1995. | a survey of dermatophytes, isolated from human patients seeking medical attention, was conducted for the years 1993 to 1995. data were collected from 23 states throughout the continental united states and the district of columbia and from 44 to 45 laboratories. these data were compared with the results of two earlier surveys (1979 to 1981 and 1985 to 1987). in contrast to the earlier surveys trichophyton tonsurans became the most frequently isolated dermatophyte (44.9%) followed by t. rubrum (41 ... | 1998 | 9704838 |
| fungal flora in human skin and skin appendages infections in the region of lódź, poland. | in the years 1987-95, 3550 patients with mycotic skin infections were divided into two groups: a group of 2282 (64.3%) subjects with dermatophytosis and a group of 1268 (35.7%) subjects with other fungal infections. among dermatophytes the most common infectious agent was trichophyton mentagrophytes (33%), followed by t. rubrum (30%) and microsporum canis (11%). a total of 17% of all infections were caused by candida sp. | 1998 | 9715642 |
| [dermatomycosis caused by trichophyton verrucosum in mother and child]. | in recent years, there has been an epidemiological renaissance of zoophilic dermatophytoses caused by a variety of factors. at present, the most important causative organisms are microsporum canis, trichophyton mentagrophytes var. granulosum and, as in the present case, trichophyton verrucosum. these are formerly notifiable pathogens which are highly virulent and contagious. the example of an extensive, originally unrecognized tinea corporis et faciei in mother and child presented here shows the ... | 1998 | 9715387 |
| differentiation of microsporum species by random amplification of polymorphic dna (rapd) and southern hybridization analyses. | molecular characterization of 18 species belonging to the genus microsporum isolated from human and animal dermatophytosis was carried out by random amplification of polymorphic dna (rapd) and southern hybridization analyses. all of these 18 microsporum species showed different band patterns specific to each species in rapd analysis. southern hybridization analysis using c3 probe derived from a rapd band from arthroderma otae, teleomorph of m. canis, revealed distinct bands in 14 of the 18 micro ... | 1998 | 9715638 |
| epidemiological study of tinea capitis in schoolchildren in the nablus area (west bank). | a study of tinea capitis was carried out during the period january-june 1996 in 7525 primary schoolchildren aged 6-14 years comprising 4050 boys and 3475 girls in the nablus district in the palestinian area. fourteen primary schools located in rural, urban and refugee camp areas were surveyed in this study. seventy-five (1.0%) mycologically proven cases of tinea capitis were detected. the incidence was higher in schools in rural areas (1.9%) than in refugee camps (1.1%) or urban areas (0.4%). al ... | 1998 | 9715641 |
| relapsing tinea capitis by microsporum canis in an adult female renal transplant recipient. | scalp ringworm is very uncommon in adults. the occurrence and the atypical clinical course of this unusual dermatophytosis in a female renal transplant recipient are described. furthermore, the prevalence and the clinical features of superficial fungal infection in renal transplant recipients are reviewed. as immunosuppression enhances the risk of antifungal therapy failure, more prolonged treatment and careful follow-up are necessary to obtain complete recovery from any dermatophytosis in renal ... | 1998 | 9730705 |
| [dermatophytosis in the greater resistencia area, chaco province, argentina]. | epidemiological characteristics of dermatophytoses in the metropolitan area of resistencia city are described. hair fragments, skin, scalp or nail scrapings were collected from 3.507 persons with dermatological symptoms of probable fungal origin. the mycological studies were performed by three mycological laboratories, one from a university institute and two from private laboratories. direct microscopic examinations showed fungi in 39.66% of samples, while the recovering of dermatophytes from cu ... | 1998 | 9744034 |
| itraconazole oral solution for the treatment of tinea capitis. | twenty-seven children (12 boys, 15 girls, age range 3-11 years, weight range 10-40 kg) were treated with itraconazole oral solution 10 mg/ml given as pulse therapy for tinea capitis. the dosage regimen was 3 mg/kg per day given once daily in a fasting state with each pulse lasting 1 week. the first two pulses were separated by a 2-week off-drug period, and the second and third pulses had a 3-week period without drug between them. for each patient a second and third pulse were administered if the ... | 1998 | 9764158 |
