Publications

antimicrobial bioassay of colchicum luteum baker.	the methanolic extract of the corms of colchicum luteum baker (liliaceae) and its subsequent fractions in different solvent systems were screened for antibacterial and antifungal activities. the crude extract and all the fractions demonstrated moderate to excellent antifungal activities against tested pathogens in antifungal bioassay. excellent antifungal activity was shown against trichophyton longifusus, up to 75%, and microsporum canis, up to 85%, while the crude extract and subsequent fracti ...	2006	17252951
in-vitro antibacterial, antifungal and cytotoxic properties of metal-based furanyl derived sulfonamides.	a new series of antibacterial and antifungal furanyl-derived sulfonamides and their cobalt (ii), copper (ii), nickel (ii) and zinc (ii) metal complexes have been synthesized, characterized and screened for their in-vitro antibacterial activity against four gram-negative (escherichia coli, shigella flexneri, pseudomonas aeruginosa and salmonella typhi) and two gram-positive (bacillus subtilis and staphylococcus aureus) bacterial strains and, for in-vitro antifungal activity against trichophyton l ...	2006	17252952
evaluation of fungicidal efficacy of benzalkonium chloride (steramina g u.v.) and virkon-s against microsporum canis for environmental disinfection.	the aim of this study is to evaluate the antifungal efficacy of steramina g u.v. (10% solution of alkyldimetylbenzylammonium chloride; formenti grünenthal) and virkon-s (multipurpose system; antec international) against microsporum canis-infected hairs and spores. samples were collected from a random sample of household cats and from subjects from catteries. seventy m. canis-positive hairbrushes containing furs, keratin scales and other organic material were treated with each of the two disinfec ...	2006	16437301
a twenty-year survey of dermatophytoses in braga, portugal.	modifications in social habits together with the increase of emigration have contributed not only to increased dermatophytoses but also to an altered etiology. during the last few years, braga has suffered a radical change from a rural to a cosmopolitan life-style.	2006	16863519
mycetes and urban areas.	mycetes are ubiquitous organisms that can cause mycoses in human and animals. the role of animals in the epidemiology of human mycoses in urban areas is multiform, but here will be discuss only two features: a) animals as vectors of mycoses and b) animal substrates as growth factor of pathogenic fungi. a) animals as vectors of mycoses: this role is important as zoofilic dermatophytes are very important agents of zoonosis; the urban dermatophytozoonoses are prevalent caused by microsporum canis w ...	2006	16881412
in vitro antifungal and anti-elastase activity of some aliphatic aldehydes from olea europaea l. fruit.	olea europaea preparations are traditionally employed in a variety of troubles, including skin infections. olive extracts and some of their pure compounds have shown antimicrobial activity in vitro. the present study deals with the antifungal activity of some aliphatic aldehydes from olive fruit [hexanal, nonanal, (e)-2-hexenal, (e)-2-heptenal, (e)-2-octenal, (e)-2-nonenal] against tricophyton mentagrophytes (6 strains), microsporum canis (1 strains) and candida spp. (7 strains). the capability ...	2006	16920510
tinea incognito in italy: a 15-year survey.	tinea incognito or steroid modified tinea is a dermatophytic infection in which topical or systemic steroids, administered as a result of dermatological misdiagnosis or preexisting pathologies, have modified the clinical appearance of the fungal infection, transforming the typical ringworm and mimicking other skin diseases. this is a retrospective study of the agents, clinical aspects, sources of infection of 200 cases (98 males, 102 females, mean age 42 years) of tinea incognito, observed in si ...	2006	16922789
isolation of microsporum canis from the hair coat of pet dogs and cats belonging to owners diagnosed with m. canis tinea corporis.	microsporum canis has been frequently isolated from human cases of tinea capitis and tinea corporis. the infection may be acquired from infected animals with cutaneous lesions but also from asymptomatic carriers or from the environment. as asymptomatic m. canis carriers are considered to be a critical factor in the epidemiology of dermatophytosis in humans, this study investigated the relationship between the presence of dermatophytes on the hair coats of dogs and cats without cutaneous lesions ...	2006	16961818
"carry-on" dermal baggage: a nodule from a dog. pyogranulomatous inflammation with intralesional fungal agents.	a 2-year-old intact female australian cattle dog presented with a 1-cm diameter nonexudative dermal nodule on the medial aspect of the right thigh. fine-needle aspiration revealed pyogranulomatous inflammation and many ovoid, 2-4 microm diameter, thin-capsulated, basophilic bodies that appeared to be fungal spores or yeast. results of cbc, serum chemistry panel, lymph node palpation, and radiographs were unremarkable. excisional biopsy and histopathology revealed pyogranulomatous folliculitis, f ...	2006	16967419
persistence of antibodies in blood and body fluids in decaying fox carcasses, as exemplified by antibodies against microsporum canis.	to assist in evaluating serological test results from dead animals, 10 silver foxes (vulpes vulpes) and 10 blue foxes (alopex lagopus), 6 of each species previously vaccinated against and all challenged with microsporum canis, were blood sampled and euthanased. fox carcasses were stored at +10 degrees c, and autopsy was performed on days 0, 2, 4, 7, and 11 post mortem during which samples from blood and/or body fluid from the thoracic cavity were collected. antibodies against m. canis were measu ...	2006	16987389
fontana-positive grains in mycetoma caused by microsporum canis.	we describe mycetoma caused by microsporum canis occurring in a 9-year-old african-american girl. pathologic evaluation showed a granulomatous dermatitis with numerous large fungal grains containing septate hyphae that were fontana-masson positive. two cultures of pure grains grew m. canis. mycetoma due to dermatophytes is very uncommon. the few instances reported have been pseudomycetoma (grains in the absence of sinus tracts). our patient developed sinus tracts (true mycetoma). no prior report ...	2006	17014645
study of the its region in an atypical isolate and comparison with six species of microsporum.	microsporum species are a frequent cause of cutaneous mycoses in humans. atypical strains of microsporum can sometimes be difficult to identify with conventional methods. recently, we have obtained a microsporum isolate with atypical morphology and special nutritional requirements (microsporum chus-126-02). as several molecular techniques have been developed for the identification of fungi, we analysed six microsporum species (m. canis, m. gypseum, m. gallinae, m. nanum, m. ferrugineum and m. pe ...	2006	17022760