| comments on microsporum canis. | | 1998 | 9776843 |
| increased incidence of trichophyton tonsurans tinea capitis in ontario, canada between 1985 and 1996. | in canada, since the 1990s, trichophyton tonsurans has emerged as the main cause of tinea capitis. prior to this the more common agents were t. verrucosum, microsporum canis and m. audouinii. over the past few years the incidence of t. tonsurans has increased such that in 1985 and 1996 the cases of mycologically confirmed tinea capitis due to t. tonsurans were 9% and 76%, respectively. the epidemic of t. tonsurans has reduced the role of wood's lamp in diagnosis of tinea capitis. the age distrib ... | 1998 | 9776814 |
| efficacy of oral administration of itraconazole to cats with dermatophytosis caused by microsporum canis. | to determine efficacy of orally administered itraconazole in cats with dermatophytosis caused by microsporum canis. | 1998 | 9776995 |
| [scanning electron microscope sudy of the morphology of fungi isolated from patients at the aristide la dantec hospital in dakar, senegal]. | in order to improve the identification of fungi usually isolated among some patients at dantec hospital, a study by scanning electron microscopy has been carried out. it deals with four species of yeasts (candida albicans, candida parapsilosis, rhodotorula rubra sacharomyces cerevisiae) six species of dermatophytes (trichophyton rubrum, trichophyton soudanense, trichophyton interdigitale, microsporum canis, trichophyton violaceum, microsporum audouinii); two species of mildew, (aspergullus flavu ... | 1996 | 9827085 |
| terbinafine (lamisil) therapy for microsporum canis scalp ringworm. | | 1998 | 9861751 |
| parasitic relationship between microsporum canis and the cat. | cats are often cited as reservoirs of m. canis but it is questionable whether m. canis is part of the resident flora of the cat's skin and hair or only a transient organism. studies indicate that m. canis is most often isolated from cats at risk of infection or exposure from other infected cats or from a contaminated environment. many more cats are culture-positive for m. canis than have dermatophytosis. culture isolation alone is not an indication of dermatophytosis; the diagnosis of dermatophy ... | 1998 | 9988517 |
| isozyme variation within and among populations of microsporum species. | isozyme variation among 54 isolates of microsporum canis, 18 microsporum cookei isolates and two diheterospora isolates were studied using starch gel electrophoresis. of eight enzymes examined, four were polymorphic (est, g6p, mdh and pep), having from two to four electrophoretic forms. within each species, consistent and reproducible isozyme patterns of the eight enzyme systems were obtained. phenotypic diversity (h) in m. canis was higher than in m. cookei (h = 0.459 and h = 0.408 respectively ... | 1998 | 9919894 |
| tinea capitis dermatophytes: susceptibility to antifungal drugs tested in vitro and in vivo. | tinea capitis is a worldwide-spread infection of the scalp caused by dermatophytes and is predominantly seen in children. the clinical manifestations range from mild scaling lesions to widespread alopecia or highly inflammatory suppurating lesions. terbinafine and itraconazole seem to be promising therapies with shorter treatment durations than griseofulvin. | 1998 | 9873175 |
| [dermatomycosis in human and animals]. | dermatomycosis including dermatophytosis, sporotrichosis and cryptococcosis commonly occurs in humans and animals all and are considered to be zoonotic diseases. recently, human cases of dermatophytosis transmitted from animals are increasing in number due to changes in the environments of human and animal life. three species of dermatophytes, microsporum canis, trichophyton mentagrophytes and t. verrucosum are the most important pathogens from animal to human, respectively. therefore, it is nec ... | 1999 | 9929576 |
| isozyme variation of microsporum canis and m. cookei from new zealand. | fifty-four isolates of microsporum canis (arthroderma otae) from humans, cats and dogs obtained from auckland, palmerston north and wellington, new zealand and 18 m. cookei and two diheterospori spp. from soils were examined for variation using eight isozyme loci. m. canis isolates were from infected and non-infected cases. isozyme analysis separated the three species which were further subdivided into electrophoretic types (ets). clustering analysis using normalized percentage disagreement (ptc ... | 1998 | 10075493 |
| miconazole/chlorhexidine shampoo as an adjunct to systemic therapy in controlling dermatophytosis in cats. | a 2 per cent miconazole/2 per cent chlorhexidine shampoo was used in two groups of persian cats infected with microsporum canis. in the first group, the cats were treated with griseofulvin alone while, in the second, griseofulvin was used with the shampoo. the clinical signs of the cats were scored on a scale of 1 to 4 for seborrhoea, ease of epilation of hair and the extent of primary lesions, to try to give an overall impression of hair coat condition. the speed of resolution of the infection ... | 1999 | 10340245 |
| histopathological pattern and humoral immune response to a crude exo-antigen and purified keratinase of microsporum canis in symptomatic and asymptomatic infected cats. | in order to understand better the mechanisms involved in the diverse clinical patterns in microsporum canis-infected cats, the histopathological features were compared in symptomatic and asymptomatic infected cats. additionally, the igg immune response to a crude exo-antigen and purified keratinase of m. canis was studied by elisa in cats of various clinical and mycological status. acute and subacute perifolliculitis and folliculitis occurred more frequently in symptomatic than asymptomatic cats ... | 1999 | 10200928 |
| short duration treatment with terbinafine for tinea capitis caused by trichophyton or microsporum species. the study group. | thirty-five patients with mycologically proven scalp infections were enrolled in a randomized, double-blind clinical trial with oral terbinafine (dose adjusted according to patient weight) for either 1 or 2 weeks. patients were observed for 12 weeks; after 4 weeks, non-responders were offered an additional 4 weeks of treatment followed by a second observation period. the causative organisms were microsporum canis (n = 12), trichophyton tonsurans (n = 12) and other trichophyton spp. (n = 11). the ... | 1999 | 10233270 |
| purification and characterization of a 315 kda keratinolytic subtilisin-like serine protease from microsporum canis and evidence of its secretion in naturally infected cats. | a keratinolytic protease, secreted as the major component by a feline clinical isolate of microsporum canis cultivated in a minimal medium containing cat keratin, was purified by affinity chromatography on bacitracin agarose and gel filtration. the apparent molecular mass of the enzyme was 31.5 kda and the pi was 11.8. the enzyme was not glycosylated and its first 15 n-terminal amino acids showed numerous similarities with other fungal subtilisins. the optimum ph was around 9 while inactivation ... | 1998 | 10206750 |
| phylogeny and taxonomy of the family arthrodermataceae (dermatophytes) using sequence analysis of the ribosomal its region. | the internal transcribed spacer (its) region, covering the its1, its2 and 5.8s ribosomal dna was used to evaluate phylogenetic relationships within the fungal family arthrodermataceae. sequences of variable length, ranging between 522 and 684 base pairs were aligned. an unrooted consensus tree based on parsimony analysis showed trichophyton to be polyphyletic, and microsporum to be paraphyletic. non-monophyly of these two genera is in conflict with traditional classification. but this relation i ... | 1999 | 10361266 |
| humoral and cellular immune response to a crude exo-antigen and purified keratinase of microsporum canis in experimentally infected guinea pigs. | in order to understand better the host-parasite relationship and to compare with previous observations in microsporum canis naturally infected cats, the humoral and cellular immune responses to both a crude exo-antigen and a 31.5 kda purified keratinase were evaluated in 12 m. canis experimentally infected guinea pigs. humoral and cellular responses were assessed by elisa from days 0 to 56 postinfection (pi) and by measurement of delayed-type hypersensitivity (dth) responses on days 14 and 57 pi ... | 1999 | 10361268 |
| tinea capitis: an overview with emphasis on management. | tinea capitis is perhaps the most common mycotic infection in children. in north america the epidemiology of tinea capitis has changed so that trichophyton tonsurans now predominates over micro-sporum audouinii. with this transition the utility of the wood's light for diagnosis has been reduced since t. tonsurans infection is wood's light negative. griseofulvin has been the mainstay of therapy for the last 40 years. the newer antifungal agents-itraconazole, terbinafine, and fluconazole-appear to ... | 1999 | 10383772 |
| [the etiology and epidemiology of dermatophytoses in goiânia, go, brazil]. | dermatophytoses are superficial infections that may lead to lesions of keratinized tissues, like skin, hair and nails. a total of 6068 individuals from goiânia, go, with suspected dermatophytic lesions were examined over a period of five years (1993-1997) in order to determine the incidence and etiology of dermatophytosis. material collected from different body parts was submitted to direct microscopic examination using koh, cultured in sabouraud agar and microscopically examined for colony morp ... | 1999 | 10495665 |