prevalence of dermatophytosis in junior secondary schoolchildren in ogun state, nigeria.	a total of 2772 randomly selected junior secondary school pupils (aged 8-14) from 60 schools were examined for dermatophytic infections by direct microscopy and culture-based laboratory diagnostic methods. of these, 641 (23.21%) had dermatophytosis. out of these, 376 (13.56%) were male while 265 (9.56%) were female. aetiological agents identified with infection were microsporum canis (30.19%), microsporum audouinii (32.92%), trichophyton interdigitale (14.37%), trichophyton soudanense (9.73%) an ...	2006	17022768
canine dermatophytosis caused by an anthropophilic species: molecular and phenotypical characterization of trichophyton tonsurans.	microsporum canis is the most common species isolated from canine and feline dermatophytosis in the world. however, this study reports a rare case of canine dermatophytosis caused by the anthropophilic dermatophyte trichophyton tonsurans in the city of fortaleza, ceará, brazil. the fungal characterization was performed by classical mycological examination and by genotypical analysis using the restriction enzymes sau3a, rsai, ddei and ecori. the phenotypical characteristics were compatible with t ...	2006	17030920
[dermatophytoses transmitted from animals].	dermatophytoses are infectious skin diseases caused by some sorts of fungi - dermatophytes. based on their source dermatophytes are classified to geophilic, zoophilic and antrophophilic groups. animals are primary afflicted by zoophilic fungi, manifestations on their skin are highly infectious and fungi can be transmitted to humans. some members of zoophilic dermatophytes are: microsporum canis, trichophyton mentagrophytes var. mentagrophytes and trichophyton verrucosum. most common clinical fin ...	2006	17323620
incidence of tinea capitis in são paulo, brazil.	to determine the incidence of tinea capitis in são paulo, brazil, an investigation was performed in private and public pediatrics service involving 4,500 children from 0 to 15 years old during 5 years (1996-2000). samples were taken from 132 children with suspected fungal infection of the scalp, for direct microscopy and culture. tinea of scalp was mycologically confirmed in 112 patients (85%). males were more affected than females in all age groups. children below 8 years old accounted for more ...	2006	16897586
tinea capitis in a paediatric population.	tinea capitis is an increasing problem in europe. the pattern of infection is changing with an increase in pathogenic anthropophilic dermatophytes particularly trichophyton tonsurans. we aimed to determine the frequency of tinea capitis in a paediatric population attending dermatology outpatients and examine the clinical spectrum of disease. a retrospective analysis was performed of all laboratory proven tinea capitis cases presenting to the dermatology outpatient department at the children's un ...	2006	17274169
metal-based antibacterial and antifungal agents: synthesis, characterization, and in vitro biological evaluation of co(ii), cu(ii), ni(ii), and zn(ii) complexes with amino acid-derived compounds.	a series of antibacterial and antifungal amino acid-derived compounds and their cobalt(ii), copper(ii), nickel(ii), and zinc(ii) metal complexes have been synthesized and characterized by their elemental analyses, molar conductances, magnetic moments, and ir, and electronic spectral measurements. ligands (l(1))-(l(5)) were derived by condensation of beta-diketones with glycine, phenylalanine, valine, and histidine and act as bidentate towards metal ions (cobalt, copper, nickel, and zinc) via the ...	2006	17497020
activity of the triazole antifungal r126638 as assessed by corneofungimetry.	r126638 is a novel triazole exhibiting potent in vitro and in vivo antifungal activity against fungal pathogens including dermatophytes and yeasts.	2006	16247249
chemical composition and antidermatophytic properties of volatile fractions of hexanic extract from leaves of cupressus lusitanica mill. from cameroon.	the chemical composition of five column fractions of hexanic leaf extract of cupressus lusitanica were analysed by gas chromatography and gas chromatography-mass spectrometry and then tested for their antidermatophytic activities using the agar dilution method. the first fraction (f(1)) has only hydrocabon monoterpenes with alpha-pinene (80.0%) as major component. the main constituents of the second fraction (f(2)) were epi-bicyclosesquiphellandrene (35.3%), epi-zonarene (10.3%), 1s, cis-calamen ...	2006	16169171
aetiological agents of tinea capitis in tehran (iran).	a total of 1568 patients with suspected tinea capitis were examined for causative fungal agents between 1994 and 2001. laboratory examination confirmed tinea capitis in 209 patients. males were affected more frequently (67.5%) than females (32.5%) and in both sexes, those who were 3-11 years old, were more infected. trichophyton violaceum was the most common aetiological agent (37.3%) followed by trichophyton schoenleinii (21.5%), microsporum canis (18.6%), trichophyton verrocosum (14.8%), trich ...	2006	16367822
tinea capitis in eastern nepal.	tinea capitis is an increasing public health concern throughout the world. the clinical types and etiological agents vary from time to time and place to place. this study was undertaken to identify the etiological agents and to determine the clinico-etiological correlation of tinea capitis in eastern nepal.	2006	16445495
[statistical study of dermatomycosis - observations in sendai national hospital over a 30 year period].	a statistical 30-year study of dermatomycosis in sendai national hospital (1968-1997) revealed many changes in the prevalent diseases: tinea pedis and tinea unguium constantly increased during this period, and the ratio of the former associated with nail infection finally reached 30% of all tinea pedis patients. on the contrary, tinea corporis and cruris showed a remarkable decreasing tendency. patient age distribution of each disease also showed distinctive changes, generally increasing in the ...	2006	16465134
dermatophytoses in monterrey, méxico.	in the present report we reviewed a total of 2397 cases of dermatophytosis from superficial cutaneous lesions between the years 1978 and 1990. the cases included were from the department of dermatology at the university hospital located in the city of monterrey, méxico. a total of 726 tinea pedis, 613 tinea unguium, 441 tinea capitis, 395 tinea corporis and 222 tinea cruris cases were observed. the most commonly isolated dermatophyte species was trichophyton rubrum (45%), followed by trichophyto ...	2006	16466445
prevalence of zoonotic agents in dogs visiting hospitalized people in ontario: implications for infection control.	visitation of hospitalized people by dogs is becoming commonplace, but little is known about the potential health risks of introducing dogs to healthcare settings. this cross-sectional study evaluated the prevalence of zoonotic agents in a group of 102 visitation dogs from a variety of sources across ontario. between may and july 2004, owners were interviewed by a standardized questionnaire while dogs underwent a standardized physical examination. one specimen of faeces, hair-coat brushings and ...	2006	16466831