| tinea capitis in children in northern greece during the period 1981-1995. | in our 15 years of investigation in northern greece, the predominant organism producing tinea capitis in children was found to be the zoophilic microsporum canis (494 strains) which is a common saprophyte of the hair of pets, especially cats. the high percentage of cases with m. canis (97%), in contrast to zoophilic fungi (3%), is probably due to the increased contact of children with pets. the small number of infections with anthropophilic fungi (41 strains) is attributed to good hygienic condi ... | 1999 | 10424103 |
| tinea capitis in basrah, iraq. | tinea capitis is the most common type of dermatophytosis constituting 35.2% (173/491) of all cases of dermatophytosis seen at two out-patients dermatological clinics of the basrah general hospital and at two private dermatological clinics between october 1994 and december 1995. males were more commonly affected than females represented by 60 and 40%, respectively. out of 173 mycologically positive cases, 143 specimens were culture-positive, represented by five dermatophyte species; trichophyton ... | 1999 | 10424105 |
| dermatophytic granuloma caused by microsporum canis in a heart-lung recipient. | we present a case of dermatophytic granuloma caused by microsporum canis in a heart-lung recipient. this 66-year-old man was seen for erythematous pustules and papules on the forearm. the diagnosis was suspected after histological examination showing an inflammatory infiltrate in the upper dermis with giant cells containing intracytoplasmic fungal elements. cultures of the skin biopsy confirmed the diagnosis identifying m. canis. our case emphasizes the possibility of deep dermatophytic infectio ... | 1999 | 10393464 |
| detection by elisa of the humoral immune response in rabbits naturally infected with trichophyton mentagrophytes. | an indirect enzyme linked immunosorbent assay (elisa) was developed and its diagnostic potential evaluated for rabbits infected by trichophyton mentagrophytes. within-run and between-run coefficient of variance varied from 2.3 to 7.7% and from 5.9 to 8.5%, respectively, indicating satisfactory reproducibility of the elisa. there was no significant cross-reaction with antigens of microsporum canis, malassezia pachydermatis and aspergillus fumigatus. the level of specific igg to trichophyton menta ... | 1999 | 10591499 |
| tinea capitis in siena, italy. an 18-year survey. | in the period 1980-1998, 181 cases of tinea capitis out of a total of 1480 cases of dermatophytosis were observed in siena, italy; 176 cases were children (mean age 6 years, range 45 days to 14 years; 91 boys, 85 girls) and the other five cases were postmenopausal women. diagnosis was made on the basis of culture which was positive in 179 cases, and direct microscopic observation which was positive in 155 of 179 cases. in two cases, positive direct microscopic results were not confirmed by the c ... | 1999 | 10592701 |
| case report. tinea corporis purpurea. | we report a case of tinea corporis purpurea localized to a calf in a 36-year-old woman. the patient, who was also affected by mild superficial venous insufficiency of lower limbs, complained of intense pruritus. microsporum canis was the aetiological agent. clinically atypical varieties of tinea corporis were sometimes reported in the literature, particularly in hiv-positive patients, although they are uncommon in immunocompetent patients; in particular, tinea corporis purpurea is very rare. | 1999 | 10592707 |
| the use of itraconazole to treat cutaneous fungal infections in children. | cutaneous mycoses such as tinea capitis, onychomycosis and some cases of tinea corporis/cruris, and tinea pedis/manus require oral antifungal therapy. there is relatively limited data regarding the use of the newer oral antifungal agents, e.g. itraconazole, in the treatment of these mycoses in children. | 1999 | 10592406 |
| in vitro evaluation of antifungal properties of phenylpropanoids and related compounds acting against dermatophytes. | thirty-four arylpropanoids and related compounds were evaluated in vitro for antifungal properties. among them, 22 phenyl-, 4 naphthyl-, and 4 phenanthrylpropanoids; naphthalene; phenanthrene; and 2-chloro-1-hexyl-1-propanone were tested against dermatophytes by the agar dilution method. alpha-halopropiophenones exhibited a broad spectrum of activities against microsporum canis, microsporum gypseum, trichophyton mentagrophytes, trichophyton rubrum, and epidermophyton floccosum, with mic values b ... | 1999 | 10543891 |
| identification of dermatophytes by fourier transform infrared spectroscopy (ft-ir). | fourier transform infrared spectroscopy is an established method in the routine diagnosis of various micro-organisms, including bacteria and yeasts, on a species level. its possible value in the diagnostics of dermatophytes was analysed using three clinical isolates each of the three most frequently found species, namely trichophyton rubrum, trichophyton mentagrophytes and microsporum canis. the results encourage further work to establish a library which would allow the use of this method in the ... | 1999 | 10592695 |
| comparison of terbinafine and griseofulvin in the treatment of tinea capitis. | griseofulvin has been used for many years in the treatment of tinea capitis. increase in resistance to this medication has led to a search for new therapeutic alternatives. | 2000 | 10607324 |
| risk factors for lung cancer among northern thai women: epidemiological, nutritional, serological, and bacteriological surveys of residents in high- and low-incidence areas. | lung cancer incidence among northern thai women is one of the highest in asia (an annual age-adjusted incidence rate of 37.4 per 100,000), and the incidence rate significantly differs by geographical districts. therefore, we conducted a comparative study of women living in the sarapee area, which showed the highest (crude incidence rate, 40.9), and the chom tong area, which had one of the lowest incidence rates (8.5) in chiang mai province, despite the two areas' geographical and cultural closen ... | 1999 | 10622527 |
| survey on the epidemiology of microsporum canis infections in crete, greece over a 5-year period. | microsporum canis is a frequent cause of tinea capitis and tinea corporis in europe and especially in the mediterranean area. objective this study was undertaken to examine the epidemiologic features of all cases of m. canis infections recorded in crete, greece, during a 5-year period (1994-1998). | 2000 | 10651959 |
| [dermatophytes from animals]. | dermatophytes from animal dermatophytoses were investigated, especially for their teleomorphs and molecular characteristics. microsporum canis, m. equinum, m. gypseum, m. nanum, trichophyton equinum, t. mentagrophytes complex, t. rubrum and t. verrucosum were isolated as the etiological agents of animal ringworm in japan. they were morphologically and biochemically identified and their perfect states were examined. the teleomorph of m. canis was first obtained and reported as nanizzia otae in 19 ... | 2000 | 10660635 |
| isolation of total rna from dermatophytes. | we report a method for the preparation of total rna from the anthropophilic dermatophyte trichophyton rubrum. to generate large quantities of mycelia, the fungus was grown in liquid culture medium. the harvested mycelial mass was ground to a fine powder in liquid nitrogen and homogenized in guanidine isothiocyanate buffer followed by ultracentrifugation of the obtained suspension through a caesium chloride gradient. analysis of the prepared rna showed two prominent ribosomal rna (rrna) bands of ... | 1999 | 10680437 |
| epidemiology of dermatomycoses of humans in central poland. part v. tinea corporis. | the total number of dermatophytoses (7393) included 2204 (29.8%) cases of tinea glabrosa. etiological factors in descending order were: microsporum canis (23.5%), trichophyton mentagrophytes var. granulosum (21.6%), trichophyton rubrum (17.8%), trichophyton tonsurans (10.4%), epidermophyton floccosum (7.7%), t. mentagrophytes var. quinckeanum (6.0%), microsporum gypseum (5.3%), trichophyton violaceum (3.7%), t. mentagrophytes var. interdigitale (2.3%), microsporum equinum (0.7%), trichophyton ve ... | 1999 | 10680444 |
| antifungal activity of plant extracts against dermatophytes. | the aqueous extracts (15 micrograms ml-1 medium) of 22 plants used in folkloric medicine in palestine were investigated for their antifungal activity and minimum inhibitory concentrations (mics) against nine isolates of microsporum canis, trichophyton mentagrophytes and trichophyton violaceum. the extract of the different plant species reduced colony growth of the three dermatophytes by 36 to 100% compared with the control treatment. antimycotic activity of the extract against the three dermatop ... | 1999 | 10680445 |
| fungal flora on cutaneous and mucosal surfaces of cats infected with feline immunodeficiency virus or feline leukemia virus. | to compare cutaneous and mucosal mycoflora in cats infected with fiv or felv with that in noninfected cats. | 2000 | 10685687 |