an evaluation of the clinical, cytological, infectious and histopathological features of feline acne.	clinical, cytological, microbial and histopathological features of feline acne were investigated in 22 cats referred or volunteered to a veterinary dermatology practice in the south-west region of the usa. for comparison, same parameters were evaluated in five unaffected pet cats. additionally, all cats were evaluated by immunohistochemistry (ihc) for the presence of feline calicivirus (fcv) and feline herpes virus (fhv-1) in acne lesions. the age of onset of acne in affected cats ranged from 6 ...	2006	16515656
kerion and dermatophytic granuloma. mycological and histopathological findings in 19 children with inflammatory tinea capitis of the scalp.	inflammatory tinea capitis or kerion is the result of a hypersensitivity reaction to a dermatophytic infection. majocchi's granuloma, in contrast, usually begins as a suppurative folliculitis and culminates in a granulomatous reaction.	2006	16533218
[tinea capitis in department of dermatology and venerology in the university hospital of donka at conakry, guinea].	the authors report the results of a study carried out on tinea capitis, in the department of dermatology and venerology at the university hospital of donka in conakry, during one year in this department, the tinea capitis represents 3.2% of the consultations and remains the second mycosis. out of 414 consulted children, a male predominance of 75% was noted especially regarding the trichophytic tinea. school children aged of 6-14 years old are the most affected by the disease. the trichophytic ti ...	2006	16568680
oxovanadium(iv) complexes of hydrazides: potential antifungal agents.	oxovanadium(iv) -derived antifungals have been prepared by condensing equimolar amounts of vanadyl sulfate with hydrazides. all the synthesized ligands and their metal complexes were characterized by ir, uv-visible and micro analytical data. these synthesized compounds were screened for their antifungal activity against aspergillus flavus (a. flavus), trichophyton longifusus (t. longifusus), candida albicans (c. albicans), microsporum canis (m. canis), fusarium solani (f. solani) and candida gla ...	2006	16570503
in vitro antibacterial, antifungal & cytotoxic activity of some isonicotinoylhydrazide schiff's bases and their cobalt (ii), copper (ii), nickel (ii) and zinc (ii) complexes.	isonicotinoylhydrazide schiff's bases formed by the reaction of substituted and unsubstituted furyl-2-carboxaldehyde and thiophene-2-carboxaldehyde with isoniazid and, their co (ii), cu (ii), ni (ii) and zn (ii) complexes have been synthesized, characterized and screened for their in vitro antibacterial activity against mycobacterium tuberculosis, escherichia coli, klebsiella pneumoniae, proteus mirabilis, pseudomonas aeruginosa, salmonella typhi, shigella dysenteriae, bacillus cereus, corynebac ...	2006	16570512
synthesis and evaluation of antimicrobial and anticonvulsant activities of some new 3-[2- (5-aryl-1,3,4-oxadiazol-2-yl/4-carbethoxymethylthiazol-2-yl) imino-4-thiazolidinon-5-ylidene]-5-substituted/nonsubstituted 1h-indole-2-ones and investigation of their structure-activity relationships.	in the present study, 20 new compounds having 3-[2-(5-aryl-1,3,4-oxadiazol-2-yl) imino-4-thiazolidinon-5-ylidene]-5-substituted/nonsubstituted 1h-indole-2-one (i-xii) and 3-[2-(4-carbethoxymethylthiazol-2-yl)imino-4-thiazoldinon-5-ylidenel-5-substituted/nonsubstituted ih-indole-2-one (xiii-xx) systems were synthesized. the structures were confirmed by spectral methods (uv, ir, 1h-nmr, 13c-nmr, 13c-dept (135), electron impact mass spectrometry) and elemental analysis. all compounds were tested fo ...	2006	16618017
[a new bioassay model of antibiotic susceptibility by corneofungimetry].	to study the value of a new bioassay model of antibiotic susceptibility by corneofungimetry which is more similar to human internal environment.	2006	16677528
isolation, characterization, and disruption of dnr1, the area/nit-2-like nitrogen regulatory gene of the zoophilic dermatophyte, microsporum canis.	a homolog of the major nitrogen regulatory genes area from aspergillus nidulans and nit-2 from neurospora crassa was isolated from the zoophilic dermatophyte, microsporum canis. this gene, dnr1, encodes a polypeptide of 761 amino acid residues containing a single zinc-finger dna-binding domain, which is almost identical in amino acid sequence to the zinc-finger domains of area and nit-2. the functional equivalence of dnr1 to area was demonstrated by complementation of an area loss-of-function mu ...	2006	16702104
unify qsar approach to antimicrobials. part 1: predicting antifungal activity against different species.	most of up-to-date reported molecular descriptors encode only information about the molecular structure. in previous papers, we have extended stochastic descriptors to encode additional information such as target site, partition system, or biological species [bioorg. med. chem. lett.2005, 15, 551; bioorg. med. chem. 2005, 13, 1119]. this work develops an unify markov model to describe with a single linear equation the biological activity of 74 drugs tested in the literature against some of the f ...	2006	16759868
epidemiology of tinea capitis in ceyhan district, adana in cukurova region, turkey.	this study was conducted on the primary school students in ceyhan district of adana, turkey between may and june 2002 to determine the clinical form, causative agents and prevalence of tinea capitis. a total of 9576 students, with a male-to-female ratio of 50.6-49.4% were screened in 24 primary schools. tinea capitis superficialis was diagnosed in seven cases, and kerion celsi in one. among eight cases, there were seven boys and one girl. trichophyton violaceum was the most frequent causative ag ...	2006	16784454
antimicrobial activity of indigofera suffruticosa.	various organic and aqueous extracts of leaves of indigofera suffruticosa mill (fabaceae) obtained by infusion and maceration were screened for their antibacterial and antifungal activities. the extracts were tested against 5 different species of human pathogenic bacteria and 17 fungal strains by the agar-solid diffusion method. most of the extracts were devoid of antifungal and antibacterial activities, except the aqueous extract of leaves of i. suffruticosa obtained by infusion, which showed s ...	2006	16786057
antibacterial, antifungal and cytotoxic properties of some sulfonamide-derived chromones.	a series of antibacterial and antifungal sulfonamide (sulfanilamide, sulfaguanidine, sulfamethaxozole, 4-aminoethylbenzene-sulfonamide and 4-amino-6-trifluoromethyl-benzene-1,3-disulfonamide) derived chromones, previously reported as inhibitors of carbonic anhydrase, have been screened for in-vitro antibacterial activity against four gram-negative (escherichia coli, pseudomonas aeruginosa, salmonella typhi and shigella flexener) and two gram-positive (bacillus subtilis and staphylococcus aureus) ...	2006	16789431