| prevalence of dermatophytoses in the zarqa district of jordan. | a total of 350 clinically suspected cases of dermatomycoses were examined for causative fungi during july 1997 to september 1998. mycotic infection was demonstrable by microscopy and culture in 199 (56.8%) cases. the most common superficial mycotic infections were tinea pedis (35.2%) followed by tinea capitis (23.1%), tinea unguium (21.6%) and tinea corporis (10.6%). most of the infected patients were 1-9, 20-29 and 30-39 years old. men were mainly infected with tinea cruris and tinea pedis, whi ... | 1999 | 10685449 |
| molecular and conventional taxonomy of the microsporum canis complex. | the validity of taxa around microsporum canis was evaluated by a combination of phenetic and molecular methods. morphological and physiological features were compared with results of sequencing of the internal transcribed spacer (its) region of the ribosomal operon, polymerase chain reaction (pcr) fingerprinting and amplified fragment length polymorphism (aflp) analysis. the seven species investigated seem to be infraspecific taxa and were reclassified or synonymized as m. canis (teleomorph: art ... | 2000 | 10817231 |
| once weekly fluconazole is effective in children in the treatment of tinea capitis: a prospective, multicentre study. | in an open, multicentre evaluation carried out in brazil, canada and south africa we have demonstrated that fluconazole 8 mg kg-1 once weekly is effective in tinea capitis caused by trichophyton and microsporum species. there were 61 children, aged (mean +/- se) 5.0 +/- 0.3 years; weight (mean +/- 5.6) 20.0 +/- 0.9 kg; 41 males, 20 females; one asian, 57 black, one caucasian and two hispanic. the organisms were trichophyton violaceum (33 patients), t. tonsurans (11) and microsporum canis (17). t ... | 2000 | 10809856 |
| efficacy of chlorhexidine against some strains of cultured and clinically isolated microorganisms. | the efficacy of chlorhexidine digluconate was determined against some strains of collected and clinically isolated bacteria and fungi. the efficacy was evaluated either by calculating a minimum inhibitory concentration (mic) or by efficacy trials according to the guidelines of the european committee for standardization. the mic values of chlorhexidine for staphylococcus aureus, microsporum gypseum, microsporum canis and trichophyton mentagrophytes were 0.625 microg/ml, 12.5 microg/ml, 50 microg/ ... | 2000 | 10836268 |
| tinea capitis in benghazi, libya. | tinea capitis is a worldwide problem. it affects mainly school age children. late detection and improper treatment of the inflammatory type of this disease may result in disfigurement and permanent alopecia. the objectives of this study were to determine the prevalence, clinical types, and causative species of tinea capitis in benghazi, libya. | 2000 | 10809973 |
| an evaluation of the in vitro activity of terbinafine. | terbinafine has previously been shown to be highly active against dermatophytes and many other filamentous fungi. however, its activity against yeasts is controversial, with earlier reports suggesting that it has low activity, while more recent studies demonstrated that terbinafine is effective against yeasts. in this study, the in vitro activity of terbinafine was evaluated against a broad range of fungal isolates. we examined the susceptibility of 100 yeast strains (10 species including candid ... | 2000 | 10817232 |
| inhibitors of the fungal cell wall. synthesis of 4-aryl-4-n-arylamine-1-butenes and related compounds with inhibitory activities on beta(1-3) glucan and chitin synthases. | as part of our project devoted to the search for antifungal agents, which act via a selective mode of action, we synthesized a series of new 4-aryl- or 4-alkyl-n-arylamine-1-butenes and transformed some of them into 2-substituted 4-methyl-tetrahydroquinolines and quinolines by using a novel three-step synthesis. results obtained in agar dilution assays have shown that 4-aryl homoallylamines not possessing halogen in their structures, tetrahydroquinolines and quinolines, display a range of antifu ... | 2000 | 10819157 |
| case reports. pityriasis amiantacea as manifestation of tinea capitis due to microsporum canis. | we report three patients, two infants and an adult, in whom their tinea capitis clinically appeared as pityriasis amiantacea. the mycological studies showed infection due to microsporum canis in all cases. correct diagnosis as well as adequate antimycotic chemotherapy of this atypical manifestation of tinea capitis remain a challenge to the clinician. epidemiological aspects must be regarded also. | 2000 | 10838857 |
| white superficial onychomycosis of a toenail due to microsporum canis. | | 2000 | 10877147 |
| antifungal effects of hydrolysable tannins and related compounds on dermatophytes, mould fungi and yeasts. | a series of hydrolysable tannins and related compounds was evaluated for antifungal activities against filamentous fungi (epidermophyton floccosum; microsporum canis; microsporum gypseum; trichophyton mentagrophytes; trichophyton rubrum; trichophyton tonsurans; trichophyton terrestre; penicillium italicum; aspergillus fumigatus; mucor racemosus; rhizopus nigricans) and opportunistic yeasts (candida albicans; candida glabrata; candidata krusei; cryptococcus neoformans), using the agar dilution me ... | 2000 | 10928561 |
| microsporum canis associated with otitis externa in a persian cat. | | 2000 | 10955895 |
| tinea capitis. | tinea capitis is a common dermatophyte infection of the scalp in children. dermatophytes are classified into three genera; tinea capitis is caused predominantly by trichophyton or microsporum species. on the basis of host preference and natural habitat, dermatophytes are also classified as anthropophilic, geophilic and zoophilic. the etiological agents of tinea capitis usually fall in the first and last categories. in north america, tinea capitis is now predominantly due to trichophyton tonsuran ... | 2000 | 10975696 |
| detection of microsporum canis in the skin scrapings and hairs of dogs with dermatophytosis based on sequences of the chitin synthase 1 gene. | in the present study, to confirm microsporum canis infection rapidly, we detected the chitin synthase gene 1 (chs1) gene of m. canis in the hair and skin samples of four dogs with dermatophytosis. amplification of the dnas in the four samples with chs1 primers yielded fragments of about 620-bp. nucleotide sequence analysis of the chs1 gene fragments from samples and a reference strain of m. canis gene showed more than 99% similarity. the method presented in this study can rapidly detect the dna ... | 2000 | 10981834 |
| nosocomial ringworm in a neonatal intensive care unit: a nurse and her cat. | an outbreak of nosocomial ringworm involved five infants in a neonatal intensive care unit. the index case was a nurse infected with microsporum canis by her cat. after standard infection control measures were initiated, the outbreak was resolved successfully by an interdisciplinary professional collaboration of physician and veterinary dermatologists and infection control personnel. | 2000 | 11001268 |
| the development of the method for the determination of terbinafine in cat's plasma and hair. | clinical investigations of terbinafine indicate its high treatment activity against infections by several dermatophytes. its efficiency was tested also in the treatment of microsporosis in cats. the distribution of terbinafine in cat's plasma and hair is important for the identification of the drug efficiency. a fast and reliable reversed-phase high performance liquid chromatographic method with appropriate sample preparation has been developed. reliability, good reproducibility and low detectio ... | 2000 | 11005657 |
| [microsporum canis mycetoma of the scalp]. | mycetoma is a chronic subcutaneous tumefaction with presence of grains or granules. etiological agents include bacteria or filamentous fungi. mycetoma due to dermatophytes is uncommon, mainly occurring in africa. to our knowledge, no case has been reported in the west indies. only two observations of micosporum canis mycetoma in humans have been reported in the literature. we report a third case of mycetoma of the scalp caused by this fungus. | 2000 | 11011164 |
| optimizing the therapeutic approach in tinea capitis of childhood with itraconazole. | tinea capitis is the most common dermatophytosis of childhood with increasing incidence. whereas griseofulvin is considered by many as the mainstay of treatment, newer oral antifungal agents, including fluconazole, itraconazole and terbinafine have demonstrated higher efficacy, resulting in shorter treatment durations. | 2000 | 11069511 |
| [dermatophytoses due to domestic animals]. | dermatophytoses are superficial skin infections due to dermatophytes which are filamentous fungi. some dermatophytes can be hosted by domestic animals. in belgium, microsporum canis, trichophyton (t.) mentagrophytes variety mentagrophytes, t. verrucosum and t. equinum are zoophilic species capable of infecting humans. animals, clinical aspects in humans and the investigations needed will be reviewed. treatment should target animal and patient but also limit the spread of the infection. topical t ... | 2000 | 11068472 |
| [molecular biological methods and their consequences in taxonomy and diagnosis of dermatophytes]. | trichophyton rubrum, t. mentagrophytes, t. verrucosum, microsporum canis, m. gypseum and epidermophyton flocoosum represent the cause of human dermatomycoses isolated most often at the university hospital of dermatology in graz, austria, between 1991 and 1998. so far, identification was mainly based on the cultivation of fungal isolates on special media as well as on the analysis of their microscopic characters. restriction enzyme length polymorphisms (rflps) were now used to identify these huma ... | 2000 | 11098620 |