synthesis and biological evaluation of isomeric derivatives of naturally occurring spatozoate.	an isomer of the natural phthalate ester spatozoate (1), n-butyl 2-benzoyloxymethylbenzoate (2a) and a series of its new derivatives 2b-2s were synthesized and exposed to selected biological screening, as phthalates were reported to possess different biological activities. compound 2g was found to be the most potent cytotoxic agent with a ld50 = 8.98 microg/ml. in a bactericidal assay the compounds showed a broad spectrum of activities. compound 2a has a very promising fungicidal activity agains ...	2006	16821646
[new studies on the characterization of virulence factors in microsporum canis].	microsporum canis is a worldwide distributed zoophilic and zoonotic dermatophyte which is responsible for most cases of feline ringworm. its prevalence is on the rise in developed countries. since 1995, the author and his laboratory have developed a research programme to better understand the pathogenesis of m. canis dermatophytosis. both the potential fungal virulence factors and the host immune response were investigated. a 31.5 kda keratinolytic subtilase (sub) and a 43.5 kda keratinolytic me ...	2005	16465781
[dermatophytic disease in a tunisian family].	dermatophytic disease is a rare chronic infection caused by common dermatophytes and characterized by cutaneous and subcutaneous invasion. it is observed mainly in north africa where it is presumably inherited via an autosomal recessive trait. cellular immunodeficiency could account for the chronic nature of the disease and for its refractoriness to drug treatment. the purpose of this report is to describe the occurrence of dermatophytic disease in three sisters of consanguineous parents in a ru ...	2005	16465820
antifungal activity of fluid extract and essential oil from anise fruits (pimpinella anisum l., apiaceae).	antifungal activities of fluid extract and essential oil obtained from anise fruits pimpinella anisum l. (apiaceae) were tested in vitro on clinical isolates of seven species of yeasts and four species of dermatophytes. diffusion method with cylinders and the broth dilution method were used for antifungal activity testing. anise fluid extract showed antimycotic activity against candida albicans, c. parapsilosis, c. tropicalis, c. pseudotropicalis and c. krusei with mic values between 17 and 20% ...	2005	16375827
in-vitro antibacterial, antifungal and cytotoxic activities of some coumarins and their metal complexes.	a series of new antibacterial and antifungal coumarin-derived compounds and their transition metal complexes [cobalt (ii), copper (ii), nickel (ii) and zinc (ii)] have been synthesized, characterized and screened for their in vitro antibacterial activity against escherichia coli, klebsiella pneumoniae, proteus mirabilis, pseudomonas aeruginosa, salmonella typhi, shigella dysenteriae, bacillus cereus, corynebacterium diphtheriae, staphylococcus aureus and streptococcus pyogenes bacterial strains ...	2005	16206827
inhibition of the growth in vitro of trichophyton mentagrophytes, trichophyton erinacei and microsporum persicolor by miconazole and chlorhexidine.	an agar dilution technique was used to assess the minimum inhibitory concentrations (mics) of miconazole, chlorhexidine and a 1:1 combination of both agents for 9 isolates of trichophyton mentagrophytes, 9 isolates of trichophyton erinacei and 5 isolates of microsporum persicolor. mics of chlorhexidine did not vary significantly between the three dermatophyte species tested, but the mics of miconazole alone and in combination with chlorhexidine for t. erinacei were significantly greater that tho ...	2005	16238813
tinea faciei in a goat handler due to microsporum canis.		2005	16309360
reproducible genetic transformation system for two dermatophytes, microsporum canis and trichophyton mentagrophytes.	a reproducible genetic transformation system was developed for two major dermatophytes, microsporum canis and trichophyton mentagrophytes. two circular transformation vectors carrying either the bacterial hygromycin b phosphotransferase gene (hph) or both the hph and green fluorescent protein (egfp) genes under the control of a promoter sequence from cochlibolus heterostrophus were introduced independently into the protoplasts by a polyethylene glycol (peg)-mediated method. polymerase chain reac ...	2005	16320496
in vitro antifungal activity of dragon's blood from croton urucurana against dermatophytes.	based on ethnobotanical approach, the dragon's blood collected from croton urucurana baill. bark (euphorbiaceae) was tested for antifungal activity against five dermatophytes by paper disk diffusion method. the minimal inhibitory concentration (mic) showing no visible fungal growth was also determined, using tube dilution technique. the test dermatophytes were tricophyton tonsurans, trichophyton mentagrophytes, trichophyton rubrum, microsporum canis and epidermophyton floccossum. the dragon's bl ...	2005	15707783
comparison of disk diffusion method and broth microdilution method for antifungal susceptibility testing of dermatophytes.	the use of the agar diffusion neo-sensitabs method to determine antifungal susceptibility of 59 isolates of dermatophytes, namely epidermophyton floccosum, microsporum canis, m. gypseum, trichophyton mentagrophytes, t. rubrum and t. tonsurans to clotrimazole (clz), itraconazole (itz) and terbinafine (tbf) is described. results obtained are compared to the minimum inhibitory concentrations (mic) determined by an adaptation of the nccls-m38-a procedure. using the diffusion method, all strains show ...	2005	15712608
use of magnetic beads to extract fungal dna.	authors compare two methods of extracting dna from different fungi: the classic method with phenol/chloroform (p/c) and that with magnetic beads. both were tested on candida albicans and cryptococcus neoformans var. neoformans, belonging to the yeast group and microsporum canis, m. gypseum, trichophyton rubrum, t. interdigitale, t. ajelloi, epidermophyton floccosum, belonging to the dermatophytes group. extraction products underwent polymerase chain reaction (pcr) fingerprinting with the appropr ...	2005	15679657
tinea capitis in diyarbakir, turkey.	the incidence and types of tinea capitis in 234 children aged 1-12 referred to our laboratory with a preliminary diagnosis of tinea capitis infection in the past 5 years were investigated. tinea capitis was determined in 149 (63.7%) of these patients, of which agents grew in culture in 124 (83.2%). the most frequently isolated agents, in order of frequency, are as follows: trichophyton violaceum (43.6%), microsporum canis (37.9%), t. mentagrophytes (8.1%) and t. verrucosum (4.8%).	2005	15679658
epidemiology of dermatomycoses in children living in northern greece 1996-2000.	in the 5-years period, 1996-2000, 1045 children under 13 years old were examined for suspected dermatomycosis. in 611 cases fungi were isolated. male children were mainly affected on the scalp and body area. girls were more affected in the location of the arms and legs. there was a greater proportion of cases in the age range 2-12 years. the most prominent fungus was microsporum canis (515 cases) followed by trichophyton rubrum (34) and candida albicans (20). tinea capitis (280 cases) mainly cau ...	2005	15679659
characteristics of dermatophytoses among children in an area south of tehran, iran.	the aim of this study was to determine the prevalence and etiological agents of dermatophytoses, and also their distribution according to age, gender, and body site among children in an area south of tehran. a total of 382 children aged </=16 years suspected to have dermatophytic lesions were examined over a period of 3 years (1999-2001). the incidence rate of dermatophytoses was 6.6 per 100 000 person-years. trichophyton violaceum was the most frequent isolate (28.3%) followed by microsporum ca ...	2005	15679663
antifungal activity of ocimum gratissimum towards dermatophytes.	the development of more effective and less toxic antifungal agents is required for the treatment of dermatophytosis. plants and their preparations have been used as medicines against infectious diseases. extracts of ocimum gratissimum leaves were investigated for in vitro antifungal activity, using agar dilution technique against dermatophytes. the extracts (hexane, chloroform fractions, the essential oil and eugenol) produced antifungal activities against microsporum canis, m. gypseum, trichoph ...	2005	15842332
dermatophyte infections in the ljubljana region, slovenia, 1995-2002.	we studied dermatophyte infections in patients, examined in the mycological laboratory of the department of dermatology, university medical centre ljubljana during the period 1995-2002. a total of 42,494 samples were collected from 33,974 patients suspected to have dermatomycosis. dermatophytes were identified in 8286 (71.2%) positive cultures. microsporum canis was the most frequent dermatophyte isolated (46.8%), followed by trichophyton rubrum (36.7%), t. mentagrophytes var. interdigitale (7.9 ...	2005	15842334
development of an enzyme-linked immunosorbant assay (elisa) for the serodiagnosis of canine dermatophytosis caused by microsporum canis.	abstract in dogs, dermatophytosis should be considered in any case of alopecic, papular or pustular lesion. the aim of this study was to develop an enzyme-linked immunosorbant assay (elisa) as an aid in the diagnosis of canine dermatophytosis. the antigen used was a whole fungal extract obtained from an isolate of microsporum canis cultured on a liquid medium from the parasitized hair of a cat with patches of alopecia. to assess the elisa performances, sera from 18 dogs with dermatophytosis caus ...	2005	15842540
mycoses in thailand: current concerns.	scytalidium dimidiatum is the leading cause of fungal foot diseases in thailand, in contrast to similar studies in which dermatophytes have been identified as the predominant pathogens. by contrast, the prevalence of candida albicans in our study was only 2.6 approximately 3.0%. scytalidium fungal foot infection is clinically indistinguishable from that caused by dermatophytes and should be included as a possible cause of treatment failure in tinea pedis and onychomycosis. without proper culture ...	2005	15864252
once-weekly fluconazole in children with tinea capitis due to microsporum canis.		2005	15868642
repetitive-sequence-pcr-based dna fingerprinting using the diversilab system for identification of commonly encountered dermatophytes.	the performance of repetitive-sequence-based pcr (rep-pcr) using the diversilab system for identification of dermatophytes commonly isolated in a clinical laboratory was assessed by comparing results to those of conventional tests (colony morphology, microscopic examination of slide cultures, and, for suspected trichophyton species, use of additional media). sixty-one cultures were tested in phase 1, the feasibility portion of the study; 64 additional cultures were tested in phase 2, the validat ...	2005	15872233
antifungal activities of six south african terminalia species (combretaceae).	a serial microplate dilution method developed for bacteria was modified slightly and gave good results with several fungi. the antifungal activity of acetone, hexane, dichloromethane and methanol leaf extracts of six terminalia species (terminalia prunioides, terminalia brachystemma, terminalia sericea, terminalia gazensis, terminalia mollis and terminalia sambesiaca) were tested against five fungal animal pathogens (candida albicans, cryptococcus neoformans, aspergillus fumigatus, microsporum c ...	2005	15894142
organometallic-based antibacterial and antifungal compounds: transition metal complexes of 1,1'-diacetylferrocene-derived thiocarbohydrazone, carbohydrazone, thiosemicarbazone and semicarbazone.	organometallic-based, 1,1'-diacetylferrocene-derived antibacterial and antifungal thiocarbohydrazone, carbohydrazone, thiosemicarbazone and semicarbazone have been prepared by condensing equimolar amount of 1,1'-diacetylferrocene with thiocarbohydrazide, carbohydrazide thiosemicarbazide and semicarbazide, respectively. these were used as ligands for the preparation of their cobalt (ii), copper (ii), nickel (ii) and zinc (ii) metal complexes. all the synthesized ligands and their complexes were c ...	2005	15895689
therapeutic options for the treatment of tinea capitis: griseofulvin versus fluconazole.	tinea capitis is a relatively common fungal infection of childhood. griseofulvin has been the mainstay of treatment for many years. however, newer oral antifungal agents are being used more frequently.	2005	15897167
antidermatophyte activity of ether extract of nigella sativa and its active principle, thymoquinone.	the antifungal activity of ether extract of nigella sativa seed and its active principle thymoquinone was tested against eight species of dermatophytes: four species of trichophyton rubrum and one each of trichophyton interdigitale, trichophyton mentagrophytes, epidermophyton floccosum and microsporum canis. agar diffusion method with serial dilutions of ether extract of nigella sativa, thymoquinone and griseofulvin was employed. the incubation was carried out at 30 degrees c for 14 days. the di ...	2005	15908151
fluconazole upregulates sconc expression and inhibits sulphur metabolism in microsporum canis.	azole derivatives such as fluconazole are the mainstay of therapeutic agents for the treatment of fungal infections. their mode of action involving alteration in the conversion of lanosterol to ergosterol is well established. here we report the effect of fluconazole on the sulphur metabolism negative regulator gene (sconc) in microsporum canis. characterization of the m. canis sconc gene revealed that its orf is comprised of 495bp interrupted by four introns of 47-70bp. exposure of m. canis in s ...	2005	15922636