| [urban and rural mycozoonoses]. | the main mycozoonoses are due to specific dermatophytes which are pathogens for man and animals. contamination occurs most often after close contact with the animal showing clinical lesions or with inapparent carriage only. the contaminated environment also participates to the mycozoonotic epidemics. interhuman transmission is more rarely encountered. young children before puberty are most receptive to the disease. the main urban mycozoonosis is due to microsporum canis transmitted by dogs and c ... | 2000 | 11195712 |
| [epidemiology, clinic and treatment of dermatomycoses caused by zoophilic dermatophytes] . | in the last 50 years the spectrum of agents of dermatophytoses changed. the change is remarkable especially in the case of zoophilic dermatophytes. microsporum canis has displaced trichophyton verrucosum. in the period from 1966 to 1970 2822 dermatophytoses were registered as occupational dermatoses in the former german democratic republic. in the following years the number of these diseases was continuously reduced, between 1981 and 1985 down to 995 cases. this reduction is predominantly the re ... | 2000 | 11098618 |
| characterization of an extracellular keratinase from microsporum canis. | extracellular keratinase (ekase) 48-, 34- and 31.5-kda polypeptides, which were isolated from microsporum canis and examined by immunoblotting reacted with a monoclonal antibody against ekase of m. canis. we analyzed the amino acid and determined the first 17 amino acid nh2-terminal sequences of the 48-, 34- and 31.5-kda polypeptides. these polypeptides had a high aspartic acid, glycine and alanine content, respectively. the first 17 amino acid residues of the 34-kda polypeptide were homologous ... | 2000 | 11064325 |
| tinea faciei due to microsporum canis abscess formation. | superficial dermatophyte infections are common in children; however, complications are encountered rarely. we describe a child with tinea faciei caused by microsporum canis, who subsequently developed an abscess. complete resolution occurred after treatment with oral terbinafine. | 2000 | 11167972 |
| microsporum canis tinea capitis in an 8-month-old infant successfully treated with 2 weekly pulses of oral itraconazole. | we report an 8-month-old girl with tinea capitis caused by microsporum canis which was successfully treated with two pulses of oral itraconazole 50 mg/day, each of 1 week duration with an interval of 2 weeks. m. canis tinea capitis can be a difficult therapeutic problem in an infant, as the treatment is usually long, lasting up to 4-6 weeks with griseofulvin and 6-12 weeks with terbinafine, and the desire to provide a safe systemic therapy is particularly important. with an intermittent regimen ... | 2001 | 11207976 |
| antifungal activity of some mono, bis and quaternary mannich bases derived from acetophenone. | the development of resistance to current antifungal therapeutics drives search for new effective agents. some mannich bases have antifungal activity, but no information is available regarding the antifungal activity of acetophenone derived mannich bases. mono mannich bases of acetophenone 1-3 were synthesized and converted into their corresponding bis derivatives, 5-7. representative quaternary derivatives 4 and 8 were also synthesized. antifungal activities of the compounds were evaluated using ... | 2001 | 11215330 |
| tinea capitis in two elderly women: transmission at the hairdresser. | tinea capitis is rare in the elderly. we report cases of two elderly women who presented to our dermatology clinic within 8 weeks of each other, with scalp scaling and alopecia. in both cases, microsporum canis grew on fungal culture of their hair, and required prolonged treatment with terbinafine. neither of them gave a history of contact with young children or any animals. both were fairly fit and not systemically immunocompromised. however, both had been regularly visiting the same hairdresse ... | 2001 | 11298558 |
| dermatophytoses in children: study of 137 cases. | dermatophytoses are common fungal infections caused by dermatophytes but there are few data about this condition in the childhood. 137 children below the age of 12 and clinically diagnosed as tineas were investigated prospectively at instituto de puericultura e pediatria, rio de janeiro, from 1994 to 1999. hair, skin/nails scraping and pus swabs were collected from lesions and processed for fungus. male children from 2 to 12 years were mostly affected; tinea capitis (78 cases) mainly caused by m ... | 2001 | 11340481 |