[incidence, immunity and treatment of feline dermatophytosis].	feline dermatophytosis is a superficial skin infection characterized by the invasion of cornified tissues such as hair and nails. this infection is nearly always caused by microsporum canis. infected animals release infective spores in the environment which will then contaminate other animals or humans. infected animals usually develop immunity so the infection will spontaneously disappear after a few weeks to months. long haired and immunocom-promised cats do not have the same ability to acquir ...	2005	15929601
[evaluation the antimycotic activity of itraconazole in human stratum corneum with vitro fungi cultivation].	to establish a new model to evaluate the antifungal activity of antimycotics.	2005	15949332
in-vitro antibacterial, antifungal and cytotoxic properties of sulfonamide--derived schiff's bases and their metal complexes.	a series of new antibacterial and antifungal schiff's bases derived from sulfonamides, as well as their transition metal complexes incorporating cobalt (ii), copper (ii), nickel (ii) and zinc (ii) were synthesized, characterized and screened for their in-vitro antibacterial activity against six gram-negative (escherichia coli, klebsiella pneumoniae, proteus mirabilis, pseudomonas aeruginosa, salmonella typhi and shigella dysentriae) and four gram-positive (bacillus cereus, corynebacterium diphth ...	2005	15968823
inter-single-sequence-repeat-pcr typing as a new tool for identification of microsporum canis strains.	microsporum canis is a ubiquitous dermatophyte that commonly causes human infections. since contact with infected animals is the usual way of infection, tracing its source is an essential preventive measure.	2005	15978415
evaluation of antimicrobial activities of several mannich bases and their derivatives.	the aim of this study was to evaluate the antimicrobial activities of several mannich bases and their derivatives against pathogenic bacteria and fungi. 3-dimethylamino-1-phenyl-1-propanone hydrochloride (ig1) as mono-mannich base, bis(beta-aroylethyl)methylamine hydrochlorides (b1, b5) as bis-mannich bases, 3-aroyl-4-aryl-1-methyl-4-piperidinol hydrochlorides (c1, c5) as piperidinol derivatives, which are structural isomers of bis-mannich bases, n,n'-bis(3-dimethylamino-1-phenylpropylidene)hydr ...	2005	15981301
antifungal susceptibilities of dermatophytic agents isolated from clinical specimens.	the aim of this study was to investigate the susceptibility to four antifungal agents: ketoconazole, terbinafine, itraconazole and fluconazole, of the different species of dermatophyte strains isolated from clinical specimens. a total of 128 specimens were collected from toe nail, foot, inguinal region, trunk, hands and head. the dermatophytes tested included trichophyton rubrum 108 (84.4%), trichophyton mentagrophytes 11 (8.6%), epidermophyton floccosum 5 (3.9%), microsporum canis 2 (1.5%) and ...	2005	16048753
dermatophytes growth curve and in vitro susceptibility test: a broth micro-titration method.	the introduction of systemic antifungal drugs which act upon different targets is the main issue of the in vivo antifungal resistance control. different factors, such as growth curve phase, quality of the specimen, quantity of the inoculum, temperature, ph, culture medium composition, incubation duration and solvent, are believed important factors affecting minimum inhibitory concentration (mic) value to most of the antifungal agents. we assayed an in vitro susceptibility test with 40 isolates o ...	2005	16110777
seasonal 4-year investigation into the role of the alpine marmot (marmota marmota) as a carrier of zoophilic dermatophytes.	two hundred and six samples of alpine marmot (mamota marmota) hair (148 from adults and 58 from young subjects), 102 soil samples from the entrances to the burrows of the above individuals and 20 control specimens (obtained from adjoining areas away from the burrow systems where the rodents are not usually present) were examined from may 1994 to september 1997. seventy-five isolates belonging to six species of dermatophytes were found in 69 of the 206 hair samples examined (33.5%). two species w ...	2005	16110784
eighty-four consecutive cases of tinea faciei in siena, a retrospective study (1989-2003).	consecutive cases of tinea faciei diagnosed in siena between 1989 and 2003 were studied retrospectively for differences in clinical form, demographic data and species of dermatophyte isolated. the series consisted of 84 cases (59 females, 25 males) with a mean age of 27 years. mean age of females (32.4 years) was significantly greater than that of males (14.2 years). the dermatophytes most frequently isolated were microsporum canis (38 cases) and trichophyton rubrum (31 cases). clinical form was ...	2005	16115106
metalloprotease gene of arthroderma gypseum.	the full-length cdna sequence for metalloprotease (mep) of arthroderma gypseum (one of the teleomorphs of the microsporum gypseum complex) was determined by the 5'-rapid amplification of cdna ends (race) and 3'-race methods using cdna as a template. the full-length cdna sequence of the mep (2,670 bp) gene was proved to encode 677 amino acids. the amino acid sequence of the a. gypseum mep gene shared about 89 and 66% sequence similarity with the conserved region of the microsporum canis mep gene ...	2005	16116253
antifungal susceptibility and genotypical pattern of microsporum canis strains.	dermatophytes are a group of fungi that are capable of invading keratinized tissues of humans and other animals. antifungal susceptibility analysis and genetic studies by random amplification of polymorphic dna (rapd), have been used to detect polymorphism as well as determining the possible resistance of dermatophytes to antifungals. the aim of this study was to evaluate the possible correlation between the antifungal susceptibility and genotypical pattern of microsporum canis strains isolated ...	2005	16121230
[enzyme activities of dermatophytes isolated from different clinical samples by apizym method].	dermatophytes' enzymes may have a role in chronic superficial infections. in this study it was planned to investigate the possible relationship between the enzymatic activities of the dermatophytes and acute or chronic course of the infections. dermatophytes were isolated from 58 (72%) out of 81 patients with superficial infections. the infections were divided into two groups as acute (< or = 6 weeks) or chronic (> 6 weeks). isolated fungi were identified by the classical methods and apizym meth ...	2005	16128029
lung cancer in asian women-the environment and genes.	the mortality rate of lung cancer in asian women has increased significantly in the past few decades. environmental factors include tobacco smoke (active and environmental), other indoor pollutions (cooking oil vapours, coal burning, fungus spores), diet, and infections. active tobacco smoking is not the major factor. the relative risk of lung cancer among non-smoking women ever exposed to environmental smoke from their husbands was 1.20 from a meta-analysis. cooking oil vapours associated with ...	2005	16135162
phenotypical and molecular characterization of microsporum canis strains in north-east brazil.	this study investigated the possible correlation between the phenotypical and genotypical characteristics of microsporum canis isolated from cats and dogs in north-east brazil.	2005	16162228
survey of dermatophytes on clinically normal cats in the southeast of england.	to report the incidence of dermatophytes on the hair coat of asymptomatic cats in the southeast of england. asymptomatic cats are often blamed for transmission of dermatophytes between animals and humans. this study may help to clarify whether cats are responsible for the increase in fungal infections among the human population.	2005	16167594
is itraconazole the treatment of choice in microsporum canis tinea capitis?	mycotic scalp infection caused by microsporum canis is the most dominant cause of tinea capitis in greece. griseofulvin has been the gold standard for the treatment of tinea capitis, but it is unavailable in our country. in this study, we evaluated 111 children with m. canis tinea capitis that were treated with itraconazole. eighty-one of them were treated with itraconazole capsule pulse therapy (group a) and 30 (group b) were treated with oral suspension administered in continuous regimen. twen ...	2005	16444907
importance of mycological confirmation of clinically suspected cases of tinea corporis, tinea pedis and tinea cruris.	tinea corporis, tinea cruris, and tinea pedis are of the most prevalent dermatophytoses. several conditions that mimic dermatophytoses and atypical and steroid modified forms of the disease usually present difficulties in diagnosis. hence, the present investigation aimed at studying these conditions on mycological basis. the study included 163 cases clinically diagnosed as having tinea corporis, tinea pedis or tinea cruris. specimens were taken by skin scraping. samples were cultured on sabourau ...	2004	16916049
evaluation of microsporum canis in different methods of storage.	the main objective of this investigation was to evaluate different methods of storage for microsporum canis based on materials and equipment that are readily available in developing countries. we tested 32 strains of m. canis at - 20 degrees c in potato dextrose agar (pda) in its plain condition, or amended with 10% dimethyl sulfoxide or with 10% glycerol. in addition, we tested 25 degrees c storage of isolates in plain saline (0.9% nacl) and in saline covered with a mineral-oil layer. after 9 m ...	2004	15682637
[dermatophyte species isolated from patients prediagnosed as onychomycosis and the value of fungal culture].	in this study, the clinical specimens taken from 390 patients who were prediagnosed as onychomycosis have been investigated by direct microscopy and culture methods, in the mycology unit of central laboratory of kocaeli university medical faculty. twenty-one (41.2%) of the 51 microscopically positive samples revealed positive cultures for dermatophytes, whereas 32 (9.4%) samples were culture positive among the 399 samples which were microscopically negative. the most frequently isolated dermatop ...	2004	15700670
[investigation of the inter-observer agreement rates for morphometric evaluation of the growth of microsporum canis colonies].	morphometry is a newly applied method for investigation of the in-vitro growth dynamics of dermatophyte colonies. this study was undertaken to evaluate the correlation and agreement rates between the morphometric data obtained by different observers. for this purpose, five different microsporum canis growth data were evaluated by six observers. the results of the study suggested that the agreement rates among the data obtained by different observers were low (r1 = -5.3509), while the results obt ...	2004	15700671
[superficial infections caused by microsporum canis in humans and animals].	dermatophytic infections caused by m. canis in humans and animals have a world wide distribution and they are zoonotic. the objective in this work was to know the frequency of m. canis infections in humans and pets. we studied our cases from january 1994 to december 2002. the human samples were obtained from a dermatological department in a general hospital and we registered the next data: age, sex, job, and affected area. the animal samples were obtained from a mycological veterinary laboratory ...	2004	15458362
tinea capitis caused by microsporum canis treated with terbinafine.	tinea capitis is a disease found throughout the world. it frequently affects children and only rarely adults, usually post-menopausal women. numerous dermatophytes of the genus microsporum and tricophyton can cause tinea capitis and griseofulvin is still today the treatment of choice. to study the effectiveness and tolerability of terbinafine treatment in tinea capitis caused by microsporum canis we treated 26 patients - 22 children and four women - for a period of 12 weeks. dosage adopted was 6 ...	2004	15504128
bizarre annular lesion emerging as tinea incognito.	tinea incognito has first been described in 1968. the term describes a tinea infection whose clinical morphology has been modified by the application of topical corticosteroids. the clinical manifestation can masquerade a number of other dermatoses and leads to misdiagnosis of annular eruptions. we describe a patient who showed a bizarre appearance of annular, inflammatory skin lesions at the umbilical region. mycological culture yielded microsporum canis.	2004	15504132
efficacy of pre-treatment with lufenuron for the prevention of microsporum canis infection in a feline direct topical challenge model.	oral lufenuron is reportedly an effective treatment for some cats with dermatophytosis. the purpose of this study was to determine if lufenuron, when used as a pre-treatment prior to challenge exposure, would be protective against the development of infection after the direct topical application of fungal macrocondia (microsporum canis spores). three groups (n = 6/group) of juvenile cats were treated with either monthly oral lufenuron (30 or 133 mg/kg) or placebo. after 2 months of treatment, ki ...	2004	15585010
in vitro evaluation of griseofulvin against clinical isolates of dermatophytes from isfahan.	fifty dermatophyte isolates, recently obtained from clinical materials, belonging to trichophyton mentagrophytes, t. verrucosum, microsporum canis and epidermophyton floccosum were examined for their susceptibility to griseofulvin. the minimum inhibitory concentration (mic) values were obtained using the modified microdilution method. all 100% tested isolates had mic geometric mean at a concentration between 0.43 and 0.95 microg ml(-1) the mic(90)s and mic(50)s were 8 microg ml(-1) and <0.25-1 m ...	2004	15601457
the epidemiology of canine and feline dermatophytoses in southern italy.	a total of 424 animals (268 dogs and 156 cats) with skin lesions (alopecia and peripheral scaling) were examined from january 1999 to december 2002. of the 424 samples examined, 99 (23.3%) yielded a positive culture and, in particular, 20.5% of the dog samples and 28.2% of the cat samples. microsporum canis was the most common dermatophyte isolated from dogs and cats (77.7%), followed by geophilic dermatophyte species (m. gypseum, trichophyton terrestre). young dogs and cats, especially those yo ...	2004	15601458
isatin-derived antibacterial and antifungal compounds and their transition metal complexes.	a series of isatins incorporating thiazole, thiadiazole, benzothiazole and p-toluene sulfonyl hydrazide moieties, along with their cobalt(ii), copper(ii), nickel(ii) and zinc(ii) metal complexes have been synthesized and characterized by elemental analyses, molar conductances, magnetic moments, ir, nmr and electronic spectral data. these compounds have been screened for antibacterial activity against escherichia coli, bacillus subtillis, shigella flexneri, staphylococcus aureus, pseudomonas aeru ...	2004	15648656
molecular typing study of the microsporum canis strains isolated from an outbreak of tinea capitis in a school.	tinea capitis is a dermatophyte infection of the scalp that occurs most often in prepubescent children. tinea capitis may be transmitted by shared use of contaminated hairbrush, by contact with fomites or by direct physical contact with an infected person. occasionally, outbreak of tinea capitis would happen under some special conditions. last year, we found an outbreak of tinea capitis in a school due to microsporum canis. in epidemiological study, we performed the prevalence survey to all of t ...	2004	15008343
efficacy and tolerability of 8 weeks' treatment with terbinafine in children with tinea capitis caused by microsporum canis: a comparison of three doses.	tinea capitis caused by microsporum canis is the most common mycosis of the scalp in preschool and school-aged children in greece.	2004	15009293
new treatments for tinea capitis.	tinea capitis, a dermatophyte infection involving the hair shaft on the scalp, is primarily a disease of preadolescent children. the predominant pathogen varies according to the geographical location. trichophyton tonsurans and microsporum canis account for the majority of infections in north america and certain parts of europe. the current standard of care for the treatment of tinea capitis in the usa is oral griseofulvin, but evidence is accumulating that some of the newer antifungal agents ma ...	2004	15021047
antibacterial and antifugal mono- and di-substituted symmetrical and unsymmetrical triazine-derived schiff-bases and their transition metal complexes.	a new series of antibacterial and antifungal triazine-derived mono- and di-substituted (symmetrical and unsymmetrical) schiff-bases and their cobalt(ii), copper(ii), nickel(ii) and zinc(ii) metal complexes have been synthesized and characterized by their elemental analyses, molar conductances, magnetic moments and ir and electronic spectral measurements. ir spectra indicated the ligands to act as tridentate towards divalent metal ions via a trazine-n, the azomethine-n and, indole-nh and deproton ...	2004	15449731
population structure and evolutionary origins of microsporum canis, m. ferrugineum and m. audouinii.	the recurrent evolutionary emergence of asexual lineages within sexual zoo- and anthropophilic dermatophyte species living in animal-frequented soil is likely to be triggered by changes in ecological niche, i.e., shifts of host animal. subsequent adaptation to the new host species is noted. sometimes geographic isolation or intrinsic host factors like human race may also play a role in speciation. in the present study, we elaborate concepts of speciation in dermatophytes using the microsporum ca ...	2004	15450196
lung cancer epidemiology and risk factors in asia and africa.	in industrialised countries, lung cancer is the most common form of cancer among males and it is growing among females. for both sexes, rates reflect smoking behaviours. the pattern appears to be different in asia, particularly in china, where lung cancer rates in men reflect high smoking rates but high rates among non-smoking women appear to be related to other factors. the incidence of lung cancer is low in most african countries, but it is increasing. in addition to tobacco smoking, a number ...	2004	15455588
treatment of microsporum spp. tinea capitis with pulsed oral terbinafine.	oral terbinafine is widely used in the treatment of superficial dermatomycoses as well as subcutaneous and systemic mycoses. it is also useful in treating tinea capitis, although for microsporum canis and some ectothrix organisms, the effectiveness of the drug may be less than for some endothrix infections. in this study, we undertook a double-blind randomized trial comparing standard and double doses of terbinafine given in a pulsed protocol (1 week on, 3 weeks off) in treating microsporum spp. ...	2004	15115516
derivatives of phosphate schiff base transition metal complexes: synthesis, studies and biological activity.	we report the synthesis and structural characterization of series of tetra- and hexacoordinate metal chelate complexes of phosphate schiff base ligands having the general composition lmx(n).h(2)o and l(2)mx(n) (l=phosphate schiff base ligand; m=ag(+), mn(2+), cu(2+), zn(2+), cd(2+), hg(2+), or fe(3+) and x=no(3)(-), br(-) or cl(-)). the structure of the prepared compounds was investigated using elemental analysis, ir, 1h and 31p nmr, uv-vis, mass spectra, solid reflectance, magnetic susceptibili ...	2004	14670488
evaluation of immunogenicity and protective efficacy of a microsporum canis metalloprotease subunit vaccine in guinea pigs.	in order to identify protective immunogens against microsporum canis infection, a purified recombinant keratinolytic metalloprotease (r-mep3) was tested as a subunit vaccine in experimentally infected guinea pigs. both humoral and cellular specific immune responses developing towards r-mep3 were evaluated, by enzyme-linked immunosorbent assay and by in vitro lymphocyte transformation tests respectively. vaccination induced a strong antibody response, and a significant but transient lymphoprolife ...	2004	14734190
pcr and pcr-rflp techniques targeting the dna topoisomerase ii gene for rapid clinical diagnosis of the etiologic agent of dermatophytosis.	we have focused on the dna topoisomerase ii genes of several pathogenic fungi, and developed polymerase chain reaction (pcr) and pcr-restriction fragment length polymorphism (rflp) methods targeting this gene for identification of dermatophytes.	2004	14757280
antimicrobial activity of hyptis ovalifolia towards dermatophytes.	the essential oil and the aqueous, hexane and methanolic fractions from hyptis ovalifolia leaves were evaluated for their antifungal activity in vitro against 60 strains of dermatophytes: 10 strains of microsporum canis, 10 of m. gypseum, 20 of trichophyton rubrum and 20 of t. mentagrophytes. the extracts inhibited growth of the dermatophytes tested at different concentrations. the most biologically active was the essential oil from the leaves which inhibited 57 isolates (95%) at a concentration ...	2004	14762526